Prescription metoprolol. Metoprolol Interactions: Comprehensive Guide to Drug, Disease, and Food Interactions
What are the major drug interactions with metoprolol. How many disease interactions does metoprolol have. What are the alcohol and food interactions with metoprolol. How is metoprolol classified and what are its uses.
Overview of Metoprolol and Its Interactions
Metoprolol is a widely prescribed medication that belongs to the class of drugs known as cardioselective beta blockers. It’s used to treat various cardiovascular conditions, including angina, atrial fibrillation, and hypertension. However, like many medications, metoprolol can interact with other substances and conditions, potentially affecting its efficacy or causing adverse effects.
This comprehensive guide explores the various interactions associated with metoprolol, including drug-drug interactions, disease interactions, and alcohol/food interactions. Understanding these interactions is crucial for healthcare providers and patients to ensure safe and effective use of the medication.
Drug Interactions with Metoprolol: A Detailed Breakdown
Metoprolol is known to interact with a significant number of other medications. In total, there are 503 drugs that have been identified as having potential interactions with metoprolol. These interactions are categorized based on their severity:
- 26 major interactions
- 440 moderate interactions
- 37 minor interactions
The sheer number of potential interactions underscores the importance of a thorough medication review when prescribing or taking metoprolol.
Major Drug Interactions
Major drug interactions are those considered highly clinically significant. These interactions should typically be avoided, as the risks often outweigh the benefits. Some examples of drugs that have major interactions with metoprolol include:
- Certain antiarrhythmic medications
- Some calcium channel blockers
- Specific antidepressants
Healthcare providers should carefully evaluate the necessity of combining these medications with metoprolol and consider alternative treatments when possible.
Moderate Drug Interactions
The majority of metoprolol’s drug interactions fall into the moderate category. While these interactions are less severe than major interactions, they still require careful consideration and potential adjustments to treatment plans. Examples of drugs with moderate interactions include:
- Aspirin
- Certain antidiabetic medications
- Some antihypertensive drugs
In many cases, these combinations can still be used, but dosage adjustments or close monitoring may be necessary.
Minor Drug Interactions
Minor interactions with metoprolol are generally of minimal clinical significance. However, they should still be considered, especially in patients with multiple medications or complex medical histories. Examples include interactions with:
- Certain vitamins and supplements
- Some over-the-counter medications
While these interactions may not require significant intervention, patients should still be aware of them and report any unusual symptoms to their healthcare provider.
Disease Interactions: Metoprolol’s Impact on Various Health Conditions
Metoprolol has been identified to have 19 disease interactions. These interactions highlight conditions where the use of metoprolol may need to be carefully considered or potentially avoided. The list includes:
- Bradyarrhythmia/AV block
- Cardiogenic shock/hypotension
- Congestive heart failure (CHF)
- Diabetes
- Hemodialysis
- Hypersensitivity
- Ischemic heart disease
- Peripheral vascular disease (PVD)
- Liver disease
- Cerebrovascular insufficiency
- Glaucoma
- Hyperlipidemia
- Hyperthyroidism
- Hyperthyroidism pharmacokinetics
- Myasthenia gravis
- Pheochromocytoma
- Psoriasis
- Tachycardia
- Asthma/COPD
These disease interactions emphasize the need for a thorough medical history and ongoing monitoring when prescribing metoprolol.
Cardiovascular Conditions
Given that metoprolol is primarily used to treat cardiovascular conditions, it’s not surprising that many of its disease interactions are related to heart health. For instance, in patients with bradyarrhythmia or AV block, metoprolol could potentially worsen the condition due to its heart rate-lowering effects. Similarly, in cases of cardiogenic shock or severe hypotension, metoprolol’s blood pressure-lowering action could be dangerous.
Metabolic and Endocrine Disorders
Metoprolol can interact with metabolic conditions like diabetes and hyperthyroidism. In diabetic patients, it may mask some of the symptoms of hypoglycemia, making blood sugar management more challenging. For those with hyperthyroidism, metoprolol can affect the condition’s pharmacokinetics and potentially complicate treatment.
