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Milk of magnesia pill: Phillips Milk of Magnesia 311 mg chewable tablet

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Milk of Magnesia Uses, Side Effects & Warnings

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Generic name: magnesium hydroxide [ mag-NEE-see-um-hye-DROCK-side ]
Brand names: Ex-Lax Milk of Magnesia, Milk of Magnesia, Pedia-Lax Chewable, Phillips Milk of Magnesia
Drug classes: Antacids, Laxatives

Medically reviewed by Drugs.com on Nov 11, 2022. Written by Cerner Multum.

What is Milk of Magnesia?

Magnesium is a naturally occurring mineral. Milk of Magnesia reduces stomach acid, and increases water in the intestines which may induce bowel movements.

Milk of Magnesia is used as a laxative to relieve occasional constipation.

Milk of Magnesia is also used as an antacid to relieve indigestion, sour stomach, and heartburn.

Milk of Magnesia may also be used for purposes not listed in this medication guide.

Warnings

Do not use Milk of Magnesia without a doctor’s advice if you have stomach pain, nausea, or vomiting.

Before taking this medicine

Do not use Milk of Magnesia without a doctor’s advice if you have stomach pain, nausea, or vomiting.

Ask a doctor or pharmacist if Milk of Magnesia is safe to use if:

  • you have kidney disease;

  • you are on a low-magnesium diet; or

  • you have a sudden change in bowel habits that has been ongoing for longer than 2 weeks.

Ask a doctor before using this medicine if you are pregnant or breastfeeding.

How should I take Milk of Magnesia?

Use exactly as directed on the label, or as prescribed by your doctor.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

You may need to shake the oral suspension before each use.

You must chew the chewable tablet before you swallow it.

Take this medicine with a full glass (8 ounces) of water.

When taken as a laxative, Milk of Magnesia should produce a bowel movement within 30 minutes to 6 hours.

Call your doctor if the condition you are treating with Milk of Magnesia does not improve, or if it gets worse while using this medicine.

Do not use Milk of Magnesia for longer than 7 days without medical advice.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Since Milk of Magnesia is used when needed, you may not be on a dosing schedule. Skip any missed dose if it’s almost time for your next dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe diarrhea, muscle weakness, shortness of breath, and little or no urination.

What should I avoid while taking Milk of Magnesia?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Milk of Magnesia side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Milk of Magnesia may cause serious side effects. Stop using Milk of Magnesia and call your doctor at once if you have:

  • severe nausea, vomiting, or diarrhea;

  • no bowel movement after using the medicine as a laxative;

  • rectal bleeding; or

  • worsening symptoms.

Common side effects of Milk of Magnesia may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Milk of Magnesia?

Other drugs may affect Milk of Magnesia, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Frequently asked questions

  • How often can you give a 4-year-old Milk of Magnesia?

More about Milk of Magnesia (magnesium hydroxide)

  • Check interactions
  • Compare alternatives
  • Pricing & coupons
  • Reviews (45)
  • Latest FDA alerts (5)
  • Side effects
  • Dosage information
  • During pregnancy
  • Support group
  • Drug class: antacids
  • Breastfeeding
  • En español

Patient resources

Other brands

Phillips’ Milk of Magnesia, Dulcolax Milk of Magnesia, Ex-Lax Milk of Magnesia, Pedia-Lax Chewable Tablets

Related treatment guides

  • Constipation
  • Acne
  • Indigestion

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 5.01.

Milk of Magnesia (magnesium hydroxide) dosing, indications, interactions, adverse effects, and more

Dosing & Uses

AdultPediatric

Dosage Forms & Strengths

chewable tablet
  • 311mg
  • 400mg
suspension
  • 7.75%
  • 400mg/5mL
  • 800mg/5mL
  • 1200mg/15mL
  • 2400mg/10mL

Constipation

Magnesium hydroxide (400 mg/5 mL): 30-60 mL/day PO at bedtime or in divided doses

Magnesium hydroxide (800 mg/5 mL): 15-30 mL/day PO at bedtime or in divided doses

Chewable tablet: 8 tablets/day PO at bedtime or in divided doses

Acid Indigestion

Magnesium hydroxide (400 mg/5 mL): 5-15 mL PO q4hr; no more than 4 doses per 24-hour period

