Female hormone patch: Estradiol Transdermal Patch: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

05.07.202315.06.2023 by alexxlab

Estradiol Transdermal Patch: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Estrogens, either used alone or with another hormone (progestin), have rarely caused very serious side effects. Discuss the risks and benefits of hormone treatment with your doctor. Estrogens should not be used to prevent heart disease or dementia.

Estrogens can increase the risk of cancer of the uterus (endometrial cancer). Taking a progestin as directed by your doctor can help decrease this risk. Tell your doctor right away if you have any unusual vaginal bleeding.

In postmenopausal women, estrogens, taken with or without a progestin, increase the risk of cancer of the breast/ovaries, stroke, dementia, and serious blood clots. When used along with a progestin, estrogens also increase the risk of heart disease (such as heart attacks).

The risk for serious side effects may depend on the dose of estrogen and the length of time it is used. This medication should be used at the lowest effective dose and for the shortest amount of time. Discuss the use of this medication with your doctor and check with him/her regularly (for example, every 3 to 6 months) to see if you still need to use this medication. If you will be using this medication long-term, you should have regular complete physical exams (for example, once a year) as directed by your doctor. See also Notes section.

Warnings:

Uses

This medication is a female hormone (estrogen). It is used by women to help reduce symptoms of menopause (such as hot flashes, vaginal dryness). These symptoms are caused by the body making less estrogen. If you are using this medication to treat symptoms only in and around the vagina, products applied directly inside the vagina should be considered before medications that are taken by mouth, absorbed through the skin, or injected. This medication may also be used by women who are not able to produce enough estrogen (for example, due to hypogonadism, primary ovarian failure).Certain estrogen products may also be used by women after menopause to prevent bone loss (osteoporosis). However, there are other medications (such as raloxifene, bisphosphonates including alendronate) that are also effective in preventing bone loss and may be safer. These medications should be considered for use before estrogen treatment.

How to use Estradiol Transdermal Patch 0.1 Mg/24 Hr

Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Peel off the backing from the patch and apply the patch to a clean, dry area of the lower stomach or the top of the buttocks. Press the patch firmly in place for about 10 seconds to make sure it stays on. Do not apply the patch on the breast or on oily, broken, or irritated skin. Avoid applying the patch to areas of the skin where it might be easily rubbed off (such as the waistline). Use this medication as directed by your doctor. The patch is usually worn for 1 week and then replaced. Follow the dosing schedule carefully.

The dosage is based on your medical condition and response to treatment.

When replacing your patch, make sure to apply the new patch to a different area. Wait at least 1 week before applying a patch to the same area. Fold the old patch in half with the sticky side together and throw away in the trash away from children and pets. Do not flush the patch down the toilet.

If a patch falls off, reapply it to a different area. If the patch does not stick completely, then apply a new patch and wear it for the rest of the 7-day period. Do not wear 2 patches at the same time.

Use this medication regularly to get the most benefit from it. To help you remember, change the patch on the same day each week. It may help to mark your calendar as a reminder.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Precautions

Before using estradiol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (such as heart attack), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), gallbladder disease, asthma, seizures, migraine headaches, a certain blood disorder (porphyria), mental/mood disorders (such as dementia, depression).

Do not smoke or use tobacco. Estrogens combined with smoking further increases your risk of stroke, blood clots, high blood pressure, and heart attack, especially in women older than 35.

Tell your doctor if you just had or will be having surgery, or if you will be confined to a chair or bed for a long time (such as a long plane flight). These conditions increase your risk of getting blood clots, especially if you are taking an estrogen product. You may need to stop this medication for a time or take special precautions.

This medication may cause blotchy, dark areas on your face and skin (melasma). Sunlight may worsen this effect. Limit your time in the sun. Avoid tanning booths and sunlamps. Use sunscreen and wear protective clothing when outdoors.

If you are nearsighted or wear contact lenses, you may develop vision problems or trouble wearing your contact lenses. Contact your eye doctor if these problems occur.

If you are going to have an MRI test, tell testing personnel that you are using this patch. Some patches may contain metals that can cause serious burns during an MRI. Ask your doctor whether you will need to remove your patch before the test and apply a new patch afterward, and how to do so properly.

Children may be more sensitive to the side effects of this drug. It may affect their growth/development. Discuss the possible effects of this medication with the doctor, and monitor your child’s growth periodically.

This medication should not be used during pregnancy. If you become pregnant or think you may be pregnant, tell your doctor right away.

