Health benefits, uses, risks, and side effects

Aspirin is a common drug for relieving minor aches, pains, and fevers. People also use it as an anti-inflammatory or blood thinner.

People can buy aspirin over the counter without a prescription. Everyday uses include relieving headache, reducing swelling, and reducing a fever.

Taken daily, aspirin can lower the risk of cardiovascular events, such as a heart attack or stroke, in people with a high risk. Doctors may administer aspirin immediately after a heart attack to prevent further clots and heart tissue death.

This article provides an overview of aspirin, including its uses, risks, interactions, and possible side effects.

Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). It was the first of this class of drug to be discovered.

Aspirin contains salicylate, a compound found in plants such as the willow tree and myrtle. Its use was first recorded around 4,000 years ago.

Hippocrates used willow bark for relieving pain and fevers, and some people still use willow bark as a natural remedy for headaches and minor pain.

NSAIDs are a class of drug with the following effects:

• relieving pain
• reducing fever
• lowering inflammation, in higher doses

These drugs are not steroids. Steroids often have similar benefits to NSAIDs, but they are not appropriate for everyone and can have unwanted side effects.

As analgesics, NSAIDs tend to be non-narcotic. This means that they do not cause insensibility or a stupor.

Aspirin is a trademark owned by the German pharmaceutical company Bayer. The generic term for aspirin is acetylsalicylic acid.

Aspirin has many uses, including relieving pain and swelling, managing various conditions, and reducing the risk of cardiovascular events in people with a high risk.

Below, we describe these uses in more details.

Pain and swelling

Aspirin can relieve mild to moderate pain, swelling, or both associated with many health issues, such as:

• headaches
• a cold or flu
• sprains and strains
• menstrual cramps
• long-term conditions, such as arthritis and migraine

For severe pain, a doctor may recommend using aspirin alongside another drug, such as an opioid pain reliever or another NSAID.

Preventing cardiovascular events

The daily use of low-dose aspirin can lower the risk of cardiovascular events in some people — it is not safe for everyone. The Food and Drug Administration (FDA) recommend only using aspirin in this way under the supervision of a doctor.

In people with a high risk of cardiovascular events, low-dose aspirin can reduce the risk by preventing blood clots from forming.

A doctor may recommend daily low-dose aspirin for people who :

• have a heart or blood vessel disease
• have evidence of poor blood flow to the brain
• have high blood cholesterol
• have high blood pressure, or hypertension
• have diabetes
• smoke

However, for people without these issues, the risks of long-term aspirin use can outweigh the benefits.

The 2016 recommendations from the United States Preventive Services Task Force say that adults aged 50–59 may take aspirin daily to prevent colorectal cancer, as well as cardiovascular disease. However, this guidance only applies to adults in the age range who:

• have at least a 10% 10-year risk of cardiovascular disease
• do not have a high risk of bleeding
• have a life expectancy of at least 10 years
• are willing to take a daily low dose for at least 10 years

Treating coronary events

Doctors may administer aspirin immediately after a heart attack, stroke, or another cardiovascular event to prevent further clot formation and cardiac tissue death.

Aspirin can also be part of a treatment plan for people who have recently had:

• revascularization surgery, such as an angioplasty or coronary bypass surgery
• a mini-stroke, or transient ischemic attack
• an ischemic stroke, which is caused by a blood clot

Other uses

Aspirin can also help treat pain and swelling associated with the following chronic health conditions:

• rheumatic conditions, including rheumatoid arthritis, osteoarthritis, and other inflammatory joint conditions
• systemic lupus erythematosus
• inflammation around the heart, known as pericarditis

Doctors may recommend low-dose aspirin to people:

• with retinal damage, also called retinopathy
• who have had diabetes for more than 10 years
• who are taking antihypertensive medications
• with a risk of colorectal cancer

Doctors do not usually recommend aspirin for people under 18.

This is because it can increase the risk of a serious condition called Reye’s syndrome, which can appear after a viral infection such as a cold, the flu, or chickenpox. Reye’s syndrome can lead to permanent brain injury or death.

However, a clinician may prescribe aspirin to a child under supervision if they have Kawasaki disease or to prevent blood clots from forming after heart surgery.

