How does clotrimazole troche work as an antifungal medication. What are the common uses and side effects of Mycelex oral lozenges. When should you take clotrimazole troches and what precautions are important.

Understanding Clotrimazole Troche: An Antifungal Oral Medication

Clotrimazole troche, also known by the brand name Mycelex Troche, is an antifungal medication used to treat fungal infections in the mouth and throat. It comes in the form of an oral lozenge that slowly dissolves in the mouth, releasing the active ingredient to combat fungal growth on mucous membranes.

This medication belongs to a class of drugs called azole antifungals. It works by preventing fungi from producing ergosterol, an essential component of fungal cell membranes. Without ergosterol, the fungal cells become leaky and eventually die off.

Key Facts About Clotrimazole Troche:

• Generic name: Clotrimazole
• Brand name: Mycelex Troche
• Form: Oral lozenge
• Drug class: Azole antifungal
• Available by prescription only

Primary Uses and Indications for Clotrimazole Troches

Clotrimazole troches are primarily prescribed to treat oropharyngeal candidiasis, a fungal infection commonly known as thrush. This condition occurs when there is an overgrowth of Candida albicans yeast in the mouth and throat.

Can clotrimazole troches be used for other conditions? While primarily indicated for oral thrush, healthcare providers may sometimes prescribe clotrimazole troches for other fungal infections affecting the mouth and throat. However, it’s crucial to use this medication only as directed by a medical professional.

Common Indications for Clotrimazole Troche:

• Oral thrush (oropharyngeal candidiasis)
• Prevention of oral thrush in high-risk patients
• Treatment of certain other oral fungal infections

Proper Administration and Dosage Guidelines

The effectiveness of clotrimazole troches depends on proper administration. These lozenges are designed to dissolve slowly in the mouth, allowing the medication to coat the affected areas.

How should you take clotrimazole troches? Typically, adults and children over 3 years old are instructed to dissolve one troche in the mouth 5 times daily for 14 days. However, dosage may vary based on the severity of the infection and individual patient factors.

Important Administration Tips:

1. Allow the troche to dissolve slowly in the mouth
2. Do not chew or swallow the lozenge whole
3. Take as directed, even if symptoms improve before the full course is complete
4. If you miss a dose, take it as soon as you remember, unless it’s almost time for the next dose

Potential Side Effects and Adverse Reactions

While clotrimazole troches are generally well-tolerated, some patients may experience side effects. Most side effects are mild and tend to resolve on their own as the body adjusts to the medication.

Do clotrimazole troches cause serious side effects? Serious side effects are rare but can occur. It’s important to be aware of potential adverse reactions and seek medical attention if you experience any concerning symptoms.

Common Side Effects:

• Nausea or upset stomach
• Unpleasant taste in the mouth
• Burning or irritation in the mouth
• Increased liver enzyme levels (rarely)

Rare but Serious Side Effects:

• Severe allergic reactions (anaphylaxis)
• Liver problems
• Stevens-Johnson syndrome

If you experience any signs of a severe allergic reaction, such as difficulty breathing, swelling of the face or throat, or severe skin reactions, seek immediate medical attention.

Drug Interactions and Precautions

Clotrimazole troches may interact with other medications, potentially altering their effectiveness or increasing the risk of side effects. It’s crucial to inform your healthcare provider about all medications, supplements, and herbal products you are taking.

Are there specific medications that interact with clotrimazole troches? Some medications that may interact with clotrimazole include certain antihypertensive drugs, anticoagulants, and medications metabolized by the liver enzyme CYP3A4.

Medications That May Interact with Clotrimazole:

• Warfarin and other blood thinners
• Certain antihypertensive medications
• Some HIV medications
• Certain antidepressants

Additionally, pregnant women should consult their healthcare provider before using clotrimazole troches, as the safety of this medication during pregnancy has not been fully established.

Comparison with Other Antifungal Treatments

Clotrimazole troches are one of several treatment options for oral thrush and other fungal infections of the mouth and throat. Understanding how this medication compares to alternatives can help patients and healthcare providers make informed decisions.