This medication passes into breast milk. It may reduce the quality and amount of breast milk produced. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug include: aromatase inhibitors (such as anastrozole, exemestane, letrozole), fulvestrant, ospemifene, raloxifene, tamoxifen, toremifene, tranexamic acid.

This medication may interfere with certain laboratory tests (including metyrapone test), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.

Does Estradiol Transdermal Patch 0.1 Mg/24 Hr interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

This medication patch may be harmful if chewed or swallowed. If someone has overdosed, remove the patch if possible. For serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

Regular complete physical exams which include lab and/or medical tests (such as blood pressure, breast exam/mammogram, pelvic exam, Pap smear) should be done while you are using this medication. Follow your doctor’s instructions for examining your breasts, and report any lumps right away. Keep all medical and lab appointments. Consult your doctor for more details.

Preventing or controlling high blood pressure, high cholesterol, and diabetes can help to reduce your chances of heart disease and stroke. Lifestyle changes that can help to control or prevent these diseases include reducing stress, eating a low fat/salt diet, losing weight if overweight, exercising regularly, and stopping smoking. Keep your mind active with mental exercises (such as reading, solving crossword puzzles) to help prevent dementia. Talk to your doctor about lifestyle changes that might benefit you.

Lifestyle changes that may help reduce hot flashes include stopping smoking, dressing lightly or in layers, avoiding/limiting certain foods (spicy foods, caffeine, alcohol), reducing stress, and exercising regularly.

Lifestyle changes that help promote healthy bones include increasing weight-bearing exercise, stopping smoking, limiting alcohol, and eating well-balanced meals that contain adequate calcium and vitamin D. Since you may also need to take calcium and vitamin D supplements and make lifestyle changes, consult your doctor for specific advice.

If you forget to replace a patch at the scheduled time, replace it as soon as you remember. Do not use more than one patch at a time.

Store at room temperature. Do not remove the patch from the pouch until ready for use. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed (See How to Use section).

Images

Available coupons

Save up to 80% on your prescription with WebMDRx

Drug Survey

Are you currently using Estradiol Transdermal Patch 0.1 Mg/24 Hr?

This survey is being conducted by the WebMD marketing sciences department.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

The Benefits of the Estrogen Patch For Menopause

Overview

As women approach menopause, fluctuations and drop in ovarian hormones—particularly estrogen—can cause an array of uncomfortable and life disrupting symptoms, including hot flashes, night sweats, vaginal dryness, and pain during sex.

The good news? Evidence shows that hormone therapy (HT) is the most effective therapy to manage the vasomotor symptoms of perimenopause and menopause. HT can also help mitigate other menopausal symptoms, including mood and sleep changes, brain fog, and low libido.

What is estrogen therapy?

Estrogen therapy, generally called hormone therapy (HT) when combined with a progestogen, is an effective treatment for menopausal and perimenopausal symptoms.

There are several types of estrogen made by the body that can be supplemented, including estrone (made primarily in the fat tissue), estradiol (the most potent estrogen present in the body before menopause made by the ovaries), and estriol (the weakest estrogen, primarily present during pregnancy).

Most women can safely begin taking estrogen therapy once they are in perimenopause or menopause and are displaying the symptoms of reduced or fluctuating estrogen. Your doctor can help you determine your eligibility based on your symptoms and some other key questions about your medical history. If your symptoms are bothering you, estrogen therapy is worth considering given its efficacy at diminishing menopause symptoms.

What is an estrogen patch and why would I need it?

An estrogen patch is a form of estrogen therapy used to manage symptoms associated with menopause. The hormone from the patch is absorbed through the skin and into the body to prevent and manage symptoms such as hot flashes and night sweats. If you’re looking for a way to manage and treat symptoms associated with menopause, the estrogen patch may be right for you.

Benefits of the estrogen patch

For many women, finding the right HT can be confusing, given that most menopause hormone therapies, including those at Evernow, are available in the form of a patch, pill, or cream. What’s more, some women may require estrogen-only therapy, while others will require a combination of estrogen and progesterone.

