Best otc sinus headache. Best OTC Sinus Decongestants: 7 Top Picks to Relieve Congestion and Headaches

03.08.202316.06.2023 by alexxlab

Discover the 7 best over-the-counter (OTC) sinus decongestants to relieve congestion, sinus pressure, and headaches from colds, flu, and allergies. Get expert recommendations and learn about the different types of decongestants and their potential side effects.

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Best OTC Sinus Decongestant for Allergies: Benadryl Allergy Plus Decongestant Ultratabs

Benadryl Allergy Plus Decongestant Ultratabs contain a combination of the antihistamine diphenhydramine and the decongestant phenylephrine. This makes them effective at relieving both allergy symptoms like sneezing and runny nose, as well as sinus congestion. Reviewers note these tablets work quickly and can be taken up to every 4 hours as needed. However, the drowsy effect of the diphenhydramine means they may not be suitable for days when you need to be alert.

Best OTC Decongestant for a Headache: Advil Sinus Congestion and Pain

Advil Sinus Congestion and Pain combines the decongestant phenylephrine with the pain reliever ibuprofen. This makes it an effective choice for sinus-related headaches, as it can relieve both the nasal swelling causing the congestion and the headache pain. Many reviewers find this medication works better than prescription options for their frequent sinus headaches. Just be mindful of the total ibuprofen dosage if taking other ibuprofen-containing products.

Best OTC Sinus Decongestant Nasal Spray: Afrin No Drip Severe Congestion

For fast-acting, targeted relief of sinus congestion, Afrin No Drip Severe Congestion nasal spray is a good option. The active ingredient oxymetazoline works quickly to shrink swollen nasal passages. Reviewers say it effectively clears up stuffiness, though it should not be used for more than 3 days in a row to avoid rebound congestion. This spray may also cause a burning or stinging sensation initially.

Best Sinus Decongestant for Kids: Little Remedies Decongestant Nose Drops

For children experiencing sinus congestion, Little Remedies Decongestant Nose Drops provide a safe, gentle option. The active ingredient phenylephrine helps reduce swelling in the nasal passages without the potential drowsiness of some oral decongestants. These come in a liquid dropper format that’s easy to administer to young children. Reviewers note the drops work well to clear up stuffiness without causing jitteriness.

Best OTC Decongestant Day/Night Duo: Sudafed PE Day and Night Sinus Pressure Tablets

Sudafed PE Day and Night Sinus Pressure Tablets offer a convenient two-part system. The daytime formula contains phenylephrine to relieve congestion, while the nighttime formula adds the antihistamine doxylamine to help promote sleep. This can be helpful for managing sinus issues around the clock. Reviewers appreciate the ability to target their symptoms at different times of day.

Best Sinus Decongestant on a Budget: Cabinet Nasal Decongestant Tablets

For an affordable OTC decongestant option, Cabinet Nasal Decongestant Tablets containing phenylephrine are a solid choice. They provide the same active ingredient as many name-brand decongestants at a lower cost. Reviewers find these tablets effective at relieving stuffiness, though they may experience some side effects like restlessness or dizziness.

Best OTC Decongestant for Bedtime: Mucinex Night Shift Cold and Flu

When sinus congestion is keeping you up at night, Mucinex Night Shift Cold and Flu can help. This combination medication contains the decongestant guaifenesin along with the antihistamine dextromethorphan to provide nighttime relief. Reviewers say it helps them breathe easier and fall asleep faster when dealing with cold or flu symptoms. Just be aware that the drowsy effects may linger into the morning.

No matter which OTC sinus decongestant you choose, be sure to follow the dosage instructions carefully and avoid using any nasal sprays for more than 3 days in a row. If your symptoms persist or worsen, it’s best to consult with your healthcare provider. With the right decongestant, you can find relief and get back to your daily routine.

What are the different types of OTC sinus decongestants and how do they work?
Decongestant ingredients like phenylephrine and pseudoephedrine work by constricting the blood vessels in the nasal passages to reduce swelling and improve airflow. Antihistamine ingredients like diphenhydramine block the body’s allergic response to reduce symptoms like sneezing and runny nose. Corticosteroid ingredients like fluticasone help reduce inflammation in the nasal passages.

