Vitamins for grey hair reversal. Vitamins for Gray Hair Reversal: Top Nutrients to Prevent Premature Graying

20.06.197105.08.2021 by alexxlab

What causes premature gray hair. How can vitamins help prevent early graying. Which nutrients are essential for maintaining hair pigmentation. Can gray hair be reversed with supplements. What lifestyle changes can slow down hair graying.

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The Science Behind Gray Hair: Understanding the Causes

Gray hair is a natural part of the aging process, but premature graying can be concerning for many individuals. To understand how to potentially prevent or slow down this process, it’s crucial to first examine the underlying causes of gray hair.

What Causes Hair to Turn Gray?

Hair color is determined by melanin, a pigment produced in the hair follicles. As we age, melanin production decreases, resulting in gray or white hair. However, several factors can accelerate this process:

Vitamin deficiencies
Genetics
Medical conditions
Stress
Smoking
Chemical hair products
Environmental factors

While genetics play a significant role in determining when you’ll start to gray, other factors can be controlled to some extent. Let’s delve deeper into each of these causes.

The Role of Vitamin Deficiencies in Premature Graying

Proper nutrition is essential for maintaining healthy hair pigmentation. Certain vitamin deficiencies have been linked to premature graying.

Which Vitamins Are Crucial for Hair Pigmentation?

Research has identified several key nutrients that may help prevent premature graying:

Vitamin B12
Vitamin D3
Vitamin E
Copper
Iron
Zinc
Biotin

A study found that individuals under 25 with premature graying often had low levels of serum ferritin, vitamin B12, and HDL-C (good cholesterol). This suggests that addressing these deficiencies may help slow down the graying process.

Genetic Factors in Hair Graying: Is It Inevitable?

While we can’t change our genetic makeup, understanding the role of genetics in hair graying can help us better manage our expectations and take proactive steps to maintain hair health.

How Do Genetics Influence Gray Hair?

The gene IRF4 (interferon regulatory factor 4) plays a crucial role in hair color. It regulates melanin production and is associated with the graying process. If your parents or grandparents experienced premature graying, you may be more likely to develop gray hair at an early age.

However, it’s important to note that having a genetic predisposition to gray hair doesn’t mean it’s inevitable. Environmental factors and lifestyle choices can still influence the timing and extent of graying.

Medical Conditions and Gray Hair: Unexpected Connections

Certain medical conditions can directly affect hair pigmentation and contribute to premature graying.

Which Medical Conditions Can Cause Gray Hair?

Vitiligo: This condition affects melanin production in the skin and can also impact hair follicles.
Thyroid dysfunction: Thyroid issues can disrupt the hair follicle cycle and pigmentation.
Alopecia areata: This autoimmune disease can cause hair loss and depigmentation (poliosis).

If you’re experiencing premature graying along with other unexplained symptoms, it’s important to consult with a healthcare professional to rule out underlying medical conditions.

The Stress Factor: How Stress Affects Hair Color

We’ve all heard the phrase “stress is turning my hair gray,” but is there any truth to this claim?

Can Stress Really Cause Gray Hair?

Recent research suggests that stress can indeed contribute to graying hair. A study on mice revealed that both physiological and psychological stress could lead to melanocyte loss in stem cells, resulting in gray hair.

The mechanism behind this involves the sympathetic nervous system releasing noradrenaline under stress. This activates stem cells that change into melanocytes, which then migrate away from the hair follicles, leading to gray or white hair.

Lifestyle Factors: Smoking, Chemical Products, and Environmental Impact

Our daily habits and environment can significantly impact hair health and pigmentation.

How Does Smoking Affect Hair Color?

Smoking not only harms overall health but also accelerates hair graying. It reduces blood flow to hair follicles and exposes them to harmful toxins. Studies have shown that smokers are twice as likely to experience premature graying before age 30 compared to non-smokers.

Are Chemical Hair Products Contributing to Gray Hair?

While chemical hair dyes are often used to cover gray hair, excessive use of these products may ironically contribute to premature graying. Harsh chemicals in dyes and some hair care products can affect melanin levels in the hair strands. Prolonged exposure to substances like hydrogen peroxide may fade hair color and accelerate graying.

How Do Environmental Factors Influence Graying?

Environmental pollutants and UV radiation can generate free radicals that damage melanin in hair strands, speeding up the graying process. Protecting your hair from excessive sun exposure and pollution can help maintain its natural color for longer.

Vitamins and Nutrients for Gray Hair Prevention

While it’s not possible to reverse graying in hair strands that have already lost their pigment, certain vitamins and nutrients may help prevent premature graying and preserve existing color.

Which Vitamins Are Most Effective for Preventing Gray Hair?

Vitamin D: Essential for both bone and hair health, vitamin D deficiency has been linked to premature graying. Incorporate foods like eggs, mushrooms, fatty fish, meat, and dairy products into your diet. Vitamin D supplements may also be beneficial.
Vitamin B12: One of the most common deficiencies associated with premature graying. Vitamin B12 helps reduce homocysteine levels, which can contribute to hair bleaching. Foods rich in B12 include meat, eggs, milk, and fish. The recommended daily intake for most adults is 2.4 mcg.
Vitamin B9 (Folate): Often used in conjunction with B12 to combat premature graying. Good sources include leafy greens, legumes, and fortified grains.
Biotin: While more research is needed, some studies suggest biotin may help maintain hair pigmentation. It’s found in foods like eggs, nuts, and whole grains.
Vitamin E: An antioxidant that may help protect hair follicles from oxidative stress. Found in nuts, seeds, and vegetable oils.
Iron: Iron deficiency anemia has been associated with premature graying. Include iron-rich foods like red meat, spinach, and lentils in your diet.
Copper: Plays a role in melanin production. Good sources include shellfish, nuts, and seeds.

While these nutrients are important for overall hair health, it’s crucial to maintain a balanced diet rather than relying solely on supplements. Always consult with a healthcare professional before starting any new supplement regimen.

Lifestyle Changes to Support Healthy Hair Pigmentation

In addition to proper nutrition, certain lifestyle changes can help maintain natural hair color for longer.