While it’s not the best choice for everyone, general benefits of the patch include:

More direct form of estrogen delivery. In a 2017 study, researchers found that women on the estrogen patch had a ratio of estradiol to estrone (the two types of estrogen hormone) that was nearly identical to the ratio before menopause. Additionally, estradiol from patches is absorbed from the skin directly into the bloodstream. What’s more, when given an equal dose, the concentration of free estradiol in the blood of women using the patch was twice that of those who used the pill.
It may significantly improve your libido. The same 2017 study also measured Female Sexual Function Inventory (FSFI) and found that women using the patch had a 7.2% improvement in their scores while the women using the oral estrogen experienced a smaller effect. Most notably, at 18 months women on the patch experienced significant improvement in vaginal lubrication, pain during sex, and overall libido and desire. When compared with oral estrogen, the primary benefits were an increase in arousal and desire.
It may also help protect against Alzheimers. One early research study suggests that estrogen patch may have a beneficial impact on cognitive biomarkers in comparison with the pill form of estrogen or placebos. Though more research is required to determine this relationship, data from the Kronos Early Estrogen Prevention Study (KEEPS) found that women who received the estrogen patch had the highest maintenance of brain volume in the dorsolateral prefrontal cortex—the part of the brain that helps with memory, thinking, planning, and reasoning. These women were also more likely to have a lower amount of the amyloid plaque deposits that are related to Alzheimer’s disease.

Is the menopause patch safe?

Yes, both the pill and the patch have been shown to be safe and effective treatments for the symptoms of menopause. But when comparing the two, one study that followed 54,000 women for one year found that those who used estrogen patches were one-third less likely to develop blood clots in their legs or lungs.

Though there are some unique benefits of the estrogen patch, the science is clear: hormone therapy is safe and effective at providing relief from menopause symptoms, regardless of the form of delivery.

Why wouldn’t I use the patch?

The patch’s effectiveness requires it to stick to your skin. This works well for many, but women who swim frequently, sweat profusely, or soak in hot tubs and baths might not be great candidates for the patch.

Are there any risks or side effects to keep in mind?

The estrogen patch isn’t right for everyone. Women with certain medical conditions or predispositions will need to be assessed closely by a medical provider to determine their eligibility for HT, and type of HT. These risk factors are highly personalized and vary depending on a woman’s age, and her individual medical history.

A personal history of the following conditions could put you at risk for vascular complications on HT:

Breast or uterine cancer
Certain heart or vascular conditions—such as blood clots, stroke, heart attack, coronary heart disease, or uncontrolled hypertension.
Liver disease
Gallbladder disease
Lupus
Unexplained vaginal bleeding

Screening for these risk factors is a standard part of the assessment for HT eligibility and treatment, including treatment with Evernow.

Sources

Effects of Oral vs Transdermal Estrogen Therapy on Sexual Function in Early Postmenopause. (2017). https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2652573
Estradiol. (2021). https://www.mayoclinic.org/drugs-supplements/estradiol-transdermal-route/description/drg-20075306
Estrogen. (2021). https://www.ncbi.nlm.nih.gov/books/NBK538260/
Hormone Replacement Therapy. (2020). https://www.va.gov/WHOLEHEALTHLIBRARY/docs/Hormone-Replacement-Therapy.pdf

Local estrogens for vaginal atrophy in postmenopausal women

Review question

The Cochrane researchers reviewed the evidence for the efficacy and safety of intravaginal estrogen preparations versus each other or placebo (inactive or sham treatment) in women treated for symptoms of vaginal atrophy.

Relevance

Vaginal atrophy is a common condition in postmenopausal women. This leads to vaginal dryness and itching, as well as pain during sexual intercourse. The female hormone estrogen is one of the treatments for vaginal atrophy, but can cause adverse effects such as thickening of the lining of the uterus (endometrium) due to endometrial hyperplasia or cancer (leading to vaginal bleeding) and breast pain . Estrogen preparations are available as oral tablets, skin patches, or subcutaneous implants. Alternatively, women can apply this hormone topically in the form of creams, pessaries (which are inserted into the vagina), or a special hormone-releasing ring that is inserted into the vagina. Therefore, the efficacy and safety of these topical estrogen preparations need to be evaluated.

Study profile

We found 30 randomized controlled trials comparing intravaginal estrogen preparations with each other or with placebo in 6235 postmenopausal women treated for symptoms of vaginal atrophy. The evidence is current to April 2016.

Main results

There was no evidence of a difference in the proportion of women reporting improvement in symptoms of vaginal atrophy when the following therapies were compared: estrogen ring vs estrogen cream, estrogen ring vs estrogen pill, estrogen tablet vs estrogen cream, estrogen cream vs estrogen gel isoflavones. However, a higher proportion of women reported improvement in symptoms when the following active therapies were compared with placebo: estrogen ring versus placebo, estrogen pills versus placebo, and estrogen cream versus placebo. When comparing estrogen pills versus placebo and using a random effects model to analyze the data, due to existing heterogeneity, there was no longer evidence of a difference in efficacy in reducing symptoms.