How does clotrimazole troche compare to nystatin? Both medications are used to treat oral thrush, but they differ in their mechanism of action and administration. Clotrimazole is an azole antifungal, while nystatin is a polyene antifungal. Nystatin is often available as a swish-and-swallow suspension, while clotrimazole comes in lozenge form.

Comparison of Common Oral Antifungal Treatments:

• Clotrimazole troche: Dissolves slowly in the mouth, typically used 5 times daily
• Nystatin suspension: Swished in the mouth and swallowed, usually 4 times daily
• Fluconazole: Oral tablet taken once daily, often used for more severe or resistant cases

The choice between these treatments depends on factors such as the severity of the infection, patient preferences, and potential drug interactions.

Special Considerations for Immunocompromised Patients

Immunocompromised individuals, such as those with HIV/AIDS or undergoing chemotherapy, are at higher risk for developing oral thrush and may require special considerations when using clotrimazole troches.

Why are immunocompromised patients more susceptible to oral thrush? A weakened immune system makes it harder for the body to control the growth of Candida fungi, leading to a higher risk of infection and potentially more severe or recurring cases of thrush.

Important Points for Immunocompromised Patients:

• May require longer treatment courses or higher doses
• Might need prophylactic treatment to prevent recurrence
• Should be monitored closely for signs of systemic fungal infections
• May need combination therapy with other antifungal medications

Healthcare providers may recommend additional measures to support oral health and prevent fungal overgrowth in immunocompromised patients, such as maintaining good oral hygiene and using sugar-free gum to stimulate saliva production.

Long-term Use and Resistance Concerns

While clotrimazole troches are effective for treating oral thrush, long-term or repeated use may raise concerns about antifungal resistance. Understanding these risks is crucial for both patients and healthcare providers.

Can fungi become resistant to clotrimazole? Like other antimicrobial agents, fungi can develop resistance to clotrimazole over time, especially with prolonged or improper use. This resistance can make future infections more difficult to treat.

Strategies to Minimize Resistance Risk:

1. Complete the full course of treatment as prescribed
2. Avoid using antifungal medications prophylactically unless directed by a healthcare provider
3. Address underlying factors that may contribute to recurrent infections
4. Consider rotating different antifungal medications for recurring cases

Healthcare providers should carefully weigh the benefits and risks of long-term antifungal therapy, particularly in patients prone to recurrent infections.

Availability and Cost Considerations

Clotrimazole troches are available by prescription only in many countries. The cost can vary depending on factors such as brand versus generic versions, insurance coverage, and local pricing.

Is there a significant price difference between brand-name and generic clotrimazole troches? Generic versions of clotrimazole troches are typically more affordable than brand-name products like Mycelex Troche. However, the active ingredient and effectiveness should be the same.

Factors Affecting Cost and Availability:

• Insurance coverage and formulary status
• Availability of generic versions
• Pharmacy pricing and discounts
• Prescription drug assistance programs

Patients concerned about the cost of their medication should discuss options with their healthcare provider or pharmacist. There may be ways to reduce out-of-pocket expenses, such as using pharmacy discount cards or exploring patient assistance programs.

Clotrimazole (Generic for Mycelex Troches, Oral Lozenge)

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Clotrimazole, Oral – Tufts Medical Center Community Care

What are other names for this medicine?

Type of medicine: antifungal

Generic and brand names: clotrimazole, oral; Mycelex Troche (lozenge)

What is this medicine used for?

This medicine is taken by mouth to treat thrush (a fungus infection of the mouth and throat). It may also be used to prevent and treat infections in people with weakened immune systems, such as those receiving chemotherapy or radiation therapy.

This medicine may be used to treat other conditions as determined by your healthcare provider.

What should my healthcare provider know before I take this medicine?

Before taking this medicine, tell your healthcare provider if you have ever had:

• An allergic reaction to any medicine
• Liver disease

Females of childbearing age: Talk with your healthcare provider if you are pregnant or plan to become pregnant. It is not known whether this medicine will harm an unborn baby. Do not breast-feed while taking this medicine without your healthcare provider’s approval.

