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Cialis (Tadalafil) Reviews | Everyday Health

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Sexual / Libido enhancementHypertensionErectile DysfunctionSexual dysfunctionPulmonary HypertensionBenign Prostatic Hyperplasia

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5 Stars

Posted 9 months ago (9/29/2022) 5

Rated for Erectile Dysfunction Report

ED due to a stressful job. I’m 44 and wife is 38. She has a high sex drive which added to the stress as I could only satisfy her with oral sex but knew she wanted more. Taking 10mg Tadalafil for 2 months now and what a difference. Within 30 mins, if we are getting horny together, I manage to get a good firm erection every time without fail. My confidence has increased so much because my erection lasts the whole session until I ejaculate. It is maintained even when we change sexual positions a few times. Lasts up to 36 hours. Weekend sex is great for us again, we always like it on a Fri night but if I’ve taken a tablet on a Fri evening, it means I can spring to action when we first wake up on Sat and then later that afternoon or evening when she wants it again. Back to how we were a few years ago now, she’s loving getting her legs spread and the regular attention. Feels good knowing my bulge will respond when she starts playing with it. First few times got flushing in the face but don’t get it at all now.

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4 Stars

Posted 10 months ago (8/11/2022) 4

Rated for Sexual / Libido enhancement Report

I’m on 20 mg a day for ED. After a week it was working great. Morning and spontaneous erections for the first time in years (I’m 59). After a few months it seemed to lose it’s potency and the positive effects died down. I’m wondering if you should take periodic breaks to maintain it’s effectiveness. No answers on the internet.

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5 Stars

Posted 12 months ago (6/21/2022) 5

Rated for Erectile Dysfunction Report

This was worth the visit to see the urologist — even to have the dreaded prostate exam first! I told him I wanted a Rx for tadalafil — he asked no awkward questions; he said, “sure. ” I’m not in a relationship. I wanted this just to feel happy and healthy. I’m 65 and have had ED issues since I was 40. I am truly amazed at this drug! Its developer needs to get a major award for the impact it has had on so many guys. I love being hard in the morning in bed. I love being semi hard in the shower. I love feeling my loins stirring sometimes during the day. I just love tadalafil! My insurance will not cover it. So without insurance, it’s over $900 for a 90 day supply. With Good Rx, it’s three cents a day. Three cents a day for the joy of having hard, healthy erections again. I am truly a very happy customer. I can’t imagine any reason to stop taking this 5 mg daily.

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5 Stars

Posted 14 months ago (4/19/2022) 5

Rated for Erectile Dysfunction Report

I am a 35 yr old man and have been having ED due to high work and life stress. After taking this the first day, I felt more hornier and easily erect at the slightest sexy thoughts. I felt more confident as it brings me back to my 18 year old. My dick was hard during masturbation and maintained throughout. Small side effects headache only. Manageable

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4 Stars

Posted 15 months ago (3/15/2022) 4

Rated for Erectile Dysfunction Report

“I’ve been using viagra for the last 15 month which has been good but the side effects was getting a bit much, so I got on to my docs about it and they said to try tadalafil 10mg which I’ve been on now for a week. Been taking every couple of days for the best effect and wow is it good. Get rock hard penis when ever I want and I can do more rounds with my wife lol. And she has commented about my flaccid penis been bigger too which I did notice myself. In fact even at the lads at swimming baths seem to have noticed too lol. Couple have commented thought I had a semi on which I didn’t but just a lot fuller with the tablets

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5 Stars

Posted 16 months ago (2/19/2022) 5

Rated for Sexual / Libido enhancement Report

This drug is unbelievable!!!!! Im 52 years old and started having ED problems about two years ago. Started taking about six months ago. Im in great shape andI feel like I am 19! This is a wonder drug. The only problem I have is getting it prescribed. Im prescribed 8 pills of 10MGs a month . I like to take 2 pills a week but my pharmacy keeps playing games with me only allowing me 4 pills a month. Would love to take it every day.

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5 Stars

Posted 16 months ago (2/14/2022) 5

Rated for Erectile Dysfunction Report

Three years ago, at the age of 62, I was diagnosed with having prostate cancer. My treatment plan consisted of 18 months of hormone therapy, 25 sessions of external beam radiation therapy and LDR brachytherapy. Prior to my treatments, I had absolutely no problem with erectile dysfunction. After the completion of my treatments, I experienced a severe case of erectile dysfunction. My wife and I had been very sexually active for 40 years. We discussed this issue with my urologist and he recommended that I take 20 mg of Tadalafil. The first time I took a pill, we were both shocked on how well it worked. This pill worked perfect for me with no side effects. Note: Don’t take this pill expecting an immediate erection. You have to first be stimulated. Just a few minutes of foreplay works for me. Three years later, my wife and I are enjoying sex as we always did. Hopefully, this pill will be effective for other men. I would highly recommend that any man experiencing erectile dysfunction try this medication.

