Sodium chloride tablets side effects. Sodium Chloride Tablets: Benefits, Side Effects, and Proper Use for Athletes

01.08.202327.06.2023 by alexxlab

What are the benefits of sodium chloride tablets for athletes. How do salt tablets affect hydration and electrolyte balance. What are the potential side effects and risks of using salt pills. When should athletes consider taking salt tablets versus other rehydration methods.

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Understanding Sodium Chloride Tablets and Their Role in Hydration

Sodium chloride tablets, commonly known as salt tablets or salt pills, have long been used by athletes and individuals engaged in strenuous physical activities to combat dehydration and maintain electrolyte balance. These tablets primarily contain sodium and chloride, two crucial electrolytes that play a vital role in maintaining proper bodily functions.

The human body requires a delicate balance of water and electrolytes to function optimally. During intense physical exertion or prolonged exposure to heat, significant amounts of these essential elements can be lost through sweat. This loss can lead to dehydration, heat cramps, and other health issues if not properly addressed.

How do salt tablets work?

Salt tablets work by replenishing the sodium and chloride lost through sweating. When consumed with adequate water, they help the body retain fluids and maintain proper electrolyte balance. This is particularly important for endurance athletes or individuals working in hot environments for extended periods.

Benefits of Sodium Chloride Tablets for Athletes

While the use of salt tablets has become less common with the rise of sports drinks, they still offer several benefits for athletes and active individuals:

Improved hydration and rehydration for long-distance athletes
Maintenance of electrolyte balance
Enhanced fluid retention during high-intensity exertion
Reduced risk of heat cramps

Do salt tablets improve performance in endurance events?

Research suggests that salt tablets can indeed improve performance in endurance events. A 2015 study found that oral salt supplementation helped improve electrolyte concentrations in the bloodstream and reduced water-weight loss during a half-Ironman race. This reduction in fluid loss can be crucial for maintaining organ function and overall performance during lengthy, strenuous activities.

When to Consider Using Salt Tablets

Salt tablets can be beneficial in specific situations, particularly for athletes and individuals engaged in prolonged physical activity. Consider using salt tablets:

When you’ll be physically active or in the heat for extended periods
If you’re not already well-hydrated before an activity
When taken with sufficient water

Are salt tablets suitable for everyday use?

For most people, salt tablets are not necessary for everyday use. Typically, drinking enough water and following a balanced diet are sufficient to maintain proper hydration and electrolyte balance during regular daily activities. Salt tablets are primarily beneficial in extreme circumstances, such as completing a marathon or working for hours in high temperatures.

Proper Usage and Dosage of Sodium Chloride Tablets

When using salt tablets, it’s crucial to follow proper guidelines to maximize benefits and minimize risks:

Always consume salt tablets with adequate water
Follow recommended dosage instructions
Use them only when necessary, such as during prolonged physical activity or heat exposure
Consider consulting with a healthcare professional before use, especially if you have underlying health conditions

How much water should be consumed with salt tablets?

The amount of water to consume with salt tablets can vary depending on the individual and the activity level. However, a general guideline is to drink at least 8-16 ounces (240-480 ml) of water with each salt tablet. This ensures proper dilution and helps prevent an unhealthy buildup of sodium in the body.

Potential Side Effects and Risks of Salt Tablets

While salt tablets can be beneficial in certain situations, they also come with potential side effects and risks:

Upset stomach
Excessive thirst due to increased sodium levels
Raised blood pressure, especially in individuals with hypertension
Risk of hypernatremia (too much sodium in the body)

What are the symptoms of hypernatremia?

Hypernatremia, or excessive sodium levels in the body, can cause several symptoms, including:

Extreme thirst
Fatigue and low energy
Confusion
Difficulty concentrating

If you experience these symptoms after taking salt tablets, it’s important to seek medical attention promptly.

Alternatives to Sodium Chloride Tablets

While salt tablets can be effective, there are several alternatives available for maintaining hydration and electrolyte balance:

Sports drinks containing electrolytes
Electrolyte-enhanced water
Natural sources of electrolytes (e.g., coconut water, bananas)
Homemade electrolyte solutions

Are sports drinks better than salt tablets?

Sports drinks have become increasingly popular as an alternative to salt tablets. They offer several advantages, including:

Balanced electrolyte content (sodium, potassium, magnesium, and phosphate)
Carbohydrates for energy
More palatable taste
Easier to consume during physical activity

However, the choice between sports drinks and salt tablets may depend on individual preferences, the specific activity, and any underlying health conditions.

Monitoring Hydration Levels

Regardless of whether you choose to use salt tablets or other hydration methods, it’s crucial to monitor your hydration levels during physical activity.

How can you tell if you’re properly hydrated?

One simple way to gauge your hydration level is by observing the color of your urine. Clear or pale yellow urine generally indicates good hydration, while dark yellow or amber-colored urine suggests dehydration. Other signs of proper hydration include:

Regular urination
Absence of excessive thirst
Moist mouth and lips
Elastic skin (quickly returns to its original position when pinched)

Special Considerations for Athletes and Active Individuals

Athletes and individuals engaged in regular intense physical activity should pay special attention to their hydration and electrolyte needs:

Develop a personalized hydration strategy based on individual sweat rates and activity levels
Consider consulting with a sports nutritionist or healthcare professional
Be aware of the signs of dehydration and electrolyte imbalance
Practice proper pre-hydration before engaging in strenuous activities

How can athletes determine their individual hydration needs?

