Safety & Side Effects: Combining Medications with Advil

• Can I take Advil for a cold or the flu?

  Yes, Advil offers a variety of treatment options depending on your cold and flu symptoms.

  Advil Tablets, Gel Caplets, Liqui-Gels and Liqui-Gels minis contain an active ingredient, called ibuprofen, which temporarily reduces fever, as well as relieves minor aches and pains due to the common cold.

  If you have additional symptoms, you can also consider using Advil Cold & Sinus and Advil Sinus Congestion & Pain products for additional relief. These products contain ibuprofen plus a nasal decongestant to provide relief for symptoms including: headache, fever, minor body aches and pains, sinus pressure, and nasal congestion.

  For further questions concerning your use of Advil products, please speak with a healthcare provider. If your symptoms continue to persist or get worse, please contact a physician immediately.

• How quickly does Advil work? How long does it last?

  It depends on which form of Advil you take as well as how your body responds to the medicine. Some Advil products are designed to deliver faster relief, so read the product label to see how often you can take a dose.

• Does Advil help you sleep?

  For sleeplessness associated with pain, check out Advil PM.

• Is Advil Safe?

  For more than 35+ years, extensive consumer use and numerous clinical studies have shown that, ibuprofen, the active ingredient in Advil, when used as directed, is a safe and effective OTC pain reliever and fever reducer. Do not to take more than 6 Advil tablets, caplets, etc. (1,200 mg) in 24 hours.

  Please refer to the full product labeling for additional safety information related to Advil.

• What are health agencies saying about the safety of ibuprofen/Advil?

  Haleon continues to monitor the rapidly evolving COVID-19 situation alongside public health authorities, including Centers for Disease Control and Prevention (CDC), World Health Organization (WHO), U. S. Food and Drug Administration (FDA) and European Medicines Agency (EMA), and medical experts. None of these agencies currently recommend that individuals should stop taking ibuprofen/Advil.

• What should I do if the peel-back label on my Advil Tablets, Advil Liqui Gels and Advil Liqui Gels Minis is torn, smudged or otherwise unreadable?

  In January 2023,  we issued a public notification to alert consumers of a defect of certain peel-back labels that may render some critical safety information unreadable.  Click here to view the full notice and how to obtain assistance.

Common NSAIDs for Back and Neck Pain

Non-steroidal anti-inflammatory drugs (NSAIDs) are a popular class of medication that can help relieve back and neck pain. There are about 20 types of NSAIDs sold in the United States, but four dominate the market:

• Aspirin
• Ibuprofen
• Naproxen
• Celecoxib

See Medications for Back Pain and Neck Pain

The strength of these medications varies. Typically, the prescription version is 2 to 4 times stronger than those sold over the counter. Prescribing doctors often give specific instructions on the medication dosage and schedule based on an individual’s situation; it is important to follow these directions carefully and not exceed the listed dose.

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Aspirin

Aspirin is available in several different strengths, ranging for 75 to 325 milligrams per tablet. People typically take aspirin in one of two ways.

• Regular strength aspirin for pain. A typical regular strength aspirin has 325 milligrams per tablet. An adult may take aspirin every 2 to 4 hours for back, neck, or joint pain. People should not take more than 12 tablets (3,900 mg) in 24 hours.
• Low-dose aspirin every day for heart attack prevention. While NSAIDs generally carry a higher risk for heart problems, aspirin is an exception. A typical low dose aspirin can reduce the clumping action of platelets in the bloodstream, which may help in preventing blood clots that cause a heart attack. For this reason, doctors often recommend that patients at risk for cardiovascular problems take a single low-dose aspirin each day.

People taking daily aspirin should be aware that using other NSAIDs at the same time can block aspirin’s crucial anti-clotting ability and increase the risk of stomach bleeding. When aspirin is taken daily for the heart, it should be taken first thing in the morning, and no other NSAIDs should be taken for at least 1 or 2 hours afterward.

Aspirin should not be given to children under age 12 or to adolescents with chicken pox or flu symptoms because of the possibility of Reye syndrome. Ringing in the ears can occur in patients taking high doses.