What are the potential side effects of OTC sinus decongestants?
Common side effects of oral decongestants like phenylephrine and pseudoephedrine include restlessness, dizziness, and anxiety. Intranasal decongestants like oxymetazoline may cause a burning or stinging sensation, sore throat, and nosebleeds. Antihistamines like diphenhydramine can cause drowsiness. It’s important to carefully review the product label and avoid using these medications for more than a few days at a time.

How do I choose the best OTC sinus decongestant for my needs?
The best OTC sinus decongestant for you will depend on the specific symptoms you’re trying to relieve. If your main issue is nasal congestion from a cold or flu, a decongestant like phenylephrine may be most effective. If your congestion is due to allergies, an antihistamine-decongestant combination may work better. Consider factors like whether you need daytime or nighttime relief, and whether you’re prone to side effects like drowsiness. Reading product reviews can also help guide your decision.

7 Best Nasal Decongestants You can Get Over the Counter

We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.

Healthline only shows you brands and products that we stand behind.

Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:

Evaluate ingredients and composition: Do they have the potential to cause harm?
Fact-check all health claims: Do they align with the current body of scientific evidence?
Assess the brand: Does it operate with integrity and adhere to industry best practices?

We do the research so you can find trusted products for your health and wellness.

Decongestant type	Best for	Possible side effects
Phenylephrine decongestant	sinus congestion caused by cold and flu	restlessness, dizziness, anxiety
Pseudoephedrine decongestant	sinus congestion caused by cold and flu	restlessness, dizziness, anxiety, nausea, upset stomach
Intranasal decongestants	sinus congestion caused by cold and flu	restlessness, dizziness, sore throat, bloody nose
Intranasal corticosteroids	hay fever and allergies	headache, sore throat, bloody nose
Antihistamines	sneezing and runny nose	drowsiness

Pricing guide

$ = under $5
$$ = $5–$10
$$$ = over $10

Best OTC sinus decongestant for allergies

Benadryl Allergy Plus Congestion Ultratabs

Price: $$
Type: oral tablet
Drowsy effect: yes

What we liked: These tablets contain diphenhydramine, an antihistamine ingredient that may reduce allergy symptoms, and phenylephrine, which may reduce sinus congestion. You can take one of these tablets every 4 hours throughout the day, and reviewers note that they take effect relatively quickly.

What to know: These tablets aren’t intended to clear the flu or a cold, so it’s important to only take them if your sinus congestion occurs due to allergies. Also, be aware that diphenhydramine can make you feel quite sleepy, so avoid this medication on days when you need to be alert.

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Best OTC sinus decongestant for a headache

Advil Sinus Congestion and Pain

Price: $$$
Type: oral tablet
Drowsy effect: no

What we liked: These coated tablets contain the decongestant ingredient phenylephrine along with the pain reliever ibuprofen. You can take a tablet up to every 4 hours. The combination of nasal swelling relief, along with the pain relief medication, can quickly relieve many sinus-related headaches. Many reviewers who have frequent sinus headaches swear by this product as being better than even some prescription medications.

What to know: Make sure to keep track of the amount of ibuprofen you’re taking if you’re taking this product. Do not take additional pain relievers, like acetaminophen or aspirin, with this product unless a doctor instructs you to. It’s easy to end up taking a dose that’s higher than recommended of analgesics when you’re mixing medications.

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Best OTC sinus decongestant nasal spray

Afrin No Drip Severe Congestion

Price: $$$ (twin pack)
Type: nasal spray
Drowsy effect: no

What we liked: Nasal sprays like Afrin can shrink swollen nasal passages by directly applying an active ingredient to your sinuses. The advantage of this can be that sprays tend to work more quickly than tablets or liquid decongestants. Afrin’s spray contains oxymetazoline hydrochloride and menthol, which relax and refresh your nasal passages pretty much right away, according to reviewers.

What to know: Afrin should only be used temporarily to relieve sinus congestion. Rebound stuffiness can occur in as little as 3 days. Using nasal sprays for a long duration can lead to side effects.

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Best OTC sinus decongestant for kids

Little Remedies Decongestant Nose Drops

Price: $$
Type: nose drops
Drowsy effect: no

What we liked: These dye-free drops contain phenylephrine in a dosage that’s safe for kids 2 and up. The dropper-dose formula can be applied 2 to 3 drops at a time directly to nasal passages, which makes for fast relief. (No waiting for tablets to kick in at bedtime). This decongestant can work for symptoms of a cold or flu, or it can be used to help manage congestion caused by allergies.

