Cortisone, Oral Tablet

Highlights for cortisone

1. Cortisone oral tablet is only available as a generic drug. It doesn’t have a brand-name version.
2. Cortisone only comes as a tablet you take by mouth.
3. Cortisone oral tablet is used to treat a variety of conditions. These can include adrenocortical insufficiency, arthritis, allergies, and ulcerative colitis. It’s also used to treat anemia, lupus, and skin conditions, including severe psoriasis.

• Chickenpox and measles warning: This drug can weaken your body’s ability to fight infections. Try to stay away from people who have chickenpox or measles, especially if you haven’t been vaccinated or haven’t had these diseases before. Call your doctor right away if you have contact with anyone who has these diseases while you’re taking this drug.
• Infections warning: You shouldn’t take this drug if you have an infection. These include fungal, bacterial, or viral infections. Cortisone can weaken your body’s response to infections. This means that your infection may be severe or even fatal (cause death). This drug can also cover up symptoms of infection. If you have any signs of infection, call your doctor right away.

Cortisone oral tablet is a prescription drug. It’s only available as a generic drug.

Why it’s used

Cortisone helps to decrease inflammation and immune responses. It can also be used as replacement therapy for certain hormones.

This drug is used to treat several conditions. These include:

• adrenal insufficiency
• arthritis, including osteoarthritis and rheumatoid arthritis
• allergic conditions, such as seasonal allergies
• asthma
• ulcerative colitis
• anemia
• lupus
• skin conditions, such as severe psoriasis

How it works

Cortisone belongs to a class of drugs called glucocorticoids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Cortisone is a steroid drug. It helps decrease swelling and inflammation in your body. It works by stopping the release of molecules that cause inflammation. This also stops your body from having an immune response.

Cortisone oral tablet doesn’t cause drowsiness. However, it can cause other side effects.

More common side effects

The more common side effects of cortisone can include:

• confusion
• excitement
• restlessness
• headache
• nausea
• vomiting
• skin problems, including:
  • acne
  • thin skin
  • heavy sweating
  • redness
• trouble sleeping
• weight gain

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Allergic reactions. Symptoms can include:
  • skin rash
  • itching
  • hives
  • swelling of your face, lips, or tongue
• Fluid and electrolyte problems. These can include:
  • fluid retention
  • heart failure, with symptoms such as:
    • shortness of breath
    • fast heart rate
    • swelling of your arms and legs
  • high blood pressure
• Muscle problems. Symptoms can include:
  • muscle weakness
  • broken bones in your spine
  • osteoporosis
  • tendon rupture
• Stomach problems. These can include:
  • peptic ulcer, with symptoms such as:
    • upper stomach pain
    • black, tarry stools
  • pancreatitis (inflammation of the pancreas), with symptoms such as:
    • upper stomach pain
    • nausea
    • vomiting
• Slowed growth in children
• Glaucoma. Symptoms can include:
  • blurry vision
  • double vision
  • eye pain
• Convulsions

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Cortisone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with cortisone are listed below.

Drugs you should not use with cortisone

Do not receive live vaccines while you’re taking cortisone. Examples of these drugs include:

• live flu vaccine
• measles, mumps, and rubella vaccine (MMR)

If you receive a live vaccine, your body might not be able to build up resistance to the virus in the vaccine. The virus can spread in your body and cause an infection.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Cortisone oral tablet comes with several warnings.

Allergy warning

Cortisone can cause a severe allergic reaction. Symptoms can include:

• skin rash
• itching or hives
• swelling of your face, lips, or tongue

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Warnings for people with certain health conditions

For people with infections: Don’t take this drug if you have a fungal, bacterial, or viral infection. Cortisone can weaken your body’s response to infections. This can be severe or fatal. The drug can also cover up the symptoms of an infection.

For people with high blood pressure or heart problems: This drug can raise your blood pressure. It can also make heart conditions worse.

For people with diabetes: Ask your doctor if this drug is safe for you. Cortisone can increase your blood sugar. You may need to test your blood sugar level more often. Your doctor may also change the dosage of your diabetes drugs.

For people with glaucoma or eye problems: This drug increases your risk of eye infections. Ask your doctor if this drug is safe for you.

For people with stomach or intestinal problems: This drug can irritate your stomach and intestines. This can make your condition worse. Ask your doctor if this drug is safe for you.