How do I take it?

Check the label on the medicine for directions about your specific dose. Take this medicine exactly as your healthcare provider prescribes. Do not take more or less or take it longer than prescribed. Do not stop taking this medicine without your healthcare provider’s approval. Fungus infections take time to clear up, so you may need to take this medicine for 2 weeks or more.

Check with your healthcare provider before using this medicine in children under age 3.

Allow the lozenge to dissolve slowly in your mouth until it is gone (usually 15 to 30 minutes). Do not chew it or swallow it whole. If the medicine is swallowed whole or chewed, it causes stomach upset, nausea, and diarrhea.

What if I miss a dose?

Do not miss doses. If you miss a dose, take it as soon as you remember unless it is almost time for the next scheduled dose. In that case, skip the missed dose and take the next one as directed. Do not take double doses. If you are not sure of what to do if you miss a dose, or if you miss more than one dose, contact your healthcare provider.

What if I overdose?

Symptoms of an acute overdose have not been reported.

What should I watch out for?

You may need to have blood tests regularly to see how this medicine affects you. Keep all appointment for these tests.

If your symptoms do not improve in a few days or if they get worse, contact your healthcare provider.

If you need emergency care, surgery, or dental work, tell the healthcare provider or dentist you are taking this medicine.

What are the possible side effects?

Along with its needed effects, your medicine may cause some unwanted side effects. Some side effects may be very serious. Some side effects may go away as your body adjusts to the medicine. Tell your healthcare provider if you have any side effects that continue or get worse.

Life-threatening (Report these to your healthcare provider right away. If you cannot reach your healthcare provider right away, get emergency medical care or call 911 for help): Allergic reaction (hives; itching; rash; trouble breathing; tightness in your chest; swelling of your lips, tongue, and throat).

Serious (report these to your healthcare provider right away): Yellowing of skin or eyes, white patches in the mouth, fever, chills, vaginal itching or discharge, unexplained tiredness, unhealed wounds and sores, severe stomach pain.

Other: Nausea, vomiting, mild itching.

What products might interact with this medicine?

When you take this medicine with other medicines, it can change the way this or any of the other medicines work. Nonprescription medicines, vitamins, natural remedies, and certain foods may also interact. Using these medicines together might cause harmful side effects. Talk to your healthcare provider if you are taking:

• Immunosuppressants such as cyclosporine (Sandimmune, Neoral, Gengraf), sirolimus (Rapamune), and tacrolimus (Prograf, Protopic)

If you are not sure if your medicines might interact, ask your pharmacist or healthcare provider. Keep a list of all your medicines with you. List all the prescription medicines, nonprescription medicines, supplements, natural remedies, and vitamins that you take. Be sure that you tell all healthcare providers who treat you about all the products you are taking.

How should I store this medicine?

Store this medicine at room temperature. Keep the container tightly closed. Protect it from heat, high humidity, and bright light.

This advisory includes selected information only and may not include all side effects of this medicine or interactions with other medicines. Ask your healthcare provider or pharmacist for more information or if you have any questions.

Ask your pharmacist for the best way to dispose of outdated medicine or medicine you have not used. Do not throw medicine in the trash.

Keep all medicines out of the reach of children.

Do not share medicines with other people.

Medication Advisor 2015.1 published by RelayHealth.
Last modified: 2014-12-01
Last reviewed: 2014-12-01

This content is reviewed periodically and is subject to change as new health information becomes available. The information is intended to inform and educate and is not a replacement for medical evaluation, advice, diagnosis or treatment by a healthcare professional.

Copyright ©1986-2015 McKesson Corporation and/or one of its subsidiaries. All rights reserved.

