How does caffeine enhance pain relief in Excedrin. What is the recommended dosage of Excedrin Migraine. How quickly can Excedrin provide headache relief. What are the potential side effects of caffeine in pain medications. How effective is Excedrin Migraine compared to placebo in clinical studies.

The Science Behind Caffeine’s Pain-Relieving Properties

Caffeine, a natural stimulant found in coffee beans, tea leaves, and cocoa nuts, is consumed daily by approximately 85% of Americans. But did you know that this popular “pick-me-up” also plays a crucial role in pain relief? Let’s explore how caffeine contributes to alleviating headache pain when combined with other active ingredients in medications like Excedrin.

How Does Caffeine Work in Pain Relief?

Caffeine’s pain-relieving properties stem from its ability to:

• Block certain receptors in the body and brain
• Cause vasoconstriction, narrowing blood vessels and restricting blood flow
• Enhance the efficacy of analgesics
• Increase the body’s absorption of pain-relieving medications

These mechanisms work together to provide faster and more effective relief from headache pain.

The Synergistic Effect of Caffeine in Pain Medications

While caffeine alone cannot completely resolve headaches, its combination with other active ingredients in pain relievers creates a powerful synergistic effect. Studies have shown that when caffeine is combined with acetaminophen and aspirin – the three key ingredients in Excedrin – it becomes more effective in relieving headache pain.

Understanding Excedrin’s Formulation

Excedrin offers several products containing caffeine, including Excedrin Extra Strength, Excedrin Migraine, and Excedrin Tension Headache. These medications provide quick relief due to their unique combination of pain relievers and caffeine.

What’s in Excedrin Migraine?

Each tablet of Excedrin Migraine contains:

• 65 mg of caffeine
• 250 mg of acetaminophen
• 250 mg of aspirin

A regular adult dose of two tablets provides 130 mg of caffeine, roughly equivalent to an 8-12 ounce cup of coffee.

Proper Usage and Dosage of Excedrin Migraine

To ensure safe and effective use of Excedrin Migraine, follow these guidelines:

1. Take 2 tablets with a glass of water for adults
2. Do not exceed two tablets in a 24-hour period unless directed by a doctor
3. If symptoms worsen or persist, consult your healthcare provider
4. Individuals under 18 should consult a doctor before use

How quickly can Excedrin Migraine work? In some people, relief can be experienced in as little as 30 minutes. For others, Excedrin Extra Strength may provide relief in just 15 minutes.

The Role of Caffeine in Migraine Treatment

Caffeine’s relationship with migraines is complex. For some patients, it can trigger a migraine headache. However, when combined with acetaminophen and aspirin, it has been shown to be beneficial in migraine treatment.

Balancing Caffeine Intake

While using Excedrin Migraine, it’s important to be mindful of your overall caffeine consumption. Limit your intake of caffeine-containing medications, foods, or beverages to avoid potential side effects such as nervousness, irritability, sleeplessness, and rapid heartbeat.

Clinical Evidence: Excedrin Migraine’s Effectiveness

How well does Excedrin Migraine work compared to a placebo? Let’s look at the clinical evidence:

Study Overview

Three double-blind, randomized, and placebo-controlled studies involving 1,220 participants assessed the effectiveness of the OTC combination of acetaminophen, aspirin, and caffeine in alleviating moderate-to-severe migraine headache pain.

Key Findings

The studies revealed:

• Significantly greater reduction in migraine pain intensity 1 to 6 hours after taking the medication compared to placebo
• Over 59% of participants experienced reduced pain (mild or none) 2 hours after taking the medication, compared to about 33% in the placebo group
• Continued pain relief was observed up to 6 hours after dosing

Potential Side Effects and Precautions

While Excedrin Migraine can be an effective treatment for many, it’s essential to be aware of potential side effects and take necessary precautions:

Caffeine-Related Side Effects

Excessive caffeine intake can lead to:

• Nervousness
• Irritability
• Sleeplessness
• Rapid heartbeat

To minimize these risks, be mindful of your total caffeine intake from all sources when using Excedrin Migraine.

Other Considerations

• Consult your healthcare provider before using Excedrin Migraine if you have a history of stomach ulcers, liver disease, or are taking blood thinners
• Avoid use during pregnancy or while breastfeeding without medical advice
• Do not use with other products containing acetaminophen to prevent liver damage

Alternatives to Excedrin Migraine

While Excedrin Migraine is effective for many, it may not be suitable for everyone. What are some alternatives for migraine relief?

Other Over-the-Counter Options

• Ibuprofen-based medications (e.g., Advil Migraine, Motrin Migraine Pain)
• Naproxen sodium (e.g., Aleve)
• Combination products without caffeine

Prescription Medications

For those with frequent or severe migraines, prescription options may include:

• Triptans
• CGRP antagonists
• Ergotamines
• Preventive medications

Always consult with a healthcare provider to determine the best treatment plan for your specific needs.

Lifestyle Modifications for Migraine Management

In addition to medication, certain lifestyle changes can help manage migraines:

Trigger Identification and Avoidance

Common migraine triggers include:

• Certain foods and drinks (e.g., aged cheeses, alcohol, artificial sweeteners)
• Stress
• Changes in sleep patterns
• Hormonal fluctuations
• Environmental factors (e.g., bright lights, strong odors)

Keeping a migraine diary can help identify personal triggers.

Stress Management Techniques

Incorporating stress-reducing activities into your routine can help prevent migraines:

• Regular exercise
• Meditation or mindfulness practices
• Yoga
• Deep breathing exercises
• Adequate sleep

Dietary Considerations

Maintaining a healthy diet and staying hydrated can contribute to migraine prevention:

• Eat regular, balanced meals
• Stay hydrated throughout the day
• Limit caffeine intake
• Avoid skipping meals

When to Seek Medical Attention

While Excedrin Migraine can effectively manage many headaches, certain situations warrant medical attention. When should you consult a healthcare provider?

