What are the primary uses of Diovan. How does Diovan work to treat high blood pressure. What are the most common side effects of Diovan. How should Diovan be taken for optimal effectiveness. What precautions should be considered when using Diovan. Who should avoid taking Diovan. How does Diovan interact with other medications.

Understanding Diovan: A Powerful Medication for Hypertension

Diovan, also known by its generic name valsartan, is a widely prescribed medication primarily used to treat high blood pressure (hypertension). As an angiotensin II receptor blocker (ARB), Diovan works by relaxing blood vessels, allowing blood to flow more easily and reducing the workload on the heart. This comprehensive guide will explore the various aspects of Diovan, including its uses, proper administration, potential side effects, and important precautions.

The Mechanism of Action: How Diovan Lowers Blood Pressure

Diovan’s effectiveness in treating hypertension lies in its mechanism of action. By blocking the angiotensin II receptors, it prevents the hormone angiotensin II from constricting blood vessels. This results in vasodilation, or the widening of blood vessels, which leads to improved blood flow and reduced blood pressure.

Does Diovan have any additional benefits beyond lowering blood pressure? Indeed, studies have shown that Diovan may also help protect the kidneys in patients with type 2 diabetes and reduce the risk of cardiovascular events in certain high-risk populations.

Proper Administration: Ensuring Optimal Effectiveness of Diovan

To maximize the benefits of Diovan, it’s crucial to follow the prescribed dosage and administration guidelines. Here are some key points to remember:

• Diovan can be taken with or without food
• It’s typically prescribed once or twice daily
• The dosage is based on the patient’s medical condition, response to treatment, and in children, their weight
• For liquid formulations, use a special measuring device to ensure accurate dosing
• If using a suspension form, shake the bottle well for at least 10 seconds before each dose

How long does it take for Diovan to start working? While some patients may experience a reduction in blood pressure within a few days, it can take up to 4 weeks for the full effects of Diovan to be realized. It’s important to continue taking the medication as prescribed, even if you feel well, to maintain its blood pressure-lowering effects.

Potential Side Effects: What to Watch For When Taking Diovan

As with any medication, Diovan can cause side effects in some patients. While many people tolerate the drug well, it’s essential to be aware of potential adverse reactions:

Common Side Effects

• Dizziness or lightheadedness
• Headache
• Fatigue
• Nausea
• Abdominal pain

Serious Side Effects

While rare, some patients may experience more severe side effects that require immediate medical attention:

• Fainting
• Symptoms of high potassium levels (muscle weakness, slow/irregular heartbeat)
• Signs of kidney problems (changes in urine output)
• Severe allergic reactions (rash, itching/swelling, severe dizziness, trouble breathing)

Can Diovan cause long-term side effects? While most side effects are temporary and subside as the body adjusts to the medication, long-term use of Diovan should be monitored by a healthcare provider to ensure continued safety and efficacy.

Precautions and Contraindications: When to Avoid Diovan

Certain individuals should exercise caution or avoid using Diovan altogether. It’s crucial to inform your healthcare provider of any pre-existing conditions or medications you’re taking before starting Diovan treatment.

Contraindications

• Pregnancy: Diovan can cause serious harm to an unborn baby and should not be used during pregnancy
• Allergic reactions to valsartan or any ingredients in the medication
• Severe liver disease
• Concomitant use with aliskiren in patients with diabetes

Precautions

Special care should be taken in patients with:

• Kidney problems
• Liver disease
• Dehydration
• High potassium levels
• History of angioedema

Is it safe to drink alcohol while taking Diovan? Alcohol can enhance the blood pressure-lowering effects of Diovan, potentially leading to increased dizziness or lightheadedness. It’s advisable to limit alcohol consumption and consult with your healthcare provider about safe alcohol use while on this medication.

Drug Interactions: Navigating Potential Risks with Diovan

Diovan can interact with various medications and substances, potentially altering its effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you’re using.