Athletes can determine their individual hydration needs through several methods:

Sweat rate testing: Weigh yourself before and after exercise to calculate fluid loss
Urine specific gravity tests: Use dipsticks or a refractometer to measure urine concentration
Tracking fluid intake and output during training sessions
Working with a sports nutritionist to develop a personalized hydration plan

The Role of Sodium in the Body

Understanding the importance of sodium in the body can help athletes and active individuals make informed decisions about their hydration strategies.

Why is sodium essential for the human body?

Sodium plays several crucial roles in the human body:

Helps regulate fluid balance
Facilitates nerve impulse transmission
Aids in muscle contraction
Supports proper nutrient absorption in the intestines
Maintains blood pressure

While sodium is essential, it’s important to maintain a balance, as both too little and too much sodium can have negative health effects.

The Science Behind Electrolyte Balance

Electrolyte balance is a complex process involving multiple minerals and bodily systems. Understanding this science can help athletes optimize their performance and overall health.

How do electrolytes affect athletic performance?

Electrolytes play a crucial role in athletic performance by:

Regulating muscle contractions
Maintaining proper hydration
Balancing pH levels in the body
Supporting nerve function
Facilitating energy production and utilization

Imbalances in electrolytes can lead to decreased performance, muscle cramps, fatigue, and in severe cases, more serious health complications.

Environmental Factors Affecting Hydration and Electrolyte Balance

Various environmental factors can significantly impact an individual’s hydration needs and electrolyte balance:

Temperature and humidity levels
Altitude
Wind conditions
Sun exposure

How does altitude affect hydration needs?

High altitude can increase hydration needs due to several factors:

Increased respiratory rate and subsequent water loss through breathing
Lower humidity levels at higher altitudes, leading to increased evaporative losses
Potential diuretic effect of altitude on the body
Decreased thirst sensation at higher altitudes

Athletes training or competing at high altitudes may need to adjust their hydration strategies accordingly, potentially including the use of salt tablets or other electrolyte supplements.

Long-Term Health Considerations of Sodium Intake

While sodium is essential for short-term performance, it’s important to consider the long-term health implications of sodium intake, especially for athletes who may be using salt tablets regularly.

Can regular use of salt tablets lead to health issues?

Regular and excessive use of salt tablets may potentially lead to health issues such as:

Increased risk of high blood pressure
Kidney strain
Calcium loss, potentially affecting bone health
Stomach discomfort or ulcers

It’s crucial for athletes to balance their short-term performance needs with long-term health considerations. Consulting with a healthcare professional can help develop a sustainable approach to electrolyte management.

Personalized Approaches to Hydration and Electrolyte Balance

Given the individual variations in sweat rates, electrolyte losses, and overall physiology, a personalized approach to hydration and electrolyte balance is often the most effective strategy for athletes and active individuals.

How can athletes develop a personalized hydration strategy?

To develop a personalized hydration strategy, athletes can:

Work with a sports nutritionist or dietitian
Undergo sweat rate testing and electrolyte profile analysis
Experiment with different hydration methods during training
Keep a log of fluid intake, urine output, and performance metrics
Adjust strategies based on different environmental conditions and activity levels

By tailoring their approach, athletes can optimize their hydration and electrolyte balance for peak performance while minimizing health risks.

Future Trends in Hydration and Electrolyte Management

As sports science and technology continue to advance, new methods for managing hydration and electrolyte balance are emerging.

What innovations are on the horizon for hydration management?

Several innovative approaches to hydration and electrolyte management are being developed or refined:

Wearable devices that monitor hydration status in real-time
Personalized electrolyte formulations based on genetic testing
Advanced sweat analysis techniques for more accurate electrolyte loss measurement
Novel delivery methods for electrolytes, such as transdermal patches or micro-encapsulation
AI-powered hydration coaching systems

These advancements may provide athletes with more precise and effective tools for managing their hydration and electrolyte needs in the future.

Educating Athletes on Proper Hydration Practices

Proper education on hydration and electrolyte management is crucial for athletes at all levels, from amateur to professional.

What key points should be included in athlete hydration education?

Comprehensive hydration education for athletes should cover:

The physiological importance of proper hydration
Signs and symptoms of dehydration and electrolyte imbalances
Proper pre-hydration, during-activity hydration, and rehydration techniques
Understanding individual hydration needs based on factors like body composition, sweat rate, and activity level
The role of nutrition in overall hydration status
Safe and effective use of hydration aids, including salt tablets and sports drinks
Environmental factors affecting hydration needs
Long-term health considerations related to hydration and electrolyte management

By equipping athletes with this knowledge, they can make informed decisions about their hydration strategies and optimize their performance while maintaining good health.