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4 Stars

Posted 16 months ago (2/12/2022) 4

Rated for Erectile Dysfunction Report

53 Year old married guy here that started experiencing problems getting an erection when needed. Made the decision to start off with Tadalafil 5 mg as required. Can’t say enough how it changed our sex life for the better. I take the medication 30 min to an hour before sex and WOW….with the minimum stimulation I get as hard as a rock ! My wife commented on the thickness and solid stiffness which keeps my cock throbbing throughout – it even looks fuller when not erect. The effects lasts for a day and a half and I now often edge my hard cock for an hour or more, enjoy a massive orgasm with a substantial load, then wait an hour or two and my cock will be ready to get rock hard again to satisfy my wife. Slight hot flushes in the face and slight headache but nothing serious, will def continue and strongly advise this medication !

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5 Stars

Posted 17 months ago (1/18/2022) 5

Rated for Benign Prostatic Hyperplasia Report

“I’m 54 and have experienced increasing ED problems over the past 2 years. In November I was diagnosed with early stage prostate cancer and also have BPH which is the cause of my ED. I’m not having any treatment beyond active surveillance and luckily have only mild symptoms (increase in frequency but that’s it. No night time disturbance, etc). Annual health screening detected the cancer / BPH. Started taking daily 5mg Tadalafil in November and the results are superb. No side effects, except when combined with alcohol I sometimes get a stuffy nose. Erections are very strong and sex is very pleasurable again. (Being circumcised it does seem to flare out the glans a bit more.) I’ve also seen a reduction in frequency of urination. Really pleased with the drug which working well for me.

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5 Stars

Posted 18 months ago (12/5/2021) 5

Rated for Sexual / Libido enhancement Report

I am a 70 year old with a 40 year old wife. Although I could get an erection, it was certainly starting to not be as hard and tended not to stay hard for very long, leading to frustration for both of us. I was getting to the point that I was losing interest in sexual activity. I had used Viagra previously but found it to be inconvenient having to take it in advance of sexual activities. I discovered Tadalafil Daily (5mg) and after just a few days of taking it, I could produce an erection on demand provided there was sexual stimulation from my wife. I now get rock hard again, and can stay hard throughout the performance and sometimes beyond. My wife is very appreciative of this tiny pill I take daily as am I.

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5 Stars

Posted 19 months ago (11/16/2021) 5

Rated for Erectile Dysfunction Report

From zero to hero; 5mg done wonders; my gf got inspired; had multiple times in one night.. I am 51 and my gf is just 30; she was commenting “Never had sex like that before” tried a lot of positions; rock solid

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5 Stars

Posted 20 months ago (10/12/2021) 5

Rated for Sexual / Libido enhancement Report

65 year old and decided to take tadalafil out of curiosity and overhearing gossip at the gym. Heard that some guys take it together with daily protein supplements which provide with more muscle ‘pump’. The effects it had on me – a harder and more frequent and spontaneous erection with comments from wife that my erection appeared thicker with the veins more pronounced – when not erect my penis had more ‘swagger’. Highly recommended

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5 Stars

Posted 21 months ago (9/19/2021) 5

Rated for Sexual / Libido enhancement Report

82 years old first-time user of any male enhancement pills. Partly out of safety consideration, and partly out of curiosity, I asked my doctor to prescribe me 5mg prescription. The effect is evident, turnning me from frigid to hot pursuer. The doctor also prescribed me 20mg sildennafil citrate, but it doesn’t have any effect on me.

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5 Stars

Posted 22 months ago (8/26/2021) 5

Rated for Benign Prostatic Hyperplasia Report

48yo was prescribed and have been taking 5mg generic daily to help with BPH and nocturnia symptoms. Noticed a gradual decrease with the symptoms and were nearly gone after 2 weeks. Could not be happier with the results. No negative side effects experienced, but after a couple days started getting much longer lasting morning wood and spontaneous erections throughout the day.

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1 Stars

Posted 25 months ago (6/1/2021) 1

Rated for Sexual / Libido enhancement Report

46yrs old-overseas deployments keep me in a brain funk-seariously hot wife-outstanding physique-perpetualy 18- no negative effects for me but the muscular pain is crippling- I still hurt-Abs hurt to touch all of them-I feel this will hurt my fitness routine and time on the hamster wheel-this is awful seriously unpleasant any advice? Thank you.

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5 Stars

Posted 25 months ago (5/25/2021) 5

Rated for Erectile Dysfunction Report

I took bluechew sildenafil for about a year, which worked fairly well for me. But after being introduced to tadalafil, I’ll never go back. I take 10mg daily with my usual vitamin pack. This stuff works! I now get erections when I’m driving the car and my wife moves my hand onto her inner thigh. It’s like I’m 18 again! I always had a problem losing an erection mid way through sex. Now I have confidence in knowing I’m going to stay hard and even perform multiple times when needed. The only side effect I’ve noticed is a bit of lightheadedness when taken with some medications. But nothing severe. I would absolutely recommend this medication to any and all ED sufferers.

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4 Stars

Posted 26 months ago (4/24/2021) 4

Rated for Sexual / Libido enhancement Report

Someone below said the EXACT thing I’m finding….that I need 10mg daily for it to be effective, AND I need to do that at least 4 to 5 days before expecting to get hard on demand. Maybe 15mg is better I’m starting to experiment.