Common Drug Interactions

• Potassium supplements or salt substitutes containing potassium
• Other blood pressure medications, especially ACE inhibitors or aliskiren
• Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen
• Lithium
• Certain diuretics

How can patients minimize the risk of drug interactions with Diovan? The best approach is to maintain open communication with your healthcare provider and pharmacist. Always disclose all medications and supplements you’re taking, and consult with them before starting any new treatments.

Special Populations: Considerations for Specific Patient Groups

While Diovan is generally safe and effective for many patients, certain groups require special consideration:

Elderly Patients

Older adults may be more sensitive to the effects of Diovan, particularly the blood pressure-lowering action. Careful monitoring and potential dosage adjustments may be necessary.

Pediatric Patients

Diovan can be used in children 6 years and older for hypertension. Dosing is based on weight, and the safety and efficacy in children under 6 have not been established.

Patients with Renal Impairment

While Diovan can be used to treat hypertension in patients with kidney problems, close monitoring of kidney function is essential, as the medication can rarely cause or worsen kidney issues.

Patients with Hepatic Impairment

Caution is advised in patients with mild to moderate liver disease, and Diovan is contraindicated in those with severe hepatic impairment.

Are there any alternative treatments for patients who cannot take Diovan? Yes, there are several other classes of blood pressure medications that may be suitable alternatives, including ACE inhibitors, calcium channel blockers, or beta-blockers. The choice of alternative treatment depends on the individual patient’s medical history and specific needs.

Long-Term Management: Optimizing Diovan Therapy for Chronic Hypertension

For many patients, hypertension is a chronic condition requiring long-term management. Successful treatment with Diovan often involves more than just taking the medication as prescribed. Here are some strategies for optimizing long-term therapy:

Regular Monitoring

• Schedule regular check-ups with your healthcare provider
• Monitor blood pressure at home and keep a log
• Undergo periodic blood tests to check kidney function and potassium levels

Lifestyle Modifications

Combining Diovan with healthy lifestyle changes can enhance its effectiveness:

• Maintain a healthy diet low in sodium and rich in fruits, vegetables, and whole grains
• Engage in regular physical activity
• Maintain a healthy weight
• Limit alcohol consumption
• Quit smoking
• Manage stress through relaxation techniques or counseling

How can patients ensure they’re getting the most benefit from their Diovan therapy? Consistency is key. Take the medication as prescribed, maintain open communication with your healthcare provider, and combine pharmacological treatment with lifestyle modifications for optimal results.

Emerging Research: Future Directions in Diovan Therapy

As medical research continues to advance, new insights into the use of Diovan and other ARBs are emerging. Some areas of ongoing investigation include:

Expanded Indications

Researchers are exploring the potential benefits of Diovan in treating conditions beyond hypertension, such as:

• Heart failure with preserved ejection fraction
• Diabetic nephropathy
• Cognitive decline in elderly patients

Combination Therapies

Studies are investigating the efficacy of combining Diovan with other medications to enhance its therapeutic effects or mitigate side effects.

Personalized Medicine

Ongoing research aims to identify genetic markers or other factors that may predict an individual’s response to Diovan, allowing for more tailored treatment approaches.

What potential breakthroughs in hypertension treatment might we see in the coming years? While it’s difficult to predict specific breakthroughs, the field of hypertension management is continually evolving. Future developments may include more targeted therapies, novel drug delivery systems, or innovative combinations of existing medications to improve efficacy and reduce side effects.

Patient Education: Empowering Individuals for Better Outcomes

Educating patients about their condition and treatment is crucial for achieving optimal outcomes with Diovan therapy. Here are some key points to emphasize:

Understanding Hypertension

• Explain the risks associated with untreated high blood pressure
• Discuss the importance of consistent blood pressure control
• Highlight the role of medication in managing hypertension

Medication Adherence

Encourage patients to:

• Take Diovan as prescribed, even if feeling well
• Use reminders or pill organizers to maintain consistency
• Never stop the medication abruptly without consulting a healthcare provider

Recognizing and Reporting Side Effects

Teach patients to:

• Identify common and serious side effects
• Know when and how to report adverse reactions
• Understand the importance of regular follow-ups

How can healthcare providers effectively communicate the importance of long-term adherence to Diovan therapy? Clear, patient-centered communication is key. Use visual aids, provide written materials, and encourage patients to ask questions. Regular follow-ups and positive reinforcement can also help maintain motivation and adherence over time.