Red Flags for Immediate Medical Care

Seek immediate medical attention if you experience:

• Sudden, severe headache often described as “the worst headache of your life”
• Headache accompanied by fever, stiff neck, confusion, or neurological symptoms
• New onset of headaches after age 50
• Headaches that worsen with coughing, exertion, or sudden movement
• Persistent headaches following a head injury

Signs of Medication Overuse

Frequent use of pain relievers, including Excedrin Migraine, can lead to medication overuse headaches. Consult your doctor if:

• You’re using pain relievers more than 10-15 days per month
• Your headaches are becoming more frequent or severe
• You find yourself needing higher doses of medication for relief

Understanding the role of caffeine in pain relief and the proper use of medications like Excedrin Migraine can significantly improve your ability to manage headaches effectively. Remember to always use these medications as directed and consult with a healthcare provider for personalized advice on headache management strategies.

Excedrin® and Caffeine: How Caffeine Can Help

If you suffer from frequent headaches, then you understand how important it is to get quick relief. What you may not know is that some medications contain ingredients that help alleviate headache pain. One surprising ingredient that makes a big difference? Caffeine.¹

Where Caffeine Comes From

Caffeine is found naturally in many plant sources, including coffee beans, tea leaves, and cocoa nuts.¹ Widely used as a popular “pick-me-up,” the stimulant is consumed by approximately 85 percent of people in the US every day.² It takes between 30 minutes and two hours to reach its full impact, and caffeine’s effects can be felt for an average of five hours.^3, 4

How Caffeine Affects Your Body

Beyond boosting your energy, caffeine has important applications for pain relief as well. Research shows that caffeine could reduce pain by blocking certain receptors in the body and brain. ⁵

Before a headache or migraine, the body’s blood vessels tend to enlarge.⁶ Caffeine causes vasoconstriction, which narrows the body’s blood vessels and restricts blood flow, aiding in pain relief.^5, 6 Additionally, caffeine can make analgesics work more efficiently and increase your body’s absorption of pain-relieving medications like Excedrin^®.^1, 7

Why Some Forms Work Better

While caffeine does have pain-relieving effects, studies have found that caffeine alone cannot completely resolve headaches. However, when combined with other active ingredients in pain relievers, caffeine can provide an additional boost.¹

Unfortunately, it’s not quite as simple as drinking coffee while taking a pain reliever. A standard cup of coffee may have as much as 134 mg of caffeine, but the concentration of the stimulant makes a big difference in how effective it is for headache relief. ^8, 9 Studies show that when caffeine is combined with acetaminophen and aspirin—the three ingredients of Excedrin^® —it is more effective in relieving headache pain.^8,9

Pain Relievers That Contain Caffeine

Three Excedrin products—Excedrin^® Extra Strength, Excedrin^® Migraine and Excedrin^® Tension Headache —contain caffeine. These medications provide quick relief due to a combination of pain relievers and caffeine. Excedrin^® Extra Strength may even provide relief in 15 minutes for some people.

Remember to discuss all medications you take for headache or migraine with your doctor, even when taking an over-the-counter product. Products should only be used as directed.

How much caffeine is in Excedrin Migraine?

Each tablet of Excedrin Migraine contains 65 milligrams (mg) of caffeine, 250 mg of acetaminophen, and 250 mg of aspirin. A regular adult dose (2 tablets) contains 130 mg of caffeine, roughly equal to an 8-12 ounce cup of coffee.

How to take Excedrin Migraine

• The regular dosage for adults is 2 tablets with a glass of water.
• Do not take more than two tablets in any 24-hour period, unless directed by a doctor.
• If symptoms worsen or persist, contact your doctor. If you are under 18 years of age, ask a doctor before use.

Excedrin Migraine is an over-the-counter (OTC) medicine approved by the FDA for the relief of migraine pain. In clinical studies, patients with moderate to severe migraines experienced relief with one dose. It can work as quickly as 30 minutes in some people.

The recommended dose of Excedrin Migraine (2 tablets) contains 130 mg of caffeine, which is roughly as much caffeine as found in an 8 ounce cup of coffee. Limit your use of caffeine-containing medications, foods, or beverages while using Excedrin Migraine. Excessive caffeine can cause nervousness, irritability, sleeplessness, and rapid heart beat.

Caffeine has been shown to increase the effects of pain relievers like aspirin and acetaminophen and help to make these medicines more effective in migraine. For some patients, caffeine can trigger a migraine headache, but it has also been shown to be helpful when combined with acetaminophen and aspirin.

How well does Excedrin Migraine work?

In three double-blind, randomized, and placebo-controlled studies with 1220 participants, researchers assessed the effectiveness of the OTC combination of acetaminophen, aspirin, and caffeine in alleviating moderate-to-severe migraine headache pain.

Participants took 2 tablets of the OTC acetaminophen, aspirin, and caffeine or a placebo as a one-time dose for treatment of one migraine attack.

Results showed a significantly greater reduction in migraine pain intensity 1 to 6 hours after the OTC acetaminophen, aspirin, and caffeine dose than placebo in all three studies.

• Pain was reduced to mild or none 2 hours after the dose in over 59% of those taking acetaminophen, aspirin, and caffeine compared to about 33% of placebo-treated patients.
• At 6 hours after the dose, 79% receiving acetaminophen, aspirin, and caffeine had pain reduced to mild or none vs. 52% in the placebo group, and 51% of the drug-treated patients were pain free (with 24% pain-free in the placebo group).
• Symptoms of nausea, photophobia (light sensitivity with pain), phonophobia (sound sensitivity with pain) and functional disability were improved 2 to 6 hours after treatment.

Excedrin Migraine is associated with warnings and side effects, some of which may be severe.

These include:

• Reye’s Syndrome
• risk of allergy
• liver toxicity
• stomach bleeding
• headache rebound due to medication overuse
• caffeine overuse

Review side effects and warnings here (in more detail)

Bottom Line

• Each tablet of Excedrin Migraine contains 65 milligrams (mg) of caffeine, 250 mg of acetaminophen, and 250 mg of aspirin.
• The dosage for adults is 2 tablets with a glass of water. Do not take more than two tablets or geltabs in any 24-hour period, unless directed by a doctor.
• People under 18 years of age should ask a doctor before use.

