What are the primary uses of Vitamin B6. How does Vitamin B6 affect various health conditions. What are the potential side effects and precautions associated with Vitamin B6 supplementation. How does Vitamin B6 interact with other medications and supplements.

The Vital Role of Vitamin B6 in Human Health

Vitamin B6, also known as pyridoxine, is a crucial nutrient that plays a significant role in numerous bodily functions. This water-soluble vitamin exists in several forms, including pyridoxine, pyridoxal, and pyridoxamine. Found naturally in various foods and synthesized in laboratories, Vitamin B6 is essential for the proper metabolism of sugars, fats, and proteins.

Beyond its metabolic functions, Vitamin B6 is integral to the development and maintenance of the brain, nervous system, skin, and numerous other body parts. Its importance in human health cannot be overstated, as it contributes to over 100 enzyme reactions in the body.

Natural Sources of Vitamin B6

• Cereals (especially fortified varieties)
• Legumes (beans, lentils, chickpeas)
• Eggs
• Poultry
• Fish
• Potatoes
• Non-citrus fruits

While Vitamin B6 is available in many foods, it’s often included in vitamin B complex supplements, ensuring a balanced intake of all essential B vitamins.

Proven Medical Applications of Vitamin B6

The efficacy of Vitamin B6 in treating certain medical conditions is well-established through scientific research. Its applications range from treating rare genetic disorders to managing common health issues.

Pyridoxine-Dependent Epilepsy

Can Vitamin B6 help control seizures in infants? In cases of pyridoxine-dependent epilepsy, a rare seizure disorder, intravenous administration of Vitamin B6 has proven effective in controlling seizures. This treatment, however, must be administered by healthcare professionals due to its intravenous nature.

Sideroblastic Anemia

Sideroblastic anemia, a condition characterized by the production of abnormal red blood cells that accumulate iron, can be effectively treated with oral Vitamin B6 supplementation. This is particularly true for the inherited form of this anemia.

Vitamin B6 Deficiency

Oral administration of Vitamin B6 is highly effective in both preventing and treating Vitamin B6 deficiency. This underscores the importance of maintaining adequate levels of this vital nutrient in the body.

Potential Benefits of Vitamin B6 Supplementation

Beyond its proven medical applications, Vitamin B6 shows promise in addressing several other health concerns. While more research is needed to conclusively establish its efficacy in these areas, current evidence suggests potential benefits.

Hyperhomocysteinemia

How does Vitamin B6 affect homocysteine levels? Taking Vitamin B6 orally, often in combination with folic acid, has shown effectiveness in treating high homocysteine levels in the blood. This is significant as elevated homocysteine levels are associated with increased risk of cardiovascular diseases.

Hyperprolactinemia

In males experiencing high levels of prolactin (hyperprolactinemia) due to antipsychotic medications, oral Vitamin B6 supplementation has demonstrated the ability to reduce prolactin levels.

Kidney Stones

Vitamin B6, either alone or in combination with magnesium, may decrease the risk of kidney stone formation. This effect is particularly notable in individuals with inherited conditions predisposing them to kidney stones.

Morning Sickness

For pregnant women experiencing mild to moderate nausea and vomiting, Vitamin B6 supplementation has shown to improve symptoms. In cases where Vitamin B6 alone is insufficient, a combination of Vitamin B6 and doxylamine is recommended.

Premenstrual Syndrome (PMS)

Oral Vitamin B6 supplementation appears to alleviate PMS symptoms, including breast pain. It’s important to note that the lowest effective dose should be used, as higher doses may increase the risk of side effects without providing additional benefits.

Conditions Where Vitamin B6 May Not Be Effective

While Vitamin B6 shows promise in numerous areas, research indicates it may not be effective for certain conditions. Understanding these limitations is crucial for making informed decisions about supplementation.

• Age-related cognitive decline
• Alzheimer’s disease prevention
• Carpal tunnel syndrome
• Cataract prevention
• Chemotherapy-induced acral erythema
• Colorectal adenoma prevention
• Eclampsia and pre-eclampsia
• Osteoporosis
• Preterm birth prevention

In these cases, Vitamin B6 supplementation has not shown significant benefits, and in some instances, may even have adverse effects. For example, high-dose Vitamin B6 in combination with folic acid and Vitamin B12 may increase the risk of requiring cataract removal.

Safety Profile and Potential Side Effects of Vitamin B6

When considering Vitamin B6 supplementation, it’s essential to understand its safety profile and potential side effects. While generally considered safe when used appropriately, there are important considerations to keep in mind.

General Safety

Is Vitamin B6 safe for general use? Vitamin B6 is likely safe when taken orally in appropriate doses. Daily intake of 100 mg or less is generally considered safe for most people. However, as with any supplement, it’s advisable to consult with a healthcare provider before starting a new regimen.

Potential Side Effects

While rare, some individuals may experience side effects from Vitamin B6 supplementation, especially at higher doses. These may include:

• Nausea
• Vomiting
• Stomach pain
• Loss of appetite
• Headache
• Tingling or numbness in extremities (at very high doses)

It’s important to note that these side effects are typically associated with doses significantly higher than the recommended daily allowance.

Precautions and Special Considerations

While Vitamin B6 is generally safe for most people, certain groups should exercise caution or seek medical advice before supplementing.

Pregnancy and Breastfeeding

Is Vitamin B6 safe during pregnancy and breastfeeding? Vitamin B6 is likely safe when taken in recommended amounts during pregnancy and breastfeeding. However, higher doses should be avoided unless prescribed by a healthcare provider.