Mycelex (Clotrimazole) Side Effects, Images, Usage, Dosage, Overdose in RxList

Mycelex

• Generic Name: Clotrimazole
• Brand Name: Mycelex

• Pictures and Side Effects
• How to Take
• Avoid Taking Mycelex patients, including side effects

  Brand names: Mycelex Troche

  Generic name: clotrimazole

  • What is clotrimazole (Mycelex Troche)?
  • What are the possible side effects of clotrimazole (Mycelex Troche)?
  • What is the most important information I should know about clotrimazole (Mycelex Troche)?
  • What should I discuss with my doctor before taking clotrimazole (Mycelex Troche)?
  • How do I take clotrimazole (Mycelex Troche)?
  • What happens if I miss a dose (Mycelex Troche)?
  • What happens if I overdose (Mycelex Troche)?
  • What should I avoid while taking clotrimazole (Mycelex Troche)?
  • What other drugs will affect clotrimazole (Mycelex Troche)?
  • Where can I get more information (Mycelex Troche)?

  What is clotrimazole (Mycelex Troche)?

  Clotrimazole is an antifungal drug. It is similar to an antibiotic but is used to treat yeast (fungal) infections.

  Clotrimazole is used by mouth to treat and prevent yeast infections in the mouth and throat.

  Clotrimazole may also be used for purposes other than those listed in this medication guide.

  What are the possible side effects of clotrimazole (Mycelex Troche)?

  maximum daily dose of Adderall XR

  Stop taking clotrimazole and get emergency medical help if you have an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives).

  When taking clotrimazole, side effects are unlikely. Continue taking clotrimazole and talk to your doctor if you experience

  • nausea or upset stomach,
  • vomiting,
  • itching, or
  • bad feeling in your mouth.

  Side effects other than those listed here may also occur. Talk to your doctor about any side effects that seem unusual or are of particular concern. You can report side effects to the FDA at 1-800-FDA-1088.

  What is the most important information I should know about clotrimazole (Mycelex Troche)?

  Take all your prescribed clotrimazole, even if you feel better. Your symptoms may improve before the infection is completely cleared.

  Mycelex patient information, including how I should take

  What should I discuss with my doctor before taking clotrimazole (Mycelex Troche)?

  Tell your doctor if you have liver disease before taking this medicine. You may not be able to take clotrimazole, or you may need a lower dose or special monitoring during your treatment.

  Clotrimazole is not absorbed through the stomach. It does not treat fungal infections in any part of your body other than your mouth and throat. Talk to your doctor if you have another type of fungal infection, such as athlete’s foot, itching, ringworm, or a vaginal yeast infection.

  Oral clotrimazole is FDA Pregnancy Category C. This means that it is not known whether clotrimazole will harm an unborn baby. Do not take this medicine without first talking to your doctor if you are pregnant.

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  It is not known if clotrimazole will harm a nursing baby. Do not take this medicine without first talking to your doctor if you are breastfeeding a baby.

  The safety and efficacy of clotrimazole in children under 3 years of age have not been established.

  How do I take clotrimazole (Mycelex Troche)?

  Take clotrimazole as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse or doctor to explain them to you.

  The mouth should slowly dissolve in the mouth. Suck on one paste at a time until it is completely dissolved, usually 30 minutes.

  Junel Fe 1 20 missed tablet

  Do not chew or swallow lozenges whole.

  Lozenges are usually used five times a day. Follow your doctor’s instructions.

  Store clotrimazole at room temperature away from moisture and heat.

  Mycelex patient information, including missed dose

  What happens if I miss a dose (Mycelex Troche)?

  Take the missed dose as soon as you remember. However, if it’s time to take your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medicine unless your doctor tells you otherwise.

  What happens if I overdose (Mycelex Troche)?

  Seek emergency medical attention.

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  Symptoms of an overdose of clotrimazole are unknown.

  What should I avoid while taking clotrimazole (Mycelex Troche)?

  There are no restrictions on food, drink, or activities during treatment with clotrimazole, unless your doctor tells you otherwise.

  What other drugs will affect clotrimazole (Mycelex Troche)?

  Since clotrimazole is not absorbed into the body, interactions with other drugs are not expected. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines.

  Where can I get more information (Mycelex Troche)?

  Your pharmacist has additional information about clotrimazole written for healthcare professionals that you can read.