Accessing Diovan: Navigating Insurance Coverage and Cost Considerations

For many patients, the cost of medications can be a significant concern. Here are some strategies for managing the financial aspects of Diovan therapy:

Insurance Coverage

• Check with your insurance provider about coverage for Diovan
• Explore options for lower copays or deductibles
• Consider switching to a generic version (valsartan) if available and appropriate

Patient Assistance Programs

Many pharmaceutical companies offer programs to help patients access medications at reduced costs. These may include:

• Discount cards or coupons
• Income-based assistance programs
• Free trial offers

Pharmacy Comparison

Prices for Diovan can vary between pharmacies. Consider:

• Comparing prices at different pharmacies
• Exploring mail-order options
• Asking about bulk purchase discounts for long-term prescriptions

Are there resources available to help patients find affordable options for Diovan? Yes, several online tools and resources can help patients compare prices and find assistance programs. Websites like GoodRx, NeedyMeds, or the Partnership for Prescription Assistance can provide valuable information on cost-saving options.

The Future of Hypertension Management: Beyond Diovan

While Diovan remains an important tool in managing hypertension, the field of cardiovascular medicine continues to evolve. Here are some exciting developments on the horizon:

Novel Drug Classes

Researchers are exploring new classes of antihypertensive medications, including:

• Dual-acting angiotensin receptor-neprilysin inhibitors (ARNIs)
• Endothelin receptor antagonists
• Soluble guanylate cyclase stimulators

Technological Advancements

Emerging technologies may revolutionize hypertension management:

• Wearable devices for continuous blood pressure monitoring
• Smartphone apps for medication reminders and tracking
• Telemedicine platforms for remote patient monitoring

Precision Medicine Approaches

The future of hypertension treatment may involve more personalized strategies:

• Genetic testing to predict drug response
• Biomarker-guided therapy selection
• Individualized lifestyle interventions based on genetic and environmental factors

How might these advancements impact the use of medications like Diovan in the future? While Diovan and other ARBs are likely to remain important treatment options, future approaches may involve more targeted therapies, combination treatments, and personalized management strategies. The goal is to improve efficacy, minimize side effects, and enhance overall patient outcomes in hypertension management.

Diovan oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor right away.

How to use Diovan

Read the Patient Information Leaflet if available from your pharmacist before you start taking valsartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well for at least 10 seconds before each dose.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Tell your doctor if you do not get better or if you get worse (for example, your blood pressure readings remain high or increase).

Side Effects

Dizziness or lightheadedness may occur as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: fainting, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat).

Although valsartan may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking valsartan. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking valsartan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, dehydration, high level of potassium in the blood.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.

Liquid products may contain sugar and/or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using valsartan. Valsartan may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. (See also Warning section.)

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Consult your pharmacist or physician.

Interactions

See also Precautions section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as sparsentan, ACE inhibitors including benazepril/lisinopril, birth control pills containing drospirenone).

Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).

Does Diovan interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting.

Do not share this medication with others.

Lifestyle changes that may help this medication work better include exercising, stopping smoking, and eating a low-cholesterol/low-fat diet. Consult your doctor for more details.

Lab and/or medical tests (such as kidney function tests, potassium levels) should be done while you are taking this medication. Keep all medical and lab appointments.

Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure, and share the results with your doctor.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store this medication at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

If you are using the suspension form of this medication, store it at room temperature for up to 30 days, or in the refrigerator for up to 75 days. Do not freeze.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Diovan 320 mg tablet

Color: dark grayish violetShape: almondImprint: DXL NVR

This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.

Diovan 160 mg tablet

Color: gray orangeShape: almondImprint: DX NVR

This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.

Diovan 80 mg tablet

Color: pale redShape: almondImprint: DV NVR

This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.

Diovan 40 mg tablet

Color: yellowShape: ovalImprint: NVR D O

This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Diovan (Valsartan) Drug / Medicine Information

NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia.