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5 Stars

Posted 26 months ago (4/16/2021) 5

Rated for Benign Prostatic Hyperplasia Report

My doctor prescribed Tadalafil 5mg daily for treatment of BPH and that it would be a benefit it treatment of ED! WOW! I can easily get hard full girth erections! Ejaculation is delayed with an explosive orgasm with more cum than I have been able to produce in a long time! This truly is a “Wonder Drug”

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5 Stars

Posted 26 months ago (4/15/2021) 5

Rated for Benign Prostatic Hyperplasia Report

I take Tadalafil for BPH but also the benefit of ED. Wow, what a great drug! Not only has it helped with the BPH but I can get an extremely hard and full girth erection easily! Better stamina, stronger ejaculation with increased volume of cum! I’m 71 and perform like I’m 30 again! .5 daily dose does it for me!

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4 Stars

Posted 27 months ago (4/4/2021) 4

Rated for Erectile Dysfunction Report

I am on med because of an proctectomy surgery. 5mg daily 26 days now something is starting to happen, but feel like I have to pee when erection is achieved.

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4 Stars

Posted 27 months ago (3/27/2021) 4

Rated for Sexual / Libido enhancement Report

Biggest thing I could share is i need 10 mg daily for it to be effective, and need to take regularly, if I’m off it might take 4 or 5 days before I come back on line

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5 Stars

Posted 27 months ago (3/17/2021) 5

Rated for Sexual / Libido enhancement Report

Erections are rock solid and last as long as I want them to. Next erection can return just as hard 10 minutes after ejaculation. Other benefit is the swagger of my penis when it’s flaccid… it is almost 2 inches longer, heavy, and thicker than ever before

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5 Stars

Posted 27 months ago (3/12/2021) 5

Rated for Erectile Dysfunction Report

Outstanding!!! I’m a 55 year old male that had a problem maintaining erections more than 15 minutes. I’m now taking 5mg of Cialis daily and it’s like I’m 18 again. Rock hard erections whenever I need them, easily last long enough to satisfy my lover multiple times and no side effects. And I swear I’m at least 1-1.5” longer. But the erections are like steel. Unbelievable! And multiple times a day when aroused.

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5 Stars

Posted 27 months ago (3/8/2021) 5

Rated for Erectile Dysfunction Report

Doctor put me on the 20mg dosage 10+ years ago, can’t have intercourse without. Side effects, slight headache also erections throughout the next day. Wife insisted we take full advantage of erections the next day (get our moneys worth). To our surprise pill works better for us the next day!! At 62 years old having more sex then in my 30s.

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5 Stars

Posted 27 months ago (3/6/2021) 5

Rated for Erectile Dysfunction Report

I am a 72 year old, very happily married for 48 years to a beautiful woman, now 71 (5’4″, 125 lb.). About a year ago I began to experience ED which led to frustration in our love-making sessions for both of us. Finally, I decided to ask my MD for a script for Cialis and he gave me 20 mg. The result has been amazing for both of us! It is especially exciting that she initiates discussion and activity for sex, saying it is so relaxing now with no worries about trying to time things just right (if I can maintain an erection). I can do so now with no concerns and we both very much appreciate that. I do get a low-grade headache with each pill, but believe me it is well worth it. I would certainly recommend trying Cialis for anyone experiencing ED, please remember it is a medical condition lust like many other conditions that we experience, especially as we grow older. It may not work for everyone and side-effects could be an issue as with any drug. But if successful, both will be happy and satisfied. I usually take mine ate at night and know during the night that it has kicked in – my wife has told me she knows it has too and her excitement begins too

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5 Stars

Posted 28 months ago (3/2/2021) 5

Rated for Erectile Dysfunction Report

This stuff works!! I hate taking pills, but had to do something. Had a difficult time getting it up and keeping it going. I hear this happens at my age, 43. Went to the doctor and he prescribed cialis, 5mg a day. First time taking it had some side effects, flushing of the face, terrible headache for a day, and stuffy nose. Second dose only had the face flushing, third dose and on no side effects! From the first pill, sex has been awesome!!! Can get hard enough for wife to be on top, do any position anytime. Got my confidence back. This stuff is the real deal

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5 Stars

Posted 28 months ago (2/3/2021) 5

Rated for Erectile Dysfunction Report

I’ve had intermittent erectile dysfunction problems for years now that have gotten worse with age I’m 44 now and first time it happened I was 33. I used to use a pill you could find in sex shops called C***star but they no longer make it, and more recently Rhino pills. Both were modestly successful. My doctor thought the problem was anxiety related so he put me on buspar but that didn’t help much at all. Finally after pleading with him he prescribed Viagra which solved the problem but presented another problem of it being very difficult to impossible to climax. Finally after a few months my Dr relented and had me try Cialis. It has been life changing. Just give it at least 2 hours to work. I tried sex after about 15 mins and had my same issues but otherwise it saved my marriage and made enjoy sex again. Sex had become a mostly disappointing chore and although sometimes I could pull it off I had more failures than success but now no problems. Only downside like I said is the wait time to work.

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5 Stars

Posted 29 months ago (1/25/2021) 5

Rated for Erectile Dysfunction Report

I’m on some psych meds that interfere with my erection and testosterone levels. My urologist put me on 5 MG of generic cialis daily…holy SH!T I have the ability to get and stay hard at anytime of the day or night. I got the confidence in the bedroom I used to have when I was half my age! I highly recommend this drug if you are struggling with ED.

