What are the main uses of Flausiver. How does Flausiver work in the body. What are the potential side effects of taking Flausiver. Are there any precautions to consider when using Flausiver. How does Flausiver interact with other medications. What is the recommended dosage for Flausiver. What do user reviews say about the effectiveness of Flausiver.

Understanding Flausiver: An In-Depth Overview

Flausiver, also known as hesperidin, is a plant-based compound classified as a bioflavonoid. Primarily found in citrus fruits, this natural substance has garnered attention in the medical community for its potential health benefits. But what exactly is Flausiver, and how does it work in the body?

Flausiver functions by improving blood vessel health and reducing inflammation. Its mechanism of action involves enhancing the integrity of blood vessel walls, which can lead to better circulation and reduced swelling in various parts of the body. This unique property makes Flausiver a subject of interest for treating several vascular-related conditions.

The Science Behind Flausiver’s Effects

At a molecular level, Flausiver interacts with the body’s inflammatory pathways, potentially inhibiting the production of pro-inflammatory molecules. This anti-inflammatory effect may contribute to its therapeutic potential in various conditions. Additionally, Flausiver has been observed to have antioxidant properties, which could protect cells from oxidative stress and contribute to overall health.

Primary Uses and Effectiveness of Flausiver

Flausiver has been studied for its efficacy in treating several health conditions. But for which conditions is it most effective? Let’s explore the primary uses of Flausiver and the evidence supporting its effectiveness:

• Chronic Venous Insufficiency (CVI)
• Hemorrhoids
• Venous Leg Ulcers

Flausiver for Chronic Venous Insufficiency

Chronic Venous Insufficiency is a condition where blood doesn’t flow efficiently from the legs back to the heart, often resulting in swollen legs. How effective is Flausiver in treating CVI? Studies have shown that Flausiver, especially when combined with other compounds like diosmin, can significantly improve CVI symptoms. A treatment duration of 2-6 months has been observed to yield positive results, alleviating discomfort and reducing swelling in affected individuals.

Flausiver’s Role in Hemorrhoid Treatment

Hemorrhoids, a common and often uncomfortable condition, have also been a focus of Flausiver research. Can Flausiver provide relief for hemorrhoid sufferers? Clinical studies suggest that Flausiver, particularly when used in combination with diosmin, can improve hemorrhoid symptoms. Moreover, it may help prevent recurrence after initial healing and prove beneficial during acute flare-ups.

Healing Venous Leg Ulcers with Flausiver

Venous leg ulcers, often a complication of chronic venous insufficiency, can be challenging to treat. How does Flausiver factor into the treatment of these ulcers? Research indicates that a specific product containing Flausiver and diosmin, when used in conjunction with compression dressings, can enhance the healing of small venous stasis ulcers. This combination approach has shown promise in improving healing rates and patient comfort.

Potential Side Effects of Flausiver

While Flausiver offers several potential benefits, it’s crucial to be aware of possible side effects. What are the most common side effects associated with Flausiver use?

• Stomach pain and upset
• Diarrhea
• Headache

It’s important to note that these side effects are generally mild and may not occur in all individuals. However, if you experience persistent or severe side effects, it’s advisable to consult with a healthcare professional.

Long-Term Safety Considerations

Is Flausiver safe for long-term use? Current research suggests that Flausiver is possibly safe when taken orally for up to 6 months. However, there is insufficient data to determine its safety for use beyond this period. As with any supplement or medication, long-term use should be discussed with a healthcare provider to weigh potential benefits against risks.

Important Precautions and Warnings for Flausiver Use

While Flausiver is generally considered safe for most people, there are certain situations where caution is advised. What precautions should be taken when using Flausiver?

Flausiver During Pregnancy and Breastfeeding

Is Flausiver safe for pregnant or breastfeeding women? Limited research suggests that Flausiver, when taken with diosmin, may be possibly safe for pregnant or breastfeeding women. However, due to the lack of comprehensive studies, it’s crucial to consult with a healthcare provider before using Flausiver during pregnancy or while breastfeeding.

Flausiver and Bleeding Disorders

Can Flausiver affect blood clotting? Flausiver may potentially slow blood clotting, which could theoretically increase the risk of bleeding. Individuals with bleeding disorders should exercise caution and consult their healthcare provider before using Flausiver.

