What You Want to Know

We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.

Healthline only shows you brands and products that we stand behind.

Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:

• Evaluate ingredients and composition: Do they have the potential to cause harm?
• Fact-check all health claims: Do they align with the current body of scientific evidence?
• Assess the brand: Does it operate with integrity and adhere to industry best practices?

We do the research so you can find trusted products for your health and wellness.

Read more about our vetting process.

Was this helpful?

Pepto-Bismol may help relieve diarrhea, upset stomach, and other digestive symptoms.

Chances are you’ve heard of “the pink stuff. ” Pepto-Bismol is a well-known over-the-counter medication used to treat digestive problems.

If you’re feeling a bit queasy, read on to learn what to expect when taking Pepto-Bismol and how to use it safely.

Pepto-Bismol is used to treat diarrhea and relieve the symptoms of an upset stomach. These symptoms can include:

• heartburn
• nausea
• indigestion
• gas
• belching
• a feeling of fullness

The active ingredient in Pepto-Bismol is called bismuth subsalicylate. It belongs to a drug class called salicylates.

Pepto-Bismol is available in regular strength as a caplet, chewable tablet, and liquid. It’s available in maximum strength as a liquid and caplet. All forms are taken by mouth.

Pepto-Bismol is thought to treat diarrhea by:

• increasing the amount of fluid your intestines absorb
• reducing inflammation and overactivity of your intestines
• preventing your body’s release of a chemical called prostaglandin that causes inflammation
• blocking toxins produced by bacteria such as Escherichia coli
• killing other bacteria that cause diarrhea

The active ingredient, bismuth subsalicylate, also has antacid properties that can help decrease heartburn, upset stomach, and nausea.

Adults and children 12 years and older can take the following forms of Pepto-Bismol for up to 2 days. The dosages below apply for all digestive problems Pepto-Bismol can help treat.

When treating diarrhea, be sure to drink plenty of water to replace lost fluid. Keep drinking fluids even if you’re using Pepto-Bismol.

If your condition lasts longer than 2 days or you have ringing in your ears, stop taking Pepto-Bismol and call your doctor.

Liquid suspension

Original strength:

• Take 30 milliliters (mL) every 30 minutes, or 60 mL every hour as needed.
• Do not take more than eight doses (240 mL) in 24 hours.
• Do not use for more than 2 days. See your doctor if diarrhea lasts longer than this.
• Original Pepto-Bismol liquid also comes in a cherry flavor, both of which have the same dosage instructions.

Pepto-Bismol Ultra (maximum strength):

• Take 15 mL every 30 minutes, or 30 mL every hour as needed.
• Do not take more than eight doses (120 mL) in 24 hours.
• Do not use for more than 2 days. See your doctor if symptoms aren’t improving.
• Pepto-Bismol Ultra also comes in cherry flavor with identical dosage instructions.

Another liquid option is known as Pepto Cherry Diarrhea. This product is designed to only treat diarrhea. It’s not the same product as cherry-flavored Pepto-Bismol Original or Ultra. It’s also for people 12 years and older.

Below is the recommended dosage for Pepto Cherry Diarrhea:

• Take 10 mL every 30 minutes, or 20 mL every hour as needed.
• Do not take more than eight doses (80 mL) in 24 hours.
• Do not use for more than 2 days. See your doctor if diarrhea is still ongoing.

Chewable tablets

For Pepto Chews:

• Take two tablets every 30 minutes, or four tablets every 60 minutes as needed.
• Chew or dissolve the tablets in your mouth.
• Do not take more than eight doses (16 tablets) in 24 hours.
• Stop taking this medication and see your doctor if diarrhea doesn’t subside after 2 days.

Caplets

Original caplets:

• Take two caplets (262 milligrams each) every 30 minutes, or four caplets every 60 minutes as needed.
• Swallow the caplets whole with water. Do not chew them.
• Do not take more than eight caplets in 24 hours.
• Do not use for more than 2 days.
• See your doctor if diarrhea doesn’t subside.

Ultra caplets:

• Take one caplet (525 mg) every 30 minutes, or two caplets every 60 minutes as needed.
• Swallow the caplets with water. Do not chew them.
• Do not take more than eight caplets in 24 hours. Don’t use for more than 2 days.
• See your doctor if diarrhea lasts longer than 2 days.

