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Heparin interactions: Uses, Dosage, Side Effects, Interactions, Warning

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Heparin Interactions Checker – Drugs.com

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There are 224 drugs known to interact with
heparin, along with
7 disease interactions, and 1 alcohol/food interaction.

Of the total drug interactions,
58 are major, 143 are moderate, and 23 are minor.

Does heparin interact with my other drugs?

Enter other medications to view a detailed report.

  • View all 224 medications that may interact with heparin
  • View heparin alcohol/food interactions (1)
  • View heparin disease interactions (7)

Most frequently checked interactions

View interaction reports for heparin and the medicines listed below.

  • Major
  • Moderate
  • Minor
  • Unknown
  • Ativan (lorazepam)
  • Benadryl (diphenhydramine)
  • Cardizem (diltiazem)
  • Colace (docusate)
  • Combivent (albuterol / ipratropium)
  • Coumadin (warfarin)
  • Dilaudid (hydromorphone)
  • Eliquis (apixaban)
  • Lantus (insulin glargine)
  • Lasix (furosemide)
  • Lipitor (atorvastatin)
  • Lopressor (metoprolol)
  • Lovenox (enoxaparin)
  • MiraLAX (polyethylene glycol 3350)
  • Norco (acetaminophen / hydrocodone)
  • Normal Saline Flush (sodium chloride)
  • Norvasc (amlodipine)
  • Paracetamol (acetaminophen)
  • Percocet (acetaminophen / oxycodone)
  • Phenergan (promethazine)
  • Plavix (clopidogrel)
  • Protonix (pantoprazole)
  • Rocephin (ceftriaxone)
  • Synthroid (levothyroxine)
  • Tylenol (acetaminophen)
  • Vitamin B12 (cyanocobalamin)
  • Vitamin C (ascorbic acid)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zofran (ondansetron)

Heparin alcohol/food interactions

There is 1 alcohol/food interaction with heparin.

Heparin disease interactions

There are 7 disease interactions with heparin which include:

  • peptic ulcer disease
  • active bleeding
  • hypertension
  • prematurity
  • renal dysfunction
  • thrombocytopenia
  • hyperkalemia

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More about heparin

  • heparin consumer information
  • Compare alternatives
  • Pricing & coupons
  • Reviews (2)
  • Latest FDA alerts (18)
  • Side effects
  • Dosage information
  • Patient tips
  • During pregnancy
  • Drug class: heparins
  • Breastfeeding
  • En español

Related treatment guides

  • Angina
  • Anticoagulation During Pregnancy
  • Antiphospholipid Syndrome
  • Deep Vein Thrombosis

Drug Interaction Classification
These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
MajorHighly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
ModerateModerately clinically significant. Usually avoid combinations; use it only under special circumstances.
MinorMinimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
UnknownNo interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Heparin (Porcine) Injection: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

heparin (porcine) 1,000 unit/mL injection solution

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This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: Shape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 20,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 20,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 20,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL (1 mL) injection cartridge

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 20,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL injection solution

Color: clearShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 10,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 1,000 unit/mL injection solution

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

heparin (porcine) 5,000 unit/mL (1 mL) injection cartridge

Color: colorlessShape: Imprint:

This medicine is a colorless, clear, vial

Heparin sodium drug interactions with other drugs (compatibility) | Vidal.

ru

Heparin sodium drug interactions with other drugs (compatibility) | Vidal.ru – a directory of medicines

Effects when used simultaneously with drugs
Abciximab Risk of bleeding. With simultaneous use, monitoring of the APTT is required.
Oral anticoagulants (vitamin K antagonists) Concomitant use of oral anticoagulants and low molecular weight heparins increases the risk of bleeding due to the additive anticoagulant effect. Both heparin and warfarin prolong the aPTT and prothrombin time. This disorder is recommended to be considered taking into account the therapeutic effect, since normal coagulation values ​​do not reflect the risk of bleeding. To reduce distortion in the determination of prothrombin time due to bolus intravenous heparin, an interval of at least 5-6 hours should be observed between the last administration of heparin and blood sampling.
NSAIDs Risk of hemorrhagic complications due to simultaneous inhibition of blood coagulation and platelet aggregation. If simultaneous use cannot be avoided, then constant monitoring of the patient’s condition is required.
Dextran Increased risk of bleeding due to antithrombotic and antiplatelet properties of dextran. The combination should be avoided unless the potential benefit of therapy outweighs the risk of bleeding, in which case an appropriate dose reduction of heparin is required.
Probenecid May increase the effects of heparin under the influence of probenecid and the development of bleeding.
Salicylates It has been established that the use of acetylsalicylic acid during heparin therapy increases the risk of bleeding by 2. 5 times. Due to antiplatelet and antithrombotic properties, salicylates can potentiate the anticoagulant effect of heparin, which increases the risk of bleeding. In addition, the ulcerogenic effect of salicylates may increase the risk of bleeding from the gastrointestinal tract. The use of this combination is characterized by a high risk, therefore, if combination therapy is necessary, the expected benefit and potential risk should be carefully evaluated. If combined use is necessary, then constant monitoring of the patient’s condition is required.