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3 Stars

Posted 30 months ago (12/30/2020) 3

Rated for Erectile Dysfunction Report

I tried Sildenafil and never was satisfied with it even taken the larges dose (100mgs) so I got my Dr. to give me a script for Tadalafil. I thinks it works better, but still do not get very hard, just firm like a hot dog and sometimes I lose even that. I take the 20 mgs dose and wait about 1 and 1/2 hours. Am I waiting to long or not long enough? When I am able to penetrate, things go well. I have not had night or morning wood, as soon as I come it loses all firmness. Would like to hear some input on this and any advice. Thanks John

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1 Stars

Posted 30 months ago (12/6/2020) 1

Rated for Sexual / Libido enhancement Report

Healthy male. Took 1x 5mg only once. Severe flushing. Body temperature extreme hot and then freezing. Raised my normal blood pressure. Been 48hrs since taking and slight improvement in side effects. Please consider side effects before taking.

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5 Stars

Posted 31 months ago (11/15/2020) 5

Rated for Sexual / Libido enhancement Report

I’m 27 and just use this for performance enhancement I take the 2. 5 daily dose and have been for 4 months now. I noticed a couple of things. First this makes your dick look bigger like your always semi erect. My erections are crazy on this solid as a rock. I also get alot of random boners maybe 4 or 6 per hour. Also when I work out I feel a much more intense pump. Also be prepared this makes you get random night boners while you sleep and in return you get wet dreams. I have woken up to cum soaked boxers and sheets multiple times now. Also some times you get boners at the worst times I was at the grocery store and out of nowhere rock hard stiffy. I had to hide behind my cart and think of any turn offs to make it soft again. Also be careful if you like to run or jog the friction will make you hard really fast. Overall I like this feels like I’m 18 again. I highly recommend cialis / tadalafil.

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5 Stars

Posted 32 months ago (10/9/2020) 5

Rated for Sexual / Libido enhancement Report

Having reached a real “dip” in our sex life (im 57 wife 59 ) i picked up courage and went to pharmacist ( wife had noticed my lack of interest and erections) was recommended 5mg daily , results were Wow ,took in evening before bed and woke up in midle of night and had full erection ,went back to bed and woke early with another full erection and i mean full ,rock solid out the top of my pajama bottoms ! wife noticed as i tried to “deal “. with it…had we had great full penetration sex, orgasm and ejaculation were strong too .continued to take for a couple of nights then decided to only use a few days a week as i was getting strong erections every time i had a shower or just looking at wife’s legs !

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5 Stars

Posted 34 months ago (8/17/2020) 5

Rated for Erectile Dysfunction Report

Taking the 2.5g daily dosage – great and ‘impressive’ results after 2 days. Erection is now much harder for longer – also penis is now much thicker much to my wife’s enjoyment. When in a flaccid state penis also appears to be more ‘hung’. Expect to get hard during the night while asleep ( my wife’s observation) and to wake up erect. Highly recommended

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5 Stars

Posted 35 months ago (8/1/2020) 5

Rated for Erectile Dysfunction Report

Well, I’ve done the Viagra method, with limited results and thought I should try Cialis. I did a 3 day run with the medication. First night, 20 ml tabs, the next 2 I broke one in half, so 10 ml each of the following nights. I also took then early afternoon to get through any side effects which for me was a mild headache (Advil took care of that) and mild sinus congestion, but easily tolerated. The only way I can explain the result is “omfg, WOW”. When I was with my girl those 3 nights, it didn’t even need to be touched and I was rock hard. The erection outlasted me. Took a break, and it was still ready for more. Orgasms came when I wanted it to, which before I had a hard time reaching that point. I’ve had more sex in the last 3 days then in months combined. If you haven’t tried it, DO!!!

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5 Stars

Posted 36 months ago (6/24/2020) 5

Rated for Erectile Dysfunction Report

An effective drug in my case. There were violations in the reproductive system, the soldier refused to stand still. For treatment, I chose between Viagra (http://bit.ly/viagra44) and Cialis (http://bit.ly/cialis-enter-shop), but settled on the latter. Cialis seems to be an improved form of Viagra, in simple words. All treatment took me no more than 2 months. The price spent on cialis for these 2 months is about $ 120. Dosage 20 mg / day (consult your doctor).

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Cialis Reviews – What You Need to Know Before Using


Cialis rated
4.49/5 in 476 reviews
from verified
Dr Fox customers.