Pepto Diarrhea caplets:

• Take one caplet every 30 minutes, or two caplets every 60 minutes as needed.
• Swallow the caplets with water. Do not chew them.
• Do not take more than eight caplets in 24 hours.
• Do not take for longer than 2 days. See your doctor if diarrhea lasts beyond this time.

Pepto Original LiquiCaps or Diarrhea LiquiCaps:

• Take two LiquiCaps (262 mg each) every 30 minutes, or four LiquiCaps every 60 minutes as needed.
• Do not take more than 16 LiquiCaps in 24 hours.
• Do not use for more than 2 days. See your doctor if diarrhea lasts longer than this.

For children

The above products and dosages are designed for people 12 years and older. Pepto-Bismol offers a separate product designed for children 12 and under in chewable tablets.

This product is designed to treat heartburn and indigestion in young children. Note that the dosages are based on weight and age.

Pepto Kids Chewable Tablets:

• One tablet for children 24 to 47 pounds and 2 to 5 years of age. Do not exceed three tablets in 24 hours.
• Two tablets for children 48 to 95 pounds and 6 to 11 years of age. Do not exceed six tablets in 24 hours.
• Do not use in children under 2 years old or under 24 pounds, unless recommended by a doctor.
• Call your child’s pediatrician if symptoms don’t improve within 2 weeks.

Most side effects from Pepto-Bismol are mild and go away shortly after you stop taking the medication.

More common side effects

The more common side effects of Pepto-Bismol include:

• black stool
• black, hairy tongue

These side effects are harmless. Both effects are temporary and go away within several days after you stop taking Pepto-Bismol.

Q:

Why can Pepto-Bismol give me black stool and a black, hairy tongue?

Reader-submitted question

A:

Pepto-Bismol contains a substance called bismuth. When this substance mixes with sulfur (a mineral in your body), it forms another substance called bismuth sulfide. This substance is black.

When it forms in your digestive tract, it mixes with food as you digest it. This makes your stool turn black. When bismuth sulfide forms in your saliva, it turns your tongue black. It also causes a buildup of dead skin cells on your tongue’s surface, which can make your tongue look furry.

Healthline Medical TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Was this helpful?

Serious side effect

Ringing in your ears is an uncommon but serious side effect of Pepto-Bismol. If you have this side effect, stop taking Pepto-Bismol and call your doctor right away.

Pepto-Bismol may interact with any other medications you may be taking. Talk to your pharmacist or doctor to see whether Pepto-Bismol interacts with any medications you take.

Examples of medications that can interact with Pepto-Bismol include:

• angiotensin converting enzyme (ACE) inhibitors, such as benazepril, captopril, enalapril, fosinopril, lisinopril, and trandolapril
• anti-seizure drugs, such as valproic acid and divalproex
• blood thinners (anticoagulants), such as warfarin
• diabetes medications, such as insulin, metformin, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors
• gout medications, such as probenecid
• methotrexate
• nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, naproxen, ibuprofen, meloxicam, indomethacin, and diclofenac
• other salicylates, such as aspirin
• phenytoin
• tetracycline antibiotics, such as demeclocycline, doxycycline, minocycline, and tetracycline

Definition

An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

Was this helpful?

Pepto-Bismol is typically safe for most people, but avoid it if you have certain health conditions. Pepto-Bismol may make them worse.

Don’t take Pepto-Bismol if you:

• are allergic to salicylates (including aspirin or NSAIDs such as ibuprofen, naproxen, and celecoxib)
• have an active, bleeding ulcer
• are passing bloody stools or black stools that aren’t caused by Pepto-Bismol
• are a teenager who has or is recovering from chickenpox or flu-like symptoms

Bismuth subsalicylate may also cause problems for people with other health conditions.

Before taking Pepto-Bismol, tell your doctor if you have any of the following medical conditions. They can tell you if it’s safe to use Pepto-Bismol. These conditions include:

• stomach ulcers
• bleeding problems, such as hemophilia and von Willebrand disease
• kidney problems
• gout
• diabetes

Stop taking Pepto-Bismol and call your doctor right away if you have vomiting and extreme diarrhea along with behavior changes, such as:

• loss of energy
• aggressive behavior
• confusion

These symptoms could be early signs of Reye’s syndrome. This is a rare but serious illness that can affect your brain and liver.

Avoid using Pepto-Bismol to self-treat diarrhea if you have a fever or stools that contain blood or mucus. If you have these symptoms, call your doctor right away. They could be signs of a serious health condition, such as an infection.