For people with liver problems: Ask your doctor if this drug is safe for you. It may make your liver problems worse.

For people with kidney problems: Ask your doctor if this drug is safe for you. It may make your kidney problems worse.

For people with seizures: Ask your doctor if this drug is safe for you. It may make your condition worse.

For people with psychiatric and mood disorders: Ask your doctor if this drug is safe for you. It may make your condition worse.

Warnings for other groups

For pregnant women: There has not been enough research done on the use of cortisone in pregnant women. Talk to your doctor if you’re pregnant or plan to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should only be used if the potential risk is acceptable given the drug’s potential benefit.

Call your doctor right away if you become pregnant while taking this drug.

For women who are breastfeeding: This drug may pass into breast milk and cause side effects in a child who is breastfed. These side effects include slowed growth and development. Talk to your doctor about breastfeeding your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For children: It has not been confirmed that cortisone is safe and effective for use in people younger than 18 years.

This dosage information is for cortisone oral tablet. All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Forms and strengths

Generic: Cortisone

• Form: Oral tablet
• Strengths: 25 mg

Dosage for all conditions

Adult dosage (ages 18 years and older)

• Typical dosage: 25–300 mg per day. Your doctor will decide your dosage depending on your condition.

Child dosage (ages 0–17 years)

Cortisone has not been confirmed as safe and effective for use in people younger than 18 years.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Cortisone oral tablet is used for both short-term and long-term treatment. The length of your treatment will depend on your condition. It comes with risks if you don’t take it as prescribed.

If you stop taking this drug suddenly or don’t take it at all: You may have withdrawal symptoms if you stop taking this drug suddenly. If you need to stop taking it, your doctor will slowly reduce your dosage over time.

If you don’t take this drug at all, your condition won’t be treated and may get worse.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• insomnia (trouble falling or staying asleep)
• nervousness
• increased appetite
• indigestion

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take it as soon as you remember. If it’s almost time for your next dose, call your doctor or pharmacist. You might need to miss a dose or take an extra dose depending on the condition you’re treating. Don’t take an extra dose without checking with your doctor or pharmacist.

How to tell if the drug is working: You should have fewer symptoms and decreased inflammation.

Keep these considerations in mind if your doctor prescribes cortisone oral tablet for you.

General

• Take cortisone with food and a glass of water. This may help reduce upset stomach.
• Take this drug in the morning.
• You can cut or crush the oral tablet

Storage

• Store cortisone at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
• Keep this drug away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t hurt your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

You and your doctor should monitor certain health issues during your treatment. This can help make sure you stay safe while you take this drug. These issues include:

• blood pressure levels
• blood sugar levels (if you have diabetes)
• potassium levels

Your diet

This drug may cause you to retain salt and water. It may also affect your potassium levels. Your doctor may tell you to take potassium supplements or reduce how much salt you eat.

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Cortisone, Oral Tablet

Highlights for cortisone

1. Cortisone oral tablet is only available as a generic drug. It doesn’t have a brand-name version.
2. Cortisone only comes as a tablet you take by mouth.
3. Cortisone oral tablet is used to treat a variety of conditions. These can include adrenocortical insufficiency, arthritis, allergies, and ulcerative colitis. It’s also used to treat anemia, lupus, and skin conditions, including severe psoriasis.

• Chickenpox and measles warning: This drug can weaken your body’s ability to fight infections. Try to stay away from people who have chickenpox or measles, especially if you haven’t been vaccinated or haven’t had these diseases before. Call your doctor right away if you have contact with anyone who has these diseases while you’re taking this drug.
• Infections warning: You shouldn’t take this drug if you have an infection. These include fungal, bacterial, or viral infections. Cortisone can weaken your body’s response to infections. This means that your infection may be severe or even fatal (cause death). This drug can also cover up symptoms of infection. If you have any signs of infection, call your doctor right away.

Cortisone oral tablet is a prescription drug. It’s only available as a generic drug.

Why it’s used

Cortisone helps to decrease inflammation and immune responses. It can also be used as replacement therapy for certain hormones.