For children, doctors usually recommend acetaminophen (Tylenol) or ibuprofen (Advil), in appropriate doses, instead of aspirin.

People with the following conditions should be cautious about taking aspirin, and should only do so if a doctor recommends it:

• bleeding disorders, such as hemophilia
• uncontrolled high blood pressure
• asthma
• peptic or stomach ulcers
• liver or kidney disease

Under a doctor’s supervision, people who are pregnant or breastfeeding may take low-dose aspirin. Doctors usually do not recommend high-dose aspirin during pregnancy.

Anyone with a known allergy to aspirin or any other NSAID, such as ibuprofen, should avoid these drugs.

Doctors do not administer aspirin during a stroke because not all strokes are caused by blood clots. In some cases, aspirin could make a stroke worse.

Also, anyone who drinks alcohol regularly or is undergoing dental or surgical treatment, however small, should ask a doctor before taking aspirin.

An interaction may involve one medication making another less effective or the combination being dangerous.

Aspirin can interact with many drugs. Some of these include:

• Anti-inflammatory painkillers: Examples include such as diclofenac, ibuprofen, and naproxen. Combined with aspirin, these types of drugs can increase the risk of stomach bleeding.
• Selective serotonin reuptake inhibitors and other antidepressants: Examples include citalopram, fluoxetine, paroxetine, venlafaxine, and sertraline. In combination with aspirin, any of these can increase the risk of bleeding.
• Warfarin: In combination with this blood thinner, aspirin can reduce the drug’s anticoagulant effects and increase the risk of bleeding. There are situations, however, when this combination may be beneficial.
• Methotrexate: In combination with this drug, used in the treatment of cancer and some autoimmune diseases, aspirin can make the drug harder to eliminate, potentially resulting in levels of methotrexate that are toxic.

For a more complete list of drug interactions, check with the National Institute for Health and Care and Excellence.

The most common side effects of aspirin are:

• stomach or gut irritation
• indigestion
• nausea

The following adverse effects are less common:

• worsening asthma symptoms
• vomiting
• stomach inflammation
• stomach bleeding
• bruising

Aspirin can also have very serious side effects, such as bleeding in the brain or stomach or kidney failure. A rare side effect of daily low-dose aspirin is hemorrhagic stroke.

Aspirin can help prevent and treat a range of health issues, but people under 18 should not take it without medical guidance.

Aspirin is available over the counter or by prescription. Always follow the instructions on the label or a doctor’s guidance. This is especially crucial for people who may be more likely to experience adverse effects.

Aspirin is not safe for everyone, especially in a daily dosage. Other options for mild pain relief include other NSAIDs, such as ibuprofen, and acetaminophen.

Read the article in Spanish.

Side effects of low-dose aspirin

Like all medicines, low-dose aspirin can cause side effects, although not everyone gets them.

Common side effects

Common side effects of low-dose aspirin happen in more than 1 in 100 people. There are things you can do to help cope with them.

Mild indigestion

Take your aspirin with food. If the indigestion still does not go away, it could be a sign that the aspirin has caused a stomach ulcer. Talk to your doctor – they may prescribe something to protect your stomach or switch you to a different medicine.

Bleeding more easily than normal

Because aspirin helps to stop your blood from clotting, it can sometimes make you bleed more easily. For example, you may get nosebleeds and bruise more easily, and if you cut yourself, the bleeding may take longer than normal to stop. Be careful when doing activities that might cause an injury or a cut. Always wear a helmet when cycling. Wear gloves when you use sharp objects like scissors, knives, and gardening tools. Use an electric razor instead of wet shaving, and use a soft toothbrush and waxed dental floss to clean your teeth. See a doctor if you’re worried about any bleeding.

Talk to your doctor or pharmacist if the side effects bother you or do not go away:

Serious side effects

It happens rarely, but some people have serious side effects after taking aspirin.

Call your doctor or call 111 now if:

• you are coughing up blood or have blood in your pee, poo or vomit
• the whites of your eyes turn yellow or your skin turns yellow (this may be less obvious on brown or black skin), or your pee gets darker – these can be signs of liver problems
• the joints in your hands and feet become painful – this can be a sign of high levels of uric acid in the blood
• your hands or feet swell – this can be a sign of water retention

Stomach ulcers

Aspirin can cause ulcers in your stomach or gut, especially if you take it for a long time or in big doses.

