Phenoxybenzamine for Dogs and Cats

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General Drug Information and Indications

Phenoxybenzamine is used in dogs and cats that have difficulty urinating due to spasms in the urethra. It is also used to reduce blood pressure in animals with a certain type of tumor called pheochromocytoma. This rare tumor of the adrenal gland most commonly occurs in older dogs, but may also occur in cats. Phenoxybenzamine is used in horses to decrease urethral sphincter tone, and there are some experimental reports on its use in the early stages of laminitis and for some types of diarrhea.

Like many other drugs in veterinary medicine, this drug is not FDA approved for use in animals and is not available from a veterinary pharmaceutical manufacturer. Instead, it is compounded by a specialty pharmacy.

How to Give this Medication

Give this medication to your pet exactly as your veterinarian prescribes. If you miss giving your pet a dose of phenoxybenzamine, give the next dose as soon as you remember, or, if it is close to the next scheduled dose, return to the regular schedule. Do not double dose in order to catch up.

Give with food to reduce GI (stomach) upset.

Wash your hands after giving your pet this medication.

Side Effects

Be sure to discuss any side effects with your veterinarian immediately.

Phenoxybenzamine can cause changes in blood pressure, most often low blood pressure. Other side effects include rapid heart beat, weakness, dizziness, nasal congestion, pinpoint pupils, inability to ejaculate, nausea, and vomiting.

Phenoxybenzamine can cause constipation and colic in horses.

Precautions

Keep this and all drugs out of reach of children. Phenoxybenzamine is a prescription drug and should be used according to your veterinarian’s directions. It should only be given to the animal for which it was prescribed. Do not give this medication to a person.

Phenoxybenzamine should be avoided in animals that are in shock, dehydrated, or have decreased kidney function. Your veterinarian may choose to use intravenous fluids to support your pet under these circumstances.

Phenoxybenzamine should be used with caution in animals with congestive heart failure or other heart problems.

Phenoxybenzamine should not be used in animals with glaucoma or diabetes mellitus.

Phenoxybenzamine should not be used in horses with signs of colic.

Drug Interactions

Be sure to review with your veterinarian any medications or supplements your pet may be receiving.

The following drugs may interact with phenoxybenzamine: epinephrine, phenylephrine, and reserpine.

Overdose

If you suspect your pet or another animal was overdosed accidentally or has eaten this medication inadvertently, contact your veterinarian or the A.S.P.C.A.’s Animal Poison Control Center at 888.426.4435. Always bring the prescription container with you when you take your pet for treatment.

If you or someone else has accidentally ingested this medication call the National Capital Poison Center at 800.222.1222.

Storage

Different strengths or dosage forms of phenoxybenzamine may have different storage requirements. Read the labeling or ask your pharmacist for the storage requirements of the prescription you receive.

About the Author

Dr. Barbara Forney is a veterinary practitioner in Chester County, Pennsylvania. She has a master’s degree in animal science from the University of Delaware and graduated from the University of Pennsylvania School of Veterinary Medicine in 1982.

She began to develop her interest in client education and medical writing in 1997. Recent publications include portions of The Pill Book Guide to Medication for Your Dog and Cat, and most recently Understanding Equine Medications published by the Bloodhorse.

Dr. Forney is an FEI veterinarian and an active member of the AAEP, AVMA, and AMWA.

Dibenzyline (phenoxybenzamine) dosing, indications, interactions, adverse effects, and more

Phenoxybenzamine capsules

What is this medicine?

PHENOXYBENZAMINE (fen ox ee BEN za meen) is used to treat high blood pressure and sweating associated with pheochromocytoma.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): Dibenzyline

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:

• heart or circulation disease
• kidney disease
• shock
• stroke
• an unusual or allergic reaction to phenoxybenzamine, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

• epinephrine
• medicines for colds and breathing difficulties
• medicines for high blood pressure
• medicines used to treat erectile dysfunction (ED) like sildenafil, tadalafil, and vardenafil
• other alpha-blockers like alfuzosin, doxazosin, phentolamine, prazosin, tamsulosin, terazosin
• reserpine

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress.

