How many trazodone can i take. Trazodone: Proper Usage, Overdose Risks, and Treatment Guidelines
How many trazodone can you safely take. What are the signs of trazodone addiction. Can you overdose on trazodone. How is a trazodone overdose treated. What is the proper use of trazodone for depression and insomnia.
Understanding Trazodone: Uses and Mechanism of Action
Trazodone is a versatile medication primarily used to treat depression, anxiety, and insomnia. It belongs to the class of drugs known as serotonin antagonists and reuptake inhibitors (SARIs). Trazodone works by increasing serotonin levels in the brain, a neurotransmitter crucial for regulating mood and sleep patterns.
In 2019, there were approximately 23,934,214 trazodone prescriptions filled, with an estimated 5,066,449 patients using the medication. This widespread use underscores the importance of understanding its proper usage and potential risks.
Off-label Uses of Trazodone
While primarily prescribed for depression and sleep disorders, trazodone has several off-label uses, including:
- Treatment of migraines
- Management of nerve pain
- Anxiety disorders
These additional applications highlight the drug’s versatility in addressing various mental health and neurological conditions.
Trazodone Dosage and Administration
The appropriate dosage of trazodone varies depending on the individual’s specific condition, age, weight, and overall health. Typically, doctors start patients on a low dose and gradually increase it to achieve the desired therapeutic effect.
Standard Dosage Guidelines
What is the typical dosage range for trazodone? The standard dose of trazodone for adults usually ranges from 50 to 100 mg per day. However, in some cases, doctors may prescribe higher doses, up to 300 mg daily, divided into multiple administrations.
It’s crucial to follow your healthcare provider’s instructions precisely and never adjust your dosage without consulting them first. Trazodone is available in various forms, including immediate-release and extended-release tablets.
The History and Development of Trazodone
Trazodone has an interesting history dating back to the early 1960s. Originally developed as an antipsychotic medication, researchers discovered its potent antidepressant properties during clinical trials. This serendipitous finding led to its reclassification and eventual approval as an antidepressant.
How does trazodone compare to other antidepressants? Clinical studies have shown that trazodone’s efficacy is comparable to other antidepressant classes, including:
- Tricyclic antidepressants (TCAs)
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs)
One notable advantage of trazodone is its better tolerability profile compared to second-generation SSRIs, which are often associated with side effects like insomnia, anxiety, and sexual dysfunction.
Recognizing Trazodone Addiction and Misuse
While trazodone is not classified as a controlled substance, it can still be habit-forming in some individuals. Recognizing the signs of trazodone addiction is crucial for preventing misuse and potential overdose.
Signs of Trazodone Addiction
What are the indicators that someone may be developing a trazodone addiction? Look out for the following signs:
- Taking higher doses or using the medication more frequently than prescribed
- Continuing to use trazodone even when it’s no longer medically necessary
- Experiencing intense cravings or urges to use the drug
- Neglecting important responsibilities or activities in favor of using trazodone
- Persisting in trazodone use despite negative consequences, such as relationship problems or job loss
If you or someone you know exhibits these signs, it’s essential to seek professional help promptly. Addiction specialists can provide appropriate treatment options and support for overcoming trazodone dependence.
Trazodone Overdose: Risks and Symptoms
Can you overdose on trazodone? Yes, it is possible to overdose on trazodone, and such incidents can be life-threatening. The risk of overdose increases when trazodone is taken in higher doses than prescribed or combined with other substances that enhance its effects.
Symptoms of Trazodone Overdose
Recognizing the signs of a trazodone overdose is crucial for seeking timely medical intervention. Common symptoms include:
- Severe drowsiness or difficulty staying awake
- Confusion and disorientation
- Seizures
- Irregular or slowed heartbeat
- Dizziness or fainting due to low blood pressure
If you suspect a trazodone overdose, it’s imperative to seek emergency medical attention immediately by calling 911 or your local poison control center.
Factors Influencing Trazodone Overdose Risk
Several factors can increase the risk of trazodone overdose, making it essential for patients and healthcare providers to be aware of potential interactions and contraindications.
Drug Interactions and Overdose Risk
What medications can increase the risk of trazodone overdose? Combining trazodone with certain substances can amplify its effects and increase the likelihood of adverse reactions. These include:
- Other antidepressants, particularly MAOIs
- Antihistamines
- Sedatives and sleep aids
- Opioid pain relievers
- Muscle relaxants
- Alcohol
It’s crucial to inform your healthcare provider about all medications, supplements, and substances you’re using to minimize the risk of dangerous interactions.
