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Is adderall an maoi: Combining Stimulants and Monoamine Oxidase Inhibitors: A Reexamination of the Literature and a Report of a New Treatment Combination

Combining Stimulants and Monoamine Oxidase Inhibitors: A Reexamination of the Literature and a Report of a New Treatment Combination

1. Klein RG, Mannuzza S, Olazagasti MA, et al. Clinical and functional outcome of childhood attention-deficit/hyperactivity disorder 33 years later. Arch Gen Psychiatry. 2012;69(12):1295–1303. [PMC free article] [PubMed] [Google Scholar]

2. Kessler RC, Adler L, Barkley R, et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry. 2006;163(4):716–723. [PMC free article] [PubMed] [Google Scholar]

3. Goodman D. Adult ADHD and comorbid depressive disorders: diagnostic challenges and treatment options. CNS Spectr. 2009;14(suppl 6):5–7. discussion 13–14. [PubMed] [Google Scholar]

4. Sobanski E. Psychiatric comorbidity in adults with attention-deficit/hyperactivity disorder (ADHD) Eur Arch Psychiatry Clin Neurosci. 2006;256(suppl 1):i26–31. [PubMed] [Google Scholar]

5. Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder results from the National Comorbidity Survey Replication (NCS-R) JAMA. 2003;289(23):3095–3105. [PubMed] [Google Scholar]

6. Volkow ND, Swanson JM. Clinical practice: adult attention deficit-hyperactivity disorder. N Engl J Med. 2013;369(20):1935–1944. [PMC free article] [PubMed] [Google Scholar]

7. Moriyama TS, Polanczyk GV, Terzi FS, et al. Psychopharmacology and psychotherapy for the treatment of adults with ADHD: a systematic review of available meta-analyses. CNS Spectr. 2013;18(6):296–306. [PubMed] [Google Scholar]

8. Israel JA. Remission in depression: definition and initial treatment approaches. J Psychopharmacol. 2006;20(suppl 3):5–10. [PubMed] [Google Scholar]

9. Rush AJ, Trivedi MH, Wisniewski SR, et al. Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report. Am J Psychiatry. 2006;163(11):1905–1917. [PubMed] [Google Scholar]

10. Petersen T, Papakostas GI, Posternak MA, et al. Empirical testing of two models for staging antidepressant treatment resistance. J Clin Psychopharmacol. 2005;25(4):336–341. [PubMed] [Google Scholar]

11. Fava M, Rush AJ. Current status of augmentation and combination treatments for major depressive disorder: a literature review and a proposal for a novel approach to improve practice. Psychother Psychosom. 2006;75(3):139–153. [PubMed] [Google Scholar]

12. Krishnan KR. Revisiting monoamine oxidase inhibitors. J Clin Psychiatry. 2007;68(suppl 8):35–41. [PubMed] [Google Scholar]

13. McGrath PJ, Stewart JW, Fava M, et al. Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report. Am J Psychiatry. 2006;163(9):1531–1541. quiz 1666. [PubMed] [Google Scholar]

14. Henkel V, Mergl R, Allgaier AK, et al. Treatment of depression with atypical features: a meta-analytic approach. Psychiatry Res. 2006;141(1):89–101. [PubMed] [Google Scholar]

15. Shulman KI, Herrmann N, Walker SE. Current place of monoamine oxidase inhibitors in the treatment of depression. CNS Drugs. 2013;27(10):789–797. [PubMed] [Google Scholar]

16. Shulman KI, Fischer HD, Herrmann N, et al. Current prescription patterns and safety profile of irreversible monoamine oxidase inhibitors: a population-based cohort study of older adults. J Clin Psychiatry. 2009;70(12):1681–1686. [PubMed] [Google Scholar]

17. Horwitz D, Lovenberg W, Engelman K, et al. Monoamine oxidase inhibitors, tyramine and cheese. JAMA. 1964;188(13):1108–1110. [PubMed] [Google Scholar]

18. Flockhart DA. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: an update. J Clin Psychiatry. 2012;73(suppl 1):17–24. [PubMed] [Google Scholar]

19. Balon R, Mufti R, Arfken CL. A survey of prescribing practices for monoamine oxidase inhibitors. Psychiatr Serv. 1999;50(7):945–947. [PubMed] [Google Scholar]

20. Wimbiscus M, Kostenko O, Malone D. MAO inhibitors: risks, benefits, and lore. Cleve Clin J Med. 2010;77(12):859–882. [PubMed] [Google Scholar]

21. Jessen L, Kovalick LJ, Azzaro AJ. The selegiline transdermal system (emsam): a therapeutic option for the treatment of major depressive disorder. P T. 2008;33(4):212–246. [PMC free article] [PubMed] [Google Scholar]

22. Iqbal MM, Basil MJ, Kaplan J, et al. Overview of serotoin syndrome. Ann Clin Psychiatry. 2012;24(4):310–318. [PubMed] [Google Scholar]