Individuals with Specific Health Conditions

People with certain health conditions should consult their healthcare provider before taking Vitamin B6 supplements. These conditions include:

• Kidney disease
• Liver disease
• Seizure disorders
• Parkinson’s disease

Interactions with Medications

Vitamin B6 can interact with various medications. It’s crucial to inform your healthcare provider about all medications and supplements you’re taking. Some medications that may interact with Vitamin B6 include:

• Certain antibiotics
• Antiepileptic drugs
• Levodopa (used for Parkinson’s disease)
• Certain chemotherapy drugs

Dosage Recommendations and Guidelines

Determining the appropriate dosage of Vitamin B6 depends on various factors, including age, sex, and specific health conditions. The Recommended Dietary Allowance (RDA) for Vitamin B6 varies across different life stages.

General RDA for Vitamin B6

• Infants 0-6 months: 0.1 mg/day
• Infants 7-12 months: 0.3 mg/day
• Children 1-3 years: 0.5 mg/day
• Children 4-8 years: 0.6 mg/day
• Children 9-13 years: 1.0 mg/day
• Males 14-50 years: 1.3 mg/day
• Males 51+ years: 1.7 mg/day
• Females 14-18 years: 1.2 mg/day
• Females 19-50 years: 1.3 mg/day
• Females 51+ years: 1.5 mg/day
• Pregnant women: 1.9 mg/day
• Breastfeeding women: 2.0 mg/day

For specific conditions, higher doses may be recommended under medical supervision. For instance, doses of 50-100 mg daily have been used for treating certain types of anemia or managing PMS symptoms.

Upper Limit

The tolerable upper intake level for adults is set at 100 mg per day. Exceeding this limit may increase the risk of adverse effects, particularly neurological symptoms.

When considering Vitamin B6 supplementation, it’s crucial to account for dietary intake. Many people can meet their Vitamin B6 needs through a balanced diet rich in B6-containing foods. Supplementation should be considered only when dietary intake is insufficient or when recommended by a healthcare provider for specific health conditions.

Current Research and Future Prospects

The field of Vitamin B6 research is dynamic, with ongoing studies exploring its potential in various health areas. While some applications of Vitamin B6 are well-established, researchers continue to investigate its role in preventing and treating a wide range of conditions.

Emerging Areas of Research

• Cognitive function and mental health
• Cardiovascular health
• Cancer prevention
• Immune system function
• Diabetes management

These areas of research hold promise for expanding our understanding of Vitamin B6’s role in human health. However, it’s important to note that many of these potential applications require further study before definitive conclusions can be drawn.

Genetic Factors and Vitamin B6 Metabolism

Recent advances in genetic research have highlighted the role of individual genetic variations in Vitamin B6 metabolism. These findings suggest that personalized approaches to Vitamin B6 supplementation may be beneficial in the future, taking into account an individual’s genetic makeup and specific health needs.

As research progresses, our understanding of Vitamin B6’s role in human health continues to evolve. This ongoing exploration may lead to new applications and more targeted use of Vitamin B6 in both preventive health strategies and medical treatments.

In conclusion, Vitamin B6 stands as a vital nutrient with a wide range of established and potential health benefits. From its crucial role in metabolism to its applications in treating specific medical conditions, Vitamin B6 continues to be an important focus of nutritional and medical research. As with any supplement, it’s essential to approach Vitamin B6 supplementation with an informed perspective, considering individual health needs and consulting with healthcare professionals when necessary. The future of Vitamin B6 research holds exciting possibilities for enhancing our understanding of this essential nutrient and its impact on human health.

Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews

Overview

Vitamin B6 is a type of B vitamin. Pyridoxine, pyridoxal, and pyridoxamine are all forms of vitamin B6. It’s found in certain foods and also made in a lab.

Vitamin B6 is needed for the proper function of sugars, fats, and proteins in the body. It’s also necessary for the development of the brain, nerves, skin, and many other parts of the body. It’s found in cereals, legumes, and eggs, and often used with other B vitamins in vitamin B complex products.

People commonly use vitamin B6 for preventing and treating vitamin B6 deficiency. It is also used for heart disease, premenstrual syndrome (PMS), depression, morning sickness, Alzheimer disease, menstrual cramps, diabetes, and many other conditions, but there is no good scientific evidence to support many of these other uses.

Uses & Effectiveness ?

Effective for

• A rare seizure disorder that requires vitamin B6. Giving infants vitamin B6 by IV controls seizures caused by a condition called pyridoxine-dependent epilepsy. IV products can only be given by a healthcare provider.
• A condition in which the body makes abnormal red blood cells that build up iron (sideroblastic anemia). Taking vitamin B6 by mouth is effective for treating an inherited type of anemia called sideroblastic anemia.
• Vitamin B6 deficiency. Taking vitamin B6 by mouth is effective for preventing and treating vitamin B6 deficiency.

Likely Effective for

• High levels of homocysteine in the blood (hyperhomocysteinemia). Taking vitamin B6 by mouth, usually with folic acid, is effective for treating high homocysteine levels in the blood.

Possibly Effective for

• High levels of a hormone called prolactin (hyperprolactinemia) caused by antipsychotic drugs. Taking vitamin B6 by mouth reduces levels of prolactin in males with this condition.
• Kidney stones. Taking vitamin B6 by mouth, alone or along with magnesium, can decrease the risk of kidney stones, especially in people with an inherited condition that causes kidney stones.
• Morning sickness. Taking vitamin B6 by mouth improves symptoms of mild to moderate nausea and vomiting during pregnancy. Vitamin B6 plus the drug doxylamine is recommended for those who don’t get better when taking vitamin B6 alone.
• Premenstrual syndrome (PMS). Taking vitamin B6 (pyridoxine) by mouth seems to improve PMS symptoms including breast pain. The lowest effective dose should be used. Higher doses will increase the chance of side effects and aren’t likely to increase benefits.