Your doctor may tell you not to take aspirin if you have a stomach ulcer, or if you’ve had one in the past.

If you’re at risk of getting a stomach ulcer and you need a painkiller, take paracetamol instead of aspirin as it’s more gentle on your stomach.

Serious allergic reaction

In rare cases, it’s possible to have a serious allergic reaction (anaphylaxis) to aspirin .

Immediate action required: Call 999 now if:

• your lips, mouth, throat or tongue suddenly become swollen
• you’re breathing very fast or struggling to breathe (you may become very wheezy or feel like you’re choking or gasping for air)
• your throat feels tight or you’re struggling to swallow
• your skin, tongue or lips turn blue, grey or pale (if you have black or brown skin, this may be easier to see on the palms of your hands or soles of your feet)
• you suddenly become very confused, drowsy or dizzy
• someone faints and cannot be woken up
• a child is limp, floppy or not responding like they normally do (their head may fall to the side, backwards or forwards, or they may find it difficult to lift their head or focus on your face)

You or the person who’s unwell may also have a rash that’s swollen, raised, itchy, blistered or peeling.

These can be signs of a serious allergic reaction and may need immediate treatment in hospital.

Other side effects

These are not all the side effects of aspirin. For a full list see the leaflet inside your medicines packet.

Information:

You can report any suspected side effect using the Yellow Card safety scheme.

Visit Yellow Card for further information.

Page last reviewed: 16 December 2021

Next review due: 16 December 2024

Aspirin allergy: causes, symptoms and treatment

Aspirin allergy – symptoms and treatment. Find out what drugs can cause an aspirin allergy and what to do if you experience this problem. How does cross-allergy manifest itself and how can it be prevented?

Aspirin is a drug known to many as a remedy for pain and fever. In addition, it is used to prevent heart disease due to its ability to thin the blood. Aspirin is generally considered safe to use, but some people may develop an allergy to the drug.

Aspirin allergy is more common in adults, especially in people with chronic conditions such as asthma or rhinitis. One of the most common symptoms of aspirin allergy is asthma attacks.

This text will tell you about the causes, symptoms, and treatments for an aspirin allergy. We will discuss what an aspirin allergy is, what causes it, what symptoms it can present with, and what to do if you suspect you have an aspirin allergy.

What is an aspirin allergy?

An aspirin allergy is an immune system reaction to medicines containing aspirin or its derivatives. It manifests itself in the form of various symptoms, including skin rash, itching, swelling, runny nose, asthma, and even anaphylactic shock.

Aspirin allergy usually develops in patients who have previously had a reaction to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs). This is due to the fact that these drugs contain the same group of chemical compounds that are substituents of the cyclooxygenase (COX) system.

The COX system is responsible for the production of prostaglandins, which are involved in the regulation of inflammatory processes, pain reactions and thermoregulation of the body. When interacting with aspirin, some forms of the COX system are blocked, which leads to a decrease in the production of prostaglandins and a decrease in inflammatory processes.

However, when allergic to aspirin, the blockage of the COX system causes a strong reaction of the immune system, which manifests itself in the form of allergic symptoms.

It is important to remember that an allergy to aspirin is a serious condition that can lead to complications. Therefore, if any suspicious symptoms appear, you should consult a doctor and conduct the necessary studies to establish a diagnosis.

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How does aspirin cause allergies?

Aspirin is a medicine that contains acetylsalicylic acid. It is well tolerated by most people, but may cause allergic reactions in some. An allergy to aspirin can present with a variety of symptoms.

In the body, aspirin is converted into other substances, including acetylsalicylic acid. This acid affects the production of a substance called prostaglandin. Prostaglandin, in turn, can cause an allergic reaction.

When allergic to aspirin, the body’s immune system perceives acetylsalicylic acid as a threat and begins to produce antibodies. Upon subsequent contact with aspirin, the antibodies cause an allergic reaction, which can manifest itself in a variety of ways.