23. Lloyd JTA, Walker DRH. Death after combined dexamphetamine and phenelzine. BMJ. 1965;2(5454):168–169. [PMC free article] [PubMed] [Google Scholar]

24. Kriskó I, Lewis E, Johnson JE., III Severe hyperpyrexia due to tranylcypromine-amphetamine toxicity. Ann Intern Med. 1969;70(3):559–564. [PubMed] [Google Scholar]

25. Feighner JP, Herbstein J, Damlouji N. Combined MAOI, TCA, and direct stimulant therapy of treatment-resistant depression. J Clin Psychiatry. 1985;46(6):206–209. [PubMed] [Google Scholar]

26. Fawcett J, Kravitz HM, Zajecka JM, et al. CNS stimulant potentiation of monoamine oxidase inhibitors in treatment-refractory depression. J Clin Psychopharmacol. 1991;11(2):127–132. [PubMed] [Google Scholar]

27. Sovner R. Amphetamine and tranylcypromine in treatment-resistant depression. Biol Psychiatry. 1990;28(11):1011–1012. [PubMed] [Google Scholar]

28. Myronuk LD, Weiss M, Cotter L. Combined treatment with moclobemide and methylphenidate for comorbid major depression and adult attention-deficit/hyperactivity disorder. J Clin Psychopharmacol. 1996;16(6):468–469. [PubMed] [Google Scholar]

29. Shelton Clauson A, Elliott ES, Watson BD, et al. Coadministration of phenelzine and methylphenidate for treatment-resistant depression. Ann Pharmacother. 2004;38(3):508. [PubMed] [Google Scholar]

30. Feinberg SS. Combining stimulants with monoamine oxidase inhibitors: a review of uses and one possible additional indication. J Clin Psychiatry. 2004;65(11):1520–1524. [PubMed] [Google Scholar]

31. Bodner RA, Lynch T, Lewis L, et al. Serotonin syndrome. Neurology. 1995;45(2):219–223. [PubMed] [Google Scholar]

32. Thomas SJ, Shin M, McInnis MG, et al. Combination therapy with monoamine oxidase inhibitors and other antidepressants or stimulants: strategies for the management of treatment-resistant depression. Pharmacotherapy. 2015;35(4):433–449. [PubMed] [Google Scholar]

33. Asnis GM, Henderson MA. EMSAM (deprenyl patch): how a promising antidepressant was underutilized. Neuropsychiatr Dis Treat. 2014;10:1911–1923. [PMC free article] [PubMed] [Google Scholar]

34. Goodnick PJ. Seligiline transdermal system in depression. Expert Opin Pharmacother. 2007;8(1):59–64. [PubMed] [Google Scholar]

35. Robinson DS, Amsterdam JD. The selegiline transdermal system in major depressive disorder: a systematic review of safety and tolerability. J Affect Disord. 2008;105(1–3):15–23. [PubMed] [Google Scholar]

36. Klein DF, Arden PC, Peter C. Early development of monoamine oxidase inhibitors. Psychiatr Ann. 2014;44(12):563–566. [Google Scholar]

37. Azzaro AJ, VanDenBerg CM, Ziemniak J, et al. Evaluation of the potential for pharmacodynamic and pharmacokinetic drug interactions between selegiline transdermal system and two sympathomimetic agents (pseudoephedrine and phenylpropanolamine) in healthy volunteers. J Clin Pharmacol. 2007;47(8):978–990. [PubMed] [Google Scholar]

38. Harris DS, Everhart T, Jacob P, 3rd, et al. A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion. BMC Clin Pharmacol. 2009;9(1):13. [PMC free article] [PubMed] [Google Scholar]

39. Kalász H, Magyar K, Szőke É, et al. Metabolism of selegiline [(-)-deprenyl)] Curr Med Chem. 2014;21(13):1522–1530. [PubMed] [Google Scholar]

40. Pennick M. Absorption of lisdexamfetamine dimesylate and its enzymatic conversion to d-amphetamine. Neuropsychiatr Dis Treat. 2010;6:317–327. [PMC free article] [PubMed] [Google Scholar]

41. Shulman KI, Walker SE. A reevaluation of dietary restrictions for irreversible monoamine oxidase inhibitors. Psychiatr Ann. 2001;31(6):378–384. [Google Scholar]

Adderall and interactions: Supplements, alcohol, and more

Adderall (amphetamine/dextroamphetamine) is a brand-name oral capsule that’s prescribed for attention deficit hyperactivity disorder (ADHD) and narcolepsy. Adderall has interactions with certain drugs, foods, and supplements. Examples include TUMS (an antacid) and lithium.

An interaction occurs when one substance causes another substance to have a different effect than expected.

Keep reading to learn more about Adderall’s interactions. For additional information about Adderall, including details about its uses, see this article.

In some cases, a factor or condition could prevent your doctor from prescribing Adderall due to the risk of harm. This is known as a contraindication. The contraindications of Adderall include the ones mentioned below.