Flausiver and Blood Pressure Concerns

How does Flausiver affect blood pressure? Some studies suggest that Flausiver might lower blood pressure. While this could be beneficial for some, individuals with already low blood pressure should be cautious, as Flausiver might cause blood pressure to drop too low.

Surgical Considerations

Should Flausiver be discontinued before surgery? Due to its potential effects on blood clotting, it’s recommended to stop taking Flausiver at least two weeks before any scheduled surgery. This precaution helps minimize the risk of excessive bleeding during and after surgical procedures.

Flausiver Interactions: Understanding Potential Risks

Flausiver can interact with various medications, potentially altering their effectiveness or increasing the risk of side effects. What are some key interactions to be aware of when using Flausiver?

Flausiver and Cardiovascular Medications

How does Flausiver interact with heart and blood pressure medications? Flausiver may reduce the absorption of certain medications like celiprolol and diltiazem, potentially decreasing their effectiveness. It’s crucial to avoid taking Flausiver concurrently with these medications unless under direct medical supervision.

Additionally, Flausiver might enhance the effects of blood pressure-lowering medications, potentially causing blood pressure to drop too low. Medications in this category include nifedipine, verapamil, and amlodipine, among others.

Flausiver and Drug Absorption

Can Flausiver affect how other drugs are absorbed by the body? Flausiver may influence cellular pumps responsible for drug absorption, potentially increasing the concentration of certain medications in the body. This could lead to increased side effects for drugs such as etoposide, paclitaxel, ketoconazole, and various others.

Flausiver and Blood Thinners

Is there a risk in combining Flausiver with blood-thinning medications? Given Flausiver’s potential to slow blood clotting, combining it with anticoagulant or antiplatelet drugs could increase the risk of bruising and bleeding. Caution is advised when using Flausiver alongside medications like warfarin, aspirin, or clopidogrel.

Dosing Guidelines for Flausiver

Determining the right dosage of Flausiver is crucial for maximizing its benefits while minimizing potential side effects. What are the general dosing recommendations for Flausiver?

Standard Dosage for Adults

What is the typical dose of Flausiver for adults? While dosages can vary based on the specific condition being treated, a common dosage range for Flausiver is 500-2000 mg per day, often divided into two or three doses. However, it’s important to note that optimal dosages may differ based on individual factors and the specific formulation being used.

Dosing for Specific Conditions

How does Flausiver dosing differ for various health conditions?

• For Chronic Venous Insufficiency: A typical regimen might involve 500 mg of Flausiver combined with 450 mg of diosmin, taken twice daily.
• For Hemorrhoids: During acute episodes, a higher dose of 1000 mg Flausiver with 900 mg diosmin may be recommended for the first 4 days, followed by a lower maintenance dose.
• For Venous Leg Ulcers: Dosing may be similar to that for CVI, often in conjunction with standard wound care practices.

It’s crucial to emphasize that these are general guidelines, and individual dosing should always be determined in consultation with a healthcare provider.

Duration of Treatment

How long should Flausiver be taken? The duration of Flausiver treatment can vary significantly based on the condition being treated and individual response. For chronic conditions like CVI, treatment may extend for several months, while acute conditions like hemorrhoid flare-ups might require shorter treatment periods.

User Reviews and Experiences with Flausiver

Understanding real-world experiences can provide valuable insights into the effectiveness and tolerability of Flausiver. What do users typically report about their experiences with Flausiver?

Positive Feedback

Many users report positive outcomes when using Flausiver, particularly for vascular-related conditions. Common positive experiences include:

• Reduced leg swelling and discomfort in CVI
• Improved symptoms and faster healing of hemorrhoids
• Enhanced overall leg health and circulation

Reported Challenges

While many users report benefits, some challenges have been noted:

• Mild gastrointestinal discomfort, especially at the beginning of treatment
• Variability in response time, with some users experiencing quicker results than others
• Consistency in taking the supplement, particularly for long-term conditions

Long-Term User Perspectives

Users who have taken Flausiver for extended periods often report sustained benefits, particularly in managing chronic conditions like CVI. Many emphasize the importance of combining Flausiver with lifestyle modifications, such as regular exercise and proper nutrition, for optimal results.

It’s important to note that individual experiences can vary, and while user reviews provide valuable anecdotal evidence, they should not replace professional medical advice or well-designed clinical studies.

Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Hesperidin is a plant chemical that is classified as a “bioflavonoid.” It is most commonly found in citrus fruits. People use it as medicine.