Read 476 reviews

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STAR RATINGS:

Cialis 5mg

Certainly good and works well specially in such hectic stressful times

02/06/2023 01:33
Anonymous Verified

Cialis 20mg

Brilliant. Absolutely brilliant

29/05/2023 18:19
Anonymous Verified

Cialis 20mg

Very good deal

15/05/2023 10:46
A. Costa Verified

Cialis 20mg

Fantastic product

10/03/2023 00:28
Anonymous Verified

Cialis 20mg

The only one that works for me! Definitely gonna try it with my gf

02/03/2023 12:17
Anonymous Verified

Cialis 20mg

Very happy

25/02/2023 10:07
Anonymous Verified

Cialis 20mg

To me these were fake, they did very little. I have used these before, but got from another site and they were excellent, but these ones I got from doctorfox site did very little

Dr Fox response:
Thank you for your review and very sorry the tablets did not have the desired effect on this occasion as they did when supplied previously. Please note Cialis and other oral ED tablets will only be effective with sexual stimulation. Cialis helps keep the blood in the penis once aroused. It will not initiate blood flow to the penis, so if you are not sexually aroused, the treatment will fail. It is advised to repeat the attempt several times. Our doctors are available to discuss if you need medical advice. All medicine supplied is UK licensed and sourced through regulated supply chains from manufacturers. New individual QR barcodes on medicine packs ensure counterfeit medicines cannot enter this supply chain. Unwanted medicine may be returned for a full refund.

29/01/2023 18:59
K. Swan Verified

Cialis 10mg

Excellent, will buy again

02/01/2023 20:01
Anonymous Verified

Cialis 20mg

Great product. One pill lasted almost 3 days 🙂

26/11/2022 17:20
Anonymous Verified

Cialis 20mg

no comment

15/11/2022 18:17
Anonymous Verified

Cialis 20mg

Definitely does the job for the weekend! 😉

15/11/2022 16:44
Anonymous Verified

Cialis 20mg

The medication was fantastic. The communication was brilliant re: delivery.

28/10/2022 14:07
K. Fitch Verified

Cialis 20mg

Always reliable

16/10/2022 09:44
P. Botting Verified

Cialis 20mg

Excellent! Worked wonders!

12/10/2022 05:30
J. Poole Verified

Cialis 10mg

Effective in half an hour

07/10/2022 22:00
Anonymous Verified

Cialis 20mg

Fantastic, couldn’t be happier

05/10/2022 14:57
Anonymous Verified

Cialis 2. 5mg

Brilliant just brilliant

18/09/2022 23:02
Anonymous Verified

Cialis 5mg

Seem to be much better than the generic. But it might be in my head.

30/08/2022 21:48
Anonymous Verified

Cialis 5mg

This is amazing, much better and more natural than taking a tablet an hour before.

15/08/2022 15:59
Anonymous Verified

Cialis 20mg

Just perfect. They are well worth the money

17/07/2022 15:44
P. Robinson Verified

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Cialis instructions for use: indications, contraindications, side effects – description Cialis tab., cover. film coated, 20 mg: 1, 2, 4 or 8 pcs. (2904)

💊 Composition of Cialis ®

✅ Use of Cialis ®

Keep it for yourself

Look for alternatives

Interaction

Description of the active ingredients of the preparation

Cialis ®
(Cialis ® )

The scientific information provided is general and cannot be used to make decisions.
decisions about the use of a particular drug.

Renewal date: 2020.05.25

Marketing authorization holder:

ELI LILLY VOSTOK, S.A.
(Switzerland)

Manufactured:

ELI LILLY & Company Limited

(UK)

ATX code:

G04BE08

(Tadalafil)

Active substance:
tadalafil
(tadalafil)

Rec.INN

WHO registered

Dosage form

Cialis ®

Tab. , coated film coated, 20 mg: 1, 2, 4 or 8 pcs.

reg. No.: P N014761/01
from 05.03.09
– Indefinitely

Release form, packaging and composition
Cialis

®

Film-coated tablets yellow, almond-shaped, marked “C 20” on one side.

Excipients : lactose monohydrate – 245.195 mg, hyprolose (hydroxypropylcellulose) – 8.05 mg, croscarmellose sodium – 22.4 mg, microcrystalline cellulose – 52.5 mg, magnesium stearate – 0.875 mg, sodium lauryl sulfate – 0.9 8 mg.

Composition of the film shell: Opadry II yellow (lactose monohydrate, hypromellose, titanium dioxide, triacetin, iron oxide yellow) – 14 mg.

1 pc. – blisters (1) – packs of cardboard.
2 pcs. – blisters (1) – packs of cardboard.
2 pcs. – blisters (2) – packs of cardboard.
2 pcs. – blisters (4) – packs of cardboard.

Clinical and pharmacological group:

Drug for the treatment of erectile dysfunction. PDE5 inhibitor

Pharmacotherapeutic group:

Erectile dysfunction treatment – PDE5 inhibitor

Pharmacological action

An agent for the treatment of erectile dysfunction, is a reversible selective inhibitor of specific PDE5 cGMP. When sexual arousal causes local release of nitric oxide, PDE5 inhibition by tadalafil results in an increase in cGMP levels in the corpus cavernosum of the penis. The consequence of this is the relaxation of the smooth muscles of the arteries and the flow of blood to the tissues of the penis, which causes an erection. Tadalafil is ineffective in the absence of sexual stimulation.

In vitro studies have shown that tadalafil is a selective PDE5 inhibitor. PDE5 is an enzyme found in the smooth muscles of the cavernous body, in the smooth muscles of the vessels of internal organs, in skeletal muscles, platelets, kidneys, lungs, and cerebellum.