In case of overdose

Symptoms of a Pepto-Bismol overdose can include:

• ringing in your ears
• loss of hearing
• extreme drowsiness
• nervousness
• fast breathing
• confusion
• seizures

If you think you’ve taken too much, call your doctor or local poison control center. If your symptoms are severe, call 911 or local emergency services, or go to the nearest emergency room right away.

For many people, Pepto-Bismol is a safe, easy way to relieve common stomach problems. But if you have any concerns about whether Pepto-Bismol is a safe option for you, be sure to ask your doctor or pharmacist.

Also call your doctor if Pepto-Bismol doesn’t ease your symptoms after 2 days.

Shop for Pepto-Bismol.

Dosage warning

This product should not be used in children younger than 12 years.

Was this helpful?

What You Want to Know

We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission Here’s our process.

Healthline only shows you brands and products that we stand behind.

Our team thoroughly researches and evaluates the recommendations we make on our site. To establish that the product manufacturers addressed safety and efficacy standards, we:

• Evaluate ingredients and composition: Do they have the potential to cause harm?
• Fact-check all health claims: Do they align with the current body of scientific evidence?
• Assess the brand: Does it operate with integrity and adhere to industry best practices?

We do the research so you can find trusted products for your health and wellness.

Read more about our vetting process.

Was this helpful?

Pepto-Bismol may help relieve diarrhea, upset stomach, and other digestive symptoms.

Chances are you’ve heard of “the pink stuff.” Pepto-Bismol is a well-known over-the-counter medication used to treat digestive problems.

If you’re feeling a bit queasy, read on to learn what to expect when taking Pepto-Bismol and how to use it safely.

Pepto-Bismol is used to treat diarrhea and relieve the symptoms of an upset stomach. These symptoms can include:

• heartburn
• nausea
• indigestion
• gas
• belching
• a feeling of fullness

The active ingredient in Pepto-Bismol is called bismuth subsalicylate. It belongs to a drug class called salicylates.

Pepto-Bismol is available in regular strength as a caplet, chewable tablet, and liquid. It’s available in maximum strength as a liquid and caplet. All forms are taken by mouth.

Pepto-Bismol is thought to treat diarrhea by:

• increasing the amount of fluid your intestines absorb
• reducing inflammation and overactivity of your intestines
• preventing your body’s release of a chemical called prostaglandin that causes inflammation
• blocking toxins produced by bacteria such as Escherichia coli
• killing other bacteria that cause diarrhea

The active ingredient, bismuth subsalicylate, also has antacid properties that can help decrease heartburn, upset stomach, and nausea.

Adults and children 12 years and older can take the following forms of Pepto-Bismol for up to 2 days. The dosages below apply for all digestive problems Pepto-Bismol can help treat.

When treating diarrhea, be sure to drink plenty of water to replace lost fluid. Keep drinking fluids even if you’re using Pepto-Bismol.

If your condition lasts longer than 2 days or you have ringing in your ears, stop taking Pepto-Bismol and call your doctor.

Liquid suspension

Original strength:

• Take 30 milliliters (mL) every 30 minutes, or 60 mL every hour as needed.
• Do not take more than eight doses (240 mL) in 24 hours.
• Do not use for more than 2 days. See your doctor if diarrhea lasts longer than this.
• Original Pepto-Bismol liquid also comes in a cherry flavor, both of which have the same dosage instructions.

Pepto-Bismol Ultra (maximum strength):

• Take 15 mL every 30 minutes, or 30 mL every hour as needed.
• Do not take more than eight doses (120 mL) in 24 hours.
• Do not use for more than 2 days. See your doctor if symptoms aren’t improving.
• Pepto-Bismol Ultra also comes in cherry flavor with identical dosage instructions.

Another liquid option is known as Pepto Cherry Diarrhea. This product is designed to only treat diarrhea. It’s not the same product as cherry-flavored Pepto-Bismol Original or Ultra. It’s also for people 12 years and older.

Below is the recommended dosage for Pepto Cherry Diarrhea:

• Take 10 mL every 30 minutes, or 20 mL every hour as needed.
• Do not take more than eight doses (80 mL) in 24 hours.
• Do not use for more than 2 days. See your doctor if diarrhea is still ongoing.