What to know: It can be difficult to get little ones to sit still and have the drops applied into their noses. You may have better luck putting the formula in a spray-mist bottle or another mist-based bottle to help apply it into their noses.

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Best OTC decongestant day/night duo

Sudafed PE Day and Night Sinus Pressure Tablets

Price: $$
Type: oral tablet
Drowsy effect: daytime formula is nondrowsy; nighttime formula has drowsy side effects

What we liked: These tablets contain phenylephrine for sinus congestion relief during the daytime and an additional antihistamine ingredient for nighttime use. These ingredients can treat environmental allergies and congestion caused by the common cold. There are 12 tablets meant for daytime use and 8 that you can take at night, which means you can take a few extra tablets during the day if you need to, but stick to one right before bedtime once you’re ready to sleep.

What to know: There’s no pain relief ingredient included in either the day or nighttime formulas of these tablets. That means that if you have a headache and treating your sinus pressure doesn’t give you relief, you might still find yourself reaching for acetaminophen at the end of the day.

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Best OTC sinus decongestant on a budget

Cabinet Nasal Decongestant Tablets

Price: $$$
Type: oral tablet
Drowsy effect: no

What we liked: This mega-size container of 225 tablets is a great solution if multiple people in your family tend to get allergies or sinus headaches. The no-frills phenylephrine formula is comparable to the dosage you’d find in a name brand but at a fraction of the cost. The formula doesn’t contain anything that will make you sleepy, and you can take a tablet every 4 hours on days when symptoms affect you.

What to know: Some customers complained that the bottle is too large to fit in their medicine cabinet, which seems like a small complaint for a product if you’ll be using it often. This particular tablet only targets sinus congestion, so it will not relieve symptoms like fever or a cough.

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Best OTC decongestant for bedtime

Mucinex Nightshift Cold and Flu Liquid

Price: $$$
Type: liquid
Drowsy effect: yes

What we liked: This liquid formula contains a pain reliever, a cough suppressant, and an antihistamine ingredient that can work together to give you a good night’s sleep when you’re sick. It does not contain any decongestant, however, so keep that in mind when taking this treatment. It’s great for bedtime because it calms coughing fits that may be keeping you up at night. Although it does not contain a decongestant, the antihistamine ingredient may also reduce nasal congestion caused by seasonal allergies.

What to know: Unlike the other decongestants on this list, this product doesn’t contain anything that loosens mucus. Some reviewers note that they really dislike the taste of this medication.

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Decongestant	Best for	Price	Type	Drowsy effect?
Benadryl Allergy Plus Congestion Ultratabs	allergies	$$	oral tablet	yes
Advil Sinus Congestion and Pain	headache	$$$	oral tablet	no
Afrin No Drip Severe Congestion	nasal spray	$$$ (twin pack)	nasal spray	no
Little Remedies Decongestant Nose Drops	kids	$$	nose drops	no
Sudafed PE Day and Night Sinus Pressure Tablets	day and night use	$$	oral tablet	daytime formula: no, nighttime formula: yes
Cabinet Nasal Decongestant Tablets	large supply on a budget	$$$	oral tablet	no
Mucinex Nightshift Cold and Flu Liquid	bedtime	$$$	liquid	yes

When you’re figuring out which decongestant to buy, you’ll need to determine what’s causing your congestion.

If it’s allergies, you’ll probably want a product that contains an antihistamine ingredient like diphenhydramine. Antihistamines target your body’s immune response to allergens like pollen. Antihistamines usually make the person taking them a bit drowsy, so keep in mind, taking them at any time other than bedtime may have you needing a nap.

If you have cold or flu symptoms, you may be looking for a product that includes phenylephrine or pseudoephedrine. These ingredients work by shrinking your blood vessels, which can help you breathe more easily and reduce the symptoms of a sinus headache or a stuffy nose.

However, both of these ingredients can cause you to feel restless and can make it difficult to fall asleep. These types of drugs can also make you nauseous. Generally, phenylephrine may have fewer serious side effects than pseudoephedrine. Always consult a doctor before taking these meds if you are pregnant or breastfeeding.