Depending on the individual’s sensitivity, allergic reactions to aspirin can range from minor symptoms such as itching or skin rashes to serious allergic reactions such as anaphylaxis. Therefore, it is important to seek medical help at the first symptoms of an allergy to aspirin.

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Q&A:

What is an aspirin allergy?

An aspirin allergy is the body’s reaction to taking aspirin, which manifests itself as an allergic reaction. Allergy symptoms can be varied and often unpredictable, and can range from mild to severe.

What are the causes of aspirin allergy?

The causes of aspirin allergy are not fully understood. However, some studies show that in some cases, the development of allergies may be associated with increased activity of mast cells and basophils, which play a role in the immune system.

What are the symptoms of an allergy to aspirin?

Symptoms of aspirin allergy may include runny nose, cough, rhinitis, laryngeal oedema, breathing difficulties, chest pain, nausea, vomiting, headache, dermatitis, urticaria, and anaphylaxis. Symptoms may be mild or severe.

What diagnosis is used to diagnose aspirin allergy?

Diagnostic methods include skin test, immunological tests and immunofluorescence microscopy. In some cases, an aspirin test is required, followed by observation of the patient by a doctor for 30 minutes to detect a reaction to aspirin.

How can aspirin allergy be treated?

Treatment of aspirin allergy may include the use of alternative drugs such as paracetamol, ibuprofen, or nasal drops. Immunotherapy or the use of angionephrotic inhibitors may also be prescribed.

How to prevent the development of allergy to aspirin?

Prevention of aspirin allergy may include avoiding aspirin and aspirin analogues. If you have had a reaction to aspirin, you should tell your doctor so that he can determine if you have an allergy and prescribe alternative medications.

What are the consequences of ignoring an aspirin allergy?

If an allergy to aspirin is ignored, it can lead to anaphylaxis, a severe and life-threatening allergic reaction. Anaphylaxis can cause a heart attack, breathing problems, and even death, so if you develop allergy symptoms, see your doctor right away.

Who is allergic to aspirin?

Aspirin allergy can occur in people of any age and gender. However, there are groups of people who are at a higher risk of developing an allergy to aspirin:

• People with asthma – those with asthma have a higher risk of developing an allergy to aspirin.
• People with a hereditary tendency – if there are people in the family who are allergic to aspirin, other family members may be at a higher risk of developing this allergy.
• People with adverse reactions to other NSAIDs – People who have had adverse reactions to other NSAIDs may be at a higher risk of developing an allergy to aspirin.
• Women – Women have a higher risk of developing an allergy to aspirin than men.

If you have any of the risk factors listed above, it is important to avoid taking aspirin without talking to your doctor. If signs of an allergic reaction appear, seek medical attention immediately.

What are the symptoms of an allergy to aspirin?

An aspirin allergy is an immune system reaction to a substance in aspirin that can cause a variety of symptoms.

1. Skin symptoms: rash, itching, redness or swelling appears on the skin. Angioedema, which is swelling of the skin and mucous membranes, can develop and can be a life-threatening condition.
2. Respiratory symptoms: manifest as coughing, shortness of breath, wheezing in the chest, asthmatic attacks, or stenosis of the larynx. Some people experience similar symptoms when aspirin comes into contact with the skin or is applied to the eyes.
3. Gastrointestinal symptoms: The presence of abdominal pain, vomiting, diarrhea or gastritis indicates an allergic reaction to aspirin. Allergy sufferers may also experience non-specific abdominal discomfort and nausea.

Symptoms of aspirin allergy may begin within 30 minutes of contact with aspirin or other preparations containing salicylates. In rare cases, the reaction may start later and even after a few days.

Your doctor may schedule special skin and blood tests to check for an aspirin allergy.

How is aspirin allergy diagnosed?

Aspirin allergy can present with a variety of symptoms and can be difficult to diagnose. However, to diagnose aspirin allergy, doctors use several methods:

1. Allergy tests – includes skin tests and tests for aspirin-specific antibodies in the blood. A skin test may involve applying a small amount of aspirin to the skin and assessing the reaction to it.

