What forms of ibuprofen are available?

Ibuprofen is a drug that comes in a variety of forms, including:

• Tablets is the most common form of ibuprofen and is available in various strengths. They are easy to take and quickly begin to act.
• Capsules is another form of ibuprofen that may be helpful for those who have difficulty swallowing tablets.
• Syrups and solutions is a form of ibuprofen that is suitable for children as it is easier to swallow in liquid form and tastes better.
• Sprays and Gels is a form of ibuprofen that can be applied topically to the skin in areas of pain.

The choice of ibuprofen formulation may depend on the purpose of administration, patient preference and age.

Doses of ibuprofen tablets and capsulesDose Example drug names

Always check with your doctor or pharmacist to find the right dosage and formulation of ibuprofen.

How to take ibuprofen correctly?

Ibuprofen is a drug widely used to relieve pain and fever. However, to fully benefit from its use, you must follow these recommendations:

1. Dosage. The dosage of ibuprofen depends on the age, weight and health of the patient. Do not exceed the maximum recommended dose indicated on the drug packaging.
2. Application. Ibuprofen should be taken after meals to avoid gastrointestinal irritation. The tablets should be taken with water.
3. Reception frequency. Ibuprofen may be repeated no more than 4-6 hours apart. It is not recommended to use the drug for more than 5 days without a pause.

Failure to follow the recommendations for the use of ibuprofen can lead to serious consequences, including damage to the gastrointestinal tract and impaired kidney function.

Remember to consult your doctor before starting any medication, especially if you have any chronic medical conditions.

What dosages of ibuprofen are needed to treat different diseases?

Ibuprofen is an effective and widely used drug that helps relieve pain and reduce inflammation. The choice of dosage and duration of ibuprofen administration depends on the type of disease and its severity.

For the treatment of mild pain, including headache, menstrual pain and toothache, a dose of 200-400 mg of ibuprofen is usually sufficient for adults and children over 12 years of age. For children under 12 years of age, it is recommended to consult a pediatrician.

In the treatment of severe pain such as migraine, arthritis and Raynaud’s disease, ibuprofen dosages may be higher – about 600-800 mg per day for adults and 400-600 mg per day for children.

It is important to remember that increasing the dose and duration of ibuprofen can lead to side effects, so always follow the instructions for the drug and do not exceed the recommended dose without consulting your doctor.

How long can I take ibuprofen and what are its side effects?

Ibuprofen is one of the most effective and widely used drugs in medicine. It is used to eliminate pain and reduce temperature in various diseases. But how long can you take ibuprofen?

To stop pain or reduce fever, ibuprofen should be taken as soon as symptoms appear. Ibuprofen is usually taken for no more than 7 days.

It is important to know that overdosing ibuprofen can lead to unwanted side effects that can be hazardous to your health.

• High dosage may lead to the risk of gastroenterological complications.
• With prolonged use of the drug may affect the function of the kidneys and liver.
• At high doses and long-term use, there is a risk of bleeding in the body.

If you experience symptoms associated with ibuprofen use, you should contact your doctor immediately. He will diagnose and warn you of dangerous consequences.

Important to know: before self-administration of ibuprofen, be sure to consult a specialist!

What are the contraindications for the use of ibuprofen?

Ibuprofen is one of the most popular pain medications. But, like any medicine, it has its contraindications. For the safe use of ibuprofen, it is necessary to be aware of the existing counter-indications.

Colds and flu: The use of ibuprofen for flu and colds is not recommended as it may worsen symptoms and make breathing difficult.

Pregnancy and breastfeeding: Do not use ibuprofen during the first and third trimesters of pregnancy. You should also avoid using the drug during breastfeeding to avoid side effects on the baby.

Aspirin hypersensitivity: People with aspirin hypersensitivity may experience an allergic reaction to ibuprofen

Anti-clotting drugs: Ibuprofen may reduce the effectiveness of anti-clot drugs, which can lead to serious illness.

Kidney failure: If you have kidney problems, you should limit the use of ibuprofen, as it can cause deterioration of the kidneys and harm your health.

The use of ibuprofen must be deliberate and necessary. If you are not sure if you can take this drug, you should consult your doctor.

Can ibuprofen be taken during pregnancy and breastfeeding?

Ibuprofen is not recommended during pregnancy or while breastfeeding without medical advice. While general purpose ibuprofen is considered safe for healthy adults, there may be higher risks and side effects in pregnant women and infants.