Respiratory Conditions
The interaction between metoprolol and respiratory conditions like asthma or COPD is particularly noteworthy. Beta-blockers, even those that are cardioselective like metoprolol, can potentially cause bronchospasm in susceptible individuals. This interaction requires careful consideration and monitoring, especially in patients with a history of reactive airway disease.
Alcohol and Food Interactions with Metoprolol
In addition to drug and disease interactions, metoprolol also has 4 known alcohol/food interactions. Understanding these interactions is crucial for patients to ensure they’re using the medication safely and effectively.
Alcohol Interaction
Alcohol can interact with metoprolol in several ways. It may enhance the blood pressure-lowering effect of the medication, potentially leading to excessive hypotension. Additionally, alcohol can increase the risk of certain side effects associated with metoprolol, such as dizziness and drowsiness.
Patients taking metoprolol should be advised to limit their alcohol consumption and to be aware of how their body responds to the combination. In some cases, it may be recommended to avoid alcohol altogether while on this medication.
Food Interactions
While specific food interactions with metoprolol are less common than drug interactions, there are still some considerations:
- High-fat meals: These can potentially increase the absorption of metoprolol, leading to higher blood levels of the drug.
- Grapefruit and grapefruit juice: While not as significant as with some other medications, grapefruit products can potentially increase the blood levels of metoprolol.
- Salt substitutes: These often contain potassium, which can interact with metoprolol and other blood pressure medications.
Patients should be advised to maintain a consistent diet while taking metoprolol and to inform their healthcare provider of any significant changes in their eating habits.
Understanding Metoprolol’s Classification and Uses
Metoprolol belongs to a class of medications known as cardioselective beta blockers. This classification provides important insights into how the drug works and what conditions it’s used to treat.
What are Cardioselective Beta Blockers?
Cardioselective beta blockers primarily target beta-1 receptors, which are predominantly found in the heart. This selectivity means that at lower doses, metoprolol has less effect on beta-2 receptors found in the lungs and blood vessels, potentially reducing some side effects associated with non-selective beta blockers.
Primary Uses of Metoprolol
Metoprolol is prescribed for various cardiovascular conditions, including:
- Hypertension (high blood pressure)
- Angina pectoris (chest pain due to reduced blood flow to the heart)
- Heart attack (myocardial infarction) treatment and prevention
- Heart failure
- Atrial fibrillation (irregular heartbeat)
In some cases, metoprolol may also be prescribed for off-label uses, such as migraine prevention or treatment of certain types of tremors.
Metoprolol Formulations and Dosage Forms
Metoprolol is available in various formulations and dosage forms, allowing for tailored treatment based on individual patient needs and conditions. Understanding these different forms is crucial for healthcare providers in prescribing and for patients in ensuring proper use of the medication.
Immediate-Release vs. Extended-Release
Metoprolol is available in both immediate-release and extended-release formulations:
- Immediate-release tablets: These are typically taken two to three times daily.
- Extended-release tablets (Metoprolol Succinate): These are usually taken once daily and provide a more consistent blood level of the medication over 24 hours.
The choice between these formulations often depends on the specific condition being treated, patient preference, and adherence considerations.
Dosage Strengths
Metoprolol tablets come in various strengths to allow for precise dosing. Common strengths include:
- 25 mg
- 50 mg
- 100 mg
For extended-release formulations, additional strengths such as 200 mg may be available. The appropriate dosage is determined by the healthcare provider based on the patient’s condition, response to treatment, and other factors.
Monitoring and Managing Metoprolol Interactions
Given the extensive list of potential interactions associated with metoprolol, proper monitoring and management are crucial for ensuring safe and effective treatment. Healthcare providers and patients both play important roles in this process.