2. Aspirin test – Your doctor may suggest an aspirin test to see if you have an allergy or not. This test is performed in a medical facility under the supervision of a doctor.

3. Medical history – The doctor will take a complete medical history to understand what symptoms are present and how quickly they appear after taking aspirin.

An accurate diagnosis will help you choose the right treatment and avoid the risk of unwanted side effects. If you notice symptoms of an allergy to aspirin, be sure to consult a doctor so that he can prescribe adequate treatment.

How can I prevent an allergy to aspirin?

Aspirin allergy can occur in anyone at any age. You may have already experienced unpleasant symptoms after taking aspirin or other preparations containing it as an active ingredient. But don’t despair! There are several ways you can help prevent or reduce your risk of an aspirin allergy.

• See your doctor – If you have experienced allergic reactions to medications, you should tell your doctor. He or she can help you find an alternative drug without aspirin.
• Avoid self-medication – do not take medicine containing aspirin without a doctor’s prescription. Do not forget that aspirin is found not only in pain pills, but also in anticoagulants, anti-inflammatory drugs, cold and flu remedies, as well as in other dosage forms.
• Predict Your Allergies – Do an allergy test to see if your body reacts to aspirin. This will help you prevent possible troubles in the future.
• Be careful when buying products – aspirin is found not only in medicines, but also in some products, such as nuts, spices and fruits. So if you’re sensitive to aspirin, find out which foods to avoid.

Remember that if you have already had an allergic reaction to aspirin, you should avoid using it in any form. It is important to follow all the recommendations of the doctor and be careful when choosing products and medicines.

How is an allergy to aspirin treated?

Treatment for aspirin allergy depends on how severe the symptoms are. If the symptoms are mild, it may be sufficient to avoid drugs that contain aspirin and replace them with others that do not cause an allergic reaction. If the symptoms are more severe, then special treatment will be required.

Antihistamines, which reduce the production of histamine and reduce allergic symptoms, can be used to treat aspirin allergy. These drugs can be taken as tablets, drops, or injections.

If the allergic reaction to aspirin is severe and can lead to anaphylaxis, more serious treatment may be needed. Anaphylaxis can be treated with epinephrine, corticosteroids, inhaled medications, and other medications that help reduce swelling and reduce the risk of serious consequences.

However, the most effective way to treat aspirin allergy is to avoid exposure to the drug. If you have had an allergic reaction to aspirin in the past, you should tell your doctor and avoid it in the future. Also, make sure you always know which medicines contain aspirin and let your doctor know when prescribing medications.

What medicines can be taken instead of aspirin?

If allergic to aspirin, some people have difficulty choosing alternative medicines. However, there are several safe and effective substitutes for aspirin that can reduce pain and fever:

• Paracetamol is a safe and effective medicine for pain and fever;
• Ibuprofen – often used to reduce pain and fever. However, use it carefully in children and the elderly, as it may cause unwanted side effects;
• Naproxen is a safe drug for reducing pain symptoms and fever. However, like ibuprofen, it can cause unwanted side effects;
• Acetaminophen is a safe and effective alternative to aspirin at a safe moderate dosage. However, a high dose of acetaminophen can be harmful to the liver and cause serious side effects;
• Corticosteroids – along with anti-inflammatory effects, drugs such as prednisolone, dexamethasone and hydrocortisone can be used as a substitute for aspirin to treat allergic reactions. However, the appointment of a course of corticosteroids should be carried out only by a doctor.

Do not forget that when choosing an aspirin substitute, you must take into account the individual characteristics of the body and consult a doctor.

What problems can occur if you are allergic to aspirin?

Aspirin is a very popular drug often used as an analgesic, antipyretic and anti-clotting agent. Although it is a safe drug for most people, some people may have an allergic reaction to aspirin.

The main signs of allergy to aspirin are skin rash, itching, runny nose, cough, bronchospasm, breathing problems, bruises. Some people may experience anaphylactic shock, a potentially fatal condition that requires immediate medical attention.

Finding an allergy to aspirin can be a serious problem when taking medications for other illnesses. Many other medications contain aspirin, so people who are allergic to aspirin may have trouble taking them. People who are allergic to aspirin should definitely discuss this with their doctor to avoid possible problems.