The effect of tadalafil on PDE5 is more active than on other phosphodiesterases. Tadalafil is 10,000 times more active against PDE5 than against PDE1, PDE2, PDE4, which are localized in the heart, brain, blood vessels, liver and other organs. Tadalafil is 10,000 times more active at blocking PDE5 than PDE3, an enzyme found in the heart and blood vessels. This selectivity for PDE5 over PDE3 is important because PDE3 is an enzyme involved in cardiac muscle contraction. In addition, tadalafil is approximately 700 times more potent against PDE5 than against PDE6, which is found in the retina and is responsible for phototransmission. Tadalafil is also 10,000 times more active against PDE5 than its effect on PDE7-PDE10.

Acts within 36 hours. The effect appears already 16 minutes after ingestion in the presence of sexual arousal.

Tadalafil in healthy individuals does not cause a significant change in systolic and diastolic pressure, compared with placebo in the supine position (mean maximum decrease is 1.6/0.8 mm Hg, respectively) and standing (mean maximum decrease is 0.2/4.6 mm Hg. article respectively). Tadalafil does not cause a significant change in heart rate.

Tadalafil does not cause changes in color recognition (blue / green), due to its low affinity for PDE6. In addition, there is no effect of tadalafil on visual acuity, electroretinogram, intraocular pressure and pupil size.

There was no clinically significant effect on sperm characteristics in men who took tadalafil at daily doses for 6 months.

Pharmacokinetics

Tadalafil is rapidly absorbed after oral administration. C max is reached after an average of 2 hours. The rate and extent of absorption do not depend on food intake. The pharmacokinetics of tadalafil in healthy individuals is linear with respect to time and dose. In the dose range from 2.5 to 20 mg AUC increases in proportion to the dose. C ss in plasma are achieved within 5 days when taking the drug 1 time / day.

The pharmacokinetics of tadalafil in patients with erectile dysfunction is similar to the pharmacokinetics of the drug in individuals without erectile dysfunction.

V d is about 63 liters, which indicates that tadalafil is distributed in body tissues. At therapeutic concentrations, 94% of tadalafil binds to plasma proteins. In healthy individuals, less than 0.0005% of the administered dose was found in semen.

Metabolized with the participation of the CYP3A4 isoenzyme. The main circulating metabolite is methylcatecholglucuronide, which is 13,000 times less potent against PDE5 than tadalafil, so this metabolite is unlikely to be clinically relevant.

In healthy individuals, the average clearance of tadalafil when taken orally is 2.5 l / h, and the average T with urine (about 36%).

In patients with mild renal insufficiency (CC from 51 to 80 ml / min) or moderate severity (CC from 31 to 50 ml / min), AUC is greater than in healthy individuals.

Indications of the active substances of the drug

Cialis

®

Erectile dysfunction.

Open list of ICD-10 codes

F52.2 Insufficiency of genital reaction (psychogenic impotence)
N48.4 Organic impotence

Dosing regimen

The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

Middle-aged men are recommended to take a dose of 20 mg at least 16 minutes before expected sexual activity, regardless of food intake. Patients may attempt intercourse at any time within 36 hours after ingestion in order to establish an optimal response time to tadalafil. The maximum frequency of admission is 1 time / day.

Side effects

Most common: headache, dyspepsia.

Possible: back pain, myalgia, nasal congestion, flushing of the face.

Rare: eyelid edema, eye pain, conjunctival hyperemia, dizziness.

Contraindications for use

Simultaneous use of drugs containing any organic nitrates; children and adolescents up to 18 years of age; hypersensitivity to tadalafil.

Use in pregnancy and lactation

The drug is not used in women.

Use in hepatic dysfunction

With extreme caution and only in case of emergency, it is possible to use tadalafil in patients with severe hepatic insufficiency.

Use for impaired renal function

With extreme caution and only if absolutely necessary, it is possible to use tadalafil in patients with severe renal insufficiency (CC ≤ 30 ml / min).

During treatment with tadalafil, patients with moderate renal insufficiency (CC from 31 to 50 ml / min) were more likely to experience back pain compared with patients with mild renal insufficiency (CC from 51 to 80 ml / min) or healthy volunteers. In patients with CC ≤50 ml/min, tadalfil should be used with caution

Use in children

Contraindicated in children and adolescents under 18 years of age.

Special instructions

With extreme caution and only in case of emergency, it is possible to use tadalafil in patients with severe renal insufficiency (CC≤30 ml / min) and severe hepatic insufficiency.

During treatment with tadalafil, patients with moderate renal insufficiency (CC from 31 to 50 ml / min) were more likely to experience back pain compared with patients with mild renal insufficiency (CC from 51 to 80 ml / min) or healthy volunteers. In patients with CC≤50 ml/min, tadalafil should be used with caution.

Therefore, the treatment of erectile dysfunction, incl. with the use of tadalafil should not be performed in men with heart conditions in which sexual activity is not recommended.

The potential risk of developing complications during sexual activity in patients with diseases of the cardiovascular system should be considered: myocardial infarction within the last 90 days; unstable angina or angina that occurs during intercourse; chronic heart failure (functional class II and above according to the NYHA classification) that has developed within the last 6 months; uncontrolled heart rhythm disturbances; arterial hypotension (BP less than 90/50 mm Hg) or uncontrolled arterial hypertension; stroke within the last 6 months.

