How do antihistamines affect body weight. What are the mechanisms behind antihistamine-induced weight gain. Which antihistamines are most likely to cause weight gain. What are the alternative treatments for allergies that don’t contribute to weight gain. How can you manage allergies without compromising your weight loss goals.

The Link Between Antihistamines and Weight Gain

Allergy season can be a challenging time for many, with symptoms like runny nose, sneezing, and watery eyes affecting daily life. While over-the-counter antihistamines provide relief, they may come with an unexpected side effect: weight gain. Research has shown a correlation between antihistamine use and increased body weight, raising concerns for those managing both allergies and weight issues.

A 2010 study published in the journal Obesity by scientists from Yale University revealed that individuals taking antihistamines experienced weight gain. This finding has significant implications for allergy sufferers, especially considering that people with obesity are more prone to allergies.

How Do Antihistamines Affect Body Weight?

The mechanism behind antihistamine-induced weight gain involves several factors:

• Histamine receptors in the hypothalamus (the brain’s appetite control center) are blocked by antihistamines
• This blocking prevents the brain from receiving “fullness” signals
• Calorie burning becomes less effective when histamine receptors are blocked
• These changes lead to increased appetite, overeating, slower fat breakdown, and ultimately weight gain
• Antihistamines can cause fatigue, reducing motivation to exercise

Common Antihistamines Associated with Weight Gain

Not all antihistamines have the same effect on weight. Some are more likely to contribute to weight gain than others. The following antihistamines have been identified as potential culprits:

1. Diphenhydramine (Benadryl and others)
2. Cetirizine (Zyrtec)
3. Levocetirizine (Xyzal)
4. Fexofenadine (Allegra)
5. Hydroxyzine (Atarax, Vistaril)
6. Chlorpheniramine maleate (Chlor-Trimeton)

Is There a Weight-Friendly Antihistamine?

For those concerned about weight gain but still in need of allergy relief, loratadine (Claritin) may be the best option. Unlike other antihistamines, loratadine does not cross the blood-brain barrier. This means it cannot stimulate the brain’s appetite center or cause fatigue, making it less likely to contribute to weight gain.

Side Effects of Antihistamines Beyond Weight Gain

While weight gain is a significant concern, antihistamines can cause other side effects that users should be aware of:

• Dry mouth
• Drowsiness
• Dizziness
• Nausea and vomiting
• Restlessness or moodiness
• Trouble urinating
• Blurred vision
• Confusion

Understanding these potential side effects can help individuals make informed decisions about their allergy treatment options.

Alternative Treatments for Allergies

For those looking to manage their allergies without risking weight gain, several alternative treatments are available:

• Steroid nasal sprays
• Eye drops
• Decongestants
• Cromolyn sodium nasal spray
• Allergy shots (immunotherapy)

These alternatives can provide effective relief for many allergy sufferers without the potential for weight gain associated with certain antihistamines.

Non-Medicinal Approaches to Allergy Management

In addition to alternative medications, several non-drug strategies can help manage allergy symptoms:

• Frequent showers to remove allergens from the skin and hair
• Salt-water nasal washes to clear nasal passages
• Reducing exposure to allergy triggers (pollen, dust, mold, pet dander)
• Using air purifiers in the home
• Keeping windows closed during high pollen count days

Implementing these strategies can significantly reduce allergy symptoms without relying solely on medication.

The Obesity-Allergy Connection

Research has shown that individuals with obesity are more susceptible to allergies. This connection raises questions about the relationship between body weight and immune system function. While the exact mechanisms are not fully understood, several theories have been proposed:

• Increased inflammation in obese individuals may exacerbate allergic responses
• Hormonal changes associated with obesity could affect immune system regulation
• The presence of excess adipose tissue may alter the body’s response to allergens

This connection underscores the importance of managing both weight and allergies for overall health.