Anyone who is allergic to aspirin should be sure to tell their doctor before taking a group of drugs such as non-steroidal anti-inflammatory drugs (NSAIDs). Some of these medicines contain aspirin and may increase the allergic reaction.

It is very important to take precautions when using medications and if you are allergic to aspirin. People who are allergic to aspirin should be sure to familiarize themselves with all the formulations of the drugs they intend to use to make sure that there is no aspirin or other ingredients that can cause an allergic reaction.

What should I do if I have an allergic reaction to aspirin?

The first and most important step is to stop using aspirin. If signs of an allergic reaction occur, seek medical attention immediately.

In case of acute form of allergy it is necessary to call an ambulance and start treatment in the hospital. Doctors may prescribe glucocorticosteroids, epinephrine, antihistamines, or other medications, depending on the form of the allergic reaction.

If the allergy is less severe stop taking aspirin immediately and take an antihistamine. Immediate use of antihistamines will help minimize the effects of an allergic reaction.

If you know you are allergic to aspirin, never take it on your own. Be sure to tell your doctor about your diagnosis and write this in your medical record.

Try to avoid the use of medicines containing aspirin. There are alternative drugs that can be used to treat and relieve pain. However, if you have been prescribed aspirin as a preventative, be sure to tell your doctor about your diagnosis and arrange for another medication.

What foods should I avoid if I’m allergic to aspirin?

If you are allergic to aspirin, be careful what you eat. Some foods may contain salicylates, which are similar to aspirin and may cause an allergic reaction.

Salicylates are found in the following foods:

• Fruits: apples, grapes, apricots, peaches, strawberries, oranges, lemons and other fruits.
• Vegetables: tomatoes, peppers, cucumbers, spinach and other vegetables.
• Nuts and seeds: pine nuts, peanuts, hazelnuts and other types of nuts.
• Spices and herbs: mint, cloves, coriander, etc.
• Beverages: tea, coffee, special sodas, etc. for aspirin. To determine which product specifically causes a reaction, you need to see a doctor and get tested.

  What medicines and products can contain aspirin?

  Aspirin (acetylsalicylic acid) is one of the most widely used drugs in the world due to its analgesic, antipyretic and anti-inflammatory properties. However, not everyone knows that aspirin can be present not only as a separate drug, but also as part of many other medicines and everyday products.

  Some of the more common medicines containing aspirin include:

  • Analgesics such as Aspirin, Aspicor, Citramon and Ibuprofen;
  • Anti-fever preparations such as Atecan, Rubetsedin, Fervex;
  • Drugs to reduce the number of platelets in the blood, such as Ticlostasis, Cardiomagnyl, Aspicard;
  • Preparations for the treatment of diseases of the cardiovascular system, such as Coronal, Melaxen, Excarp;
  • Medicines for the treatment of rheumatic diseases such as Aloprin, Azamun, Leflunomide.

  In addition, aspirin can also be found in everyday products, such as:

  • Some types of toothpaste, such as Sensodin, Betadine;
  • Products for the treatment of skin problems such as Ibusplast, Ibuferm;
  • Gastrointestinal drugs such as Mezim, Festal, Espumizan;
  • Products for the prevention of colds, such as Combigripp, Sinupret;
  • Mood improvement products such as Bronchomax, Duphaston, Pajindetal.

  It is important to check the composition of medicines and products before using them to avoid undesirable health effects.

  How is retreatment after an allergic reaction to aspirin?

  Caution should be exercised when retreating after an allergic reaction to aspirin, as a repeated allergic reaction may be more severe and dangerous.

  Before re-treatment, it is necessary to consult a specialist and carry out an aspirin tolerance test. Testing allows you to determine the presence of an allergic reaction to aspirin and determine the safe dose for treatment.

  In cases where the test shows an allergy to aspirin, the doctor may recommend changing the medicine to other drugs, such as naproxen, ibuprofen or paracetamol. But in this case, it is also necessary to be careful and pass a test for the tolerance of this drug.