The fact is that taking ibuprofen during the first trimester of pregnancy may increase the risk of heart defects in the fetus. In the second and third trimesters, taking ibuprofen can lead to a delay in the onset of labor and increased bleeding during labor.

When breastfeeding, ibuprofen may pass into breast milk and cause side effects in the infant. This may include gastrointestinal disturbances, allergic reactions, and kidney problems.

However, in some cases, a doctor may prescribe ibuprofen to a pregnant or breastfeeding woman to treat pain, inflammation, and fever. In such cases, you should follow the doctor’s recommendations and take the drug in accordance with the instructions for it.

How does ibuprofen interact with other drugs?

Ibuprofen is an anti-inflammatory and pain reliever often used in combination with other medicines. However, when using several drugs at the same time, unwanted interactions are possible, which can lead to serious consequences.

If you are taking other medicines, be sure to check with your doctor or pharmacist to avoid potential problems.

Drugs that ibuprofen may interact with include:

• Aspirin
• Glucocorticosteroids
• Anticoagulants
• Anticonvulsants
• Diabetes drugs

Also, do not take ibuprofen with alcohol, as this may increase negative side effects and increase the risk of stomach ulcers or bleeding.

It is important to remember that self-medication can be dangerous to health, so before using ibuprofen or any other medicine, you should consult your doctor.

Why is ibuprofen the preferred analgesic for patients with gastric ulcers?

When you suffer from pain or inflammation, you are looking not only for an effective, but also a safe way to relieve your symptoms. In this regard, ibuprofen is one of the best analgesics and anti-inflammatory drugs, especially if you have stomach problems.

Ibuprofen belongs to a group of non-steroidal anti-inflammatory drugs (NSAIDs) that block prostaglandin, a hormone that can cause pain and inflammation. Unlike other NSAIDs such as aspirin and nezaproxen, ibuprofen only targets prostaglandin blockers when pain and inflammation increase, reducing the risk of stomach ulcers and other side effects.

Ibuprofen is also rapidly excreted from the body, which reduces the time of drug exposure to the stomach and reduces the likelihood of side effects with long-term use.

If you already have stomach problems, ibuprofen is your best choice for an analgesic and anti-inflammatory drug. And for those who have not yet experienced stomach ulcers, ibuprofen is also an effective remedy for relieving pain and inflammation.

What complications can occur with long-term use of ibuprofen?

Ibuprofen is one of the most popular non-steroidal anti-inflammatory drugs. It has a powerful anti-inflammatory, analgesic and antipyretic effect. However, with long-term use of ibuprofen, some complications may occur, which must be taken into account when treating it with drugs.

The first and most common complication associated with long-term use of ibuprofen is damage to the gastric mucosa. Stomach acid can damage the walls of the stomach, leading to ulcers and bleeding. Since ibuprofen reduces the overall protection of the gastric mucosa, as a result of its use, the risk of developing these complications increases.

The second possible complication is kidney damage. Long-term use of ibuprofen can lead to the development of nephrotoxicity, which is characterized by damage to the structural units of the kidneys. This process can lead to the development of chronic kidney failure, which can be difficult to cure.

The third complication to consider when using ibuprofen is liver damage. The use of ibuprofen may be at high risk of developing hepatotoxicity, which may lead to impaired liver function. This may be due to the fact that ibuprofen destroys liver cells, which provide protection from toxic substances and other negative factors.

Finally, a fourth possible complication to consider with long-term ibuprofen use is skin reactions. Sometimes ibuprofen can cause an allergic reaction, which is manifested by a skin rash, itching and swelling. If you observe signs of an allergic reaction, stop using ibuprofen immediately and consult your doctor.

Remember that long-term use of any drug requires caution. If you are considering long-term use of ibuprofen, please consult with your doctor to evaluate the possible risks and side effects.

What advantages does ibuprofen have over other analgesics?

Ibuprofen is one of the most popular analgesics and anti-inflammatory drugs and has several advantages over other drugs:

• Starts faster: Ibuprofen takes effect within 30 minutes after ingestion, while other analgesics take 1 to 2 hours to start working.
• Fewer side effects: When used correctly, ibuprofen has fewer side effects than most other analgesics.
• OTC: Ibuprofen is available from pharmacies without a prescription, while some analgesics require a prescription.
• For a wide range of uses: Ibuprofen helps to manage many types of pain, including headache, muscle pain, joint pain and menstrual pain.