Some OTC sinus decongestant formulas include both antihistamines and decongestant ingredients, and some add pain relief ingredients such as ibuprofen to their formula. It’s best to treat for symptoms that you have, not for additional symptoms that you don’t have.

If you’re already taking OTC pain relief medication for, say, a sinus headache, you don’t want to add additional pain relief meds into the mix if you don’t need to.

It’s difficult to keep track of dosage when you’re mixing medications that have overlapping active ingredients, and too much of any pain reliever can lead to complications like stomach issues, rebound headaches, and kidney damage.

Treating your congestion with OTC products doesn’t always provide relief. Get professional medical care if you experience any of the following:

persistent congestion that lasts for a week or more
a high fever that lasts for more than 48 hours
chest pain of any sort
difficulty breathing

There are also home remedies that you can use to relieve discomfort and clear your congestion. Natural decongestion remedies include:

sleeping with a humidifier in your room
diffusing essential oils
using saline sprays
taking steamy showers
using a neti pot

When should I use a nasal decongestant?

If you have mild congestion caused by cold, flu, or seasonal allergies, you may want to consider an OTC nasal decongestant. This can help clear up your nasal passages and help you breathe more easily.

You don’t have to take a decongestant as part of your at-home treatment routine. Once your infection clears away or your allergies aren’t triggered, the congestion will clear up on its own.

Can or should I take a sinus decongestant for a sinus infection?

You can take certain decongestants for a sinus infection.

Decongestants that contain only pseudoephedrine or phenylephrine are more typically recommended for a sinus infection. Decongestants with additional ingredients like antihistamines may suppress your body’s immune response and interfere with your body’s ability to clear the infection.

If you have a severe sinus infection or if you’re taking antibiotics, talk with your doctor about the best OTC medication choice for you.

Do sinus decongestants work for ear congestion?

Sinus decongestants can work to relieve pressure in the upper sinus cavities. If you have ear congestion, relieving this pressure can help manage your pain. But sinus decongestants can’t treat an underlying ear infection.

Is it safe to take sinus decongestants while pregnant?

It depends on the active ingredient. OTC pseudoephedrine and phenylephrine should only be taken during pregnancy under your doctor’s supervision. They should not be taken during the first trimester, only after, and even then, only with your doctor’s recommendation.

Talk with your doctor before taking drugs containing these ingredients if you are pregnant or plan to become pregnant. Research in animals has shown adverse effects on the fetus when the birthing parent takes these drugs. There haven’t been enough studies with humans to be certain how the drug might affect the fetus. These drugs should only be taken if the potential benefit justifies the potential risk.

Can you take sinus decongestants if you have high blood pressure?

Phenylephrine is not considered to be safe if you have high blood pressure. Sinus decongestants that contain pseudoephedrine may actually raise your blood pressure and counteract the blood pressure medication that you’re taking. If you have high blood pressure, speak with your doctor about which decongestant they recommend for you.

The best way to choose an OTC decongestant is to look at the active ingredients. A good decongestant should treat only the symptoms you have, and not any additional symptoms you don’t have.

OTC decongestants are not a solution for severe, long lasting sinus infections and chronic allergies. You may need to speak with your doctor about a long-term strategy if you find that OTC decongestants aren’t effectively managing your symptoms.

7 Best Nasal Decongestants You can Get Over the Counter

We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.

Healthline only shows you brands and products that we stand behind.

Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:

Evaluate ingredients and composition: Do they have the potential to cause harm?
Fact-check all health claims: Do they align with the current body of scientific evidence?
Assess the brand: Does it operate with integrity and adhere to industry best practices?

We do the research so you can find trusted products for your health and wellness.

Decongestant type	Best for	Possible side effects
Phenylephrine decongestant	sinus congestion caused by cold and flu	restlessness, dizziness, anxiety
Pseudoephedrine decongestant	sinus congestion caused by cold and flu	restlessness, dizziness, anxiety, nausea, upset stomach
Intranasal decongestants	sinus congestion caused by cold and flu	restlessness, dizziness, sore throat, bloody nose
Intranasal corticosteroids	hay fever and allergies	headache, sore throat, bloody nose
Antihistamines	sneezing and runny nose	drowsiness