This is not all the information you need to know about Excedrin Migraine for safe and effective use. Review the full Excedrin Migraine information here, and discuss this information and any questions you have with your doctor or other health care provider.

Excedrin & Caffeine | Livestrong.com

Excedrin PM does not contain caffeine.

Image Credit: bookzaa/iStock/Getty Images

Excedrin is an over-the-counter medication marketed by the pharmaceutical company Navartis as a pain reliever. Although originally formulated to treat headache pain, Excedrin now includes a family of medications to target other types of pain. Some formulations of Excedrin contain caffeine because caffeine helps to relieve headache pain.

Why Add Caffeine?

Many over-the-counter and prescription medications contain caffeine. Caffeine functions as a stimulant so it can counteract the effect of medications that cause drowsiness. In pain relievers, caffeine boosts the effects of the analgesic agent. Adding caffeine to medications that contain aspirin or acetaminophen makes them 40 percent more effective, according to the Cleveland Clinic. Caffeine also increases the absorption of the analgesic, which not only helps it work better but also helps it work faster.

Formulations with Caffeine

Excedrin now includes a group of medications, each marketed to treat a specific type of headache or pain. Many of the Excedrin formulations contain caffeine, but not all of them do. Excedrin Extra Strength contains a combination of 250 mg of acetaminophen, 250 mg of aspirin and 65 mg of caffeine. This represents the original Excedrin created to treat headache pain. Excedrin also makes Excedrin Migraine to target the pain caused by migraine headaches. Excedrin Migraine contains 250 mg of acetaminophen, 250 mg of aspirin and 65 mg of therapeutically active caffeine. Excedrin Menstrual Complete contains the same active ingredients as Excedrin Extra Strength, but the listed purpose of the caffeine is as a diuretic to help reduce bloating as well as aiding the pain relief medications. Excedrin Tension Headache formula, also known as the aspirin-free formula, contains 250 mg of acetaminophen and 65 mg of caffeine.

Caffeine-Free Formulations

Some of the Excedrin products are marketed for other uses and do not contain caffeine. Excedrin Sinus contains 325 mg of acetaminophen combined with a nasal decongestant to treat headaches caused by sinus pressure. Excedrin Back and Body helps relieve minor aches and pains with 250 mg of acetaminophen and 250 mg of buffered aspirin. Excedrin PM helps to relieve pain while also helping you fall asleep. Since caffeine is a stimulant, Excedrin PM does not contain caffeine.

Caution

When taking an Excedrin product that contains caffeine, carefully follow the dosing instructions provided. You should also limit your consumption of caffeine-containing foods and beverages to avoid possible side effects. Too much caffeine can cause irritability, nervousness and sleeplessness. In addition, The American Headache Society recommends that you take caffeine-containing pain medications no more than twice a week. Taking Excedrin more often can lead to the onset of rebound headaches, also known as medication overuse headaches. The only treatment for this type of headache is to stop taking all medications and decrease your intake of caffeine; you should do this under the supervision of your health care provider.

Recommended Doses of Acetaminophen, Aspirin, Caffeine and Excedrin® • National Headache Foundation

15 Dec Reader’s Mail: Recommended Doses of Acetaminophen, Aspirin, Caffeine and Excedrin®

Posted at 21:06h
in News to Know
by headache

Q. Excedrin Extra Strength gelcaps each contain 250 mg. of acetaminophen, 250 mg. of aspirin and 65 mg. of caffeine. Excedrin Migraine caplets contain exactly the same amounts of each ingredient. However, the first product allows the use of eight gelcaps in 24 hours, whereas the latter only allows the use of two caplets in 24 hours. Why the difference in the allowable use of two pills of apparently the same medication?

A. The Excedrin Migraine recommendation is lower to avoid developing medication overuse headache. An advisory committee of the Food and Drug Administration also made the following recommendations for the use of acetaminophen in order to reduce the incidence of liver injury: 1) the single adult acetaminophen dose should not exceed 650 mg. and 2) the maximum total daily recommended dose should be no more than 2,600 mg/day.

In regards to aspirin and caffeine: 1) the maximum daily dose of aspirin should not be more than 4,000 mg/day, an amount that is actually inappropriately high for headache treatment, and 2) caffeine ingestion should be limited to no more than 1-2 8-oz cups per day in migraineurs in order to minimize the risk of developing withdrawal headaches or medication-overuse headaches.

If you are using moderate to large quantities of acetaminophen or aspirin, it should only be under the supervision of a healthcare professional. Additionally, escalating frequency of use, or the use of moderate to high doses of over-the-counter (OTC) medications, should prompt you to seek your doctor’s advice. Other options may be available for you.

Finally, all drugs, including OTC medications, have potentially serious side effects if overused. In this case, you should be aware that gastrointestinal discomfort and even bleeding can occur with aspirin use and liver toxicity can occur with the use of acetaminophen when taken at high doses.

Barbara Lee Peterlin, M.D.
Drexel University of Medicine
Philadelphia, PA

Re: Why does Excedrin Migraine provide an energy b…

Hello Dr. Cooke and Dr. Freeman,

Thank you so much for taking an interest in and replying to my inquiry about finding an alternate to Excedrin Migraine.  I’ve tried different OTC remedies and combinations on my own. Aspirin, Tylenol and Advil by themselves or with caffeine don’t work. No-Doz doesn’t do the same thing as Excedrine Migraine. Coffee, cola and chocolate are migraine triggers and lead me to Excederin Migraine (generic version with same ingredients also works.) The combination of 500 mg acetaminophen, 250 mg of aspirin, and 65 mg of caffeine relieves migraines for me and many other people, it’s a very popular OTC remedy. I discovered that this combination of chemicals is wonderful for temporary relief of chronic fatigue and Crohn’s related symptoms. I’m aware of the side effects and want to find a safer OTC or natural remedy and perhaps, discover something that works for other people with the same condition.

