Diovan capsules: Diovan oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Diovan oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Warnings:
This drug can cause serious (possibly fatal) harm to an unborn baby if used during pregnancy. It is important to prevent pregnancy while taking this medication. Consult your doctor for more details and to discuss the use of reliable forms of birth control while taking this medication. If you are planning pregnancy, become pregnant, or think you may be pregnant, contact your doctor right away.
How to use Diovan
Read the Patient Information Leaflet if available from your pharmacist before you start taking valsartan and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once or twice daily. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight.
If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon.
Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well for at least 10 seconds before each dose.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day. Keep taking this medication even if you feel well. Most people with high blood pressure do not feel sick.
Tell your doctor if you do not get better or if you get worse (for example, your blood pressure readings remain high or increase).
Side Effects
Dizziness or lightheadedness may occur as your body adjusts to the medication. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects.
Many people using this medication do not have serious side effects.
Tell your doctor right away if you have any serious side effects, including: fainting, symptoms of a high potassium blood level (such as muscle weakness, slow/irregular heartbeat).
Although valsartan may be used to prevent kidney problems or treat people who have kidney problems, it may also rarely cause serious kidney problems or make them worse. Your doctor will check your kidney function while you are taking valsartan. Tell your doctor right away if you have any signs of kidney problems such as a change in the amount of urine.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before taking valsartan, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, dehydration, high level of potassium in the blood.
This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).
This medication may increase your potassium levels. Before using potassium supplements or salt substitutes that contain potassium, consult your doctor or pharmacist.
Liquid products may contain sugar and/or aspartame. Caution is advised if you have diabetes, phenylketonuria (PKU), or any other condition that requires you to limit/avoid these substances in your diet.
Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).
Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while using valsartan. Valsartan may harm an unborn baby. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. (See also Warning section.)
It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.
Consult your pharmacist or physician.
Interactions
See also Precautions section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Some products that may interact with this drug include: aliskiren, lithium, drugs that may increase the level of potassium in the blood (such as sparsentan, ACE inhibitors including benazepril/lisinopril, birth control pills containing drospirenone).
Some products have ingredients that could raise your blood pressure or worsen your heart failure. Tell your pharmacist what products you are using, and ask how to use them safely (especially cough-and-cold products, diet aids, or NSAIDs such as ibuprofen/naproxen).
Does Diovan interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911.
Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe dizziness, fainting.
Do not share this medication with others.
Lifestyle changes that may help this medication work better include exercising, stopping smoking, and eating a low-cholesterol/low-fat diet. Consult your doctor for more details.
Lab and/or medical tests (such as kidney function tests, potassium levels) should be done while you are taking this medication. Keep all medical and lab appointments.
Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure, and share the results with your doctor.
If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.
Store this medication at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
If you are using the suspension form of this medication, store it at room temperature for up to 30 days, or in the refrigerator for up to 75 days. Do not freeze.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Images
Diovan 320 mg tablet
Color: dark grayish violetShape: almondImprint: DXL NVR
This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.
Diovan 160 mg tablet
Color: gray orangeShape: almondImprint: DX NVR
This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.
Diovan 80 mg tablet
Color: pale redShape: almondImprint: DV NVR
This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.
Diovan 40 mg tablet
Color: yellowShape: ovalImprint: NVR D O
This medicine is a dark grayish violet, almond, tablet imprinted with “DXL” and “NVR”.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Diovan (Valsartan) Drug / Medicine Information
NOTICE: This Consumer Medicine Information (CMI) is intended for persons living in Australia.
Valsartan
Consumer Medicine Information
What is in this leaflet
This leaflet answers some common questions about Diovan.
It does not contain all the available information. It does not take the place of talking
to your doctor or pharmacist.
The information in this leaflet was last updated on the date listed on the final page.
More recent information on the medicine may be available.
You should ensure that you speak to your pharmacist or doctor to obtain the most up
to date information on the medicine. You can also download the most up to date leaflet
from www.novartis.com.au.
Those updates may contain important information about the medicine and its use of
which you should be aware.
All medicines have risks and benefits.
Your doctor has weighed the risks of you taking
this medicine against the benefits they expect it will have for you.
If you have any concerns about taking this medicine, ask your doctor or pharmacist.
Keep this leaflet with the medicine.