In This Article:

• NSAIDs: Non-Steroidal Anti-Inflammatory Drugs

• Common NSAIDs for Back and Neck Pain

• Potential Risks and Complications of NSAIDs

• Types of NSAIDs

• Anti-Inflammatory Medications for Back Pain Relief Video

Ibuprofen

Ibuprofen (Advil, Motrin) is most commonly recommended to relieve mild or moderate back pain and inflammation. In some cases, such as for people with certain types of arthritis, a doctor may suggest prescription ibuprofen for long-term use.

• Over-the-counter ibuprofen ranges from 200 to 400 milligrams per tablet. The recommended dose for an adult with mild to moderate pain is up to 600 milligrams every 4 hours.
• Prescription doses can be as high as 800 milligrams. A health care professional will often have dosage and timing recommendations based on a person’s medical history and condition.

The maximum dose for a 24-hour period is 3,200 mg—equal to four maximum adult doses. Ibuprofen can be dosed for children as young as 6 months old.

Naproxen

Naproxen (Aleve, Anaprox DS, Naprosyn) is often prescribed for people who have joint pain, swelling, and certain forms of arthritis, such as ankylosing spondylitis. It is also used to treat menstrual pain and other symptoms.

An analysis of multiple studies indicated that naproxen was associated with a lower risk of cardiovascular problems than other NSAIDs; however, the FDA has not found the evidence to be strong enough to note this difference on NSAID labels.

¹
FDA Drug Safety Communication: FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes. July 9, 201

Naproxen comes in two forms:

• Naproxen sodium is sold over-the-the counter (Aleve) and with a prescription (Anaprox, Anaprox DS, Naprelan).
• Naproxen base is slightly stronger than naproxen sodium on a milligram-per-milligram basis. It is only available with a prescription (EC-Naprosyn, Naprosyn).

The regular adult dose is one or two 220 mg pills taken within an hour. If pain relief is still needed after 8 to 12 hours, another pill may be taken. A maximum of three pills may be taken in 24 hours. Higher prescription dosages are available and may be prescribed by a doctor, depending on the patient’s situation. Older adults should use naproxen cautiously and take the lowest possible dose.

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Celecoxib

Celecoxib (Celebrex), is a type of NSAID called a COX-2 inhibitor. Unlike other NSAIDs, COX-2 inhibitors do not impair blood clotting, so they are considered safer for people taking blood-thinning medications, such as warfarin (Coumadin).

See About Celebrex (Celecoxib), a COX-2 Inhibitor

Available in 100 mg and 200 mg tablets, celecoxib is dosed once or twice daily with a maximum daily dose of 800 mg. Celecoxib is used for juvenile rheumatoid arthritis in children as young as 2 years old. Celecoxib is not recommended for those with sulfonamide, aspirin, or NSAID allergies or in those with certain cardiovascular or gastrointestinal risk factors.

See Potential Risks and Complications of Celecoxib

Individuals differ widely in how their bodies respond to medication. If the first medication tried doesn’t seem to have the desired effect, it may be necessary to try other kinds to get relief.

Dr. Kathee de Falla is a licensed and certified pharmacist. She has more than a decade of experience providing medical advice and supplying prescription medications in a retail setting. Dr. de Falla spent several years developing drugs at Abbott Laboratories, a pharmaceutical company where she holds a patent for a drug formulation.

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Editor’s Top Picks

• Muscle Relaxants: List of Common Muscle Relaxers

• Opioid Pain Medications

• Anti-Inflammatory Medications for Back Pain Relief Video

• Medications for Back Pain Video

• Treatment for Back Pain Flare-Ups Video

Motrin tablets 250mg 20pcs at the price of #SEO_PRICE# rubles – prices in Magnit-Pharmacy

Content:

• Active ingredient (lat)
• Presentation form
• Quantity of the drug in the package

900 05 Description of dosage form

• Pharmacokinetics
• Indications
• Special instructions
• Contraindications
• Side effects
• Overdose
• Pregnancy/breastfeeding
• Method of application
• Drug interaction
• Pharmacodynamics
• Precautions
• Influence on the ability to drive vehicles and mechanisms
• Pharmacotherapeutic group
• Vacation
• Package type
• MKB10
• Name/Brand
• Registration number

Active ingredient (lat)