Here’s a link to the article that lead me to ACS:

How Does Acetaminophen Work? Researchers Still Aren’t Sure

A clearer picture might pave the way for new painkillers

By Carmen Drahl

https://cen. acs.org/articles/92/i29/Does-Acetaminophen-Work-Researchers-Still.html

Also, I searched online for people who share my experience:

https://thumpertalk.com/forums/topic/692932-excedrin-migraine-energy-booster/

“…started taking excedrin migraine and it totally stops my migraines. One of the side effects for me is gives me a huge energy boost and a feeling of euphoria. I mean, I feel like I’m on top of the world after I take this stuff.

I like to mountain bike at lunch time at work. Today I was having a headache so I popped a couple of excedrin migraine and went for a ride. I had so much energy today it was unbelievable. After every hill climb I recovered much faster and we ready for another…”

This is a very important issue for me and I appreciate that you’ve taken time to consider it.

Ruth Katz

acetaminophen, aspirin, and caffeine | Michigan Medicine

What is the most important information I should know about this medicine?

Do not give this medicine to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye’s syndrome, a serious and sometimes fatal condition in children.

Do not take more than the recommended dose. An acetaminophen overdose can damage your liver or cause death.

Call your doctor at once if you have: nausea, upper stomach pain, loss of appetite, dark urine, yellowing of your skin or eyes, clay-colored stools, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds.

In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

What is acetaminophen, aspirin, and caffeine?

Acetaminophen is a pain reliever and a fever reducer. Aspirin is a salicylate (sa-LIS-il-ATE). Caffeine is a central nervous system stimulant.

Acetaminophen, aspirin, and caffeine is a combination medicine used to treat pain caused by tension headaches, migraine headaches, muscle aches, menstrual cramps, arthritis, toothaches, the common cold, or nasal congestion.

Do not use aspirin for heart or blood vessel conditions unless your doctor tells you to.

Acetaminophen, aspirin, and caffeine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking this medicine?

Do not give this medicine to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye’s syndrome, a serious and sometimes fatal condition in children.

You should not use this medicine if you are allergic to acetaminophen (Tylenol), aspirin, caffeine, or any NSAIDs (diclofenac, ibuprofen, indomethacin, meloxicam, naproxen, Advil, Aleve, Motrin, and others).

Aspirin may cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are taking this medicine.

Ask a doctor or pharmacist if this medicine is safe to use if you have ever had:

• liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day;
• asthma or seasonal allergies;
• fever with a stiff neck;
• stomach ulcer, stomach or intestinal bleeding, ulcerative colitis;
• bleeding problems;
• kidney disease; or
• if you use medicine to treat glaucoma or prevent blood clots.

If you take acetaminophen, aspirin, and caffeine to treat headache pain, seek medical attention if you have:

• a headache so bad you have to lie down;
• a headache that causes vomiting;
• what feels like the worst headache you’ve ever had;
• a headache that seems different from your usual headaches;
• a headache every day;
• a headache after coughing, bending, exercising, or head injury;
• if you have never had migraines diagnosed by a doctor; or
• if you are having your first headache after age 50.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery. Ask a doctor before using this medicine if you are pregnant.

Do not give this medicine to anyone younger than 18 years old without medical advice.

How should I take this medicine?

Use exactly as directed on the label, or as prescribed by your doctor. Never use more than the recommended dose. An overdose of acetaminophen can damage your liver or cause death.

Take with food or milk if the medicine upsets your stomach.

Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever lasting longer than 3 days, or any swelling or pain lasting longer than 10 days.

Overuse of migraine headache medicine (more than 10 days per month) can make headaches worse. Tell your doctor if this medicine seems to stop working as well.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using acetaminophen, aspirin, and caffeine.

If you need surgery, dental work, or a medical procedure, you may need to stop taking this medicine for a short time.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since acetaminophen, aspirin, and caffeine is used when needed, you may not be on a dosing schedule. Skip any missed dose if it’s almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can damage your liver or cause death.

Early signs of acetaminophen overdose include loss of appetite, nausea, vomiting, sweating, or weakness. Later symptoms may include upper stomach pain, dark urine, and yellowing of your skin or eyes.

Overdose symptoms may also include ringing in your ears, headache, diarrhea, hallucinations, fast or slow heart rate, or seizure (convulsions).

What should I avoid while taking this medicine?

Avoid drinking alcohol. It may increase your risk of liver damage or stomach bleeding.

Ask a doctor or pharmacist before using other medicines for pain, fever, swelling, or cold/flu symptoms. They may contain ingredients similar to acetaminophen or aspirin (such as ibuprofen, ketoprofen, or naproxen).

Avoid coffee, tea, cola, energy drinks or other sources of caffeine while taking this medication. They can add to the side effects of the caffeine in the medication.

What are the possible side effects of this medicine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen.

Stop using this medicine and call your doctor at once if you have:

• severe anxiety, agitation, confusion, panic;
• easy bruising or bleeding;
• a light-headed feeling, like you might pass out;
• dehydration symptoms –feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
• symptoms of stomach bleeding –bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
• high potassium –nausea, weakness, tingly feeling, chest pain, irregular heartbeats, loss of movement; or
• liver problems –nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

• upset stomach, heartburn;
• depressed mood, feeling anxious or restless; or
• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect acetaminophen, aspirin, and caffeine?

Other drugs may affect acetaminophen, aspirin, and caffeine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Where can I get more information?

Your pharmacist can provide more information about acetaminophen, aspirin, and caffeine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. (‘Multum’) is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum’s drug information does not endorse drugs, diagnose patients or recommend therapy. Multum’s drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2021 Cerner Multum, Inc. Version: 8.02. Revision date: 7/29/2020.

Caffeine and Headaches | Speaking of Women’s Health

Caffeine can be a double-edged sword for those with a headache: it can serve as a treatment or in some cases can cause withdrawal or a phenomenon known as “rebound” headache. The important thing to remember is that with education and moderation, caffeine can be one of the most effective treatments for headache.

