What are the primary uses of Allegra Allergy. How should Allegra Allergy be taken for optimal effectiveness. What are the potential side effects of Allegra Allergy. How does Allegra Allergy interact with other medications. What precautions should be taken when using Allegra Allergy.

Understanding Allegra Allergy: A Powerful Antihistamine

Allegra Allergy, also known by its generic name fexofenadine, is a widely used antihistamine medication designed to provide relief from various allergy symptoms. As an over-the-counter (OTC) drug, it has become a popular choice for those seeking respite from the discomfort of allergic reactions.

How does Allegra Allergy work? The medication functions by blocking histamine, a natural substance produced by the body during an allergic reaction. By inhibiting histamine’s effects, Allegra Allergy helps alleviate a range of symptoms associated with allergies.

Common Symptoms Treated by Allegra Allergy

• Watery eyes
• Runny nose
• Itching eyes and nose
• Sneezing
• Hives
• General itching

Proper Usage and Dosage Guidelines for Allegra Allergy

To ensure the safe and effective use of Allegra Allergy, it’s crucial to follow the recommended dosage instructions. For over-the-counter products, always read the packaging directions carefully before use. If prescribed by a doctor, adhere to their specific instructions.

How often should Allegra Allergy be taken? Typically, the medication is taken twice daily, with approximately 12 hours between doses. However, dosage may vary based on factors such as age, medical condition, and individual response to treatment.

Different Forms of Allegra Allergy

1. Tablets/Capsules: Can be taken with or without food
2. Liquid Form: Shake well before use and measure with a special device
3. Rapidly-Dissolving Tablets: Take on an empty stomach, allowing it to dissolve on the tongue

Is it safe to take Allegra Allergy with fruit juices? It’s important to avoid taking Allegra Allergy with fruit juices such as apple, grapefruit, or orange, as these can decrease the absorption of the medication. Water is the recommended liquid for taking this medication.

Potential Side Effects and Precautions

While Allegra Allergy is generally well-tolerated, some individuals may experience side effects. It’s essential to be aware of these potential reactions and know when to seek medical attention.

Common Side Effects

• Cough
• Fever
• Stomach upset

Are there any serious side effects associated with Allegra Allergy? While rare, serious allergic reactions can occur. Symptoms of a severe allergic reaction may include rash, itching/swelling (especially of the face, tongue, or throat), severe dizziness, and difficulty breathing. If any of these symptoms occur, seek immediate medical attention.

Drug Interactions and Precautions

Understanding potential drug interactions is crucial for the safe use of Allegra Allergy. Certain medications and substances can affect how Allegra Allergy works in the body or increase the risk of side effects.

Key Precautions

• Avoid taking antacids containing aluminum and magnesium within 2 hours of Allegra Allergy
• Inform your doctor of all medications and supplements you’re taking
• Use caution if you have kidney disease
• Consult a healthcare provider before use if pregnant or breastfeeding

Can Allegra Allergy interfere with lab tests? Yes, this medication may interfere with certain lab tests, particularly allergy skin testing. It’s important to inform all healthcare providers and lab personnel about your use of Allegra Allergy to prevent false test results.

Special Considerations for Different Formulations

Allegra Allergy comes in various formulations, each with its own set of considerations. Understanding these can help users choose the most appropriate form for their needs and lifestyle.

Liquid Formulation

Does the liquid form of Allegra Allergy contain sugar? Some liquid formulations may contain sugar, which is an important consideration for individuals with diabetes or those following a sugar-restricted diet. Always check the ingredient list or consult with a pharmacist if you have concerns about sugar content.

Rapidly-Dissolving Tablets

What should individuals with phenylketonuria (PKU) know about rapidly-dissolving Allegra Allergy tablets? These tablets may contain aspartame, an artificial sweetener that people with PKU need to avoid or limit in their diet. If you have PKU, it’s crucial to consult with your healthcare provider before using this form of Allegra Allergy.

Pregnancy and Breastfeeding Considerations

The use of Allegra Allergy during pregnancy and breastfeeding requires careful consideration and consultation with a healthcare provider.