Hesperidin, alone or in combination with other citrus bioflavonoids (such as diosmin), is most commonly used for blood vessel conditions such as hemorrhoids, varicose veins, and poor circulation (venous stasis).

Hesperidin may help blood vessels function better. It may also reduce inflammation.

Uses & Effectiveness ?

Possibly Effective for

• Poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI). Taking a particular product containing hesperidin methyl chalcone, butcher’s broom, and vitamin C by mouth seems to relieve the symptoms of poor circulation in the legs. Also, taking a different product containing hesperidin and diosmin by mouth for 2-6 months seems to improve CVI symptoms, although taking the drug Venoruton might be more effective for treating this condition.
• Hemorrhoids. Some research suggests that taking hesperidin and diosmin improves symptoms of anal hemorrhoids. It may also prevent hemorrhoids from coming back after they have healed and may help in an emergency worsening of hemorrhoids.
• Leg sores caused by weak blood circulation (venous leg ulcer). Taking a specific product containing hesperidin and diosmin by mouth for 2 months seems to improve the healing of small venous stasis ulcers when used along with compression dressings.

Possibly Ineffective for

• High cholesterol. Most research shows that taking hesperidin doesn’t improve cholesterol levels.
• Obesity. Some research shows that taking glucosyl hesperidin for 12 weeks doesn’t reduce body weight in people that are slightly overweight.

Side Effects

When taken by mouth: Hesperidin is POSSIBLY SAFE for most people when taken by mouth for up to 6 months. There isn’t enough information to know if hesperidin is safe when taken for longer than 6 months. Side effects include stomach pain and upset, diarrhea, and headache.

Special Precautions and Warnings

When taken by mouth: Hesperidin is POSSIBLY SAFE for most people when taken by mouth for up to 6 months. There isn’t enough information to know if hesperidin is safe when taken for longer than 6 months. Side effects include stomach pain and upset, diarrhea, and headache. Pregnancy and breast-feeding: Hesperidin is POSSIBLY SAFE for pregnant or breast-feeding women when taken by mouth with diosmin.

Bleeding disorder: Hesperidin might slow blood clotting and increase the risk of bleeding. In theory, hesperidin might make bleeding disorders worse.

Low blood pressure: Hesperidin might lower blood pressure. In theory, taking hesperidin might make blood pressure become too low in people who already have low blood pressure.

Surgery: Hesperidin might prolong bleeding. There is concern that hesperidin might increase the risk of bleeding during and after surgical procedures. Stop taking hesperidin at least 2 weeks before a scheduled surgery.

Interactions ?

Moderate Interaction

Be cautious with this combination

• Hesperidin may reduce how much celiprolol the body absorbs. This might decrease how well celiprolol works. Do not take hesperidin with celiprolol.

• Hesperidin may reduce how much diltiazem the body absorbs. This might decrease how well diltiazem works. Do not take diltiazem with hesperidin.

• Hesperidin might decrease blood pressure. Taking hesperidin along with medications used to lower high blood pressure might cause your blood pressure to go too low.

  Some medications for high blood pressure include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.

• Some medications are moved by pumps in cells. Hesperidin might make these pumps less active and increase the amount of some medications that get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. But there is not enough information to know if this is a big concern.

  Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

• Hesperidin might slow blood clotting. Taking hesperidin along with medications that also slow blood clotting might increase the risk of bruising and bleeding and others.

• Hesperidin might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking hesperidin along with sedative medications might cause too much sleepiness. Taking hesperidin along with sedative medications used in surgery might cause prolonged sedation.

  Some sedative medications include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), thiopental (Pentothal), fentanyl (Duragesic, Sublimaze), morphine, propofol (Diprivan), and others.

• Hesperidin may increase how much verapamil the body absorbs. This might increase the effects and side effects of verapamil. Do not take verapamil with hesperidin.

Dosing

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:

• For poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI): A specific combination product containing hesperidin methyl chalcone 150 mg, butcher’s broom root extract 150 mg, and ascorbic acid 100 mg has been used. Also, a combination of 100-150 mg of hesperidin with 900-1350 mg of diosmin taken daily for 2-6 months has been used.
• For hemorrhoids: A combination of 150 mg of hesperidin plus 1350 mg of diosmin twice daily for 4 days, followed by 100 mg of hesperidin and 900 mg of diosmin twice daily for 3 days has been used. Also, a combination of 50 mg of hesperidin plus 450 mg of diosmin twice daily for 3 months has been used to prevent the return of hemorrhoids.
• For sores caused by weak blood circulation (venous leg ulcer): A combination of 100 mg of hesperidin and 900 mg of diosmin daily for up to 2 months has been used.