  ---

  Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only as directed. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. is accurate, current and complete. (“Multum”), but no guarantees are given in this regard. The information contained herein about the drug may vary over time. Multum’s information has been collected for use by clinicians and consumers in the United States, and therefore Multum does not warrant that use outside of the United States is appropriate unless specifically stated otherwise. Multum’s drug information does not contain recommendations for drugs, patient diagnosis, or treatment. Multum Drug Information is an information resource designed to assist licensed practitioners in caring for their patients and/or serving consumers who view this service as an addition to, and not a substitute for, the experience, skills, knowledge, and judgment of practitioners. The absence of a warning for a given drug or drug combination should in no way be construed as an indication that the drug or drug combination is safe, effective or suitable for any given patient. Multum assumes no responsibility for any aspects of health care managed by the information provided by Multum. The information contained in this document is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or side effects. If you have any questions about the medicines you are taking, check with your doctor, nurse or pharmacist.

  Copyright 1996-2019 Cerner Multum, Inc.

  Mycelex (Clotrimazole): Uses, Dosage, Side Effects, Interactions, Warning

  • Generic Name: Clotrimazole
  • Brand Name: Mycelex
  • Product Description
  • Indications

  900 11 Dosage

  • Side effects and drug interactions
  • Warnings and Precautions
  • Overdose and Contraindications
  • Clinical Pharmacology
  • Medication Guide

  Product Description

  MYCELEX
  (clotrimazole) SOME 90 003

  FOR TOPICAL ORAL ADMINISTRATION

  DESCRIPTION

  Each Mycelex Troche contains 10 mg of clotrimazole [1 – (o-chloro-α, α-diphenylbenzyl) imidazole], a synthetic antifungal agent for topical use in the oral cavity.

  Structural formula:

  bupropion xl 300 mg side effects

  Chemical formula of : C

  The lozenge dosage form is a large slow-dissolving tablet (lozenge) containing 10 mg of clotrimazole dispersed in dextrose, microcrystalline cellulose, povidone and magnesium stearate.

  Indications

  INDICATIONS

  Mycelex Troches is indicated for the topical treatment of oropharyngeal candidiasis. Diagnosis must be confirmed by KOH smear and/or culture prior to treatment.

  Mycelex Troches is also indicated prophylactically to reduce the incidence of oropharyngeal candidiasis in immunocompromised patients due to conditions that include chemotherapy, radiation therapy, or steroid therapy used in the treatment of leukemia, solid tumors, or kidney transplantation. There are no adequate and well-controlled trial data to establish the safety and efficacy of this product for prophylactic use in immunocompromised patients with etiologies other than those listed in the previous sentence. (See DOSAGE AND ADMINISTRATION .)

  Dosage

  DOSAGE AND ADMINISTRATION

  Mycelex Troches is only administered as lozenges that must be slowly dissolved in the mouth. The recommended dose is one paste five times a day for fourteen consecutive days. There are only limited data on the safety and efficacy of clotrimazole after long-term use; therefore, if possible, therapy should be limited to short-term use.

  For prophylaxis aimed at reducing the incidence of oropharyngeal candidiasis in patients who are immunocompromised due to conditions that include chemotherapy, radiation therapy, or steroid therapy used in the treatment of leukemia, solid tumors, or kidney transplantation, the recommended dose is one xhashka three times per day during chemotherapy or until steroids are reduced to maintenance levels.

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  HOW SUPPLIED

  Mycelex Troches, uncoated white discoid tablets are available in vials of 70 and 140. Mycelex Troches are also available for use in healthcare facilities in foil packs of 70 tablets. Each tablet will be identified as follows: Mycelex 10.

  	Strength	NDC Code	Tablet Identification
  Bottles of 7 0:	10 mg	NDC 17314-9400-1	MYCELEX 10
  Bottles 140:	10mg	NDC 17314-9400-3	MYCELEX 10
  Standard dose package 70:	10 mg	NDC 17314-9400-2	MYCELEX 10

  Store below 86°F (30°C).
  Avoid freezing.

  yeast infection remedy increases itching

  Manufacturer: Bayer Corporation West Haven, CT 06516 Distributed by ALZA Pharmaceuticals A, a division of ALZA Corporation Mountain View, CA 94043

  Adverse effects and drug interactions

  SIDE EFFECTS

  Abnormal liver function tests have been reported in patients treated with clotrimazole; elevated SGOT levels have been reported in approximately 15% of patients in clinical trials (see PRECAUTIONS section ).