Is Allegra Allergy safe to use during pregnancy? While Allegra Allergy should only be used during pregnancy when clearly necessary, it’s essential to discuss the potential risks and benefits with your doctor. They can provide personalized advice based on your specific situation and health status.

Can Allegra Allergy be used while breastfeeding? Allegra Allergy does pass into breast milk. If you’re breastfeeding, it’s crucial to consult with your doctor before using this medication to ensure the safety of your infant.

Managing Overdose Situations

While following recommended dosages greatly reduces the risk, it’s important to be aware of potential overdose situations and know how to respond.

What should you do if you suspect an overdose of Allegra Allergy? If an overdose is suspected, it’s crucial to seek emergency medical attention immediately. Contact your local poison control center or emergency room for guidance. In the US, you can reach the poison control center at 1-800-222-1222.

Symptoms of Overdose

• Dizziness
• Drowsiness
• Dry mouth
• In severe cases, rapid heartbeat or fainting

How can overdose situations be prevented? Always adhere to the recommended dosage, keep medications out of reach of children, and never share your prescription with others. If you have any doubts about dosing, consult with a healthcare professional.

Long-Term Use and Effectiveness

For individuals with chronic allergies, understanding the long-term use and effectiveness of Allegra Allergy is crucial for managing their condition effectively.

Can Allegra Allergy be used for extended periods? While Allegra Allergy is generally considered safe for long-term use, it’s important to consult with a healthcare provider for personalized advice. They can monitor your condition and adjust treatment as necessary.

Factors Affecting Long-Term Effectiveness

• Individual response to the medication
• Changes in allergy triggers over time
• Development of tolerance
• Adherence to proper usage guidelines

How can you maximize the effectiveness of Allegra Allergy over time? Combining medication use with environmental control measures, such as reducing exposure to allergens, can enhance the overall effectiveness of your allergy management strategy. Regular follow-ups with your healthcare provider can also help ensure that your treatment remains optimal.

Alternatives and Complementary Treatments

While Allegra Allergy is effective for many individuals, it’s not the only option available for allergy relief. Understanding alternatives and complementary treatments can provide a more comprehensive approach to managing allergies.

Other Antihistamines

• Cetirizine (Zyrtec)
• Loratadine (Claritin)
• Desloratadine (Clarinex)

How do these alternatives compare to Allegra Allergy? Each antihistamine has a slightly different chemical structure and may affect individuals differently. Some people may find one more effective or tolerable than others. It’s often a matter of personal response and preference.

Non-Medicinal Approaches

1. Nasal irrigation
2. Air purifiers
3. Allergen-proof bedding
4. Dietary changes

Can natural remedies be used alongside Allegra Allergy? Many natural remedies, such as saline nasal rinses or certain herbal supplements, can be used in conjunction with Allegra Allergy. However, it’s crucial to consult with a healthcare provider before combining treatments to ensure safety and effectiveness.

Navigating Seasonal Allergies with Allegra Allergy

Seasonal allergies can be particularly challenging, with symptoms intensifying during specific times of the year. Allegra Allergy can play a crucial role in managing these seasonal flare-ups effectively.

When should you start taking Allegra Allergy for seasonal allergies? For optimal effectiveness, it’s often recommended to start taking Allegra Allergy before the allergy season begins. This proactive approach can help prevent symptoms from developing or becoming severe.

Tips for Maximizing Allegra Allergy’s Effectiveness During Allergy Seasons

• Monitor pollen counts and plan outdoor activities accordingly
• Keep windows closed during high pollen days
• Shower and change clothes after spending time outdoors
• Use air purifiers in your home
• Consider wearing a mask when doing outdoor chores

How can you combine Allegra Allergy with other allergy management strategies? While Allegra Allergy addresses the symptoms, it’s equally important to reduce exposure to allergens. Implementing strategies like using HEPA filters, regularly cleaning your living space, and avoiding known triggers can enhance the overall effectiveness of your allergy management plan.

Pediatric Use of Allegra Allergy

Allegra Allergy is approved for use in children, but there are specific considerations and dosage adjustments to keep in mind when administering this medication to younger patients.

