Vasopressin tablets: Vasopressin Uses, Side Effects & Warnings

07.04.202316.07.2023 by alexxlab

DDAVP Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Warnings:

Desmopressin can rarely cause a low level of sodium in the blood (hyponatremia), which can be serious or even fatal. Drinking too much liquid, using certain medications (such as “water pills”/diuretics including furosemide, glucocorticoids such as prednisone), being 65 years or older, or having certain medical conditions may increase the risk of low sodium in the blood. Lab tests (such as urine tests, sodium blood levels) must be done before you start using this medication and while you are using it. Keep all medical and lab appointments.

Tell your doctor right away if you develop symptoms of low sodium in the blood, such as nausea, vomiting, headache, muscle weakness/cramps, unusual tiredness, unusual drowsiness, dizziness, restlessness, mental/mood changes including confusion/irritability.

Get medical help right away if you have any very serious side effects, including seizure or trouble breathing.

Warnings:

Get medical help right away if you have any very serious side effects, including seizure or trouble breathing.

Uses

Desmopressin is used to control the amount of urine your kidneys make. Normally, the amount of urine you make is controlled by a certain substance in the body called vasopressin. In people who have “water diabetes” (diabetes insipidus) or certain kinds of head injury or brain surgery, the body does not make enough vasopressin. Desmopressin is a man-made form of vasopressin and is used to replace a low level of vasopressin. This medication helps to control increased thirst and too much urination due to these conditions, and helps prevent dehydration.Desmopressin is also used to control nighttime bedwetting in children. It reduces how often your child urinates and decreases the number of bedwetting episodes.

How to use DDAVP

For the treatment of diabetes insipidus, take this medication by mouth, usually 2 to 3 times a day or as directed by your doctor.

For the treatment of bedwetting, take this medication by mouth, usually once a day at bedtime. Children should limit the fluids they drink after dinner, especially 1 hour before the desmopressin dose until the next morning, or at least 8 hours after the dose. If your child wakes up during the night, limit the amount that your child drinks.

All patients taking desmopressin, especially children and older adults, must limit drinking of water and other fluids. Consult your doctor for details. If you find that you are drinking more fluids than directed, tell your doctor right away. Your treatment will need to be adjusted.

Dosage is based on your medical condition and response to treatment. Do not take more desmopressin or take it more often than prescribed.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

Tell your doctor if your condition does not improve or if this medication stops working well.

Side Effects

Precautions

Before taking desmopressin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, high blood pressure, heart problems (such as blocked blood vessels, heart failure), conditions that may increase your risk of fluid/mineral imbalance (such as cystic fibrosis), the urge to drink too much water without being thirsty, a low level of sodium in the blood (hyponatremia), bleeding/clotting problems.

If you become dehydrated, your doctor will correct that condition first before starting treatment with desmopressin.

Limit alcohol because it can interfere with how well desmopressin works.

Tell the doctor right away if you develop any illness that can cause water/mineral imbalance (including fever, diarrhea, vomiting, infections such as the flu) or if you experience conditions that require drinking more fluids (for example, exposure to very hot weather, strenuous exercise, heavy sweating). The doctor may need to stop or adjust desmopressin treatment, especially in children and older adults.

Children may be more sensitive to the side effects of this drug, especially water/mineral imbalance and a low level of sodium in the blood.

Older adults may be at greater risk for water/mineral imbalance and a low level of sodium in the blood while using this drug.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

This medication passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Some products that may interact with this drug are: tolvaptan, “water pills”/diuretics (such as furosemide).

Does DDAVP interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: headache that is severe or doesn’t go away, confusion, drowsiness, sudden weight gain.

Do not share this medication with others.

Lab and/or medical tests (such as urine tests, sodium blood level) may be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

If you take 1 dose daily and miss a dose, take it as soon as you remember. If you do not remember until the next day, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

If you take more than 1 dose daily and miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

DDAVP 0.2 mg tablet

Color: whiteShape: roundImprint: 0.2

This medicine is a white, round, scored, tablet imprinted with “0.2”.

DDAVP 0.1 mg tablet

Color: whiteShape: ovalImprint: 0.1

This medicine is a white, round, scored, tablet imprinted with “0.2”.

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Drug Survey

Are you currently using DDAVP?

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Diabetes insipidus – Treatment – NHS

Treatments for diabetes insipidus aim to reduce the amount of urine your body produces.

Depending on the type of diabetes insipidus you have, there are several ways of treating your condition and controlling your symptoms.

Cranial diabetes insipidus

Mild cranial diabetes insipidus may not require any medical treatment.

Cranial diabetes insipidus is considered mild if you produce approximately 3 to 4 litres of urine over 24 hours.

If this is the case, you may be able to ease your symptoms by increasing the amount of water you drink to avoid dehydration.

Your GP or endocrinologist (a specialist in hormone conditions) may advise you to drink a certain amount of water every day, usually at least 2.5 litres.