Valsartan

Consumer Medicine Information

What is in this leaflet

This leaflet answers some common questions about Diovan.

It does not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.

The information in this leaflet was last updated on the date listed on the final page.
More recent information on the medicine may be available.

You should ensure that you speak to your pharmacist or doctor to obtain the most up
to date information on the medicine. You can also download the most up to date leaflet
from www.novartis.com.au.

Those updates may contain important information about the medicine and its use of
which you should be aware.

All medicines have risks and benefits. Your doctor has weighed the risks of you taking
this medicine against the benefits they expect it will have for you.

If you have any concerns about taking this medicine, ask your doctor or pharmacist.

Keep this leaflet with the medicine.

You may need to read it again.

What Diovan is used for

Diovan belongs to a group of medicines called angiotensin II receptor antagonists
(AIIRAs).

Hypertension

Diovan is used to control high blood pressure, also called hypertension. Everyone
has blood pressure. This pressure helps get your blood around your body. Your blood
pressure may be different at different times of the day, depending on how busy or
worried you are. You have hypertension when your blood pressure stays higher than
is needed, even when you are calm and relaxed.

There are usually no symptoms of hypertension. The only way of knowing that you have
it is to have your blood pressure checked regularly.

High blood pressure increases the workload of the heart and blood vessels. If it continues
for a long time, it can damage the blood vessels in the brain, heart and kidneys.
This can lead to stroke, heart failure or kidney failure. High blood pressure increases
the risk of heart attacks. Lowering your blood pressure reduces the chance of these
disorders happening.

Heart Failure

Diovan is used to treat heart failure.

Heart failure means that the heart muscle cannot pump blood strongly enough to supply
all the blood needed throughout the body. Heart failure is not the same as heart attack
and does not mean that the heart stops. Diovan helps the heart to function better
and relieves some of the symptoms of heart failure.

Heart Attack

Diovan is also used to treat people after they have had a heart attack (myocardial
infarction) to reduce the risk of further heart damage and reduce further heart problems.

Ask your doctor if you have any questions about why this medicine has been prescribed
for you.

Your doctor may have prescribed it for another purpose.

There is not enough information to recommend the use of Diovan in children (below
18 years of age).

This medicine is only available with a doctor’s prescription. It is not habit-forming.

Before you take Diovan

When you must not take it

Do not take Diovan if you have ever had an allergic reaction after taking:

valsartan (the active ingredient in Diovan)

any of the other ingredients listed at the end of this leaflet

Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty
breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching
or hives on the skin.

Do not take Diovan if you are pregnant or intend to become pregnant.

Diovan is not recommended for use in pregnancy. Like other similar medicines, it could
affect your unborn baby.

Do not take Diovan if you have liver disease caused by a blockage in the bile duct
or any other severe liver disease.

Diovan is not recommended if you have these conditions.

Do not take Diovan if you are also taking other blood pressure lowering medicines
containing aliskiren and have type 2 diabetes.

Do not take Diovan after the expiry date printed on the pack or if the packaging is
torn or shows signs of tampering.

In that case, return it to your pharmacist for disposal.

Before you start to take it

Tell your doctor if you have any of the following health problems/medical conditions:

heart disease or high blood pressure that is being treated with large doses of diuretics
(also called water or fluid tablets), or being treated with beta-blockers, aliskiren
and/or ACE-inhibitors

high blood pressure due to narrowing of the arteries in the kidney

any other kidney problems or are having dialysis

milder forms of liver disease

swelling, mainly of the face and throat, while taking other medicines (including an
ACE inhibitor or aliskiren)

you have recently had severe vomiting or diarrhoea

you are severely limiting your salt intake

primary hyperaldosteronism (Conn’s syndrome), a hormone disorder causing fluid retention

obstructed blood flow through the heart from narrowing of valves (stenosis) or enlarged
septum of the heart (HOCM)

Your doctor may want to take special precautions if you have any of the above conditions.

Tell your doctor if you are breast-feeding. Ask your doctor about the risks and benefits
of taking Diovan in this case.