At what age can children start using Allegra Allergy? The appropriate age for starting Allegra Allergy can vary depending on the specific formulation. Generally, it’s approved for children as young as 2 years old, but always consult with a pediatrician for personalized advice.

Age-Specific Dosing Guidelines

• Ages 2-11: Typically a lower dose, often given twice daily
• Ages 12 and up: Usually the same dosage as adults

Are there any special precautions for children taking Allegra Allergy? Children may be more sensitive to certain side effects, such as drowsiness. It’s important to monitor their response to the medication closely and report any unusual symptoms to their healthcare provider.

Allegra Allergy and Lifestyle Considerations

Understanding how Allegra Allergy interacts with various lifestyle factors can help users optimize their treatment and maintain their quality of life.

Does Allegra Allergy cause drowsiness? Unlike some older antihistamines, Allegra Allergy is considered a non-drowsy option. However, individual responses can vary, and some people may experience mild drowsiness, especially when first starting the medication.

Considerations for Daily Activities

• Driving and operating machinery: Generally safe, but be aware of your individual response
• Alcohol consumption: May increase the risk of side effects
• Exercise: No specific restrictions, but stay hydrated
• Travel: Suitable for use while traveling, but consider time zone changes for dosing

How can you adjust your Allegra Allergy use for shift work or irregular sleep schedules? Maintaining a consistent 12-hour interval between doses is ideal. If your schedule is irregular, consult with your healthcare provider for a personalized dosing strategy that aligns with your lifestyle.

Future Developments and Research in Allergy Treatment

The field of allergy treatment is continuously evolving, with ongoing research into new medications and treatment approaches. While Allegra Allergy remains a staple in allergy management, it’s worth keeping an eye on emerging developments.

What new allergy treatments are on the horizon? Researchers are exploring various avenues, including targeted immunotherapies, novel drug delivery methods, and combination therapies that could provide more comprehensive allergy relief.

Areas of Active Research

• Long-acting antihistamines with fewer side effects
• Personalized medicine approaches for allergy treatment
• Biologic therapies for severe allergic conditions
• Improved understanding of the immune system’s role in allergies

How might future developments impact the use of medications like Allegra Allergy? While traditional antihistamines like Allegra Allergy are likely to remain important, future treatments may offer more targeted approaches or longer-lasting relief. Staying informed about these developments can help individuals make the best choices for their allergy management in consultation with their healthcare providers.

Allegra Allergy Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Fexofenadine is an antihistamine used to relieve allergy symptoms such as watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.

How to use Allegra Allergy Tablet Antihistamines

If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed, usually 2 times daily (every 12 hours).

If you are using the liquid form of this medication, shake the bottle well before each dose and measure the dose carefully using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. Take the tablet/capsule or liquid form of this medication with or without food. If you are using the rapidly-dissolving tablet, take it on an empty stomach. Allow the rapidly-dissolving tablet to dissolve on the tongue and then swallow, with or without water. Do not remove the tablet from the blister pack until right before using.

If you need a liquid to take this medication (such as when taking the tablets/capsules), then take this medication with water. Do not take with fruit juices (such as apple, grapefruit, or orange) since they may decrease the absorption of this drug.

The dosage is based on your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed.

Do not take antacids containing aluminum and magnesium within 2 hours of taking this medication. These antacids can decrease the absorption of fexofenadine.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Cough, fever, or stomach upset may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US –

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking fexofenadine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Liquid products may contain sugar. The rapidly-dissolving tablets may contain aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet. Ask your doctor or pharmacist about using this product safely.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

This medication may interfere with certain lab tests (such as allergy skin testing), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Allegra Allergy Tablet Antihistamines interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Keep all medical and lab appointments.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Different brands of this medication may have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Allegra Allergy 60 mg tablet

Color: peachShape: oblongImprint: e 06

This medicine is a peach, oblong, film-coated, tablet imprinted with “e” and “06”.

Allegra Allergy 60 mg tablet

Color: peachShape: oblongImprint: e 06

This medicine is a peach, oblong, film-coated, tablet imprinted with “e” and “06”.