This drug is used to treat several conditions. These include:

• adrenal insufficiency
• arthritis, including osteoarthritis and rheumatoid arthritis
• allergic conditions, such as seasonal allergies
• asthma
• ulcerative colitis
• anemia
• lupus
• skin conditions, such as severe psoriasis

How it works

Cortisone belongs to a class of drugs called glucocorticoids. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Cortisone is a steroid drug. It helps decrease swelling and inflammation in your body. It works by stopping the release of molecules that cause inflammation. This also stops your body from having an immune response.

Cortisone oral tablet doesn’t cause drowsiness. However, it can cause other side effects.

More common side effects

The more common side effects of cortisone can include:

• confusion
• excitement
• restlessness
• headache
• nausea
• vomiting
• skin problems, including:
  • acne
  • thin skin
  • heavy sweating
  • redness
• trouble sleeping
• weight gain

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 911 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

• Allergic reactions. Symptoms can include:
  • skin rash
  • itching
  • hives
  • swelling of your face, lips, or tongue
• Fluid and electrolyte problems. These can include:
  • fluid retention
  • heart failure, with symptoms such as:
    • shortness of breath
    • fast heart rate
    • swelling of your arms and legs
  • high blood pressure
• Muscle problems. Symptoms can include:
  • muscle weakness
  • broken bones in your spine
  • osteoporosis
  • tendon rupture
• Stomach problems. These can include:
  • peptic ulcer, with symptoms such as:
    • upper stomach pain
    • black, tarry stools
  • pancreatitis (inflammation of the pancreas), with symptoms such as:
    • upper stomach pain
    • nausea
    • vomiting
• Slowed growth in children
• Glaucoma. Symptoms can include:
  • blurry vision
  • double vision
  • eye pain
• Convulsions

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Cortisone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with cortisone are listed below.

Drugs you should not use with cortisone

Do not receive live vaccines while you’re taking cortisone. Examples of these drugs include:

• live flu vaccine
• measles, mumps, and rubella vaccine (MMR)

If you receive a live vaccine, your body might not be able to build up resistance to the virus in the vaccine. The virus can spread in your body and cause an infection.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

Cortisone oral tablet comes with several warnings.

Allergy warning

Cortisone can cause a severe allergic reaction. Symptoms can include:

• skin rash
• itching or hives
• swelling of your face, lips, or tongue

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 911 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

Warnings for people with certain health conditions

For people with infections: Don’t take this drug if you have a fungal, bacterial, or viral infection. Cortisone can weaken your body’s response to infections. This can be severe or fatal. The drug can also cover up the symptoms of an infection.

For people with high blood pressure or heart problems: This drug can raise your blood pressure. It can also make heart conditions worse.

For people with diabetes: Ask your doctor if this drug is safe for you. Cortisone can increase your blood sugar. You may need to test your blood sugar level more often. Your doctor may also change the dosage of your diabetes drugs.

For people with glaucoma or eye problems: This drug increases your risk of eye infections. Ask your doctor if this drug is safe for you.

For people with stomach or intestinal problems: This drug can irritate your stomach and intestines. This can make your condition worse. Ask your doctor if this drug is safe for you.

For people with liver problems: Ask your doctor if this drug is safe for you. It may make your liver problems worse.

For people with kidney problems: Ask your doctor if this drug is safe for you. It may make your kidney problems worse.

For people with seizures: Ask your doctor if this drug is safe for you. It may make your condition worse.

For people with psychiatric and mood disorders: Ask your doctor if this drug is safe for you. It may make your condition worse.

Warnings for other groups

For pregnant women: There has not been enough research done on the use of cortisone in pregnant women. Talk to your doctor if you’re pregnant or plan to become pregnant. Ask your doctor to tell you about the specific harm that may be done to the fetus. This drug should only be used if the potential risk is acceptable given the drug’s potential benefit.

Call your doctor right away if you become pregnant while taking this drug.

For women who are breastfeeding: This drug may pass into breast milk and cause side effects in a child who is breastfed. These side effects include slowed growth and development. Talk to your doctor about breastfeeding your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For children: It has not been confirmed that cortisone is safe and effective for use in people younger than 18 years.

This dosage information is for cortisone oral tablet. All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

• your age
• the condition being treated
• how severe your condition is
• other medical conditions you have
• how you react to the first dose

Forms and strengths

Generic: Cortisone

• Form: Oral tablet
• Strengths: 25 mg

Dosage for all conditions

Adult dosage (ages 18 years and older)

• Typical dosage: 25–300 mg per day. Your doctor will decide your dosage depending on your condition.

