What are the uses of Amoxicillin 250mg capsules. How does Amoxicillin work against bacterial infections. What are the common side effects of Amoxicillin 250mg. When should you not take Amoxicillin capsules. How should Amoxicillin be taken and stored properly.

Understanding Amoxicillin 250mg Capsules

Amoxicillin 250mg capsules are a widely prescribed antibiotic medication used to treat various bacterial infections. As part of the penicillin family, this powerful antibiotic works by inhibiting bacterial cell wall synthesis, effectively stopping the growth and multiplication of harmful bacteria. Healthcare providers often prescribe Amoxicillin for its broad-spectrum activity against many common pathogens.

These capsules contain amoxicillin as the active ingredient, typically manufactured by pharmaceutical companies like Zydus Healthcare Limited. The medication is generally available in strips of 10 capsules and comes with a standard return policy for patient convenience.

Key Uses and Indications for Amoxicillin 250mg

Amoxicillin 250mg capsules are indicated for treating a range of bacterial infections affecting different parts of the body. Some primary uses include:

• Respiratory tract infections (lungs and airways)
• Tonsillitis and throat infections
• Skin and soft tissue infections
• Urinary tract infections
• Sexually transmitted infections like gonorrhea
• Prevention of stomach ulcers caused by Helicobacter pylori

It’s crucial to note that Amoxicillin is only effective against bacterial infections and should not be used for viral illnesses such as the common cold or flu. Misuse of antibiotics can lead to antibiotic resistance, a growing concern in global healthcare.

How Amoxicillin Works to Combat Bacterial Infections

Amoxicillin belongs to the beta-lactam class of antibiotics, which includes penicillins and cephalosporins. Its mechanism of action involves:

1. Binding to penicillin-binding proteins (PBPs) in bacterial cell walls
2. Inhibiting the final stage of bacterial cell wall synthesis
3. Weakening the cell wall structure, leading to bacterial cell lysis and death

This process effectively stops the growth and multiplication of susceptible bacteria, allowing the body’s immune system to clear the infection more efficiently. The broad-spectrum nature of Amoxicillin makes it effective against many common bacterial pathogens, both gram-positive and gram-negative.

Common Side Effects and Precautions

While Amoxicillin is generally well-tolerated, some patients may experience side effects. Common adverse reactions include:

• Nausea and vomiting
• Diarrhea
• Skin rash or itching
• Headache
• Yeast infections (in some cases)

Most of these side effects are mild and resolve on their own. However, patients should be aware of more serious reactions, such as severe allergic responses or antibiotic-associated diarrhea. It’s essential to inform your healthcare provider of any unusual or persistent side effects.

Precautions and Contraindications

Certain individuals should exercise caution or avoid using Amoxicillin 250mg capsules altogether. These include:

• People with known allergies to penicillins or cephalosporins
• Patients with a history of antibiotic-associated colitis
• Individuals with severe kidney disease
• Pregnant or breastfeeding women (use only under medical supervision)

Always inform your healthcare provider about your medical history, current medications, and any allergies before starting Amoxicillin treatment.

Proper Dosage and Administration Guidelines

The correct dosage of Amoxicillin 250mg capsules depends on several factors, including the type and severity of the infection, the patient’s age, weight, and overall health status. Typical adult dosages range from 250mg to 500mg taken every 8 hours, but this can vary based on the specific condition being treated.

Key Points for Proper Administration:

• Take the capsules whole with a full glass of water
• Do not chew, crush, or break the capsules
• Follow the prescribed dosing schedule consistently
• Complete the entire course of treatment, even if symptoms improve
• Avoid taking more than the prescribed dose

Are there any special instructions for taking Amoxicillin with food? Amoxicillin can be taken with or without food. However, taking it with food may help reduce stomach upset in some patients. Consistency in administration (always with food or always without) can help maintain steady drug levels in the body.