But if you have more severe cranial diabetes insipidus, drinking water may not be enough to control your symptoms.

As your condition is caused by a shortage of vasopressin (AVP), your GP or endocrinologist may prescribe a treatment that takes the place of AVP, known as desmopressin.

Desmopressin

Desmopressin is a manufactured version of AVP that’s more powerful and more resistant to being broken down than the AVP naturally produced by your body.

It works just like natural AVP, stopping your kidneys producing urine when the level of water in your body is low.

Desmopressin can be taken as a nasal spray, in tablet form or as a form that melts in your mouth, between your gum and your lip.

If you’re prescribed desmopressin as a nasal spray, you’ll need to spray it inside your nose once or twice a day, where it’s quickly absorbed into your bloodstream.

If you’re prescribed desmopressin tablets, you may need to take them more than twice a day.

This is because desmopressin is absorbed into your blood less effectively through your stomach than through your nasal passages, so you need to take more to have the same effect.

Your GP or endocrinologist may suggest switching your treatment to tablets if you develop a cold that prevents you using the nasal spray.

Desmopressin is very safe to use and has few side effects.

But possible side effects can include:

headache
stomach pain
feeling sick
a blocked or runny nose
nosebleeds

If you take too much desmopressin or drink too much fluid while taking it, it can cause your body to retain too much water.

This can result in:

headaches
dizziness
feeling bloated
hyponatraemia – a low level of sodium (salt) in your blood

Symptoms of hyponatraemia include:

a severe or prolonged headache
confusion
feeling sick (nausea) and vomiting

If you think you may have hyponatraemia, stop taking desmopressin immediately and call your GP for advice.

If this is not possible, go to your local A&E department.

Nephrogenic diabetes insipidus

If you have nephrogenic diabetes insipidus that’s caused by taking a particular medication, such as lithium or tetracycline, your GP or endocrinologist may stop your treatment and suggest an alternative medication.

But do not stop taking it unless you have been advised to by a healthcare professional.

As nephrogenic diabetes insipidus is caused by your kidneys not responding to AVP, rather than a shortage of AVP, it usually cannot be treated with desmopressin.

But it’s still important to drink plenty of water to avoid dehydration.

If your condition is mild, your GP or endocrinologist may suggest reducing the amount of salt and protein in your diet, which will help your kidneys produce less urine.

This may mean eating less salt and protein-rich food, such as processed foods, meat, eggs and nuts.

Do not alter your diet without first seeking medical advice.

Your GP or endocrinologist will be able to advise you about which foods to cut down on.

Find out more about eating a healthy, balanced diet.

If you have more severe nephrogenic diabetes insipidus, you may be prescribed a combination of thiazide diuretics and a non-steroidal anti-inflammatory drug (NSAID) to help reduce the amount of urine your kidneys produce.

Thiazide diuretics

Thiazide diuretics can reduce the rate the kidneys filter blood, which reduces the amount of urine passed from the body over time.

Side effects are uncommon, but include:

dizziness when standing
indigestion
very sensitive skin
erectile dysfunction (impotence) in men

This last side effect is usually temporary and should resolve itself if you stop taking the medication.

Non-steroidal anti-inflammatory drugs (NSAIDs)

Non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, help reduce urine volume further when they’re used in combination with thiazide diuretics.

But long-term use of NSAIDs increases your risk of developing a stomach ulcer.

To counter this increased risk, an additional medication called a proton pump inhibitor (PPI) may be prescribed.

PPIs help protect your stomach lining against the harmful effects of NSAIDs, reducing the risk of ulcers forming.

Find out more about treating stomach ulcers

Help with health costs

If you have diabetes insipidus, you do not have to pay prescription charges for desmopressin.

You’ll need to fill in a medical exemption (MedEx) certificate to qualify.

See who can get free prescriptions for more information about how to apply for a MedEx certificate.

You may have to pay for other medicines that may be required on a short-term basis, such as thiazide diuretics.

Support

Read more about diabetes insipidus and how to get support from the Pituitary Foundation

Page last reviewed: 13 October 2022
Next review due: 13 October 2025

Fidelity Pills – KP.RU

Komsomolskaya Pravda

Search results 004 Scientists are encouraging: a substance has been found on the basis of which it is possible to create a drug against adultery

As it turned out, as many as two issues of the “Man and Woman” column, which were devoted to the scientific search for the reasons for going to the left and ways to stop them, did not cover the whole variety of topics (“Is there a cure for adultery?”, “Coercion to fidelity”, see . “KP” dated September 6 and 13, 2008). Recently, new discoveries have arrived. And they testify: not only instincts and psychology are involved in adultery. But also chemistry. A substance has been discovered that averts fornication and generates a sense of fidelity to a single partner. Thanks to him, according to scientists, next to us there are people who can not change.