Possibly Ineffective for

• Decline in memory and thinking skills that occurs normally with age. Taking vitamin B6 by mouth doesn’t improve mental function in elderly people.
• Alzheimer disease. Taking vitamin B6 supplements by mouth or eating large amounts of vitamin B6 in the diet doesn’t seem to reduce the risk for Alzheimer disease.
• Carpal tunnel syndrome. Taking vitamin B6 by mouth doesn’t seem to reduce symptoms of carpal tunnel syndrome.
• Cataracts. Taking vitamin B6 by mouth, together with folic acid and vitamin B12, doesn’t prevent cataracts. It might even increase the risk of needing to have cataracts removed.
• An adverse skin reaction caused by cancer drug treatment (chemotherapy-induced acral erythema). Taking vitamin B6 by mouth doesn’t seem to prevent this skin reaction in people treated with cancer drugs. Vitamin B6 might also reduce how well certain cancer drugs work.
• Non-cancerous growths in the large intestine and rectum (colorectal adenoma). Taking a combination of folic acid, vitamin B6, and vitamin B12 by mouth doesn’t reduce the risk of developing colorectal polyps.
• Seizures in people with high blood pressure during pregnancy (eclampsia). Taking vitamin B6 by mouth or as a shot doesn’t seem to reduce the risk of seizures during pregnancy. Vitamin B6 shots can only be given by a healthcare provider.
• Weak and brittle bones (osteoporosis). Taking a combination of folic acid, vitamin B6, and vitamin B12 by mouth doesn’t prevent broken bones in people with osteoporosis.
• A pregnancy complication marked by high blood pressure and protein in the urine (pre-eclampsia). Taking vitamin B6 by mouth or as a shot doesn’t seem to reduce the risk of pre-eclampsia. Vitamin B6 shots can only be given by a healthcare provider.
• Preterm birth. Taking vitamin B6 by mouth or as a shot doesn’t seem to reduce the risk of preterm birth. Vitamin B6 shots can only be given by a healthcare provider.

There is interest in using vitamin B6 for a number of other purposes, but there isn’t enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: Vitamin B6 is likely safe when used appropriately. Taking vitamin B6 in doses of 100 mg daily or less is generally considered to be safe. Vitamin B6 is possibly safe when taken in doses of 101-200 mg daily. In some people, vitamin B6 might cause nausea, stomach pain, loss of appetite, headache, and other side effects. Vitamin B6 is possibly unsafe when taken in doses of 500 mg or more daily. High doses of vitamin B6, especially 1000 mg or more daily, might cause brain and nerve problems.

Special Precautions and Warnings

When taken by mouth: Vitamin B6 is likely safe when used appropriately. Taking vitamin B6 in doses of 100 mg daily or less is generally considered to be safe. Vitamin B6 is possibly safe when taken in doses of 101-200 mg daily. In some people, vitamin B6 might cause nausea, stomach pain, loss of appetite, headache, and other side effects. Vitamin B6 is possibly unsafe when taken in doses of 500 mg or more daily. High doses of vitamin B6, especially 1000 mg or more daily, might cause brain and nerve problems. Pregnancy: Vitamin B6 is likely safe when taken by mouth, appropriately. It’s sometimes used to control morning sickness, but should only be done so under the supervision of a healthcare provider. Taking high doses is possibly unsafe. High doses might cause newborns to have seizures.

Breast-feeding: Vitamin B6 is likely safe when taken in doses of 2 mg by mouth daily. Avoid using higher amounts. There isn’t enough reliable information to know if taking higher doses of vitamin B6 is safe when breast-feeding.

Post-surgical stent placement. Avoid using a combination of vitamin B6, folate, and vitamin B12 after receiving a coronary stent. This combination may increase the risk of blood vessel narrowing.

Weight loss surgery. Taking a vitamin B6 supplement is not needed for people that have had weight loss surgery. Taking too much might increase the chance of side effects such as nausea, vomiting, and browning skin.

Interactions ?

Major Interaction

Do not take this combination

• Vitamin B6 might increase how quickly the body breaks down phenytoin. Taking vitamin B6 along with phenytoin might decrease the effects of phenytoin and increase the risk of seizures. Do not take large doses of vitamin B6 if you are taking phenytoin.

Moderate Interaction

Be cautious with this combination

• Amiodarone might increase sensitivity to sunlight. Taking vitamin B6 along with amiodarone might increase the chances of sunburn, blistering, or rashes on areas of skin exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.

• Vitamin B6 might increase how quickly the body breaks down phenobarbital. This could decrease the effects of phenobarbital.

• Vitamin B6 might lower blood pressure. Taking vitamin B6 along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Minor Interaction

Be watchful with this combination

• Vitamin B6 can increase how quickly the body breaks down and gets rid of levodopa. But this is only a problem if you are taking levodopa alone. Most people take levodopa along with carbidopa. Carbidopa prevents this interaction from occurring. If you are taking levodopa without carbidopa, do not take vitamin B6.