Chewable tablets

For Pepto Chews:

• Take two tablets every 30 minutes, or four tablets every 60 minutes as needed.
• Chew or dissolve the tablets in your mouth.
• Do not take more than eight doses (16 tablets) in 24 hours.
• Stop taking this medication and see your doctor if diarrhea doesn’t subside after 2 days.

Caplets

Original caplets:

• Take two caplets (262 milligrams each) every 30 minutes, or four caplets every 60 minutes as needed.
• Swallow the caplets whole with water. Do not chew them.
• Do not take more than eight caplets in 24 hours.
• Do not use for more than 2 days.
• See your doctor if diarrhea doesn’t subside.

Ultra caplets:

• Take one caplet (525 mg) every 30 minutes, or two caplets every 60 minutes as needed.
• Swallow the caplets with water. Do not chew them.
• Do not take more than eight caplets in 24 hours. Don’t use for more than 2 days.
• See your doctor if diarrhea lasts longer than 2 days.

Pepto Diarrhea caplets:

• Take one caplet every 30 minutes, or two caplets every 60 minutes as needed.
• Swallow the caplets with water. Do not chew them.
• Do not take more than eight caplets in 24 hours.
• Do not take for longer than 2 days. See your doctor if diarrhea lasts beyond this time.

Pepto Original LiquiCaps or Diarrhea LiquiCaps:

• Take two LiquiCaps (262 mg each) every 30 minutes, or four LiquiCaps every 60 minutes as needed.
• Do not take more than 16 LiquiCaps in 24 hours.
• Do not use for more than 2 days. See your doctor if diarrhea lasts longer than this.

For children

The above products and dosages are designed for people 12 years and older. Pepto-Bismol offers a separate product designed for children 12 and under in chewable tablets.

This product is designed to treat heartburn and indigestion in young children. Note that the dosages are based on weight and age.

Pepto Kids Chewable Tablets:

• One tablet for children 24 to 47 pounds and 2 to 5 years of age. Do not exceed three tablets in 24 hours.
• Two tablets for children 48 to 95 pounds and 6 to 11 years of age. Do not exceed six tablets in 24 hours.
• Do not use in children under 2 years old or under 24 pounds, unless recommended by a doctor.
• Call your child’s pediatrician if symptoms don’t improve within 2 weeks.

Most side effects from Pepto-Bismol are mild and go away shortly after you stop taking the medication.

More common side effects

The more common side effects of Pepto-Bismol include:

• black stool
• black, hairy tongue

These side effects are harmless. Both effects are temporary and go away within several days after you stop taking Pepto-Bismol.

Q:

Why can Pepto-Bismol give me black stool and a black, hairy tongue?

Reader-submitted question

A:

Pepto-Bismol contains a substance called bismuth. When this substance mixes with sulfur (a mineral in your body), it forms another substance called bismuth sulfide. This substance is black.

When it forms in your digestive tract, it mixes with food as you digest it. This makes your stool turn black. When bismuth sulfide forms in your saliva, it turns your tongue black. It also causes a buildup of dead skin cells on your tongue’s surface, which can make your tongue look furry.

Healthline Medical TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Was this helpful?

Serious side effect

Ringing in your ears is an uncommon but serious side effect of Pepto-Bismol. If you have this side effect, stop taking Pepto-Bismol and call your doctor right away.

Pepto-Bismol may interact with any other medications you may be taking. Talk to your pharmacist or doctor to see whether Pepto-Bismol interacts with any medications you take.

Examples of medications that can interact with Pepto-Bismol include:

• angiotensin converting enzyme (ACE) inhibitors, such as benazepril, captopril, enalapril, fosinopril, lisinopril, and trandolapril
• anti-seizure drugs, such as valproic acid and divalproex
• blood thinners (anticoagulants), such as warfarin
• diabetes medications, such as insulin, metformin, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, and sodium-glucose cotransporter-2 (SGLT-2) inhibitors
• gout medications, such as probenecid
• methotrexate
• nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin, naproxen, ibuprofen, meloxicam, indomethacin, and diclofenac
• other salicylates, such as aspirin
• phenytoin
• tetracycline antibiotics, such as demeclocycline, doxycycline, minocycline, and tetracycline

Definition

An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

Was this helpful?

Pepto-Bismol is typically safe for most people, but avoid it if you have certain health conditions. Pepto-Bismol may make them worse.