Drowsiness and dizziness are more likely to occur after the first dose, after an increase in dose, or during hot weather or exercise. These effects can decrease once your body adjusts to this medicine. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
• confusion
• dizziness or drowsiness
• feeling faint or lightheaded
• fast or irregular heartbeat, palpitations or chest pain
• unusually weak or tired
• vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• headache
• nasal stuffiness
• nausea
• sexual difficulties for men

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Phenoxybenzamine Hydrochloride | Healthgrades | (capsule)

Brand Name: Phenoxybenzamine Hydrochloride

Generic Name: PHENOXYBENZAMINE HYDROCHLORIDE

Drug Type: HUMAN PRESCRIPTION DRUG

Route: ORAL

Dosage Form: CAPSULE

Data Current As Of: 2018-10-11

Rx only

Phenoxybenzamine hydrochloride capsules are indicated in the treatment of pheochromocytoma, to control episodes of hypertension and sweating. If tachycardia is excessive, it may be necessary to use a beta-blocking agent concomitantly.

Conditions where a fall in blood pressure may be undesirable; hypersensitivity to the drug or any of its components.

The following adverse reactions have been observed, but there are insufficient data to support an estimate of their frequency.

Autonomic Nervous System*: Postural hypotension, tachycardia, inhibition of ejaculation, nasal congestion, miosis.

*These so-called “side effects” are actually evidence of adrenergic blockade and vary according to the degree of blockade.

Miscellaneous: Gastrointestinal irritation, drowsiness, fatigue.

SYMPTOMS – These are largely the result of blocking of the sympathetic nervous system and of the circulating epinephrine. They may include postural hypotension, resulting in dizziness or fainting; tachycardia, particularly postural; vomiting; lethargy; shock.

The dosage should be adjusted to fit the needs of each patient. Small initial doses should be slowly increased until the desired effect is obtained or the side effects from blockade become troublesome. After each increase, the patient should be observed on that level before instituting another increase. The dosage should be carried to a point where symptomatic relief and/or objective improvement are obtained, but not so high that the side effects from blockade become troublesome.

Initially, 10 mg of phenoxybenzamine hydrochloride twice a day. Dosage should be increased every other day, usually to 20 to 40 mg 2 or 3 times a day, until an optimal dosage is obtained, as judged by blood pressure control.

Long-term use of phenoxybenzamine is not recommended (see PRECAUTIONS: Carcinogenesis and Mutagenesis). 

Phenoxybenzamine Hydrochloride Capsules USP

10 mg capsules is supplied as a red opaque/red opaque capsule with “54 036” printed in black on the cap and “54 036” printed in black ink on the capsule body, containing a white to off-white powder.

NDC 0054-0349-25: Bottle of 100 Capsules

Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]

PHENOXYBENZAMINE

Phenoxybenzamine (By mouth) | Drug Notes | Health Information

Phenoxybenzamine (By mouth)

Phenoxybenzamine (fen-ox-ee-BEN-za-meen)

Treats high blood pressure and sweating caused by pheochromocytoma.

Brand Name(s):

Dibenzyline

There may be other brand names for this medicine.

When This Medicine Should Not Be Used:

This medicine is not right for everyone. Do not use it if you had an allergic reaction to phenoxybenzamine, or if you have a condition that could be worsened by very low blood pressure.

How to Use This Medicine:

Capsule

• Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
• Missed dose:
  Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

Drugs and Foods to Avoid:

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Some medicines can affect how phenoxybenzamine works. Tell your doctor if you are using diet pills or medicine to treat colds, hay fever, or a stuffy nose.

Warnings While Using This Medicine:

• Tell your doctor if you are pregnant or breastfeeding, or if you have heart disease, chest pain (angina), blood vessel disease, a lung infection, or kidney disease.
• This medicine may make you dizzy or drowsy. Do not drive, use machines, or do anything else that may be dangerous until you know how this medicine affects you.
• Dizziness may be worse when you stand up quickly. It may help to rise slowly from a sitting or lying position.
• This medicine is not for long-term use.
• Keep all medicine out of the reach of children. Never share your medicine with anyone.