Balancing Allergy Relief and Weight Management

For individuals concerned about both allergy symptoms and weight gain, finding a balance between effective treatment and maintaining a healthy weight is crucial. Here are some strategies to consider:

• Consult with an allergist to develop a personalized treatment plan
• Explore non-sedating antihistamines or alternative treatments
• Incorporate regular exercise and a balanced diet to counteract potential weight gain
• Monitor weight regularly and adjust treatment if necessary
• Consider allergy shots for long-term management without daily medication

By taking a proactive approach, it’s possible to manage allergies effectively while minimizing the risk of weight gain.

The Role of Histamine in Metabolism

Histamine plays a complex role in the body beyond its involvement in allergic responses. Recent research has shed light on its importance in metabolism and weight regulation:

• Histamine is involved in regulating appetite and satiety
• It influences energy expenditure and fat metabolism
• Histamine receptors in the brain play a role in controlling food intake

Understanding this dual role of histamine in both allergic responses and metabolism helps explain why antihistamines can affect body weight.

The Future of Allergy Treatment

As research continues to uncover the complex relationships between allergies, weight, and overall health, new treatment approaches are being developed. Some promising areas of research include:

• Targeted therapies that address specific allergy pathways without affecting metabolism
• Personalized medicine approaches that consider individual genetic and metabolic profiles
• Combination therapies that provide allergy relief while supporting healthy weight management

These advancements hold the potential to provide more effective and tailored treatments for allergy sufferers in the future.

Seeking Professional Guidance

Managing allergies and weight concerns can be complex, and individual responses to treatments may vary. It’s essential to work with healthcare professionals to develop an appropriate management plan. Consider the following steps:

• Consult with an allergist to determine the best treatment approach for your specific allergies
• If weight is a concern, seek guidance from an obesity medicine specialist
• Regularly review and adjust your treatment plan as needed
• Consider a multidisciplinary approach that addresses both allergy symptoms and weight management

By working closely with healthcare providers, individuals can find effective solutions that address both their allergy symptoms and weight concerns.

The Importance of Holistic Health Management

When dealing with allergies and potential weight gain from treatments, it’s crucial to consider overall health and well-being. A holistic approach to health management can include:

• Stress reduction techniques, as stress can exacerbate both allergies and weight issues
• Adequate sleep, which is essential for immune function and weight regulation
• A balanced, nutrient-rich diet that supports immune health and weight management
• Regular physical activity, which can improve overall health and potentially reduce allergy symptoms

By addressing these various aspects of health, individuals may find they are better equipped to manage their allergies while maintaining a healthy weight.

Navigating Allergy Season: Practical Tips

As allergy seasons become more intense due to climate change, it’s important to have practical strategies for managing symptoms. Here are some additional tips to help navigate allergy season:

• Start allergy treatments before the season begins to prevent symptom onset
• Use pollen forecasts to plan outdoor activities
• Wear sunglasses and a hat when outdoors to reduce exposure to allergens
• Change clothes and shower after spending time outdoors
• Keep windows closed and use air conditioning with high-efficiency filters
• Vacuum regularly with a HEPA filter vacuum cleaner

Implementing these strategies can help reduce reliance on antihistamines and minimize potential side effects, including weight gain.

The Role of Diet in Allergy Management

While not a substitute for medical treatment, diet can play a supportive role in managing allergies. Some dietary considerations include:

• Consuming foods rich in quercetin, a natural antihistamine (e.g., onions, apples, berries)
• Increasing intake of omega-3 fatty acids, which may help reduce inflammation
• Staying hydrated to help thin mucus and ease congestion
• Considering probiotics to support gut health and immune function

A balanced diet that supports overall health can complement other allergy management strategies and potentially reduce the need for medications that may contribute to weight gain.

Emerging Research and Future Directions

The field of allergy research is continually evolving, with new insights emerging about the relationship between allergies, weight, and overall health. Some areas of ongoing research include:

• The role of the gut microbiome in allergic responses and weight regulation
• Genetic factors that influence both allergy susceptibility and metabolism
• Novel immunotherapy approaches that may provide long-term allergy relief without side effects
• The potential use of histamine receptor modulators that target specific receptors without affecting appetite or metabolism

As this research progresses, it may lead to new treatment options that effectively manage allergies without impacting weight or other aspects of health.