Potential Drug Interactions and Considerations

Amoxicillin can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. Some notable interactions include:

• Oral contraceptives (may reduce effectiveness)
• Anticoagulants like warfarin (may increase bleeding risk)
• Probenecid (can increase Amoxicillin levels in the blood)
• Allopurinol (may increase the risk of skin rashes)
• Methotrexate (Amoxicillin may affect its elimination)

To minimize the risk of drug interactions, always inform your healthcare provider about all medications, supplements, and herbal products you are taking. This includes over-the-counter drugs and vitamins.

Alcohol Consumption

While there is no direct interaction between Amoxicillin and alcohol, consuming alcohol while taking antibiotics can potentially slow down the recovery process and exacerbate certain side effects like nausea and dizziness. It’s generally advisable to avoid or limit alcohol consumption during antibiotic treatment.

Storage and Handling of Amoxicillin 250mg Capsules

Proper storage of Amoxicillin is crucial to maintain its effectiveness and safety. Follow these guidelines:

• Store at room temperature, below 25°C (77°F)
• Keep in a cool, dry place away from direct sunlight
• Store in the original packaging to protect from moisture
• Keep out of reach of children and pets
• Do not use after the expiration date printed on the package

What should you do with unused or expired Amoxicillin capsules? Proper disposal of unused or expired antibiotics is important to prevent environmental contamination and antibiotic resistance. Return unused medication to a pharmacy for proper disposal, or follow local guidelines for medication disposal.

Special Considerations for Specific Patient Groups

While Amoxicillin is generally safe for most patients, certain groups require special consideration:

Pregnancy and Breastfeeding

Amoxicillin is considered relatively safe during pregnancy and breastfeeding, but should only be used under medical supervision. The benefits of treatment must be weighed against potential risks to the fetus or infant.

Elderly Patients

Older adults may be more susceptible to certain side effects and may require dose adjustments, especially if they have reduced kidney function. Close monitoring is often necessary in this population.

Patients with Kidney Disease

Amoxicillin is primarily excreted through the kidneys. Patients with impaired renal function may require dose adjustments to prevent drug accumulation and potential toxicity.

Children

Pediatric dosing of Amoxicillin is based on the child’s weight and the severity of the infection. Liquid formulations are often preferred for younger children who may have difficulty swallowing capsules.

How does the dosage differ for children compared to adults? Children typically require weight-based dosing, often ranging from 20-90 mg/kg/day divided into 2-3 doses, depending on the infection being treated. Adult dosages are generally fixed and based on the type and severity of the infection.

Monitoring and Follow-up During Amoxicillin Treatment

Proper monitoring during Amoxicillin treatment is essential to ensure effectiveness and detect any potential complications. Key aspects of monitoring include:

• Assessing symptom improvement within 48-72 hours of starting treatment
• Watching for signs of allergic reactions or severe side effects
• Monitoring for superinfections, especially in prolonged courses
• Checking kidney function in at-risk patients or those on high doses

When should you contact your healthcare provider during treatment? Patients should reach out to their healthcare provider if they experience severe side effects, no improvement in symptoms after a few days, or worsening of the infection despite taking the medication as prescribed.

Follow-up Care

After completing a course of Amoxicillin, follow-up care may include:

1. A final check-up to confirm resolution of the infection
2. Repeat cultures or tests in certain cases (e.g., urinary tract infections)
3. Discussion of preventive measures to avoid recurrent infections
4. Addressing any lingering symptoms or concerns

Regular follow-up helps ensure complete resolution of the infection and allows for early detection of any potential complications or recurrences.

Antimicrobial Stewardship and Responsible Use of Amoxicillin

The responsible use of antibiotics like Amoxicillin is crucial in combating the global threat of antibiotic resistance. Antimicrobial stewardship programs aim to promote the appropriate use of antibiotics, minimize side effects, and preserve their effectiveness for future generations.