Don’t take Pepto-Bismol if you:

• are allergic to salicylates (including aspirin or NSAIDs such as ibuprofen, naproxen, and celecoxib)
• have an active, bleeding ulcer
• are passing bloody stools or black stools that aren’t caused by Pepto-Bismol
• are a teenager who has or is recovering from chickenpox or flu-like symptoms

Bismuth subsalicylate may also cause problems for people with other health conditions.

Before taking Pepto-Bismol, tell your doctor if you have any of the following medical conditions. They can tell you if it’s safe to use Pepto-Bismol. These conditions include:

• stomach ulcers
• bleeding problems, such as hemophilia and von Willebrand disease
• kidney problems
• gout
• diabetes

Stop taking Pepto-Bismol and call your doctor right away if you have vomiting and extreme diarrhea along with behavior changes, such as:

• loss of energy
• aggressive behavior
• confusion

These symptoms could be early signs of Reye’s syndrome. This is a rare but serious illness that can affect your brain and liver.

Avoid using Pepto-Bismol to self-treat diarrhea if you have a fever or stools that contain blood or mucus. If you have these symptoms, call your doctor right away. They could be signs of a serious health condition, such as an infection.

In case of overdose

Symptoms of a Pepto-Bismol overdose can include:

• ringing in your ears
• loss of hearing
• extreme drowsiness
• nervousness
• fast breathing
• confusion
• seizures

If you think you’ve taken too much, call your doctor or local poison control center. If your symptoms are severe, call 911 or local emergency services, or go to the nearest emergency room right away.

For many people, Pepto-Bismol is a safe, easy way to relieve common stomach problems. But if you have any concerns about whether Pepto-Bismol is a safe option for you, be sure to ask your doctor or pharmacist.

Also call your doctor if Pepto-Bismol doesn’t ease your symptoms after 2 days.

Shop for Pepto-Bismol.

Dosage warning

This product should not be used in children younger than 12 years.

Was this helpful?

Bismol – instructions for use, dosages, composition, analogues, side effects / Pillintrip

Page reviewed by pharmacist Oleinik Elizaveta Ivanovna Last update 2020-04-03

Attention!
The information on this page is for healthcare professionals only!
The information is collected from open sources and may contain significant errors!
Be careful and double-check all the information on this page!

Top 20 medicines with the same ingredients: sBismuth CPCKaopectate (Oral)Bitni XPepto-Bismol Extra Strength

Top 20 drugs with the same use:

ReglanPeptolitePink BismuthAkso-DKola-PectinPeoptogastrinSetlers AntacidBismosanKapectolin (Oral)Maalox Total Stomach ReliefBismolDiotameMajor BismatrolMajor Kao-TinPeptic ReliefPep to-Bismol Maximum StrengthExamples include KaopectateKaopectate Extra Strength(ANTASID)Kaopectate suspensionMaalox Total Stomach Relief Liquid

Description Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

Pepto-Bismol chewable tablets, 262.5 mg / tablet

Description Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more. ..

ACTIVE INGREDIENT

Each tablet contains 262.5 mg of bismuth subsalicylate

for excipients see 6.1

Description Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

Chewable tablet

Description Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

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for quick relief of indigestion, indigestion, heartburn and nausea. Controls diarrhea.

Description Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

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Adults and children over 16 years: 2 tablets

If necessary, repeat the dose every 1/2-1 hour. Do not exceed 16 tablets in 24 hours.

One adult dose (2 tablets) contains 525 mg of bismuth subsalicylate

Do not exceed the recommended dose.

Pepto-Bismol can be taken on an empty stomach before or after meals.

for oral use only.

Description Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

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Pepto-Bismol should not be used by people who are hypersensitive to aspirin or other salicylates.

Pepto-Bismol should not be used by people who are hypersensitive to an ingredient in the formulation.

Pepto-Bismol should not be used by children under 16 years of age.

Description Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

more…

Do not take aspirin or other salicylates

Pepto-Bismol should not be used by people under the age of 16 due to a possible association between salicylates and Reye’s syndrome, a very rare but very serious condition.

Caution should be exercised in patients with bleeding disorders or gout, or who are taking medications for blood clotting (blood thinning), diabetes, or gout.

Pepto-Bismol should not be used if symptoms are severe or persist for more than 2 days.

Fluid and electrolyte deficiencies may occur in patients with diarrhea, especially in the frail and elderly. In such cases, the administration of an appropriate fluid and electrolyte replacement therapy is the most important measure.