The Importance of Patient Education

Empowering patients with knowledge about their allergies, treatment options, and potential side effects is crucial for effective management. Healthcare providers play a key role in this education process by:

• Discussing the pros and cons of different treatment options
• Explaining the potential for weight gain with certain antihistamines
• Providing guidance on lifestyle modifications to support allergy management
• Encouraging patients to report any side effects or concerns promptly

Informed patients are better equipped to make decisions about their allergy treatment and to proactively manage potential side effects like weight gain.

Conclusion: A Balanced Approach to Allergy Management

Managing allergies effectively while maintaining a healthy weight requires a balanced, individualized approach. By understanding the potential effects of antihistamines on weight, exploring alternative treatments, and implementing lifestyle strategies, it’s possible to find relief from allergy symptoms without compromising weight management goals. As research continues to advance our understanding of allergies and their treatments, new options may emerge that provide even better solutions for those struggling with both allergies and weight concerns.

Remember, the key to successful allergy management lies in working closely with healthcare providers, staying informed about treatment options, and taking a holistic approach to health. By considering all aspects of well-being, including allergy symptoms, weight, diet, and lifestyle, individuals can develop a comprehensive strategy for managing their allergies effectively and maintaining overall health.

Scott D. Isaacs, MD: Endocrinologist

Allergy season is here. We are experiencing record pollen counts this year and you may be experiencing symptoms like runny nose, sneezing, and watery eyes. Many people treat seasonal allergies with over-the-counter antihistamines, but did you know that these medications could be making you gain weight? 

Studies have shown that people with obesity are more prone to allergies, and this may have to do with the medications used to treat seasonal allergies. Scientists from Yale University published a study in 2010 in the journal Obesity showing that people who took antihistamines gained weight.

Histamine is known to affect body weight. The appetite control center of the brain known as the hypothalamus contains receptors for histamine. When histamine receptors are blocked by an antihistamine medication, the brain doesn’t receive the “I’m full” signal like it normally would. The body also can’t burn calories effectively when the histamine receptor is blocked, lowering metabolism. These biological changes result in increased appetite, overeating, slower fat breakdown and weight gain. Antihistamines can also make you feel tired and unmotivated to exercise.

Antihistamines that can cause weight gain include:

• Diphenhydramine (Benadryl and others)
• Cetirizine (Zyrtec)
• Levocetirizine (Xyzal)
• Fexofenadine (Allegra)
• Hydroxyzine (Atarax, Vistaril)
• Chlorpheniramine maleate (Chlor-Trimeton)

If you need to take an antihistamine your best bet is loratadine (Claritin). This is because loratadine does not cross into the brain and therefore cannot stimulate the appetite center of the brain and does not cause fatigue.

Other side effects of antihistamines include:

• Dry mouth
• Drowsiness
• Dizziness
• Nausea and vomiting
• Restlessness or moodiness
• Trouble urinating
• Blurred vision
• Confusion

Alternative allergy treatments include steroid nasal spray and eye drops, decongestants, cromolyn sodium nasal spray and allergy shots. Frequent showers and salt-water nasal washes can also be helpful. Non-drug strategies to dealing with allergies include reducing exposure to allergy triggers like pollen, dust, mold or pet dander.  

If you’re struggling with weight loss, you need the help of an obesity medicine specialist. If you’d like to learn more about permanent weight loss, please feel free to call us or schedule an appointment with Dr. Isaacs using the online booking tool on this website.

Author

Scott Isaacs, MD
Endocrinologist and Weight Loss Specialist

Treatment of Hepatic Hypothyroidism

Hepatic hypothyroidism is not a thyroid disorder and is not treated with thyroid medications, thyroid supplements, or a thyroid diet.

March is National Nutrition Month

Today about half of all American adults have one or more chronic diseases, often related to poor diet.

February is National Heart Health Month

Heart disease doesn’t happen just to older adults. It is happening to younger adults more and more often. This is partly because the conditions that lead to heart disease are happening at younger ages.