What Lifestyle Changes Can Help Prevent Premature Graying?

Quit smoking: Eliminating this habit can improve overall health and potentially slow down the graying process.
Manage stress: Incorporate stress-reduction techniques like meditation, yoga, or regular exercise into your routine.
Protect your hair: Use hats or hair products with UV protection when exposed to sunlight for extended periods.
Choose gentle hair care products: Opt for natural, chemical-free hair care products to minimize damage to hair follicles.
Stay hydrated: Proper hydration supports overall hair health and may help maintain pigmentation.
Get regular check-ups: Annual health screenings can help detect and address any nutrient deficiencies or underlying health conditions that may contribute to premature graying.

While these changes won’t reverse existing gray hair, they can help maintain the health and color of your remaining pigmented strands.

The Future of Gray Hair Research: Potential Breakthroughs

As our understanding of hair biology continues to evolve, researchers are exploring new avenues for preventing or reversing gray hair.

What New Treatments for Gray Hair Are on the Horizon?

Several promising areas of research are currently being explored:

Stem cell therapy: Scientists are investigating ways to stimulate melanocyte stem cells to produce pigment in gray hair follicles.
Gene therapy: Targeting specific genes involved in hair pigmentation may offer future solutions for premature graying.
Topical treatments: Researchers are developing new formulations that may help restore melanin production in the hair follicle.
Nutraceuticals: Advanced supplements combining multiple nutrients and antioxidants are being studied for their potential to prevent or slow down graying.

While these potential treatments are still in the early stages of research, they offer hope for more effective solutions to gray hair in the future.

In conclusion, while completely reversing gray hair remains challenging, understanding the causes of premature graying and taking proactive steps can help maintain natural hair color for longer. By focusing on proper nutrition, adopting a healthy lifestyle, and staying informed about the latest research, individuals can take control of their hair health and potentially slow down the graying process. Remember, gray hair is a natural part of aging and can be embraced as a sign of wisdom and experience. Whether you choose to cover your grays or let them shine, the most important factor is maintaining the overall health of your hair and body.

Gray Hair Reversal: Vitamins And Supplements

No. Vitamin supplements cannot reverse gray hair. However, they can prevent premature graying. While graying is a part of the aging process and inevitable, premature graying is an issue.

You cannot restore the original color of the gray strands, but you can prevent premature graying with the right vitamin supplements and a few lifestyle changes. In this article, we have shared a list of the top vitamins and supplements to prevent premature graying. Scroll down to know more!

What Causes The Hair To Turn Gray?

The hair follicles contain melanin that gives the hair its color. With age, the hair can lose melanin, turning the strands silver or white. While this is common during old age, if you notice gray hair in your early 20s and 30s, here are the common causes:

1. Vitamin Deficiencies

Vitamin deficiencies can affect hair pigmentation and cause premature graying. The lack of trace elements like vitamins B12, D3, E, copper, iron, zinc, and biotin can contribute to premature graying (1), (2). A study found low serum ferritin, vitamin B12, and HDL-C (good cholesterol) levels to cause premature graying in individuals under 25 years of age (3).

2. Genetics

You might blame your unruly teens or stressful job for your gray hair. But gray hair can be an inherited trait. Genetics can influence the hair follicle stem cells and melanocytes and cause premature graying (2).

You are likely to have gray hair at an early age if your parents or grandparents had premature graying. The gene IRF4 (interferon regulatory factor 4) plays a key role in hair color. It helps regulate melanin production and is also responsible for gray hair (4).

3. Medical Conditions

Certain medical conditions like vitiligo directly alter human hair follicle functions and cause graying. Thyroid dysfunction is linked with hair abnormalities. It affects the hair follicle cycle and pigmentation (5).

Alopecia areata, an autoimmune disease, causes hair loss and poliosis (depigmentation of hair). A case study found that poliosis could be caused by autoimmune conditions, infections, genetic syndromes, cutaneous lesions, trauma, and medication usage (6).

4. Stress

Acute stress can turn the hair gray. A mice study revealed that pain (physiological stress) and psychological stress could cause melanocyte loss in the stem cells and cause graying.

The researchers also found that under stress, the sympathetic nervous system releases noradrenaline and activates the stem cells that change to melanocytes. These melanocytes migrate away from the hair follicles, turning the hair gray and white (7).

5. Smoking

Smoking is injurious not only to your physical health but also to your hair health. Smoking reduces the blood flow to hair follicles, and the toxins in cigarettes can affect them, causing early graying. Compared to non-smokers, smokers have double the chances of premature graying before hitting their 30s (8), (9).

6. Chemical Hair Dyes And Products

Do chemical hair dyes only hide your grays? Not really! Excessive use of chemical hair dyes can cause premature graying. The chemical hair dyes and harsh hair care products like shampoos contain chemicals that may affect the melanin levels in the strands. Prolonged exposure to chemicals like hydrogen peroxide may fade the hair color and cause graying.

7. Pollution And UV Exposure

Excessive UV ray exposure and environmental factors like pollution may cause graying. Pollutants in the air generate free radicals that damage melanin in the hair strands, speeding up hair graying (10).

You cannot control hair graying if it is in your genes. However, you can control the other extrinsic factors to minimize graying. It is impossible to reverse graying in strands that have already turned gray. But adding the right nutrients to your diet may preserve the existing color pigments and slow down the graying process.

Vitamins For Gray Hair Reversal

Enrich your diet with the following vitamins and nutrients to prevent premature graying:

Vitamin D is essential not only for bone health but also for hair health. Studies found vitamin D deficiency as one of the reasons for premature graying (11). Vitamin D affects melanin production in the hair follicles. Hence, consume food items like eggs, mushrooms, fatty fish, meat, and dairy products to combat vitamin D deficiency. You may also take vitamin D supplements.

Vitamin B12 deficiency is the most common cause of premature graying (12). Elevated homocysteine levels in the body generate hydrogen peroxide that bleaches the hair, turning it gray. Taking vitamin B12 supplements reduces homocysteine levels and prevents premature hair graying. Intake of foods rich in vitamin B12 like meat, eggs, milk, and fish can help in gray hair reversal. A daily dosage of 2.4 mcg is recommended for most adults (13).