Naproxenum

Release form

Tablets

Quantity of the medicinal product in the package

20

Description of the dosage form

Tablets

Pharmacokinetics

Absorption from the gastrointestinal tract – fast and complete, bioavailability – 95% (food intake practically does not affect either completeness or absorption rate). The time to reach the maximum concentration (TCmax) is 2 hours, the connection with plasma proteins is 99%, the half-life (T1 / 2) is 12-15 hours. Metabolism is in the liver to dimethylnaproxen with the participation of the CYP2C9 enzyme system. Clearance – 0.13 ml / min / kg. It is excreted by 98% by the kidneys, 10% of them are excreted unchanged; with bile – 0.5-2.5%. The equilibrium concentration of the drug in plasma (Css) is determined after 2-3 days. In chronic renal failure, accumulation of metabolites is possible.

Indications of the drug

Pain syndrome of mild and moderate severity: neuralgia, ossalgia, myalgia, lumboischialgia, post-traumatic pain syndrome (sprains and bruises), accompanied by inflammation, postoperative pain (in traumatology, orthopedics, gynecology, maxillofacial surgery), headache, migraine, algodismenorrhea, adnexitis, toothache. Symptomatic therapy of pain syndrome in diseases of the musculoskeletal system, including bursitis, tendovaginitis. As part of the complex therapy of infectious and inflammatory diseases of the ear, throat, nose with severe pain syndrome (pharyngitis, tonsillitis, otitis media). Feverish conditions with influenza and colds. The drug is used for symptomatic therapy (to reduce pain, inflammation and reduce elevated body temperature) and does not affect the progression of the underlying disease.

special instructions

Do not exceed the recommended dosage.

To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used for the shortest possible course. If pain and fever persist or become worse, the patient should consult a doctor.

Patients with bronchial asthma, bleeding disorders, as well as patients with hypersensitivity to other analgesics should consult a doctor before taking naproxen.

With caution, the drug should be prescribed to patients with liver disease and renal failure. In patients with renal insufficiency, CC should be monitored. In chronic alcoholic cirrhosis and other forms of cirrhosis of the liver, the concentration of unbound naproxen is increased, so lower doses are recommended in these patients.

Naproxen should not be taken with other anti-inflammatory or pain medications unless directed by a doctor.

Elderly patients are also recommended lower doses of the drug.

Naproxen should be avoided for 48 hours prior to surgery.

If it is necessary to determine 17-corticosteroids, the drug should be discontinued 48 hours before the study. Similarly, naproxen may interfere with the determination of 5-hydroxyindoleacetic acid in the urine.

The use of naproxen, as well as other drugs that block the synthesis of prostaglandins, can affect fertility, therefore it is not recommended for women planning a pregnancy

Contraindications

Hypersensitivity to naproxen or naproxen sodium; complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (including history). During coronary artery bypass grafting. Erosive and ulcerative lesions of the stomach and duodenum in the acute phase (ulcerative colitis (UC), Crohn’s disease). Cerebrovascular bleeding or other bleeding and violations of hemostasis. Severe renal failure (creatinine clearance less than 30 ml / min), incl. confirmed hyperkalemia, progressive kidney disease. Inhibition of bone marrow hematopoiesis. Pregnancy, breastfeeding period. Children’s age up to 12 years.

Side effects

Side effects most often develop when using the drug in high doses.
From the digestive system: constipation, abdominal pain, dyspepsia, nausea, diarrhea, ulcerative stomatitis, erosive and ulcerative lesions and bleeding of the gastrointestinal tract, NSAID gastropathy (lesion of the antrum of the stomach in the form of erythema of the mucous membrane, hemorrhages, erosions and ulcers), increased activity of liver enzymes, abnormal liver function, jaundice, hematemesis, melena.
From the side of the central nervous system: dizziness, headache, drowsiness, depression, sleep disturbances, inability to concentrate, insomnia, malaise, slow psychomotor reactions, aseptic meningitis, cognitive dysfunction.
From the senses: hearing loss, tinnitus, hearing impairment, visual impairment.
From the side of the cardiovascular system: swelling of the face and extremities, shortness of breath, palpitations, the occurrence or aggravation of existing chronic heart failure, vasculitis.
From the respiratory system: eosinophilic pneumonitis.
From the urinary system: glomerulonephritis, hematuria, interstitial nephritis, nephrotic syndrome, renal failure, renal papillary necrosis;
From the reproductive system: menstrual irregularities.
From the hematopoietic system: eosinophilia, granulocytopenia, leukopenia, thrombocytopenia, aplastic anemia, hemolytic anemia.
From the skin: itching, ecchymosis, excessive sweating, purpura, alopecia, photodermatosis.
Allergic reactions: skin rash, urticaria, angioedema, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome.
Other: thirst, hyperthermia, hyperglycemia, hypoglycemia, myalgia and muscle weakness.