Possible Side Effects While Using This Medicine:

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Fainting
• Fast heartbeat

If you notice these less serious side effects, talk with your doctor:

• Blurred vision
• Nausea or vomiting
• Stuffy nose
• Tiredness or drowsiness
• Trouble with ejaculation

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Last Updated: 1/27/2017

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only — they do not constitute endorsements of those other sites.

Truven Health Analytics. All rights reserved.

Phenoxybenzamine 10mg for Lowering the Blood Pressure – Order @ $2.72 per Tablet

What is Phenoxybenzamine used for?

Phenoxybenzamine is used to treat high blood pressure and sweating caused by a disease called pheochromocytoma (a type of tumor of the adrenal glands). Phenoxybenzamine belongs to a class of medications known as alpha blockers. It works by relaxing and widening blood vessels, which lets the blood to flow more easily, thereby lowering the high blood pressure.

This medicine may also be used to treat other conditions as determined by your doctor.

What is the recommended dosage of Phenoxybenzamine?

The dosage of Phenoxybenzamine prescribed to each patient will vary. Always follow your physician’s instructions and/or the directions on the prescription drug label.

Phenoxybenzamine can be taken with or without food. Take Phenoxybenzamine by mouth with a full glass of water.

What if you miss a dose of Phenoxybenzamine?

If your physician has instructed or directed you to take Phenoxybenzamine medication in a regular schedule and you have missed a dose of this medicine, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and go back to your regular dosing schedule. Do not double the doses unless otherwise directed.

What if you overdose on Phenoxybenzamine?

Any medication taken in excess can have serious consequences. If you suspect an overdose of Phenoxybenzamine, seek medical attention immediately. Overdose symptoms of Phenoxybenzamine may include fainting, fast heart rate, severe weakness and dizziness.

It may be noted that drugs other than those listed above may also interact with Phenoxybenzamine.

Usually drug interactions occur when it is taken with another drug or with food. Before you take a medication for a particular ailment, you should inform the health expert about intake of any other medications including non-prescription medications (over-the-counter products) and dietary supplements like vitamins, minerals and herbal, which may increase the effect of Phenoxybenzamine, so that the doctor can warn you of any possible drug interactions.

Phenoxybenzamine can interact with other high blood pressure medications, erectile dysfunction medications, muscle relaxants, antiseizure drugs and psychiatric medicines.

Do let your doctor know if you smoke, consume alcohol or caffeinated drinks, or use illegal drugs as these may interfere with the action of your medication. Make sure to inform your doctor of any medical conditions you may have, or any family history of medical problems. Do not start or stop using any medicine without consulting your doctor.

What are the side effects of Phenoxybenzamine?

Like other medicines, Phenoxybenzamine can cause some side effects. If they do occur, the side effects of Phenoxybenzamine are most likely to be minor and temporary. However, some may be serious and may require the individual to inform the doctor or visit the nearest hospital immediately.

It is pertinent to note that side effects of Phenoxybenzamine cannot be anticipated. If any side effects of Phenoxybenzamine develop or change in intensity, the doctor should be informed as soon as possible.

Phenoxybenzamine can cause side effects such as dizziness, tiredness, drowsiness, stuffy nose, stomach upset and sexual dysfunction. This is not a complete list of all side effects. Do concur with your doctor and follow his directions completely when you are taking Phenoxybenzamine.

What are the questions to ask your doctor before taking Phenoxybenzamine?

Is it possible for me to take Phenoxybenzamine with other drugs?

Should certain beverages, foods and other products be avoided when I take Phenoxybenzamine?

What are the possible drug interactions of Phenoxybenzamine?

How will Phenoxybenzamine work in my body?

How should Phenoxybenzamine be taken?

How to reduce the risk of Phenoxybenzamine drug interactions and side effects?