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Heparin instructions for use: indications, contraindications, side effects – description of Heparin solution for injections.

5 thousand IU / ml: 1 ml or 2 ml amp. 5 or 10 pieces, 5 ml vial 5 or 50 pcs. (4363)

💊 Composition of the drug Heparin

✅ Use of the drug Heparin

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Interaction

Description of the active ingredients of the preparation

Heparin
(Heparin)

The scientific information provided is general and cannot be used to make decisions.
decisions about the use of a particular drug.

Update date: 2019.12.04

Marketing authorization holder:

SYNTHESIS JSC
(Russia)

ATX code:

B01AB01

(Heparin)

Active substance:
sodium heparin
(heparin sodium)

Rec. INN

WHO registered

Dosage form

Heparin

Injection solution 5 thousand IU / ml: 1 ml or 2 ml amp. 5 or 10 pieces, 5 ml vial 5 or 50 pcs.

reg. No.: R N000116/01
dated 01.10.07
– Indefinitely

Release form, packaging and composition
drug Heparin

5 ml – bottles (5) – packs of cardboard.
5 ml – bottles (50) – cardboard boxes.
5 ml vials.
5 ml – bottles (5) – contour plastic packaging (1) – packs of cardboard.
1 ml – ampoules (5) – blister strip packs (2) – cardboard packs.
2 ml – ampoules (5) – blister strip packs (1) – cardboard packs.
5 ml – ampoules (5) – blister strip packs (1) – cardboard packs.
5 ml – ampoules (5) – blister strip packs (2) – cardboard packs.
2 ml – ampoules (5) – blister strip packs (2) – cardboard packs.
1 ml – ampoules (5) – blister packs (1) – cardboard packs.

Clinical and pharmacological group:

Direct acting anticoagulant – medium molecular weight heparin

Pharmacotherapeutic group:

Direct acting anticoagulant

Pharmacological action

Direct acting anticoagulant belongs to the group of medium molecular weight heparins. In blood plasma, it activates antithrombin III, accelerating its anticoagulant effect. Violates the transition of prothrombin to thrombin, inhibits the activity of thrombin and activated factor X, to some extent reduces platelet aggregation.

For unfractionated standard heparin, the ratio of antiplatelet activity (anti-factor Xa) to anticoagulant activity (APTT) is 1:1.

Increases renal blood flow; increases the resistance of cerebral vessels, reduces the activity of cerebral hyaluronidase, activates lipoprotein lipase and has a hypolipidemic effect. Reduces the activity of surfactant in the lungs, suppresses excessive synthesis of aldosterone in the adrenal cortex, binds adrenaline, modulates the ovarian response to hormonal stimuli, enhances the activity of parathyroid hormone. As a result of interaction with enzymes, it can increase the activity of brain tyrosine hydroxylase, pepsinogen, DNA polymerase and reduce the activity of myosin ATPase, pyruvate kinase, RNA polymerase, pepsin.

Heparin has been shown to have immunosuppressive activity.

In patients with coronary artery disease (in combination with acetylsalicylic acid) reduces the risk of acute coronary artery thrombosis, myocardial infarction and sudden death. Reduces the frequency of recurrent heart attacks and mortality in patients with myocardial infarction. In high doses, it is effective for pulmonary embolism and venous thrombosis, in small doses it is effective for the prevention of venous thromboembolism, incl. after surgical operations.

With intravenous administration, blood coagulation slows down almost immediately, with intramuscular injection – after 15-30 minutes, with s / c – after 20-60 minutes, after inhalation, the maximum effect is after a day; the duration of the anticoagulant action, respectively, is 4-5, 6, 8 hours and 1-2 weeks, the therapeutic effect – prevention of thrombosis – lasts much longer. Deficiency of antithrombin III in plasma or at the site of thrombosis may reduce the antithrombotic effect of heparin.

Pharmacokinetics

After subcutaneous administration C max of the active substance in plasma is observed after 3-4 hours. Heparin does not penetrate the placenta well due to its large molecular weight. Not excreted in breast milk.

T 1/2 from plasma is 30-60 min.

Indications of the active substances of the drug

Heparin

Prevention and therapy: deep vein thrombosis, pulmonary embolism (including in peripheral vein diseases), coronary artery thrombosis, thrombophlebitis, unstable angina, acute myocardial infarction, atrial fibrillation (including accompanied by embolism), DIC, prevention and therapy of microthrombosis and microcirculation disorders, renal vein thrombosis, hemolytic uremic syndrome, mitral heart disease (thrombosis prevention), bacterial endocarditis, glomerulonephritis, lupus nephritis.