However, be aware that ibuprofen may have contraindications and may not be suitable for everyone. Before use, consult a doctor and strictly follow the instructions for use.

When choosing an analgesic, keep in mind that ibuprofen is a safe, effective and affordable treatment for pain and inflammation.

How can I buy ibuprofen in a pharmacy?

Ibuprofen is a medicine used to relieve pain and reduce fever. It is available in various forms – tablets, capsules, syrups and ointments. To buy ibuprofen in a pharmacy, you need to know its name and dosage that is suitable for your case.

To buy ibuprofen, go to your nearest over-the-counter pharmacy. However, if you want to buy it in bulk, then you may need prescriptions from your doctor. Before buying, it is recommended to consult a pharmacist, who will be a reliable source of information about the product and help determine the required dosage and form of release.

Avoid buying ibuprofen in the left market as it is a product that can be extremely harmful to your health and cause serious side effects if not taken as directed by a doctor.

Buying ibuprofen in a pharmacy, you can be sure of its high quality and get qualified information about its use and contraindications from a pharmacist. It is also possible to choose the required dosage and form of release with different prices.

Is it possible to replace folk remedies with ibuprofen?

Ibuprofen is a drug often used to reduce pain, inflammation, and fever. However, some people prefer to use more natural treatments. But can folk remedies be replaced with ibuprofen?

In some cases, folk remedies can help relieve painful symptoms. However, some conditions may be too severe or require faster response, so ibuprofen may be more effective in these situations.

However, there are several folk remedies that can help you cope with pain. For example, ginger root contains antioxidants and substances that may have an anti-inflammatory effect. In addition, herbs such as mint leaves, oak bark, and turmeric can also help relieve pain.

If you decide to replace ibuprofen with traditional remedies, be sure to consult with your doctor to make sure that the treatment you choose is safe for your body. And remember that in some cases, medication may be necessary, so do not stop taking the medication prescribed by your doctor.

How do I use ibuprofen to treat migraine?

Migraine is a chronic disease accompanied by headache attacks. In migraine sufferers, headaches are so severe that they can make it difficult to work and daily life.

Ibuprofen is widely used in the treatment of migraine. This is a drug that reduces pain and eliminates inflammation. It is effective in the treatment of migraine, especially if taken in the early stages of an attack.

For adults, the dosage of ibuprofen for the treatment of migraine is 200-400 mg at a time, not more than 3 times a day. It is important not to take ibuprofen more than once every 4 hours and not to exceed the allowed daily dose.

In the treatment of migraine, ibuprofen can be combined with other drugs, such as paracetamol or aspirin.

Taking ibuprofen may have a number of contraindications, including diseases of the gastrointestinal tract, an allergic reaction to the drug, and others. Before starting treatment, it is necessary to consult a doctor and undergo regular examinations.

The use of ibuprofen for the treatment of migraine can greatly improve the lives of patients and prevent the consequences of the disease.

How do I use ibuprofen for arthritis and arthrosis?

Ibuprofen is one of the most popular and effective analgesics for the treatment of arthritis and arthrosis. It can significantly reduce pain and inflammation in the joints, which greatly improves the quality of life of patients.

For the correct and safe use of ibuprofen in the treatment of arthritis and arthrosis, there are a few important points to consider:

• Dosage: The dosage of ibuprofen should be prescribed by your doctor based on your age, weight and medical condition. Do not exceed recommended doses;
• Duration of use: ibuprofen is usually taken for no more than 7-10 consecutive days without a break;
• Combination with other drugs: possible interactions of ibuprofen with other drugs should be considered;
• Contraindications: check for contraindications to ibuprofen, eg gastric ulcer, bronchial asthma and other diseases;
• Side effects: Some people may experience side effects such as nausea, vomiting, dizziness and other discomfort. If you experience side effects while taking ibuprofen, be sure to contact your doctor.

Ibuprofen is an effective and convenient way to relieve the pain and inflammation of arthritis and arthrosis. By following simple rules, ibuprofen can be used safely and effectively.

Q&A:

What is ibuprofen and what is it used for in medicine?

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that has analgesic, antipyretic and anti-inflammatory effects. It is used medically to relieve pain, reduce fever and reduce inflammation in various diseases and conditions such as headaches, toothaches, arthritis, injuries, etc.

How long does ibuprofen last and how often can it be taken?