Child dosage (ages 0–17 years)

Cortisone has not been confirmed as safe and effective for use in people younger than 18 years.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always speak with your doctor or pharmacist about dosages that are right for you.

Cortisone oral tablet is used for both short-term and long-term treatment. The length of your treatment will depend on your condition. It comes with risks if you don’t take it as prescribed.

If you stop taking this drug suddenly or don’t take it at all: You may have withdrawal symptoms if you stop taking this drug suddenly. If you need to stop taking it, your doctor will slowly reduce your dosage over time.

If you don’t take this drug at all, your condition won’t be treated and may get worse.

If you miss doses or don’t take the drug on schedule: Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much: You could have dangerous levels of the drug in your body. Symptoms of an overdose of this drug can include:

• insomnia (trouble falling or staying asleep)
• nervousness
• increased appetite
• indigestion

If you think you’ve taken too much of this drug, call your doctor or seek guidance from the American Association of Poison Control Centers at 800-222-1222 or through their online tool. But if your symptoms are severe, call 911 or go to the nearest emergency room right away.

What to do if you miss a dose: Take it as soon as you remember. If it’s almost time for your next dose, call your doctor or pharmacist. You might need to miss a dose or take an extra dose depending on the condition you’re treating. Don’t take an extra dose without checking with your doctor or pharmacist.

How to tell if the drug is working: You should have fewer symptoms and decreased inflammation.

Keep these considerations in mind if your doctor prescribes cortisone oral tablet for you.

General

• Take cortisone with food and a glass of water. This may help reduce upset stomach.
• Take this drug in the morning.
• You can cut or crush the oral tablet

Storage

• Store cortisone at room temperature. Keep it between 68°F and 77°F (20°C and 25°C).
• Keep this drug away from light.
• Don’t store this medication in moist or damp areas, such as bathrooms.

Refills

A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

• Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
• Don’t worry about airport X-ray machines. They can’t hurt your medication.
• You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you.
• Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Clinical monitoring

You and your doctor should monitor certain health issues during your treatment. This can help make sure you stay safe while you take this drug. These issues include:

• blood pressure levels
• blood sugar levels (if you have diabetes)
• potassium levels

Your diet

This drug may cause you to retain salt and water. It may also affect your potassium levels. Your doctor may tell you to take potassium supplements or reduce how much salt you eat.

Availability

Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it.

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Cortisone :: Instructions :: Price :: Description of the drug

White or white with a slight yellowish tint crystalline powder. Practically insoluble in water, very slightly soluble in alcohol.
1 ml of suspension contains 0.025 g of cortisone acetate

Cortisone acetate is produced for use in medical practice. Influences protein and carbohydrate metabolism. It reduces the total amount of protein in plasma, mainly the globulin fraction, as a result of which the albuminoglobulin coefficient increases. It enhances the processes of catabolism (protein breakdown) in the muscles, at the same time it promotes its synthesis from decay products in the liver and kidneys, that is, it causes inhibition of protein synthesis in some tissues and accelerates its formation in others. Controls the process of deamination (cleavage) of amino acids in the liver. The catabolic and anabolic (enhancing) effect of cortisone on protein synthesis is realized through its effect on nucleic acids. The catabolic effect of the drug explains the depletion of the body in proteins and muscle atrophy (decrease in muscle mass and strength), osteoporosis (malnutrition of bone tissue, accompanied by an increase in its fragility) as a result of resorption of the protein part of the bone with an excess of glucocorticoids (hormones of the adrenal cortex that affect carbohydrate and protein metabolism). ).
In the mechanism of action of cortisone acetate, as well as other corticosteroids, a decrease in the activity of hexokinase, an enzyme involved in glucose phosphorylation, is of great importance. By activating glucose-6-phosphatase, cortisone increases the flow of glucose from the liver into the bloodstream, induces (causes) the synthesis of the key enzyme of gluconeogenesis (the process of glucose formation) – phosphoenolpyruvate carboxylase and accelerates the synthesis of some aminotransferases. This leads to an increase in the synthesis of carbohydrates from amino acids formed during protein breakdown, an increase in the glycogen content in the liver and muscles, and a decrease in glucose tolerance (tolerance). The absorption of carbohydrates in the intestine increases and their consumption by the muscles decreases.
The drug causes the disintegration of the lymphoid and inhibition of the synthesis of connective tissue, inhibits (suppresses) the synthesis of hyaluronidase, thus reducing the permeability of capillaries (tiny vessels), suppresses allergic reactions. It has an effect on fat metabolism, delaying the mobilization of fat, accelerating the synthesis of higher fatty acids and, thereby, triglycerides. Promotes sodium retention and increased excretion of potassium from the body.