Overdose

A significant overdose of the drug may be characterized by drowsiness, dyspeptic disorders (heartburn, nausea and vomiting, abdominal pain), weakness, tinnitus, irritability, in severe cases – hematemesis, melena, impaired consciousness, convulsions and renal failure

Use during pregnancy/breastfeeding

a:2:{s:4:”TEXT”;s:139:”The use of the drug during pregnancy and lactation is contraindicated. “;s:4:”TYPE”;s:4:”HTML”;}

Mode of application

By mouth, adults and children over 12 years of age. Tablets should be taken whole with a sufficient amount of liquid, can be taken with meals.
For pain relief, the initial dose is 500 mg, then, if necessary, 500 mg every 12 hours or 250 mg every 8 hours.
The usual daily dose used for pain relief is 500-1000 mg.
To relieve pain in migraine, a dose of 500 mg twice a day is recommended. However, treatment should be discontinued if the frequency, intensity and duration of migraine attacks do not decrease within 4-6 weeks.
For the relief of menstrual pain, pain after insertion of an intrauterine device and other gynecological pain (adnexitis), the initial dose is 500 mg, then, if necessary, 250 mg every 6-8 hours for 3-4 days.
For symptomatic treatment of pain in diseases of the musculoskeletal system (bursitis, tendovaginitis), the usual daily dose of the drug is 500-1000 mg, one or two tablets twice a day in the morning and evening.
When using the drug as an antipyretic, the initial dose is 500 mg, then, if necessary, 250 mg every 8 hours.
The drug is not recommended for use as an anesthetic for more than 5 days without consulting a doctor. If symptoms persist, a doctor should be consulted.

drug interaction

When treating with anticoagulants, it should be borne in mind that naproxen may increase bleeding time.

Do not use the drug simultaneously with other NSAIDs (increased risk of side effects).

With simultaneous use with hydantoin derivatives, anticoagulants or other drugs that bind to a large extent with plasma proteins, the effect of these drugs may be potentiated.

Naproxen may reduce the antihypertensive effect of propranolol and other beta-blockers, and may also increase the risk of renal failure associated with the use of ACE inhibitors.

Under the action of naproxen, the natriuretic effect of furosemide is inhibited.

Inhibition of renal clearance of lithium leads to an increase in plasma lithium concentration.

Taking probenecid increases the plasma concentration of naproxen.

Cyclosporine increases the risk of developing kidney failure.

Naproxen slows down the excretion of methotrexate, phenytoin, sulfonamides, increasing the risk of developing their toxic effects.

Antacids containing magnesium and aluminum reduce the absorption of naproxen

Pharmacodynamics

Non-steroidal anti-inflammatory drug (NSAID), has anti-inflammatory, analgesic and antipyretic effects associated with non-selective suppression of the activity of cyclooxygenase 1 and cyclooxygenase 2, which regulate the synthesis of prostaglandins.