Role of Healthcare Providers
Healthcare providers should:
- Conduct thorough medication reviews before prescribing metoprolol
- Consider potential disease interactions based on the patient’s medical history
- Educate patients about possible food and alcohol interactions
- Monitor patients regularly, especially when starting treatment or adjusting dosages
- Be alert for signs of adverse effects or reduced efficacy that could indicate an interaction
Patient Responsibilities
Patients taking metoprolol should:
- Inform all healthcare providers about their metoprolol use
- Avoid starting new medications, including over-the-counter drugs and supplements, without consulting their healthcare provider
- Be aware of potential food and alcohol interactions
- Report any unusual symptoms or side effects promptly
- Adhere to prescribed dosing schedules and any dietary recommendations
By working together, healthcare providers and patients can effectively manage potential interactions and ensure the safe and beneficial use of metoprolol.
Metoprolol Interactions Checker – Drugs.com
Save
There are 503 drugs known to interact with
metoprolol, along with
19 disease interactions, and 4 alcohol/food interactions.
Of the total drug interactions,
26 are major, 440 are moderate, and 37 are minor.
Does metoprolol interact with my other drugs?
Enter other medications to view a detailed report.
- View all 503 medications that may interact with metoprolol
- View metoprolol alcohol/food interactions (4)
- View metoprolol disease interactions (19)
Most frequently checked interactions
View interaction reports for metoprolol and the medicines listed below.
- Major
- Moderate
- Minor
- Unknown
- Advair Diskus (fluticasone / salmeterol)
- Aspir 81 (aspirin)
- Aspirin Low Strength (aspirin)
- Benadryl (diphenhydramine)
- CoQ10 (ubiquinone)
- Coumadin (warfarin)
- Crestor (rosuvastatin)
- Cymbalta (duloxetine)
- Eliquis (apixaban)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Lantus (insulin glargine)
- Lasix (furosemide)
- Lexapro (escitalopram)
- Lipitor (atorvastatin)
- Lyrica (pregabalin)
- Nexium (esomeprazole)
- Norco (acetaminophen / hydrocodone)
- Plavix (clopidogrel)
- Protonix (pantoprazole)
- Singulair (montelukast)
- Synthroid (levothyroxine)
- Tylenol (acetaminophen)
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xarelto (rivaroxaban)
- Zoloft (sertraline)
- Zyrtec (cetirizine)
Metoprolol alcohol/food interactions
There are 4 alcohol/food interactions with metoprolol.
Metoprolol disease interactions
There are 19 disease interactions with metoprolol which include:
- bradyarrhythmia/AV block
- cardiogenic shock/hypotension
- CHF
- diabetes
- hemodialysis
- hypersensitivity
- ischemic heart disease
- PVD
- liver disease
- cerebrovascular insufficiency
- glaucoma
- hyperlipidemia
- hyperthyroidism
- hyperthyroidism PKs
- myasthenia gravis
- pheochromocytoma
- psoriasis
- tachycardia
- asthma/COPD
Report options
Loading…
QR code containing a link to this page
More about metoprolol
- metoprolol consumer information
- Compare alternatives
- Reviews (628)
- Drug images
- Side effects
- Dosage information
- Patient tips
- During pregnancy
- Support group
- Drug class: cardioselective beta blockers
- Breastfeeding
- En español
Related treatment guides
- Angina
- Atrial Fibrillation
- Angina Pectoris Prophylaxis
- Aortic Aneurysm
Drug Interaction Classification
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
|---|---|
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
| Unknown | No interaction information available. |
The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Metoprolol Pill Images – What does metoprolol look like?
Save
What does Metoprolol tartrate look like?
Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi ingredient medications may also be listed when applicable.