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Have you ever purchased Allegra Allergy Tablet Antihistamines?

Yes, In the past 3 months

Yes, In the past 6 months

Yes, In the past year

Haven’t purchased but considering

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This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Allegra-D 12 Hour Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This combination medication is used to temporarily relieve symptoms caused by the common cold, flu, or allergies. It contains 2 medications: fexofenadine and pseudoephedrine. Fexofenadine is an antihistamine that helps relieve watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Pseudoephedrine is a decongestant that helps relieve stuffy nose and ear congestion symptoms.This medication is not recommended for use in children under 12 years of age due to the large amount of pseudoephedrine in it.

How to use Allegra-D 12 Hour

If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication. If you have any questions, consult your pharmacist. If your doctor has prescribed this medication, take it as directed.

Take this medication by mouth on an empty stomach (at least 1 hour before or 2 hours after a meal). Take this medication with water. Do not take with fruit juices (such as apple, grapefruit, or orange) since they may decrease the absorption of this drug.

Swallow the tablets whole. Do not crush or chew the tablets. Doing so can release all of the drug at once, increasing the risk of side effects.

The dosage is based on your medical condition and response to treatment. Do not increase your dose or take this medication more often than directed.

Do not take antacids containing aluminum and magnesium within 2 hours of taking this medication. These antacids can decrease the absorption of fexofenadine.

Tell your doctor if your symptoms do not improve after 1 week, if they worsen, or if they occur with a fever.

Side Effects

Dizziness, trouble sleeping, nausea, or headache may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

An empty tablet shell may appear in your stool. This effect is harmless because your body has already absorbed the medication.

If your doctor has prescribed this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: fast/irregular/pounding heartbeat, shaking (tremor), mental/mood changes (such as anxiety, confusion, nervousness, restlessness), problems urinating.

Get medical help right away if you have any very serious side effects, including: seizures.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking this medication, tell your doctor or pharmacist if you are allergic to fexofenadine or pseudoephedrine; or if you have any other allergies. Also, tell your doctor if you have had serious side effects from similar medications (such as other decongestants, including phenylephrine). This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: glaucoma, difficulty urinating (such as due to an enlarged prostate), high blood pressure (hypertension), heart/blood vessel disease (such as coronary artery disease), overactive thyroid (hyperthyroidism), diabetes, kidney disease.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially fast/irregular heartbeat, dizziness, problems urinating, trouble sleeping, or confusion.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

Check the labels on all your medicines (such as cough-and-cold products) because they may contain similar ingredients (decongestants such as phenylephrine). Ask your pharmacist about using those products safely.

This medication may interfere with certain lab tests (such as allergy skin testing), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.

Does Allegra-D 12 Hour interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fast/irregular heartbeat, mental/mood changes (such as anxiety, restlessness), seizures.

Keep all medical and lab appointments.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Different brands of this medication may have different storage needs. Check the product package for instructions on how to store your brand, or ask your pharmacist. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Allegra-D 12 Hour 60 mg-120 mg tablet,extended release

Color: tan,whiteShape: oblongImprint: 06/012D

This medicine is a tan white, oblong, film-coated, tablet imprinted with “06/012D”.

Allegra-D 12 Hour 60 mg-120 mg tablet,extended release

Color: tan,whiteShape: oblongImprint: 06/012D

This medicine is a tan white, oblong, film-coated, tablet imprinted with “06/012D”.

Allegra-D 12 Hour 60 mg-120 mg tablet,extended release

Color: tan,whiteShape: oblongImprint: 06/012D

This medicine is a tan white, oblong, film-coated, tablet imprinted with “06/012D”.

Next

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Drug Survey

Have you ever purchased Allegra-D 12 Hour?