Dosing

Vitamin B6 is an important nutrient. Cereal grains, legumes, vegetables, meat, and eggs are good sources of vitamin B6. The amount that should be consumed on a daily basis is called the recommended dietary allowance (RDA). For males, the RDA is 1.3 mg daily for those 19-50 years old, and 1.7 mg daily for those over 50 years. For females, the RDA is 1.3 mg daily for those 19-50 years old, and 1.5 mg daily for those over 50 years. While pregnant, the RDA is 1.9 mg daily. While breast-feeding, the RDA is 2 mg daily. In children, the RDA depends on age.

In supplements, vitamin B6 is often used alone and in products containing other B vitamins. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

9 Health Benefits of Vitamin B6 (Pyridoxine)

Vitamin B6, also known as pyridoxine, is a water-soluble vitamin that your body needs for several functions. It has health benefits for the body, including promoting brain health and improving mood.

It’s significant to protein, fat and carbohydrate metabolism and the creation of red blood cells and neurotransmitters (1).

Your body cannot produce vitamin B6, so you must obtain it from foods or supplements.

Most people get enough vitamin B6 through their diet, but certain populations may be at risk for deficiency.

Consuming adequate amounts of vitamin B6 is important for optimal health and may even prevent and treat chronic diseases (2).

Here are 9 health benefits of vitamin B6, backed by science.

1. May Improve Mood and Reduce Symptoms of Depression

Vitamin B6 plays an important role in mood regulation.

This is partly because this vitamin is necessary for creating neurotransmitters that regulate emotions, including serotonin, dopamine and gamma-aminobutyric acid (GABA) (3, 4, 5).

Vitamin B6 may also play a role in decreasing high blood levels of the amino acid homocysteine, which have been linked to depression and other psychiatric issues (6, 7).

Several studies have shown that depressive symptoms are associated with low blood levels and intakes of vitamin B6, especially in older adults who are at high risk for B vitamin deficiency (8, 9, 10).

One study in 250 older adults found that deficient blood levels of vitamin B6 doubled the likelihood of depression (9).

However, using vitamin B6 to prevent or treat depression has not been shown to be effective (11, 12).

A controlled two-year study in approximately 300 older men who did not have depression at the start found that those taking a supplement with B6, folate (B9) and B12 were not less likely to have depressive symptoms compared to the placebo group (12).

Summary Low
levels of vitamin B6 in older adults have been linked to depression, but
research has not shown that B6 is an effective treatment for mood disorders.

2. May Promote Brain Health and Reduce Alzheimer’s Risk

Vitamin B6 may play a role in improving brain function and preventing Alzheimer’s disease, but the research is conflicting.

On the one hand, B6 can decrease high homocysteine blood levels that may increase the risk of Alzheimer’s (13, 14, 15).

One study in 156 adults with high homocysteine levels and mild cognitive impairment found that taking high doses of B6, B12 and folate (B9) decreased homocysteine and reduced wasting in some regions of the brain that are vulnerable to Alzheimer’s (16).

However, it’s unclear if a decrease in homocysteine translates to improvements in brain function or a slower rate of cognitive impairment.

A randomized controlled trial in over 400 adults with mild to moderate Alzheimer’s found that high doses of B6, B12 and folate decreased homocysteine levels but did not slow decline in brain function compared to a placebo (17).

In addition, a review of 19 studies concluded that supplementing with B6, B12 and folate alone or in combination did not improve brain function or reduce the risk of Alzheimer’s (18).

More research that looks at the effect of vitamin B6 alone on homocysteine levels and brain function is needed to better understand the role of this vitamin in improving brain health.

Summary Vitamin
B6 may prevent a decline in brain function by decreasing homocysteine levels
that have been associated with Alzheimer’s disease and memory impairments. However,
studies have not proven the effectiveness of B6 in improving brain health.

3. May Prevent and Treat Anemia by Aiding Hemoglobin Production

Due to its role in hemoglobin production, vitamin B6 may be helpful in preventing and treating anemia caused by deficiency (19).

Hemoglobin is a protein that delivers oxygen to your cells. When you have low hemoglobin, your cells don’t get enough oxygen. As a result, you may develop anemia and feel weak or tired.

Studies have linked low levels of vitamin B6 with anemia, especially in pregnant women and women of childbearing age (20, 21).

However, vitamin B6 deficiency is thought to be rare in most healthy adults, so there is limited research on using B6 to treat anemia.

A case study in a 72-year-old woman with anemia due to low B6 found that treatment with the most active form of vitamin B6 improved symptoms (22).

Another study found that taking 75 mg of vitamin B6 daily during pregnancy decreased symptoms of anemia in 56 pregnant women who were unresponsive to treatment with iron (20).

More research is needed to understand the effectiveness of vitamin B6 in treating anemia in populations other than those at increased risk for B vitamin deficiency, such as pregnant women and older adults

Summary Not
getting enough vitamin B6 can lead to low hemoglobin and anemia, so
supplementing with this vitamin may prevent or treat these issues.

4. May Be Useful in Treating Symptoms of PMS

Vitamin B6 has been used to treat symptoms of premenstrual syndrome, or PMS, including anxiety, depression and irritability.

Researchers suspect that B6 helps with emotional symptoms related to PMS due to its role in creating neurotransmitters that regulate mood.

A three-month study in over 60 premenopausal women found that taking 50 mg of vitamin B6 daily improved PMS symptoms of depression, irritability and tiredness by 69% (23).

However, women who received a placebo also reported improved PMS symptoms, which suggests that the effectiveness of the vitamin B6 supplement may have been due in part to a placebo effect (23).