Note

The health and medical information provided here is intended to supplement and not substitute for the expertise and judgment of your physician, pharmacists or other health care professional. It should not be understood to indicate that the use of Phenoxybenzamine is safe, appropriate or effective for you. Always consult your health care professional before using this, or any other, drug.

Before taking Phenoxybenzamine, inform your doctor if you are pregnant, planning to become pregnant, or are breast-feeding. Also tell your doctor if you have kidney problems, heart problems, blood vessel disease and a lung or respiratory tract infection. Before having dental surgery, tell the dentist that you are using Phenoxybenzamine.

Phenoxybenzamine

What is phenoxybenzamine?

Phenoxybenzamine is one of the drugs known as alpha blockers.This drug is used to treat high blood pressure or a related serious condition called pheochromocytoma. It is also widely used in the treatment of a range of bladder problems. This drug has many side effects and is not recommended for patients with heart disease or for pregnant or nursing mothers.

As an alpha blocker, phenoxybenzamine lowers blood pressure, especially when it is caused by a pheochromocytoma. High blood pressure occurs when the force to pump blood through the blood vessels becomes too great.Blood vessels become narrowed, partially clogged, or lose elasticity. It is most often caused by various diseases or poor lifestyle choices.

Pheochromocytoma – tumor growth of the adrenal glands. Growth disrupts the complex function of the glands. One of the many consequences of this disease is the production of too much of a chemical that causes the blood vessels to constrict significantly, thereby raising blood pressure to potentially dangerous levels.This chemical attaches to alpha receptors located on the wall of blood vessels and instructs them to contract. Phenoxybenzamine blocks the chemical and prevents it from attaching to alpha receptors, which inhibits the narrowing of blood vessels and helps maintain adequate blood pressure.

Disruption of pheochromocytoma also causes heavy sweating, which is potentially very severe. Constant excessive sweating can cause dehydration and dangerous salt and electrolyte imbalances as water, salt and minerals are quickly depleted from the body.Phenoxybenzamine works to reduce sweat production to help the body maintain homeostasis. This medication may also help reduce overactive bladder syndrome and urinary incontinence.

Phenoxybenzamine side effects may include dizziness and blurred vision. Patients are advised not to drive or operate a car while the medication is in the system and any side effects that the patient may experience have been identified. Tachycardia, low blood pressure, and sexual dysfunction in men are also common side effects of this drug.

Phenoxybenzamine should not be taken with narcotic pain relievers, seizure medications, or other blood pressure medications, including alpha and beta blockers. Also not recommended for patients with pre-existing heart disease. This drug is rarely given to pregnant or nursing mothers. If used during pregnancy, a baby could have dangerously low blood pressure, tachycardia, or developmental problems. In nursing mothers, the drug may be present in breast milk and therefore can be easily passed on to the infant.

OTHER LANGUAGES

Controversies in the management of feline urethral obstruction – Part 3.

Urethral relaxants / antispasmodics

Given the potential role of urethral spasm and increased smooth muscle tone in the pathogenesis of obstruction or re-obstruction, the use of urethral relaxants / antispasmodics is becoming relatively common in the treatment of urethral obstruction, especially in the post-obstructive period. This approach is supported by reports of up to 53% of “idiopathic obstruction”, that is, without an obvious source of physical obstruction (and suggesting more functional obstruction) [4]

In addition, data from a previously described study [18] showing a treatment protocol for urethral obstruction without catheterization suggests that spontaneous urination can be achieved by a combination of factors, including analgesia and urethral relaxation.This suggests a functional component of the obstructive process, although no direct assessment of the pharmacological effects of drugs has been done.

Drugs commonly used to relax the urethra include phenoxybenzamine, acepromazine, and prazosin, which are α-1 antagonists that induce smooth muscle relaxation. Although phenoxybenzamine has been shown to reduce preprostatic urethral pressure, it appears to be less effective than other drugs.[32, 33] In addition, the pharmacological effects of phenoxybenzamine can be delayed up to a week, thereby making it potentially less useful in the treatment of obstructive emergencies. Acepromazine has also been shown to induce significant reductions in preprostatic and optionally prostatic intraurethral pressures, but does not have any discernible effect on postprostatic urethra or penile urethra in anesthetized male cats. [32] Acepromazine also induces sedation and thereby reduces stress stress. response by decreasing the activity of dopamine in the central nervous system.Given the potential role of excessive sympathetic activation in cats with idiopathic cystitis [7], it may have an additional benefit in the treatment of these patients.