If you have a serious heart or blood vessel problem. Taking Adderall can increase your heart rate and blood pressure. If you have a serious heart or blood vessel problem, the side effects could lead to a heart attack or stroke. The side effects could also, in rare cases, lead to sudden death. In addition, Adderall could make your condition worse. Examples of serious heart and blood vessel problems include:

  • moderate to severe hypertension (high blood pressure)
  • advanced arteriosclerosis (hardening of the arteries)
  • heart disease that causes symptoms such as chest pain or shortness of breath

If you have hyperthyroidism. Taking Adderall can increase your heart rate and blood pressure. Hyperthyroidism (an overactive thyroid gland) can also cause these symptoms. If you have hyperthyroidism, Adderall could worsen your symptoms.

If you have glaucoma. Adderall can increase the pressure in your eyes. If you have glaucoma, taking Adderall could worsen your condition.

If you have had an allergic reaction to Adderall or any of its ingredients. If you’ve had an allergic reaction to Adderall or any of its ingredients, taking the drug could cause such a reaction. You could also have an allergic reaction with Adderall if you’ve had such a reaction to other drugs called amphetamines. (Adderall is a type of amphetamine.)

If you’re in an agitated state. If you’re in an agitated state, taking Adderall could worsen it. Agitation refers to feeling restless, nervous, or annoyed. Sometimes it can be due to a mental health condition.

If you have a history of drug misuse or dependence. Adderall has a risk of misuse and dependence. If you’ve misused or been dependent on drugs in the past, you may have an increased risk of these problems with Adderall. In fact, the drug has a boxed warning about this risk. This is a serious warning from the Food and Drug Administration (FDA). To learn more, see “Boxed warning: Risk of misuse and dependence” at the top of this article.

If you have recently taken a monoamine oxidase inhibitor drug. Monoamine oxidase inhibitors (MAOIs) are an older class of antidepressant drugs. Adderall typically should not be taken within 14 days of taking an MAOI drug. Doing so can cause dangerous side effects, including kidney failure, heart attack, and unsafe rises in blood pressure.

If you’ve taken an MAOI recently, be sure to let your doctor know. They may still prescribe Adderall. However, they’ll likely have you wait at least 14 days from your last dose of the MAOI before you start Adderall treatment.

To learn more, see “Drug interactions in depth” below.

Note: Before you start treatment with Adderall, it’s important to tell your doctor if any of these factors apply to you. They can determine whether to prescribe Adderall.

Adderall may interact with alcohol. For example, drinking alcohol with Adderall can reduce the effects of alcohol, so you may drink more than you usually would. This can have dangerous results, such as loss of consciousness.

Drinking alcohol while taking Adderall may also increase the risk of certain side effects of the drug. These can include increased blood pressure and a fast or irregular heartbeat. Such side effects can increase your risk of a heart attack or stroke.

Drinking alcohol can also worsen symptoms of attention deficit hyperactivity disorder (ADHD), which Adderall treats.

If you drink alcohol, talk with your doctor about how much is safe to drink with Adderall. However, in general, it’s safest to avoid drinking alcohol while you take the medication.

Before you start treatment with Adderall, tell your doctor and pharmacist which prescription, over-the-counter, and other medications you take. By sharing this information with them, you may help prevent possible interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Here’s a chart of drugs that can interact with Adderall. Keep in mind that this chart does not include all drugs that may interact with Adderall. Some of these interactions are described in detail below in “Drug interactions in depth.”