Chewable tablet: 2-4 tablets PO q4hr; no more than 4 doses per 24-hour period

Dosage Forms & Strengths

chewable tablet
  • 311mg
  • 400mg
suspension
  • 7. 75%
  • 400mg/5mL
  • 800mg/5mL
  • 1200mg/15mL
  • 2400mg/10mL

Constipation

Suspension
  • 2-6 years: 5-15 mL/day of regular-strength liquid PO at bedtime or in divided doses
  • 6-12 years: 15-30 mL/day (400 mg/5 mL) or 7.5-15 mL/day (800 mg/5 mL) PO at bedtime or in divided doses
  • ≥12 years: 30-60 mL/day (400 mg/5 mL) or 15-30 mL/day (800 mg/5 mL) PO at bedtime or in divided doses
Chewable tablet
  • 3-6 years: 2 tablets PO once daily or in divided doses
  • 6-12 years: 4 tablets PO once daily or in divided doses
  • >12 years: 8 tablets PO once daily or in divided doses

Acid Indigestion

Liquid
  • ≥12 years: 5-15 mL (400 mg/5 mL) PO q4hr; no more than 4 doses per 24-hour period
Chewable tablet
  • ≥12 years: 2-4 tablets PO q4hr; no more than 4 doses per 24-hour period

Interactions

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          Serious – Use Alternative (13)
          • baloxavir marboxil

            magnesium hydroxide will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. Avoid or Use Alternate Drug. Baloxavir may bind to polyvalent cations resulting in decreased absorption. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Human studies not conducted.

          • demeclocycline

            magnesium hydroxide decreases levels of demeclocycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.

          • doxycycline

            magnesium hydroxide decreases levels of doxycycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.

          • eltrombopag

            magnesium hydroxide decreases levels of eltrombopag by inhibition of GI absorption. Applies only to oral form of both agents. Contraindicated. Separate by at least 4 hours.

          • infigratinib

            magnesium hydroxide will decrease the level or effect of infigratinib by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. If use with an acid-reducing agent cannot be avoided, administer infigratinib 2 hr before and after administration of a locally-acting antacid.

          • minocycline

            magnesium hydroxide decreases levels of minocycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.

          • oxytetracycline

            magnesium hydroxide decreases levels of oxytetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.

          • pazopanib

            magnesium hydroxide will decrease the level or effect of pazopanib by increasing gastric pH. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Avoid coadministration of pazopanib with drugs that raise gastric pH; may use short-acting antacids in place of PPIs and h3 antagonists, but separate antacid and pazopanib dosing by several hours

          • ponatinib

            magnesium hydroxide decreases levels of ponatinib by increasing gastric pH. Applies only to oral form of both agents. Avoid or Use Alternate Drug.

          • potassium phosphates, IV

            magnesium hydroxide decreases effects of potassium phosphates, IV by cation binding in GI tract. Avoid or Use Alternate Drug. Magnesium decreases serum phosphate concentration by binding dietary phosphate. Use alternatives if available.

          • raltegravir

            magnesium hydroxide will decrease the level or effect of raltegravir by cation binding in GI tract. Avoid or Use Alternate Drug. Magnesium containing antacids reduce raltegravir plasma levels when taken within 6 hr of raltegravir dose

          • sotorasib

            magnesium hydroxide will decrease the level or effect of sotorasib by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug. If use with an acid-reducing agent cannot be avoided, administer sotorasib 4 hr before or 10 hr after administration of a locally-acting antacid.

          • tetracycline

            magnesium hydroxide decreases levels of tetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Avoid or Use Alternate Drug.

          Monitor Closely (23)
          • bictegravir

            magnesium hydroxide will decrease the level or effect of bictegravir by cation binding in GI tract. Modify Therapy/Monitor Closely. Bictegravir can be taken under fasting conditions 2 hr before antacids containing Al, Mg, or Ca. Routine administration of bictegravir simultaneously with, or 2 hr after, antacids containing Al, Mg, or Ca is not recommended.

          • cabotegravir

            magnesium hydroxide will decrease the level or effect of cabotegravir by cation binding in GI tract. Modify Therapy/Monitor Closely. Administer antacid products at least 2 hr before or 4 hr after taking oral cabotegravir.