Caffeine as a Headache Treatment

Caffeine is a common ingredient in many prescription and over-the-counter headache medications. Because analgesics work more quickly and more efficiently with caffeine, patients are able to take less medication. Caffeine additives make pain relievers 40 percent more effective. Caffeine also helps the body absorb medications more quickly, allowing the patient to feel relief sooner. By adding caffeine and, in turn, taking less medication, the patient reduces the risk for potential side effects and reduces the risk of habitual or addictive usage.

Common Over-the-Counter Drugs Containing Caffeine

Drug Name	Caffeine Content
Anacin Maximum Strength	32 mg
Anacin Tablets and Caplets	32 mg
Aspirin-Free Excedrin Caplets	65 mg
Excedrin Extra Strength Caplets and Tablets	65 mg
Excedrin Migraine	65 mg
Goody’s Extra Strength Tablets	16. 25 mg
Goody’s Headache Powder	32.50 mg
Midol Menstrual Maximum Strength Caplets	60 mg
NoDoz Maximum Strength	200 mg
Pain Reliever Plus Tablets	65 mg
Vanquish Caplets	33 mg
Vivarin	200 mg

Common Prescription Drugs Containing Caffeine

Note: The drugs listed are some of the more common drugs containing caffeine; all drugs containing caffeine are not included. Always check the labels of over-the-counter drugs for the caffeine content. Or, ask your health care provider or pharmacist about the caffeine content of your medications.

Food as Caffeine Sources

• Chocolate milk, chocolate milkshakes, hot chocolate and chocolate drinks.
• Cola and other sodas. Caffeine-free and decaffeinated beverages also contain small amounts of caffeine.
• Coffee.
• Tea.
• Chocolate products, including candy, brownies, ice cream, and cake.

Caffeine and Withdrawal

Caffeine withdrawal from normal caffeine usage is rare. However, with excess use, over 500 mg. daily (approximately 5 cups of coffee) over a long period of time, sudden cessation could cause symptoms of withdrawal. Patients can avoid caffeine withdrawal by limiting their daily consumption, being educated about sources of caffeine and by gradually decreasing the consumption rather than ending use abruptly.

Caffeine and Rebound Headaches

Rebound headache is a condition that develops from the overuse or misuse of any headache medication, including caffeine-containing medication. While caffeine-containing medications can be beneficial, these medications, combined with consuming caffeine (coffee, tea, soft drinks or chocolate) from other sources, makes you more vulnerable to a rebound headache.

Relief from rebound headache can only be accomplished by completely quitting all medication – however, this should only be done under the supervision of a physician.

90,000 Tablets for headache

Contents of the article

Types

Conventionally, all pills for headaches are divided into three types: simple analgesics (paracytamol, ibuprofen), triad (a combination of three main components: ASA + phenacetin + caffeine), five (represented by the formula: 2 analgesics + codeine + hypnotic phenobarbital + caffeine).

Depending on the manufacturing formula, all drugs for headache can be classified into:

• Simple analgesics. The composition of such drugs includes only one active ingredient – analgin. Also, the basis of the drug can be paracetamol, acetylsalicylic acid or ibuprofen. These drugs are sold without a prescription. The group of paracytamols includes: Paracetamol, Efferalgan, Panadol, Calpol, Strimol, Flutabs, Daleron. To ibuprofen: Ibuprofen, Brufen, Nurofen, Solpaflex, MIG, Faspik, Advil, Bonifen, Pedea, Deblok, Ibalgin.

• Troika. The drugs in this group contain caffeine and two analgesics (usually phenacetin and ASA).The main thing here is caffeine, which can enhance and prolong the analgesic effect. Interestingly, this group also includes “twos” – those that contain only one analgesic. Among the common drugs, “triad” are: Citramon P, Excedrin, Citrapar, Kofitsil-Plus, Aquacitramon, Citrapak. All of them are created according to a formula that combines caffeine, ASA and paracetamol, while drugs such as Kaffetin SK, Novalgin, Guvadal, Saridon, Flucomp Ekstratab are based on propiphenazone, caffeine and paracetamol.
• Pentacles are medicines based on the combination of 5 components: 2 analgesics, hypnotic phenobarbital, codeine and caffeine. Codeine has an analgesic effect, enhancing the effect. Sleeping pills and caffeine also have an enhancing effect. The most popular types of such drugs are Sedalgin-Neo, Pentalgin-ICN, Sedal-M.

What symptoms should you use

Headache can be of different nature. The most common type is migraine.A migraine is a severe, prolonged headache that can last 3-4 hours to several days. The head may ache on one or both sides, mainly localized in the frontal and temporal lobes. The pain is pulsating and may be accompanied by vomiting, nausea, and worse in bright light or noise.

Another type of pain is tension pain. It is formed due to a long stay of a person in one position, as well as in the course of emotional stress, can be caused by fatigue.Such pains are not characterized by intensity, as a rule, they are dull and aching. There will be a feeling of tightness in the head. The duration of such discomfort is from 30 minutes to a couple of hours.

Another type of headache is vascular headache. It occurs with hypotension or hypertension. For the treatment of such an ailment, drugs should be used to increase (in case of hypotension) or lower (in case of hypertension) blood pressure. Such medications can only be taken after being prescribed by a doctor.Analgesics usually provide significant relief.

Therapeutic effect

There are several main drugs for headaches that have certain effects on the body. For example:

• Analgin – eliminates migraine, relieves spasms that were provoked by various inflammatory processes. Allowable daily intake: 1 tablet 2 or 3 times a day.
• Solpadein is one of the newest drugs based on paracytamol, caffeine and codeine phosphate.Not only relieves headaches, but also acts as an anti-inflammatory and antiviral medication.
• Tempalgin is an analog of analgin, which includes tempidone. Relieves not only headache, but also toothache. Apply 1 tablet no more than 3 times a day.
• Pentalgin – may contain anaglin, caffeine, amidopyrone. It helps to normalize sleep and is characterized by a sedative effect.
• Citramon is one of the most common drugs for this ailment.It contains caffeine, citric acid. The use is possible for 1-2 tablets 2-3 times a day.