Key Principles of Antimicrobial Stewardship:

• Using antibiotics only when necessary and appropriate
• Choosing the right antibiotic for the specific infection
• Using the correct dose and duration of treatment
• Avoiding unnecessary antibiotic use for viral infections
• Educating patients about proper antibiotic use and disposal

How can patients contribute to antimicrobial stewardship? Patients can play a crucial role by taking antibiotics exactly as prescribed, not sharing antibiotics with others, and not using leftover antibiotics from previous treatments. Additionally, patients should avoid pressuring healthcare providers for antibiotics when they may not be necessary, such as for viral infections.

The Impact of Antibiotic Resistance

Antibiotic resistance occurs when bacteria evolve to survive exposure to antibiotics, making infections harder to treat. This can lead to:

• Longer hospital stays
• More expensive treatments
• Increased mortality rates for certain infections
• Limited treatment options for serious infections

By using antibiotics responsibly, we can help slow the development of resistance and preserve these life-saving medications for future generations.

Alternatives and Complementary Approaches to Antibiotic Treatment

While Amoxicillin is an effective treatment for many bacterial infections, there are situations where alternative approaches may be considered:

Alternative Antibiotics

In cases of Amoxicillin allergy or resistance, healthcare providers may prescribe alternative antibiotics such as:

• Macrolides (e.g., azithromycin, clarithromycin)
• Fluoroquinolones (e.g., ciprofloxacin, levofloxacin)
• Tetracyclines (e.g., doxycycline)
• Cephalosporins (for patients without severe penicillin allergy)

Complementary Approaches

In addition to antibiotic treatment, certain complementary approaches may support recovery and boost the immune system:

• Adequate rest and hydration
• Proper nutrition rich in vitamins and minerals
• Probiotics to support gut health during antibiotic treatment
• Stress reduction techniques to support overall immune function

Can natural remedies replace antibiotic treatment? While some natural remedies may provide symptomatic relief, they should not replace prescribed antibiotic treatment for bacterial infections. Always consult with a healthcare provider before combining alternative treatments with prescribed medications.

Preventive Measures

Preventing infections in the first place can reduce the need for antibiotic use. Some preventive strategies include:

• Practicing good hygiene, including regular handwashing
• Staying up-to-date with vaccinations
• Maintaining a healthy lifestyle to support immune function
• Avoiding close contact with individuals who have contagious infections

By combining responsible antibiotic use with preventive measures and complementary approaches, patients can optimize their treatment outcomes while contributing to the broader goal of antimicrobial stewardship.

Amoxil 250 MG Capsule (10): Uses, Side Effects, Price & Dosage

By ZYDUS HEALTHCARE LIMITED

10 Capsule(s) in Strip

7 days return policyRead More

All the Products are packed and stored Safely

Amoxil 250 MG Description

Amoxil 250mg capsule is an antibiotic medicine. It is used to treat bacterial infections of the lungs, airways, tonsils, throat, skin, and urinary tract. It contains amoxicillin as an active ingredie

nt. Amoxil 250mg capsule stops the growth and multiplication of bacteria. Antibiotics should not be used when not sure if the infection is due to bacteria. The unnecessary use of antibiotics can make the treatment ineffective. You should always complete the entire course of treatment with antibiotics to prevent the risk of re-infection. Inform your doctor about your medical history and if you are pregnant, planning a pregnancy, or are breastfeeding before starting this medicine.

Product Summary

Offer Price	₹23. 49
You Save	₹1.24 (5% on MRP)
Contains	Amoxycillin / Amoxicillin(250.0 Mg)
Uses	Bacterial infections
Side effects	Diarrhoea, nausea, vomiting, rashes
Therapy	ANTIBIOTIC

Check more medicines with composition as Amoxycillin / Amoxicillin(250.0 Mg)

Uses of Amoxil 250 MG

• Amoxil 250mg capsule is used for the treatment of bacterial infections of the airway, lungs, skin, tonsils, throat, and urinary tract.

• It is used for the treatment of sexually transmitted diseases like gonorrhea.

• It is also used for reducing the risk of ulcers due to a bacteria called H. pylori.

Contraindications of Amoxil 250 MG

• If you are allergic to amoxicillin or other components of Amoxil 250mg capsule.