          • chloroquine

            magnesium hydroxide will decrease the level or effect of chloroquine by Mechanism: inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Separate doses by at least 4 hr

          • ciprofloxacin

            magnesium hydroxide decreases levels of ciprofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Coadministration of ciprofloxacin with multivalent cation-containing products may reduce the bioavailability of ciprofloxacin by 90%. Administer ciprofloxacin at least 2 hours before or 6 hours after using these products. Use alternatives if available.

          • crizotinib

            magnesium hydroxide decreases levels of crizotinib by increasing gastric pH. Applies only to oral form of both agents. Use Caution/Monitor. Drugs that elevate the gastric pH may decrease the solubility of crizotinib and subsequently reduce its bioavailability. However, no formal studies have been conducted. .

          • deferiprone

            magnesium hydroxide decreases levels of deferiprone by enhancing GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations.

          • deflazacort

            magnesium hydroxide and deflazacort both decrease serum potassium. Use Caution/Monitor.

          • dolutegravir

            magnesium hydroxide will decrease the level or effect of dolutegravir by cation binding in GI tract. Use Caution/Monitor. Administer dolutegravir 2 hr before or 6 hr after taking medications containing polyvalent cations; use alternative therapy if available

          • fleroxacin

            magnesium hydroxide decreases levels of fleroxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

          • gemifloxacin

            magnesium hydroxide decreases levels of gemifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

          • lanthanum carbonate

            lanthanum carbonate, magnesium hydroxide. cation binding in GI tract. Use Caution/Monitor. Administer antacid at least 2 hours before or after lanthanum. .

          • levofloxacin

            magnesium hydroxide decreases levels of levofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

          • moxifloxacin

            magnesium hydroxide decreases levels of moxifloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

          • ofloxacin

            magnesium hydroxide decreases levels of ofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

          • omadacycline

            magnesium hydroxide will decrease the level or effect of omadacycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

          • pancrelipase

            magnesium hydroxide decreases effects of pancrelipase by pharmacodynamic antagonism. Use Caution/Monitor. Antacids may negate beneficial effects of enzymes.

          • penicillamine

            magnesium hydroxide decreases levels of penicillamine by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

          • pexidartinib

            magnesium hydroxide will decrease the level or effect of pexidartinib by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Separate pexidartinib by 2 hr before or after taking a locally-acting antacid.

          • riociguat

            magnesium hydroxide decreases levels of riociguat by inhibition of GI absorption. Applies only to oral form of both agents. Use Caution/Monitor. Separate administration by at least 1 hour.

          • sarecycline

            magnesium hydroxide will decrease the level or effect of sarecycline by inhibition of GI absorption. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. Multivalent cation-containing products may impair absorption of tetracyclines, which may decrease its efficacy. Separate dosing of tetracyclines from these products.

          • sodium phosphates, IV

            magnesium hydroxide decreases effects of sodium phosphates, IV by cation binding in GI tract. Modify Therapy/Monitor Closely. Magnesium decreases serum phosphate concentration by binding dietary phosphate. Use alternatives if available.

          • vismodegib

            magnesium hydroxide will decrease the level or effect of vismodegib by Other (see comment). Use Caution/Monitor. Drugs that increase gastric pH alter vismodegib solubility and therefore reduce bioavailability; effect on efficacy unknown

          • vitamin D

            vitamin D increases levels of magnesium hydroxide by Other (see comment). Use Caution/Monitor.
            Comment: Vitamin D can increase serum magnesium concentrations, particularly in the presence of renal impairment. The combined use of vitamin D and magnesium-containing products should be avoided, if possible, in patients with chronic renal failure.

          Minor (41)
          • amikacin

            amikacin decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • amiloride

            amiloride increases levels of magnesium hydroxide by decreasing renal clearance. Minor/Significance Unknown.

          • amphotericin B deoxycholate

            amphotericin B deoxycholate decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • bazedoxifene/conjugated estrogens

            bazedoxifene/conjugated estrogens decreases levels of magnesium hydroxide by Other (see comment). Minor/Significance Unknown.
            Comment: Magnesium shifted from blood to tissue storage.