Another small study found that 50 mg of vitamin B6 along with 200 mg of magnesium per day significantly reduced PMS symptoms, including mood swings, irritability and anxiety, over the course of one menstrual cycle (24).

While these results are promising, they’re limited by small sample size and short duration. More research on the safety and effectiveness of vitamin B6 in improving PMS symptoms is needed before recommendations can be made (25).

Summary Some
research has indicated that high doses of vitamin B6 may be effective at
decreasing anxiety and other mood issues associated with PMS due to its role in
creating neurotransmitters.

5. May Help Treat Nausea During Pregnancy

Vitamin B6 has been used for decades to treat nausea and vomiting during pregnancy.

In fact, it’s an ingredient in Diclegis, a medication commonly used to treat morning sickness (26).

Researchers are not entirely sure why vitamin B6 helps with morning sickness, but it may be because adequate B6 plays several vital roles in ensuring a healthy pregnancy (27).

A study in 342 women in their first 17 weeks of pregnancy found that a daily supplement of 30 mg of vitamin B6 significantly reduced feelings of nausea after five days of treatment, compared to a placebo (28).

Another study compared the impact of ginger and vitamin B6 on reducing episodes of nausea and vomiting in 126 pregnant women. The results showed that taking 75 mg of B6 each day decreased nausea and vomiting symptoms by 31% after four days (29).

These studies suggest that vitamin B6 is effective in treating morning sickness even in durations of less than one week.

If you’re interested in taking B6 for morning sickness, speak with your doctor before starting any supplements.

Summary Vitamin
B6 supplements in doses of 30–75 mg a day have been used as an effective
treatment for nausea and vomiting during pregnancy.

6. May Prevent Clogged Arteries and Reduce Heart Disease Risk

Vitamin B6 may prevent clogged arteries and minimize heart disease risk.

Research shows that people with low blood levels of vitamin B6 have almost double the risk of getting heart disease compared to those with higher B6 levels (30).

This is likely due to the role of B6 in decreasing elevated homocysteine levels associated with several disease processes, including heart disease (31, 32, 33).

One study found that rats deficient in vitamin B6 had higher blood levels of cholesterol and developed lesions that could cause artery blockages after being exposed to homocysteine, compared to rats with adequate B6 levels (33).

Human research also shows a beneficial effect of B6 in preventing heart disease.

A randomized controlled trial in 158 healthy adults who had siblings with heart disease divided participants into two groups, one that received 250 mg of vitamin B6 and 5 mg of folic acid every day for two years and another that received a placebo (31).

The group that took B6 and folic acid had lower homocysteine levels and less abnormal heart tests during exercise than the placebo group, putting them at an overall lower risk of heart disease (31).

Summary Vitamin
B6 may help reduce high homocysteine levels that lead to narrowing of arteries.
This may minimize heart disease risk.

7. May Help Prevent Cancer

Getting enough vitamin B6 may lower your risk of developing certain types of cancer.

The reason why B6 may help prevent cancer is unclear, but researchers suspect that it’s related to its ability to fight inflammation that may contribute to cancer and other chronic conditions (34, 35).

A review of 12 studies found that both adequate dietary intake and blood levels of B6 were associated with lower risks of colorectal cancer. Individuals with the highest blood levels of B6 had an almost 50% lower risk of developing this type of cancer (36).

Research on vitamin B6 and breast cancer also shows an association between adequate blood levels of B6 and a decreased risk of the disease, especially in postmenopausal women (37).

However, other studies on vitamin B6 levels and cancer risk have found no association (38, 39).

More research that includes randomized trials and not merely observational studies is needed to assess the exact role of vitamin B6 in cancer prevention.

Summary Some
observational studies suggest a link between adequate dietary intake and blood
levels of vitamin B6 and a decreased risk of certain types of cancer, but more
research is needed.

8. May Promote Eye Health and Prevent Eye Diseases

Vitamin B6 may play a role in preventing eye diseases, especially a type of vision loss that affects older adults called age-related macular degeneration (AMD).

Studies have linked high blood levels of circulating homocysteine with an increased risk of AMD (40, 41).

Since vitamin B6 helps reduce elevated blood levels of homocysteine, getting enough B6 may lower your risk of this disease (42).

A seven-year study in over 5,400 female health professionals found that taking a daily supplement of vitamin B6, B12 and folic acid (B9) significantly reduced AMD risk by 35–40%, compared to a placebo (43).

While these results suggest that B6 may play a role in preventing AMD, it’s difficult to tell if B6 alone would offer the same benefits.

Research has also linked low blood levels of vitamin B6 to eye conditions that block veins that connect to the retina. A controlled study in over 500 people found that the lowest blood levels of B6 were significantly associated with retinal disorders (44).

Summary Vitamin
B6 supplements may reduce your risk of age-related macular degeneration (AMD).
Additionally, adequate blood levels of B6 may prevent issues that affect the
retina. However, more research is needed.

9. May Treat Inflammation Associated With Rheumatoid Arthritis

Vitamin B6 may help reduce symptoms associated with rheumatoid arthritis.

The high levels of inflammation in the body that result from rheumatoid arthritis may lead to low levels of vitamin B6 (45, 46).

However, it’s unclear if supplementing with B6 decreases inflammation in people with this condition.

A 30-day study in 36 adults with rheumatoid arthritis found that 50 mg of vitamin B6 daily corrected low blood levels of B6 but did not decrease the production of inflammatory molecules in the body (47).