• If you have a history of allergic reactions to penicillins or cephalosporins. If you are not sure what these medicines are, please confirm with your doctor.

Side effects of Amoxil 250 MG

• Nausea

• Vomiting

• Diarrhoea

• Skin rash

• Skin itching

Precautions and Warnings of Amoxil 250 MG

Pregnancy

Q:

Can I take Amoxil 250mg capsule during pregnancy?

A:

There is limited information about the effect of Amoxil 250mg capsule during pregnancy. You can use the medicine during pregnancy only if prescribed by the doctor.

Breast Feeding

Q:

Can I take Amoxil 250mg capsule while breastfeeding?

A:

Amoxil 250mg capsule passes into the human breastmilk. You can use the medicine during breastfeeding only if prescribed by the doctor.

Driving

Q:

Can I drive if I have consumed Amoxil 250mg capsule?

A:

There is limited information available on the effect of Amoxil 250mg capsule on the driving ability. If you experience any side effects after taking this medicine that may affect your ability to drive safely, it is suggested to avoid driving.

Alcohol

Q:

Can I consume alcohol with Amoxil 250mg capsule?

A:

There is limited information available on the interaction of alcohol with Amoxil 250mg capsule. Ask your doctor for advice on the use of alcohol with Amoxil 250mg capsule.

Other General Warnings

Talk to your doctor if

• You experience allergic symptoms after taking the medicine.

• You have kidney disease.

• You experience fits or seizures.

• You are unable to urinate or have difficulty urinating.

• You have glandular fever and experience symptoms like fever, extreme tiredness, sore throat, and swollen glands.

• You experience watery or bloody diarrhoea and fever, even after stopping the medicine.

Mode of Action of Amoxil 250 MG

How Does It Work?

Amoxil 250mg capsule blocks the action of an enzyme responsible for cell wall formation in bacteria, thereby stopping the growth and multiplication of bacteria responsible for the infection.

Directions for Use of Amoxil 250 MG

• Amoxil 250mg capsule should be taken as directed by the doctor.

• Take it as a whole with a glass of water.

• Do not cut, break or chew it.

• Complete the entire course of treatment as prescribed by your doctor.

• Do not take more than the prescribed dose.

Interactions of Amoxil 250 MG

Interactions with other medicines

• Some medicines can affect the way Amoxil 250mg capsule works, or the medicine itself can reduce the effectiveness of other medicines taken at the same time.

• Inform the doctor of medicines, supplements, or herbals you are taking or might take to avoid possible interaction.

• Particular care should be taken if you are taking other anti-infective medicines, medicines for the treatment of gout, and oral contraceptives.

Storage and disposal of Amoxil 250 MG

• Store Amoxil 250mg capsule below 25°C in a cool and dry place.

• Keep it away from children and pets.

Dosage of Amoxil 250 MG

Overdose

The symptoms of an overdose of Amoxil 250mg capsule include nausea, diarrhoea, and vomiting. In case of an overdose, contact the doctor immediately or visit the nearest hospital.

Missed a Dose

You should never miss your dose of antibiotics as it may lead to treatment failure and relapse of the infection. If you miss a dose of Amoxil 250mg capsule, take it as soon as you remember. However, if it’s time for the next dose, skip the missed dose and continue with the medicine schedule….

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Frequently Asked Questions (FAQs)

Q: Is Amoxil 250mg capsule safe to use in pregnancy?

A: Amoxil 250mg capsule can be taken by a pregnant woman if prescribed by a doctor. Avoid self-medicating, especially during pregnancy since there is limited safety information available about the use of the medicine during pregnancy. Consult the doctor before taking medicine.

Q: What is Amoxil 250mg capsule used for?

A: Amoxil 250mg capsule is an antibiotic used for treating infections of the lungs, throat, airways, ears, tonsils, urinary tract, certain reproductive tract infection (gonorrhoea) and to reduce the risk of recurrence of an ulcer due to a bacteria, H. pylori.