What to Know About Using Salt Tablets

If you’re a distance runner or someone who works up a good sweat exercising or laboring for long periods of time, you probably know the importance of staying hydrated with fluids and maintaining healthy levels of certain minerals known as electrolytes.

Two electrolytes, sodium and chloride, are the key ingredients in table salt and in salt tablets. These tablets have been used for many years to treat heat cramps and restore electrolytes lost through sweating.

Salt tablets, also known as salt pills, aren’t recommended as much as they used to be, given that sports drinks are packed with additional electrolytes, including potassium, magnesium, and phosphate.

Some doctors still recommend salt tablets for limited use, but because of some health risks involved, salt tablet use is often discouraged in favor of other rehydration options.

Salt tablets can help in the following situations:

when you’ll be physically active or in the heat for extended periods of time
if you’re not already well-hydrated before an activity
when taken with water

Your body is healthiest when the water-sodium balance is just right.

Typically, drinking enough water and following a healthy diet are enough to keep everything working optimally while you go about your daily activities.

When you’re likely to sweat a lot

In extreme circumstances, like completing a marathon or working for hours in high temperatures, you run the risk of losing unhealthy amounts of water, sodium, and other electrolytes you need for healthy functioning.

When electrolyte and fluid levels in your body are low

When both fluid and sodium levels have fallen dramatically, drinking water isn’t enough. Without sodium and other electrolytes, your body won’t maintain a healthy fluid level, and the water you drink will quickly be lost.

When taken with enough water

Remember that every cell in your body and every bodily function relies on fluids to be healthy.

Taking salt tablets without drinking a lot of fluids can cause an unhealthy buildup of sodium. This will force your kidneys to expel more of that sodium in urine and sweat without making you feel more hydrated.

Taken with water, salt tablets can help long-distance runners and others at high risk for dehydration and heat cramps.

What kidneys do with salt and water

Normally, kidneys do a pretty good job of regulating fluid and sodium levels by retaining water or sodium or by excreting it in urine as circumstances dictate.

For example, if you consume more sodium by eating salty foods, your body will hold on to more water to try to maintain that water-sodium balance. And if you lose a lot of water through sweat, your body will release more sodium in sweat or urine to try to keep things balanced.

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Salt tablets can provide the following benefits:

act as a good hydration and rehydration method for long-distance athletes
help keep some electrolytes balanced
help you retain more fluids during high-intensity exertion and physical work

Consuming salt tablets and water will restore your sodium levels and help you retain more fluids in the process.

In a recent study of 16 healthy men, researchers found that sodium chloride solution-based hyperhydration did a better job of helping the men retain fluids during and after exercise than an alternative form of rehydration that uses glycerol.

The glycerol approach was actually banned in international athletic competition by the World Anti-Doping Agency for years until it was removed from the prohibited list in 2018.

A 2015 study found that oral salt supplementation helped improve electrolyte concentrations in the bloodstream and reduced water-weight loss during a half-Ironman race. That race features a 1.2-mile swim, 56-mile bicycle ride, and 13.1-mile run.

Weight loss that’s mostly comprised of water after an endurance race isn’t lasting. And losing too much water — even temporarily — can have a negative effect on organ function.

Being able to reduce the amount of fluids lost, with proper hydration and electrolyte intake, can make these types of activities less dangerous.

How to tell

One way to gauge your hydration level is the color of your urine.

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Salt tablet use can lead to the following side effects:

upset stomach
too much sodium in your body, which often results in being very thirsty
raised blood pressure
specific risks based on health conditions

Unfortunately, salt tablet use comes with some significant health risks, including stomach irritation.

Excessive sodium levels

Simply having too much sodium (hypernatremia) in the body can make you feel unwell.

Symptoms of hypernatremia include:

extreme thirst
fatigue and low energy
confusion
difficulty concentrating

Raised blood pressure with blood pressure conditions

High sodium levels can raise blood pressure, so individuals with high blood pressure (hypertension) who take antihypertensive medications may need to avoid salt tablets and a high-sodium diet.

Salt tablets and extra sodium can make hypertension medications less effective.

Some people with low blood pressure (hypotension) take salt tablets at the advice of their doctors, but they should be especially careful if also taking medications to raise blood pressure, such as midodrine (Orvaten).

Strain on the kidneys with kidney conditions

If you have kidney issues, too much sodium intake can worsen your condition by putting too much strain on the kidneys to balance sodium and fluid levels.

Consuming too much salt, for example, will force the kidneys to excrete more water and sodium to bring the sodium levels down to a healthy range.

When trying salt tablets, do the following:

Read the full ingredients list, electrolytes, and mineral breakdown.
Drink plenty of water.
Follow advice and use tips from medical professionals.

Even though they can be purchased over the counter and without a prescription, salt tablets are best used with a doctor’s supervision.

If you’re prone to heat cramps and other dehydration issues, your doctor may give you specific dosage instructions.

Certain brands of sodium chloride tablets also contain potassium, magnesium, and other electrolytes.

Check the label of any supplement to see how much of a particular ingredient is contained within, especially if your doctor has recommended you limit your consumption of a particular mineral.