On the other hand, a study in 43 adults with rheumatoid arthritis that took 5 mg of folic acid alone or 100 mg of vitamin B6 with 5 mg of folic acid daily showed that those who received B6 had significantly lower levels of pro-inflammatory molecules after 12 weeks (48).

The contradictory results of these studies may be due to the difference in vitamin B6 dose and study length.

While it appears that high doses of vitamin B6 supplements may provide anti-inflammatory benefits for people with rheumatoid arthritis over time, more research is needed.

Summary Inflammation
associated with rheumatoid arthritis may lower blood levels of vitamin B6.
Supplementing with high doses of B6 may help correct deficiencies and reduce
inflammation, but more research is needed to confirm these effects.

Vitamin B6 Food Sources and Supplements

You can get vitamin B6 from food or supplements.

The current recommended daily amount (RDA) for B6 is 1.3–1.7 mg for adults over 19. Most healthy adults can get this amount through a balanced diet that includes vitamin-B6-rich foods like turkey, chickpeas, tuna, salmon, potatoes and bananas (1).

Studies that highlight the use of vitamin B6 to prevent and treat health issues focus on supplements rather than food sources.

Doses of 30–250 mg of vitamin B6 per day have been used in research on PMS, morning sickness and heart disease (24, 28, 31).

These amounts of B6 are significantly higher than the RDA and sometimes combined with other B vitamins. It’s difficult to assess if increasing intake of B6 from dietary sources has the same benefits for certain conditions that supplements may provide.

If you’re interested in taking vitamin B6 supplements to prevent or address a health issue, speak to your healthcare provider about the best option for you. In addition, look for a supplement that has been tested for quality by a third party.

Summary Most
people can get adequate vitamin B6 through their diet. In some cases, taking
higher amounts of vitamin B6 from supplements under the supervision of a doctor
may be beneficial.

Potential Side Effects of Too Much Vitamin B6

Getting too much vitamin B6 from supplements can cause negative side effects.

Vitamin B6 toxicity is not likely to occur from food sources of B6. It would be nearly impossible to consume the amount in supplements from diet alone.

Taking more than 1,000 mg of supplemental B6 a day may cause nerve damage and pain or numbness in the hands or feet. Some of these side effects have even been documented after just 100–300 mg of B6 per day (49).

For these reasons, the tolerable upper limit of vitamin B6 is 100 mg per day for adults (3, 50).

The amount of B6 used to manage certain health conditions rarely exceeds this amount. If you’re interested in taking more than the tolerable upper limit, consult your doctor.

Summary Too
much vitamin B6 from supplements can cause damage to nerves and extremities
over time. If you’re interested in taking a B6 supplement, speak to your
healthcare provider about safety and dosage.

The Bottom Line

Vitamin B6 is a water-soluble vitamin obtained from food or supplements.

It’s needed for many processes in your body, including creating neurotransmitters and regulating homocysteine levels.

High doses of B6 have been used to prevent or treat certain health conditions, including PMS, age-related macular degeneration (AMD) and nausea and vomiting during pregnancy.

Getting enough B6 through your diet or a supplement is crucial for staying healthy and may have other impressive health benefits as well.

what is needed for, what products contain, what is the danger of deficiency

Vitamin B6 was discovered in 1926. Scientists conducted an experiment on rodents. One substance was removed one by one from the food in order to understand which product protects the body from pellagra, a neuropsychiatric disorder. In addition to vitamin B3 (nicotinic acid), scientists have derived pyridoxine, which affects the development of the body. This is how vitamin B6 officially appeared.

What foods contain vitamin B6

You can get vitamin B6 from brewer’s yeast, wheat bran, by-products – kidneys, liver or heart. It is also useful to consume beef, cod, tuna, milk and eggs.

Plant lovers can supplement their daily intake with melon, cauliflower, garlic, broccoli, potatoes, pomegranate, legumes, whole grains, etc. The bioavailability of vitamin B6 in animal products is higher than in vegetable products ¹ .

Why vitamin B6 is needed

Vitamin B6 has three interconvertible forms – pyridoxine (the most common), pyridoxinal and pyridoxamine. Their functions are to maintain protein metabolism and participate in the creation of red blood cells.

Vitamin B6 affects almost all human organs. Contributes to normal protein and fat metabolism. Fights nervous and skin diseases. Relieves the feeling of vomiting and relieves nausea. Synthesizes nucleic acids and protects the skin from premature aging.

Vitamin B6 is involved in many metabolic processes, regulates protein metabolism, participates in the synthesis of hemoglobin, glucose, is responsible for maintaining normal levels of homocysteine.
B6 is one of the main neurotropic vitamins that have an effect on the work of the central and peripheral nervous system.

Strength of mind, endurance and beauty with vitamins of group B

Natural tonic Floradix Vitamin-B-Complex serves as a source of vital vitamins of group B, which are involved in many important metabolic and energy processes, ensure the normal functioning of the nervous, cardio – vascular and immune systems, improve blood formation processes and are responsible for the beauty and youthfulness of the skin. The vitality and emotional state also largely depend on the level of provision with B vitamins. The need for B vitamins increases during periods of significant physical and psychological stress, chronic stress, as well as in old age.

dietary supplement. NOT A DRUG

For the elderly, vitamin B6 is a real protector. Prevents night cramps, muscle spasms, numbness of hands and feet. In diabetics, pyridoxine lowers the amount of sugar in the blood. This substance is used to prevent cardiovascular risks and complications, helps to prevent the development of Alzheimer’s disease.