  • Retreatment after an allergic reaction to aspirin can take place not only in the form of tablets, but also in the form of injections, solutions and other forms.
  • To minimize the risk of drug allergy, follow the recommendations of experts and limit the consumption of products containing salicylates – berries, nectars, fruits and tea.
  • Do not risk taking aspirin if you have not passed a tolerance test or have an allergic reaction to this drug.

  In the event of a repeated allergic reaction to aspirin, seek medical attention immediately. In such a situation, an ambulance and additional treatment are needed, as well as a review of the treatment regimen.

  Are there any contraindications for the use of aspirin?

  Yes, there are certain contraindications for the use of aspirin. First of all, it is an allergic reaction to this drug. When it appears, it is not recommended to continue the use of aspirin.

  Also, do not use aspirin in the presence of stomach and intestinal ulcers, as well as in their acute form. This drug can cause their exacerbation and aggravate the course of the disease.

  Aspirin is also undesirable in the presence of blood disorders such as thrombocytopenia, agranulocytosis, hemophilia and others. This is because aspirin can aggravate bleeding and lead to serious complications.

  Finally, aspirin is not recommended for pregnant women and children under 12 years of age.

  For whom is aspirin contraindicated?

  Aspirin is one of the most commonly used medicines for treating headaches, fever and inflammation, but some people may be allergic to this drug.

  Before using aspirin to treat your condition, you need to find out how safe it is for you. Ask your doctor or pharmacist for advice if you have any doubts.

  Aspirin is contraindicated for those suffering from asthma, tricolor or allergic reaction to aspirin, hives or mugwort.

  Aspirin can also be dangerous for people with peptic ulcers, asthma, and liver and kidney disease. Before using aspirin, be sure to consult your doctor, especially if you have any doubts about contraindications or dosage.

  How is aspirin allergy related to other allergies?

  Aspirin allergy can be associated with other allergies and is often part of a set of allergic reactions to foods and drugs.

  For example, people suffering from rhinitis, asthma, or eczema may experience an allergic reaction to aspirin. These diseases are associated with the body’s response to allergens in the environment.

  In addition, an allergic reaction to aspirin may be associated with an allergy to fruits and vegetables. Sometimes food allergens contain ingredients that are similar to aspirin. This can cause a reaction to aspirin in people who are not allergic to the medication.

  If a person is allergic to aspirin, care should be taken when taking other medicines. Analgesics, anti-inflammatory drugs, and drugs containing acetylsalicylic acid can cause an allergic reaction to aspirin. For such cases, it is better to consult a doctor before starting any new medications.

  It is also worth remembering that an allergy to aspirin is related to an allergy to NSAIDs (non-steroidal anti-inflammatory drugs). In this case, if you have previously had an allergic reaction to aspirin, then you should avoid taking such drugs.

  Aspirin’s Top 10 Side Effects

  Aspirin is perhaps the most commonly used pain reliever and antipyretic drug in the world for over 100 years, and has been trusted by mankind for over 100 years. But there are also spots on the Sun… What are the side effects of aspirin? Read our article.

  Forewarned means you won’t get sick

  Regardless of how long you use aspirin, there are certain side effects that can cause mild to serious health problems. If used incorrectly, even analgin could be harmful. We have selected the most frightening side effects of aspirin use: they may cause your at-risk patients to abandon this drug in favor of a safer NSAID for them.

  1. GI PROBLEMS. Aspirin is a fairly “corrosive” acid, the intake of which, even at the recommended dose, can cause, in addition to heartburn, nausea, vomiting and dyspepsia. Such symptoms are already a reason to see a doctor, since acetylsalicylic acid carries the risk of gastrointestinal bleeding and the development of peptic ulcer.

  An interesting and recent fact: Long-term aspirin leads to a lower risk of bleeding than short-term aspirin. Perhaps this is due to the fact that with short-term use, consumers are not particularly inclined to be careful with the dosage. However, many experts explain this paradox purely statistically, because patients who tolerate aspirin well continue to take it, while those who are subject to adverse effects quickly stop using salicylate – they fall into the sample.

  2. HEPATOTOXICITY. Aspirin has undesirable side effects on the liver and may adversely affect the detoxification function of this organ. Several forms of liver damage by acetylsalicylic acid have been studied. So, its high doses lead to a marked increase in the level of aminotransferase in the blood serum, which is accompanied by jaundice or signs of liver dysfunction. And at lower doses, aspirin can damage the liver in children susceptible to this salicylate.