View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

Benefits, Dosage, Side Effects, and More

Diosmin is a flavonoid most commonly found in citrus fruits. Flavonoids are plant compounds that have antioxidant properties, which protect your body from inflammation and unstable molecules called free radicals (1, 2).

Diosmin was first isolated from the figwort plant (Scrophularia nodosa L.) in 1925 and has been used since 1969 as a natural therapy to treat various conditions, such as hemorrhoids, varicose veins, venous insufficiency, leg ulcers, and other circulatory issues (2).

It’s believed to help reduce inflammation and restore normal blood flow in people with venous insufficiency, a condition in which blood flow is impaired (2).

Today, diosmin is widely derived from another flavonoid called hesperidin, which is also found in citrus fruits — especially orange rinds (2).

Diosmin is often combined with micronized purified flavonoid fraction (MPFF), a group of flavonoids that includes disomentin, hesperidin, linarin, and isorhoifolin (3).

Most diosmin supplements contain 90% diosmin with 10% hesperidin and are labeled MPFF. In most cases, the terms “diosmin” and “MPFF” are used interchangeably (3).

This supplement is available over the counter in the United States, Canada, and some European countries. Depending on your location, it may be called Diovenor, Daflon, Barosmin, citrus flavonoids, Flebosten, Litosmil, or Venosmine (4, 5).

Diosmin is most widely used to treat blood vessel disorders, such as hemorrhoids and chronic venous insufficiency (CVI). Hemorrhoids are swollen veins located near the anus, while CVI refers to swollen, blocked veins in the legs (6, 7).

People may also take diosmin for other blood vessel disorders, including varicose veins, blood clots, retinal hemorrhage (bleeding in the retina of the eye), venous leg ulcers, and venous stasis (slow blood flow in the legs) (8, 9).

Research suggests that this compound may reduce inflammation in the veins and thus improve blood flow (2).

Hemorrhoids

Numerous studies suggest that diosmin helps treat internal and external hemorrhoids.

In a review of 24 studies in over 2,300 people, plant flavonoids like diosmin decreased hemorrhoid-related itchiness, bleeding, discharge, and other hemorrhoid symptoms (10).

Other studies reveal similar improvements in hemorrhoid symptoms. Additionally, diosmin has been shown to reduce recovery time following a hemorrhoidectomy, or surgical removal of hemorrhoids (3, 11, 12, 13).

Though these results are promising, most improvements are seen in people in the early stages of hemorrhoid disease. Overall, diosmin may not be as effective as other hemorrhoid treatments (11, 12, 14, 15).

Chronic venous disease

Chronic venous disease (CVD) is an umbrella term for conditions related to weak or diseased veins. These include CVI, varicose veins, spider veins, leg ulcers, and phlebitis — a condition in which the leg veins become swollen (16).

A 2012 review of 10 studies concluded that moderate evidence supports the use of MPFF (diosmin) to improve CVD symptoms, such as leg ulcers, edema, varicose veins, tingling sensation, general quality of life, and subjective pain ratings (16).

A 2016 review and 2018 meta-analysis supported these findings. Furthermore, they showed diosmin reduced leg heaviness, swelling, cramps, and restless leg syndrome (17, 18).

Diosmin treats CVD by reducing inflammation, improving the health of veins, and increasing blood and lymphatic circulation (3, 19, 20, 21).

Still, a 2017 study in 1,051 people noted that diosmin wasn’t as effective at treating CVD symptoms as other medications, such as Venoruton (Novartis) and Pycnogenol (pine bark extract). Other studies report similar findings (22, 23, 24).

Though diosmin may reduce symptoms of CVD, it’s best to speak to a healthcare professional before supplementing with it.

Back pain

In one study, 300 people reported minor improvements in back pain after taking 900 mg of diosmin 3 times daily for 2 weeks, followed by the same dose twice daily for 2 weeks, then a maintenance dose of 450 mg twice daily for 1 month (25).

However, compared with a control group taking mannitol and dexamethasone, diosmin was not more effective at reducing subjective back pain (25).

More research is needed to understand if diosmin aids back pain compared with more established treatments.