It is not known if valsartan, the active ingredient of Diovan, passes into the breast
milk and could affect your baby.

Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.

Your doctor will want to know if you are prone to allergies.

If you have not told your doctor about any of these things, tell them before you take
Diovan.

Taking other medicines

Tell your doctor or pharmacist if you are taking any other medicines, including medicines
that you buy without a prescription from a pharmacy, supermarket or health food shop.

Other medicines may be affected by Diovan or they may affect how well Diovan works.
You may need to take different amounts of your medicines or you may need to take different
medicines.

These medicines include:

beta-blockers, which are medicines used to treat hypertension or other heart conditions

ACE-inhibitors or aliskiren, which are also medicines used to treat hypertension or
other heart conditions

some diuretics (water or fluid pills)

potassium supplements (e.g. Slow-K^®) or other drugs that may increase potassium levels

salt substitutes containing potassium

lithium (a medicine used to treat some types of psychiatric illness)

some antibiotics (rifamycins), anti-rejection drugs (cyclosporin), antiretrovirals
(ritonavir) which may increase the effect of Diovan

anti-inflammatory medicines such as Celebrex, Voltaren and Indocid (NSAIDs) or Selective
Cyclooxygenase-2 Inhibitors (Cox-2 Inhibitors).

trimethoprim containing medicines

Your doctor may also check your kidney function.

Your doctor and pharmacist have a more complete list of medicines to be careful of
while taking Diovan.

How to take Diovan

Follow carefully all directions given to you by your doctor and pharmacist.

These instructions may differ from the information contained in this leaflet.

If you do not understand the instructions on the label, ask your doctor or pharmacist
for help.

How much to take

For hypertension, the usual dose is one 80 mg tablet once a day. If your blood pressure
is still too high after 4 weeks, your doctor may increase the dose to 160 mg once
a day, or from 160 mg to 320 mg once a day. If your blood pressure is still too high,
your doctor may add a different type of blood pressure lowering medicine.

For heart failure the usual starting dose is 40 mg twice daily. Your doctor may increase
the dose gradually up to one 160 mg tablet twice daily.

Following a heart attack, treatment is generally started at a dose of 20 mg (half
a 40 mg tablet) twice daily. Your doctor may increase the dose gradually up to 160
mg twice daily.

When to take it

When you take the first tablet from the pack of Diovan, take the one marked with the
correct day of the week (e.g. if it is Wednesday, take the tablet marked Wednesday).

Diovan comes in a calendar pack with the days of the week marked on it to help you
remember to take your tablet each day.

Take it at the same time each day.

This also helps you remember to take it, especially if you take it as part of your
usual routine (e.g. at breakfast time).

How to take it

Swallow the tablet with a full glass of water. Always take it in the same way in relation
to food.

It does not matter if you take it after food or on an empty stomach, as long as you
take it the same way each day.

If your stomach is upset after taking Diovan, always take it after a meal (e. g. breakfast).

How long to take it

Take this medicine until your doctor tells you to stop even if you feel quite well.

It will take at least 4 weeks for this medicine to have its full effect. After that,
it will be continued for as long as your doctor thinks it is needed.

If you forget to take it

If it is almost time for your next dose, skip the missed dose and take the next one
when you are meant to.

Otherwise, take the dose as soon as you remember and then go back to taking it as
you would normally.

Do not take a double dose to make up for the one that you missed.

This may increase the chance of you getting unwanted side effects.

If you have trouble remembering when to take your medicine, ask your pharmacist for
some hints.

If you take too much (Overdose)

Immediately telephone your doctor or the Poisons Information Centre (telephone number:
13 11 26) for advice, or go to Accident and Emergency at your nearest hospital if
you think that you or anyone else may have taken too much Diovan. Do this even if
there are no signs of discomfort or poisoning.

Keep the telephone numbers for these places handy.

Too much Diovan may make you feel dizzy, lightheaded or faint. You may experience
rapid, shallow breathing or cold, clammy skin. Your heartbeat may be faster than usual.
This is because your blood pressure is too low.

While you are taking Diovan

Things you must do

If you become pregnant while taking Diovan, tell your doctor immediately.

