What are the potential side effects of Humira injections. How can patients manage risks associated with Humira treatment. What safety precautions should be taken when using Humira. Who should avoid taking Humira due to health concerns.

Understanding Humira: Uses and Mechanisms

Humira (adalimumab) is a prescription medication used to treat various inflammatory conditions. Its primary use is to reduce signs and symptoms of moderate to severe hidradenitis suppurativa in patients 12 years and older. But what exactly is Humira, and how does it work?

Humira belongs to a class of drugs known as TNF (tumor necrosis factor) blockers. These medications work by suppressing specific components of the immune system that contribute to inflammation. By targeting TNF, Humira can help alleviate symptoms associated with autoimmune disorders.

Common Conditions Treated with Humira

• Rheumatoid arthritis
• Psoriatic arthritis
• Ankylosing spondylitis
• Crohn’s disease
• Ulcerative colitis
• Plaque psoriasis
• Juvenile idiopathic arthritis

While Humira has proven effective for many patients, it’s crucial to understand its potential side effects and safety considerations before starting treatment.

Serious Infection Risks Associated with Humira

One of the most significant concerns when using Humira is the increased risk of serious infections. But why does this happen, and what types of infections are patients at risk for?

Humira works by suppressing parts of the immune system, which can leave the body more vulnerable to infections. This includes both common and opportunistic infections that might not typically affect healthy individuals.

Types of Infections to Watch For

• Tuberculosis (TB)
• Fungal infections
• Bacterial infections
• Viral infections

It’s important to note that some people have died from these infections while taking Humira. This underscores the critical nature of proper screening and monitoring during treatment.

Tuberculosis Screening and Monitoring

Given the increased risk of TB in patients taking Humira, doctors typically follow a strict protocol for screening and monitoring. What does this process involve?

1. TB testing before starting Humira
2. Regular check-ups for signs and symptoms of TB during treatment
3. Possible preventive TB treatment for high-risk patients

Even if your initial TB test is negative, your doctor will continue to monitor you closely throughout your treatment with Humira.

Cancer Risks and Humira: What Patients Need to Know

Another serious concern associated with Humira and other TNF blockers is an increased risk of certain cancers. But what types of cancers are of particular concern, and who is most at risk?

While the overall risk remains relatively low, studies have shown an increased incidence of certain cancers in patients taking TNF blockers like Humira. This risk appears to be higher in children, teenagers, and young adults.

Types of Cancer Associated with TNF Blockers

• Lymphoma
• Hepatosplenic T-cell lymphoma (a rare but often fatal type)
• Skin cancers (basal cell and squamous cell carcinoma)

It’s important to note that while the risk of these cancers is increased, the absolute risk remains low for most patients. However, vigilance and regular check-ups are crucial for early detection and treatment.

Skin Cancer Awareness

Patients taking Humira should be particularly aware of potential skin changes. What should you look out for?

• New bumps or growths on the skin
• Open sores that don’t heal
• Changes in existing moles or skin lesions

If you notice any of these changes, it’s important to inform your doctor promptly. Early detection and treatment of skin cancers can significantly improve outcomes.

Pre-Treatment Considerations: What to Tell Your Doctor

Before starting Humira, it’s crucial to have an open and honest discussion with your healthcare provider about your medical history and current health status. What information should you share with your doctor?

Key Information to Disclose

• Current or recent infections
• History of recurring infections
• Diabetes diagnosis
• Tuberculosis exposure or risk factors
• Travel to or residence in areas with increased fungal infection risk
• Any other chronic health conditions

By providing your doctor with a comprehensive health picture, you can help ensure that Humira is a safe and appropriate treatment option for you.

Geographic Considerations

Interestingly, your geographic location can play a role in your risk profile for certain infections when taking Humira. Why is this the case?

Some regions, such as the Ohio and Mississippi River valleys, have a higher prevalence of certain fungal infections. If you live in or have traveled to these areas, your doctor may need to take extra precautions or conduct additional screening tests.

Managing Humira Treatment: Injection Site Reactions

While systemic side effects are a significant concern, many patients also experience localized reactions at the injection site. How common are these reactions, and how can they be managed?

Injection site reactions are one of the most common side effects of Humira, affecting up to 20% of patients. These reactions are typically mild and manageable, but understanding how to minimize and treat them can improve your treatment experience.