Contraindications

Headache pills are contraindicated in case of all kinds of allergic reactions to the components they contain, with open or closed bleeding (except menstrual bleeding), in case of stomach ulcers, exacerbations of intestinal diseases, during pregnancy (only with permission doctor), with defects of the kidneys and liver, with diseases of the cardiovascular system.

CITRAMON P MEDISORB N30 TABLES

Other non-steroidal anti-inflammatory drugs: increased damaging effect on the mucous membrane of the gastrointestinal tract, increased risk of gastrointestinal bleeding. If necessary, simultaneous use is recommended to use gastroprotectors for the prevention of NSAID-induced ulcers of the gastrointestinal tract, therefore, simultaneous use is not recommended.

instructions for use, analogs, composition, indications

Overdose of acetylsalicylic acid

Symptoms of mild salicylate intoxication include dizziness, tinnitus / ringing in the ears, deafness, sweating, nausea and vomiting, headache, and confusion.Such symptoms can be controlled by dose reduction or drug withdrawal.

Symptoms of a severe overdose include hyperventilation, fever, anxiety, ketosis, respiratory alkalosis, and metabolic acidosis. As a result of inhibition of the activity of the central nervous system, a coma may occur. Cardiovascular collapse and respiratory failure can also occur.

In case of severe overdose, the patient should be hospitalized. If there is a suspicion that the patient has taken salicylates at a dose of more than 120 mg / kg of body weight in the last hour, he should be given oral repeated doses of activated charcoal and the plasma levels of salicylates should be monitored.

At plasma concentrations exceeding 500 μg / ml (in children under 5 years of age – 350 μg / ml), intravenous sodium bicarbonate should be used to effectively remove salicylates from blood plasma.

Hemodialysis or hemoperfusion are the methods of choice in cases where the concentration of salicylates in the blood plasma is more than 700 μg / ml in adults or less in children and elderly patients, as well as in the case of severe metabolic acidosis.

Paracetamol overdose

Overdose (> 10 g in general in adults or> 150 mg / kg body weight at a time) can provoke the development of cytolysis of liver cells, which can lead to complete and irreversible necrosis (liver failure, metabolic acidosis, renal failure) and, as a result, up to coma and possibly death. Acute tubular necrosis may develop less frequently.

Early signs of an overdose (very often nausea, vomiting, lack of appetite, pallor, lethargy and sweating) usually appear in the first 24 hours after taking the drug.

The first sign of liver damage may be abdominal pain, which does not always appear in the first 24-48 hours, and can be postponed for up to 4-6 days after taking the drug.

At high risk are patients receiving therapy with enzyme-inducing drugs such as carbamazepine, phenytoin, phenobarbital, rifampicin and St. John’s wort, or a history of alcohol dependence, or patients suffering from malnutrition.

If there is a suspicion that the patient has taken paracetamol at a dose of more than 150 mg / kg of body weight in the last hour, he should be given repeated doses of activated charcoal orally. However, if oral administration of antidotes (acetylcysteine ​​or methionine) is planned, it is recommended to remove the activated charcoal from the stomach so that it does not reduce the absorption of the antidote.

As soon as possible after poisoning, the patient should be given N-acetylcysteine ​​intravenously or orally.This remedy is most effective within the first 8:00 after an overdose. After this, the effectiveness of the antidote progressively decreases. However, it has been shown that the use of the antidote up to 24 hours after poisoning and later remains advisable.

Methionine is most effective within the first 10:00 am after paracetamol overdose. Liver damage occurs more often and has a higher severity in cases where methionine therapy was started later than 10:00 after paracetamol overdose.

Oral absorption of the antidote may decrease due to vomiting or taking activated charcoal.

Caffeine overdose

Common symptoms include anxiety, nervousness, restlessness, insomnia, agitation, muscle twitching, confusion, and seizures. Hyperglycemia can also occur after taking high doses of caffeine. Cardiac symptoms include tachycardia and cardiac arrhythmias. Control overdose symptoms by dose reduction or caffeine withdrawal.

Excedrin and Alcohol * Mixing Alcohol and Excedrin

Excedrin and Alcohol

Excedrin and Alcohol

Aspirin / Paracetamol (acetaminophen) / Caffeine Combined medicine for the treatment of pain, especially headache and migraine It is sold in the US under the trade names Goody’s Powder and Excedrin, although not all products sold under the Excedrin brand contain this combination. It is marketed as Anadin Extra in the UK.

Source

What happens if you mix Excedrin and alcohol

Side effects from mixing Excedrin and alcohol may include:

• Dizziness
• Slowness
• Drowsiness
• Shortness of breath
• Itching
• Respiratory depression
• Cardiac arrest
• Coma
• Seizures
• Death

Interestingly, it is impossible to say what effect Excedrin and alcohol will have on a person due to their own unique genetic makeup and tolerance.It is never recommended to mix Excedrin and alcohol due to the potential for mild, moderate, and severe side effects.

Alcohol and Excedrin

Alcohol and Excedrin have different effects depending on the dose: many people feel agitated and empowered by low doses of alcohol and Excedrin, and even mixing small amounts of Excedrin and alcohol is not recommended.

Mixing alcohol and excedrin

The primary effect of alcohol is influenced by an increase in the concentration of the inhibitory neurotransmitter GABA, which is found in the spinal cord and brain stem, as well as a decrease in its effect on neural transmitters, which are excitatory.When alcohol is combined with Excedrin, this primary effect is enhanced, increasing the stress on the body with unpredictable results.

Alcohol and Excedrin affect dopamine levels in the brain, causing both mental and physical distress. Large amounts of Excedrin and alcohol have more pronounced adverse effects, but the main medical recommendation is that smaller amounts can be just as harmful, and there is no way to know exactly how Excedrin and alcohol will affect a person before they take them.