Treatment Approaches for Trazodone Overdose
In the event of a trazodone overdose, prompt medical intervention is essential to prevent severe complications and ensure the best possible outcome.
Emergency Interventions
How is a trazodone overdose treated? The primary goals of treatment are to stabilize the patient’s vital signs and manage specific symptoms. Common interventions may include:
- Gastric lavage or activated charcoal administration to remove unabsorbed medication from the stomach
- Intravenous fluids to maintain blood pressure and support organ function
- Cardiac monitoring and treatment of arrhythmias if present
- Administration of benzodiazepines to control seizures
- Use of specific antidotes or medications to counteract trazodone’s effects on serotonin levels
The exact treatment approach will depend on the severity of the overdose, the amount of trazodone ingested, and the presence of any co-ingested substances.
Preventing Trazodone Overdose: Safe Usage Guidelines
Preventing trazodone overdose begins with proper medication management and adherence to prescribed dosages. Here are some essential guidelines for safe trazodone use:
- Always follow your doctor’s instructions regarding dosage and administration
- Never increase your dose without consulting your healthcare provider
- Avoid combining trazodone with alcohol or other central nervous system depressants
- Store trazodone in a secure location, out of reach of children and pets
- Dispose of unused medication properly to prevent accidental ingestion
- Be aware of potential side effects and report any concerns to your doctor promptly
By adhering to these guidelines, patients can significantly reduce the risk of trazodone overdose and ensure safe, effective treatment for their conditions.
Long-term Effects and Considerations of Trazodone Use
While trazodone can be an effective treatment for depression and sleep disorders, it’s important to consider the potential long-term effects of its use.
Potential Side Effects
What are the most common side effects of long-term trazodone use? While individual experiences may vary, some potential side effects include:
- Daytime drowsiness or fatigue
- Dry mouth
- Blurred vision
- Weight changes
- Sexual dysfunction
- Dizziness or lightheadedness
It’s important to discuss any persistent or concerning side effects with your healthcare provider to determine if adjustments to your treatment plan are necessary.
Discontinuation and Withdrawal
How should one approach discontinuing trazodone treatment? Abruptly stopping trazodone can lead to withdrawal symptoms, such as anxiety, irritability, and sleep disturbances. To minimize these effects, doctors typically recommend a gradual tapering of the medication under medical supervision.
The tapering process allows the body to adjust to decreasing levels of the drug, reducing the likelihood of experiencing severe withdrawal symptoms. The duration and specific approach to tapering will depend on factors such as the length of treatment, dosage, and individual patient characteristics.
Alternative Treatments and Complementary Approaches
While trazodone can be an effective treatment for depression and sleep disorders, some individuals may seek alternative or complementary approaches to manage their symptoms.
Non-Pharmacological Interventions
What are some alternative treatments for depression and insomnia that can complement or replace trazodone use? Consider the following options:
- Cognitive-behavioral therapy (CBT)
- Mindfulness meditation and relaxation techniques
- Regular exercise and physical activity
- Light therapy for seasonal affective disorder
- Acupuncture and other traditional Chinese medicine practices
- Herbal supplements (consult with a healthcare provider before use)
It’s important to note that while these approaches can be beneficial, they should be pursued under the guidance of a qualified healthcare professional, especially when considering changes to an existing treatment plan.
Combining Treatments
In many cases, a combination of pharmacological and non-pharmacological interventions may provide the most comprehensive approach to managing depression and sleep disorders. This integrative strategy can address multiple aspects of the condition, potentially leading to better overall outcomes and improved quality of life.
Always consult with your healthcare provider before making any changes to your treatment plan or incorporating new therapies. They can help you develop a personalized approach that takes into account your specific needs, medical history, and treatment goals.
Can you Overdose on Trazodone?
Overdosing on trazodone can be dangerous and even deadly. In this article, we’ll discuss what Trazadone is, how it can lead to an overdose, and what to do if someone overdoses on Trazadone.
Trazadone is a medication that is used to treat:
- Depression
- Anxiety
- Insomnia
It can also be an f-label treatment for migraines and nerve pain. Trazodone works by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that helps regulate mood.
The amount of Trazadone that is necessary to overdose depends on a number of factors, including the person’s weight, age, and health. A typical dose of Trazodone ranges from 50 to 100 mg. However, it is possible to overdose on much lower doses.
What Is Trazadone and How Is it Used?