Do not exceed the recommended dose. Do not use for longer than 2 days except on the advice of a physician. Use at higher than recommended doses or for a longer period of time is associated with an increased risk of side effects (especially mismatch poisoning).

Keep all medicines out of the reach of children.

Description Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

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Nobody.

Side effects

Description Side effects Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

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Gastrointestinal disorders :

Black tongue common (> 1/100, <1/10)

Black stool very common (> 1/10)

Notice of alleged side effects

it is important to report suspected side effects after drug approval. This allows for continuous monitoring of the balance of benefits and risks of the drug. Healthcare professionals are encouraged to report suspected side effects through the Yellow Card system at: www.mhra.gov.uk/yellowcard .

Overdose

Description Overdose Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
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Bismuth

Bismuth toxicity can occur in acute encephalopathy with confusion, myoclonic movements, tremors, dysarthria, and gait and stinging disorders. Bismuth poisoning can also cause gastrointestinal disturbances, skin reactions, mucosal discoloration, and renal dysfunction resulting from acute tubular necrosis. Treatment includes gastric lavage, cleansing and moisturizing. Chelating agents may be effective in the early stages after ingestion, and hemodialysis may be required.

Salicylate

An overdose of Pepto-Bismol can also cause symptoms of salicylate poisoning. Salicylate poisoning is usually associated with plasma concentrations >350 mg/L (2.5 mmol/L). Most adult deaths occur in patients whose concentrations exceed 700 mg/L (95.1 mmol/L). Single doses of less than 100 mg/kg are unlikely to cause serious poisoning.

If symptoms develop, use of Pepto-Bismol should be discontinued. Overdose management is the same as for salicylate overdose:

General characteristics vomiting, dehydration, tinnitus, dizziness, numbness, sweating, warm extremities with restrictive impulses, increased respiratory rate and hyperventilation. Some amount of acid-base disorder is present in most cases.

Mixed respiratory alkalosis and metabolic acidosis with normal or high arterial pH (normal or low concentration of hydrogen ions) is common in adults and children over four years of age. Dominant metabolic acidosis with low arterial pH (increased concentration of hydrogen ions) is common in children over the age of four years. Acidosis can increase the transport of salicylate across the blood-brain barrier.

rare features of include hematemesis, hyperpyrexia, hypoglycemia, hypokalemia, thrombocytopenia, elevated INR/RTP, intravascular coagulation, renal failure, and non-cardiac pulmonary edema.

Features of the central nervous system such as confusion, disorientation, coma and seizures are less common in adults than in children.

Administration: Give activated charcoal if an adult presents within one hour of taking more than 250 mg/kg. Plasma salicylate concentration should be measured, although the severity of poisoning cannot be determined solely by this, and clinical and biochemical characteristics should be taken into account. Elimination is enhanced by alkalinization of the urine, which is achieved by administering 1.26% sodium bicarbonate. Urine pH should be monitored. Correct metabolic acidosis when administered intravenously. 4% sodium bicarbonate (first review of serum potassium). Forced diuresis should not be used as it cannot increase salicylate excretion and cause pulmonary edema.

Hemodialysis is the preferred treatment for severe poisoning and should be considered in patients with plasma salicylate concentrations > 700 mg/l (5.1 mmol/l) or lower concentrations associated with severe clinical or metabolic characteristics. Patients under ten years of age and over 70 years of age are at increased risk of salicylate toxicity and may need dialysis at an earlier stage.

Pharmacodynamics

Description Pharmacodynamics Pepto-Bismol is an automatic translation from the original language.
Do not use this information for any medical prescription or manipulation under any circumstances.
Be sure to read the original instructions for the medicine from the package.
This description may contain numerous errors due to automatic translation!
Keep this in mind and do not use this description!

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Pharmacotherapeutic code: ATC code A07B B

The demulsifying base offers a protective layer in the lower esophagus and a partial layer in the stomach that keeps bismusubsalicylate in suspension.

Limited in vitro studies have shown that BSS has some activity against the enteropathogenic, ie Clostridium. Bacterides, E. coli, Salmonella Shigellen, campoylobacter (Helicobacter) and Yersina, but not against anaerobes. Insufficient data to determine whether these results are relevant to treatment outcomes in the patient population who may receive BSS

Pharmacokinetics

Description Pharmacokinetics Pepto-Bismol is an automatic translation from the original language.
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Bismuth subalicylate is converted to bismuth carbonate and sodium salicylate in the small intestine.