The duration of action of ibuprofen depends on the formulation of the drug and the individual characteristics of the organism. Typically, the action of ibuprofen begins 30 minutes – 1 hour after ingestion and lasts from 4 to 8 hours. The frequency of administration and dosage depend on the disease and are recommended by the doctor or you should follow the instructions for the drug.

Can ibuprofen be taken while pregnant or breastfeeding?

Ibuprofen is contraindicated during pregnancy, especially during the first and third trimesters, as it may harm the fetus. In addition, ibuprofen can pass into breast milk and adversely affect the baby. Therefore, it is recommended to consult a doctor during this period.

What are the possible side effects of taking ibuprofen?

When taking ibuprofen, side effects such as nausea, vomiting, headache, dizziness, allergic reactions, abdominal pain, etc. may occur. In addition, long-term use cannot only cause the development of ulcers and bleeding in the gastrointestinal tract.

What are the contraindications for ibuprofen?

Ibuprofen is contraindicated in ulcerative diseases of the gastrointestinal tract, hemorrhagic diathesis, decompensated heart failure, kidney and liver diseases, hematopoietic disorders, as well as in cases of hypersensitivity to the drug.

Can ibuprofen be taken with other medicines?

The combined use of ibuprofen with certain drugs may increase or decrease their effect, as well as the development of unwanted side effects. Therefore, before using ibuprofen along with other medicines, you should consult your doctor.

What if I overdose ibuprofen and have a reaction?

If you have overdosed on ibuprofen and you experience reactions such as nausea, vomiting, headache, dizziness, you should immediately consult a doctor or call an ambulance. In case of bleeding or other severe reactions, you should immediately contact a medical facility.

Ibuprofen: instruction, price, analogues | Lekhim

Ibuprofen – NSAID

Ibuprofen – This is a widely prescribed NSAID, is considered one of the safest drugs in this group and is generally well tolerated, but, nevertheless, can rarely cause clinically significant and serious acute damage liver. Ibuprofen has anti-inflammatory, analgesic and antipyretic effects.

The drug is prescribed for the symptomatic treatment of various types of pain, including headache, toothache, dysmenorrhea, neuralgia, back pain, joint pain, muscle pain, rheumatic pain, as well as signs of SARS and influenza. Ibuprofen is given alone or in combination with other analgesics, antihistamines, or anticholinergics, usually at doses of 200, 400, 600, or 800 mg. Pediatric formulations of this drug are also available from pharmacies. Ibuprofen is part of many combined drugs for the symptomatic treatment of dysmenorrhea, headache, allergies, and acute respiratory viral infections.

Ibuprofen. FDA Approved Indications

Ibuprofen is indicated and FDA approved for the symptomatic treatment of inflammatory diseases and rheumatoid arthritis. Ibuprofen was discovered in the search for an alternative non-corticosteroid treatment for rheumatoid arthritis. This disease was the impetus for the creation of the substance that eventually became known as ibuprofen. Patented as 2-(4-isobutylphenyl)propionic acid (ibuprofen) by Dr. Stuart Adams and John Nicholson, it has become and remains one of the most widely used NSAIDs in the world (Halford G.M. et al., 2012). Today, ibuprofen is used as a monotherapy for the symptomatic treatment of pain in rheumatoid arthritis and inflammatory diseases, with some research being conducted into the introduction of new treatments or dosage forms. One of these studies includes the creation of complex drugs based on NSAIDs and a carbonic anhydrase inhibitor for the symptomatic treatment of pain in rheumatoid arthritis (Akgul O. et al., 2018).

Ibuprofen is FDA approved for symptomatic use in mild to moderate pain. As an over-the-counter drug, it is used as a symptomatic treatment for muscle strain, joint pain, migraine, sore throat, SARS / influenza. Postoperative pain is one type of pain. One randomized, double-blind study demonstrated the therapeutic efficacy of i.v. ibuprofen, with i.v. acetaminophen being the comparator. The effectiveness of drugs was compared in the treatment of postoperative pain in patients undergoing laparoscopic cholecystectomy. As a result of the study, in the first 24 hours after the procedure, it was found that with intravenous ibuprofen therapy, the severity of pain decreases and thus it is possible to reduce the dose of opioids (Ekinci M. et al., 2019). Ibuprofen is widely used as an effective drug for the symptomatic treatment of pain, but research is constantly aimed at improving the effectiveness of its clinical use.