Vitamin B9 or folate is often used to increase hair growth and plays a significant role in maintaining hair pigmentation. Lack of folic acid in your diet causes gray hair and pigmentation changes in the nails and skin. Consume folic acid-rich foods like kale, beans, green peas, leafy greens, citrus fruits, eggs, and poultry. The daily recommended dietary intake of folic acid for adults is 400 mcg (14).

Anecdotal evidence suggests that vitamin B5 or pantothenic acid can prevent premature hair graying. It is said to play a key role in melanin production and can restore your natural hair color. You can get vitamin B5 from food sources, such as leafy greens, mushrooms, yogurt, whole grains, eggs, beans, fish, liver, and beef.

Low iron levels in the body can lead to hair thinning and premature graying (15). To minimize the deficiency, consume foods like kale, eggs, spinach, red peppers, and peach. Also, foods that are rich in vitamin C help absorb more iron.

Calcium is a key mineral for maintaining your bone strength and hair color. Intake of foods rich in calcium, such as leafy greens, kale, milk, fish, walnuts, cabbage, and fortified cereals, may prevent premature graying (16).

Zinc may influence melanin production and cause premature graying (2). Consuming meat, beans, whole grains, pumpkin seeds, red meat, and fish may help deal with zinc deficiency and prevent gray hair.

If you are not getting enough vitamins through your diet, consult a doctor and consider taking supplements to prevent graying. You may take supplements for the vitamins mentioned above or opt for the following.

Supplements For Gray Hair Reversal

Vitamin B6: The deficiency of vitamin B6 is more prominent among people who do not eat meat. Oral vitamin B6 supplements may promote melanin development in the hair (17). A daily dietary intake of 1.3 mg vitamin B6 is recommended for adults (18).
Biotin: You may take biotin supplements to prevent premature graying (2). The recommended daily intake of biotin is 30 mcg for adults (19)
Copper: This antioxidant is a key component of melanin, and copper deficiency causes premature graying (2).

The Takeaway

You cannot reverse graying. However, you can prevent the natural loss of melanin from the hair strands and slow down the graying process by taking the right vitamins and supplements. If your hair is turning gray, consult a doctor to check for nutritional deficiencies or underlying health conditions. Follow the prescribed treatment and dietary recommendations to maintain hair health and prevent premature graying.

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Sindhu Koganti is a Biotechnology graduate and has been in the writing field for over 4 years now. She specializes in writing on Health and Wellness. She has hands-on experience in writing articles and press releases on Life Sciences and Healthcare, Food and Beverages, and Chemicals and Materials. When she’s not writing, she loves watching movies and listening to music. She also enjoys traveling.

There might be lot of causes due to which your hair turns grey in your teenage. Premature hair graying is the most commonly faced problems by most of the people in their 20s. I strongly believe that, food has and will always play a major role on not just how your skin and hair feels but your entire body too. Even though there are so many ways from which you can benefit to cover your grays naturally, this post is something different.

Vitamin B-12 is an essential vitamin, and while gray hair is not one of the primary symptoms of low vitamin B-12 in your system, it can cause graying hair. A recent case study of reversible generalized hyperpigmentation of the skin and nails with reversible premature gray hair due to vitamin B12 deficiency is reported. The pigmentation of the skin and hair returned to normal after treatment with intramuscular cyanocobalamin (injection is used to treat or prevent vitamin B12 deficiency).

Vitamin B7(Biotin) has many benefits. It produces keratin which is a major component of hair and nails. It triggers hair growth, it treats hair loss related disorders, and it thickens and strengthens the hair. One of our favorite beneficial effects of Biotin is that is can reverse premature greying of hair. Research has indicated the role of diet in staving off or reversing hair discoloration.

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Hair graying is a common sign of aging resulting from complex regulation of melanogenesis. Currently, there is no medical treatment available for hair repigmentation. In this article we review the literature on medication-induced hair repigmentation, discuss the potential mechanisms of action, and review the quality of the literary data. To date, there have been 27 studies discussing medication-induced gray hair repigmentation, including 6 articles on gray hair repigmentation as a primary objective, notably with psoralen treatment or vitamin supplementation, and 21 reports on medication-induced gray hair repigmentation as an incidental finding. Medications noted in the literature include anti-inflammatory medications (thalidomide, lenalidomide, adalimumab, acitretin, etretinate, prednisone, cyclosporin, cisplatinum, interferon-α, and psoralen), stimulators of melanogenesis (latanoprost, erlotinib, imatinib, tamoxifen, and levodopa), vitamins (calcium pantothenate and para-amino benzoic acid), a medication that accumulates in tissues (clofazimine), and a medication with an undetermined mechanism (captopril). Diffuse repigmentation of gray hair can be induced by certain medications that inhibit inflammation or stimulate melanogenesis. There is also low-quality evidence that some vitamin B complex supplementation can promote gray hair darkening. While these compounds are not currently indicated for the treatment of gray hair, their mechanisms shed light on targets for future medications for hair repigmentation.

Hair color has long been a symbol of youth and health, with graying signifying advanced age. Topical means of hair coloring such as permanent hair dyes are affordable and easy to use; however, they can cause irritation of the scalp, allergic reactions, and damage to the hair shaft [1]. Semipermanent and temporary hair dyes are gentler, but since they do not penetrate the hair cortex, they do not camouflage gray hair as well [1].

An optimal therapy would permanently reverse the gray back to its original hair color, without causing damage to the hair shaft or scalp irritation. In a quest for development of this type of therapy, anecdotal reports of medications associated with hair repigmentation have been described. Unfortunately, many cases are not definitively reproducible, and little is understood about the pathophysiology behind hair repigmentation.

Graying of hair, also called canities or achromotrichia, is part of the natural aging process. It has been reported that worldwide 6–23% of people have 50% gray hair by 50 years of age [2]. Graying typically begins in the mid-30s for Caucasians, the late-30s for Asians, and the mid-40s for Africans [3-5]. Premature hair graying is considered when the onset of gray hair begins before the age of 20 years in Caucasians, before the age of 25 years in Asians, and before the age of 30 years in Africans [5, 6].