The oral bioavailability of bismuth administered as bismuth subsalicylate is extremely low. Very little is known about the distribution of wisdom in human tissues. Renal clearance is the main route of elimination of absorbed bismuth, but bile clearance may also play a role. The rest is excreted in the feces in the form of insoluble salts of wisdom. Following the maximum recommended daily dose for adults, the mean biological half-life is approximately 33 hours, and peak values ​​for plasma bismuth remain below 35 ppm.

Salicylate is absorbed from the intestine and rapidly distributed to all body tissues. Peak plasma levels after the maximum recommended daily dose are approximately 110 µg/mL. Salicylate is rapidly eliminated from the body and has an average biological half-life of approximately 4-5.5 hours.

Preclinical Safety Data Sheet

Description Preclinical Safety Data Sheet Pepto-Bismol is an automatic translation from the original language.
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no preclinical safety data relevant to healthcare professionals not yet covered elsewhere in SPC

Related Substances

Description Related Substances Pepto-Bismol is an automatic translation from the original language.
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Mannitol

Calcium carbonate

Povidone

Magnesium stearate

Talc

Mint flavor

Saccharin sodium 90 065

Aspartame

Amaranth, aluminum lake (E123)

Vanilla cream flavor

Interaction

Description Interaction Pepto-Bismol is an automatic translation from the original language.
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No one specified.

Expiry date

Description Expiry date Pepto-Bismol is an automatic translation from the original language.
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36 months

Storage

Description Storage Pepto-Bismol is an automatic translation from the original language.
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do not store above 25 ° C

Packaging and content

Description Packaging and content of Pepto-Bismol is an automatic translation from the original language.
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12 or 24 cellophane-wrapped tablets packed in outer clay box

Special precautions for disposal and other handling

Description Special precautions for disposal and other handling Pepto-Bismol is automatic translation from the original language.
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No

Authorization holder and manufacturer

Description Authorization holder and manufacturer Pepto-Bismol is an automatic translation from the original language.
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Procter & Gamble (Health & Beauty Care) Limited

Heights

Brooklands

Weybridge

Surrey

KT13 0XP 90 065

Authorization number

Description Pepto-Bismol authorization number is automatic translation from the original language.
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PL 00129/0143

First approval date

Description First approval date Pepto-Bismol is an automatic translation from the original language.
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15/06/2010

Text revision date

Description Text revision date Pepto-Bismol is an automatic translation from the original language.
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03/31/2016

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Pepto-Bismol: What do you want to know

Introduction

Chances are you’ve heard of “pink things”. “Pepto-Bismol is a widely available over-the-counter medication used to treat digestive problems. If you’re feeling a bit nauseous, read on to find out what to expect while taking Pepto-Bismol and how to use it safely.

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About Pepto-Bismol

What is Pepto-Bismol?

Pepto-Bismol is used to treat diarrhea and relieve symptoms of indigestion. These symptoms may include heartburn, nausea, and indigestion. They may also include gas, belching, and feeling full. The active ingredient in Pepto-Bismol is called bismuth subsalicylate. It belongs to a class of drugs called salicylates. Pepto-Bismol is available in regular quality as a caplet, chewable tablet, and liquid. It is available in maximum strength as a liquid. All forms are taken by mouth.

Action

How does it work?

Pepto-Bismol is supposed to treat diarrhea:

• Increase the amount of fluid your intestines absorb
• , reduces inflammation and hyperactivity of your intestines
• preventing your body from releasing a chemical called prostaglandin that causes inflammation
• blocking toxins produced by bacteria such as E. coli
• kills other bacteria that cause diarrhea

The active ingredient, bismuth subsalicylate, also has antacid properties that can help reduce heartburn, indigestion, and nausea.

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Dosage

Dosage

Dosage Warning This product should not be used in children under 12 years of age.

Adults and children 12 years of age and older may take any of the following forms of Pepto-Bismol for up to two days. The doses below apply for all digestive problems. Pepto-Bismol may help heal. If your condition lasts longer than two days, or if you have ringing in your ears, stop taking Pepto-Bismol and call your doctor.

Liquid Suspension

Regular Strength:

• Take 30 ml (525 mg) every 30-60 minutes as needed.
• Do not exceed eight doses (240 ml) in 24 hours.