Common Injection Site Reactions

• Redness
• Swelling
• Itching
• Bruising
• Pain

Most of these reactions are temporary and resolve on their own within a few days. However, if you experience severe or persistent reactions, it’s important to consult your healthcare provider.

Tips for Minimizing Injection Site Reactions

1. Rotate injection sites regularly
2. Allow Humira to reach room temperature before injecting
3. Use proper injection technique (your healthcare provider can demonstrate this)
4. Apply a cold compress to the injection site before and after administration
5. Consider using over-the-counter antihistamines for itching

By following these tips, many patients find they can significantly reduce the frequency and severity of injection site reactions.

Humira and Pregnancy: Weighing the Risks and Benefits

For women of childbearing age, the decision to use Humira requires careful consideration of potential risks to both mother and fetus. What do we know about the safety of Humira during pregnancy?

While data on the use of Humira during pregnancy is limited, some studies have been conducted to assess its safety. The decision to use Humira during pregnancy should be made on a case-by-case basis, weighing the potential benefits against the risks.

Current Understanding of Humira in Pregnancy

• Humira is classified as a Pregnancy Category B drug by the FDA
• Animal studies have not shown evidence of harm to the fetus
• Limited human data suggests low risk, but more research is needed
• Humira can cross the placenta, especially in the third trimester

If you’re pregnant or planning to become pregnant, it’s crucial to discuss your treatment options with your healthcare provider. They can help you make an informed decision based on your individual circumstances and the latest available research.

Considerations for Breastfeeding

What about using Humira while breastfeeding? The current guidance is as follows:

• Small amounts of Humira can pass into breast milk
• The effects on the nursing infant are not well understood
• The benefits of breastfeeding should be weighed against potential risks

As with pregnancy, the decision to use Humira while breastfeeding should be made in consultation with your healthcare provider.

Long-Term Use of Humira: What to Expect

For many patients, Humira is a long-term treatment option. But what should patients expect when using Humira over an extended period? Are there additional risks or considerations?

Long-term use of Humira can be effective in managing chronic inflammatory conditions. However, it also requires ongoing monitoring and awareness of potential side effects.

Long-Term Monitoring

Patients on long-term Humira therapy typically undergo:

• Regular blood tests to check liver function and blood cell counts
• Periodic screening for tuberculosis
• Skin examinations to check for potential skin cancers
• Monitoring for signs of neurological problems

Your healthcare provider will establish a monitoring schedule based on your individual risk factors and response to treatment.

Potential Long-Term Side Effects

While many side effects of Humira are short-term, some patients may experience effects from long-term use. These can include:

• Increased susceptibility to infections
• Potential increased risk of certain cancers
• Liver problems
• Neurological issues (rare)

It’s important to maintain open communication with your healthcare provider about any new or changing symptoms throughout your treatment.

Navigating Insurance and Cost Considerations for Humira

While the medical considerations of Humira are paramount, many patients also face challenges related to insurance coverage and cost. How can patients navigate these financial aspects of Humira treatment?

Humira is a biologic medication, which means it can be quite expensive. However, there are several strategies patients can use to manage costs and ensure access to this important medication.

Insurance Coverage for Humira

Most insurance plans cover Humira, but coverage can vary. Here are some key points to consider:

• Prior authorization is often required
• Some plans may require step therapy (trying other medications first)
• Co-pays and deductibles can be significant

It’s important to review your insurance coverage carefully and discuss any concerns with your healthcare provider or insurance company.

Patient Assistance Programs

For patients struggling with the cost of Humira, several assistance programs are available:

• AbbVie’s patient assistance program for uninsured or underinsured patients
• Co-pay assistance cards for commercially insured patients
• Non-profit organizations offering financial assistance for medication costs

Your healthcare provider or a patient advocate can help you explore these options and find the best solution for your situation.

Understanding the potential side effects and safety considerations of Humira is crucial for patients considering or currently undergoing this treatment. While the risks can be significant, for many patients, the benefits of Humira in managing their condition outweigh these potential side effects. Always work closely with your healthcare provider to monitor your treatment and address any concerns promptly. With proper care and vigilance, many patients find that Humira can significantly improve their quality of life and help manage their chronic inflammatory conditions effectively.

Safety Info and Side Effects

HUMIRA Use

¹

HUMIRA is a prescription medicine used to reduce the signs and symptoms of moderate to severe hidradenitis suppurativa in people 12 years and older.