Precautionary measures

a:2:{s:4:”TYPE”;s:4:”HTML”;s:4:”TEXT”;s:4023:”Do not exceed the recommended dosage.
To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used for the shortest possible course. If pain and fever persist or become worse, the patient should consult a doctor.
Before taking Motrin®, patients with bronchial asthma, bleeding disorders, as well as patients with hypersensitivity to other analgesics should consult a doctor.
With caution, the drug should be prescribed to patients with liver disease and renal failure. In patients with renal insufficiency, CC should be monitored. With CC less than 30 ml / min, the use of naproxen is not recommended. In chronic alcoholic cirrhosis and other forms of cirrhosis of the liver, the concentration of unbound naproxen is increased, so lower doses are recommended in these patients.
After two weeks of using the drug, monitoring of liver function parameters is necessary.
Motrin should not be taken with other anti-inflammatory and pain medications unless directed by a physician.
Elderly patients (≥ 65 years) are also recommended lower doses of the drug.
Naproxen should be avoided for 48 hours prior to surgery.
If it is necessary to determine 17-corticosteroids, the drug should be discontinued 48 hours before the study. Similarly, naproxen may interfere with the determination of 5-hydroxyindoleacetic acid in the urine.
The use of naproxen, as well as other drugs that block the synthesis of prostaglandins, can affect fertility, so it is not recommended for women planning a pregnancy.
If the medicinal product has become unusable or the expiration date has expired, it should not be thrown into wastewater. It is necessary to place the drug in a bag and put it in a trash container. These measures will help protect the environment.
Influence on the ability to drive vehicles and mechanisms
Naproxen slows down the reaction rate in patients. This should be taken into account when driving vehicles and performing tasks that require increased attention.”;}

Influence on the ability to drive vehicles and mechanisms

Naproxen slows down the reaction rate in patients. This should be taken into account when driving vehicles and performing tasks that require increased attention.

Pharmacotherapeutic group

Non-steroidal anti-inflammatory drug (NSAID).

Vacation

without prescription

Type of packaging

carton

MKB10

Acute tonsillitis [tonsillitis], Headache, Fever of unknown origin, Salpingitis and oophoritis, Migraine, Purulent and unspecified otitis media, Acute nasopharyngitis [runny nose], Acute pharyngitis, Chronic rhinitis, nasopharyngitis and pharyngitis, Influenza due to an identified influenza virus, Acute pain, Primary dysmenorrhea, Sore throat, Chronic tonsillitis, Other persistent pain, Other specified changes in the teeth and their supporting apparatus, Other bursopathies, Superficial injury of an unspecified area of ​​the body, Acute infection of the upper respiratory tract, unspecified, Synovitis and tendosynovitis, Otalgia, Dislocation, sprain and damage to the capsular-ligamentous apparatus of a joint of an unspecified area of ​​the body, Secondary dysmenorrhea, Soft tissue diseases associated with load, overload and pressure, Radiculopathy, Sciatica, Myalgia, Lumbago with sciatica, Neuralgia and neuritis, unspecified

Name/Brand

Motrin

Registration number

R N002874/01

Sanatorium “Kirov” official website of Yalta

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How to reduce the risk of erosive and ulcerative lesions of the stomach when taking non-steroidal anti-inflammatory drugs

04/25/2023

Gastrointestinal tract

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What is it about?

Non-steroidal anti-inflammatory drugs are among the most commonly used drugs. We often take them for headache, toothache or menstrual pain. Doctors prescribe them for other inflammatory diseases (arthritis, myositis, gout). These are medicines such as Nurofen, Aspirin, Ketorolac, Nimesil, Motrin and so on.

Unfortunately, often patients do not consult a doctor before starting their intake and are not aware of the possible side effects of this pharmacological group of drugs. One of the undesirable effects is an erosive and ulcerative lesion of the stomach. With the right intake of non-steroidal anti-inflammatory drugs, the risk of this complication is significantly reduced. There are also methods of prevention (pharmacological and other) of erosive and ulcerative lesions of the stomach when taking non-steroidal anti-inflammatory drugs, which are very effective and which are discussed in this article.

What should be taken into account?

Non-steroidal anti-inflammatory drugs can cause side effects such as stomach and intestinal upset, an increased risk of bleeding, and worsening of kidney function. Before taking it, you should always consult with your doctor, especially if you have problems with the stomach and / or intestines. You should also tell your doctor about all medications you take, including prescription, over-the-counter, and natural remedies, as this group of medications can interact with many other substances. It is necessary to observe the dosage indicated in the instructions for the drug, and do not exceed it without consulting a doctor.

And most importantly: non-steroidal anti-inflammatory drugs are not recommended to be taken for more than 5 days without consulting a doctor.