In terms of safety, a higher proportion of women treated with estrogen cream experienced an increase in endometrial thickness compared to those treated with estrogen ring, which could be due to the higher doses of cream used. However, there was no evidence of a difference in the proportion of women with increased uterine lining thickness when using estrogen tablets or estrogen cream.

Quality of evidence

The quality of the evidence was low, both for the improvement in symptoms reported by women and the increase in endometrial thickness. The main limitations of the evidence were the poor presentation of study methods and imprecision (i.e., estimates of effect with wide confidence intervals) in results for both outcomes.

Translation notes:

Translation: Chuprova Natalya Sergeevna. Editing: Ziganshin Airat Usmanovich. Project coordination for translation into Russian: Cochrane Russia – Cochrane Russia (branch of the Northern Cochrane Center on the basis of Kazan Federal University). For questions related to this translation, please contact us at: [email protected]; [email protected]

Register of Medicines of Russia RLS Patient 2003.

Other drugs of this pharmacological group are listed below. For more information, please visit www.rlsnet.ru.

[ Trade name (composition or characteristic) pharmacological action dosage forms company ]

Agnucaston (medicine of plant origin) hypoprolactinemic oral drops; tabl.p.o. Bionorica (Germany)

Aromasin (exemestane) antiestrogen, antitumor tabl.p.o. Pharmacia (USA)

Vero-tamoxifen (tamoxifen) antitumor, antiestrogen tab. Veropharm (Russia), manufacturer: Veropharm (Belgorod branch) (Russia) Schering (Germany)

Diane-35 (cyproterone + ethinyl estradiol) estrogenic, antiandrogenic, progestogen, contraceptive dragee Schering (Germany)

900 02 Duphaston (dydrogesterone) progestogen p. p.o. Solvay Pharmaceuticals (Germany), manufacturer: Solvay Pharmaceuticals (Netherlands)

Jeanine (dienogest + ethinyl estradiol) contraceptive dragee 9000 3 Schering (Germany)

Zitazonium (tamoxifen) antitumor, antiestrogen tab. Egis (Hungary)

Klimadinon (herbal product) estrogen-like, anticlimacteric oral solution; tabl.p.o. Bionorica (Germany)

Climaksan homeopathic (homeopathic remedy) vegetotropic, sedative gran. Materia Medica Holding (Russia), manufacturer: Materia Medica (Russia)

Klimara (estradiol) estrogenic patch-TDTS Schering (G Germany)

Klimen (cyproterone + estradiol) anticlimacteric, estrogenic, gestagenic, antiandrogenic Schering (Germany)

Climodien (dienogest + estradiol valerate) anticlimacteric, estrogenic, gestagen noe, antiandrogenic tabl. p.o. Schering (Germany)

Klimonorm (levonorgestrel + estradiol) anticlimacteric, estrogen-progestogen dragee Schering (G Germany)

Kliogest (norethisterone + estradiol) estrogen-gestagen tabl.p.o. . Novo Nordisk (Denmark)

Clostilbegit (clomiphene) antiestrogen tab. Egis (Hungary)

Logest (gestodene + ethinylestradiol) contraceptive dragee Schering (Germany)

Microgynon (levonorgestrel + ethinyl estradiol) estrogen-progestin, contraceptive dragee Schering (Germany)

Microlute ( levonorgestrel) contraceptive, progestogen dragee Schering (Germany)

Minisiston (levonorgestrel + ethinyl estradiol) estrogen-progestin, contraceptive dragee Schering (Germany)

Mirena (levonorgestrel) contraceptive, progestogen contra.in/mat. Schering (Germany)

Novinet (desogestrel + ethinyl estradiol) contraceptive, estrogen-gestagenic tabl.p.o. Gedeon Richter (Hungary)

Pauzogest (norethisterone + estradiol) estrogen-gestagenic tab.b.p.o. Gedeon Richter (Hungary)

Pencrofton tablets 0.2 g (mifepristone) antiprogestogenic tab. Pentcroft Pharma (Russia)

Postinor (levonorgestrel) contraceptive, progestogen, antiestrogen tab. Gedeon Richter (Hungary)

Primolut-Nor (norethisterone) gestagenic tab. Schering (Germany)

Provera (medroxyprogesterone) anticancer, progestogenic tab. Pharmacia (USA)

Progynova (estradiol valerate) estrogenic dragee Schering (Germany)

Regulon (desogestrel + ethinyl estradiol) contraceptive, estrogen-progestogen tab.p.o. Gedeon Richter (Hungary)

Rigevidon (levonorgestrel + ethinyl estradiol) contraceptive tab.