Other conditions

Some people take diosmin for other conditions, including lymphedema (swelling of the lymphatic system), varicocele (pain and enlargement of veins in the scrotum), minor bleeding, pelvic pain, and rosacea.

Diosmin is a known anti-inflammatory compound and may work to treat some of these inflammatory and circulation disorders.

Although small studies have shown some positive results for treating symptoms of lymphedema, varicocele, minor nasal bleeds, and pelvic pain, larger studies are needed before widespread recommendations can be made (26, 27, 28, 29).

Diosmin is generally recognized as a safe over-the-counter supplement.

Though rare, side effects of diosmin include stomach pain, diarrhea, headaches, dizziness, skin rash, hives, muscle pain, and — in severe cases — irregular heartbeat (30, 31).

If you experience any side effects after taking diosmin, discontinue use and speak with your healthcare provider. If you experience severe pain, severe diarrhea (10 or more loose stools in 24 hours), or an irregular heartbeat, seek medical attention immediately.

Diosmin is available over the counter in the United States, Canada, and certain European countries. It’s typically sold as micronized purified flavonoid fraction (MPFF), which usually contains 90% diosmin and 10% hesperidin.

The most common and well-researched supplement is Daflon 500 (450 mg diosmin, 50 mg hesperidin). It’s also known as Detralex in some regions. However, many other diosmin products are likely available in your local pharmacy and online.

Most diosmin products recommend taking one 500-mg supplement with food once in the morning and again in the evening for a total of 1,000 mg per day.

Under the guidance of a health professional, these dosage guidelines have been shown to be safe and effective for various conditions (16, 32, 33):

• Chronic venous disease: 1,000 mg per day for 3–6 months
• Hemorrhoids: 1,000–2,000 mg per day for 4 days, followed by 1,000 mg per day for 3 days
• Varicose veins: 1,000–2,000 mg per day for up to 6 months

Do not take diosmin for more than 3 months — or take more than the recommended dose on the label — unless instructed by your healthcare provider.

To date, there are no known cases of diosmin overdose or reports of toxicity.

Nonetheless, you should always follow the instructions on the label and speak to a healthcare professional to make sure it’s right for you.

Diosmin may interact with the following medications (34, 35, 36):

• anticoagulants (such as Warfarin)
• anticonvulsants (such as Carbamazepine and Phenytoin/Dilantin)
• antihistamines (such as Allegra)
• muscle relaxants (such as Chlorzoxazone)
• non-steroidal anti-inflammatory drugs (such as Voltaren, Motrin, Advil, and Aleve)
• acetaminophen (such as Tylenol)

Diosmin may inhibit various liver enzymes responsible for metabolizing the above medications. This can result in your medications working less effectively and may be dangerous for those with bleeding disorders by preventing proper blood clotting (34, 35, 36).

Diosmin may also interact with certain herbal supplements, including fenugreek, feverfew, garlic, ginger, ginkgo, ginseng, and turmeric, due to their involvement in blood thinning (34).

If you take any of these medications or supplements, be sure to speak to your healthcare provider before trying diosmin.

Be sure to store diosmin in a cool, dry environment, such as a medicine cabinet. Always read the label and avoid taking any supplements past their expiration date.

Due to a lack of safety research, women who are pregnant or breastfeeding should avoid taking diosmin.

Always speak with your healthcare provider before taking any supplements or medications.

Diosmin may worsen bleeding people with bleeding disorders. If you have any bleeding disorders, avoid this supplement unless instructed otherwise by your healthcare provider (30, 31).

Children and teenagers should avoid taking diosmin, as there is no available safety research in these age groups.

If you have any underlying conditions, such as diabetes, heart disease, and inflammatory bowel disease (IBD), it’s important to speak with a healthcare professional before taking diosmin.

Depending on your condition, a variety of other products or treatments may work as a suitable alternative to diosmin (7, 21, 37, 38):

• Hemorrhoids: high fiber diets, topical creams and suppositories, over-the-counter pain relievers (Advil, Motrin, Tylenol), prescription medications, injections, and surgical procedures like hemorrhoid removal or hemorrhoid stapling
• CVD (including varicose veins): over-the-counter pain relievers (Advil, Motrin, Tylenol), compression socks, exercise, Antistax (red vine leaf extract) or other supplements, prescription medications, sclerotherapy, laser or radiofrequency ablation, and surgical procedures like vein ligation

Though diosmin has been shown to aid these conditions, your healthcare provider may recommend a combination of treatments.