          • bendroflumethiazide

            bendroflumethiazide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • bumetanide

            bumetanide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • calcitonin salmon

            calcitonin salmon increases levels of magnesium hydroxide by decreasing renal clearance. Minor/Significance Unknown.

          • chlorothiazide

            chlorothiazide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • chlorthalidone

            chlorthalidone decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • conjugated estrogens

            conjugated estrogens decreases levels of magnesium hydroxide by Other (see comment). Minor/Significance Unknown.
            Comment: Magnesium shifted from blood to tissue storage.

          • conjugated estrogens, vaginal

            conjugated estrogens, vaginal decreases levels of magnesium hydroxide by Other (see comment). Minor/Significance Unknown.
            Comment: Magnesium shifted from blood to tissue storage.

          • cyclopenthiazide

            cyclopenthiazide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • dextrose

            dextrose decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • dextrose (Antidote)

            dextrose (Antidote) decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • digoxin

            digoxin decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • doxercalciferol

            doxercalciferol increases levels of magnesium hydroxide by enhancing GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

          • drospirenone

            drospirenone increases levels of magnesium hydroxide by decreasing renal clearance. Minor/Significance Unknown.

          • estradiol

            estradiol decreases levels of magnesium hydroxide by Other (see comment). Minor/Significance Unknown.
            Comment: Magnesium shifted from blood to tissue storage.

          • estrogens conjugated synthetic

            estrogens conjugated synthetic decreases levels of magnesium hydroxide by Other (see comment). Minor/Significance Unknown.
            Comment: Magnesium shifted from blood to tissue storage.

          • estrogens esterified

            estrogens esterified decreases levels of magnesium hydroxide by Other (see comment). Minor/Significance Unknown.
            Comment: Magnesium shifted from blood to tissue storage.

          • estropipate

            estropipate decreases levels of magnesium hydroxide by Other (see comment). Minor/Significance Unknown.
            Comment: Magnesium shifted from blood to tissue storage.

          • ethacrynic acid

            ethacrynic acid decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • furosemide

            furosemide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • gentamicin

            gentamicin decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • glucagon intranasal

            glucagon intranasal increases levels of magnesium hydroxide by decreasing renal clearance. Minor/Significance Unknown.

          • hydrochlorothiazide

            hydrochlorothiazide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • ibandronate

            magnesium hydroxide decreases levels of ibandronate by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

          • indapamide

            indapamide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • mannitol

            mannitol decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • mestranol

            mestranol decreases levels of magnesium hydroxide by Other (see comment). Minor/Significance Unknown.
            Comment: Magnesium shifted from blood to tissue storage.

          • methyclothiazide

            methyclothiazide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • metolazone

            metolazone decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • neomycin PO

            neomycin PO decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • nitrofurantoin

            magnesium hydroxide decreases levels of nitrofurantoin by inhibition of GI absorption. Applies only to oral form of both agents. Minor/Significance Unknown.

          • paromomycin

            paromomycin decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • sodium polystyrene sulfonate

            sodium polystyrene sulfonate increases levels of magnesium hydroxide by decreasing renal clearance. Minor/Significance Unknown. Risk of alkalosis.

          • spironolactone

            spironolactone increases levels of magnesium hydroxide by decreasing renal clearance. Minor/Significance Unknown.

          • streptomycin

            streptomycin decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • tobramycin

            tobramycin decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • torsemide

            torsemide decreases levels of magnesium hydroxide by increasing renal clearance. Minor/Significance Unknown.

          • triamterene

            triamterene increases levels of magnesium hydroxide by decreasing renal clearance. Minor/Significance Unknown.

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          Adverse Effects

          Frequency Not Defined

          Abdominal cramping

          Diarrhea

          Electrolyte imbalance

          Hypotension

          Muscle weakness

          Respiratory depression

          Previous

          Next:

          Warnings

          Contraindications

          Renal failure

          Existing electrolyte imbalance

          Appendicitis symptoms or acute surgical abdomen

          Myocardial damage or heart block

          Fecal impaction or rectal fissures

          Intestinal obstruction or perforation

          Undiagnosed abdominal pain

          Cautions

          Use with caution in renal insufficiency

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          Pregnancy & Lactation

          Pregnancy category: A

          Lactation: Use in nursing mothers appears to be safe

          Pregnancy Categories

          A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

          B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done. D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk. X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist. NA: Information not available.