  3. NEPHROTOXICITY. Regular use of aspirin can lead to the development of such a rare but dangerous pathology as analgesic nephropathy. It is characterized by necrosis of the renal papillae and inflammatory changes in the tubules and interstitial tissue. Analgesic nephropathy is not the last among the causes of chronic renal failure, since it often develops asymptomatically and, accordingly, remains without treatment.

  4. HEMORRHAGE AND HEMORRHAGIC STROKE. Aspirin is known to be used to prevent heart attacks and strokes by preventing thrombosis. But its use can provoke another stroke, hemorrhagic, caused by bleeding in the brain.

  Indications for the use of this drug for the prevention of ischemic strokes are not so clear. For example, the results of a recent and also large-scale study demonstrated that daily aspirin intake by healthy elderly people can … be harmful to health. And since millions take it just with the hope of improvement, the pharmacist should share this sensation with them. Many researchers today are talking about revising the standards for the use of acetylsalicylic acid for various indications, since even its short-term use can be fraught with problems.

  5. ALLERGIC REACTIONS. Many people are hypersensitive to aspirin and can develop life-threatening allergic reactions. For the same reason, acetylsalicylic acid should not be taken by patients with asthma: it can act as a trigger. Asthma attacks caused by this drug are severe, sometimes even leading to death.

  6. Gout attacks. Acetylsalicylic acid, used in low doses, can worsen the condition of people suffering from gout.

  7. TINNITUS is a fairly common condition characterized by tinnitus or ringing that appears to be caused by regular aspirin use. This problem cannot be considered trifling, since it is fraught with irreversible hearing loss.

  8. HIGH BLOOD PRESSURE. As a non-steroidal anti-inflammatory drug, aspirin may increase blood pressure levels. Patients with hypertension should only use it after consulting their doctor.

  9. CNS SYMPTOMS. Regular use of aspirin causes drowsiness, confusion and dizziness in some people. Although these are not serious side effects, they should not be ignored as they are fraught with long-term consequences – the harmful effects of aspirin on the central nervous system accumulate.

  10. REYE’S SYNDROME IN CHILDREN AND ADOLESCENTS is a rapidly progressive encephalopathy, a formidable complication that can lead to death. Sometimes also accompanied by liver damage. Unfortunately, Reye’s syndrome (aka Reye’s syndrome) is still one of the underestimated risks of using aspirin in pediatrics, despite the fact that childhood has long been included in the list of contraindications to its use. At the same time, different sources indicate a different age limit for the appointment of this NSAID – 11, 12 or even 15 years. However, given the fact that mortality in Reye’s syndrome reaches 50%, it is better to focus on the last figure. Moreover, NSAIDs such as ibuprofen and paracetamol successfully cope with high fever and other symptoms of a cold: for the symptomatic treatment of colds, chickenpox or to relieve pain, it is better to choose them.

  Additionally at risk…

  Pregnant and lactating women should also not take this drug: aspirin is harmful to the fetus – it can cause heart problems in the unborn child, cause weight loss or cause other serious consequences. Therefore, future mothers should consult with their doctor regarding the old, but not very good aspirin.

  Patients preparing for any, even minimal surgery, should avoid the use of this drug, as it has anticoagulant properties, and therefore can lead to dangerous bleeding during surgery.

  Ludmila Shvarts

  Vain hopes

  New horizons for the use of aspirin – prevention of carcinogenesis. So, for the last 15-20 years, this NSAID has been considered by researchers as a kind of anticarcinogenic agent with a mysterious mechanism of action. The results of dozens of previous trials have shown that its administration allegedly provided a preventive effect against certain forms of cancer, however, purely statistically.

  But the surprises don’t end there: other researchers are sure that aspirin… increases the risk of developing cancer. The authors of the latest work on this drug found an increase in mortality due to cancer in the aspirin-treated group. The authors believe that this phenomenon is due to the interaction of aspirin with the participants already had cancer at the preclinical stage, that is, undiagnosed.