You may need to read it again.
What Diovan is used for
Diovan belongs to a group of medicines called angiotensin II receptor antagonists
(AIIRAs).
Hypertension
Diovan is used to control high blood pressure, also called hypertension. Everyone
has blood pressure. This pressure helps get your blood around your body. Your blood
pressure may be different at different times of the day, depending on how busy or
worried you are. You have hypertension when your blood pressure stays higher than
is needed, even when you are calm and relaxed.
There are usually no symptoms of hypertension. The only way of knowing that you have
it is to have your blood pressure checked regularly.
High blood pressure increases the workload of the heart and blood vessels. If it continues
for a long time, it can damage the blood vessels in the brain, heart and kidneys.
This can lead to stroke, heart failure or kidney failure. High blood pressure increases
the risk of heart attacks. Lowering your blood pressure reduces the chance of these
disorders happening.
Heart Failure
Diovan is used to treat heart failure.
Heart failure means that the heart muscle cannot pump blood strongly enough to supply
all the blood needed throughout the body. Heart failure is not the same as heart attack
and does not mean that the heart stops. Diovan helps the heart to function better
and relieves some of the symptoms of heart failure.
Heart Attack
Diovan is also used to treat people after they have had a heart attack (myocardial
infarction) to reduce the risk of further heart damage and reduce further heart problems.
Ask your doctor if you have any questions about why this medicine has been prescribed
for you.
Your doctor may have prescribed it for another purpose.
There is not enough information to recommend the use of Diovan in children (below
18 years of age).
This medicine is only available with a doctor’s prescription. It is not habit-forming.
Before you take Diovan
When you must not take it
Do not take Diovan if you have ever had an allergic reaction after taking:
valsartan (the active ingredient in Diovan)
any of the other ingredients listed at the end of this leaflet
Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty
breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching
or hives on the skin.
Do not take Diovan if you are pregnant or intend to become pregnant.
Diovan is not recommended for use in pregnancy.
Like other similar medicines, it could
affect your unborn baby.
Do not take Diovan if you have liver disease caused by a blockage in the bile duct
or any other severe liver disease.
Diovan is not recommended if you have these conditions.
Do not take Diovan if you are also taking other blood pressure lowering medicines
containing aliskiren and have type 2 diabetes.
Do not take Diovan after the expiry date printed on the pack or if the packaging is
torn or shows signs of tampering.
In that case, return it to your pharmacist for disposal.
Before you start to take it
Tell your doctor if you have any of the following health problems/medical conditions:
heart disease or high blood pressure that is being treated with large doses of diuretics
(also called water or fluid tablets), or being treated with beta-blockers, aliskiren
and/or ACE-inhibitors
high blood pressure due to narrowing of the arteries in the kidney
any other kidney problems or are having dialysis
milder forms of liver disease
swelling, mainly of the face and throat, while taking other medicines (including an
ACE inhibitor or aliskiren)
you have recently had severe vomiting or diarrhoea
you are severely limiting your salt intake
primary hyperaldosteronism (Conn’s syndrome), a hormone disorder causing fluid retention
obstructed blood flow through the heart from narrowing of valves (stenosis) or enlarged
septum of the heart (HOCM)
Your doctor may want to take special precautions if you have any of the above conditions.
Tell your doctor if you are breast-feeding. Ask your doctor about the risks and benefits
of taking Diovan in this case.
It is not known if valsartan, the active ingredient of Diovan, passes into the breast
milk and could affect your baby.
Tell your doctor if you are allergic to any other medicines, foods, dyes or preservatives.
Your doctor will want to know if you are prone to allergies.
If you have not told your doctor about any of these things, tell them before you take
Diovan.
Taking other medicines
Tell your doctor or pharmacist if you are taking any other medicines, including medicines
that you buy without a prescription from a pharmacy, supermarket or health food shop.
Other medicines may be affected by Diovan or they may affect how well Diovan works.
You may need to take different amounts of your medicines or you may need to take different
medicines.