Tadalafil should be used with caution in patients with a predisposition to priapism (eg, sickle cell anemia, multiple myeloma, or leukemia) or in patients with an anatomical deformity of the penis (eg, angulation, cavernous fibrosis, or Peyronie’s disease).

The patient should be informed of the need for immediate medical attention in the event of an erection lasting 4 hours or more. Untimely treatment of priapism leads to damage to the tissues of the penis, as a result of which a long-term loss of potency may occur.

No cases of priapism have been reported with tadalafil.

Tadalafil is not recommended in combination with other treatments for erectile dysfunction.

Drug interactions

Tadalafil is mainly metabolized by the CYP3A4 enzyme. The selective CYP3A4 inhibitor ketoconazole increases AUC by 107%, while rifampicin reduces it by 88%.

Although specific interactions have not been studied, protease inhibitors such as ritonavir and saquinavir, as well as CYP3A4 inhibitors such as erythromycin and itraconazole, may increase the activity of tadalafil.

While taking an antacid (magnesium hydroxide / aluminum hydroxide) and tadalafil, the rate of absorption of the latter decreases without changing its AUC.

Tadalafil enhances the hypotensive effect of nitrates. This occurs as a result of the additive action of nitrates and tadalafil on nitric oxide and cGMP metabolism. Therefore, the use of tadalafil in patients receiving nitrates is contraindicated.

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Cialis ® . Description of the drug in the reference book Vidal.

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  • Ivan

    September 24, 2021

    A good remedy, the main thing is not to overdo it with a dose

    90 005 I liked that the drug works very effectively, while the price is average. It varies a lot in different pharmacies, somewhere around 800 hryvnia, somewhere for 1000. Unremarkable pills, taken half an hour before sexual intercourse, approximately, the result is amazing! But, one day, I decided to take two pills, and it was a mistake,… Read review I liked that the drug works very effectively, while the price is average. It varies a lot in different pharmacies, somewhere around 800 hryvnia, somewhere for 1000. Unremarkable pills, taken half an hour before sexual intercourse, approximately, the result is amazing! But, one day, I decided to take two pills, and it was a mistake, an insidious mistake. Not only did the effect last too long and even when it was no longer needed, but a severe headache, muscle pain and some kind of weakness in the body also began. Of course, I was scared then, but then I read that these are side effects from an overdose. Fortunately, it was small, and I was quickly released, relatively. I drank a lot of water very much, took a warm bath. In general, I advise the tool, just follow the rules of the instructions, do not step on my rake.

    Helpful feedback? September 21, 2020

    good drug “, but also for the treatment of erectile dysfunction in men. The course intake of small dosages of Cialis gives an amazing result. The drug is well tolerated, it does not cause addiction and adverse reactions. Perhaps the best drug that today you can buy in a pharmacy. A really good drug not only for a one-time raising of the “rod”, but also for the treatment of erectile dysfunction in men. The course intake of small dosages of Cialis gives an amazing result. The drug is well tolerated, it does not cause addiction and adverse reactions. Perhaps the best drug that today you can buy in a pharmacy.

    Helpful feedback? 6 Reply Show answer (1)

  • Oleg

    September 10, 2020

    05 the problem is unpleasant, the problem is delicate, but as it is. For me, Cialis has become a solution, because there are no problems after taking it and does it really work without fail? What more could a man want in his prime? the problem is unpleasant, the problem is delicate, but as it is. For me, Cialis has become a solution, because there are no problems after taking it and does it really work without fail? What more could a man want in his prime?

    Helpful feedback? 7 Reply

  • guest

    September 4, 2020 then he bought the drug on advice, for big money. As a result, Cialis turned out to be the best. When the problems started, I tried a lot of things, even in Germany I bought some drug on the advice, for big money. As a result, Cialis turned out to be the best.

    Helpful feedback? Reply

  • Dmitriy

    September 16, 2019

    Market leader functions. Almost no side effects, lasts up to 35 hours, combined with alcohol. Well, it’s just a fairy tale. Unless, the price bites, but here you can resort to the help of Tadalafil-sz Cialis is the best drug for the treatment of erectile dysfunction. Almost no side effects, lasts up to 35 hours, combined with alcohol. Well, it’s just a fairy tale. Unless, the price bites, but here you can resort to the help of Tadalafil-ss

    Helpful feedback? 38 Reply

  • Semen Root

    September 28, 2017

    At times it helps perfectly, but in general it does not solve the problem, then it was treated with smartprost. I thought that after Cialis there should be no problems at all. At times it helps perfectly, but in general it does not solve the problem, then it was treated with smartprost. I thought that after Cialis there should be no problems at all.

    Useful feedback? 41 Reply

  • org/Review”> Semen Root

    September 28, 2017

    At times it helps perfectly, but in general it does not solve the problem, then it was treated with smartprost. I thought that after Cialis there should be no problems at all. At times it helps perfectly, but in general it does not solve the problem, then it was treated with smartprost. I thought that after Cialis there should be no problems at all.

    Useful feedback? 46 Reply Show answer (1)

  • Guest

    May 9, 2017

    Cialis

    I bought generic Cialis, many times cheaper, but the effect is the same, I recommend it to everyone! I bought generic Cialis, many times cheaper, but the effect is the same, I recommend it to everyone!