Trazodone is an antidepressant medication that is used to treat major depressive disorders. It can also be used to treat anxiety, insomnia, and pain. Trazodone is a serotonin antagonist and reuptake inhibitor (SARI). This means that it prevents the reabsorption of serotonin, which increases the level of serotonin in the brain.
In 2019, there were a total of 23,934,214 Trazodone prescriptions. There was an estimated 5,066,449 Trazodone patients.
Trazodone is available as a generic drug and as the brand-name drugs Desyrel and Oleptro. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name versions.
How Was Trazodone Created?
Trazodone was created in the early 1960s. It was originally designed as an antipsychotic medication. However, it was found to be more effective as an antidepressant.
Trazodone is available in oral tablet form. It’s typically taken one to three times a day. The dose depends on your medical condition and response to treatment. Your doctor may start you on a low dose of trazodone and gradually increase your dose, not more than once every 3 or 4 days.
Clinical studies have shown trazodone to be comparable in efficacy to other drug classes, such as:
- TCAs (tricyclic antidepressants)
- SSRIs (selective serotonin reuptake inhibitors)
- SNRIs (serotonin-norepinephrine receptor inhibitors) in treating major depressive disorders.
Also, trazodone has better tolerance than second-generation SSRIs, which are highly associated with insomnia, anxiety, and sexual dysfunction
What Are the Signs of Trazodone Addiction?
Trazodone can be habit-forming. You can develop a tolerance to the drug, meaning you need higher and higher doses to get the same effect. Misusing trazodone can lead to addiction, overdose, or death.
Trazodone is a prescription medication. It’s not available over-the-counter (OTC). You should take trazodone only as directed by your doctor. Your doctor will probably start you on a low dose and increase your dose gradually.
Some signs that a person may be addicted to trazodone include:
- Taking the drug more often or in higher doses than prescribed
- Continuing to take the drug even if it’s no longer needed
- Craving the drug or feeling an intense urge to use it
- Neglecting other important activities in favor of using the drug
- Using the drug despite negative consequences, such as relationship problems or job loss
If you think you or someone you know may be addicted to trazodone, talk to a doctor or reach out to our California-based rehab center.
They can help identify whether there’s a problem and recommend treatment options.
What Is a Drug Overdose?
A drug overdose occurs when a person takes more of a medication than their body can safely process. Overdoses can be intentional or accidental. They can also be life-threatening and require medical attention immediately. If you or a loved one is overdosing on medication or a drug, dial 9-11 immediately.
Can a Person Overdose on Trazodone?
If you take too much trazodone, you may experience a drop in blood pressure, which can cause dizziness or fainting. An overdose of trazodone can be fatal.
Symptoms of a Trazodone overdose can include:
- Drowsiness
- Confusion
- Seizures
- Slowed or irregular heartbeat
If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 911 or go to the nearest emergency room immediately.
Overdosing on trazodone is more likely if you’re taking other medications that can cause drowsiness or affect your heart rhythm.
These include:
- Other antidepressants
- Antihistamines
- Sedatives
- Pain relievers, and muscle relaxants
- Taking alcohol with trazodone
How Much Trazodone is Necessary to Overdose?
An overdose of trazodone can be fatal. The amount of trazodone that can lead to an overdose varies from person to person. However, taking more than 500 mg of trazodone at once can cause an overdose in most people. This is why you should always take medication as instructed by a medical professional.
How Is an Overdose Treated?
Overdoses of trazodone are treated with supportive care. This can include:
- Monitoring vital signs
- Providing oxygen
- Giving IV fluids
- Pumping the stomach (if the person has taken the medication within the last hour)
Treatment Options for Trazodone Use
There are many treatment options for drug addiction. Treatment can be done on an inpatient or outpatient basis, depending on the severity of the addiction.
Treatment typically includes behavioral therapy, medication, and support groups. In some cases, detoxification may be necessary.
Treatment should be tailored to the individual, as every person’s experience with addiction is unique. If you or someone you know is struggling with drug addiction, there are many resources available to help.
Amount, Symptoms, Risks, Treatment & More
Trazodone overdoses are possible but uncommon. Learn about how these overdoses occur, their symptoms and how to help someone experiencing an overdose.
Trazodone is commonly used as a prescription antidepressant. Its brand names include medications like Oleptro and Desyrel. In addition to treating depression, trazodone can be used to treat anxiety disorders and even insomnia. The drug is sometimes used as an alternative to traditional sedatives, such as benzodiazepines.