The human hair shaft is composed of two main concentric regions: an inner cortex surrounded by an outer cuticle. In a small proportion of hairs, another innermost layer, the medulla, may be present [3]. Within the unit, there are 5–6 different subpopulations of melanocytes [11]. Melanogenically-active melanocytes are located at the infundibulum, sebaceous gland, and hair bulb around the dermal follicular papilla. Additionally, undifferentiated inactive melanocytes are located in the upper hair follicle reservoir near the arrector pili muscle insertion site, within the outer root sheath of the hair follicle, and in the hair bulb matrix [11]. Active melanocytes produce and transfer melanin to the keratinocytes of the hair shaft cortex, with a small amount also transferred to the medulla, and rarely to the cuticle [5]. The role of the inactive melanocytes is poorly understood, but they are thought to act as a stem cell reserve which can be induced to become melanin-producing cells if the skin is wounded [3, 5].

Hair melanogenesis is tightly linked to the stages of the hair cycle and is actively pigmented during anagen (growth) but not in catagen (involution) or telogen (quiescence) [4, 5]. Anagen for human scalp hair on average lasts 3.5 years, which requires the small population of follicular melanocytes to produce large amounts of melanin [12]. Follicle-based melanocytes are larger than epidermis-based melanocytes, with a more extensive Golgi apparatus and rough endoplasmic reticulum, thus producing larger melanosomes [13]. Follicular melanin also degrades more slowly than melanin in the epidermis. Because of this, the pigmentation at the distal and proximal ends of the hair shaft is similar [11]. The specific hair color is controlled by the type of melanin pigment produced by follicular melanocytes, including black-brown eumelanin and reddish-brown pheomelanin [4].

Numerous factors control stimulation of melanogenesis at the level of the hair follicle, including melanin-stimulating hormone, ACTH, endothelin-1, prostaglandins, leukotrienes, neutrophils, fibroblast growth factor, nitric oxide, and catecholamines [6]. In contrast, inhibitors of melanogenesis include sphingolipids, bone morphogenetic protein 4, and autoimmune processes (such as vitiligo and alopecia areata) [3, 4, 11, 14]. Certain compounds or diseases can affect the production of these factors and alter hair pigmentation. Conditions occasionally associated with darkening of hair color include Addison’s disease, neurodermatitis, porphyria cutanea tarda, and inflammatory scalp conditions [3, 15-17]. Conversely, conditions linked to hair lightening or graying include cystic fibrosis, celiac disease, hyperthyroidism/hypothyroidism, vitiligo, alopecia areata, and genetic diseases such as Werner syndrome, Louis-Bar syndrome, Waardenburg syndrome, or Griscelli syndrome [3, 14, 18, 19].

The development of gray hair is ultimately due to a decrease in the number of melanocytes. This can be either due to a defect in the melanocytic stem cells or destruction of the follicular stem cell population [3-5, 20]. A common issue leading to follicular melanocyte death is oxidative stress due to the development of reactive oxygen species (ROS) from hydrogen peroxide build-up (a natural product of the hair growth process) or ultraviolet (UV) light [3, 4, 20, 21]. Antioxidants such as Bcl-2, catalase, and methionine sulfoxide reductase are naturally produced by melanocytes to protect against ROS damage. These protective molecules are notably absent in gray hair follicles [20, 21]. For example, studies on BCL-2-deficient mice have noted the development of gray hair by the second hair cycle [20, 21]. Interestingly, melanocytes in the outer root sheath appear to be less affected by ROS damage, and they may be a pigment source for reversal of hair color [20]. Other causes of oxidative stress, including pollution, emotional stress, alcohol consumption, and cigarette smoking, have been linked to the premature development of gray hair [22, 23].

A systematic literature search was performed using PubMed and CINAHL ending in May 2019. The search terms were: (((grey OR gray) AND hair) OR canities OR achromotrichia) AND (treatment OR repigmentation OR reversal OR darkening OR therapy). All clinical trials, retrospective studies, case series, and case reports on gray hair and medication-induced color change in humans were included. Excluded were articles written in a language other than English; articles not about hair; review articles; and reports on patients starting with a hair color other than gray or white, or grey hair related to chronic nutritional deficiencies or diseases such as vitiligo or Griscelli syndrome. The quality of the evidence for each article was determined using the Oxford Centre for Evidence-Based Medicine criteria [24].

Two hundred and forty-one articles were evaluated and 27 were included in this systematic review. These consist of 4 prospective cohort studies, 3 retrospective cohort studies, 1 case series, and 19 case reports. This includes an aggregate of 133 patients with medication-induced gray hair repigmentation. Of these studies, 3 prospective studies and 1 case series focused specifically on premature hair graying, while the remaining articles investigated patients with age-related canities. Overall, the quality of the evidence is low, given that most cases were documented as solitary case reports, or in studies which were not reproducible. A summary of the articles and their level of evidence quality is found in Table 1.

The medications reported in the literature can be divided into five categories: anti-inflammatory medications (thalidomide, lenalidomide, adalimumab, acitretin, etretinate, prednisone, cyclosporin, cisplatinum, interferon-α, and psoralen), stimulators of melanogenesis (erlotinib, imatinib, latanoprost, tamoxifen, and levodopa), vitamins (calcium pantothenate and para-amino benzoic acid [PABA]), medications that accumulate in tissues (clofazimine), and those with a mechanism yet to be determined (captopril).

Psoralen plus UVA light (PUVA) was reported by Pavithran [25] to induce gray hair repigmentation directly in patients with premature gray hair. The author states that the idea stemmed from clinical experience while treating patients with PUVA for psoriasis. Because of this, a prospective study was performed specifically on healthy patients, aged 10–20 years, with premature gray hair (n = 37). After 13 months of treatment, 46% of these patients noted complete scalp hair repigmentation, with no relapse at the 8-month follow-up [25]. Seven additional patients showed partial repigmentation, with pigmented proximal ends of the gray hair shafts or repigmentation with a diffuse or patchy light-brown color [25].