What: Most common salt tablets are 1-gram pills that contain approximately 300 to 400 milligrams of sodium.
When: The tablets are dissolved in about 4 ounces of water and consumed shortly before or during a long bout of exercise or hard physical labor.

When not in use, salt tablets should be stored at room temperature in a dry location.

While salt tablets may be safe and helpful for distance runners and others who work up a powerful sweat, they aren’t for everyone or for every circumstance.

People with high blood pressure or kidney disease should avoid them. Anyone who eats a balanced diet and doesn’t engage in intense, endurance sports probably gets enough sodium to avoid heat cramps and other heat-related problems.

If you’re curious about salt tablets, or find that you’re prone to heat cramps and dehydrations when active, ask your doctor if this product may be appropriate for you.

Your doctor may recommend sports drinks rich in electrolytes, but if you want to avoid the sugar in those drinks, see if water and salt tablets will help you on those long runs or hot days doing yard work.

Slow Sodium – Patient Information Leaflet (PIL)

The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine.

Last updated on emc: 26 Jul 2022

View or print the patient leaflet as PDF

Print patient leaflet as text only

SLOW SODIUM TABLETS

Always take this medicine exactly as described in this leaflet or as your doctor or pharmacist has told you.

Keep this leaflet. You may need to read it again.
Ask your pharmacist if you need more information or advice.
If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet. See section 4.

1. What Slow Sodium tablets are and what they are used for

2. What you need to know before you take Slow Sodium tablets

3. How to take Slow Sodium tablets

4. Possible side effects

5. How to store Slow Sodium tablets

6. Contents of the pack and other information

Slow Sodium tablets contain the active substance sodium chloride (salt) in a special slow-release form. Slow Sodium tablets are used for the treatment and prevention of sodium chloride deficiency.

are allergic to sodium chloride or any of the ingredients of Slow Sodium tablets (listed in Section 6)
have fluid retention
have heart disease or failure
have aldosteronism (a condition where too much aldosterone [a hormone] is produced)
are having treatment to produce salt and water loss, usually if you have fluid retention or heart failure or have high blood pressure.

Talk to your doctor or pharmacist before taking Slow Sodium if you:

have a condition of the intestines, where narrowing may occur e.g. Crohn’s disease, diverticulitis or stricture (band) formation (usually after major abdominal surgery).
think you may have a problem drinking enough water.

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. In particular, Slow Sodium may affect medicines (e.g. furosemide, bumetanide, metolazone) used to treat high blood pressure particularly if you also have a kidney disorder.

It may still be all right for you to be given Slow Sodium tablets and your doctor will be able to decide what is suitable for you.

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Slow Sodium tablets should have no effect on your ability to drive and use machines.

Always take this medicine exactly as described in this leaflet or as your doctor has told you. Check with your doctor or pharmacist if you are not sure.

The recommended dose is:

Adults:

To prevent sodium chloride deficiency: 4-8 tablets per day.

For cases of severe salt loss: Up to 20 tablets per day.

To control muscle cramps during haemodialysis (treatment with a kidney machine): 10-16 tablets.

Use in children and adolescents:

The dose is adjusted to the child’s needs.

The tablets should be swallowed whole with water (about 70ml per tablet) and not chewed.

Tell your doctor straight away or go to the nearest casualty department immediately, taking the tablet container with you.

If you miss a dose, take one as soon as you can. If you have missed several doses tell your doctor. Do not take a double dose to make up for a forgotten dose.

If you have any further questions on the use of this medicine, ask your doctor or pharmacist.

No side effects have been reported at the recommended doses.

If you get any side effects talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet. You can also report side effects directly via the yellow card scheme at www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine.

Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the label after EXP. The expiry date refers to the last day of that month. Do not store above 30°C. Store in the original bottle in order to protect from moisture.

Do not throw away any medicines via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help protect the environment.

The active substance is sodium chloride.

Each tablet contains the equivalent of 600mg of sodium chloride.

The other ingredients are: cetostearyl alcohol, gelatin, magnesium stearate, hypromellose phthalate (E464), hydroxypropyl cellulose (E463), talc and titanium dioxide (E171).

The tablets are round, white and polished.

They are available in containers of 100 tablets.

ALTURIX Ltd.
287 Upper Fourth Street
Milton Keynes
MK9 1EH
U.K.

Kymos S.L.
Ronda de Can Fatjó, 7B
Parque Technológico del Vallès
Cerdanyola del Vallès 08290
Barcelona
Spain

Elara Pharmaservices Limited
Iron Farm
7 Grimesgate
Diseworth
DE74 2QD
United Kingdom

This leaflet was last revised in July 2021.