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          Pharmacology

          Mechanism of Action

          Laxative: Promotes osmotic retention of fluid, which distends the colon with increased peristaltic activity and stimulates bowel evacuation

          Antacid: Reacts with hydrochloric acid in stomach to form magnesium chloride

          Absorption

          Bioavailability: 15-30%

          Onset: 0. 5-6 hr (laxative)

          Elimination

          Excretion: Urine (up to 30% as absorbed magnesium), feces (as unabsorbed drug)

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          Images

          Phillips Milk of Magnesia oral

          400 mg/5 mL suspension
          Phillips Milk of Magnesia oral

          400 mg/5 mL suspension
          Phillips Milk of Magnesia oral

          400 mg/5 mL suspension
          Phillips Milk of Magnesia oral

          400 mg/5 mL suspension
          Phillips Milk of Magnesia oral

          311 mg chewable tablet
          Phillips Milk of Magnesia oral

          400 mg/5 mL suspension
          Phillips Milk of Magnesia oral

          400 mg/5 mL suspension
          Phillips Milk of Magnesia oral

          400 mg/5 mL suspension
          Phillips Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Milk of Magnesia oral

          400 mg/5 mL suspension
          Dulcolax (magnesium hydroxide) oral

          400 mg/5 mL suspension
          Dulcolax (magnesium hydroxide) oral

          1,200 mg chewable tablet
          Pedia-Lax (mag hydroxide) oral

          400 mg (170 mg magnesium) chewable tablet

          Copyright © 2010 First DataBank, Inc.

          Milk of Magnesia – instructions for use, doses, side effects, reviews of the drug:

          0.001‰

          All forms of release, dosages, registration certificates, drug manufacturers, drug characteristics

          Description of the drug Milk of Magnesia (oral suspension, 415 mg/5 ml) based on the official instructions, approved by the manufacturer in 1998

          Date of approval: 31.07.1998

          Contents

          • Active substance
          • Pharmacological group
          • Nosological classification (ICD-10)
          • Composition and form of release
          • pharmachologic effect
          • pharmachologic effect
          • Indications
          • Contraindications
          • Dosage and administration
          • Side effects
          • Storage conditions
          • Best before date
          • Reviews

          Active ingredient

          Magnesium hydroxide

          Pharmacological group

          Antacids

          Laxatives

          Nosological classification (ICD-10)

          ICD-10 code list

          • K21 Gastroesophageal reflux
          • K25 Gastric ulcer
          • K26 Duodenal ulcer
          • K29 Gastritis and duodenitis
          • K30 Dyspepsia
          • K31 Other diseases of the stomach and duodenum
          • K59. 0 Constipation
          • R14 Flatulence and related conditions

          Composition and formulation

          1 tablet contains magnesium hydroxide 300 mg; per pack 24 pcs.

          5 ml suspension for oral administration – 415 mg; in vials of 300 ml.

          Pharmacological action

          Pharmacological action

          antacid , laxative .

          Neutralizes free hydrochloric acid in the stomach, lowers the peptic activity of gastric juice, accelerates the motility of the stomach and intestines (without secondary hypersecretion of hydrochloric acid and metabolic alkalosis).

          Neutralizes free hydrochloric acid in the stomach, reduces the peptic activity of gastric juice, accelerates the motility of the stomach and intestines (without secondary hypersecretion of hydrochloric acid and metabolic alkalosis).

          Indications

          Increased acidity of gastric juice, gastralgia, dyspepsia, heartburn, acute duodenitis, peptic ulcer of the stomach and duodenum, flatulence, constipation.

          Contraindications

          Age (for suspension – up to 3 years; for tablets – up to 6 years).

          Dosage and administration

          Information for healthcare professionals only.
          Are you a healthcare professional?

          By mouth (may be taken with milk or water).

          With heartburn and other dyspeptic symptoms, 2–4 tab. or 1-2 teaspoons of suspension; children from 3 to 12 years old – 1 teaspoon of suspension, children over 6 years old can also be prescribed tablets (table 1-2).