Rheumatism, rheumatoid arthritis (an infectious-allergic disease from the group of collagenoses, characterized by chronic progressive inflammation of the joints) and other collagenoses (a common name for diseases characterized by diffuse damage to the connective tissue and blood vessels), bronchial asthma, acute myeloid and lymphoblastic leukemia (a malignant tumor of the blood , originating from the hematopoietic cells of the bone marrow), infectious mononucleosis (an acute viral disease that occurs with a high rise in body temperature, an increase in the palatine lymph nodes, liver), neurodermatitis (skin diseases caused by dysfunction of the central nervous system), eczema (a neuroallergic skin disease characterized by weeping, itchy inflammation) and other skin diseases, Addison’s disease (insufficient function of the adrenal glands) and acute insufficiency of the adrenal cortex, hemolytic anemia (increased breakdown of red blood cells), glomerulonephritis (kidney disease), viral hepatitis (inflammation of the liver tissue caused by a virus), acute pancreatitis (inflammation of the pancreas), collapse (a sharp drop in blood pressure) and shock of various nature (post-traumatic, anaphylactic / allergic /, cardiogenic, etc. ).

Administer orally or intramuscularly (as a suspension /suspension of drug solids in liquid/).
Inside is usually taken in the first days of treatment at 0.1-0.2 g per day (in 3-4 doses), then the dose is gradually reduced to the minimum sufficient to maintain the therapeutic effect (an average of 0.025 g per day). The course dose for rheumatism is 3-4 g. (as a suspension) – 8-12 hours
In Addison’s disease, cortisone is prescribed together with deoxycorticosterone, sodium chloride is simultaneously administered. Usually take 0.0125-0.025 g per day (12.5-25.0 mg) of cortisone, 0.001-0.005 g (1-5 mg) of deoxycorticosterone acetate and 4-6-10 g of sodium chloride. A combination of cortisone with ascorbic acid is also recommended.
Higher doses of cortisone acetate for adults: single – 0.15 g, daily – 0.3 g.
Cortisone is prescribed for children in smaller doses; however, it should be borne in mind that the amount of the drug should correspond to the severity of the disease rather than age. Young children are usually prescribed 0.0125-0.025 g 3 times a day for 2 days, then 2 times a day, then the dose is reduced to maintenance; school-age children – 0.025 g 3 times a day, then 2 times a day, then the dose is reduced to the minimum sufficient to maintain the therapeutic effect. Taken orally or injected intramuscularly.
Cortisone, like other steroid hormones, must be used under medical supervision. Patients must first carefully examine and then systematically monitor the blood picture, body weight, blood pressure, blood glucose and mental state.

Cortisone is more likely to cause side effects than other glucocorticosteroid drugs. With prolonged treatment and the use of large doses (more than 0.1 g per day), obesity, hirsutism (excessive hair growth in women, manifested by the growth of a beard, mustache, etc.), acne, menstrual irregularities, osteoporosis, Itsenko- Cushing’s disease (obesity, accompanied by a decrease in sexual function, increased bone fragility due to increased secretion of adrenocorticotropic hormone from the pituitary gland), mental disorders, etc. Ulceration of the digestive tract, perforation of an unrecognized ulcer (the occurrence of a through defect in the wall of the stomach or small intestine at the site of the ulcer), hemorrhagic pancreatitis ( inflammation of the pancreas, proceeding with hemorrhage in her body). Due to the advent of more effective, better tolerated synthetic glucocorticoid drugs, cortisone is currently of limited use.

Severe hypertension (persistent rise in blood pressure), diabetes mellitus, Itsenko-Cushing’s disease, pregnancy, stage III circulatory failure, peptic ulcer, recent surgery, syphilis, active form of tuberculosis, old age.

Tablets of 0.025 and 0.05 g; suspension in vials containing 10 ml

List B. In a place protected from light.