IMPORTANT SAFETY INFORMATION

¹

You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test

IMPORTANT SAFETY INFORMATION

¹

You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test

HUMIRA Use

¹

HUMIRA is a prescription medicine used to reduce the signs and symptoms of moderate to severe hidradenitis suppurativa in people 12 years and older.

IMPORTANT SAFETY INFORMATION

¹

You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.

Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of

IMPORTANT SAFETY INFORMATION

¹

You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.

Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of

HUMIRA Use

¹

HUMIRA is a prescription medicine used to reduce the signs and symptoms of moderate to severe hidradenitis suppurativa in people 12 years and older.

IMPORTANT SAFETY INFORMATION 

ABOUT HUMIRA^® (adalimumab)¹

What is the most important information I should know about HUMIRA?

You should discuss the potential benefits and risks of HUMIRA with your doctor. HUMIRA is a TNF blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay.

• Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.
• Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. There have been cases of unusual cancers in children, teenagers, and young adults using TNF blockers. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers including HUMIRA, your chance of getting two types of skin cancer (basal cell and squamous cell) may increase. These types are generally not life-threatening if treated; tell your doctor if you have a bump or open sore that doesn’t heal.

What should I tell my doctor BEFORE starting HUMIRA?

Tell your doctor about all of your health conditions, including if you:

• Have an infection, are being treated for infection, or have symptoms of an infection
• Get a lot of infections or infections that keep coming back
• Have diabetes
• Have TB or have been in close contact with someone with TB, or were born in, lived in, or traveled where there is more risk for getting TB
• Live or have lived in an area (such as the Ohio and Mississippi River valleys) where there is an increased risk for getting certain kinds of fungal infections, such as histoplasmosis, coccidioidomycosis, or blastomycosis. These infections may happen or become more severe if you use HUMIRA. Ask your doctor if you are unsure if you have lived in these areas
• Have or have had hepatitis B
• Are scheduled for major surgery
• Have or have had cancer
• Have numbness or tingling or a nervous system disease such as multiple sclerosis or Guillain-Barré syndrome
• Have or had heart failure
• Have recently received or are scheduled to receive a vaccine. HUMIRA patients may receive vaccines, except for live vaccines. Children should be brought up to date on all vaccines before starting HUMIRA
• Are allergic to rubber, latex, or any HUMIRA ingredients
• Are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed
• Have a baby and you were using HUMIRA during your pregnancy. Tell your baby’s doctor before your baby receives any vaccines

Also tell your doctor about all the medicines you take. You should not take HUMIRA with ORENCIA^® (abatacept), KINERET^® (anakinra), REMICADE^® (infliximab), ENBREL^® (etanercept), CIMZIA^® (certolizumab pegol), or SIMPONI^® (golimumab). Tell your doctor if you have ever used RITUXAN^® (rituximab), IMURAN^® (azathioprine), or PURINETHOL^® (mercaptopurine, 6-MP).

What should I watch for AFTER starting HUMIRA?

HUMIRA can cause serious side effects, including:

• Serious infections. These include TB and infections caused by viruses, fungi, or bacteria. Symptoms related to TB include a cough, low-grade fever, weight loss, or loss of body fat and muscle.
• Hepatitis B infection in carriers of the virus. Symptoms include muscle aches, feeling very tired, dark urine, skin or eyes that look yellow, little or no appetite, vomiting, clay-colored bowel movements, fever, chills, stomach discomfort, and skin rash.
• Allergic reactions. Symptoms of a serious allergic reaction include hives, trouble breathing, and swelling of your face, eyes, lips, or mouth.
• Nervous system problems. Signs and symptoms include numbness or tingling, problems with your vision, weakness in your arms or legs, and dizziness.
• Blood problems (decreased blood cells that help fight infections or stop bleeding). Symptoms include a fever that does not go away, bruising or bleeding very easily, or looking very pale.
• Heart failure (new or worsening). Symptoms include shortness of breath, swelling of your ankles or feet, and sudden weight gain.
• Immune reactions including a lupus-like syndrome. Symptoms include chest discomfort or pain that does not go away, shortness of breath, joint pain, or rash on your cheeks or arms that gets worse in the sun.
• Liver problems. Symptoms include feeling very tired, skin or eyes that look yellow, poor appetite or vomiting, and pain on the right side of your stomach (abdomen). These problems can lead to liver failure and death.
• Psoriasis (new or worsening). Symptoms include red scaly patches or raised bumps that are filled with pus.

Call your doctor or get medical care right away if you develop any of the above symptoms.

Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or that does not go away.

Remember, tell your doctor right away if you have an infection or symptoms of an infection, including:

• Fever, sweats, or chills
• Muscle aches
• Cough
• Shortness of breath
• Blood in phlegm
• Weight loss
• Warm, red, or painful skin or sores on your body
• Diarrhea or stomach pain
• Burning when you urinate
• Urinating more often than normal
• Feeling very tired

HUMIRA is given by injection under the skin.

This is the most important information to know about HUMIRA. For more information, talk to your health care provider.

Uses

HUMIRA is a prescription medicine used:

• To reduce the signs and symptoms of:
  • Moderate to severe rheumatoid arthritis (RA) in adults. HUMIRA can be used alone, with methotrexate, or with certain other medicines. HUMIRA may prevent further damage to your bones and joints and may help your ability to perform daily activities.
  • Moderate to severe polyarticular juvenile idiopathic arthritis (JIA) in children 2 years of age and older. HUMIRA can be used alone or with methotrexate.
  • Psoriatic arthritis (PsA) in adults. HUMIRA can be used alone or with certain other medicines. HUMIRA may prevent further damage to your bones and joints and may help your ability to perform daily activities.
  • Ankylosing spondylitis (AS) in adults.
  • Moderate to severe hidradenitis suppurativa (HS) in people 12 years and older.
• To treat moderate to severe Crohn’s disease (CD) in adults and children 6 years of age and older.
• To treat moderate to severe ulcerative colitis (UC) in adults and children 5 years of age and older. It is not known if HUMIRA is effective in people who stopped responding to or could not tolerate anti-TNF medicines.
• To treat moderate to severe chronic plaque psoriasis (Ps) in adults who are ready for systemic therapy or phototherapy, and are under the care of a doctor who will decide if other systemic therapies are less appropriate.
• To treat non-infectious intermediate (middle part of the eye), posterior (back of the eye), and panuveitis (all parts of the eye) in adults and children 2 years of age and older.

US-HUM-210186

HUMIRA® (adalimumab) | A Biologic Treatment Option

IMPORTANT SAFETY INFORMATION

¹

You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.

IMPORTANT SAFETY INFORMATION

¹

You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay. Serious infections have happened in people taking HUMIRA. These serious infections include

IMPORTANT SAFETY INFORMATION

¹

You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.

Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. There have been cases of

unusual

IMPORTANT SAFETY INFORMATION

¹

You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay. Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections.

IMPORTANT SAFETY INFORMATION 

ABOUT HUMIRA^® (adalimumab)¹

What is the most important information I should know about HUMIRA?

You should discuss the potential benefits and risks of HUMIRA with your doctor. HUMIRA is a TNF blocker medicine that can lower the ability of your immune system to fight infections. You should not start taking HUMIRA if you have any kind of infection unless your doctor says it is okay.

• Serious infections have happened in people taking HUMIRA. These serious infections include tuberculosis (TB) and infections caused by viruses, fungi, or bacteria that have spread throughout the body. Some people have died from these infections. Your doctor should test you for TB before starting HUMIRA, and check you closely for signs and symptoms of TB during treatment with HUMIRA, even if your TB test was negative. If your doctor feels you are at risk, you may be treated with medicine for TB.
• Cancer. For children and adults taking TNF blockers, including HUMIRA, the chance of getting lymphoma or other cancers may increase. There have been cases of unusual cancers in children, teenagers, and young adults using TNF blockers. Some people have developed a rare type of cancer called hepatosplenic T-cell lymphoma. This type of cancer often results in death. If using TNF blockers including HUMIRA, your chance of getting two types of skin cancer (basal cell and squamous cell) may increase. These types are generally not life-threatening if treated; tell your doctor if you have a bump or open sore that doesn’t heal.

What should I tell my doctor BEFORE starting HUMIRA?