Prevention of blood coagulation during operations using extracorporeal methods of circulation, during hemodialysis, hemosorption, peritoneal dialysis, cytapheresis, forced diuresis, when washing venous catheters.

Preparation of non-clotting blood samples for laboratory purposes and blood transfusion.

Open list of ICD-10 codes

D59.3 Hemolytic uremic syndrome
D65 Disseminated intravascular coagulation [defibrination syndrome]
I20.0 Unstable angina
I21 Acute myocardial infarction
I26 Pulmonary embolism
I33.9 Acute endocarditis, unspecified
I34. 0 Mitral (valvular) insufficiency
I48 Atrial fibrillation and flutter
I74 Arterial embolism and thrombosis
I80 Phlebitis and thrombophlebitis
I82 Embolism and thrombosis of other veins
N00 Acute nephritic syndrome (acute glomerulonephritis)
N03 Chronic nephritic syndrome
N08.5 Glomerular lesions in systemic connective tissue diseases
Z51.4 Preparatory procedures for subsequent treatment or examination, not elsewhere classified

Dosing regimen

The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

Individual, depending on the dosage form used, indications, clinical situation and age of the patient.

Side effects

On the part of the blood coagulation system: possible bleeding of the gastrointestinal tract and urinary tract, bleeding at the injection site, in areas subjected to pressure, from surgical wounds, as well as hemorrhages in other organs, hematuria, thrombocytopenia.

From the digestive system: nausea, loss of appetite, vomiting, diarrhea, increased activity of liver transaminases.

Allergic reactions: flushing of the skin, drug fever, urticaria, rhinitis, pruritus and sensation of heat in the soles, bronchospasm, collapse, anaphylactic shock.

On the part of the blood coagulation system: thrombocytopenia (may be severe up to death) with subsequent development of skin necrosis, arterial thrombosis, accompanied by the development of gangrene, myocardial infarction, stroke.

From the musculoskeletal system: with prolonged use – osteoporosis, spontaneous fractures, soft tissue calcification.

Local reactions: irritation, pain, hyperemia, hematoma and ulceration at the injection site.

Other: transient alopecia, hypoaldosteronism.

Contraindications for use

Bleeding, diseases accompanied by impaired blood coagulation, suspected intracranial hemorrhage, cerebral aneurysm, hemorrhagic stroke, dissecting aortic aneurysm, antiphospholipid syndrome, malignant arterial hypertension, subacute bacterial endocarditis, erosive ulcerative lesions of the gastrointestinal tract , severe lesions of the liver parenchyma, cirrhosis of the liver with varicose veins of the esophagus, malignant neoplasms in the liver, shock conditions, recent surgical interventions on the eyes, brain, prostate, liver and biliary tract, condition after spinal cord puncture, menstruation, threatened miscarriage, childbirth (including recent), hypersensitivity to heparin.

Use during pregnancy and lactation

Use during pregnancy is possible only under strict indications, under close medical supervision.

Contraindication: threatened miscarriage, childbirth (including recent).

Can be used during breastfeeding if indicated.

Use for violations of liver function

Contraindications: severe lesions of the liver parenchyma, cirrhosis of the liver with varicose veins of the esophagus, malignant neoplasms in the liver.

Use for impaired renal function

Used when indicated in patients with severe kidney disease.

Use in children

May be used in children if indicated.

Use in elderly patients

Use with caution in elderly patients (over 60 years, especially in women).

Special instructions

Use with caution in patients suffering from polyvalent allergies (including bronchial asthma), arterial hypertension, dental procedures, diabetes mellitus, endocarditis, pericarditis, in the presence of an intrauterine contraceptive, with active tuberculosis, radiation therapy, liver failure, chronic renal failure, in elderly patients (over 60 years, especially women).

IM administration of heparin is not recommended due to the possibility of developing a hematoma, as well as IM administration of other drugs during treatment with heparin.

Use with caution externally for bleeding and conditions of increased bleeding, thrombocytopenia.

During treatment with heparin, monitoring of blood coagulation parameters is necessary.

Only normal saline is used to dilute heparin.

With the development of severe thrombocytopenia (a decrease in the number of platelets by 2 times from the original number or below 100,000 / µl), heparin should be urgently discontinued.

The risk of bleeding can be minimized with careful evaluation of contraindications, regular laboratory monitoring of blood clotting, and adequate dosing.

Drug interactions

The anticoagulant effect of heparin is enhanced by the simultaneous use of anticoagulants, antiplatelet agents and NSAIDs.

Ergot alkaloids, thyroxine, tetracycline, antihistamines, and nicotine reduce the effect of heparin.

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