You should not take this medicine while you are pregnant.

Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.

Otherwise your doctor may think that it was not effective and change your treatment
unnecessarily.

Be sure to keep all of your doctor’s appointments so that your progress can be checked.
Do this even if you feel well.

It is important to keep track of your progress. Your doctor will want to check your
blood pressure and your kidney and liver function from time to time.

If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking Diovan.

Tell any other doctor, dentist or pharmacist who treats you that you are taking Diovan.

Things you must not do

Do not use Diovan to treat any other complaints unless your doctor says you can.

Do not give this medicine to anyone else, even if their condition seems to be similar
to yours.

Things to be careful of

Be careful driving, operating machinery or doing jobs that require you to be alert
while you are taking Diovan until you know how it affects you.

This medicine can cause tiredness, sleepiness or dizziness in some people. If you
have these symptoms, do not drive or do anything else that could be dangerous.

If this medicine makes you feel dizzy or light-headed, be careful when getting up
from a sitting or lying position.

Dizziness can usually be prevented by getting up slowly and flexing leg muscles and
toes to get the blood flowing. When getting out of bed, dangle your legs over the
side for a minute or two before standing up.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking Diovan, even if you do not think it is connected with the medicine.

All medicines can have side effects. Sometimes they are serious, but most of the time
they are not. You may need medical treatment if you get some of the side effects.

Do not be alarmed by this list of possible side effects. You may not experience any
of them.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of these side effects and they worry you:

headache

dizziness, spinning sensation (vertigo)

sleepiness, tiredness or weakness

diarrhoea, constipation or wind

nausea (feeling sick), vomiting, loss of appetite, stomach pains or indigestion

dry cough, sore throat or hoarse voice

blistering skin

runny nose or congested sinuses

pain in the back or joints

muscle pain or cramps

difficulty sleeping

feeling anxious

tingling or numbness in the hands or feet

problems with sexual function

Tell your doctor immediately or go to Accident and Emergency at your nearest hospital
if you notice any of the following:

signs of allergy such as rash, itching or hives on the skin; swelling of the face,
lips, tongue or other part of the body; fever, shortness of breath, wheezing or troubled
breathing

feeling of fast or irregular heart beat (pounding, racing, skipping beats)

chest pain

shortness of breath not caused by exercise, with swelling of legs or feet

tiredness or lack of energy, being short of breath when exercising, dizziness and
looking pale

constant “flu-like” symptoms such as chills, fever, sore throat, aching joints, sores
in mouth, swollen glands

severe dizziness or fainting

liver disease with nausea, vomiting, loss of appetite, feeling generally unwell, fever,
itching, yellowing of the skin and eyes, and dark coloured urine

The above side effects may be serious. You may need urgent medical attention.

Tell your doctor if you notice anything else that is making you feel unwell.

Other side effects not listed above may also occur in some people.

After using Diovan

Storage

Keep your tablets in the original container until it is time to take them.

Store them in a cool dry place (room temperature).

Do not store Diovan or any other medicine in the bathroom or near a sink.

Do not leave it in the car or on window sills.

Heat and dampness can destroy some medicines. Diovan will keep well if it is cool
and dry.

Keep the medicines where children cannot reach them.

A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.

Disposal

If your doctor tells you to stop taking Diovan, or the tablets have passed their expiry
date, ask your pharmacist what to do with any that are left over.

Product description

What it looks like

Diovan tablets are supplied in blister packs of 28.

Diovan 40 mg tablets are oval and yellow marked with “DO” on one side and “NVR” on
the other.

Diovan 80 mg tablets are round and pale red with a “D” and “V” marked on one side
of the tablet and “NVR on the other.

Diovan 160 mg tablets are oval shaped, and grey-orange in colour. They have the letters
“DX/DX” marked on one side of the tablet and “NVR” on the other.

Diovan 320 mg tablets are oval shaped, and grey-violet in colour. They have the letters
“DXL” marked on one side of the tablet and “NVR” on the other.

Ingredients

Diovan tablets contain 40 mg, 80 mg, 160 mg or 320 mg of valsartan as the active ingredient. 