Q: For how many days should I take Amoxil 250mg?

A: You should take Amoxil 250mg capsule for the exact dose and duration as recommended by your doctor. You should complete the entire course of this medicine. Do not stop taking this medicine on your own even if you feel better.

Q: Is Amoxil 250mg a painkiller?

A: No, Amoxil 250mg capsule is not a painkiller. It is an antibiotic medicine of the beta-lactam class of antibiotics. It contains amoxicillin as the active substance.

• Novamox Capsules [Internet]. CiplaMed. 2022 [cited 20 Apr 2022]
• Amoxicillin 250 mg Capsules – Summary of Product Characteristics (SmPC) – (emc) [Internet]. Medicines.org.uk. 2022 [cited 20 Apr 2022]
• Amoxicillin 250 mg Capsules – Patient Information Leaflet (PIL) – (emc) [Internet]. Medicines.org.uk. 2022 [cited 20 Apr 2022]
• DailyMed – AMOXICILLAN tablet [Internet]. Dailymed.nlm.nih.gov. 2022 [cited 20 Apr 2022]
• CDSCO [Internet]. Cdscoonline.gov.in. 2022 [cited 20 Apr 2022]

Product Details

Brand

AMOXIL

Expires on or After

30/12/2023

• AMOXIL 250 MG INJECTION 2 ML
• AMOXIL 500MG STRIP OF 10 CAPSULES
• AMOXIL 125 MG DRY SYRUP 100 ML
• AMOXIL 250MG CAPSULE
• AMOXIL 500 MG INJECTION 2 ML
• AMOXIL DT 250MG STRIP OF 10 TABLETS
• AMOXIL KID 250 MG TABLET 10
• AMOXIL DT 125MG STRIP OF 10 TABLETS
• AMOXIL KID 125 MG TABLET 10

Last Updated on: 22 Apr 2022 | 07:26 PM (IST)

Disclaimer

The information provided herein is supplied to the best of our abilities to make it accurate and reliable as it is published after a review by a team of professionals. This information is solely intended to provide a general overview on the product and must be used for informational purposes only. You should not use the information provided herein to diagnose, prevent, or cure a health problem. Nothing contained on this page is intended to create a doctor-patient relationship, replace or be a substitute for a registered medical practitioner’s medical treatment/advice or consultation. The absence of any information or warning to any medicine shall not be considered and assumed as an implied assurance. We highly recommend that you consult your registered medical practitioner for all queries or doubts related to your medical condition. You hereby agree that you shall not make any health or medical-related decision based in whole or in part on anything contained in the Site. Please click here for detailed T&C.

Amoxicillin 250 mg (sold per capsule)

What is Amoxicillin?

Amoxicillin is a broad-spectrum penicillin antibiotic used to treat various infections caused by susceptible strains of bacteria. Amoxicillin is sold per capsule or per tablet and requires a prescription from your veterinarian.

NOTE: Amoxicillin is also available in a suspension as Amoxicillin Drops.

For:

Cats and Dogs

Benefits:

• Broad-spectrum antibiotic that treats a wide array of bacterial infections
• Treats ear infections, urinary tract infections, and skin infections (infected bite wounds)
• Also effective against upper respiratory, bladder, and dental infections
• Sold per capsule or per tablet

How does amoxicillin work?

Amoxicillin works by inhibiting the formation of bacterial cell walls.

Cautions:

Tell your veterinarian if your pet is being given another antibiotic. Also tell your veterinarian if your pet has allergies, or kidney, stomach or intestinal disease. While symptoms may subside early, use all of the prescribed medicine.

Brand Name:

Amoxil (GlaxoSmithKline), Biomox (Delmarva), Robamox-BV (Fort Dodge), Trimox (Apothecon)

Generic Name:

amoxicillin

What is the most important thing I should know about Amoxicillin?