Cortisone Acetate, Adreson, Cortadren, Cortelan, Cortisat, Cortistab, Cortistal, Cortisil, Cortogen, Corton, Incorten, Rincorten.

cortisone acetate

The instruction was compiled by a team of authors and editors of the Piluli website. The list of authors of the drug reference book is presented on the site editorial page: Site editors.

Links to used sources of information.

Attention!
Description of the drug “ Cortisone ” on this page is a simplified and supplemented version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the annotation approved by the manufacturer.
Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide on the appointment of the drug, as well as determine the dose and methods of its use.

Cortisone pills 25mg No. 80 at a low price in Omsk, instructions for use, composition, analogues

cortisone acetate 25 mg.

Excipients:

sugar,

potato starch,

stearic acid.

Pharmacological action

GCS. It has a significant effect on carbohydrate metabolism and, to a lesser extent, on water and electrolyte metabolism. It has mineralocorticoid activity: sodium retention, potassium loss, fluid retention in the body. Promotes the accumulation of glycogen in the liver, increases the content of glucose in the blood, increases the excretion of nitrogen in the urine. It has anti-inflammatory, desensitizing and anti-allergic effects, has immunosuppressive activity.

The anti-inflammatory effect is due to the inhibition of phospholipase A2, which leads to inhibition of prostaglandin synthesis, a decrease in the release of macrophage chemotactic factor, a decrease in the migration of macrophages and lymphocytes to the site of inflammation, stabilization of lysosome membranes and prevention of the release of lysosomal enzymes.

Immunosuppressive effect is associated with a decrease in the number of immunocompetent cells, with a decrease in the binding of immunoglobulins to cell receptors, suppression of blast transformation of B-lymphocytes, a decrease in the number of interleukins, lymphokines, circulating immunocomplexes, complement fractions.

Increases the excretion of calcium in the urine, activates bone tissue lysis by indirectly increasing the amount of calcitonin, increases the activity of osteoclasts, reduces the function of osteoblasts.

Has a catabolic effect, increases the breakdown of proteins. Having a lipolytic effect, it increases the content of fatty acids in the blood. Reduces the production of ACTH by the anterior pituitary gland, which leads to suppression of activity and subsequent atrophy of the adrenal cortex.

Readings

Addison’s disease, secondary chronic insufficiency of the adrenal cortex (with hypopituitarism).

Allergic, inflammatory, infectious-allergic, autoimmune diseases.

Contraindications

For short-term use for health reasons, the only contraindication is hypersensitivity to cortisone acetate or the components of the drug.
In children during the period of growth, corticosteroids should be used only for absolute indications and under the most careful supervision of the attending physician. With caution, the drug should be prescribed for the following diseases and conditions:

• Diseases of the gastrointestinal tract – peptic ulcer of the stomach and duodenum, esophagitis, gastritis, acute or latent peptic ulcer, recently created intestinal anastomosis, ulcerative colitis with the threat of perforation or abscess formation, diverticulitis.
• Parasitic and infectious diseases of a viral, fungal or bacterial nature (currently occurring or recently transferred, including recent contact with a patient) – herpes simplex, herpes zoster (viremic phase), chicken pox, measles. amoebiasis, strongyloidiasis. systemic mycosis. active and latent tuberculosis. Use in severe infectious diseases is permissible only against the background of specific therapy.
• Pre- and post-vaccination period (8 weeks before and 2 weeks after vaccination), lymphadenitis after BCG vaccination. Immunodeficiency states (including AIDS or HIV infection).
• Diseases of the cardiovascular system, incl. recent myocardial infarction (in patients with acute and subacute myocardial infarction, the focus of necrosis may spread, slowing down the formation of scar tissue and, as a result, rupture of the heart muscle), severe chronic heart failure, arterial hypertension, hyperlipidemia.
• Endocrine diseases – diabetes mellitus (including impaired carbohydrate tolerance), thyrotoxicosis, hypothyroidism, Itsenko-Cushing’s disease, obesity (III-IV stage).
• Severe chronic renal and/or hepatic insufficiency, nephrourolithiasis. Hypoalbuminemia and conditions predisposing to its occurrence.
• Systemic osteoporosis, myasthenia gravis, acute psychosis, poliomyelitis (except for the form of bulbar encephalitis), open and closed angle glaucoma.
• Pregnancy.