PL 44490/0004

solution for infusion, solution for injection, nasal spray, solvent for the preparation of dosage forms for injection, 0.9%, 0.65%, 0.9%, 0.9%

Sodium chloride (solution for infusion, 0.9%), instructions for medical use RU No. Р N003758/01

Date of last change: 03. 08.2021

Active substance
ATX
Nosological classification (ICD-10)
Pharmacological group
Dosage form
Compound
Description of the dosage form
Pharmacokinetics
Pharmacodynamics
Indications
Contraindications
Use during pregnancy and lactation
Dosage and administration
Side effects
Interaction
Overdose
special instructions
Release form
Terms of dispensing from pharmacies
Storage conditions
Best before date
Order in Moscow pharmacies
Reviews

Active ingredient

Sodium chloride

ATX

B05CB01 Sodium chloride

Nosological classification (ICD-10)

ICD-10 code list

A00. 9 Cholera, unspecified
E86 Decreased fluid volume [hypovolemia]
E87.0 Hyperosmolarity and hypernatremia
K30 Dyspepsia
K56.6 Other and unspecified ileus
K59.1 Functional diarrhea
R11 Nausea and vomiting
T14. 1 Open wound of body area unspecified
T30 Thermal and chemical burns, unspecified
T65 Toxic effects of other and unspecified substances
X49Accidental poisoning and exposure to other and unspecified chemicals and poisons

Pharmacological group

Regulators of water-electrolyte balance and acid-base balance

Dosage form

Solution
for infusions.

Composition

Active ingredient:

Sodium
chloride – 9.0 g

Excipient:

Water
for injections – up to 1.0 l.

Ionic
composition:

B
1 l of the preparation contains:

Iona
sodium (Na ⁺) – 154 mmol

Iona
chlorine (Cl ^– )
– 154 mmol

Theoretical
osmolarity 308 mOsmol/l.

Description of dosage form

Transparent
colorless liquid.

Pharmacokinetics

Concentration
sodium ions – 142 mmol / l (plasma) and 145 mmol / l (interstitial
liquid), chloride concentration – 101 mmol / l (interstitial fluid).
Excreted by the kidneys.

Pharmacodynamics

Plasma substitute
means. It has a detoxifying and rehydrating effect. Replenishes
deficiency of sodium ions in various pathological conditions. 0.9% solution
sodium chloride is isotonic to human plasma and is therefore rapidly eliminated from
vascular bed, only temporarily increasing the volume of circulating blood
(effectiveness in blood loss and shock is insufficient).

Indications

Plasma isotonic
fluid replacement, hypochloremic alkalosis, hyponatremia with dehydration,
intoxication, dissolution and dilution of parenterally administered medicinal
preparations (as a stock solution).

Contraindications

Hypernatremia,
hyperchloremia, hypokalemia; extracellular hyperhydration; circulatory
disorders associated with the risk of developing cerebral and pulmonary edema; edema
brain; pulmonary edema; decompensated heart failure;
conditions that can cause sodium retention, hypervolemia, and edema
(central and peripheral), such as: primary aldosteronism,
caused, for example, by arterial hypertension, congestive heart
failure, liver disease (including cirrhosis), kidney disease (including
arterial stenosis and nephrosclerosis), preeclampsia; concomitant appointment
glucocorticosteroids in high doses; contraindications to added to the solution
drugs.

With caution

Chronic
heart failure, chronic renal failure (oligo-
, anuria), acidosis, arterial hypertension, peripheral edema, toxicosis
pregnant.

Use in pregnancy and lactation

Data
on the use of the drug during pregnancy and during breastfeeding
not enough. May be used during pregnancy and lactation
breastfeeding when the expected benefit to the mother exceeds
possible risk of complications.

Dosage and administration

Information for healthcare professionals only.
Are you a healthcare professional?

IV
(drip). Doses, speed and duration of application are selected
individually depending on the indication for use, age, body weight,
the patient’s condition and concomitant therapy, as well as the effectiveness of treatment with
in terms of general symptoms and laboratory findings.

Before
by introducing the solution is heated to 36–38 °C. The dose is determined depending on
from the loss of body fluid, sodium and chlorine ions, and on average is
1000 ml / day as an intravenous continuous drip infusion with
injection rate up to 180 drops/minute. With large fluid losses and severe
intoxication, it is possible to administer up to 3000 ml / day. Insertion rate
540 ml / h, if necessary, the rate of administration is increased. Children with
a pronounced decrease in blood pressure against the background of dehydration (before determining
laboratory parameters, namely: determination of sodium, potassium, chlorine in plasma
blood and urine; study of acid-base balance; definition
residual nitrogen and plasma creatinine concentration) is administered
20–30 mg/kg. In the future, the dosing regimen is adjusted depending on
from laboratory parameters. With prolonged administration of large doses 0.9% solution
sodium chloride should be monitored in blood plasma and urine.

Side effects

When used correctly, unwanted effects are unlikely. unwanted
reactions recorded during post-marketing use are grouped
by systems and organs in accordance with the MedDRA dictionary
and are listed below in descending order of their severity, without indicating the frequency
occurrence.

Circulatory side:

Acidosis,
hyperhydration, hypokalemia.

From the immune system:

Reactions
hypersensitivity or infusion reactions, including hypotension,
pyrexia, tremor, chills, urticaria, rash, itching.

General disorders and administration site disorders:

Reactions
at the injection site, such as erythema, hemorrhage/hematoma, burning sensation,
urticaria at the injection site; thrombosis or phlebitis at the injection site.

Other:

Fever,
infections at the injection site (in violation of the rules of antiseptics).