These medicines include:
beta-blockers, which are medicines used to treat hypertension or other heart conditions
ACE-inhibitors or aliskiren, which are also medicines used to treat hypertension or
other heart conditions
some diuretics (water or fluid pills)
potassium supplements (e.g. Slow-K®) or other drugs that may increase potassium levels
salt substitutes containing potassium
lithium (a medicine used to treat some types of psychiatric illness)
some antibiotics (rifamycins), anti-rejection drugs (cyclosporin), antiretrovirals
(ritonavir) which may increase the effect of Diovan
anti-inflammatory medicines such as Celebrex, Voltaren and Indocid (NSAIDs) or Selective
Cyclooxygenase-2 Inhibitors (Cox-2 Inhibitors).
trimethoprim containing medicines
Your doctor may also check your kidney function.
Your doctor and pharmacist have a more complete list of medicines to be careful of
while taking Diovan.
How to take Diovan
Follow carefully all directions given to you by your doctor and pharmacist.
These instructions may differ from the information contained in this leaflet.
If you do not understand the instructions on the label, ask your doctor or pharmacist
for help.
How much to take
For hypertension, the usual dose is one 80 mg tablet once a day. If your blood pressure
is still too high after 4 weeks, your doctor may increase the dose to 160 mg once
a day, or from 160 mg to 320 mg once a day. If your blood pressure is still too high,
your doctor may add a different type of blood pressure lowering medicine.
For heart failure the usual starting dose is 40 mg twice daily. Your doctor may increase
the dose gradually up to one 160 mg tablet twice daily.
Following a heart attack, treatment is generally started at a dose of 20 mg (half
a 40 mg tablet) twice daily.
Your doctor may increase the dose gradually up to 160
mg twice daily.
When to take it
When you take the first tablet from the pack of Diovan, take the one marked with the
correct day of the week (e.g. if it is Wednesday, take the tablet marked Wednesday).
Diovan comes in a calendar pack with the days of the week marked on it to help you
remember to take your tablet each day.
Take it at the same time each day.
This also helps you remember to take it, especially if you take it as part of your
usual routine (e.g. at breakfast time).
How to take it
Swallow the tablet with a full glass of water. Always take it in the same way in relation
to food.
It does not matter if you take it after food or on an empty stomach, as long as you
take it the same way each day.
If your stomach is upset after taking Diovan, always take it after a meal (e.
g. breakfast).
How long to take it
Take this medicine until your doctor tells you to stop even if you feel quite well.
It will take at least 4 weeks for this medicine to have its full effect. After that,
it will be continued for as long as your doctor thinks it is needed.
If you forget to take it
If it is almost time for your next dose, skip the missed dose and take the next one
when you are meant to.
Otherwise, take the dose as soon as you remember and then go back to taking it as
you would normally.
Do not take a double dose to make up for the one that you missed.
This may increase the chance of you getting unwanted side effects.
If you have trouble remembering when to take your medicine, ask your pharmacist for
some hints.
If you take too much (Overdose)
Immediately telephone your doctor or the Poisons Information Centre (telephone number:
13 11 26) for advice, or go to Accident and Emergency at your nearest hospital if
you think that you or anyone else may have taken too much Diovan.
Do this even if
there are no signs of discomfort or poisoning.
Keep the telephone numbers for these places handy.
Too much Diovan may make you feel dizzy, lightheaded or faint. You may experience
rapid, shallow breathing or cold, clammy skin. Your heartbeat may be faster than usual.
This is because your blood pressure is too low.
While you are taking Diovan
Things you must do
If you become pregnant while taking Diovan, tell your doctor immediately.
You should not take this medicine while you are pregnant.
Tell your doctor if, for any reason, you have not taken your medicine exactly as prescribed.
Otherwise your doctor may think that it was not effective and change your treatment
unnecessarily.
Be sure to keep all of your doctor’s appointments so that your progress can be checked.
Do this even if you feel well.
It is important to keep track of your progress.
Your doctor will want to check your
blood pressure and your kidney and liver function from time to time.
If you are about to be started on any new medicine, remind your doctor and pharmacist
that you are taking Diovan.
Tell any other doctor, dentist or pharmacist who treats you that you are taking Diovan.
Things you must not do
Do not use Diovan to treat any other complaints unless your doctor says you can.
Do not give this medicine to anyone else, even if their condition seems to be similar
to yours.
Things to be careful of
Be careful driving, operating machinery or doing jobs that require you to be alert
while you are taking Diovan until you know how it affects you.