Side effects

The frequency of development and severity of side effects depends on the duration of use, the size of the dose used and the ability to comply with the circadian rhythm of Cortisone administration.

From the endocrine system:

Decreased glucose tolerance, steroid diabetes mellitus or manifestation of latent diabetes mellitus, adrenal suppression, Itsenko-Cushing’s syndrome (moon face, pituitary-type obesity, hirsutism, increased blood pressure, dysmenorrhea, amenorrhea, muscular weakness, striae), delayed sexual development in children.

From the digestive system:

Nausea, vomiting, pancreatitis, steroid gastric and duodenal ulcer, erosive esophagitis, bleeding and perforation of the gastrointestinal tract, increased or decreased appetite, indigestion, flatulence, hiccups. In rare cases, an increase in the activity of hepatic transaminases and alkaline phosphatase.

From the side of the cardiovascular system:

Arrhythmias, bradycardia (up to cardiac arrest), development (in predisposed patients) or increased severity of heart failure, ECG changes characteristic of hypokalemia, increased blood pressure, hypercoagulation, thrombosis. In patients with acute and subacute myocardial infarction – the spread of necrosis, slowing down the formation of scar tissue, which can lead to rupture of the heart muscle.

From the nervous system:

Delirium, disorientation, euphoria, hallucinations, manic-depressive psychosis, Depression, paranoia, increased Intracranial pressure, nervousness or restlessness, Insomnia, Dizziness, Vertigo, cerebellar pseudotumor, headache, convulsions.

From the sensory organs:

Posterior subcapsular cataract, increased intraocular pressure with possible damage to the optic nerve, a tendency to develop secondary bacterial, fungal or viral eye infections, trophic changes in the cornea, exophthalmos.

From the side of metabolism:

Increased excretion of calcium, hypocalcemia, weight gain, negative nitrogen balance (increased protein breakdown), increased sweating.

Caused by mineralocorticoid activity – fluid and sodium retention (peripheral edema), hypernatremia, hypokalemic syndrome (hypokalemia, arrhythmia, myalgia or muscle spasm, unusual weakness and fatigue).

Musculoskeletal side:

Deceleration of growth and ossification processes in children (premature closure of the epiphyseal growth zones), osteoporosis (very rarely, pathological bone fractures, aseptic necrosis of the head of the humerus and femur), rupture of muscle tendons, steroid myopathy, decreased muscle mass (atrophy).

On the part of the skin and mucous membranes:

Delayed wound healing, petechiae, ecchymosis, thinning of the skin, hyper- or hypopigmentation, acne, striae, a tendency to develop pyoderma and candidiasis.

Allergic reactions:

Skin rash, itching, anaphylactic shock.

Others:

Development or exacerbation of infections (combined immunosuppressants and vaccination contribute to the appearance of this side effect), leukocyturia, withdrawal syndrome.

Interaction

Simultaneous administration of Cortisone with:

Inducers of hepatic microsomal enzymes (phenobarbital, rifampicin, phenytoin, theophylline, ephedrine) leads to a decrease in its concentration.

Diuretics (especially thiazide and carbonic anhydrase inhibitors) and amphotericin B may lead to increased excretion of K + from the body, with sodium-containing drugs – edema and increased blood pressure.

Amphotericin B increases the risk of heart failure.

Cardiac glycosides worsen their tolerability and increase the likelihood of developing ventricular extrasystole (due to the hypokalemia caused).

Indirect anticoagulants weakens (rarely enhances) their effect (dose adjustment is required).

Anticoagulants and thrombolytics increase the risk of bleeding from ulcers in the gastrointestinal tract.

Ethanol and non-steroidal anti-inflammatory drugs (NSAIDs) increase the risk of ulcerative lesions in the gastrointestinal tract and the development of bleeding (in combination with NSAIDs in the treatment of arthritis, it is possible to reduce the dose of glucocorticosteroids due to the summation of the therapeutic effect).

Paracetamol increases the risk of hepatotoxicity (induction of liver enzymes and the formation of a toxic metabolite of paracetamol).

Acetylsalicylic acid accelerates its excretion and reduces the concentration in the blood (with the abolition of Cortisone, the level of salicylates in the blood increases and the risk of side effects increases).

Insulin and oral hypoglycemic drugs, antihypertensive drugs reduce their effectiveness.