Prazosin has become the selective α-1 antagonist of choice for inducing urethral relaxation due to its faster onset of action compared to phenoxybenzamine and the lack of sedative effects of acepromazine (if sedation is undesirable). The ability of prazosin to lower urethral pressure has been demonstrated in several studies in cats, although, similar to acepromazine, it appears to only affect the preprostatic and prostatic urethra.[34-37] One of these studies also demonstrated a decrease in central sympathetic output as well as direct α-1 antagonism of urethral smooth muscle.

A recent retrospective study of the factors influencing obstruction re-obstruction found that patients treated with prazosin had significantly lower recurrence rates, both after 24 hours (7% versus 22%) and after 30 days (18% versus 39%). when compared with phenoxybenzamine. [22] However, as previously mentioned, there is some methodological disagreement regarding this study, which suggests that further research is needed to confirm these results.

Importantly, despite their frequent use, there is little evidence to support the benefit of urethral relaxants in the management of feline urethral obstruction. As mentioned in a recent study by Hetrick et al, only the proximal 1 / 4-1 / 3 of the feline urethra consists of smooth muscle, with the remainder having skeletal muscle [38]. As such, α-1 antagonists will have minimal effect on the distal ( especially the urethra of the penis) the urethra, where most obstructions are thought to be observed, as supported by previously mentioned studies [34–37].

Further, there is limited evidence for significant urethral spasm or increased urethral pressures in feline urethral obstruction. In fact, one study found normal to reduced urethral pressures, although it was conducted in a small group of animals (6 cats) and patients were anesthetized (which may affect urethral tone) [39] a role in the occurrence of re-obstruction due to urethral irritation and inflammation after catheterization.

However, a double-blind, placebo-controlled prospective study failed to show differences in recurrence rates in cats with urethral obstruction who received or did not receive prazosin for 1 month after the obstruction. [40] It is important to note that this study had a relatively low number of animals (20 in the prazosin group and 16 in the control group) and, in general, a significantly lower incidence of recurrence (5-8%), compared to other studies (see below). which could make it very difficult to identify the differences.

Despite the widespread use of urethral relaxants based on unverified information and the ability to reduce pressure in the proximal urethra, given the potentially conflicting information regarding the pathophysiology of the pathological process and limited clinical evidence, further research is needed to determine whether the use of urethral relaxants in post-obstructive treatment of urethral obstruction is warranted cats.

Memorial Sloan Kettering Cancer Center

This document, provided by Lexicomp ^® , contains all the information you need to know about the drug, including the indications, route of administration, side effects and when you should contact your healthcare provider.

Trade names: USA

Dibenzyline

What is this drug used for?

• This medication is used to treat pheochromocytoma.

What do I need to tell my doctor BEFORE taking this drug?

• If you are allergic to this drug, any of its ingredients, other drugs, foods or substances. Tell your doctor about your allergy and how it manifested itself.

The combination of this drug with certain medications and medical conditions may be adverse.

Tell your doctor and pharmacist about all the medicines you take (both prescription and over-the-counter, natural products and vitamins) and your health problems. You need to make sure that this drug is safe for your medical conditions and in combination with other drugs you are already taking. Do not start or stop taking any drug or change the dosage without your doctor’s approval.

What do I need to know or do while taking this drug?

• Tell all healthcare providers that you are taking this drug. These are doctors, nurses, pharmacists and dentists.
• Avoid driving or other activities that require increased attention until you see how this drug affects you.
• To reduce the risk of dizziness or loss of consciousness, get up slowly from a lying or sitting position.Use caution when going up and down stairs.
• Measure blood pressure and heart rate as directed by your doctor.
• Do not take this drug for longer than your doctor prescribed.
• Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. The benefits and risks for you and your child will need to be discussed.