When taken in excess and in ways not directed by a licensed physician, trazodone and other antidepressants can lead to negative side effects.
In serious instances, an overdose on trazodone may occur.
Can You Overdose on Trazodone?
Trazodone overdoses are uncommon, but they are still possible. However, an overdose of this drug is different from what many would expect. Almost every single overdose that originates from trazodone use has occurred in patients who were prescribed the drug. This is because trazodone has no perceived recreational value for a person looking to achieve a high. Using excess amounts of trazodone simply speeds up and boosts the medication’s drowsiness effect. This separates it from many other drugs, including opioids or hallucinogens, with overdoses frequently or solely caused by recreational use.
The danger of a trazodone overdose lies in taking more than one’s prescribed dose. Like many antidepressants, a patient may take more of the drug than they should to rid themselves of depressive symptoms and thoughts. Many of these types of overdoses are unintentional in nature. However, some may be premeditated attempts by patients who overuse the prescription for self-harm purposes.
How Much Trazodone to Overdose?
Doctors often recommend a daily dose of 150 mg of trazodone for depression treatment. This amount can be increased to upward of 600 mg if necessary. Much lower doses are used to treat insomnia. As such, any amount exceeding 600 mg in 24 hours is considered an overdose.
The actual dosage needed to fatally overdose on trazodone is not readily available. A large proportion of deaths linked to the antidepressant were due to mixing other substances with trazodone. Alcohol seems to be a particularly dangerous combination and should be avoided entirely.
Related Topic: Trazodone for Sleep
Trazodone Overdose Symptoms
An overdose on trazodone is characterized by any number of life-threatening symptoms. Each indicator is linked to a specific region of the body:
- Respiratory system: Respiratory depression is a common side effect exhibited during trazodone overdoses. It occurs when the lungs do not properly expand and contract.
Breathing may cease momentarily or stop completely during such an episode. - Central nervous system: Trazodone acts upon the central nervous system directly for its medical benefits. Therefore, a majority of symptoms tie directly to the brain. These symptoms include drowsiness, headache, uncoordinated behavior, dizziness, seizures and coma.
- Cardiovascular system: Irregular heartbeat (arrhythmia), low blood pressure, faint pulse and chest pain are additional side effects caused by antidepressant overdoses.
Breathing may cease momentarily or stop completely during such an episode.Trazodone Overdose Treatment
Like overdoses for most drugs, treatment related to trazodone begins at the site of the incident. If you, a loved one or a stranger is showing onset symptoms of an overdose, the best course of action is to contact poison control and 911.
Be prepared to give an accurate account of the scenario. This includes information about the victim’s age, weight and height. Additionally, it is helpful to know how much of the trazodone was ingested and in what specific time period.
At the hospital, victims can expect mostly preventative and symptom-specific care. There is no antidote for a trazodone overdose — time is the only treatment. Physicians may choose to administer intubation to promote proper breathing or a dose of activated charcoal to decontaminate the patient’s stomach contents. Nearly all trazodone overdoses are manageable with immediate treatment efforts.
If you or a loved one is struggling with substance misuse, The Recovery Village is here to help. Contact us today to learn about treatment programs that can work well for your needs.
Editor – Jonathan Strum
Jonathan Strum graduated from the University of Nebraska Omaha with a Bachelor’s in Communication in 2017 and has been writing professionally ever since. Read more
Medically Reviewed By – Dr. Conor Sheehy, PharmD, BCPS, CACP
Dr. Sheehy completed his BS in Molecular Biology at the University of Idaho and went on to complete his Doctor of Pharmacy (PharmD) at the University of Washington in Seattle.
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Healthline. “Trazodone, Oral Tablet.” November 15, 2018. Accessed June 10, 2020.
MedlinePlus. “Trazodone Overdose.” April 25, 2019. Accessed June 10, 2020.
Medical Disclaimer
The Recovery Village aims to improve the quality of life for people struggling with substance use or mental health disorder with fact-based content about the nature of behavioral health conditions, treatment options and their related outcomes. We publish material that is researched, cited, edited and reviewed by licensed medical professionals. The information we provide is not intended to be a substitute for professional medical advice, diagnosis or treatment. It should not be used in place of the advice of your physician or other qualified healthcare providers.