  Nausea, vomiting, mouth discomfort and itching have also been reported with choe.

  Drug abuse and dependence

  Data not available.

  DRUG INTERACTIONS

  No information provided.

  Warnings and Precautions

  WARNINGS

  Mycelex Troches are not indicated for the treatment of systemic fungal infections, including systemic candidiasis.

  PRECAUTIONS

  Abnormal liver function tests have been reported in patients treated with clotrimazole; elevated SGOT levels have been reported in approximately 15% of patients in clinical trials. In most cases, the increase was minimal, and it was often impossible to distinguish the effects of clotrimazole from the effects of other therapy and the underlying disease (in most cases, malignant neoplasms). Periodic evaluation of liver function is recommended, especially in patients with pre-existing liver failure.

  Since patients must be instructed to dissolve each paste slowly in the mouth to achieve the maximum effect of the drug, they must be of age and physical and/or mental condition to understand such instructions.

  Carcinogenesis

  An 18-month dose study of clotrimazole in rats showed no carcinogenic effect.

  Use during pregnancy

  Pregnancy category C : Clotrimazole has been shown to be embryotoxic in rats and mice when administered at doses up to 100 times the adult human dose (in mg/kg), possibly secondary to maternal toxicity. The drug did not have a teratogenic effect on mice, rabbits and rats when administered at doses 200, 180 and 100 times the human dose.

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  Clotrimazole administered orally to mice nine weeks prior to mating through weaning at 120 times the human dose was associated with mating failure, reduced viable pups, and decreased survival to weaning. At 60 times the human dose, no effects were observed. When the drug was administered to rats for a similar period of time at a dose of 50 times the human dose, there was a slight decrease in the number of pups in the litter and a decrease in the viability of the pups.

  There are no adequate and well-controlled studies in pregnant women. Clotrimazole tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

  Pediatric use

  The safety and efficacy of clotrimazole in children under 3 years of age have not been established; therefore, its use in such patients is not recommended.

  The safety and efficacy of prophylactic use of clotrimazole in children has not been established.

  Geriatric Use

  Clinical studies of clotrimazole did not include sufficient numbers of subjects aged 65 years and over to determine if they differed from younger subjects. Other reported clinical experience has found no difference in response between older and younger patients.

  Overdose and contraindications

  OVERDOSAGE

  Data not available.

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  CONTRAINDICATIONS

  Mycelex Troches is contraindicated in patients with hypersensitivity to any of its ingredients.

  Clinical Pharmacology

  CLINICAL PHARMACOLOGY

  Clotrimazole is a broad spectrum antifungal agent that inhibits the growth of pathogenic yeasts by altering the permeability of cell membranes. The action of clotrimazole is fungistatic at drug concentrations up to 20 µg/ml and may be fungicidal. in vitro against Candida albicans and other Candida species at higher concentrations. During successive passages of Candida albicans in the laboratory, one-stage or multi-stage resistance to clotrimazole did not develop; however, individual organism tolerance was observed during successive passages in the laboratory. Such in vitro tolerance disappeared after the organism was removed from the antifungal medium.

  Following oral administration of a 10 mg clotrimazole lozenge to healthy volunteers, concentrations sufficient to suppress most Candida species persist in saliva for up to three hours after approximately 30 minutes for the paste to dissolve. The prolonged presence of the drug in saliva appears to be due to the slow release of clotrimazole from the oral mucosa to which the drug appears to be associated. Repeated dosing at three-hour intervals maintains salivary levels above the minimum inhibitory concentrations of most Candida strains; however, the relationship between in vitro The susceptibility of pathogenic fungi to clotrimazole and the prevention or treatment of infections in humans have not been established.