Doctors prescribe a course of vitamin B6 for anemia, toxicosis during pregnancy, air and sea sickness, as part of the treatment of hepatitis, disorders of the nervous system. And also for various skin diseases – from dermatitis to psoriasis ² .

Daily value of vitamin B6

The dosage of vitamin B6 depends on the person’s age. So infants are recommended to give up to 0.5 mg per day. Children under 10 years old will already need about 1.6 mg per day. Adolescents up to adulthood are sufficient from 1.7 to 2 mg, depending on physical activity.

The daily norm for adult women is 1.8-2.0 mg, for men – 2.0 mg. For pregnant and lactating mothers, the norm increases to 2.3 mg. Seniors over 75 need at least 2.3 mg per day ³ .

Vitamin B6 deficiency

If for no apparent reason a person becomes irritable, drowsy, has no desire to do anything, appetite disappears and nausea appears, then most likely his body needs vitamin B6.

Tonic Floradix Vitamin-B-Complex contains the main vitamins of group B – B1, B2, B3, B6, B7 and B12, which are responsible for the strength of the mind, beauty and endurance, as well as a whole bunch of vegetable juices and extracts, which serve as a valuable source of dietary fiber and bioactive substances, enrich the vitamin and mineral composition of the tonic and enhance its beneficial effect, increase the absorption of vitamins, improve digestion, heal the gastrointestinal tract and give the tonic a wonderful taste and aroma.

The product does not contain preservatives, colors or artificial flavors. Due to the absence of lactose and gluten, it can be consumed by vegetarians and vegans, and the high content of vitamin B12 makes the tonic especially useful for this category of consumers.

dietary supplement. NOT A DRUG

Deficiency of pyridoxine is indicated by dry skin over the eyebrows, around the eyes and on the neck. Painful cracks and sores appear near the mouth, hair begins to thin. Gradually develop conditions such as stomatitis, conjunctivitis, flatulence.

Children have their own set of “first bells”. The lack of vitamin B6 in the body is indicated by the increased excitability of the child, frequent convulsions resembling epileptic seizures, as well as growth retardation or frequent diarrhea. Gradually, anemia or seborrheic dermatitis occurs.

Pyridoxine dietary deficiency is difficult to obtain. This vitamin is partially produced in the intestines, so the problem of deficiency can occur against the background of certain problems: chronic stress, prolonged fever, lack and excess of protein, autoimmune problems, the use of certain drugs ³ .

It is possible to develop a deficiency of vitamin B6 in the body against the background of regular consumption of alcoholic beverages. The intensity of absorption of pyridoxine in the intestine is reduced in smokers.

Vitamin B6 overdose

Vitamin B6, which enters the body with natural food, is practically not accumulated. In cases of overdose, it is excreted naturally – along with urine.

Long-term use of synthetic pyridoxine results in neurological disorders and restless sleep. With uncontrolled use of the substance for 6-12 months, sensory neuropathies may develop, manifested by loss of sensitivity, impaired coordination of movements, skin rashes, and gastrointestinal disorders.

Tonic Floradix Vitamin-B-Complex is recommended for adults and children over 14 years of age to take 20 ml once a day with meals (do not forget to shake before use!).

Duration of admission – 1 month. Taking the tonic at the recommended dose (20 ml per day) provides the daily requirement for thiamine (vitamin B1) by 79% (1.1 mg), riboflavin (vitamin B2) by 88% (1.4 mg), niacin by 89% ( 16mg), Vitamin B6 70% (1.4mg), Vitamin B12 250%* (2.5mcg), Biotin 100%* (50mcg). Strength of the mind, endurance and beauty with B vitamins – now it’s easy!

dietary supplement. NOT A DRUG

Expert comment

– Vitamin B6 is responsible for the nervous system and blood formation. It is often prescribed to the elderly and athletes. Helps to synthesize protein, prevents skin rashes, the same dermatitis and eczema. When deficient, children may have stunted growth, fatigue, drowsiness, inability to concentrate, and irritability. In general, the child’s character instantly deteriorates. The main sources of B6 are beef, offal, chicken, turkey. Pyridoxine is also found in beans, bread, garlic, bread. Overdose with prolonged injections manifests itself in the form of numbness of the arms and legs.

Frequently Asked Questions

How is vitamin B6 absorbed better?

In general, vitamin B6 is well absorbed from food. Absorption is enhanced when the vitamin is taken in combination with magnesium, which improves the ability of B6 to enter cells. Pyridoxine can be combined with vitamin B12 and folic acid.

How do I take vitamin B6?

Vitamin B6 is available in the form of tablets and injections, often included in complete vitamin complexes. The appropriate dosage form is selected by the attending physician. With moderate hypovitaminosis, tablets are more often recommended, and with severe hypovitaminosis, injections are prescribed. To determine the level of vitamin B6 in the blood and the subsequent selection of an effective method for its correction, the patient should undergo a laboratory test (donate blood).

Can vitamin B6 be taken with other vitamins or medicines?

Vitamin B6 actively interacts with other vitamins and minerals. When used together with calcium, pyridoxine has a positive effect on the work of the heart. In combination with vitamin B9, B12, the substance restores the functioning of the central nervous system, treats some types of anemia.

COCs (contraceptives), asthma medications, barbiturates, anti-epileptics and anti-tuberculosis drugs can weaken the effect of vitamin B6.

Pyridoxine reduces the effect of drugs used to treat Parkinson’s disease. Enhances the action of diuretics.

When using vitamin B6 in the form of a solution for injection, it should not be mixed with B1 and B12 alone. With this combination, vitamins lose their properties.