💊 Ingredients of Trittiko ✅ Use of Trittiko Keep for yourself Search for analogues Interaction Description of the active ingredients of the preparation Trittiko The scientific information provided is general and cannot be used to make decisions. Update date: 2020.05.29 Marketing authorization holder: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A. ATX code: N06AX05 (Trazodone) Active substance: Rec.INN WHO registered Dosage form
Release form, packaging and composition |
(45130)
C.R.A.F., S.p.A.
Increases the depth and duration of sleep in depressed patients, restores its physiological structure.
Plasma protein binding – 89-95%.
Decreased libido, impotence. Prevention of migraine attacks.| F10.3 | Withdrawal state |
| F13 | Mental and behavioral disorders due to the use of hypnotics or sedatives |
| F31 | Bipolar affective disorder |
| F32 | Depressive episode |
| F33 | Recurrent depressive disorder |
| F40 | Phobic anxiety disorders (including agoraphobia, social phobias) |
| F41.1 | Generalized anxiety disorder |
| F41.2 | Mixed anxiety and depressive disorder |
F41. 9 | Anxiety disorder, unspecified |
| F50.2 | Bulimia nervosa |
| F52.0 | Lack or loss of sexual desire |
| F52.2 | Lack of genital response (psychogenic impotence) |
| F63.2 | Pathological desire to steal [kleptomania] |
| G43 | Migraine |
Dosage regimen
The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.
The initial daily dose is 150-200 mg (in 3 divided doses). In mild forms of depression, the average maintenance dose is 150 mg / day; in moderate and severe forms – 300 mg / day. If necessary, the dose can be increased to 600 mg / day. The main part of the daily dose is recommended to be taken at bedtime.
Side effects
From the side of the central nervous system and peripheral nervous system: drowsiness, fatigue, dizziness, insomnia, headache, agitation, myalgia, impaired coordination of movements, paresthesia, disorientation, blackout, tremor.
From the side of the cardiovascular system: arrhythmia, conduction disorders, bradycardia, ventricular fibrillation, decreased blood pressure, orthostatic hypotension, syncope.
From the digestive system: nausea, vomiting, diarrhea, dryness and bitterness in the mouth.
On the part of the organ of vision: blurred vision, eye irritation.
From the side of the hematopoietic system: leukopenia, neutropenia (usually minor).
Other: nasal congestion, priapism followed by impotence, allergic reactions.
Contraindications
Ventricular arrhythmia, tachycardia, myocardial infarction (early recovery period), history of priapism, pregnancy, lactation, hypersensitivity to trazodone.
Use during pregnancy and lactation
Use during pregnancy and lactation is contraindicated.
Use in hepatic dysfunction
Use with caution in hepatic impairment.
Use in impaired renal function
Use with caution in renal insufficiency.
Use in children
Use with caution in children and adolescents under 18 years of age.
Special instructions
Use with caution in heart disease, arterial hypotension, arterial hypertension, renal and / or liver failure, in children and adolescents under the age of 18 years.
Do not use concomitantly with MAO inhibitors.
Drug interactions
A case of development of torsades de pointes arrhythmia with simultaneous use of trazodone with amiodarone is described.
A case of a moderate decrease in the anticoagulant effect of warfarin has been described when co-administered with trazodone.
With simultaneous use, an increase in the concentration of digoxin in the blood plasma and the development of symptoms of intoxication are possible.
When used simultaneously with carbamazepine, a case of increased plasma concentrations of carbamazepine has been described.
When used simultaneously with lithium salts, tremors, reversible symptoms of neurotoxic action are possible.
When taking pseudoephedrine against the background of trazodone therapy, a case of anxiety, panic, blackout, depersonalization was described.
With simultaneous use with thioridazine, an increase in the concentration of trazodone in the blood plasma is possible; with tryptophan – a case of development of anorexia, psychosis, hypomania is described; with phenytoin – a case of increased side effects of phenytoin is described; with fluoxetine – possibly increased side effects; with chlorpromazine, trifluoperazine – the development of arterial hypotension is possible.
When used simultaneously with ethanol, the inhibitory effect on the central nervous system increases.
Keep
If you want to place a link to the description of this drug – use this code
Trittiko . Description of the drug in the reference book Vidal.
Trazodone (Trazodonum) – PsyAndNeuro.ru
Trade names in Russia
Trittiko, Azona
Presentation
Tablets: 150 mg
Contents
Pharmacologist serotonin receptor antagonist [2]
Indications
◊ Recommendations of the Russian Ministry of Health
F32 Depressive episode
F52 Sexual dysfunction not due to an organic disorder or disease
R52.2 Other persistent pain
Y47.1 Adverse reactions to benzodiazepine therapy
Z50.2 Alcoholism rehabilitation
Z50.