          For constipation: at bedtime 2-3 tablespoons (children under 12 years old – 1-2 teaspoons) suspension. Tablets should be chewed before swallowing, the vial with the suspension should be shaken before use.

          Side effects

          Not identified.

          Storage conditions

          In a dry place (do not freeze).

          Keep out of reach of children.

          Expiry date

          2 years.
          After opening – 6 months.
          Do not use after the expiry date which is stated on the pack.

          Reviews



          Read all reviews and leave your own.

          Information for healthcare professionals only.
          Are you a healthcare professional?

          Magnesium sulfate instructions for use: indications, contraindications, side effects – description Magnesium sulfate powder for preparation. r-ra for oral administration 20 g: Pak. 1, 2, 3, 4, 6, 8, 10, 12 or 20 pcs. (43347)

          💊 Composition of the drug Magnesium sulfate

          ✅ Application of the drug Magnesium sulfate

          Save

          Search for analogues

          Interaction

          Description of the active ingredients of the preparation

          Magnesium sulfate
          (Magnesium sulfate)

          The scientific information provided is general and cannot be used to make decisions.
          decisions about the use of a particular drug.

          Update date: 2022.03.28

          Marketing authorization holder:

          IVANOVSK PHARMACEUTICAL FACTORY, OJSC
          (Russia)

          ATX code:

          A06AD04

          (Magnesium sulfate)

          Active substance:
          magnesium sulfate
          (magnesium sulfate)

          Ph.Eur.

          European Pharmacopoeia

          Dosage form

          Magnesium sulfate

          Powder for preparation. r-ra for oral administration 20 g: Pak. 1, 2, 3, 4, 6, 8, 10, 12 or 20 pcs.

          reg. No.: LP-002672
          from 23.10.14
          – Indefinitely

          Release form, packaging and composition
          Magnesium sulfate preparation

          Powder for oral solution in the form of colorless prismatic crystals, weathered in air.

          20 g – Heat sealable bags (1) – packs of cardboard.
          20 g – Heat sealable bags (2) – packs of cardboard.
          20 g – Heat sealable bags (3) – packs of cardboard.
          20 g – Heat sealable bags (4) – packs of cardboard.
          20 g – Heat sealable bags (6) – packs of cardboard.
          20 g – Heat sealable bags (8) – packs of cardboard.
          20 g – Heat sealable bags (10) – packs of cardboard.
          20 g – Heat sealable bags (12) – packs of cardboard.
          20 g – Heat sealable bags (20) – packs of cardboard.

          Clinical and pharmacological group:

          Magnesium preparation

          Pharmacotherapeutic group:

          Laxative

          Pharmacological action

          When taken orally, it has a choleretic effect (a reflex effect on the duodenal mucosal receptors) and a laxative effect (due to poor absorption of magnesium sulfate in the intestine, a high osmotic pressure is created in it, water accumulates in the intestine, the contents bowel liquefies, peristalsis increases). It is an antidote for poisoning with salts of heavy metals. The onset of the effect is after 0.5-3 hours, the duration is 4-6 hours.

          The mechanism of anticonvulsant action is associated with a decrease in the release of acetylcholine from neuromuscular synapses, while magnesium suppresses neuromuscular transmission, has a direct inhibitory effect on the central nervous system.

          The antiarrhythmic effect of magnesium is due to a decrease in the excitability of cardiomyocytes, restoration of ionic balance, stabilization of cell membranes, disruption of sodium current, slow incoming calcium current and unilateral potassium current. The cardioprotective effect is due to the expansion of the coronary arteries, a decrease in peripheral vascular resistance and platelet aggregation.

          Tocolytic effect develops as a result of inhibition of myometrial contractility (decrease in absorption, binding and distribution of calcium in smooth muscle cells) under the influence of magnesium ion, increased blood flow in the uterus as a result of expansion of its vessels. Magnesium is an antidote for poisoning with salts of heavy metals.

          Pharmacokinetics

          After oral administration, no more than 20% of the dose is absorbed.

          C ss , at which an anticonvulsant effect develops, is – 2-3.5 mmol / l.