At
the use of the drug as a base solution (solvent) for other
drugs, the likelihood of side effects is determined by the properties of these
drugs. In this case, if adverse reactions occur, stop
administration of the solution, assess the patient’s condition, take adequate measures and maintain
the remaining solution for analysis, if necessary.

Interactions

Information for healthcare professionals only.
Are you a healthcare professional?

At
mixing with other drugs, visual control is necessary for
compatibility (may be chemical or therapeutic
incompatibility).

Compatible
with colloidal hemodynamic blood substitutes (mutual enhancement of the effect).

Overdose

Symptoms

Nausea,
vomiting, diarrhea, crampy abdominal pain, thirst, decreased salivary and
lacrimation, increased sweating, fever, tachycardia, increased arterial
pressure, renal failure, peripheral edema, pulmonary edema,
respiratory arrest, headache, dizziness, anxiety,
irritability, weakness, muscle cramps and rigidity, generalized
convulsions, coma and death. Excessive introduction of sodium chloride solution 0.9% Maybe
cause hypernatremia. Excessive intake of chloride in the body can
lead to hyperchloraemic acidosis. If a solution of sodium chloride 0.9%
used as a stock solution for the dilution and transport of other
drugs, symptoms and complaints of overdose are most often associated with
properties of the drugs added to the solution. In case of unintentional
excessive administration of the solution, treatment should be stopped and the condition assessed
patient.

Treatment

Symptomatic.

Special instructions

during any infusion, the patient’s condition should be monitored,
clinical biological parameters, it is especially important to evaluate electrolytes
blood plasma. In the body of children, due to the immaturity of kidney function,
slow sodium excretion. Therefore, in these patients, repeated infusions
should be carried out only after determining the concentration of sodium in the blood plasma.
If hypersensitivity reactions or infusion reactions occur, infusion
stop immediately and take the necessary therapeutic measures to
testimony. Depending on the volume and rate of infusion against the background of intravenous
administration of the drug, there is a risk of developing hypervolemia and (or) overload
solutes and electrolyte imbalances. In patients with
renal insufficiency, the drug should be used with extreme caution or
do not apply at all. The use of the drug in such patients can lead to
sodium retention. Use only a clear solution, without visible inclusions and,
if the packaging is not damaged. Enter immediately after connecting to
infusion system. The solution should be administered using a sterile
equipment in compliance with the rules of asepsis and antisepsis. To avoid
air entering the infusion system, it should be filled with a solution,
releasing the residual air from the container completely. Like for everyone
parenteral solutions, the compatibility of the added substances with the solution should
determined before dissolution. Should not be used with sodium solution
chloride 0.9% drugs known to be incompatible with it. Define
compatibility of added medicinal substances with sodium chloride solution
0.9%, should the doctor, after checking for possible discoloration and / or the appearance of a precipitate,
insoluble complexes or crystals. Before adding, you must
determine if the added substance is soluble and stable in water
at pH level,
as in a solution of sodium chloride 0. 9%. When adding the drug
determine the isotonicity of the resulting solution before administration. Before adding to
the solution of drugs must be thoroughly mixed in compliance with the rules
asepsis. The prepared solution should be administered immediately after preparation, not
keep! Each unused dose should be discarded.

Effects on ability to drive
vehicles, mechanisms

Clinical
studies to evaluate the effect of the drug on the ability to manage
vehicles and mechanisms were not carried out.

Presentation

Solution
for infusions 0.9% at 50, 100, 150, 200, 250, 300, 350, 400, 450, 500, 750, 800,
1000, 1250, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500 or
6000 ml in self-draining polymer containers for infusion solutions
single use PVC film with one or two ports
for infusion solutions or from a transparent multilayer polyolefin film
(without PVC) with one or two separate polypropylene
injection ports type SFC,
equipped with injection unit liners made of polyisoprene or
thermoplastic elastomer, hermetically sealed polypropylene caps,
providing control of the “first opening”, or 1500, 2000, 2500, 3000,
3500, 4000, 4500, 5000, 5500 or 6000 ml in polyolefin bags for
spill and storage of infusion solutions.

By
25, 50, 100, 150, 200, 250, 300, 350, 400, 450 or 500 ml vials
polymer with a sealed neck with a polymer cap one-port or two
port. Containers, bags and vials withstand steam-water sterilization
mixture at a temperature of (120 ⁺² ) °C. Every
the container has a loop for hanging, a reserve volume, for additional
the introduction of the drug at least 35% of the volume of the container, the possibility
using a device for infusion of blood substitutes and infusion solutions
single use sterile (hereinafter referred to as the infusion device).
Containers and vials are compatible with the drug mixing device
means of single use sterile (hereinafter referred to as the cannula).

On
a polymer bottle is glued with a label made of label paper or writing paper or
self-adhesive label or self-adhesive label with hanging loop.

Each
container, pouch or vial is packed in a secondary pouch made from
polypropylene or high density polyethylene. Containers, packages or
vials in the secondary packaging are placed in a shipping container (boxes made of
corrugated cardboard). Instructions for
medical use of the medicinal product in an amount equal to
the number of containers.