Return to Pill Identifier…
Results for “Metoprolol tartrate” (
1 – 18 of 102)
1 / 6
Metoprolol Tartrate
- Strength
- 50 mg
- Imprint
- M 32
- Color
- Pink
- Shape
- Round
View details
1 / 6
Metoprolol Tartrate
- Strength
- 100 mg
- Imprint
- M 47
- Color
- Blue
- Shape
- Round
View details
1 / 2
Metoprolol Tartrate
- Strength
- 100 mg
- Imprint
- GG 415
- Color
- White
- Shape
- Round
View details
1 / 4
Metoprolol Tartrate
- Strength
- 100 mg
- Imprint
- 167
- Color
- White
- Shape
- Oval
View details
Metoprolol Tartrate
- Strength
- 50 mg
- Imprint
- GG 414
- Color
- White
- Shape
- Capsule-shape
View details
Metoprolol Tartrate
- Strength
- 100 mg
- Imprint
- GG 415
- Color
- White
- Shape
- Capsule-shape
View details
1 / 2
Metoprolol Tartrate
- Strength
- 50 mg
- Imprint
- MP 184
- Color
- Orange
- Shape
- Rectangle
View details
1 / 2
Metoprolol Tartrate
- Strength
- 100 mg
- Imprint
- MP 185
- Color
- Yellow
- Shape
- Rectangle
View details
1 / 3
Metoprolol Tartrate
- Strength
- 50 mg
- Imprint
- 93 733
- Color
- Pink
- Shape
- Round
View details
1 / 2
Metoprolol Tartrate
- Strength
- 100 mg
- Imprint
- 93 734
- Color
- Blue
- Shape
- Round
View details
Metoprolol Tartrate
- Strength
- 50 mg
- Imprint
- 50 N 727
View details
1 / 4
Metoprolol Tartrate
- Strength
- 50 mg
- Imprint
- WATSON 462
- Color
- Pink
- Shape
- Round
View details
1 / 2
Metoprolol Tartrate
- Strength
- 100 mg
- Imprint
- WATSON 463
- Color
- Blue
- Shape
- Round
View details
1 / 5
Metoprolol Tartrate
- Strength
- 25 mg
- Imprint
- M 18
- Color
- White
- Shape
- Round
View details
Metoprolol Tartrate
- Strength
- 50 mg
- Imprint
- 554 R
- Shape
- Round
View details
1 / 2
Metoprolol Tartrate
- Strength
- 50 mg
- Imprint
- 166
- Color
- White
- Shape
- Oval
View details
1 / 4
Metoprolol Tartrate
- Strength
- 25 mg
- Imprint
- 1
- Color
- White
- Shape
- Round
View details
Metoprolol Tartrate
- Strength
- 100 mg
- Imprint
- 100 N 734
- Color
- White
- Shape
- Oval
View details
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
What helps, analogs, prescription, dosage, mechanism of action
THERE ARE CONTRAINDICATIONS. POSSIBLE SIDE EFFECTS. A SPECIALIST’S CONSULTATION IS REQUIRED.
Podoinitsyna Alena Andreevna,
Diploma in Pharmaceutical Education: 105924 3510722 reg. number 31917
All authors
Content of the article
- Metoprolol: mechanism of action
- Metoprolol: from what
- Metoprolol: prescription
- Metoprolol: dosage
- Metoprolol: analogues
- Metoprolol or Egilok: which is better
- Anaprilin or Metoprolol: which is better
- Summary
- Ask an expert on the topic of the article
Hypertension is a chronic disease, the main manifestation of which is an increase in blood pressure.
High blood pressure is responsible for 10 million deaths and 200 million disabilities worldwide. Symptoms of hypertension are either absent or nonspecific: headache, dizziness, palpitations.
Hypertension can and should be treated and controlled with medicines. We asked the pharmacist Alena Podoinitsyna to tell us about the drug Metoprolol: what it is prescribed for, in what dosages it is produced and what is the mechanism of action of the drug. They gave several examples of analogues of Metoprolol, and also compared it with Egilok and Anaprilin.
All products Metoprolol
20 reviews
Metoprolol: mechanism of action
Metoprolol is a medicine that is taken for high blood pressure. The drug blocks beta-adrenergic receptors. Blockade of beta-adrenergic receptors leads to a decrease in the number of heart contractions, contractility and speed of contraction of the heart muscle, while reducing myocardial oxygen demand.
Metoprolol: from what
We understand what Metoprolol tablets are from.
The drug has antihypertensive, antianginal and antiarrhythmic effects. Metoprolol is a beta-blocker. It helps to reduce pressure at rest, during stress and physical exertion.
Antianginal effect is manifested in a decrease in heart rate and a decrease in the heart’s need for oxygen. The antiarrhythmic effect is expressed in the elimination of tachycardia, a decrease in the excitability of the heart and the conduction of nerve impulses in its tissues.