3 Drug Rehabilitation
◊ FDA guidelines
Depression
◊ UK Medicines and Healthcare Products Regulatory Agency guidelines
- Anxiety
- Depression
Target symptoms
- Depression
- Anxiety
- Insomnia
Mechanism of action and pharmacokinetics
Trazodone, being a derivative of triazolopyridine, has the ability to selectively inhibit the reuptake of serotonin in the brain, the drug acts as an antagonist of 5-HT2A / 2C receptors. It does not have an anticholinergic effect, does not inhibit MAO.
- After oral administration, absorption from the gastrointestinal tract is high.
- Time to reach Cmax max in blood plasma – 1-2 hours
- Half-life: 1st phase 3-6 hours, 2nd phase 5-9 hours
- The isoenzymes CYP3A4, CYP3A5 and CYP3A7 are involved in metabolism.
Treatment regimen
0351
◊ How fast
- In some patients with insomnia, with the correct dosage, it starts to work immediately.
- Depression begins to act after 2-4 weeks.
- If there is no effect after 6-8 weeks, increase the dose or switch to another drug.
- May be taken for many years to prevent relapse.
◊ Expected result
- In the treatment of depression: complete remission.
- After the disappearance of symptoms of depression, you should continue taking 1 year if it was the treatment of the first episode. If this is a re-episode treatment, treatment can be extended indefinitely.
- Use in the treatment of anxiety may be indefinite.
- For insomnia, use may be indefinite because there is no evidence of tolerance, dependence, or withdrawal [1].
◊ If not working
- Change dose, switch to another drug, or add an ancillary drug;
- Connect psychotherapy;
- Review diagnosis for comorbid conditions;
- Patients with undiagnosed bipolar affective disorder may have poor response, in which case switching to a Mood Stabilizer [1].
◊ How to stop taking
It is possible to reduce the dose gradually, although there is no evidence of a withdrawal syndrome [1].
◊ Therapeutic combinations
- Trazodone is rarely used as monotherapy for insomnia, in severe cases it can be combined with benzodiazepines
- Trazodone is the most common drug in combination with antidepressants, it not only treats insomnia, but also enhances the antidepressant effect
Warnings and contraindications
- Stop taking if erection becomes unusually long – there is a risk of erectile dysfunction;
- If erection lasts more than 1 hour, seek immediate medical attention;
- Use caution if patient has had convulsions;
- Use caution if patient has bipolar disorder;
- Do not use if allergic to trazodone [1].
Special groups of patients
◊ Patients with diseased kidneys
Special dose selection is not required [1].
◊ Patients with diseased liver
With caution [1].
◊ Heart patients
- May cause arrhythmia.
- Monitor patient closely.
- Not recommended after a heart attack.
◊ Elderly patients
Elderly patients are more likely to experience side effects.
◊ Children and teenagers
- The patient’s condition should be checked regularly and personally, especially during the first weeks of treatment.
- Inform adults of the risks.
- Start with low doses.
- Boys are at higher risk of priapism than adult men
◊ Pregnant
- Not recommended for pregnant women, especially during the first trimester
- All risks should be weighed and compared
- Bleeding can be expected at delivery
◊ Breastfeeding
- The drug passes into breast milk.
- If the infant shows signs of irritation or sedation, stop feeding or taking sertraline
- However, postpartum treatment may be necessary and the risks should be weighed.
Interaction with other substances
- Tramadol increases the risk of seizures when taken with antidepressants
- Do not use with MAO inhibitors. After the end of taking MAO inhibitors, 14 days should pass. Start treatment with MAO inhibitors 7 days after the end of taking vortioxetine.
- Trazodone may reduce the effect of antihypertensive drugs [1].
Tests during treatment
Not required.
Side effects and other risks
◊ Mechanism of side effects
- Sedation likely due to antihistamine properties 903 51
- Most side effects occur immediately after starting treatment and go away with time.
◊ Side effects
- Nausea, vomiting, constipation, dry mouth
- Sedation, fatigue, headache
- Reduced pressure
- Dangerous side effects : rarely priapism, rarely convulsions, rarely mania, rarely suicidal ideation
- Weight gain : rare
- Sedation : often
- Sexual dysfunction: no
◊ Dealing with side effects
- Wait
- If severe sedation, take at night
- Change drug [1]
◊ Long term use
Safe
◊ Habituation 9 0316
No.