Amoxicillin is a prescription medication available as 100 mg and 400 mg tablets, 250 mg and 500 mg capsules. Amoxicillin Drops suspension is also available in a 15 ml bottle. The usual dose of amoxicillin in dogs and cats is 5-10 mg/lb every 12-24 hours. Contact your veterinarian immediately if your pet develops severe or bloody diarrhea. Give all of the amoxicillin that is prescribed for your pet, since symptoms may begin to improve before the infection is completely treated.

What should I discuss with my veterinarian before giving amoxicillin to my pet?

Tell your veterinarian if your pet has ever had an allergic reaction to another penicillin or to a cephalosporin. Tell your veterinarian if your pet has kidney disease or stomach or intestinal disease.

How should amoxicillin be given?

Give this medication exactly as directed by your veterinarian. Amoxicillin can be given with or without food. Give all of the amoxicillin even if your pet appears to be better. Symptoms may improve before the infection is completely treated.

What are the potential side effects of amoxicillin?

Contact your veterinarian immediately if the pet experiences severe or bloody diarrhea during treatment. Stop giving amoxicillin and seek emergency veterinary medical care in the event of an allergic reaction (shortness of breath; hives; swelling of the lips, tongue, or face; rash; or fainting), seizures, unusual bleeding, or bruising. Other less serious side effects such as mild nausea, vomiting, diarrhea or abdominal pain, or yeast or fungal infection may be more likely to occur. Continue to give amoxicillin and notify your veterinarian if these symptoms occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.

What happens if I miss giving a dose of amoxicillin?

Give the missed dose as soon as you remember unless it is almost time for the next regularly scheduled dose. Do not give a double dose unless otherwise directed by your veterinarian.

What happens if I overdose my pet on amoxicillin?

Seek emergency veterinary medical treatment if an overdose is suspected. Symptoms of overdose may include muscle spasms or weakness, pain or twitching, seizures, confusion, coma, or agitation.

What should I avoid while giving amoxicillin to my pet?

There are no restrictions on food or activity during treatment with amoxicillin unless otherwise directed by your veterinarian.

What other drugs will affect amoxicillin?

Before giving amoxicillin, tell your veterinarian if your pet is being given another antibiotic (for the same or a different infection), allopurinol, or probenecid. You may not be able to give amoxicillin or you may need to have the dosage adjusted. Drugs other than those listed here may also interact with amoxicillin. Talk to your veterinarian or pharmacist before giving any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.

Amoxicillin capsules 250mg No. 16 (9 pieces) at a low price in Omsk, instructions for use, composition, analogues 010

Active ingredient :

Amoxicillin 250 mg (as trihydrate).

Excipients:

Magnesium stearate

Microcrystalline cellulose pH 102

250 mg capsule composition:

Titanium Dioxide E171

Quinoline Yellow E 104

Azorubine E 122

Patent Blue V E 131

Brilliant Black E 151

900 04 Gelatin

Pharmacological action

Amoxicillin – antibacterial acid-resistant bactericidal spectrum of action from the group of semi-synthetic penicillins.

Inhibits transpeptidase, disrupts the synthesis of peptidoglycan (supporting cell wall protein) during division and growth, causes bacterial lysis.

Due to the broad spectrum of action, the drug is active against both gram-positive and gram-negative microorganisms.

Clinically significant amoxicillin-susceptible Gram-negative organisms include Escherichia coli, Proteus mirabilis, Salmonella, Shigella, Campylobacter, Haemophilus influenzae, Bordetella pertussis, Leptospira, Chlamydia.

In addition, amoxicillin is active against all microorganisms sensitive to penicillin G, for example, streptococci of groups A, B, C, G, H, I, M, Streptococcus pneumoniae, staphylococci and Neisseria spp., not

penicillinase-producing, Erysipelothrix rhysiopathiae, Corynebacterium, Bacillus anthracis, Actinomycetes, Streptobacilli, Spirillium minus, Pastereulla multocida, Listeria, Spirochaeta (Leptospira, Treponema, Borrelia) and others,

as well as various anaerobic microorganisms (including peptococci, peptostreptococci , clostridia and fusobacteria).