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January is Healthy Resolutions Month

Some people’s challenges are more daunting than others, and it can be disappointing when we abandon our resolutions after only a few weeks. No matter what you have resolved to do this year, it is always best to approach it with a plan.

Antihistamines and Weight Gain | Obesity Medicine Association

Benadryl, Allegra, Zyrtec, Claritin are all antihistamines sold throughout the United States, both over the counter and via prescription. Anyone who suffers from chronic sinus congestion, runny noses, hives, or even occasional insomnia is aware that these medications are powerful tools in our pharmaceutical arsenal. Given histamine receptors are located throughout our body, these drugs can affect us in many ways, including weight gain.

What is Histamine?

Histamine is a molecule famously known to be a key player in allergic responses. It is released by cells called mast cells at the membranes that cover our noses, mouths, lungs, and stomachs when exposed to an allergen (something that results in allergies such as pollen, dust, etc). This results in our small blood vessels known as capillaries becoming more permeable allowing white blood cells to move into the vessels to attack the foreign body. The intention of this process is to help expel potential intruders, but often our immune system overreacts and leads to burdensome runny noses, congested sinuses, and rashes.

Histamine also acts as a neurotransmitter in our brains playing a key role in wakefulness and preventing sleep, which is why Benadryl (an anti-histamine) makes you sleepy. This effect may actually be one of the reasons why anti-histamines are among the medications that can cause weight gain.

What is the relationship between antihistamines and weight gain?

The major study which somewhat demonstrates the relationship between antihistamines and weight gain come from the journal of Obesity[1] in 2010 which used the National health and Nutrition Examination Survey (NHANES) data set to study the issue. The NHANES is an annual health survey conducted by the National Center for Health Statistics (NCHS), where the NCHS staff drive trailers across the United States and conduct interviews, medical histories, physical examinations, and laboratory testing to determine the prevalence of and risk factors for major diseases. This data is then available to the public for research.

For this particular study researchers from the Yale University School of Medicine looked at the NHANES data set from 2005-2006, looking at 268 adults (174 female and 94 male) who reported the use of a prescription antihistamines such as Zyrtec and Allegra, and compared them to 599 people (401 female and 198 male) who did not, looking at differences in body mass index (BMI), cholesterol and glucose levels. After doing a statistical adjustment for gender and age, the researchers found that those who used prescription anti-histamines displayed significantly greater BMI, waist circumference, and insulin levels, but no differences between cholesterol and fasting glucose levels, demonstrating a correlation between using anti-histamines and higher weight. Specifically, anti-histamine users had an average BMI of 30 versus a BMI of 28-29 for men and women who did not use the drugs. In pounds men who used anti-histamines had an average weight of 214 pounds versus 192 and women had an average of 176 pounds versus 166 pounds.

This seems to suggest that antihistamines could be a factor in weight gain. However, the important thing to note is that this is a cross-sectional study and just because in this case antihistamine use and weight gain are related, it doesn’t mean one necessarily causes the other. Also, the study looked at only prescription antihistamines such as Zyrtec and Allegra not over-the-counter medications like Benadryl (although now many over-the-counter anti-histamines have the same strength as the prescription versions).

Still, from clinical experience and solid scientific research demonstrating how histamine affects our appetites, it is safe to say that anti-histamines probably do affect weight gain. Moreover, antipsychotics like Zyprexa have a significant anti-histamine effect and are well known to result in dramatic weight gain.

Why do anti-histamines cause weight gain?

Histamine decreases our hunger by in part affecting the appetite control center in our brains[2], and it makes sense an anti-histamine would have the opposite effect. These drugs can interfere with the “I’m full” signal coming from the rest of our bodies and lead to overeating. Medications like Allegra and Benadryl also have the effect of making us sleepier, decreasing the amount of energy we use, and leading to fewer calories burned throughout the day. While first-generation antihistamines like Benadryl are more prone to make you sleepy, even second-generation medications like Zyrtec, when broken down by the body, resulting in byproducts that have a mild sedative effect.