Yes, In the past 3 months

Yes, In the past 6 months

Yes, In the past year

Haven’t purchased but considering

Don’t plan to purchase

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Allegra: price, dosage and instructions for the drug for allergies

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Dosage

• Fexofenadine: 120 mg/tablet (1)
• Fexofenadine: 180 mg/tablet (1)

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• Older (2)
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• Type 6. 50 UAH

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Editorial group

Creation date: 04/27/2021
Date updated: 25.07.2023

Stock and release form

Stock

• Allegra 120 mg – oral speech: fexofenadine hydrochloride

1 tablet fexofenadine hydrochloride 120 mg (equivalent to 112 mg fexofenadine) rat, hydromelose, povidone, titanium dioxide (E 171), silicon dioxide coloid, macrogol 400, sumish saliva to erysipelas oxide (E 172) and sumis saliva to erysipelas oxide (E 172).

• Allegra 180 mg – oral speech: fexofenadine hydrochloride

1 tablet fexofenadine hydrochloride 180 mg (equivalent to 168 mg fexofenadine) rat, hydromelose, povidone, titanium dioxide (E 171), silicon dioxide coloid, macrogol 400, sumish saliva to erysipelas oxide (E 172) and sumis saliva to erysipelas oxide (E 172).

Release form

Covered with shell.

№ 10 № 20 (10 × 2) 10 tablets in a blister, 1 or 2 blister in a cardboard box.

Pharmacological action

Pharmacodynamics

Fexofenadine hydrochloride – non-sedative antihistamine effect of a group of specific H1 receptor antagonists. Fexofenadine є pharmacologically active metabolite of terfenadine.

In clinical studies of bulbs and hyperemia of the tongue, induced by histamine, the antihistamine effect of fexofenadine hydrochloride, which was prescribed 1 and 2 times for doba, manifested itself for 1:00, reaching a maximum after 6: 00 and three times for 24 years. The sign of the development of intolerance was not revealed after the 28-day intake. The clinical effect in case of allergy was observed after a single dose of 10 to 130 mg. In this model of antihistaminic efficacy for the prevention of a permanent effect for 24 years, doses of at least 130 mg were required. The maximum suffocation of swelling and hyperemia exceeded 80%. Clinical studies of seasonal allergic rhinitis show that a dose of 120 mg is sufficient to ensure 24-year efficacy

In patients with seasonal allergic rhinitis who received a dose of up to 240 mg of fexofenadine hydrochloride 2 times a day for 2 days, no statistically significant change in QT interval was observed in the same placebo group.

Similar changes were not observed in healthy volunteers in the same placebo match in healthy volunteers who took up to 60 mg of fexofenadine hydrochloride 2 times a day for 6 months, 400 mg of fexofenadine hydrochloride 2 times a day for a day 6.5 days i 240 mg per doba in a stretch. There were no statistically significant changes in the QT interval compared with placebo after ingestion of fexofenadine hydrochloride at a dose of 60 mg 2 times per day for 2 days.

At blood plasma concentrations that exceeded therapeutic concentrations by a factor of 32, fexofenadine in humans did not show any effect on the potassium channel of increased directing, cloning from the human myocardium.

Pharmacokinetics

Fexofenadine hydrochloride is easily wetted after taking it in the middle. The maximum concentration is reached in 1-3 years. The maximum concentration becomes approximately 289 ng / ml after a single dose of the drug at a dose of 120 mg 1 time per dose and approximately 494 ng / ml after a single dose of the drug at a dose of 180 mg 1 time per dose.

60-70% of fexofenadine binds to plasma proteins.

Fexofenadine is not metabolized in the liver. Metabolized in an unknown world, shards in the section and potassium are the main speech of the drug. Visnovok of fexofenadine in blood plasma is observed with a two-phase decrease and a terminal period of drinking from 11 to 15 years after the bagatoria stagnation. The kinetics of single-dose and bagatorase doses is linear at oral doses up to 120 mg 2 times per doba.

According to the data taken at the moment, a large part of the dose is taken from the liver, but in the meantime it will be taken up to 10%.

Indications before congestion

• Allegra 120 mg – Symptomatic treatment of seasonal allergic rhinitis in adults and children over 12 years of age.
• Allegra 180 mg – Symptomatic relief of chronic idiopathic croup for adults and children over 12 years of age.