Tell your doctor about all of your health conditions, including if you:

• Have an infection, are being treated for infection, or have symptoms of an infection
• Get a lot of infections or infections that keep coming back
• Have diabetes
• Have TB or have been in close contact with someone with TB, or were born in, lived in, or traveled where there is more risk for getting TB
• Live or have lived in an area (such as the Ohio and Mississippi River valleys) where there is an increased risk for getting certain kinds of fungal infections, such as histoplasmosis, coccidioidomycosis, or blastomycosis. These infections may happen or become more severe if you use HUMIRA. Ask your doctor if you are unsure if you have lived in these areas
• Have or have had hepatitis B
• Are scheduled for major surgery
• Have or have had cancer
• Have numbness or tingling or a nervous system disease such as multiple sclerosis or Guillain-Barré syndrome
• Have or had heart failure
• Have recently received or are scheduled to receive a vaccine. HUMIRA patients may receive vaccines, except for live vaccines. Children should be brought up to date on all vaccines before starting HUMIRA
• Are allergic to rubber, latex, or any HUMIRA ingredients
• Are pregnant, planning to become pregnant, breastfeeding, or planning to breastfeed
• Have a baby and you were using HUMIRA during your pregnancy. Tell your baby’s doctor before your baby receives any vaccines

Also tell your doctor about all the medicines you take. You should not take HUMIRA with ORENCIA^® (abatacept), KINERET^® (anakinra), REMICADE^® (infliximab), ENBREL^® (etanercept), CIMZIA^® (certolizumab pegol), or SIMPONI^® (golimumab). Tell your doctor if you have ever used RITUXAN^® (rituximab), IMURAN^® (azathioprine), or PURINETHOL^® (mercaptopurine, 6-MP).

What should I watch for AFTER starting HUMIRA?

HUMIRA can cause serious side effects, including:

• Serious infections. These include TB and infections caused by viruses, fungi, or bacteria. Symptoms related to TB include a cough, low-grade fever, weight loss, or loss of body fat and muscle.
• Hepatitis B infection in carriers of the virus. Symptoms include muscle aches, feeling very tired, dark urine, skin or eyes that look yellow, little or no appetite, vomiting, clay-colored bowel movements, fever, chills, stomach discomfort, and skin rash.
• Allergic reactions. Symptoms of a serious allergic reaction include hives, trouble breathing, and swelling of your face, eyes, lips, or mouth.
• Nervous system problems. Signs and symptoms include numbness or tingling, problems with your vision, weakness in your arms or legs, and dizziness.
• Blood problems (decreased blood cells that help fight infections or stop bleeding). Symptoms include a fever that does not go away, bruising or bleeding very easily, or looking very pale.
• Heart failure (new or worsening). Symptoms include shortness of breath, swelling of your ankles or feet, and sudden weight gain.
• Immune reactions including a lupus-like syndrome. Symptoms include chest discomfort or pain that does not go away, shortness of breath, joint pain, or rash on your cheeks or arms that gets worse in the sun.
• Liver problems. Symptoms include feeling very tired, skin or eyes that look yellow, poor appetite or vomiting, and pain on the right side of your stomach (abdomen). These problems can lead to liver failure and death.
• Psoriasis (new or worsening). Symptoms include red scaly patches or raised bumps that are filled with pus.

Call your doctor or get medical care right away if you develop any of the above symptoms.

Common side effects of HUMIRA include injection site reactions (pain, redness, rash, swelling, itching, or bruising), upper respiratory infections (sinus infections), headaches, rash, and nausea. These are not all of the possible side effects with HUMIRA. Tell your doctor if you have any side effect that bothers you or that does not go away.

Remember, tell your doctor right away if you have an infection or symptoms of an infection, including:

• Fever, sweats, or chills
• Muscle aches
• Cough
• Shortness of breath
• Blood in phlegm
• Weight loss
• Warm, red, or painful skin or sores on your body
• Diarrhea or stomach pain
• Burning when you urinate
• Urinating more often than normal
• Feeling very tired

HUMIRA is given by injection under the skin.

This is the most important information to know about HUMIRA. For more information, talk to your health care provider.

Uses

HUMIRA is a prescription medicine used:

• To reduce the signs and symptoms of:
  • Moderate to severe rheumatoid arthritis (RA) in adults. HUMIRA can be used alone, with methotrexate, or with certain other medicines. HUMIRA may prevent further damage to your bones and joints and may help your ability to perform daily activities.
  • Moderate to severe polyarticular juvenile idiopathic arthritis (JIA) in children 2 years of age and older. HUMIRA can be used alone or with methotrexate.
  • Psoriatic arthritis (PsA) in adults. HUMIRA can be used alone or with certain other medicines. HUMIRA may prevent further damage to your bones and joints and may help your ability to perform daily activities.
  • Ankylosing spondylitis (AS) in adults.
  • Moderate to severe hidradenitis suppurativa (HS) in people 12 years and older.
• To treat moderate to severe Crohn’s disease (CD) in adults and children 6 years of age and older.