Drug class or drug nameDrug examplesInteraction result with Adderall
monoamine oxidase inhibitors (MAOIs)*• isocarboxazid (Marplan)
• linezolid (Zyvox)
• phenelzine (Nardil)
• selegiline (Emsam, Zelapar)
• tranylcypromine (Parnate)
can cause dangerous side effects
tricyclic antidepressants (TCAs)• amitriptyline
• desipramine (Norpramin)
• imipramine (Tofranil)
can increase the risk of serotonin syndrome and heart-related side effects from Adderall
selective serotonin reuptake inhibitors (SSRIs)• citalopram (Celexa)
• escitalopram (Lexapro)
• fluoxetine (Prozac)
• fluvoxamine (Luvox)
• paroxetine (Paxil, Brisdelle, Pexeva)
• sertraline (Zoloft)
can increase the risk of serotonin syndrome
serotonin noradrenaline reuptake inhibitors (SNRIs)• desvenlafaxine (Pristiq)
• duloxetine (Cymbalta)
• venlafaxine (Effexor XR)
can increase the risk of serotonin syndrome
triptans• almotriptan
• eletriptan (Relpax)
• frovatriptan (Frova)
• naratriptan (Amerge)
• rizatriptan (Maxalt, Maxalt-MLT)
• sumatriptan (Imitrex, Tosymra, others)
can increase the risk of serotonin syndrome
lithium (Lithobid)can increase the risk of serotonin syndrome
buspirone†can increase the risk of serotonin syndrome
mirtazapine (Remeron)can increase the risk of serotonin syndrome
certain opioids• fentanyl (Subsys, Fentora, Lazanda, Actiq)
• tramadol (ConZip, Ultram, Qdolo)
can increase the risk of serotonin syndrome
cytochrome p450 2D6 (CYP2D6) inhibitors• fluoxetine (Prozac)
• paroxetine (Paxil, Brisdelle, Pexeva)
• quinidine
• ritonavir (Norvir)
can increase the risk of side effects from Adderall
antacids• calcium carbonate (TUMS)
• sodium bicarbonate (Alka-Seltzer)
• magnesium hydroxide/calcium carbonate (Rolaids)
can increase the risk of side effects from Adderall
h3 blockers• cimetidine (Tagamet HB)
• famotidine (Pepcid AC)
• nizatidine (Axid)
• ranitidine (Zantac)
can increase the risk of side effects from Adderall
urinary alkalinizers• acetazolamidecan increase the risk of side effects from Adderall
proton pump inhibitors• esomeprazole (Nexium)
• lansoprazole (Prevacid)
• omeprazole (Prilosec)
• pantoprazole (Protonix)
• rabeprazole (Aciphex)
can make Adderall less effective than usual
bupropion (Wellbutrin SR, Wellbutrin XL)can increase the risk of seizures

* To learn more, see “When to avoid Adderall” above.
† Buspar, a brand-name version of buspirone, used to be available but has been discontinued.

Here’s a closer look at certain drug interactions with Adderall.

Serotonergic drugs

Serotonergic drugs are drugs that increase levels of the chemical serotonin in your body.

Interaction result. Increased risk of serotonin syndrome.

Interaction explained. Adderall and serotonergic drugs can increase levels of serotonin in your body. Taking Adderall with a serotonergic drug can cause your serotonin level to rise too much, leading to serotonin syndrome.

Examples of serotonergic drugs. Here are some serotonergic drugs:

  • selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine (Prozac)
  • serotonin noradrenaline reuptake inhibitors (SNRIs), such as venlafaxine (Effexor XR)
  • tricyclic antidepressants, such as amitriptyline
  • certain other antidepressants, such as mirtazapine (Remeron)
  • triptans for migraine, such as sumatriptan (Imitrex)
  • the anxiety drug buspirone
  • lithium (Lithobid)
  • certain opioids, such as fentanyl (Subsys, Fentora, Lazanda, Actiq)

Steps you or your doctor may take. If you take Adderall with a serotonergic drug, your doctor may prescribe a dosage of Adderall that’s lower than usual. See your doctor right away if you have symptoms of serotonin syndrome while taking Adderall with a serotonergic drug.

Symptoms of serotonin syndrome can include dry mouth, dilated pupils, hallucinations, and sweating more than usual. Other symptoms can include a very high body temperature, stiff muscles, and delirium (sudden confusion about what’s real).

Monoamine oxidase inhibitors

Adderall has a serious interaction with drugs called monoamine oxidase inhibitors (MAOIs). These include MAOI antidepressants, and certain drugs for Parkinson’s disease or infections.

Interaction result. Risk of dangerous side effects.

Interaction explained. Taking Adderall with an MAOIcan cause a hypertensive crisis (a dangerous increase in blood pressure), heart attack, or stroke. The drug combination can also cause serotonin syndrome. This is a serious condition caused by a buildup of the chemical serotonin in your body. (To learn about symptoms of serotonin syndrome, see “Serotonergic drugs” above.)

Examples of MAOI drugs. Here are some MAOIs:

  • isocarboxazid (Marplan)
  • linezolid (Zyvox)
  • methylene blue (ProvayBlue)
  • phenelzine (Nardil)
  • selegiline (Emsam, Zelapar)
  • tranylcypromine (Parnate)

Steps you or your doctor may take. Adderall typically should not be taken within 14 days of taking an MAOI drug. If you’ve taken an MAOI recently, be sure to let your doctor know. They may still prescribe Adderall. However, they’ll likely have you wait at least 14 days from your last dose of the MAOI before starting Adderall treatment.

Acid-reducing drugs

Acid-reducing drugs reduce the level of acid in your stomach. The medications are used to treat conditions such as indigestion, heartburn, or stomach ulcers.

Interaction result. Increased risk of side effects from Adderall.

Interaction explained. Acid-reducing drugs can increase the absorption of Adderall into your body. This can raise the level of Adderall in your blood, which can make side effects from Adderall more likely.

Examples of acid-reducing drugs. Here are some acid-reducing drugs:

  • antacids, such as calcium carbonate (TUMS)
  • h3 blockers, such as famotidine (Pepcid AC)
  • proton pump inhibitors, such as esomeprazole (Nexium)

Steps you or your doctor may take. If you take Adderall with an acid-reducing drug, your doctor may prescribe a dosage of Adderall that’s lower than usual. Also, keep in mind that you should not take antacids at the same time of day as Adderall.