Do antihistamines cause weight gain?

The short answer seems to be yes. While occasionally taking a Benadryl for sleep probably won’t lead to significant weight gain, chronic use of antihistamines can interfere with weight loss efforts. If you need an antihistamine for frequent allergy symptoms, however, the best choice is Claritin because it does not cross into the brain and has less effect on appetite and sedation. Otherwise, steroid nasal sprays, decongestants, and just reducing exposures to allergens are other options.

Written by: Vivek Gupta, MD, MPH

Which drugs make you gain weight

If you are prescribed a drug and start to gain weight, the two events are not necessarily related. Some groups of drugs can really affect weight gain, but not in the way you think.

Tags:

weight loss

Excess weight

The fight against excess weight

Medications

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Perhaps you are taking some kind of medication and have started noticing how the numbers on the scale are getting bigger. Look in the instructions for the group of your drug and perhaps it will be on this list.

Contents of the article

Do not self-medicate! In our articles, we collect the latest scientific data and the opinions of authoritative health experts. But remember: only a doctor can diagnose and prescribe treatment.

1. Why does the drug cause weight gain?

By itself, the drug does not form fatty tissue from nothing. Reasons your drug may cause weight gain include side effects such as:

• increased appetite

• water retention

• intense accumulation of fat from incoming food (faster than usual)

• slow metabolism 900 31

• fatigue, lethargy or weakness

2. Medicinal drugs

2.1 Antidepressants

Some antidepressants can cause weight gain by affecting the neurotransmitter serotonin, which affects our mood. You become more relaxed, your well-being improves, and with it your appetite. Other antidepressant options can cause drowsiness and fatigue, which reduces your level of activity, and therefore the expenditure of energy, which is then stored as adipose tissue.

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2.2 Contraceptives

This class of drugs is most often blamed for weight gain. In general, birth control pills are not associated with weight gain, especially the newer pills with lower doses of estrogen and progestin. A significant effect can be observed only with injections. And so again we return to the revision of the calorie content of the diet and the level of physical activity.

2.3 Antihistamines

Blocking histamine activity may increase appetite. Used to treat allergic conditions.

2.4 Antipsychotics and the treatment of mood disorders

Although all antipsychotics have been shown to cause some metabolic and weight changes, each drug has its own risk profile. They have a similar effect to antidepressants. This class of drugs is used for mental illness.

2.5 Beta blockers

Beta blockers are a class of heart drugs used to treat high blood pressure and chest pain (angina). They can cause fatigue. A person lacks energy and slows down, which can affect the number of calories burned per day

2.6. Corticosteroids

Steroids can affect the metabolic rate and lead to increased appetite and overeating. This class of drugs can lead to additional deposits of fat in the middle part of the body (in the abdomen). They are often used for a short time

2.7 Diabetes medicines

May cause weight gain, both through increased appetite and increased glucose uptake into cells. Too many calories in the form of glucose will lead to weight gain (as insulin injections can). But remember that nutrition and physical activity can control such effects.

2.8 Anticonvulsants, mood stabilizers and migraine medicines

Have a similar body weight gain mechanism to previous classes. Long-term use of this group of drugs can cause significant weight gain

3. What should I do?

Other drugs will not have any significant effect on your weight. Get back to the basics:

1. a balanced diet

2. regular physical activity

3. quality sleep and rest

If you are all – you are still taking one of the above drugs, consult your doctor, but do not stop the drug yourself .

(Also: How taking antidepressants affects weight: here’s what scientists say)

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Creation date: 04/27/2021
Update date: 07/04/2023

Warehouse and release form

1 tablet, coated with a shell, Xyzal Mist:

• Levocetirizine dihydrochloride – 5 mg drops for oral congestion Xyzal mist:
  • Levocetirizine dihydrochloride – 5 mg
  • additional ingredients

  In 1 ml of Xizal preparation – 20 droplets.

  Tablets, coated with shell, Xyzal 7 or 10 pieces packaged in blister packs, 1 or 2 pods in a cardboard box.