Simultaneous use of Excedrin and alcohol

People who take Excedrin and alcohol together will experience the effects of both substances. Technically, the specific effects and reactions that occur from frequent consumption of Excedrin and alcohol depend on whether you consume more alcohol versus Excedrin or more Excedrin versus alcohol.

Using significantly more Excedrin with alcohol will lead to sedation and lethargy, as well as synergistic effects resulting from mixing the two drugs.

People who use alcohol and Excedrin may experience effects such as:

• Reduced motor reflexes from excess and alcohol
• Dizziness from alcohol and Excedrin
• Nausea and vomiting with Excedrin

Some people may also experience great euphoria. depression, irritability, or all three. The combination of alcohol and excedrin results in significantly more lethargy, which can easily turn into coma, attacks of respiratory depression, and death.

Alcohol vs. Excedrin

Taking Excedrin in sufficient quantities increases the risk of heart failure. In addition, people under the influence of Excedrin and alcohol may have difficulty forming new memories. With alcohol and excedrin in the human body, they get confused and don’t understand their surroundings. Due to the synergistic properties of Excedrin, when mixed with alcohol, it can cause confusion, anxiety, depression, and other psychiatric disorders.Chronic use of Excedrin and alcohol can lead to irreversible changes in the brain.

Excedrin versus Alcohol

Studies examining the effects of drugs such as Excedrin and alcohol have shown that the likelihood of parasomnia (performing tasks while sleeping) increases dramatically when Excedrin and alcohol are combined. Mixing drugs can cause serious and dangerous side effects in the body, and sleep disorders are a common side effect of drinking alcohol and Excedrin at the same time.

When a small to moderate amount of alcohol is combined with Excedrin, sleep disturbances such as sleep apnea can occur. According to the latest data from the United States Centers for Disease Control and Prevention (CDC), most emergency room visits and hospitalizations caused by excessive alcohol use have been associated with other substances, such as Excedrin.

How long after taking Excedrin you can drink alcohol

To avoid residual toxicity, it is recommended to wait until Excedrin has completely cleared your system before consuming alcohol, even in small amounts.

Excedrin and alcohol overdose

Excedrin and alcohol overdose is very common and can often be fatal. If you overdose on Excedrin, or if you are worried after mixing {drug and alcohol}, call emergency services or go to the nearest emergency room immediately. If you are concerned about someone who has taken too much Excedrin or mixed alcohol with Excedrin, call or take a First Aid specialist for immediate medical attention.The best place for you or your loved one in a medical emergency is medical observation. Be sure to tell healthcare providers that this is a mixture of Excedrin and alcohol. The combination of alcohol and excedrin increases the likelihood of a person being transferred to intensive care.

Excedrin MigraStop, tabletki powlekane, 20 szt.

Excedrin MigraStop for use in the combined treatment of headaches and migraine attacks (symptoms such as: headache, nausea, increased sensitivity to light and sound, and disturbance of daily work) with or without aura.

Composition

Substances, additives preparations: acetylsalicylic acid, paracetamol and caffeine.
Each film-coated tablet contains 250 mg of acetylsalicylic acid, 250 mg of paracetamoiu and 65 mg of caffeine.

Other ingredients of the preparation:

tablet core: niskopodsta-wiona hydroxypropyl cellulose, microcrystalline cellulose, stearic acid,

coating: Opadry YS-1-7086 (hypromelo 50 cP, titanium dwutJeneki EIJI), propylene glycol), benzoic acid (E210), Carnauba wax.

Dose

Excedrin MigraStop should be used according to the information in the leaflet or as directed by your doctor or pharmacist. If in doubt, contact your doctor or pharmacist.

Adults (over 18 years old):

Headache treatment

In case of a headache, take 1 tablet and drink it with a full glass of water. If necessary, the next tablet can be taken 4-6 hours after taking the first one.

In case of a more intense headache, you can take 2 tablets at the same time, if necessary, you can take 2 more tablets 4-6 hours after taking the first two tablets.

Excedrin MiaraStop should not be used in headaches for more than 4 days without consulting a doctor.

Treatment of migraine

In case of symptoms of migraine or migraine aura, take 2 tablets of the drug with a glass of water.

If necessary, you can take 2 more tablets with a 4-6 hour interval between doses.

Do not use Excedrin MigraStop for longer than 3 days in migraines without consulting your doctor.

Action

Acetylsalicylic acid and paracetamol reduce pain and fever, and acetylsalicylic acid also has anti-inflammatory effects.

Caffeine is a mild stimulant and increases the action of acetylsalicylic acid and paracetamol.

Indications

Excedrin MigraStop is used in the combined treatment of headaches and migraine attacks (symptoms such as: headache, nausea, increased sensitivity to light and sound, and disturbance of daily work) with or without aura.

Contraindications

When to not use the drug Excedrin MigraStop

Side effects

Like any drug, Excedrin MigraStop can cause side effects, although not everybody gets them.

Often (occurs in 1 in 10 patients)

Not very common (occurs in 1 in 100 patients)

Rare (occurs in 1 in 1000 patients)

Warnings and precautions

Other use Medicines

Tell your doctor about all recent medications, even over-the-counter medications.

In particular, tell your doctor if you are taking any of the following drugs:

Taking the drug with food and drinks

Alcohol: Ask your doctor if you can take Excedrin MigraStop or other pain relievers / antipyretics when using 3 or more alcoholic drinks per day.

Caffeine: caffeine The content in the recommended daily dose of the preparation corresponds to the content of about one cup of coffee. During the use of the drug, you should limit the intake of drugs, food or drinks containing caffeine, since too much of it can cause nervousness, irritability, insomnia, and in some cases, an increase in heart rate.

Pregnancy and lactation

If pregnant or lactating, consult a healthcare professional before use.

Do not use Excedrin MigraStop during the last three months of pregnancy because of the potential for fetal injury or difficulty in labor.

Do not use the drug during breastfeeding, as it can be dangerous for the baby.

Effects on laboratory tests

Excedrin MigraStop belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs) that can interfere with fertility.This effect disappears after the termination of the use of drugs from the NSAID group.