The remaining cases of anti-inflammatory medications inducing gray hair repigmentation were noted in sporadic case reports. The retinoic acid receptor-activating medications acitretin and etretinate were associated with gray hair repigmentation in 2 patients with pityriasis rubra pilaris and 1 patient with psoriasis after 6–12 months of treatment [27-29]. A patient receiving interferon-α for the treatment of chronic hepatitis C described scalp hair repigmentation beginning 2 months after treatment, and persistent pigmentation after having discontinued the therapy [30]. Single case reports on a variety of other anti-inflammatory medications known to inhibit proinflammatory cytokine activity (including thalidomide, lenalidomide, adalimumab, cyclosporin, and prednisone) have also been linked to hair repigmentation after 2–24 months of treatment [31-37].

Five medications thought to stimulate melanogenesis were documented in 1 retrospective study and 6 case reports of hair repigmentation. In a retrospective study on patients receiving imatinib for chronic myeloid leukemia, 7% of 133 patients were reported to experience repigmentation of gray hair 2–14 months into treatment [38]. Another tyrosine kinase inhibitor, erlotinib, was also reported to induce progressive hair repigmentation 3 months and 2 years after treatment in 2 separate cases of patients with metastatic lung adenocarcinoma [39, 40]. One case of erlotinib-associated hair repigmentation began after an episode of folliculitis on the scalp [39].

A case of latanoprost eye drop use was connected with diffuse scalp hair repigmentation 3 years after having started a therapy for open-angle glaucoma [41]. Another patient reported scalp hair repigmentation 2.5 years after having started tamoxifen therapy for breast cancer [42]. Lastly, 2 patients receiving levodopa for Parkinson’s disease reported diffuse hair repigmentation within 8–9 months after having begun treatment [43, 44].

Studies of vitamin B supplementation with calcium pantothenate or potassium PABA are some of the earliest ones directed specifically at gray hair repigmentation. Successful repigmentation of premature gray hair in 2 healthy patients with high-dose calcium pantothenate (200 mg daily) was noted to begin as soon as 1 month after treatment [45]. A follow-up 3-year prospective cohort study of 7 women with premature gray hair, aged 12–31 years, reported that 28% of the patients noted repigmentation with 200 mg daily, while 28% noted repigmentation with 100 mg within 3 months [46]. One prospective cohort study and 1 retrospective study investigated the use of PABA for gray hair [47, 48]. In 1941, Sieve [47] performed the first documented study on repigmentation of gray hair on 50 patients with premature or age-related hair graying using PABA at 200 mg daily. He reported subjective marked hair darkening in all patients after 2 months of treatment. Another study investigated the effect of PABA at high doses (12–24 g/day) on age-related gray hair when used for the treatment of systemic diseases such as lymphoblastoma cutis, dermatomyositis, dermatitis herpetiformis, and scleroderma (n = 20) [48]. Thirty-five percent of the patients noted hair darkening after 2–10 months of treatment. Conversely, a prospective study on the use of 100 mg calcium pantothenate with 200 mg PABA daily for gray hair (27 subjects with age-related canities and 6 with premature graying) found 6% of the patients (all age-related graying) with a definite hair color change and 21% with a slight color change on clinical evaluation after 8 months of supplementation [49]. This study also noted that the repigmented hair returned to gray after supplement discontinuation.

Hair repigmentation with high-dose clofazimine during treatment of borderline lepromatous leprosy was noted as increased pigmentation of the skin initially, followed by hair repigmentation at 6 months of treatment. Increased skin pigmentation is a common side effect of clofazimine due to drug crystal accumulation in body tissues and fluids; however, it is not commonly reported to induce hair color darkening [50]. The hair repigmentation persisted for 8 months after having completed treatment.

As evidenced by the many cases of gray hair repigmentation in the literature, the development of gray hair may not be an irreversible process. The implication of hair pigmentation reversibility could have a noteworthy impact on the quality of life of a significant number of patients, and clinicians should be made aware of this. Most medications linked to repigmentation play an anti-inflammatory role, while fewer compounds affect melanogenesis, provide vitamin supplementation, or act on an unidentified target in the hair pigmentation process. While there are over 130 cases of medication-induced gray hair repigmentation reported in the literature, it is noteworthy that many of the medications mentioned have been used by millions of patients and only a small minority of patients have experienced hair repigmentation. This may be partially due to a lack of patients reporting hair color changes, but might more likely be due to the complex nature of hair follicle pigmentation regulation, which highlights that targeting one mechanism may not be enough to manipulate it.

Given that the data on gray hair repigmentation mainly stems from case reports, the overall quality of evidence is low. Because of this, the strongest data derive from prospective and retrospective cohort studies on PUVA, imatinib, and cisplatinum-based chemotherapy, as well as on the supplemental vitamins calcium pantothenate and PABA. Given the nature of these medications, their indication, and associated side effects, conducting trials with these toxic medications solely for the purpose of reversing hair color is prohibitive. Nonetheless, the information analyzed provides possible mechanisms of hair repigmentation that can be applied to new medications in the future, hopefully without similar adverse systemic effects.

The anti-inflammatory medications listed in this review inhibit proinflammatory cytokines. Adalimumab, thalidomide, and lenalidomide block tumor necrosis factor-α [52]. Similarly, cyclosporin inhibits the production and activity of IL-2. Acitretin and etretinate bind the retinoic acid receptor and inhibit expression of IL-6. Prednisone, psoralen, cisplatinum, and interferon-α have more generalized anti-inflammatory activities by decreasing immune cell activation and cytokine expression [52]. Proinflammatory cytokines such as tumor necrosis factor-α, IL-6, and IL-1 are known inhibitors of melanogenesis [6]. These cytokines are produced by many cells, including macrophages, which are located around the hair follicle in the perifollicular connective tissue sheath [53]. While the hair follicle is thought to be an area of immune privilege, aging melanocytes may play a role in increasing inflammation around the hair follicle bulb. Residual melanocytes in age-related graying hair bulbs are found to have blunted dendrites, defective melanosome transfer, and failure of precortical keratinocytes to receive melanin granules [5]. Defective compartmentalization of melanogenesis leads to accumulation of ROS and attracts inflammatory cells to the hair follicle [5]. The broken-down immune barrier of the hair follicle allows proinflammatory cytokines to access and further inhibit melanogenesis. It is possible that inhibition of these cytokines may break the feedback inhibition on hair pigmentation, allowing melanogenesis to resume.