Ibuprofen is also FDA-approved as an antipyretic drug used to reduce body temperature in both adults and children. NSAIDs are much more commonly used in the treatment of fever in children, and much current research is focused on making ibuprofen more effective for this purpose.

Dysmenorrhea is a disease characterized by pain during menstruation, which can vary. Dysmenorrhea can be either primary, which is usually mediated by prostaglandin production during ovulation, or secondary to another disease such as endometriosis or pelvic inflammatory disease (Durain D., 2004). NSAIDs are often the therapeutic choice and are FDA approved for the treatment of primary dysmenorrhea. Transdermal drug delivery has been a topic of research in the context of the use of ibuprofen for the symptomatic treatment of primary dysmenorrhea. One study examined the use of essential oils as penetration enhancers for the transdermal delivery of ibuprofen in patients with dysmenorrhea. As a result of the study, one of the essential oils (Chuanxiong oil) was found to have a positive effect on the permeability and relief of pain symptoms when administered with ibuprofen hydrogel (Chen J. et al., 2015).

Ibuprofen and other NSAIDs are also FDA approved for the treatment of osteoarthritis. The results of a comparative study of celecoxib (a group of coxibs) and ibuprofen demonstrated the same tolerability and efficacy in the treatment of patients with osteoarthritis of the knee (Gordo A.C. et al., 2015).

Ibuprofen has been studied for the symptomatic treatment of gout attacks. In 1978, a study by Schweitz et al. reported rapid improvement and reduction in pain in 10 patients with acute gouty arthritis (patients were treated with ibuprofen 2400 mg) (Schweitz M.C. et al., 1978). Ibuprofen is usually used as monotherapy for mild attacks and colchicine as therapy for moderate to severe gout attacks.

NSAIDs and colchicine are also often used in combination in the treatment of pericarditis due to the anti-inflammatory and analgesic properties of NSAIDs. Since 2011, ibuprofen has been one of the most widely used NSAIDs in the treatment of pericarditis. Its efficacy has been demonstrated in the CORP and CORP-2 trials in the treatment and prevention of multiple relapses of idiopathic pericarditis compared to acetylsalicylic acid. The study found no significant difference between the two drugs in the treatment or prevention of idiopathic pericarditis (Schwier N. et al., 2017). In a 2014 review, colchicine was shown to be effective in reducing the incidence of recurrent pericarditis when used as add-on therapy to NSAIDs such as ibuprofen, acetylsalicylic acid, or indomethacin, but with limited study numbers (Bayes-Genis A. et al. , 2017).

Intravenous ibuprofen has been approved by the FDA for the treatment of patent ductus arteriosus in preterm infants. As a result of studies, a similar efficacy of ibuprofen with indomethacin was recorded in this pathology. Differences exist in the incidence of systemic vasoconstriction and renal toxicity; probably due to the lower selectivity for COX-1, ibuprofen was found to have reduced rates of both outcomes (Ferguson J.M., 2019).

Since 2007, USPSTF guidelines recommend the use of acetylsalicylic acid and NSAIDs for the prevention of colorectal cancer in certain populations. In 2016, they updated these recommendations, as well as recommendations from 2009 on the use of acetylsalicylic acid and NSAIDs in the prevention of cardiovascular diseases (Bibbins-Domingo K. et al., 2016). Although these recommendations do not apply specifically to ibuprofen, they do provide a solid basis for research that confirms the potentially great role of NSAIDs in the treatment and prevention of cancer. The results of a study on the effectiveness of NSAIDs in the treatment of cancer, as well as some studies on the effectiveness of ibuprofen, have shown promising results. A review by Hil’ovska et al documented the potential use of NSAIDs in reducing the growth, morphology, and invasion of cancer cells; in the induction of cancer cell death and in the use of a lower dose of cytotoxic drugs (Hiľovská L. et al., 2015). The reviewed studies were mainly devoted to COX-2 inhibitors. With regard to ibuprofen specifically, some studies have suggested that it has a stronger antitumor effect compared to acetylsalicylic acid, namely in studies conducted in the treatment of breast and lung cancer (Harris R. E. et al., 2005). Also, when using ibuprofen or acetylsalicylic acid, the risk of developing breast cancer is reduced (Cuzick J. et al., 2009).