Sources:

1. Breshchenko E.E., Melkonyan K.I. Biologically active substances. Vitamins, enzymes, hormones. Krasnodar, 2019
2. Rakhimova DF Bioactivity of vitamin B 6 and its derivatives (brief review of foreign publications) // Bulletin of the Kazan Technological University. 2012. No. 16. https://cyberleninka.ru/article/n/bioaktivnost-vitamina-v-6-i-ego-proizvodnyh-kratkiy-obzor-zarubezhnyh-publikatsiy
3. https://ods.od.nih.gov/factsheets/VitaminB6-HealthProfessional/

How to use vitamin B6 for hair growth and hair loss?

Vitamin B6 is present in the body in three forms: pyridoxine, pyridoxal, pyridoxamine. All of them have the same biological activity. The daily human need for this element is 2–3 mg.

The main functions of Vitamin B6

Vitamin B6:

1. Plays a key role in the metabolism of amino acids: serine, threonine, tryptophan, cysteine, methionine.
2. Participates in the synthesis of the hema-protein part of hemoglobin.
3. Necessary for the formation of neurotransmitters that regulate the functioning of the brain and peripheral nervous system: GABA (gamma-aminobutyric acid), serotonin, dopamine, glutamic acid, norepinephrine.
4. For antibody synthesis.
5. Affects the process of cell division.
6. Required for the synthesis of hydrochloric acid in the stomach.
7. Supports healthy skin and hair. With a lack of vitamin B6, dermatitis develops, hair becomes lifeless, and their growth stops.

Direct effect on hair health

Vitamin B6 is primarily involved in the process of moisturizing the hair. With its lack, excessive dryness occurs, the hair looks lifeless, there is no healthy shine. Also, pyridoxine soothes the scalp, allows you to get rid of itching, redness and peeling, which is often accompanied by the appearance of dandruff.

Vitamin B6 in sufficient quantity normalizes the functioning of the sebaceous glands and stabilizes the oiliness of the scalp. This allows you to wash your hair less often, as the hair stays clean longer.

A person can receive vitamin B6 to normalize the condition of the hair and improve their condition in 2 ways:

• take orally;
• should be used externally – directly on the hair.

Pyridoxine by mouth

The vitamin can be obtained from food – naturally – or in the form of drugs that can be purchased at a pharmacy.

Food

Vitamin B6 is found in a large number of foods.

Grain sprouts, walnuts and hazelnuts, spinach, potatoes and sweet potatoes, carrots, cauliflower and white cabbage, tomatoes, strawberries, cherries, oranges and lemons, avocados are especially rich in them.

Slightly less in meat and dairy products, fish, eggs, cereals and legumes.

Important! Vitamin B6 is partially synthesized in the body by intestinal microflora. Therefore, with a varied diet and a healthy intestine, deficiency develops extremely rarely.

Preparations

Vitamin B6 and other vitamins of this group can be used as part of various vitamin complexes or as a food supplement. The method of use is indicated in the instructions for the drug, but they are usually taken daily, 1 or several times a day.

Brewer’s yeast is produced in the form of capsules, which, in addition to pyridoxine itself, also contain folic acid, E vitamins, as well as a whole complex of micro and macro elements (zinc, potassium, iron). The drug is quickly and easily absorbed, and also produces a visible effect after a short period of time. Mainly brewer’s yeast can significantly reduce the activity of the sebaceous glands, as well as strengthen the structure of the hair, making it less brittle, resistant to external influences.

Aleran’s vitamin complex primarily affects the appearance of the hair and the health of the scalp. Natural shine appears, hair becomes smoother due to the restoration of their structure. It is taken 2 times a day, and there are special capsules for taking in the morning and in the evening – the rhythm of hair growth was taken into account during development.

Important! Never take vitamin B6 without monitoring its level. Vitamin B6 in excess in the body has a toxic effect and causes disorders of the nervous system.

External use

Local use of vitamin B6 is possible both with the use of pharmaceutical preparations and as part of homemade masks.

Preparations

Vitamin B6 in ampoules can be simply rubbed into the scalp. The indication for use is usually considered to be profuse hair loss. However, the drug can also be used to prevent seasonal hair loss or as part of courses to maintain the desired volume of hair.

Usage algorithm:

1. You can only get a result if you complete the full course of treatment. Irregular use of the product will not give any visible effect.
2. Rub the contents of the ampoule into the scalp, but attention should also be paid to the ends of the hair, as they usually look more lifeless in the total mass.
3. It is not recommended to store an open ampoule, as the shelf life of a vitamin in an open container is very short.
4. For convenience, you can mix the vitamin with shampoo, balm or ready-made cosmetic masks.
5. The procedure is best done in the evening so that the effect of the vitamin lasts all night.

Home masks

Among the most popular common recipes:

1. Mask based on burdock oil. 50 ml of oil and 2 ampoules of pyridoxine must be mixed – this amount is designed for 1 application. You can use this mask every 2 weeks. The composition is applied to the hair, which should then be wrapped with a film for 2 hours. Then it is washed off with shampoo.
2. Mask based on almond oil. You need to mix 20 ml of heated oil, 1 beaten egg and 2 ampoules of vitamin. The product is applied to the hair, which should then be wrapped with a film for 1 hour, and then washed off with shampoo.
3. Yeast mask. Pour 1 tablespoon of yeast into warm water and leave for 30 minutes to revive. Then add the same amount of honey, leave for another 20-30 minutes, apply the product on your hair, wrap your hair in a warm towel and leave the mask on all night.