While suppression of inflammation within the hair follicle appears to play a role in promoting repigmentation, the fact that hair repigmentation does not occur in 100% of patients treated with these medications signifies that repigmentation is a multifactorial process controlled by both inhibition of inflammatory cytokines and melanogenesis simulation. Medications such as psoralen, imatinib, erlotinib, latanoprost, tamoxifen, and levodopa are associated with stimulation of pigmentation. Prostaglandins such as latanoprost have previously been shown to cause periocular and iris hyperpigmentation when used for glaucoma [54]. In vivo studies have shown that PGF_2α analogs promote melanocyte dendricity and melanogenesis [55]. Similarly, estrogens increase skin and hair pigmentation by stimulating melanin release by melanocytes [56]. Tamoxifen, a selective estrogen receptor modulator, may act as an agonist in this process leading to increased pigmentation in rare cases. Furthermore, levodopa, a metabolite of melanin production, may also lead to hair pigmentation when circulating blood levels reach a certain threshold [52]. While we can hypothesize mechanisms for these medications to promote hair follicle repigmentation, the fact that there are only sporadic cases with the use of these commonly prescribed medications points to the fact that the process of hair repigmentation is not a simple one. Many of the solitary case reports could actually be coincidental timing of medication initiation and sporadic hair repigmentation instead of true causation. In the literature, there are reports of a 21-year-old male and a 67-year-old male with sporadic hair repigmentation without changes in medication or health status [57, 58]. Intermittent melanogenesis dysfunction may be related to a problem in the hair growth cycle, such as incomplete catagen signaling [57].

The cohort study on PUVA in patients with premature gray hair showed promising results. However, these findings may be due to the fact that patients with premature gray hair typically have a smaller percentage of gray hairs. Furthermore, the process of premature hair graying may be more amenable to reversal than age-related hair graying. As noted above, age-related gray hairs have defective melanocytes, which may not be as abundant in premature gray hair [5]. Nonetheless, psoralen may influence hair follicle pigmentation through multiple pathways. Its anti-inflammatory properties include alteration in cytokine and cytokine receptor expression, which may reduce inflammation and melanocyte destruction within the hair follicle. Furthermore, psoralen stimulates melanocyte proliferation and transfer of melanosomes to keratinocytes, which could lead to increased hair pigmentation [52].

Tyrosine kinase inhibitors such as imatinib and erlotinib also showed promise for repigmentation in the literature. A known side effect of these medications is folliculitis. Postinflammatory hyperpigmentation of the area may incite hair repigmentation in some cases. However, imatinib is also reported in the literature to cause hyperpigmentation of the oral mucosa, skin, and nails [59]. Imatinib inhibits c-Kit, which plays a key role in melanocyte homeostasis [59]. In vivo studies have shown that inhibition of c-Kit influences the number, size, and dendricity of melanocytes, which may influence hair pigmentation in rare cases [60].

Calcium pantothenate and PABA supplementation initially were studied to repigment hair having grayed due to specific vitamin deficiencies. Pantothenic acid (vitamin B5) deficiency is rare in the developed world and is unlikely to be the cause of gray hair in the USA [61]. While it is considered safe to take doses of up to 5 g/day, larger doses can cause diarrhea and abdominal pain. PABA, another member of the vitamin B complex family, has been reported to be useful in sclerotic skin disorders such as scleroderma, morphea, and Peyronie’s disease at doses up to 12 g/day without adverse effects [52]. Larger doses lead to an upset stomach, nausea, and hypoglycemia, which can be serious. While studies such as the cohort study by Sieve in 1941 noted impressive hair repigmentation, these trials have not been replicated or verified. With the validity of these studies in question, it is unlikely that vitamin supplementation truly impacts hair repigmentation in the absence of severe vitamin deficiencies. Due to the absence of more recent and repeatable data on vitamin supplementation for gray hair treatment, the use of these vitamins is not strongly supported solely for use for gray hair reversal.

Medications currently in development for gray hair repigmentation target both inhibition of inflammation and stimulation of melanogenesis. Harris [62] reports on a new combination compound, RT1640 (cyclosporin A, minoxidil, and a pigment-promoting drug), which induces gray hair repigmentation in a mouse model. An increase in pigmentation of gray mouse hairs was associated with increased melanocyte progenitor cell counts in up to 80% of hair bulbs. Furthermore, hair was shaved after treatment discontinuation and noted to regrow with continued repigmentation. Similarly, an α-melanin-stimulating hormone agonist, palmitoyl tetrapeptide-20, was found to preserve follicular melanocyte function and increase pigmentation during melanogenesis in a mouse model [63]. Saha et al. [64] describe the use of C18:0 sphingolipid-rich placental extract to induce microphthalmia-associated transcription factor (Mitf) and activate quiescent melanocyte stem cells in gray-haired mice. There was significant growth of dense black hair on mice treated with this extract, suggesting reactivation of melanocyte stem cells. Lastly, in a mouse model, flavonoids such as sterubin, luteolin, and hydroxygenkwanin have recently been shown to regenerate pigmented hair when applied during wound healing [65]. Flavonoids are antioxidants and anti-inflammatory compounds which scavenge free radicals and promote melanogenesis through the Wnt signaling pathway. As evident by many of these investigational treatments, inhibiting inflammation as well as promoting melanogenesis may be the key to hair repigmentation.

Gray hair is a natural course of aging; however, it may not be an inevitable or permanent process. Medications which target inflammatory cytokines, such as psoralen and cyclosporin, or stimulate melanogenesis, such as imatinib or latanoprost, have been reported to induce gray hair repigmentation in rare cases. While the evidence for these medications is of low quality, and the ability to effectively study them for gray hair treatment is difficult, their limited success sheds light on possible mechanisms to target for future development of hair repigmentation medications.