Contraindications

• Increased sensitivity to fexofenadine hydrochloride or to other components of the drug.
• Vіk up to 12 roіv through vіdsutnіst obligatory danih s safety and efficiency.

Dose schedule

• Allegra 120 mg 120 mg 1 time per doba.
• Allegra 180 mg – The recommended dose of fexofenadine hydrochloride for adults and children over 12 years of age is 180 mg per doba in one dose, then one tablet of 180 mg 1 time per doba.

Overdose

Confusion, drowsiness, restlessness and dryness of the mouth have been reported as a result of an overdose of fexofenadine hydrochloride. In pairs with placebo, doses up to 60 mg twice per day for 2 days in children, as well as single doses up to 800 mg, and doses of 690 mg 2 times for doba for 1 month, as well as 240 mg 1 time for doba for 1 year in healthy volunteers did not reveal any clinically significant side effects. The maximum tolerated dose of fexofenadine hydrochloride has not yet been established.

In times of significant overdose, symptomatic relief and control of vital functions were observed. The use of fexofenadine hydrochloride in the blood for additional hemodialysis is not effective. So far, it is unknown about the basis of the antidote to the drug.

Adverse reactions

Adverse reactions that have been observed in older adults during follow-up clinical records, differences in organ systems and frequency of occurrence: very often (> 1 /10), often (> 1/100, <1/10), infrequently (> 1/1000, <1/100), rarely

(> 1/10000, <1/1000), sometimes rare (<1/10000), frequency not found.

To the side of the nervous system. Often: headache, drowsiness, confusion.

To the side of the intestinal tract. Often boring. Frequency not found: dry mouth.

Hot injuries and reactions in the area of ​​introduction. Infrequently increased stomly.

Time of post-marketing alert reported about lower adverse effects in adults (the frequency of these effects is unknown and cannot be estimated based on evidence)

systems. Reactions of hypersensitivity, which were manifested in an angioedema swelling, visible tightness in the chest, buttocks, flushes and other systemic anaphylactic reactions.

From the side of the psyche. Sleeplessness, nervousness, sleep disturbance or nightmares / non-primary dreaming (sick dreaming).

3rd side of the heart. Tachycardia, heartbeat.

To the side of the intestinal tract. Diarrhea.

From the side of the top and bottom of the cage. Visip, kropivyanka, sverbizh.

Warning about suspected side reactions. Notification about the suspicion of side reactions after the approval of the drug test is an important procedure. Tse allows you to continue monitoring the spivvіdnoshnennia melancholy / risk for this medical problem. Medical practitioners are guilty of informing about all suspected adverse reactions through the national alert system.

Special indications

Congestion during pregnancy and breastfeeding

Vagnancy. Data about the stagnation of women in women is not enough. Numerous studies on animals do not indicate the presence of direct or indirect influx on vaginess, embryonic / fetal development, canopies or postnatal development. Fexofenadine hydrochloride cannot be congested during the period of pregnancy, or in case of extreme need, if the measles for the mother is overwhelmed by the possible risk for the fetus.

Breastfeeding. While fexofenadine passes into breast milk, Allegra® 120 mg cannot be absorbed during breastfeeding.

Children

The drug should not be administered to children under 12 years of age.

The risk of influencing the severity of the reaction when caring for by motor transport or other mechanisms

at the building, caring for a car or working with mechanisms was not revealed. There was no testing of the total injection of Allegra® 120 mg on the function of the central nervous system for an hour. Patients can be cared for by car or can be cared for by a robot, which requires concentration of respect.

However, if there is evidence of increased sensitivity to the drug, it is recommended to review the patient’s individual reaction to the drug in advance.

Interaction with other medical conditions and other forms of interaction cym path.

Combinations that prevent side calls in case of congestion blood. Splashing on the QT-interval is not buv povyazany z tsієyu zminoy; the frequency of adverse reactions did not increase in the same period with the use of dermal sciatica okremo. Studies on experimental animals have shown that an increase in the concentration of fexofenadine in the blood plasma, as a result of a one-hour ingestion of erythromycin or ketoconazole, may be due to an increase in the inoculation of the drug in the gut tract and change either excretion of the drug in the zhovchnyh ways, or yogo secretion in the intestinal tract.