Adderall may have other interactions, such as with supplements, herbs, or foods. You’ll find details below.

Adderall interactions with supplements

Before you start treatment with Adderall, tell your doctor and pharmacist which supplements, herbs, and vitamins you take. By sharing this information with them, you may help prevent possible interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Adderall interaction with supplements

Certain supplements can raise the level of the chemical serotonin in your body. Taking Adderall with one of these supplements can increase your risk of serotonin syndrome. This is a serious condition caused by a buildup of serotonin in your system.

Examples of these supplements include tryptophan and 5-HTP (5-hydroxytryptophan).

Adderall interactions with herbs

An herb called St. John’s wort can increase the level of serotonin in your body. Taking Adderall with St. John’s wort can increase your risk of serotonin syndrome.

Adderall interactions with vitamins

Taking Adderall with vitamin C can reduce the absorption of Adderall into your body. This could make Adderall less effective than usual. You should take vitamin C and Adderall at least 1 hour apart.

Adderall interactions with food

Adderall has stimulant effects. If you consume caffeine with Adderall, this may increase the stimulant effects of the drug. This could cause or worsen Adderall side effects such as trouble sleeping, anxiety, and increased heart rate.

You should avoid consuming large amounts of caffeine with Adderall. Caffeine is found in several foods and drinks, such as:

  • tea, including green tea
  • coffee
  • chocolate
  • cola drinks

Adderall and cannabis or CBD

Cannabis (marijuana) and cannabis products, such as cannabidiol (CBD), have not been specifically reported to interact with Adderall. However, as with any drug or supplement, talk with your doctor before taking cannabis in combination with Adderall. The impact of cannabis may affect how well you stick to your Adderall treatment plan.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Certain medical conditions and other factors may increase the risk of interactions with Adderall. Before you take Adderall, be sure to talk with your doctor about your health history. Adderall may not be the right treatment option if you have certain medical conditions or other factors affecting your health. These include:

  • High blood pressure. Adderall can increase your blood pressure. If you have mildly high blood pressure, Adderall could make it worse. If you have moderately or severely high blood pressure, your doctor will likely not prescribe Adderall. To learn more, see “When to avoid Adderall” above.
  • Heart conditions. Adderall can increase your heart rate and blood pressure. If you have a heart condition, Adderall could make it worse. Your doctor may check your heart function before prescribing Adderall to make sure the drug is safe for you. If you have a serious heart condition, your doctor will likely not prescribe Adderall. To learn more, see “When to avoid Adderall” above.
  • Circulation problems. Adderall can decrease blood flow to your fingers and toes. If you have a circulation problem such as Raynaud’s disease, taking Adderall could worsen your symptoms.
  • Mental health conditions. If you have a mental health condition such as bipolar disorder, anxiety, psychosis, or schizophrenia, taking Adderall could worsen your symptoms.
  • Tourette’s syndrome or tics. If you haveTourette’s syndrome or tics affecting movements or speech, taking Adderall could worsen your symptoms.
  • Seizures. If you have a seizure disorder, taking Adderall could increase your risk of having a seizure.
  • Allergic reaction. If you’ve had an allergic reaction to Adderall or any of its ingredients, taking the drug could cause such a reaction. You could also have an allergic reaction with Adderall if you’ve had such a reaction to other drugs called amphetamines. (Adderall is a type of amphetamine.)
  • Hyperthyroidism. Taking Adderall can increase your heart rate and blood pressure. Hyperthyroidism can also cause these symptoms. If you have hyperthyroidism, Adderall could worsen your symptoms.
  • Glaucoma. Adderall can increase the pressure in your eyes. If you have glaucoma, taking Adderall could worsen your condition.
  • Agitation. If you’re in an agitated state, taking Adderall could worsen it. Agitation refers to feeling restless, nervous, or annoyed. Sometimes it can be due to a mental health condition.
  • Past drug misuse or dependence. Adderall has a risk of misuse and dependence. If you’ve misused or been dependent on drugs in the past, you may have an increased risk of these problems with Adderall. In fact, the drug has a boxed warning about this risk. This is a serious warning from the Food and Drug Administration (FDA). To learn more, see “Boxed warning: Risk of misuse and dependence” at the top of this article.
  • Pregnancy. It’s not known if Adderall is safe to take during pregnancy.
  • Breastfeeding. You should not take Adderall if you’re breastfeeding. The drug can pass into breast milk and cause side effects in a child who is breastfed.

Here are some frequently asked questions about Adderall and possible interactions.

Does Adderall interact with antihistamines?

Adderall is not known to interact with antihistamines (medications that treat allergies). However, some antihistamines can make you feel drowsy. Examples include chlorpheniramine and diphenhydramine (Benadryl). Adderall tends to make you more alert than usual. So if you take it with one of these antihistamines, Adderall may reduce drowsiness from the antihistamine.