The tablets contain the following non active ingredients:

cellulose microcrystalline

crospovidone

silica – colloidal anhydrous

magnesium stearate

hypromellose

titanium dioxide

macrogol 8000

iron oxide red CI77491

iron oxide yellow CI77492

The 40 mg, 160 mg and 320 mg tablets also contain:

iron oxide black CI77499

Diovan tablets and capsules do not contain glucose, lactose, sucrose, saccharin, gluten,
tartrazine or other azo dyes.

Sponsor

Diovan is supplied in Australia by:

NOVARTIS Pharmaceuticals

Australia Pty Limited

ABN 18 004 244 160

54 Waterloo Road

North Ryde NSW 2113

Telephone: 1 800 671 203

^®= Registered Trademark

This leaflet was prepared in February 2015.

Australian Registration Numbers:

Diovan 40 mg tabs AUST R 93165

Diovan 80 mg tabs AUST R 80868

Diovan 160 mg tabs AUST R 80871

Diovan 320 mg tabs AUST R 123357

For internal use only:

(CMI dvn140220c is based on PI dvn140220i)

Diovan instructions for use: indications, contraindications, side effects – description Diovan tab., cover. shell, 80 mg: 14, 28, 56 or 98 pcs. (260)

💊 Composition of Diovan ® ✅ Application of Diovan ® Keep it for yourself Look for alternatives Interaction Description of the active ingredients of the preparation Diovan ® (Diovan ® ) The scientific information provided is general and cannot be used to make decisions. decisions about the use of a particular drug. Update date: 2020.03.25 Marketing authorization holder: NOVARTIS PHARMA, AG (Switzerland) Manufactured: NOVARTIS PHARMA STEIN, AG (Switzerland) ATX code: C09CA03 (Valsartan) Active substance: valsartan (valsartan) Rec.INN WHO registered Dosage form Diovan ® Tab. , coated shell, 80 mg: 14, 28, 56 or 98 pcs. reg. No.: P N013991/01 dated 13.11.09 – Indefinitely Date of re-registration: 16.02.16 Release form, packaging and composition Diovan ® Tablets, film-coated pale pink, round, with beveled edges, scored on one side and embossed with “D/V”, on the other side with “NVR”. Excipients : microcrystalline cellulose, crospovidone, anhydrous colloidal silicon dioxide, magnesium stearate, hypromellose (hydroxypropyl methylcellulose), macrogol 8000, titanium dioxide (E171), iron oxide red (E172), iron oxide yellow (E172). 14 pcs. – blisters (1) – packs of cardboard. 14 pcs. – blisters (2) – packs of cardboard. 14 pcs. – blisters (4) – packs of cardboard. 14 pcs. – blisters (7) – packs of cardboard. Clinical and pharmacological group: Angiotensin II receptor antagonist Pharmacotherapeutic group: Angiotensin II receptor antagonist Pharmacological action Antihypertensive agent. It is a specific angiotensin II receptor antagonist. It has a selective antagonistic effect on AT 1 – receptors that are responsible for the implementation of the effects of angiotensin II. Due to the blockade of AT 1 receptors, the plasma concentration of angiotensin II increases, which can stimulate unblocked AT 2 receptors. Does not have agonistic activity against AT 1 receptors. The affinity of valsartan for the AT 1 receptor is approximately 20,000 times higher than for the AT 2 receptor. Does not inhibit ACE. Does not interact with or block other hormone receptors or ion channels that are important for the regulation of the functions of the cardiovascular system. Does not affect the level of total cholesterol, TG, glucose and uric acid in plasma. The onset of the antihypertensive effect of valsartan after oral administration in a single dose is observed within 2 hours after administration, the maximum effect is achieved within 4-6 hours. Absolute bioavailability averages 23%. The pharmacokinetic curve of valsartan has a multi-exponential character (T 1/2 in the α-phase < 1 h and T 1/2 in the β-phase – about 9 h), the kinetics is linear. There were no changes in pharmacokinetic parameters during the course application. When taking valsartan with food, AUC decreases by 48%, while approximately 8 hours after taking valsartan plasma concentrations are the same in patients who took it with food and on an empty stomach. The decrease in AUC is not accompanied by a clinically significant decrease in the therapeutic effect. When taking valsartan 1 time / day, cumulation is slightly pronounced. Plasma concentrations of valsartan in women and men were the same. Plasma protein binding, predominantly to albumin, is 94-97%. V d in the equilibrium state is about 17 liters. Plasma clearance of valsartan is about 2 l/h. Excreted with feces – 70% and with urine – 30%, mainly unchanged. In biliary cirrhosis or obstruction of the biliary tract, the AUC of valsartan increases by approximately 2 times. Indications of the active substances of the drug Diovan ® Treatment of arterial hypertension. Treatment of chronic heart failure (NYHA functional class II-IV) in patients receiving conventional therapy with diuretics, digitalis preparations, and ACE inhibitors or beta-blockers. Open list of ICD-10 codes I10 Essential [primary] hypertension I50. 