Interaction with omeprazole not established.

Shlunkovo-intestinal problems of masteva, antacid and adsorbent. The stagnation of antacids, in order to avenge aluminum hydroxide or magnesium, 15 minutes before taking the drug Allegra ® 120 mg reduces the effectiveness of fexofenadine hydrochloride, ymovirno through yogo binding in the mucosal-intestinal tract, thyself changing the soaking of fexofenadine in the intestinal tract. Follow the interval (more than 2:00 if possible) between the intake of fexofenadine hydrochloride and mucosal-intestinal diseases.

Wash Safety

Store in original packaging at temperatures below 25°C out of the reach of children. The term of appurtenance – 3 years.

Allegra instructions

ALLEGRA® 120 MG
(UA/8500/01/01)

Release form:

tablets, coated with a shell, 120 mg No. 10, No. 20 (10×2): 10 tablets in a blister; 1 or 2 blisters in a cardboard box

Stock:

1 tablet fexofenadine hydrochloride 120 mg (equivalent to fexofenadine 112 mg)

Manufacturer:

France

ALLEGRA® 180 MG
(UA/8500/01/02)

Release form:

tablets, coated with a shell, 180 mg No. 10, No. 20 (10×2): 10 tablets in a blister; 1 or 2 blisters in a cardboard box

Stock:

1 tablet fexofenadine hydrochloride 180 mg (equivalent to fexofenadine 168 mg)

Manufacturer:

France

Allegra price in Pharmacy 911

Name	Price
Allegra 180 tab. i.v. 180mg №10	143.20 UAH
Allegra 120 tab. i.v. 120mg №10	116.60 UAH

Antacids in fixed combinations – a marketing ploy of the manufacturer or a synergy of multifactorial action?

partners

Keywords / keywords:

Antacids, Gastro esophageal reflux disease, Gastroenterology, Proton pump inhibitors, Acid-dependent diseases, almagel

The use of antacids in modern gastroenterological practice is due to the convenience of the release forms, the speed of onset of action and the nature of the impact in the relief of symptoms such as heartburn, stomach pain, discomfort in the upper gastrointestinal tract, as well as the possibility of using in a variety of nosologies.

One of the most commonly diagnosed digestive disorders is gastroesophageal reflux disease (GERD). The basis of pharmacological therapy for GERD is drugs aimed at reducing the acidity of gastric juice, including antacids. Taking into account the data of the gastroenterological communities, the use of antacids involves symptomatic treatment on demand or in the period until the diagnosis is verified and the main therapy is prescribed [1].

One of these drugs is Almagel® (algeldrate + magnesium hydroxide), as well as its fixed combinations: Almagel® A (algeldrate + benzocaine + magnesium hydroxide), recommended for severe pain syndrome, and Almagel® Neo (algeldrate + magnesium hydroxide + simethicone), used for concomitant flatulence.

It is important to note that the effect of Almagel® is not limited to the neutralization of gastric hydrochloric acid. The multifactorial effect of the drug is associated with a decrease in pepsin activity, an enveloping and adsorbing effect, as well as a cytoprotective effect on the gastric mucosa due to stimulation of prostaglandin synthesis [2].

Symptoms of diseases of the gastrointestinal tract (GIT) are very variable, which is often mediated by difficulties in making a diagnosis before using instrumental diagnostic methods and, accordingly, prescribing pathogenetic treatment. At the same time, pain is a key symptom of dyspepsia in gastroduodenitis and peptic ulcer disease [3, 4]. The local anesthetic component of the drug Almagel® A, benzocaine, has minimal absorption when administered orally, while it can begin to act 1-2 minutes after administration [5], which can play a significant role in improving the quality of life and the patient’s ability to work.