In this article:

1. What are non-steroidal anti-inflammatory drugs? What is their mechanism of action and where are they used?

2. The relevance of the occurrence of erosive and ulcerative lesions of the stomach when taking non-steroidal anti-inflammatory drugs

3. Why do non-steroidal anti-inflammatory drugs cause damage to the gastric mucosa?

4. Risk factors for the development of erosive and ulcerative lesions of the gastrointestinal tract when taking non-steroidal anti-inflammatory drugs

5. Methods for the prevention of erosive and ulcerative lesions of the gastrointestinal tract when taking non-steroidal anti-inflammatory drugs

What are non-steroidal anti-inflammatory drugs? What is their mechanism of action and where are they used?

Non-steroidal anti-inflammatory drugs, also very often referred to as NSAIDs, are a class of medicines that are used to reduce pain, inflammation, and fever.

The mechanism of their action is to block the enzyme that is involved in the formation of prostaglandins – substances that cause pain, inflammation and fever.

Non-steroidal anti-inflammatory drugs are widely used to treat various diseases associated with inflammation and pain. They are used to treat febrile syndrome with SARS and influenza, osteoarthritis, rheumatoid arthritis, gout, inflammation of the ligaments, tendons or joints (bursitis and tendinitis), as well as muscle pain, headache, toothache, menstrual pain.

Unlike steroid drugs (glucocorticosteroids), non-steroidal anti-inflammatory drugs do not contain hormones and do not have a pronounced immunosuppressive effect, which makes them safer for long-term use. Therefore, in their name there is the word non-steroidal. However, like all medicines, they can cause side effects, including an increased risk of stomach ulcers, stomach bleeding and kidney damage, and cardiovascular complications. Therefore, before using these drugs, you should consult your doctor and follow the instructions for use.

The relevance of the occurrence of erosive and ulcerative lesions of the stomach when taking non-steroidal anti-inflammatory drugs

Statistics show that taking non-steroidal anti-inflammatory drugs can increase the risk of developing erosive and ulcerative lesions of the stomach and intestines. Research data indicate that erosive and ulcerative lesions of the gastrointestinal tract develop in 10-30% of patients who take drugs from this pharmacological group.

Among patients who take NSAIDs for more than 6 months, the risk of developing erosive and ulcerative lesions of the stomach increases by 5 times compared with patients who do not take these drugs.

It was also found that older patients have a higher risk of developing erosive and ulcerative lesions of the stomach. About 60% of cases of erosive and ulcerative lesions were registered in patients older than 60 years.

Interestingly, the majority of patients who develop erosive and ulcerative lesions of the stomach while taking non-steroidal anti-inflammatory drugs, the symptoms may be subtle or absent, which makes it difficult to diagnose and treat this complication in a timely manner. Therefore, in order to prevent the development of this formidable complication, it is important to follow the doctor’s recommendations regarding the dosage, duration of administration, and also apply preventive measures.

Why do non-steroidal anti-inflammatory drugs cause damage to the gastric mucosa?

In one paper published in the journal Arthritis Research & Therapy on the interaction of non-steroidal anti-inflammatory drugs with the gastrointestinal tract, the authors discussed the mechanisms by which these drugs affect the stomach wall. As a result, such negative effects of NSAIDs as a violation of the protective properties of the mucous membrane, a decrease in the production of mucus and an increase in the secretion of gastric juice were identified.

The mechanism of action of drugs of this pharmacological group on the stomach is due to the fact that these drugs reduce the synthesis of prostaglandins. These are physiologically active substances that are involved in many important metabolic processes in the body. They play an important role in protecting the stomach and mucous membranes from damage. Prostaglandins are involved in the regulation of blood flow in the gastrointestinal tract, the formation of mucus, which protects the stomach wall from acid and food enzymes, and the formation of bicarbonates, which also help protect the stomach wall from damage. Thus, the mechanism of this complication is formed due to the main mechanism of action of non-steroidal anti-inflammatory drugs, namely, due to the blocking of enzymes and blocking the synthesis of prostaglandins.

Risk factors for the development of erosive and ulcerative lesions of the gastrointestinal tract when taking non-steroidal anti-inflammatory drugs

The main risk factors for the development of this complication when taking non-steroidal anti-inflammatory drugs:

1. Long-term use of NSAIDs. The longer the patient takes these medications, the more likely they are to develop erosions and stomach ulcers.