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Admittedly, I always had a fear of finding my first gray hair. Maybe it’s the way I’ve watched some of my family members go gray prematurely and stop at nothing to cover them, but I’ve always, wrongly, associated graying with “looking old.” At the ripe age of 30, I’ve now dealt with my fair share of silvery streaks, and after resorting to plucking them out (ouch?), I’ve finally decided to just let them be — but not without seeking other ways to slow the process down, first.

The reality is that going gray, like aging, is natural and inevitable, and for some, it can begin earlier than you might expect. In a world where words like “anti-aging” are still plastered all over beauty products, it’s understandable to freak out at the sight of your first stray gray, especially when it appears in your 20s or early 30s — but know that this is actually totally normal. In fact, while most people begin to gray between their mid-30s and 40s, it’s possible for others to start at just 20-years-old.

How you deal with your grays is entirely personal, whether you choose to embrace them full-on or cover them up. But for those, like me, who are looking to at least delay the process a bit, there are some preventative measures you can take. Studies have shown that lowering oxidative stress levels can be beneficial to those dealing with premature graying, and that doing so can help lower the rate at which new streaks crop up.

“There are a few main reasons hair turns gray — first and foremost, it is a result of aging,” says cosmetic dermatologist Dr. Michele Green. “As we age, the enzymes which are involved in oxidative stress, such as catalase and MSR A and B, do not work as efficiently as they do when we’re young. Ultimately, this leads to the overproduction of hydrogen peroxide, which then leads to the inhibition of melanin synthesis. As a result, there is less pigment in the hair.”

Green points out that due to the fact that graying is almost always the result of natural aging, there’s no real way to completely prevent it. “However, under not so common circumstances, gray hair may be the result of some illnesses such as a vitamin B12 deficiency, thyroid disorders, vitiligo, and alopecia areata,” she says. Additionally, NYC-based dermatologist Dr. Hadley King points out that, while the rate at which you age and therefore gray is largely determined by genetics (and looking into when your older family members started to go gray can be a good indicator), things like smoking, anemia, poor nutrition, and stress levels can also speed up the process.

“The process of graying is a multivariate equation and hypotheses abound,” says King. “It’s commonly thought that stress causes gray hair. Certainly stress cannot cause the hair to turn gray overnight, but it may accelerate the demise of melanocyte [cells that produce melanin, which pigments our hair] population. Stress hormones may impact the survival and/or activity of melanocytes, but no clear link has been established between stress and gray hair. They could cause inflammation that drives the production of free radicals, and it’s possible that these free radicals could influence melanin production.”

With the above in mind, can lowering oxidative stress levels through the factors you do have some control over help slow down graying? Trichologist Penny James of Penny James Salon thinks it’s possible, citing a 2020 study in which increased premature graying was not only linked to oxidative stress, but it was concluded that upping antioxidant intake is likely to yield some therapeutic benefits. But what’s the best way to approach this?

“Our bodies will naturally go under more oxidative stress as we age,” Green tells TZR. “To prevent any further oxidative stress, you can reduce your exposure to environmental stressors while limiting the consumption of foods that have higher rates of free radical production, such as red meats and grilled or charred foods.” She suggests instead opting for healthy fats, nuts, and avocados that are rich in vitamin E and vitamin C-rich foods such as berries, peppers, and citrus fruits.

Still, it’s important to keep in mind that most oxidative stress is inevitable. “Ultimately, these measures will not fully prevent the natural aging process of your hair, as oxidative stress occurs with natural aging,” says Green. “There’s nothing to be done to prevent the natural aging process, but lowering your oxidative stress may reduce any oxidative stress thereafter, potentially minimally reducing or slowing down the process in the long run.”

Opinions are mixed. While the study James cited concluded that supplements can be beneficial, King isn’t fully convinced. “In general, I would recommend a predominantly plant-based diet rich in antioxidants,” she says. “Studies about humans taking high doses or oral antioxidant supplements often end in increased morbidity and mortality, presumably because our bodies benefit in some ways from free radicals — our immune systems need free radicals to help kill cancer cells, for example. So, caution must be taken before translating these theoretical benefits to taking unproven supplements.”

However, James recommends two different supplements that may have promising effects: a vitamin B-complex and the amino acid L-tyrosine. “I do believe reducing our stress along with the intake of an L-tyrosine supplement and a vitamin B-complex can be of help and might stop more gray from appearing,” she says. “What these supplements will do is reduce the edema on the scalp along with reducing your internal stress levels. They’ll help keep your hair and scalp healthy along with improved blood flow and a much stronger, healthier hair bulb.”

She recommends the B Hair supplement by Hair Clinic (which can be ordered through her salon), since it also contains folic acid, biotin, vitamin C, zinc, magnesium in addition to B12 and B6. “All of these will nourish the hair root, increase density in the hair shaft, have a calming effect on your sympathetic nervous system along with boosting growth and preventing loss,” she says. Additionally, she recommends this B-Complex by Pure Encapsulations.

Hair wellness brand Arey recently launched its first product, Not Today, Grey, a daily supplement formulated with vitamins, minerals, antioxidants, and herbs to specifically address graying and delay the process, namely a powerful complex of B vitamins and the ancient herb fo-ti in addition to selenium, iron, and copper. While there’s no way to change genetics, the ingredients in Not Today, Grey work together to promote cell turnover, protect against free radicals, fuel melanin production, and improve the protein structure of the hair. Since they are so new, the experts couldn’t comment on whether or not they think taking these supplements would be an effective approach, but it’s an option worth exploring.

L-tyrosine, on the other hand, is an amino acid naturally found in the body that’s responsible for melanin production. In addition to helping to regulate thyroid function, taking an L-tyrosine supplement is thought to enhance mood and improve cognitive function, which is why James recommends it for addressing premature graying. “Taking an L-tyrosine supplement will reduce any inflammation, help reduce stress, and has been proven to help with hair loss,” she says. She recommends trying this L-tyrosine supplement from Pure Encapsulations.