It’s generally considered safe to take Adderall with antihistamines. If you have additional questions about taking these medications together, talk with your doctor or pharmacist.

Can you take gabapentin and Adderall together?

Adderall is not known to interact with gabapentin (Neurontin, Gralise, Horizant). Gabapentinis a seizure medication that’s also prescribed for nerve pain.

However, if you take gabapentin to help prevent seizures, it’s important to note that Adderall can increase your risk of having a seizure. This means that gabapentin may not work as well as usual to help prevent seizures if you take it with Adderall.

Your doctor and pharmacist can help answer other questions you have about Adderall and gabapentin.

Are there interactions between Adderall and Ativan or Klonopin?

There are no known interactions between Adderall and lorazepam (Ativan) or clonazepam (Klonopin). They can be used together safely if you take them as your doctor prescribes.

Ativan and Klonopin are a type of drug called benzodiazepines and are used to relieve anxiety. Adderall is sometimes prescribed with these drugs for people who have both anxiety and attention deficit hyperactivity disorder (ADHD).

Klonopin is sometimes also used to help prevent certain types of seizures. It’s important to note that Adderall can increase your risk of having a seizure. This means Klonopin may not work as well as usual to help prevent seizures if you take it with Adderall.

If you’re interested in taking Adderall with Ativan or Klonopin, talk with your doctor. They can advise you on the right treatment plan for you.

You can take certain steps to help prevent interactions with Adderall. Your doctor and pharmacist are key resources, so reach out to them before starting treatment. For example, you should plan the following:

  • Let them know if you drink alcohol or use cannabis.
  • Tell them about any other medications you take, as well as any supplements, herbs, and vitamins.
  • Create a medication list, which your doctor and pharmacist can help you fill out.
  • Check with your doctor or pharmacist before taking any new medications, supplements, herbs, or vitamins while you’re taking Adderall.

It’s also important to read the label of Adderall and other paperwork that comes with the drug. The label may have colored stickers that mention an interaction. And the paperwork, sometimes called the prescribing information, may contain details about interactions. If this information is difficult to understand, ask your doctor or pharmacist to help explain it.

You can also help prevent interactions with Adderall by taking it exactly as your doctor prescribes.

Besides learning about interactions, you may want to find out more about Adderall. These resources might help:

  • Overview of Adderall. For a general overview of Adderall, you can see this article.
  • Side effects. If you’re interested in the side effects of Adderall, see this article. Another option is to refer to the prescribing information for Adderall and Adderall XR.
  • Cost. If you’d like to learn about Adderall and cost, see this article.
  • Drug comparison. For information abouthow Adderall compares with other drugs, such as modafinil, Strattera, and methylphenidate, see this article. You can also find information about how Adderall compares with the following medications:
    • Dexedrine
    • Vyvanse
    • Ritalin
    • Concerta
    • guanfacine
  • Facts about your condition. To learn more about attention deficit hyperactivity disorder (ADHD), see our list of related articles. For more information about narcolepsy, you can visit our science of sleep hub and list of sleep articles.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

How to increase efficiency when you have attention deficit? — RISE on vc.ru

This is the second part, dedicated to the problem of ADHD and ways to improve performance. In the previous material, we talked about the fact that: 10% of the population has ADHD and only 5% are diagnosed with it, the brain has a Basic Network and a Network of Tasks that work alternately, and violations in their work lead to ADHD.

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In touch RISE : community about nootropics and personal productivity. Today we will talk about the role of dopamine in our ability to concentrate, and about the main ways that increase dopamine. We will also touch on the behavior of people with ADHD in relation to sources of dopamine.

Disclaimer : I am not a psychiatrist and do not recommend the use of medication. Also, do not self-diagnose ADHD, focusing on an article from the Internet. The doctor prescribes drugs and makes a diagnosis. Based on a podcast by Stanford University neuroscientist Andrew Huberman.

Dopamine and attention deficit

Dopamine plays a key role in focusing attention. Previously, we have already touched on the dopamine, acetylcholine, adrenaline ligament, which maintains efficiency in the process of performing tasks. But today we will figure out how dopamine works, and what are the most accessible sources of it.

How to improve efficiency, knowing the structure of the brain?

Parts of the brain mentioned above are Basic Network and Task Network . They are like musicians in a band: they are only good when they work in sync. The essence of these areas of the brain is that when one works, the second does not show activity. This is typical for normal people, without ADHD.

Dopamine is responsible for the harmony in the work of these two networks. Its sufficiently high level provides adequate excitation and relaxation in the networks, normalizing behavior. If there is little dopamine, then both of these networks are excited chaotically, thereby switching the person’s attention from object to object.

This explanation for ADHD has been called the “low dopamine hypothesis in ADHD”. Curiously, when a healthy person’s dopamine levels drop, he behaves in much the same way as a person with ADHD. Attention wanders, it is difficult to gather thoughts together, you frantically grab everything in a row, and everything literally flows out of your hands. The reason is that two areas of the brain are at work at the same time, competing for your personal activity.