2. High dose non-steroidal anti-inflammatory drugs

3. Already existing erosion or ulcer of the stomach, or a healed ulcer of the gastrointestinal tract. Patients who have previously had ulcerative lesions of the stomach or intestines are at a higher risk of developing erosive and ulcerative lesions.

4. Elderly age. Older people also have a higher risk of developing stomach ulcers when taking these drugs due to age-related changes in the gastrointestinal tract and decreased kidney function.

5. Acute period of illness

6. Concomitant use of non-steroidal anti-inflammatory drugs with other drugs. For example, when NSAIDs are taken in combination with glucocorticosteroids or anticoagulants

7. genetic factors. Some genetic mutations may increase the risk of developing this complication.

8. Alcohol abuse and smoking

9. Presence of Helicobacter pylori infection. This is a bacterium that leads to inflammation of the stomach (gastritis) and is the cause of the development of erosions, ulcers. The connection of this infection with the development of stomach cancer has been proven.

In a recent article “NSAIDs, Helicobacter pylori, and Pandora’s box” in The Lancet, researchers looked at the relationship between NSAIDs, Helicobacter pylori infection, and erosive and ulcerative lesions of the stomach and duodenum. They indicate that the presence of Helicobacter pylori infection can enhance the negative impact of the drugs we are considering on the gastric mucosa.

Understanding these risk factors can help clinicians design individualized prevention strategies for patients who are taking non-steroidal anti-inflammatory drugs.

Methods for the prevention of erosive and ulcerative lesions of the gastrointestinal tract when taking non-steroidal anti-inflammatory drugs

What are the methods of prevention?

1. Reducing the dose and duration of non-steroidal anti-inflammatory drugs. This is the most effective way to reduce the risk of developing erosive and ulcerative lesions of the stomach when taking these drugs. But it must be borne in mind that this approach may worsen the effectiveness of treatment, so it is necessary to coordinate the dose and duration of administration with the doctor.

2. Taking NSAIDs with food. Taking these drugs with meals may reduce the risk of gastric erosive and ulcerative lesions, as food can reduce their irritant effect. But you should not take these medicines with milk, as milk can slow down the absorption of the medicine.

3. Taken with medications that “protect” the stomach wall from ulcers. These drugs include proton pump inhibitors (Omeprazole, Rabeprazole, etc.) and antacids (Gastal, Rennie, etc.). Proton pump inhibitors reduce the production of gastric acid and thereby reduce the irritating effect of non-steroidal anti-inflammatory drugs on the gastric mucosa, and antacids protect the same mucosa by covering it with a protective film.

4. The use of those non-steroidal anti-inflammatory drugs that narrowly block only one of the enzymes, namely cyclooxygenase-2. These drugs are a relatively new class that only block cyclooxygenase-2, which is responsible for inflammation and pain, but do not affect cyclooxygenase-1, which is required to protect the gastric mucosa. This reduces the risk of developing erosive and ulcerative lesions of the stomach when taking NSAIDs.

5. Testing for Helicobacter pylori infection and its treatment

The choice of method for the prevention of erosive and ulcerative lesions when taking non-steroidal anti-inflammatory drugs should be carried out by a doctor, taking into account the individual characteristics of the patient and the characteristics of the drug.

Some patients at increased risk of gastric erosive and ulcerative lesions while taking these drugs, such as the elderly or patients with previous gastric and intestinal ulcers, may require more intensive prophylaxis. In such cases, a combination of different methods of prevention or the choice of a treatment method in favor of other drugs may be recommended.

Finally, it is important to understand that the prevention of erosive and ulcerative lesions of the stomach when taking non-steroidal anti-inflammatory drugs is not an absolute guarantee against the development of side effects. If you experience symptoms such as abdominal pain or bleeding, you should consult a doctor.

The Kirov Sanatorium has its own unique diagnostic and treatment base, equipped with modern equipment.

The effectiveness of spa treatment depends on accurate diagnosis and correct diagnosis.

In the laboratory of the sanatorium, differential diagnostics of gastrointestinal diseases is carried out.