This medicine can cause tiredness, sleepiness or dizziness in some people. If you
have these symptoms, do not drive or do anything else that could be dangerous.
If this medicine makes you feel dizzy or light-headed, be careful when getting up
from a sitting or lying position.
Dizziness can usually be prevented by getting up slowly and flexing leg muscles and
toes to get the blood flowing. When getting out of bed, dangle your legs over the
side for a minute or two before standing up.
Side effects
Tell your doctor or pharmacist as soon as possible if you do not feel well while you
are taking Diovan, even if you do not think it is connected with the medicine.
All medicines can have side effects. Sometimes they are serious, but most of the time
they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by this list of possible side effects. You may not experience any
of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor if you notice any of these side effects and they worry you:
headache
dizziness, spinning sensation (vertigo)
sleepiness, tiredness or weakness
diarrhoea, constipation or wind
nausea (feeling sick), vomiting, loss of appetite, stomach pains or indigestion
dry cough, sore throat or hoarse voice
blistering skin
runny nose or congested sinuses
pain in the back or joints
muscle pain or cramps
difficulty sleeping
feeling anxious
tingling or numbness in the hands or feet
problems with sexual function
Tell your doctor immediately or go to Accident and Emergency at your nearest hospital
if you notice any of the following:
signs of allergy such as rash, itching or hives on the skin; swelling of the face,
lips, tongue or other part of the body; fever, shortness of breath, wheezing or troubled
breathing
feeling of fast or irregular heart beat (pounding, racing, skipping beats)
chest pain
shortness of breath not caused by exercise, with swelling of legs or feet
tiredness or lack of energy, being short of breath when exercising, dizziness and
looking pale
constant “flu-like” symptoms such as chills, fever, sore throat, aching joints, sores
in mouth, swollen glands
severe dizziness or fainting
liver disease with nausea, vomiting, loss of appetite, feeling generally unwell, fever,
itching, yellowing of the skin and eyes, and dark coloured urine
The above side effects may be serious.
You may need urgent medical attention.
Tell your doctor if you notice anything else that is making you feel unwell.
Other side effects not listed above may also occur in some people.
After using Diovan
Storage
Keep your tablets in the original container until it is time to take them.
Store them in a cool dry place (room temperature).
Do not store Diovan or any other medicine in the bathroom or near a sink.
Do not leave it in the car or on window sills.
Heat and dampness can destroy some medicines. Diovan will keep well if it is cool
and dry.
Keep the medicines where children cannot reach them.
A locked cupboard at least one-and-a-half metres above the ground is a good place
to store medicines.
Disposal
If your doctor tells you to stop taking Diovan, or the tablets have passed their expiry
date, ask your pharmacist what to do with any that are left over.
Product description
What it looks like
Diovan tablets are supplied in blister packs of 28.
Diovan 40 mg tablets are oval and yellow marked with “DO” on one side and “NVR” on
the other.
Diovan 80 mg tablets are round and pale red with a “D” and “V” marked on one side
of the tablet and “NVR on the other.
Diovan 160 mg tablets are oval shaped, and grey-orange in colour. They have the letters
“DX/DX” marked on one side of the tablet and “NVR” on the other.
Diovan 320 mg tablets are oval shaped, and grey-violet in colour. They have the letters
“DXL” marked on one side of the tablet and “NVR” on the other.
Ingredients
Diovan tablets contain 40 mg, 80 mg, 160 mg or 320 mg of valsartan as the active ingredient.
The tablets contain the following non active ingredients:
cellulose microcrystalline
crospovidone
silica – colloidal anhydrous
magnesium stearate
hypromellose
titanium dioxide
macrogol 8000
iron oxide red CI77491
iron oxide yellow CI77492
The 40 mg, 160 mg and 320 mg tablets also contain:
iron oxide black CI77499
Diovan tablets and capsules do not contain glucose, lactose, sucrose, saccharin, gluten,
tartrazine or other azo dyes.
Sponsor
Diovan is supplied in Australia by:
NOVARTIS Pharmaceuticals
Australia Pty Limited
ABN 18 004 244 160
54 Waterloo Road
North Ryde NSW 2113
Telephone: 1 800 671 203
®= Registered Trademark
This leaflet was prepared in February 2015.