Vitamin D reduces its effect on Ca 2+ absorption in the intestine.

Growth hormone reduces the effectiveness of the latter, and with praziquantel – its concentration.

M-anticholinergics (including antihistamines and tricyclic antidepressants) and nitrates increase intraocular pressure.

Isoniazid and mexelitin increase their metabolism (especially in slow acetylators), resulting in a decrease in their plasma concentrations.

Carbonic anhydrase inhibitors and loop diuretics may increase the risk of osteoporosis.

Indomethacin, displacing Cortisone from its association with albumin, increases the risk of its side effects.

ACTH enhances the action of Cortisone.

Ergocalciferol and parathormone prevent the development of cortisone-induced osteopathy.

Cyclosporine and ketoconazole, by slowing down the metabolism of Cortisone, can in some cases increase its toxicity.

Simultaneous administration of androgens and anabolic steroid drugs with Cortisone contributes to the development of peripheral edema and hirsutism, the appearance of acne.

Estrogens and oral estrogen-containing contraceptives reduce the clearance of Cortisone, which may be accompanied by an increase in the severity of its action.

Mitotane and other inhibitors of adrenal function may necessitate an increase in the dose of Cortisone.

When used simultaneously with live antiviral vaccines and against the background of other types of immunization, it increases the risk of virus activation and the development of infections.

Antipsychotics (neuroleptics) and azathioprine increase the risk of developing cataracts when Cortisone is prescribed.

Simultaneous administration of antacids reduces the absorption of Cortisone.

With simultaneous use with antithyroid drugs, it decreases, and with thyroid hormones, the clearance of Cortisone increases.

How to take, course of administration and dosage

Inside.

For chronic adrenal insufficiency:

The usual average maintenance dose is 25-50 mg per day. The daily dose of the drug is prescribed in 2 doses, reproducing the daily rhythm of cortisone secretion – 2/3 of the daily dose in the morning (at 6-8 o’clock) and 1/3 of the daily dose in the evening (at 17-18 o’clock). With the threat of stress, the daily dose is increased by 2-3 times and prescribed in 3-4 doses (after 6-8 hours).

In congenital dysfunction of the adrenal cortex

Used at a dose of 25 mg per day in combination with other glucocorticosteroid drugs (prednisolone, dexamethasone).

Maximum doses for adults: single -150 mg, daily – 300 mg.

For children Cortisone is prescribed in smaller doses depending on age.

Maximum doses for children:

Up to 5 years: single – 25 mg, daily – 75 mg.

From 5 to 10 years: single – 50 mg, daily -150 mg.

Over 10 years: single dose – 75 mg, daily – 225 mg.

If it is necessary to replace Cortisone with other drugs with glucocorticosteroid activity, it should be remembered that 25 mg of cortisone is equivalent in action to 20 mg of hydrocortisone. 5 mg prednisolone or prednisone. 4 mg methylprednisolone or triamcinolone. 0.75 mg dexamethasone.

Overdose

Symptoms: increased side effects.

Treatment: symptomatic.

Special instructions

During treatment with Cortisone (especially long-term) it is necessary to observe an ophthalmologist, control blood pressure, the state of water and electrolyte balance, as well as pictures of peripheral blood and blood glucose levels.

In order to reduce side effects, antacids can be prescribed, as well as to increase the intake of K + in the body (diet, potassium preparations). Food should be rich in proteins, vitamins, with limited content of fats, carbohydrates and salt.

The effect of the drug is enhanced in patients with hypothyroidism and cirrhosis of the liver.

May exacerbate existing emotional instability or psychotic disorders. When indicating a history of psychosis, Cortisone in high doses is prescribed under the strict supervision of a physician.

In stressful situations during maintenance treatment (for example, surgery, trauma or infectious diseases), the dose of the drug should be adjusted due to an increase in the need for glucocorticosteroids.

With sudden withdrawal, especially in the case of previous use of high doses, it is possible to develop a withdrawal syndrome (anorexia, nausea, lethargy, generalized musculoskeletal pain, general weakness), as well as an exacerbation of the disease for which Cortisone was prescribed.

During treatment with Cortisone, vaccination should not be carried out due to a decrease in its effectiveness (immune response).

When prescribing for intercurrent infections, septic conditions and tuberculosis, it is necessary to simultaneously treat with bactericidal antibiotics.