For hospitals

By
90, 50 or 48 50 ml containers, 68, 44 or 35 containers each
100 ml, 46 or 36 containers 200 ml, 36,
34, 28 or 24 250 ml containers, 28 or 20 containers each
300 ml, 24 or 18 containers of 350 ml, each
22 or 16 400 ml containers, 22 or 14 containers each
with a capacity of 450 ml, 20, 18 or 12 containers with a capacity of 500 ml, each
12 or 8 750 ml containers, 12, 10 or 7 containers each
with a capacity of 800 ml, 12, 9or 6 containers with a capacity of 1000 ml, 6 each
or 5 containers of 1250 ml, 4 containers or bags
with a capacity of 1500 ml, 4 or 3 containers or bags with a capacity of 2500,
3000 ml, 2 or 1 container or bag with a capacity of 3500, 4000, 4500,
5000 ml, 1 container or bag with a capacity of 5500 or 6000 ml
placed in secondary packaging (corrugated cardboard boxes).

From
1 to 90 50, 300, 350, 400, 450, 500, 750, 800, 1000, 1250, 1500, 2000, 2500,
3000, 3500, 4000, 4500, 5000, 5500 or 6000 ml polyolefin film
placed in secondary packaging (corrugated cardboard boxes). In a box with
containers enclose instructions for the medical use of the drug
drug in an amount equal to the number of containers.

By
30 containers with a capacity of 100 ml, 22 containers with a capacity
200 ml, 20 containers each 250 ml, 15 containers each
400 ml, 12 containers of 500 ml or 7
containers with a capacity of 1000 ml made of polyolefin film with an equal
the number of infusion devices with a Luer connection cone or
Luer-Lock, each in a sterile package, is placed in a secondary package
(corrugated cardboard boxes). The box contains instructions for medical
the use of the medicinal product and instructions for use of the device for
injections with a connecting cone “Luer” or “Luer-Lock” in the amount,
the same number of containers.

By
30 containers with a capacity of 100 ml, 22 containers with a capacity of 200 ml,
20 containers each with a capacity of 250 ml, 15 containers each with a capacity
400 ml, 12 x 500 ml containers or 7 x containers
1000 ml polyolefin film with equal number of cannulas
“MP-mix” or “MP-minimix”, each in a sterile package, is placed in
secondary packaging (corrugated cardboard boxes). Putting in a box
instructions for medical use of the medicinal product and instructions for
the use of cannula “MP-mix” or “MP-minimix” in an amount equal to the amount
containers.

By
30 containers with a capacity of 100 ml, 22 containers with a capacity
200 ml, 20 containers each 250 ml, 15 containers each
400 ml, 12 containers of 500 ml or 7
containers with a capacity of 1000 ml made of polyolefin film with an equal
the number of infusion devices with a Luer connection cone or
“Luer-Lock” (each in a sterile package) and with an equal number of cannulas
“MP-mix” or “MP-minimix” (each in a sterile package) is placed in a secondary
packaging (corrugated cardboard boxes). The box contains instructions for
medical use of the medicinal product, instructions for use
infusion devices with a Luer or Luer-Lock cone and
instructions for use of the cannula “MP-mix” or “MP-minimix” in the amount,
the same number of containers.

From
1 to 48 polymer vials of 25, 50, 100, 150, 200, 250, 300, 350, 400, 450
or 500 ml of the drug with an equal number of instructions for medical use
medicinal product is placed in secondary packaging – boxes made of
corrugated cardboard with gratings – “nests” made of cardboard. Can in a box
to invest a ring suspension system (CPS) for a polymer bottle in
quantity equal to the number of polymer vials.

From
1 to 48 polymer vials of 25, 50, 100, 150, 200, 250, 300, 350, 400, 450
or 500 ml of the drug with an equal number of infusion devices with
connecting cone “Luer” or “Luer-Lock”, each in a sterile
packaging, placed in secondary packaging (corrugated cardboard boxes). IN
the box contains instructions for the medical use of the medicinal product
and instructions for use of an infusion device with a connecting cone
“Luer” or “Luer-Lokk” in an amount equal to the number of vials.

From
1 to 48 polymer vials of 25, 50, 100, 150, 200, 250, 300, 350, 400, 450
or 500 ml of the drug with an equal number of cannulas “MP-mix” or “MP-maximix”,
each in a sterile package, placed in secondary packaging (boxes made of
corrugated cardboard). The box contains instructions for medical
the use of the medicinal product and instructions for the use of the cannula “MP-mix”
or “MP-maximiks” in an amount equal to the number of vials.

From
1 to 48 polymer vials of 25, 50, 100, 150, 200, 250, 300, 350, 400, 450
or 500 ml of the drug with an equal number of infusion devices with
connecting cone “Luer” or “Luer-Lock” (each in a sterile
packaging) and with an equal number of cannulas “MP-mix” or “MP-maximix”
(each in a sterile package) are placed in secondary packaging (boxes made of
corrugated cardboard). The box contains instructions for medical
the use of the medicinal product, instructions for use of the device for
Luer or Luer Lock infusions and instructions
on the use of the cannula “MP-mix” or “MP-maximix” in an amount equal to
the number of vials.