Australian Registration Numbers:
Diovan 40 mg tabs AUST R 93165
Diovan 80 mg tabs AUST R 80868
Diovan 160 mg tabs AUST R 80871
Diovan 320 mg tabs AUST R 123357
For internal use only:
(CMI dvn140220c is based on PI dvn140220i)
💊 Composition of Diovan ® ✅ Application of Diovan ® Keep it for yourself Look for alternatives Interaction Description of the active ingredients of the preparation Diovan ® The scientific information provided is general and cannot be used to make decisions. Update date: 2020.03.25 Marketing authorization holder: NOVARTIS PHARMA, AG Manufactured:NOVARTIS PHARMA STEIN, AG (Switzerland) ATX code: C09CA03 (Valsartan) Active substance: Rec.INN WHO registered Dosage form
Release form, packaging and composition |
, coated shell, 80 mg: 14, 28, 56 or 98 pcs.
– blisters (4) – packs of cardboard. 
Does not interact with or block other hormone receptors or ion channels that are important for the regulation of the functions of the cardiovascular system. Does not affect the level of total cholesterol, TG, glucose and uric acid in plasma.
| I10 | Essential [primary] hypertension |
I50. 0 | Congestive heart failure |
Dosing regimen
The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.
Take orally at a dose of 80 mg 1 time / day or 40 mg 2 times / day, daily. In the absence of an adequate effect, the daily dose may be gradually increased.
The maximum daily dose of is 320 mg in 2 divided doses.
Side effects
From the side of the cardiovascular system: arterial hypotension, postural dizziness, postural hypotension.
From the side of the central nervous system: dizziness, headache.
From the digestive system: diarrhea, nausea, increased bilirubin levels.
From the urinary system: rarely – impaired renal function, increased levels of creatinine and urea nitrogen (especially in chronic heart failure).
From the side of metabolism: hyperkalemia.
From the side of the hematopoietic system: neutropenia, decrease in hemoglobin and hematocrit.
Allergic reactions: rarely – angioedema, rash, itching, serum sickness, vasculitis.
Other: fatigue, general weakness, cough, pharyngitis, increased risk of viral infections.
Contraindications for use
Pregnancy, hypersensitivity to valsartan.
Use in pregnancy and lactation
Valsartan is contraindicated in pregnancy.
It is not known whether valsartan is excreted in human breast milk. Use during lactation (breastfeeding) is not recommended.
In experimental studies valsartan has been shown to be excreted in breast milk in rats.
Use in impaired renal function
In patients with renovascular hypertension secondary to renal artery stenosis, serum urea and creatinine levels should be monitored regularly during treatment.
Data on the safety of use in patients with CC less than 10 ml / min are not available.
Due to inhibition of the RAAS in predisposed patients, changes in renal function are possible.
Use in children
The safety and efficacy of valsartan in children has not been established.
Special instructions
With hyponatremia and / or a decrease in BCC, as well as during therapy with high doses of diuretics, in rare cases, valsartan can cause severe arterial hypotension. Before starting treatment, correction of water-salt metabolism disorders should be carried out.
In patients with renovascular hypertension secondary to renal artery stenosis, serum urea and creatinine levels should be regularly monitored during treatment. Data on the safety of use in patients with CC less than 10 ml / min are not available.
Use with extreme caution in patients with biliary obstruction.
Due to inhibition of the RAAS in predisposed patients, changes in renal function are possible.
When using ACE inhibitors and angiotensin receptor antagonists in patients with severe chronic heart failure, oliguria and / or an increase in azotemia were observed, and acute renal failure with a risk of death rarely developed.
The safety and efficacy of valsartan in children has not been established.
Influence on the ability to drive vehicles and mechanisms
When using valsartan, it is recommended to be careful when driving a car and operating mechanisms.
Drug interactions
With the simultaneous use of diuretics in high doses, arterial hypotension may develop.
With the simultaneous use of potassium-sparing diuretics, heparin, dietary supplements or salt substitutes containing potassium, hyperkalemia may develop.
Co-administration with indomethacin may reduce the antihypertensive effect of valsartan.
When used simultaneously with lithium carbonate, a case of lithium intoxication has been described.
Keep
If you want to place a link to the description of this drug – use this code
Diovan ® .
Description of the drug in the reference book Vidal.
Ministry of Antimonopoly Regulation and Trade of the Republic of Belarus
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