Use of the drug in children and adolescents

Drug Excedrin MigraStop should not be used in children and adolescents under the age of 18 years.

Driving and operating machinery

If dizziness or drowsiness occurs, do not drive or operate mechanical devices.

Delivery / acceptance of the product:

Acceptance of ordered goods is possible throughout Poland. Welcome to, in order to find out the location of the nearest pharmacy that will carry out your order. Delivery to pharmacies throughout the country is carried out free of charge within 24-72h 90,000 How does Citramon affect blood pressure, normalization of low blood pressure, reception with increased

Citramon is a popular and inexpensive drug with pain relieving action, which is available in tablets and is prescribed for headaches.Low blood pressure (hypotension) and high blood pressure (abbreviated as BP) – hypertension – often cause headaches. The question arises: citramone lowers or increases blood pressure, and for what headaches you can take the drug so as not to harm your health. Let’s figure it out.

The composition of citramone, the effect of its components on blood pressure

To answer the question of how a drug affects blood pressure, you need to know its composition. Citramon is a combined non-narcotic analgesic.The tablets contain 3 main active ingredients and excipients (cocoa, citric acid).

Citramone active ingredients:

• Acetylsalicylic acid (aspirin) – has antipyretic, analgesic, anti-inflammatory effect and slows down blood clotting. It has no effect on blood pressure.
• Paracetamol – causes antipyretic and analgesic effects. It has no effect on blood pressure.

Caffeine – has a stimulating effect on the nervous system, normalizes blood flow in internal organs, eliminates drowsiness, increases physical performance, improves mental activity.Restores low blood pressure. High pressure can lead to a deterioration in general condition. For more information on this topic, see the article Lowering or increasing coffee pressure?

Due to caffeine, citramone can increase blood pressure. The hypertensive property of tablets depends on the individual susceptibility of the organism to the drug. In addition, doctors warn that citramone is not a drug for the treatment of hypotension and helps with headaches due to a decrease in blood pressure.

Dosage of citramone to normalize low blood pressure

We have already figured out that citramone acts as an analgesic drug that indirectly normalizes low blood pressure. The instructions for the drug indicate that citramon is prescribed for pain of various origins and fever. There is no data on the hypertensive effect of the drug.

However, pills have become the most popular among hypotensive patients who suffer from frequent headaches.Doctors recommend taking citramone in such cases to alleviate the general condition, eliminate fatigue and drowsiness.

A regular citramone tablet contains 30 mg of caffeine. In most cases, this dosage is not enough for an adult to normalize low blood pressure. The minimum dosage of caffeine that stimulates the central nervous system is 50 mg. The sensitivity to a substance is influenced by the individual characteristic of the organism. Of no less importance is the frequent use of tea, coffee, cola, pepsi, which contain caffeine and can cause addiction (resistance).

To obtain a positive effect, doctors recommend taking 2 tablets of citramone once, if the action of one tablet does not relieve the headache. The pharmaceutical industry produces drugs that contain an increased dosage of caffeine: “Citramon Extra” contains 50 mg of caffeine, “Citramon Forte” – 40 mg of caffeine.

Reception of citramon at high pressure

Headaches with high blood pressure are relieved by antihypertensive drugs, which are prescribed for constant use.Citramon can be used for pain syndrome of a different localization, but taking into account its composition. The content of caffeine in a 30 mg tablet is 10 times lower than the daily dosage of a substance that can significantly affect the increase in blood pressure. Against the background of taking antihypertensive drugs, this dosage is too low to cause a deterioration in the general condition.

However, the risk of increased blood pressure is high in the case of taking several tablets of citramone, especially in people with essential hypertension who refuse constant treatment with antihypertensive drugs.Other analgesics that do not contain caffeine and which have a more pronounced analgesic effect can be used to relieve pain.

Total

Taking citramone effectively relieves headaches associated with a decrease in blood pressure. The tablets eliminate other signs of hypotension, such as drowsiness, fatigue, memory impairment, absent-mindedness. For the treatment and prevention of hypotension, citramone is not prescribed, it is recommended only as an ambulance for pain syndrome.With high blood pressure, it is better to refuse taking pills.

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# xcedrin Instagram posts (photos and videos)

“Give something from your head”
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Save the post and send to friends💜
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What drug do you drink when you have a headache? How does your head hurt?
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We will talk about the most common types of pain.
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1️⃣ Tension headache.The reasons are long-term work at the computer and phone, lack of sleep, uncomfortable posture in a dream, etc.
Stress – we were nervous, the adrenal glands released adrenaline, which caused a spasm of not only blood vessels, but also muscles.
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▫️Signs
Pain, constricting like “helmet”, “hoop”, pressing, not pulsating, dull. It is localized, as a rule, in the fronto-parietal or cervico-occipital region.
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💊What will help? (Flipping through the carousel)
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2️⃣Migraine – pulsating pain, localized in one half of the head, irritation and increased pain for sounds and light, can last from several hours to three days.⠀
Stress, insomnia, odors, harsh light, certain foods, critical days, etc. can provoke a migraine attack.
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Sometimes it is preceded by an aura: for example, the field of vision narrows, the tips of the fingers become numb, tingles of the lips, tongue, half of the face.
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3️⃣Vascular pain
Reasons – violation of vascular tone, doctors call it – “vegetative-vascular dystonia”
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Pulsing character. Localization – most often the whiskey, the back of the head.
Blood pressure “jumps”: it is normal, then high or low.⠀
4️⃣How to find out a headache in atherosclerosis of cerebral vessels?
Dull pain, pressing, may be accompanied by dizziness, darkening in the eyes, decreased attention, memory
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5️⃣Headache with high or low blood pressure.
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There are no special signs of such pain, more often it is spilled, oppressive and, most importantly, moderate.
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❗The information is grouped, taking into account the composition of drugs and the pathogenesis of headaches.
Before using the drugs, you need to consult a doctor.
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Before taking medications, you need to analyze your condition in order to make the right choice and not harm ☝️
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