Metoprolol: indications for use
- high blood pressure
- angina pectoris
- complex therapy after a heart attack
- arrhythmia, tachycardia
- migraine prophylaxis
- hyperthyroidism
Prescription metoprolol
Metoprolol is a prescription drug. When buying it, a pharmacy employee will ask you to provide a prescription from a doctor. The drug is available by prescription, as when used in recommended doses, the patient can harm himself.
Metoprolol has side effects and contraindications. Only a doctor can evaluate the benefit-risk ratio of the drug. Therefore, the decision on the need for his appointment is also made by the doctor.
Metoprolol: contraindications for use
- hypersensitivity to any component of the preparation
- atrioventricular block II and III degree
- heart failure in the stage of decompensation
- patient therapy with nootropics acting on beta-adrenergic receptors
- decrease in heart rate below 60 beats per minute
- cardiogenic shock
- circulatory disorders in the organs, or the threat of gangrene
- low blood pressure
- acute myocardial infarction
- lactose intolerance, glucose-galactose malabsorption
- children under 18 years of age
- severe form of bronchial asthma and chronic obstructive pulmonary disease.
- concomitant use of certain groups of drugs
- lactation
Metoprolol: dosage
Metoprolol contains the active ingredient: metoprolol tartrate, at a dosage of 100 mg per 1 tablet.
But we note that Metoprolol is produced on the basis of 2 active ingredients, or rather, salts. Each of them carries an action peculiar only to it.
- Metoprolol tartrate – the substance is contained in tablets of immediate action, these tablets must be taken several times a day.
- Metoprolol succinate – the substance is contained in tablets with a delayed release, respectively, such tablets are drunk 1 time per day.
Metoprolol: analogues
In order to choose metoprolol analogues and substitutes, a specialist consultation is necessary. Egilok, Serdol, Metocard, Betalok, Betalok ZOK contain metoprolol as an active substance. Metoprolol can be replaced with them without consulting a doctor. We recommend that you consult with a pharmacy employee or a pharmacist in the chat on our service. The specialist will help you choose the right dosage and dosage form.
The need to change to drugs with a different active substance is determined by the doctor.
Metoprolol is part of the combined preparations. For example, Logimax, Implicor, Hypotef. They, in addition to metoprolol, contain other active ingredients. You can not replace them with a simple Metoprolol.
Do you want to understand the analogues of drugs in order to skillfully select drugs for your budget? Our manual from expert pharmacists “Analogues of popular drugs” will help you with this! Getting a training manual is easy: subscribe to our social networks and write “analogues” in the messages.
Megapharmacy in social networks: VKontakte, Telegram, OK, Viber
Metoprolol or Egilok: which is better
When choosing the best drug, you should first consult with your doctor. There are practically no differences between Metoprolol and Egilok. Preparations differ by manufacturers:
- Metoprolol is produced in Russia, Slovenia, Israel, Slovakia and Germany
- Egilok is produced only in Hungary.
Other characteristics, such as: mechanism of action, indications for use, contraindications, side effects and other special indications, are the same for both drugs. All characteristics depend on the active substance. In both preparations, it is metoprolol tartrate. Therefore, Egilok is a substitute for Metoprolol.
Anaprilin or Metoprolol: which is better
Both drugs belong to the same group of drugs – beta-blockers. But the active ingredients are different. Anaprilin contains propranolol hydrochloride.
The difference between active substances lies in the mechanism of their action.
- Metoprolol is a non-selective adrenoblocker and acts on beta1-adrenergic receptors
- Anaprilin is selective and acts on beta1- and beta2-adrenergic receptors.
Thus, Anaprilin has more side effects and contraindications than Metoprolol. For example: both drugs should be taken with caution in diabetes mellitus.
Metoprolol is also with caution in: chronic obstructive pulmonary disease and bronchial asthma, and Anaprilin is completely contraindicated.
Preparations and manufacturers differ.
- Anaprilin is produced by Russia and Ukraine
- Metoprolol is produced by Russia and 4 other countries.
Follow your doctor’s advice to select the best drug.