  Oral drops Xyzal 10 ml in dark-coloured bottles with a small dropper, in a carton pack of 1 bottle.

  Pharmacological action:

  Xizal is a medicinal preparation that exhibits antihistamine and antiallergic action. The active ingredient in Xizal is levocetirizine, the R-enantiomer of cetirizine. Levocetirizine competitively blocks H1-histamine receptors, and the pharmacological activity of levocetirizine is almost 2 times greater than that of cetirizine.
  Xyzal is added to the histamine-dependent phase of the allergic reaction. In addition, levocetirizine leads to a change in the migration of eosinophils and a decrease in the penetration of the vessel wall. Ksizal also improves the viability of cytokines and mediators of inflammation.

  The drug may have anti-verb and anti-exudative effects, ease the overshoot and prevent the development of allergic reactions. Levocetirizine practically does not affect cholinergic and serotonin receptors, does not have a significant sedative effect.
  After oral administration, levocetirizine is well absorbed in the intestinal tract. Taking the drug at the same time as taking the drug should not lead to a change in the bioavailability and speed of absorption of levocetirizine.

  Peak plasma concentration of active speech is reached within 1 year after intake. Equal plasma concentrations are available for other dobu therapy Levocetirizine.

  The degree of binding of levocetirizine with plasma proteins reaches 90%, oral bioavailability 100%. An insignificant world is metabolized in organisms. It is excreted most importantly by channels of tubular secretion and glomerular filtration.

  Approximately 13% of levocetirizine is excreted by the intestine. The period of drinking varies from 6 to 10 years, depending on the individual characteristics of the patient. In children, the period of administration of levocetirizine shortened.
  Patients with impaired function of nirok show an increase in the period of drinking. It is practical not to administer levocetirizine during hemodialysis (during 4-year hemodialysis, no more than 10% levocetirizine should be administered).
  The active ingredient of Xyzal passes into breast milk.

  Indications before congestion:

  Existing indications for symptomatic therapy of patients who suffer from the color and seasonal form of allergic conjunctivitis and rhinitis, I are accompanied by wheezing, swelling of the nasal mucosa, lacrimation, rhinorrhea and hyperemia of the nasal mucosa and con’ junctiv.
  Xizal is also prescribed to patients who suffer from polynosis, a chronic form of idiopathic croup, flare-ups and allergic dermatoses, as they are accompanied by visip and severbitis.

  Method of administration:

  Tablets, coated with shell, Xizal:

  Prescription drug for oral administration. It is not recommended to take a pill or to open the pill. Ksizal should be taken directly in the form of a drink, a tablet should be washed down with a small amount of drinking water.

  Trivality of the course of treatment and doses of levocetirizine indicates a favorable drug.
  Adults and children over 6 years of age are usually given 1 tablet Xyzal per day.
  For children younger than 6 years of age, it is recommended to administer the drug in the form of oral droplets.

  Patients with reduced function nirok should adjust the dose of levocetirizine:
  With creatinine clearance of 30 to 50 ml / min, as a rule, prescribe 1 tablet of the drug Xizal 1 time in 48 years.
  When creatinine clearance is 10 to 30 ml/min, as a rule, 1 tablet of Xizal is prescribed once every 72 years.
  When creatinine clearance becomes less than 10 ml/min (patients on hemodialysis), levocetirizine does not stop.
  With normal function of the liver in patients with a frail age and patients with impaired liver function, the dose of levocetirizine should not be corrected.
  Trivality of rejoicing to become from 1st day to 6 months in fallow land due to the nature of the disease. In the last few days, the course is continued for up to 12 months under the control of the doctor.