Pharmacokinetics

Absorption – fast, high (93%), food intake does not affect absorption, is not destroyed in the acidic environment of the stomach.

When taken orally at a dose of 125 and 250 mg, the maximum concentration is 1.5-3 mcg / ml and 3.5-5 mcg / ml, respectively.

The action develops 15-30 minutes after application and lasts 8 hours. The time to reach the maximum concentration after oral administration is 1-2 hours.

It has a large volume of distribution – high concentrations are found in plasma, sputum, secret distribution is weak), pleural and peritoneal fluid, urine,

contents of skin blisters, lung tissue, intestinal mucosa, female genital organs, prostate gland, middle ear fluid, bone, adipose tissue, gallbladder (with normal liver function), fetal tissues.

Doubling the dose also doubles the concentration. The concentration in bile exceeds the concentration in plasma by 2-4 times.

In the amniotic fluid and umbilical cord vessels, the concentration of amoxicillin is 25-30% of the level in the plasma of a pregnant woman.

Poorly penetrates the blood-brain barrier, with inflammation of the meninges (meningitis), the concentration in the cerebrospinal fluid is about 20%. Communication with plasma proteins – 17%.

Partially metabolized to inactive metabolites. The half-life is 1-1.5 hours.

Small amounts are excreted in breast milk. In case of impaired renal function (creatinine clearance less than or equal to 15 ml / min), the half-life increases to 8.5 hours.

Amoxicillin is removed by hemodialysis.

Active ingredients

Amoxicillin

Indications

Bacterial infections caused by susceptible microflora:

• respiratory and ENT infections (sinusitis, pharyngitis, tonsillitis, acute otitis media, bronchitis, pneumonia),
• genitourinary system (pyelonephritis, pyelitis, cystitis, urethritis, gonorrhea, endometritis, cervicitis),
• gastrointestinal tract (peritonitis, enterocolitis, typhoid fever, cholangitis, cholecystitis),
• skin and soft tissue infections (erysipelas, impetigo, secondarily infected dermatoses),
• leptospirosis,
• listeriosis,
• Lyme disease (borreliosis),
• dysentery, almonellosis,
• salmonellosis,
• meningitis,
• endocarditis (prophylaxis),
• sepsis.

Use in pregnancy and lactation

Amoxicillin may be used during pregnancy when the benefit to the mother outweighs the potential risk to the fetus.

Amoxicillin is excreted in breast milk in low concentrations.

If necessary, the use of the drug during lactation should decide on the termination of breastfeeding.

Contraindications

• Hypersensitivity to the components of the drug (including other penicillins, cephalosporins, carbapenems),
• allergic diseases (including history),
• bronchial asthma, 900 94
• pollinosis,
• infectious mononucleosis,
• lymphocytic leukemia,
• liver failure,
• colitis associated with the use of antibiotics, including history,
• lactation period, body less than 40 kg.

Precautions

Precautions – pregnancy, allergic reactions (including history), diseases of the gastrointestinal tract in history, renal failure, as well as indications of a history of bleeding.

Side effects

Allergic reactions:

skin rash, flushing, itching, urticaria, erythema, angioedema, rhinitis, conjunctivitis. fever, joint pain, eosinophilia, exfoliative dermatitis, exudative polyform

erythema, Stevens-Johnson syndrome. reactions similar to serum sickness, toxic epidermal necrolysis, generalized exanthematous pustulosis, allergic vasculitis, anaphylactic shock.

From the digestive system:

dysbacteriosis, change in taste, vomiting, nausea, diarrhea, stomatitis, glossitis, abnormal liver function, moderate increase in liver transaminases, cholestatic jaundice, hepatic cholestasis, acute cytolytic hepatitis, pseudomembranous colitis.

From the nervous system:

agitation, anxiety, insomnia, ataxia, confusion, behavior change, depression, peripheral neuropathy, headache, dizziness, convulsions.

Laboratory indicators:

leukopenia, neutropenia, thrombocytopenic purpura, anemia.