Cheating genes

The search for the chemical causes of infidelity began about seven years ago. And, as usual, from experiments on mice. Fortunately, among these animals there are two amazing populations – meadow voles and steppe voles. The males of the first are extremely lascivious, mating right and left. And those from the second, all their mouse life remain faithful to one female. Scientists decided to figure out why such a miracle happens. And they seem to have figured it out.

“Our study, in a relatively simple biological model, provides evidence that boosting the activity of just one gene profoundly changes the foundations of social behavior,” said Larry Young, a professor at Emory University in Georgia.

It turned out that the heads of faithful and unfaithful mice contain a different number of receptors that perceive the hormone vasopressin. It is produced by the brain in one area, and absorbed in another. This hormone, scientists have suggested, and generates a sense of attachment. Moreover, it creates a very pleasant feeling that one female is enough to satisfy sexual needs. The bold hypothesis was also reinforced by the fact that the faithful mice showed an excess of both the hormone itself and the receptors that perceive it.

To test, American neuroscientists transferred the gene responsible for vasopressin receptors from monogamous steppe voles to meadow lovers to go left. And a fantastic transformation happened: the Casanova mice became faithful “husbands” without exception. This is the magical power of chemistry.

People are like mice

Impressive results were obtained back in 2004. But since they belonged to “simple biological models”, they did not create confidence that they could be transferred to more complex ones – to people. Doubts were dispelled by recent research conducted at the Swedish Karolinska Institute under the direction of Professor Hass Walum. Scientists have discovered a striking similarity between people and their smaller brothers in terms of the chemical nature of adultery. It turned out that the human brain interacts with vasopressin in exactly the same way as the mouse. Faithful men found more of the hormone, and it was absorbed better. For cheaters, the opposite is true. And the reason is the same – the genetic difference of one from the other.

Conclusions: vasopressin has a serious claim to be the human hormone of fidelity. This is first. Secondly, not all men are cheaters. There is a breed of people in whom nature has beaten off the inclination to fornication, while retaining both the libido and the ability to receive sincere satisfaction from sexual intercourse with a single partner. Such, according to opinion polls, from a quarter to a third of the stronger sex.

Alas, it is still a mystery whether there is a genetic difference between women of easy sexual behavior and those who profess marital fidelity.

Prescribe me, doctor…

Vasopressin is a known hormone. News – its role in human relationships and in influencing social behavior. Naturally, the question arises: is it possible, on the basis of this hormone, to create a drug for the “treatment” of infidelity? Theoretically – yes, scientists answer. But more research is needed. After all, it is stupid to drink vasopressin or inject it dangerously. Like any hormone. Yes, and there are side effects – the most famous, for example, difficult urination (analogs of vasopressin are prescribed for patients with enuresis). Would a healthy husband in this sense want to make such a sacrifice? However, medical science does not stand still. Scientists will come up with something – synthetically harmless. And make humanity happy with fidelity pills.

Vladimir LAGOVSKY

SPECIALIST’S OPINION

Dilute with tenderness!

Natalia GRIDASOVA, psychoendocrinologist, doctor of the highest category:

– Vasopressin belongs to a group of hormones that are produced by a very important part of the brain – the pituitary gland, and is responsible for regulating the amount of fluids in the body. And disinhibited sexual behavior (simply – pathological infidelity) is often distinguished by people who have just the same function of the pituitary gland.

Of course, it is impossible to say directly, they say, inject your “walker” with vasopressin, and he will sit beside you like silk. But perhaps there is a rational grain in these studies. And the medicine “for infidelity” will act just on those men who run to the left not because of natural depravity or because the partner does not suit, but “due to illness.”

Vasopressin also affects the secretion of oxytocin, the hormone of tenderness, which is responsible for the emotional component of sexual relations and enhances attachment to a partner.

In large doses, vasopressin greatly increases pressure in tissues, including the brain, and this can be very dangerous for health.

Elena IONOVA.

BTW

Sleep well

Endocrinologists at the Faculty of Medicine of the University of Lübeck, led by Jan Born, discovered that inhaling an aerosol preparation containing vasopressin in the morning and evening has a hypnotic effect. But it also weakens memory.

In principle, an attractive combination of side effects: a faithful husband sleeps well, pees little and does not remember insults.

Maybe scientists are trying in vain? There is little demand for chastity pills. Slightly higher than on a baldness balm. It is strange, however… Although there are suspicions that in our sociological survey mainly traitors participated, for whom some kind of “non-leftist” is a threat to a lustful lifestyle. Like bromine for Casanova. Or do people really cope with adultery non-drug? Through love and willpower? And rely on natural feelings? Showing no interest even in a love potion?

Another interpretation is not ruled out. Logically sound. After all, if you restore a peppy and fresh look, become smart and slender teetotalers, then other problems – partner’s infidelity, baldness and insufficient attention of the opposite sex – will seem secondary and easily solved. This is what Faust thought when he sold his soul. Looks like we haven’t changed much since then?

Vladimir Lagovsky is waiting for your feedback on our website.

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