  Oral drops Xyzal:

  The drug is taken directly in the middle of the intake. If necessary, I will need to dilute a small amount of drops in a small amount of drinking water (no more than 10 ml). The validity of the intake and dose of Xizal depends on the drug.
  Adults and children older than 6 years old, as a rule, are prescribed 20 drops of the drug Xizal per dose. The additional dose is recommended to be taken in 1 dose.
  Children aged 2 to 6 years, as a rule, are prescribed 5 drops of the drug Ksizal dvіchi per doba.
  The maximum recommended additional dose of levocetirizine for adults and children older than 6 years is 5 mg.
  The maximum recommended additional dose of levocetirizine for children aged 2 to 6 years is 2.5 mg.

  Patients with impaired creatinine clearance, doses of levocetirizine should be carried out to improve indications of creatinine clearance:
  Patients with creatinine clearance, 30 to 50 ml / min As a rule, prescribe 20 drops of Xizal once every 48 years.
  Patients with a creatinine clearance of 10 to 30 ml/min are usually given 20 drops of Xizal once every 72 years.
  Do not prescribe levocetirizine to patients who are on hemodialysis.
  Patients with a frail age and patients with impaired liver function with normal function need no dose adjustment of levocetirizine.
  The duration of therapy, as a rule, becomes from 1 day to 6 months. In other cases, under the close supervision of the doctor, the course of healing can be increased up to 18 months.

  Side effects:

  Ksizal, as a rule, is badly tolerated by patients. During the period of Levocetirizine therapy in some patients, the development of the following unimportant effects was noted:
  On the side of the organs of the sensitivity and the central nervous system: decreased vision, drowsiness, increased stupor, headache, aggression, asthenia, depressive states. In lonely moods, the development of hallucinations and judgment is possible.

  On the side of the intestinal tract and liver: discomfort and pain in the epigastric cavity, dryness of the mucous membrane of the mouth, nausea, diarrhea, hepatitis, increased liver enzymes. In lonely cases, a change in the mass of the body was indicated.
  Allergic reactions: kropivyanka, sverbizh shkir and visip, anaphylactic shock, angioedema.
  Інші: hastened heartbeat, butt, butt, bіl in m’yazah.

  Contraindications:

  Xizal should not be prescribed to patients with individual hypersensitivity to levocetirizine and similar piperazine.
  Coated tablets, Xyzal are not recommended for patients with glucose-galactose malabsorption syndrome, galactosemia and lactase deficiency.
  Levocetirizine has not been indicated in patients with severe thyroid dysfunction (creatinine clearance less than 10 ml/min).
  Xyzal is not recommended for use during pregnancy and lactation.
  Tablets, coated with a shell, not vicarious for the delight of children under 6 years of age.
  Oral drops are not vicorous for the delight of children up to 2 years of age.

  It is recommended to take precautions by prescribing levocetirizine to patients with impaired function, chronic alcoholism, and patients of a frail age.
  Patients who drive a car or operate potentially unsafe mechanisms should be especially careful during the hour of Levocetirizine therapy.

  Vagination:

  Levocetirizine should not be used for therapy in women during pregnancy, in connection with the daily reliable data on the infusion of levocetirizine during the period of pregnancy vagity.
  In the period of lactation, the drug Xizal may be used only after the development of nutrition about the risk of breastfeeding, while levocetirizine passes into breast milk.

  Interaction with other medical problems:

  May be able to increase the period of administration of levocetirizine in case of one-hour ingestion with theophylline.
  It is not recommended to administer levocetirizine with ethyl alcohol and drugs overnight, as they depress the central nervous system.

  Overdose:

  Taking high doses of levocetirizine may cause unreasonable restlessness, arousal or drowsiness. Moreover, it is possible to strengthen the manifestation of negligible effects.
  There is no specific antidote. When taking high doses of the drug, it is necessary to skip the tube and sign the intake of enterosorbents. If necessary, carry out therapy directed at the symptoms of intoxication.
  Carrying out hemodialysis with overdose of levocetirizine is not effective.

  Wash up the savings:

  Drops oral Xyzal next save no more than 2 years after preparation.

  Tablets, coated with shell, Xyzal should save no more than 3 years after preparation.

  Directly dispensed, the drug is taken in places where the temperature does not exceed 25 degrees Celsius.

  Oral droplets should be taken no more than 3 months after the first vial opening.