What side effects should I report to my doctor immediately?

WARNING. In rare cases, some people with this drug can cause serious and sometimes deadly side effects. Call your doctor or get medical attention right away if you have any of the following signs or symptoms, which may be associated with serious side effects:

• Signs of an allergic reaction, such as rash, hives, itching, reddened and swollen skin with blisters or scaling, possibly associated with fever, wheezing or wheezing, tightness in the chest or throat, difficulty breathing, swallowing or speaking, unusual hoarseness, swelling in the mouth, face, lips, tongue, or throat.
• Severe dizziness or fainting.
• Rapid heartbeat.
• Constricted pupils.
• Ejaculation disorders.

What are some other side effects of this drug?

Any medicine can have side effects. However, many people have little or no side effects. Call your doctor or get medical help if these or any other side effects bother you or do not go away:

• Sleepiness.
• stuffy nose.
• Nausea.
• Feeling tired or weak.

This list of potential side effects is not exhaustive. If you have any questions about side effects, please contact your doctor. Talk to your doctor about side effects.

You can report side effects to the National Health Office.

You can report side effects to the FDA at 1-800-332-1088.You can also report side effects at https://www.fda.gov/medwatch.

What is the best way to take this drug?

Use this drug as directed by your healthcare practitioner. Read all the information provided to you. Follow all instructions strictly.

• Take this drug with or without food.

What to do if a dose of a drug is missed?

• Take the missed dose as soon as you can.
• If it’s time to take your next dose, do not take the missed dose and then return to your normal dose schedule.
• Do not take 2 doses at the same time or an additional dose.

How do I store and / or discard this drug?

• Store at room temperature in a dry place. Do not store in the bathroom.
• Store all medicines in a safe place. Keep all medicines out of the reach of children and pets.
• Dispose of unused or expired drugs. Do not empty into toilet or drain unless directed to do so. If you have any questions about the disposal of your medicinal products, consult your pharmacist. Your area may have drug recycling programs.

General information on medicinal products

• If your health does not improve or even worsens, see your doctor.
• You should not give your medicine to anyone and take other people’s medicines.
• Some medicines may come with other patient information sheets. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
• Some medicines may come with other patient information sheets. Check with your pharmacist. If you have questions about this drug, talk with your doctor, nurse, pharmacist, or other healthcare professional.
• If you think there has been an overdose of a drug, call a Poison Control Center immediately or seek medical attention. Be prepared to tell or show which drug you took, how much and when it happened.

Consumer Use and Limitation of Liability

This information should not be used to make decisions about taking this or any other drug. Only the attending physician has the necessary knowledge and experience to make decisions about which drugs are appropriate for a particular patient.This information does not guarantee that the drug is safe, effective, or approved for the treatment of any disease or specific patient. Here are only brief general information about this drug. It does NOT contain all available information on the possible use of the drug with instructions for use, warnings, precautions, information about interactions, side effects and risks that may be associated with this drug. This information should not be construed as a treatment guide and does not replace information provided to you by your healthcare professional.Check with your doctor for complete information on the possible risks and benefits of taking this drug. Use of this information is governed by the Lexicomp End User License Agreement available at https://www.wolterskluwer.com/en/solutions/lexicomp/about/eula.

Copyright

© UpToDate, Inc. and its affiliates and / or licensors, 2021. All rights reserved.

instructions for use, dosage, composition, analogs, side effects / Pillintrip

Special warnings and precautions

WARNINGS

Dibenziran (phenoxybenzamine) -induced alpha -adrenergic blockade goes away beta -adrenergic receptors.Compounds that stimulate both types of receptors can therefore cause an exaggerated hypotensive response and tachycardia.

PRECAUTIONS

General use with caution in patients with severe cerebral or coronary arteriosclerosis or renal damage. The adrenergic blocking effect can aggravate the symptoms of respiratory infections.