0 Congestive heart failure Dosing regimen The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed. Take orally at a dose of 80 mg 1 time / day or 40 mg 2 times / day, daily. In the absence of an adequate effect, the daily dose may be gradually increased. The maximum daily dose of is 320 mg in 2 divided doses. Side effects From the side of the cardiovascular system: arterial hypotension, postural dizziness, postural hypotension. From the side of the central nervous system: dizziness, headache. From the digestive system: diarrhea, nausea, increased bilirubin levels. From the urinary system: rarely – impaired renal function, increased levels of creatinine and urea nitrogen (especially in chronic heart failure). From the side of metabolism: hyperkalemia. From the side of the hematopoietic system: neutropenia, decrease in hemoglobin and hematocrit. Allergic reactions: rarely – angioedema, rash, itching, serum sickness, vasculitis. Other: fatigue, general weakness, cough, pharyngitis, increased risk of viral infections. Contraindications for use Pregnancy, hypersensitivity to valsartan. Use in pregnancy and lactation Valsartan is contraindicated in pregnancy. It is not known whether valsartan is excreted in human breast milk. Use during lactation (breastfeeding) is not recommended. In experimental studies valsartan has been shown to be excreted in breast milk in rats. Use in impaired renal function In patients with renovascular hypertension secondary to renal artery stenosis, serum urea and creatinine levels should be monitored regularly during treatment. Data on the safety of use in patients with CC less than 10 ml / min are not available. Due to inhibition of the RAAS in predisposed patients, changes in renal function are possible. Use in children The safety and efficacy of valsartan in children has not been established. Special instructions With hyponatremia and / or a decrease in BCC, as well as during therapy with high doses of diuretics, in rare cases, valsartan can cause severe arterial hypotension. Before starting treatment, correction of water-salt metabolism disorders should be carried out. In patients with renovascular hypertension secondary to renal artery stenosis, serum urea and creatinine levels should be regularly monitored during treatment. Data on the safety of use in patients with CC less than 10 ml / min are not available. Use with extreme caution in patients with biliary obstruction. Due to inhibition of the RAAS in predisposed patients, changes in renal function are possible. When using ACE inhibitors and angiotensin receptor antagonists in patients with severe chronic heart failure, oliguria and / or an increase in azotemia were observed, and acute renal failure with a risk of death rarely developed. The safety and efficacy of valsartan in children has not been established. Influence on the ability to drive vehicles and mechanisms When using valsartan, it is recommended to be careful when driving a car and operating mechanisms. Drug interactions With the simultaneous use of diuretics in high doses, arterial hypotension may develop. With the simultaneous use of potassium-sparing diuretics, heparin, dietary supplements or salt substitutes containing potassium, hyperkalemia may develop. Co-administration with indomethacin may reduce the antihypertensive effect of valsartan. When used simultaneously with lithium carbonate, a case of lithium intoxication has been described. Keep If you want to place a link to the description of this drug – use this code Diovan ® . Description of the drug in the reference book Vidal.

Ministry of Antimonopoly Regulation and Trade of the Republic of Belarus