          Penetrates through the BBB and the placental barrier, excreted in breast milk at a concentration 2 times higher than plasma concentrations. Excreted by the kidneys, the rate of renal excretion is proportional to plasma concentration and glomerular filtration rate.

          Indications of the active substances of the drug

          Magnesium sulfate

          For oral administration: constipation, cholangitis, cholecystitis, gallbladder dyskinesia of the hypotonic type (for tubing), duodenal sounding (to obtain a gallbladder portion of bile), bowel cleansing before diagnostic manipulations.

          Poisoning with salts of heavy metals (mercury, arsenic, tetraethyl lead, barium).

          Open list of ICD-10 codes

          K59.0 Constipation
          K81.0 Acute cholecystitis
          K81.1 Chronic cholecystitis
          K82.8 Other specified diseases of the gallbladder and cystic duct (incl. dyskinesia)
          K83.0 Cholangitis
          T50.9 Other and unspecified drugs, medicaments and biological substances
          T56.0 Lead and its compounds
          T56. 1 Mercury and its compounds
          T57.0 Arsenic and its compounds
          Z51.4 Preparatory procedures for subsequent treatment or examination, not elsewhere classified

          Dosing schedule

          The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.

          For oral use. The dose, method and regimen of application, duration of therapy is determined individually, depending on the indications, the clinical situation and the age of the patient.

          Side effects

          Early signs and symptoms of hypermagnesemia: bradycardia, diplopia, sudden flushing of the face, headache, dizziness, decreased blood pressure, nausea, shortness of breath, slurred speech, vomiting, asthenia.

          Signs of hypermagnesemia (in order of increasing magnesium concentration in the blood serum): decreased deep tendon reflexes (2-3.5 mmol/l), prolongation of the PQ interval and expansion of the QRS complex on the ECG (2.5-5 mmol/l), loss of deep tendon reflexes (4-5 mmol/l), depression of the respiratory center (5-6.5 mmol/l), impaired conduction of the heart (7.5 mmol/l), cardiac arrest (12.5 mmol/l).

          Ingestion: nausea, vomiting, diarrhea, exacerbation of inflammatory diseases of the gastrointestinal tract, electrolyte imbalance (fatigue, asthenia, confusion, arrhythmia, convulsions), flatulence, spastic abdominal pain, thirst, signs of hypermagnesemia in the presence of renal insufficiency.

          Contraindications for use

          Hypersensitivity to magnesium sulfate; severe chronic renal failure, appendicitis, rectal bleeding (including undiagnosed), intestinal obstruction, dehydration, hypermagnesemia; pregnancy, breastfeeding period; children’s age up to 18 years.

          Precautions

          Impaired cardiac conduction, heart failure, chronic renal failure.

          Use in pregnancy and lactation

          Oral magnesium sulfate is contraindicated during pregnancy. If necessary, use during lactation, breastfeeding should be discontinued.

          Use in impaired renal function

          Contraindicated in severe chronic renal failure. Take with caution orally or parenterally in chronic renal failure.

          Use in children

          May be used in children according to indications, in doses and dosage forms recommended according to age. It is necessary to strictly follow the instructions in the instructions for magnesium sulfate preparations on contraindications for use in children of different ages of specific dosage forms of magnesium sulfate.

          Use in elderly patients

          Magnesium sulfate should be used with caution in elderly patients. they have reduced kidney function.

          Precautions

          Use with caution in case of heart block, myocardial damage, chronic renal failure, respiratory diseases, acute inflammatory diseases of the gastrointestinal tract.

          Magnesium sulfate should be used with caution in elderly patients In this category of balls, a reduced dose should usually be used, because. they have reduced kidney function.

          Magnesium sulfate can be used to relieve status epilepticus (as part of complex treatment).

          Causes CNS depression in case of overdose. As an antidote for an overdose of magnesium sulfate, calcium preparations are used – calcium chloride or calcium gluconate.

          The use of magnesium sulfate may distort the results of radiological studies for which technetium is used.

          Influence on the ability to drive vehicles and mechanisms

          During the period of treatment, patients should refrain from driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions (risk of developing diplopia, dizziness, headache ).

          Drug interactions

          Magnesium sulfate enhances the effect of other drugs that depress the central nervous system.

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