Carcinogenesis and Mutagenesis

Cases of carcinoma have been reported in humans after long-term treatment with phenoxybenzamine.Therefore, long-term use of phenoxybenzamine is not recommended. ^{3, 4} Carefully weigh the benefits and risks before prescribing this drug.

Phenoxybenzamine hydrochloride showed in vitro mutagenic activity in the Ames test and mouse lymphoma assay; this showed no mutagenic activity of in vivo in the micronucleus test in mice. In rats and mice, repeated intraperitoneal administration of phenoxybenzamine hydrochloride (three times a week for up to 52 weeks) resulted in peritoneal sarcomas.Chronic oral administration to rats (up to 2 years old) caused malignant tumors of the small intestine and nonglandular stomach, as well as ulcerative and / or erosive gastritis of the glandular stomach. Considering that squamous cell carcinoma of the nonglandular stomach was observed in all doses of phenoxybenzamine hydrochloride tested, the level of tumors (carcinomas and sarcomas) of the small intestine was not observed. This dose, based on body surface area, is approximately double the maximum recommended human dose of 20 mg twice daily.

Pregnancy – Teratogenic Effects – Pregnancy Category C

Adequate reproductive studies in animals have not been performed with dibenziran (phenoxybenzamine hydrochloride). It is also unknown whether dibenziran (phenoxybenzamine) can harm the fetus when given to a pregnant woman. Dibenziran (phenoxybenzamine) should be given to a pregnant woman only when needed.

Nursing

It is not known whether this drug is excreted in breast milk.Because many medicines are excreted in breast milk and because of the potential for serious adverse reactions from phenoxybenzamine hydrochloride, a decision should be made whether to discontinue breastfeeding or to stop taking the drug, taking into account the importance of the drug to the mother.

Pediatric Use

Safety and efficacy in pediatric patients have not been established.

REFERENCES

3. Nettesheim O, Hoffken G., Gar M., Breidert M .: Hematemesis and dysphagia in a 20-year-old woman with congenital malformation of the spine and situs inversus partmentis [German]. Zeitschrift fur Gastroenterologie. 2003; 41 (4): 319-24.

4. Vaidyanathan S., Mansour P., Sony BM, Hughes PL, Singh G.: Chronic lymphocytic leukemia, synchronous small cell carcinoma and squamous cell neoplasia of the bladder in a paraplegic person after long-term phenoxybenzamine therapy. Spinal cord. 2006; 44 (3): 188-91.

(PDF) Side effects of prostatoprotectors

There are also reports of such side effects of finasteride:

decreased ejaculate volume, abnormal ejaculation, gynecomastia, impotence,

decreased libido 15, 31, 33, 34, 35.Despite the fact that such side effects

occur in a small number of patients (3-7%) and may even disappear

while continuing to take finasteride, the doctor must necessarily tell the patient about them

before treatment.

Pushkar D.Yu et al. (2002) indicate that the most significant

side effects of the drug include: impotence – 3.7%, decreased libido

– 3.3%, decrease in ejaculate volume – 2.8%.According to the observations of

data of the authors, after 4 years of continuous use of finasteride, complaints about

sexual dysfunctions became more rare, and the above complications

accounted for 2.1%; 1.5% and 0.3%, respectively 5.

Plants are historically the first and most ancient source of

biologically active substances. Herbal preparations

are better tolerated, contain natural compounds to which

are evolutionarily adapted, have high bioavailability

and the breadth of therapeutic action, and also cause

the minimum number of side effects.

Sago palm, African plum, African potato,

pumpkin, black poplar, echinacea, nettle and other plants are most often used for the preparation of herbal remedies for the treatment of BPH. Moreover, the first

two plants are the basis for the production of the overwhelming majority of

preparations [36, 37].

In terms of effectiveness, preparations of the sago palm (Serenoa Repens)

are comparable to finasteride, however, they give significantly less side effects

[38], and especially such as impotence and decreased libido, which

are inherent in finasteride.

Studies comparing the safety of sago palm preparations with

other drugs, such as finasteride or tamsulosin,

found that the incidence of side effects did not differ between the groups for

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