How to increase efficiency, knowing about these symptoms? Oddly enough, but we do it ourselves and unconsciously. And here’s how.

Instinct for dopamine in people with ADHD

These observations were carried out in the period 1940-1960 in the USA, and were possible due to the widespread availability of tools that affect the human mind. People who were then still diagnosed with attention deficit disorder behaved as follows: they drank 8 cups of espresso a day, smoked a pack of cigarettes, and used, when available, cocaine and amphetamine, thereby raising their dopamine and norepinephrine. As for children with ADHD, they had an incredible craving for sweets, too strong even for children.

An interesting hypothesis emerges. All these substances: coffee, sugar, cigarettes, cocaine and methamphetamine increase dopamine levels. That is, either a person cannot control himself and uses those substances that cause the formation of bad habits. Or the body itself is consciously looking for sources of dopamine to cover its deficiency.

If we look at the modern drugs that are prescribed for ADHD in the Western market, the list will be: Ritalin, Modafinil, Adderall. All of them are modified forms of amphetamine. It is clear now why Walter White pursued his goals so purposefully 😉

Ways to increase dopamine

Coffee is the most affordable way to increase dopamine, as it simultaneously increases the sensitivity of dopamine receptors and stimulates the release of dopamine. Excess dopamine is metabolized into norepinephrine, allowing you to literally “rive attention” to a specific object. You can read more about the effectiveness of coffee here. In parallel with improvised tools, farming is also developing. industry. Its capabilities are wider, but also many times more dangerous.

Stimulants and their dark side

Ritalin, adderall, modafinil. Ritalin was the first drug to treat ADHD, today it is considered obsolete. Modafinil was available for some time in pharmacy chains in Russia, but then it was removed from sale. For the acquisition, storage, distribution – pay for freedom, the use of modafinil is not worth it. They say there is an analogue of the drug – hydrafinil. But, firstly, the hydrafinil formula itself acts on the body with a bunch of side effects, now it seems like no production has licenses for the production of hydrafinil, and what is sold on the Internet in packs, at best, will be ground phenotropil or chalk.

That leaves Adderall, the best drug for ADHD, because unlike modafinil, it doesn’t last long. Modafinil provides an increase in dopamine and keeps it at its peak for 4-6 hours. Therefore, the natural increase in dopamine from the body will lead to side effects. Adderall, on the other hand, works for 30-60 minutes, and is able to adequately close the “dopamine pit” that is intermittent in people with ADHD.

The problem with these drugs is that when prescribed, in the US, 25% of students and 35% of the population aged 17 to 35 use Adderall without a doctor’s prescription. It is also curious that all these drugs are stimulants. But for people with ADHD, instead of defocusing even more, on the contrary, they relax and calm them down. And that’s why.

How Stimulants Calm the Brain

Back to the Core Network and the Task Network. The task network is responsible for our composure and activity. It contains the key to how to increase efficiency in the process of solving problems. Stimulants that affect the task network literally show the brain how to behave when dopamine levels are high.

Something similar happens to a person who takes antidepressants while undergoing treatment for depression. Antidepressants, if it’s an SSRI, help build up serotonin in the synaptic clefts, thereby showing the brain that this is what you feel when there is a lot of serotonin.

Life hack. Back to stimulants and performance. When I couldn’t focus on something myself, I started to convince myself that it was the most interesting thing in the world. What I read or write about incredibly interesting gizmos, and after 5-10 minutes I sincerely believed in it and immersed myself in work.

Approximately the same thing happens when taking drugs for ADHD. The brain is helped to “get on track”, after which the person remains to maintain the position for as long as possible. But what exactly these pills do for a healthy brain, especially in the long run, is an open question.

How to improve performance using diet

In addition to drugs, there are safer tools to increase concentration. I must say right away that if you google “diet for ADHD”, then the list will be filled with a variety of, and often useless diets: gluten-free, keto, with the rejection of glucose or coffee. Therefore, before something is, or something to refuse, let’s turn to the study.

100 children divided into 2 groups of 50 people: experimental and control. Moreover, after some time the children were changed places. The results were evaluated through the presence of volitional behavior in children. And the influence of the oligo-antigenic diet was investigated.

An oligo-antigenic diet is when a person passes the maximum number of tests to detect allergies to specific types of food. After that, all these types of food are excluded from the diet. Based on the results of the study, the following conclusions were made:

  • Yes, the oligo-antigenic diet reduces the symptoms of ADHD, and sometimes it can completely eliminate the symptoms, curing ADHD.
  • However, if a child avoids foods to which he has a slight allergy from childhood, it may well be that with age the response to the allergen from the body may be many times stronger.
  • Avoiding allergens has a positive effect on well-being in the moment, but how does this affect the long term?