Similar to previous authors, Wawro et al in their studies demonstrated potential indications for the use of NSAIDs, especially acetylsalicylic acid and ibuprofen, in cancer therapy in patients with colorectal cancer treated with vincristine monotherapy. The proposed role of NSAIDs is primarily to prevent chemoresistance by inhibiting the proliferation of cancer-associated fibroblast formation. Vincristine stimulates the growth of cancer-associated fibroblasts through the secretion of tumor growth factors beta (TGF-β) and IL-6; when using acetylsalicylic acid and ibuprofen, scientists recorded an inhibitory effect of the drug on this pathological process. Their studies were based on the assumption that the probable mechanism of this inhibitory effect is associated with NSAIDs that affect the rate of regulation of microtubule polymerization dynamics (Wawro M. E. et al., 2019).

Ibuprofen. Pain in the pediatric population

Pain is a common symptom in children. For more than 30 years, the use of ibuprofen in the pediatric population has been the subject of research. The scientific literature has reviewed information on childhood illnesses over the past 20 years, drawing conclusions about the efficacy and side effects associated with the use of ibuprofen as an analgesic. Ibuprofen has been effective in several pain conditions in children such as musculoskeletal pain, ear pain and acute otitis media, toothache and inflammatory diseases of the mouth and throat. The drug is a reasonable and effective alternative for postoperative pain, including tonsillectomy and adenoidectomy. It also remains the choice in the symptomatic treatment of pain in chronic inflammatory diseases such as arthritis. Side effects associated with ibuprofen are minor. It has the lowest gastrointestinal toxicity among NSAIDs, although some cases of GI toxicity (gastrointestinal toxicity) may occur. Adverse reactions from the kidneys are minimal, but dehydration plays an important role in the occurrence of kidney damage, so ibuprofen should not be prescribed to patients with vomiting and diarrhea. Ibuprofen therapy has demonstrated a good safety profile and evidence of efficacy in the symptomatic treatment of mild to moderate pain in children of various backgrounds. The analgesic effect of NSAIDs such as ibuprofen is mainly to inhibit the biosynthesis of prostaglandins. A decrease in the synthesis of prostaglandins leads to a decrease in the production of glutathione and renal perfusion.

Advantage of ibuprofen and acetaminophen combined/alternating

Benefits of using NSAIDs and acetaminophen simultaneously or alternately have been suggested due to their potential synergy of antinociceptive effects, as well as the convenience of using an additional analgesic drug for pain that is not amenable to monotherapy at any dose of age. In acetaminophen, C _max in plasma is reached after 30 minutes compared to 60 minutes for ibuprofen. In studies of antipyretic effects, acetaminophen maximally reduces high body temperature after 2 hours, and ibuprofen after 3 hours. The recommended dosing intervals are every 6 and 8 hours for acetaminophen and ibuprofen, respectively; thus, theoretically, they can be rotated every 3 hours. Short-term use of an alternating dosing regimen may be considered for the symptomatic treatment of pain that is not relieved by monotherapy (Massimo Barbagallo et al., 2019)

There are several randomized controlled trials of symptomatic treatment of headache in children. They concluded that only ibuprofen and sumatriptan were significantly more effective than placebo in reducing headache severity.

One Cochrane review included 27 pediatric randomized controlled trials of NSAIDs. Each of them compared the therapeutic efficacy of one of the drugs in this group with placebo. Efficacy was evaluated 2 hours after administration of the study drug. Based on a systematic review, ibuprofen appeared to be more effective, making it the drug of choice for the symptomatic treatment of headache. If migraine is suspected, NSAIDs and triptans should be considered. In case of nausea and vomiting, antiemetics and IV rehydration should be used (Raucci U., 2019).

Conclusions. Ibuprofen – safety profile among NSAIDs

Ibuprofen first appeared on the market about 50 years ago and quickly became a popular drug. In April 2019, the National Agency for the Safety of Medicines and Health Products (ANSM) of France issued a warning against the use of NSAIDs in patients with infectious diseases, based on an analysis of 20 years of real data on the safety of ibuprofen and ketoprofen. Nevertheless, ibuprofen remains the basic drug used in the symptomatic treatment of pain of various origins, which is clearly confirmed in numerous randomized clinical trials and clinical experience. There is a review of the literature on the safety of ibuprofen and how it compares favorably with other NSAIDs. Ibuprofen therapy is characterized by adverse reactions not only from the gastrointestinal tract, which are dose-dependent and are especially characteristic for a certain patient population.