Combined therapy of gastroenterological diseases can be the mainstay of treatment for comorbid conditions. It has been demonstrated that the incidence of GERD symptoms in irritable bowel syndrome (IBS) is 4 times higher than in patients without IBS [6]. One of the explanations for the increased prevalence of GERD in IBS is the common pathophysiological mechanisms and the increase in the number of diagnostic studies after the diagnosis of IBS [7-9]. In addition to pain and stool disorders, IBS is often accompanied by flatulence against the background of fermentative and/or putrefactive dyspepsia [10]. It is important to note that IBS and GERD can also be combined with functional dyspepsia, additional criteria for which include concomitant functional heartburn and flatulence [11, 12]. The combined drug Almagel® Neo helps to relieve the symptoms of heartburn and bloating, reducing not only acidity in the stomach, but also gas formation, which may help alleviate the patient’s condition [13].

What benefit does the patient derive from multifactorial action.

When diagnosing gastrointestinal diseases associated with increased production of hydrochloric acid, in addition to complaints of heartburn and belching, patients may pay attention to pain and bloating [11, 14].

Comorbid conditions require the appointment of additional drugs, which can reduce patient compliance and, accordingly, the effectiveness of treatment [15]. Fixed combinations of drugs of the Almagel® line provide ease of use, allow you to cover a larger symptom complex [5, 13] and choose the optimal combination depending on the individual characteristics of the course of diseases and accompanying symptoms.

1. Katz PO, Dunbar KB, Schnoll-Sussman FH, et al. ACG Clinical Guideline for the Diagnosis and Management of Gastroesophageal Reflux Disease. Am J Gastroenterol. 2022;117(1):27-56.
2. Instructions for medical use of the drug Almagel®: P N012742/01
3. Ivashkin V.T., Maev I.V., Lapina T.L., et al. Clinical recommendations of the Russian Gastroenterological Association and the association “Endoscopic Society RANDO” for the diagnosis and treatment of gastritis, duodenitis. Russian journal of gastroenterology, hepatology, coloproctology. 2021;31(4):70-99.
4. Ivashkin V.T., Maev I.V., Tsarkov P.V., et al. Diagnosis and treatment of peptic ulcer in adults (Clinical recommendations of the Russian Gastroenterological Association, the Russian Society of Colorectal Surgeons and the Russian Endoscopic Society). Russian journal of gastroenterology, hepatology, coloproctology. 2020;30(1):49-70.
5. Instructions for medical use of the drug Almagel® A: P N012741/01
6. Lovell RM, Ford A. Prevalence of gastro-esophageal reflux-type symptoms in individuals with irritable bowel syndrome in the community: A meta-analysis. Am. J. Gastroenterol. 2012;107:1793–801.
7. Lai YT, Chen CY, Bair MJ. Epidemiology, Clinical Features, and Prescribing Patterns of Irritable Bowel Syndrome in Taiwan. Front Pharmacol. 2021;12:788-95.
8. Jones MP, Shah A, Walker MM, el al. Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities. Neurogastroenterol Motil. 2022;34(9):e14349.
9. de Bortoli N, Tolone S, Frazzoni M, et al. Gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome: common overlapping gastrointestinal disorders. Ann Gastroenterol. 2018;31(6):639-48.
10. Ivashkin V.T., Maev I.V., Shelygin Yu.A., et al. Diagnosis and treatment of irritable bowel syndrome (Clinical recommendations of the Russian Gastroenterological Association and the Russian Association of Coloproctologists). Russian journal of gastroenterology, hepatology, coloproctology. 2021;31(5):74-95.
11. Ivashkin V.T., Maev I.V., Sheptulin A.A., et al. Clinical guidelines of the Russian gastroenterological association for the diagnosis and treatment of functional dyspepsia. Russian journal of gastroenterology, hepatology, coloproctology. 2017;27(1):50-61.
12. Black CJ, Paine PA, Agrawal A, et al. British Society of Gastroenterology guidelines on the management of functional dyspepsia. gut. 2022;71(9):1697-723.
13. Instructions for medical use of the drug Almagel® Neo: P N013310/01
14. Ivashkin V.T., Maev I.V., Kucheryavy Yu.A., et al. Clinical recommendations of the Russian gastroenterological association for the management of patients with abdominal pain.