All products Egilok
20 reviews
All products Anaprilin
21 reviews
Summary
- Metoprolol is an antihypertensive drug that is often prescribed for the treatment of hypertension, coronary heart disease and arrhythmias.
- Metoprolol is a prescription drug and is available only on prescription.
- The active substance of metoprolol is the salt of metoprolol succinate or tartrate.
- Metoprolol lowers blood pressure by reducing the heart’s need for oxygen and reducing the heart rate.
- Metoprolol has 4 analogues with which it can be substituted.
- When comparing Metoprolol with Egilok, differences were found only in manufacturers.
- Anaprilin differs from Metoprolol not only in producing companies, but also in the active substance.
Ask an expert about the topic of the article
Still have questions? Ask them in the comments below and our experts will answer you. There you can also share your experience with other readers of Megasovets.
Managing editor
Zotina Natalya Igorevna,
Expert pharmacist
Tell mom, dad, grandma and aunt Galya from the third entrance
Copy link
Metoprolol prescription in Stary Oskol: 508 items: free shipping, 30% discount [link]
Affiliate programHelp
Stary Oskol 9000 5
Catalog
Product Catalog
Clothing and footwear
Clothing and footwear
Building materials
Building materials
Textiles and leather
Textiles and leather
Health and beauty
Health and beauty 9000 5 Children’s goods
Children’s goods
Food and drinks
Food and drink
Electrical engineering
Electrical engineering
Home and garden
Home and garden
Furniture and interior
Furniture and interior
Agriculture
Agriculture
Industry
Industry
All categories
InputSelected
Recipe -Holding Thematic Exam tasks for preparing for passing theoretical exams for the right to drive vehicles of categories “A”, “B” , “M” and subcategories “A1”, “B1” from
DETAILS
Beer graphics (Pierre E.
, Pham A.)
DETAILS
Russian craft. The Great Craft Revolution (Egorov R.)
MORE INFO
Grandmother Agafia’s Recipes / Face Cream/Nourishing/Expert Nutrition Day+Night, 100 ml, Grandmother Agafia’s Recipes
DETAILS
90 002 Recipes granny Agafia face cream expert-nutrition day+ night, 100 ml Brand: Recipes grandmother
DETAILS
-22%
366
467
Recipes grandmother Aha fii Night face cream “Cellular rejuvenation of triple action” 100ml Brand:
MORE DETAILS
-17%
489
590
Grandmother Agafya’s recipes Triple Action Night Cellular Rejuvenation Face Cream 100 ml Brand: 900 05 MORE DETAILS
Grandmother Agafia’s recipes Facial cream triple night cellular rejuvenation action 100 ml, 2 packs.
MORE DETAILS
-14%
Recipes Grandmother Agafya Bathhouse Agafya Seven-strong hair mask 100 ml Brand: Recipes grandmother
MORE INFO
Recipes grandmother Agafya face cream expert-moisturizing day + night, 100 ml Brand: Recipes grandmother
MORE DETAILS 9 0005
Recipes grandmother Agafia / Recipes grandmother Agafia cream for face expert-moisturizing day + night, 100 ml, s granny Agafia face cream expert-nutrition day+night, 100 ml Brand : Recipes grandmother
MORE DETAILS
Recipes grandmother Agafya / Recipes Grandmother Agafia Blue Cleansing face mask with cornflower blue water, 100 ml, Recipes grandmother Agafya
DETAILS
-25%
443
590
Recipes granny Agafya face cream expert nutrition day+night, 100 ml0004 Grandmother Agafya Face cream “Expert nutrition” day + night 100ml Brand: Recipes grandmother
DETAILS 100 ml G-KD-371801008
MORE INFO
Recipes grandmother Agafya Bathhouse Agafya Seven-strong hair mask 100 ml Brand: Recipes grandmother
Gafi Face Cream Expert-Nutrition Day and Night 100 ml, 2 pcs Brand: Recipes grandmother
DETAILS
Recipes grandmother Agafya / Night cream, cellular rejuvenation of triple action, 100 ml, Recipes grandmother Agafya
MORE DETAILS
Recipes of grandmother Agafya.