The most important thing on this path is the ability to listen to yourself. Get a notepad or file on your phone where you can record what you ate and how your body reacted to it. And through long and difficult trial and error, you will build a personal diet that will help you achieve efficiency and performance.

Omega 3 and ADHD

Separately, there is talk that the Omega supplement can get rid of ADHD. But, as with many brain drugs, there are a number of nuances:

  • Optimal intake starts from 1000 to 2000 milligrams per day. We are talking about the liquid form of Omega 3, but capsules are also suitable.
  • The daily dose of Omega 3 should contain 1000+ milligrams of EPA – eicosapentoenoic acid. It is found in abundance in fatty fish.
  • Under these conditions, it is possible to achieve the desired effect of ADHD drugs by using a lower dosage of these drugs.

That is, omega 3 alone will not relieve you of ADHD, but when taken with drugs, omega can enhance the effect of active ingredients. At the same time, when it comes to Omega, it is important to return to the categories of substances: modulators and mediators.

Mediators are substances that directly affect specific processes in the body. And modulators are involved in the process indirectly, like sleep, for example. It seems like he does nothing of the kind, but try not to sleep for 2 days.

Omega 3, diet, lifestyle are the same modulators. By themselves, they will not get rid of ADHD, but together with treatment they can achieve a more pronounced effect.

Insights on how to improve performance in attention deficit

The diamond bullet does not exist. If ADHD is diagnosed, then the treatment is prescribed by a psychiatrist, and you should follow his recommendations. However, using modulators such as diet, omega 3, and self-control can increase the effectiveness of certain drugs.

Classic caffeine or sugary foods can help you quickly achieve efficiency. But this is not a panacea, but a momentary injection into the body’s performance.

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Author: Philip Donchev, RISE community editor

Maternal anxiety and ADHD treatment. What Sofiko Shevardnadze talked about with Mikhail Labkovsky

At the very beginning, Sofiko makes a remark – this is her first interview in the past six months. During this time, she became a mother, and the picture of her world has changed – the happiness of motherhood goes hand in hand with feelings of responsibility for the life of a child. Such frankness sets the tone for a conversation with Mikhail Labkovsky, a psychologist and author of the book “I want and I will. Accept yourself, love life and become happy.” We are publishing the abstracts of the interview, which can be viewed in full on the YouTube channel “Just about the difficult with Sofiko Shevardnadze.”

Being a mother and doing what you want is possible . Contrary to the popular belief that the birth of a child changes the priorities in the life of parents and now children’s happiness is at the forefront, Mikhail convinces that in fact there should not be such drastic changes.

Psychologically, the older the parent, the better the child . It is mature mothers and fathers who statistically spend more time with their children than younger ones. But to resolve the dispute around the benefits and threats to health in late childbirth, you should turn to genetics.

Women who are not happy with motherhood should get tested for postpartum depression . Otherwise, there will be no happiness for either the mother or the child.

Attention deficit hyperactivity disorder took away years of quiet life from Mikhail , only taking special medications proved to be effective. These are drugs based on Adderall, and they are not sold in Russia.

“A healthy person does not have a mild form of anything!” If you suddenly wake up and feel that the joy in life has become an order of magnitude less and your mood has nothing to do with it, you should talk to a specialist.

Life with parents is taboo for an adult . Mikhail is sure that in such conditions it is difficult for an age “child” to build personal boundaries.

The one-no rule always works! Labkovsky recommends: if, while solving a serious problem with your partner, parent, or even just an acquaintance, your “no” is not heard the first time, there is no point in trying to say it twice. There are two options here – either continue to endure an uncomfortable position, or leave. Even when it comes to your own mother. Cruel, but true, according to Michael.

“Choosing a psychologist is a minefield.” Mikhail advises how to get through it so as not to stumble upon a bomb. Here are his requirements for a specialist:

  • Traditional psychological education is a diploma.
  • Work experience – at least five years.
  • During the sessions, the client should feel comfortable with the psychologist. No shock therapy! Only comfortable communication.
  • Positive dynamics at least three to four weeks after the first dose. If you feel that you are not moving forward with your problem, it is worth changing a specialist.

The best psychological technique is the one that works. There are many areas of practical and theoretical psychology in the world. Mikhail suggests leaving the decision on the effectiveness of each approach to the client.

“80% of good media content is now on YouTube. Viewers there are the most active, and interaction with them is productive and interesting. We are in for a big season: actual heroes with empathy and new ideas, success algorithms. Spin-offs will definitely appear, plans “make a travel blog around Russia. But our project will remain a laboratory-conversation with a person. And our idea of ​​just talking about complex things will remain unchanged,” program producer Alexei Bokov comments on the release.

Issues of “Just about the difficult things with Sofiko Shevardnadze” have been published on Yandex.Ether since October 2019. The goal of the project is to discuss and explain to the viewer the complex phenomena that occur in everyday life in the format of a conversation with an expert.