    Useful feedback? 51 Reply

  • guest

    December 6, 2016 nyak for a day was. on the advice of a seasoned effect, there was almost no. I have hr. prostatitis. as a child, I had polynephritis, which is a disease of the kidneys. So, apart from palpitations and pain in the kidneys, I couldn’t sleep, I didn’t feel anything. okay, I didn’t drink a double dose so that I had tetanus for a day. on the advice of a seasoned effect, there was almost no. I have hr. prostatitis. as a child, I had polynephritis, which is a disease of the kidneys. So, apart from palpitations and pain in the kidneys, I couldn’t sleep, I didn’t feel anything.

    Helpful feedback? 36 Reply Show answer (1)

  • Guest

    September 20, 2016

    Levitra, Cialis, Viagra – all this is the 20th century … Together with the result they bring a whole bunch of side effects, which can be different, from a headache with an increase in blood pressure to a microstroke Levitra, Cialis, Viagra – all this is the 20th century . .. Together with the result, they bring a whole bunch of side effects that can be different, from a headache with an increase in blood pressure to microstroke

    Helpful feedback? 86 Reply Show answer (1)

  • Guest

    August 27, 2016

    After the first dose, the side effects were not big, pain in the lower back and hips. But after repeating for three days, the pain in the lower back was such that he did not sleep all night. Conclusion: not suitable for frequent use. After the first dose, the side effects were not big, pain in the lower back and hips. But after repeating for three days, the pain in the lower back was such that he did not sleep all night. Conclusion: not suitable for frequent use

    Helpful feedback? 25 Reply Show answers (2)

  • Guest

    August 25, 2016

    I drank Cialis in the morning, expected a rush of blood to my face, palpitations, etc. etc., but to my surprise nothing happened. I already thought about buying a dummy, but then on contact everything worked with a bang, 4 visits per day and the same number could be … Read review I drank Cialis in the morning, I expected a rush of blood to my face, palpitations, etc. etc., but to my surprise nothing happened. I already thought I bought a dummy, but then on contact everything worked with a bang, 4 visits per day and the same number could have been. A day later, only side effects appeared, pain in the lower back and hips, not strong but quite aching and unpleasant.

    Helpful feedback? 30 Reply

  • Anatoly

    July 30, 2016

    Cialis is an excellent drug, it is not for nothing that it is called a weekend pill. So far, this is one of the best drugs on my list, as it gives a long-term effect and there are no side effects. Cialis is an excellent drug, it is not for nothing that it is called a weekend pill. So far, this is one of the best drugs on my list, as it gives a long-term effect and there are no side effects.

    Helpful feedback? 15 Reply

  • Alex

    July 11, 2016 I didn’t feel any side effects, the main thing is not to drink alcohol, I tried generics a couple of times zero potential too, but I took Conegra Deluxe 50mm in a pharmacy full fly away the price is normal and I didn’t feel any side effects, the main thing is not to drink alcohol

    Helpful feedback? 9 Reply

  • Max

    June 22, 2016

    Good drug, less side effects than Viagra. And the duration is definitely impressive. Of course, the pill does not reach up to 36 hours, but if I drink tonight, then there is still enough for tomorrow evening. The most important thing is to find quality pills. Good drug, less side effects than Viagra. And the duration is definitely impressive. Of course, the pill does not reach up to 36 hours, but if I drink tonight, then there is still enough for tomorrow evening. The most important thing is to find quality pills.

    Helpful feedback? 19 Reply

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CIALIS prices in pharmacies

Cialis in stock found in 98 pharmacies

9 0548 951 96

9000 3

9 0548 9Eli Lilly 80

public SITE phone CALL directions Route

Cialis tab 20mg N1 719 96
Cialis tab 20mg N2
Cialis tab 20mg N4 1″> 1.715 10
Cialis tab 5mg N28 4.667 23
public SITE phone CALL directions Route

Cialis tab. po 20 mg. №2 700 00
Cialis tab. i.v. 20 mg. №4 1,200 00
public SITE phone CALL directions Route

CIALIS tab. p / captivity. shell 20 mg blister №1 Lilly Icos (Great Britain) 694 00
Cialis tab. p / captivity. shell 20 mg blister №2 Lilly Icos (UK) 1.272 00
Cialis tab. p / captivity. shell 20 mg blister №4 Lilly Icos (UK) 2.229 00
Cialis tab. p / captivity. shell 20 mg blister №8 Lilly Icos (Great Britain) 4.195 00
Cialis tab. p / captivity. shell 5 mg blister №28 Eli Lilly Netherland (Netherlands) 4.637 50
9 0057 public SITE phone CALL directions Route

Cialis 20mg №1 tablets Eli Lilly (Great Britain) 2″> 471 20
Cialis 20mg №2 tablets Eli Lilly (UK) 940 70
Cialis 20mg №4 tablets Eli Lilly (UK)
Cialis 5 mg tablets №28 Optima promo 3.742 30
public SITE phone CALL directions Route

Cialis tab. Cialis tab 20mg №2 Eli Lilly 1.044 00

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    See also

    Impotence and erectile dysfunction

      Cialis instructions

      Cialis is a preparation containing tadalafil.