Maximum strength:

• Take 30 ml (1.050 mg) every 60 minutes as needed.
• Do not exceed four doses (120 ml) in 24 hours.

Chewable Tablets

• Take two 262 mg tablets every 30-60 minutes as needed.
• Chew or dissolve tablets in mouth.
• Do not exceed eight doses (16 tablets, or 4.192 mg) in a 24 hour period.

Caplets

• If necessary, take two capsules (262 mg each) every 30-60 minutes.
• Swallow the caplets whole with water. Don’t chew them.
• Do not exceed eight doses (16 capsules or 4.192 mg) in a 24 hour period.

Side effects

Side effects

Most side effects from Pepto-Bismol are mild and disappear soon after the medication is stopped.

More common side effects

More common side effects of Pepto-Bismol include:

• black stools
• black hairy tongue

These side effects are harmless. Both effects are temporary and disappear within a few days of stopping Pepto-Bismol.

• Why can Pepto-Bismol give me black stool and black hairy tongue?

• Pepto-bismol contains a substance called bismuth. When this substance mixes with sulfur (a mineral in your body), it forms another substance called bismuth sulfide. This stuff is black. When it is formed in the digestive tract, it mixes with food as you digest it. This causes your stool to turn black. When bismuth sulfide forms in your saliva, it turns your tongue black. It also causes dead skin cells to build up on the surface of your tongue, which can make your tongue look furry.

  – Healthline Medical Team

Serious side effect

Tinnitus is an unusual and serious side effect of Pepto-Bismol. If you have this side effect, stop taking Pepto-Bismol and call your doctor right away.

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Interactions

Drug Interactions

Pepto-Bismol may interact with any other medicines you may be taking. Talk to your pharmacist or doctor to see if Pepto-Bismol interacts with any medications you may be taking.

Definition. An interaction is when a substance changes the way the drug works. This can be harmful or prevent the drug from working.

Examples of drugs that may interact with Pepto-bismol are:

• Angiotensin-converting enzyme (ACE) inhibitors such as benazepril, captopril, enalapril, fosinopril, lisinopril and trandolapril
• Blood thinners (anticoagulants), such as warfarin
• Drugs for diabetes, such as insulin, metformin, sulfonylureas, dipeptidyl peptidase-IV (DPP-IV) inhibitors, and sodium glucose transfer (SGLT) inhibitors 2
• Medicines for gout, such as probenecid
• Methotrexate Other salicylates such as aspirin
• Non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, naproxen, ibuprofen, meloxicam, indomethacin and diclofenac
• Phenytoin
• Tetracycline antibiotics such as demeclocycline, doxycycline, minocycline and tetracycline
• Anti-seizure drugs such as valproic acid and divalprox
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Warnings

Warnings

Pepto Bismol is generally safe for most people, but you should avoid it if you have certain health conditions, Pepto Bismol can make them worse.

You should not take Pepto-Bismol if you:

are allergic to salicylates (including aspirin or NSAIDs such as ibuprofen, naproxen and celecoxib)

• have an active, bleeding ulcer
• passes bloody stools or black stools that are not caused by Pepto-Bismol
• are adolescents who are recovering or ill from chickenpox or flu-like symptoms
• Bismuth subsalicylate can also cause problems in people with other medical conditions. Before taking Pepto-Bismol, tell your doctor if you have any of the following medical conditions. They can tell you if you can use Pepto-Bismol. These terms include:

stomach ulcers

• bleeding problems such as hemophilia and von Willebrand disease
• kidney problems
• diabetes
• Stop taking Pepto-Bismol and call your doctor at once if you have vomiting and extreme diarrhea, or behavioral changes such as loss of energy, aggressive behavior, or confusion. These symptoms may be early symptoms of Reye’s syndrome. This is a rare but serious illness that can affect your brain and liver.
• Continue Reading: Causes, Symptoms, and Diagnosis of Reye’s Syndrome »

You should not use Pepto-Bismol to self-medicate diarrhea if you have a fever or stools containing blood or mucus. If you have these symptoms, call your doctor right away. They may be signs of a serious health condition, such as an infection.

Overdose

Symptoms of Pepto-Bismol overdose may include:

Talk to your doctor

For many people, Pepto-Bismol is a safe and easy way to get rid of common stomach problems. But if you have any doubts about whether Pepto-Bismol is a safe option for you, be sure to ask your doctor or pharmacist.