Terms of dispensing from pharmacies

To
prescription.

Storage conditions

B
in a place inaccessible to children at a temperature not exceeding 25 ° C. Allowed
freezing during transportation.

Expiration date

3
years – for the drug in polymer containers made of polyvinyl chloride film, in
bags for intravenous infusions or in polymer vials.

4
years – for the drug in containers made of polyolefin film.

Not
use after the expiration date.

Update date: 06/23/2023

The information provided on the prices of drugs is not an offer to sell or buy goods.

The information is intended solely for comparing prices in stationary pharmacies operating in
in accordance with Article 55 of the Federal Law “On the Circulation of Medicines” dated April 12, 2010 No. 61-FZ.

solution for infusion, solution for injection, nasal spray, solvent for the preparation of dosage forms for injection, 0.

9%, 0.65%, 0.9%, 0.9%

Sodium chloride (solution for infusion, 0.9%) 8.2021

Active substance
ATX
Nosological classification (ICD-10)
Pharmacological group
Dosage form
Compound
Description of the dosage form
Pharmacokinetics
Pharmacodynamics
Indications
Contraindications
Use during pregnancy and lactation
Dosage and administration
Side effects
Interaction
Overdose
special instructions
Release form
Terms of dispensing from pharmacies
Storage conditions
Best before date
Order in Moscow pharmacies
Reviews

Active ingredient

Sodium chloride

ATX

B05CB01 Sodium chloride

Nosological classification (ICD-10)

ICD-10 code list

A00. 9 Cholera, unspecified
E86 Decreased fluid volume [hypovolemia]
E87.0 Hyperosmolarity and hypernatremia
K30 Dyspepsia
K56.6 Other and unspecified ileus
K59.1 Functional diarrhea
R11 Nausea and vomiting
T14. 1 Open wound of body area unspecified
T30 Thermal and chemical burns, unspecified
T65 Toxic effects of other and unspecified substances
X49Accidental poisoning and exposure to other and unspecified chemicals and poisons

Pharmacological group

Regulators of water-electrolyte balance and acid-base balance

Dosage form

Solution
for infusions.

Composition

Active ingredient:

Sodium
chloride – 9.0 g

Excipient:

Water
for injections – up to 1.0 l.

Ionic
composition:

B
1 l of the preparation contains:

Iona
sodium (Na ⁺) – 154 mmol

Iona
chlorine (Cl ^– )
– 154 mmol

Theoretical
osmolarity 308 mOsmol/l.

Description of dosage form

Transparent
colorless liquid.

Pharmacokinetics

Concentration
sodium ions – 142 mmol / l (plasma) and 145 mmol / l (interstitial
liquid), chloride concentration – 101 mmol / l (interstitial fluid).
Excreted by the kidneys.

Pharmacodynamics

Indications

Contraindications

With caution

Chronic
heart failure, chronic renal failure (oligo-
, anuria), acidosis, arterial hypertension, peripheral edema, toxicosis
pregnant.

Use in pregnancy and lactation

Dosage and administration

Information for healthcare professionals only.
Are you a healthcare professional?

Side effects

Circulatory side:

Acidosis,
hyperhydration, hypokalemia.

From the immune system:

Reactions
hypersensitivity or infusion reactions, including hypotension,
pyrexia, tremor, chills, urticaria, rash, itching.

General disorders and administration site disorders:

Reactions
at the injection site, such as erythema, hemorrhage/hematoma, burning sensation,
urticaria at the injection site; thrombosis or phlebitis at the injection site.

Other:

Fever,
infections at the injection site (in violation of the rules of antiseptics).

Interactions

Information for healthcare professionals only.
Are you a healthcare professional?

At
mixing with other drugs, visual control is necessary for
compatibility (may be chemical or therapeutic
incompatibility).

Compatible
with colloidal hemodynamic blood substitutes (mutual enhancement of the effect).

Overdose

Symptoms

Treatment

Symptomatic.

Special instructions

Effects on ability to drive
vehicles, mechanisms

Clinical
studies to evaluate the effect of the drug on the ability to manage
vehicles and mechanisms were not carried out.

Presentation

On
a polymer bottle is glued with a label made of label paper or writing paper or
self-adhesive label or self-adhesive label with hanging loop.

For hospitals

By
30 containers with a capacity of 100 ml, 22 containers with a capacity
200 ml, 20 containers each 250 ml, 15 containers each
400 ml, 12 containers of 500 ml or 7
containers with a capacity of 1000 ml made of polyolefin film with an equal
the number of infusion devices with a Luer connection cone or
“Luer-Lock” (each in a sterile package) and with an equal number of cannulas
“MP-mix” or “MP-minimix” (each in a sterile package) is placed in a secondary
packaging (corrugated cardboard boxes). The box contains instructions for
medical use of the medicinal product, instructions for use
infusion devices with a Luer or Luer-Lock cone and
instructions for use of the cannula “MP-mix” or “MP-minimix” in the amount,
the same number of containers.