Other:

shortness of breath, tachycardia, interstitial nephritis, crystalluria, eosinophilia, agranulocytosis, vaginal candidiasis, superinfection (especially in patients with chronic diseases or reduced body resistance).

Interactions

Pharmaceutically incompatible with aminoglycosides (cannot be mixed to avoid mutual inactivation).

Antacids, glucosamine, laxatives, food, aminoglycosides – delay and reduce absorption. ascorbic acid increases absorption.

Bactericidal antibiotics (including aminoglycosides, cephalosporins, cycloserine, vancomycin, rifampicin) – synergistic action. bacteriostatic drugs (macrolides, chloramphenicol, lincosamides, tetracyclines, sulfonamides) antagonistic.

Increases the effectiveness of indirect anticoagulants (suppressing the intestinal microflora, reduces the synthesis of vitamin K and prothrombin index). reduces the effectiveness of estrogen-containing oral contraceptives,

drugs, during the metabolism of which paraaminobenzoic acid is formed, ethinyl estradiol – the risk of breakthrough bleeding.

Diuretics, allopurinol, oxyphenbutazone, phenylbutazone, non-steroidal anti-inflammatory drugs. drugs that block tubular secretion – reducing tubular secretion, increase the concentration.

Allopurinol increases the risk of skin rash.

Reduces clearance and increases methotrexate toxicity.

Increases the absorption of digoxin.

How to take, course of administration and dosage

Inside, before or after meals.

Adults and children over 10 years of age (weighing over 40 kg) are prescribed 500 mg 3 times a day. in severe infections – 750 mg – 1 g 3 times a day.

In acute uncomplicated gonorrhea, 3 g is given as a single dose. in the treatment of women, repeated administration of the indicated dose is recommended.

In acute infectious diseases of the gastrointestinal tract (paratyphoid, typhoid fever) and biliary tract, in gynecological infectious diseases for adults – 1.5-2 g 3 times a day or 1-1.5 g 4 times a day.

Adults with leptospirosis – 0.5-0.75 g 4 times a day for 6-12 days.

In case of salmonella carriage in adults – 1.5-2 g 3 times a day for 2-4 weeks.

For the prevention of endocarditis in minor surgical interventions in adults – 3-4 g 1 hour before the procedure. If necessary, a second dose is prescribed after 8-9 hours.
In children, the dose is reduced by 2 times.

In patients with impaired renal function with creatinine clearance of 15-40 ml / min, the interval between doses is increased to 12 hours with creatinine clearance below 10 ml / min, the dose is reduced by 15-50%. with anuria – the maximum dose is 2 g / day.

Overdose

Symptoms: nausea, vomiting, diarrhea, water and electrolyte imbalance (as a result of vomiting and diarrhea).

Treatment: gastric lavage, activated charcoal, saline laxatives, drugs to maintain fluid and electrolyte balance. hemodialysis.

Indication

Antibiotic-penicillin

Special instructions

Special instructions

During course treatment, it is necessary to monitor the state of the function of the hematopoietic organs, liver and kidneys. Perhaps the development of superinfection due to the growth of microflora insensitive to it, which requires a corresponding change in antibiotic therapy.

When administered to patients with bacteremia, a bacteriolysis reaction (Jarish-Herxheimer reaction) may develop.

In patients who are hypersensitive to penicillins, allergic cross-reactions with cephalosporin antibiotics are possible.

Antidiarrheal drugs that reduce intestinal motility should be avoided in the treatment of mild diarrhea during the course of treatment. kaolin- or attapulgite-containing antidiarrheals may be used. For severe diarrhea, see a doctor.

Treatment necessarily continues for another 48-72 hours after the disappearance of clinical signs of the disease.

When using estrogen-containing oral contraceptives and amoxicillin at the same time, other or additional methods of contraception should be used whenever possible.

Product form

Capsules

Storage conditions

In a dry, dark place at a temperature of 15 to 25 °C.

Keep out of reach of children.

Shelf life

3 years.