Most experts say that no topical treatments to stop graying exist, though NYC dermatologist Dr. Joshua Zeichner believes that using shampoos containing zinc pyrithione may have some benefits. “Zinc pyrithione containing shampoos may have a variety of benefits for the scalp and the hair, as this ingredient has been shown in studies to provide antioxidant benefits and prevent UV light damage,” he says. These shampoos are typically used to treat dry and itchy scalps, dandruff, and conditions like seborrheic dermatitis. “They may help in addressing thinning hair, and while there is no good data to support this, I have my own theories that the use of these shampoos may minimize graying hair,” he says. So, while there are no guarantees, it’s another possible option to explore — just proceed with caution if you have color-treated hair, as this ingredient can potentially strip away dye.

Ultimately, combating oxidative stress may help slow down the process of graying, but there’s no way to completely prevent it (it is genetic after all) — and not all the experts are convinced it would yield dramatic results. All agree that the best approach is a natural one: eating a nutritious diet, reducing stress levels (hello, exercise, meditation, and sleep!), and avoiding smoking and exposure to environmental stressors like pollution as much as possible.

If you’re really concerned about your grays, it’s best to see a trichologist or dermatologist for other treatment, such as PRP (platelet rich plasma) treatment. “PRP is a great and effective way to stimulate the stem cells with our own growth factors, causing them to ‘wake up’ and grow,” says Green. “It will also ensure that all the right nutrients and sufficient blood flow is getting to the area, creating the perfect environment for catalase to function at its best, allowing the enzymes needed for hair color to work properly.” However, she points out that PRP should be seen as a preventative measure, as it would only have an effect on hair that still has pigment and has not already gone gray.

Other than that, you can turn to more temporary options for covering them with dye or makeup, or simply learn to love and embrace them. It’s inevitable that everyone’s hair will eventually go gray, and finding your first silvery streaks at a “younger” age is nothing to be ashamed of. Remember: With age comes wisdom, as well as wrinkles and grays, and that’s a reality that eventually everyone will have to face.

According to studies, premature greying is related to genetics [1]. It is likely that you will have grey hair at an early age if your mother or father had premature grey hair. It is also related to geography and race according to a study performed in 2013. People in a certain country can have grey hair much earlier than people in other countries. White people can get white hair even in their 20s, while Asian people most likely start getting white hair in their mid 20s. For African-Americans, the age of greying hair starts at 30.

Gray strands for any girl is a nightmare in reality. Each gray hair seems to scream – “old age is about to come and you will become an ugly, unattractive Baba Yaga!” Someone in a fit of fear begins to pluck out all suspicious elements with the meticulousness of a maniac, someone weekly “poison” scalp with a tint balm. But it is worth finding out – for what reason does the hair change its structure and turn gray? And the right way to get rid of frustrating gray hair ♥

This seems to be the easiest way to get rid of the annoying signs of aging .But not everything is so simple. First of all, in the long term it will not help, since the same gray hair will grow in the place of the removed hair. It could get worse. Yes, this will not result in gray hair in other places, but there may be some other difficulties. In particular, you can introduce infection and inflammation in the hair follicles.

Most often, graying of hair is a sign and a direct consequence of aging of the body. With age, the function of pigment-forming cells gradually decreases and the production of melanin stops. The time when this natural process begins is inherent in every person genetically.It is believed that in Caucasians, gray hair appears at about 34 years old (plus or minus 10 years), in Asians – at 30-34 years, and among representatives of the Negro ethnic group, the average age for the appearance of silvery hair is 43 years, plus or minus 10 years.

In some people, the graying process begins clearly prematurely, for example, at the age of 20 years in Caucasians and earlier than 30 years in Negroids.This can be both a consequence of a genetic predisposition, and the result of exposure to any external unfavorable factors or diseases of the body. For example, early graying can occur with anemia (anemia) or dysfunction (hyperfunction) of the thyroid gland.

There are also situations when, due to a lack of certain elements in the body, melanin ceases to be produced or retained on the protein of the hair shaft.There were also such cases in history when people turned gray in a very short period of time, most often due to very strong nervous tension or stress. This phenomenon can be explained by the fact that in stressful situations the body produces substances that disrupt the chemical bond that unites melanin and protein, as a result of which the pigment can quickly fall out, be washed out or neutralized.

Sometimes a change in hair color is taken for gray hair, which is a consequence of various diseases – for example, seborrhea, copper deficiency in the body, dysfunction of the thyroid gland (hypo- or hyperthyroidism).Improper hygiene procedures can also lead to a change in hair color. A woman who is not indifferent to her health, noticing that her hair began to lighten sharply, should consult a trichologist. The specialist will determine whether it is gray hair or a symptom of some kind of disease.

We must not forget about the prevention of various internal diseases. The fact is that the vessels on the head are closely intertwined, and, for example, bacteria that cause caries can easily enter the vessels that feed the hair.It is advisable to regularly visit a gastroenterologist, dentist, otolaryngologist. It is necessary to eliminate foci of infection on the head – such as chronic otitis media, tonsillitis, caries. It is important to timely treat inflammatory processes in the gastrointestinal tract and other body systems.

If your hair begins to fall out, and its condition has deteriorated significantly, there is no reason to do a short haircut.And although the problem with hair seems almost tragic to many, you can restore curls and restore their beauty. In this we are professionally encouraged by a dermatologist, a trichologist, a member of the RHRS, the Professional Society of Trichologists and the Union of Trichologists of Russia Elena Yarutkina . Let’s give the floor to the expert.

Vitamin D – one of the hair growth regulators (the hair follicle has receptors for it), participates in the process of differentiation of hair follicle cells. The production of the vitamin occurs in the upper layers of the skin of the waters by exposure to ultraviolet radiation. It is important to remember that almost all over the world (and even in countries with a year-round sun) there is a deficiency of this essential vitamin-prohormone.Therefore, vitamin D is perhaps the only supplement that needs to be taken on an ongoing basis under the control of analyzes.

The protective layer of skin and hair consists of lipid complexes – ceramides, sterols, phospholipids, fatty acids. The lack of fat in the diet cannot provide the usefulness of the protective lipid layer of the skin, due to which the hair loses moisture, the condition of the hair follicle deteriorates, which leads to loss. From fats, we also obtain valuable omega-3 fatty acids: eicosapentaenoic (EPA) and docosahexaenoic (DHA). For the scalp and hair, these are good anti-inflammatories.Therefore, it is recommended to include fatty fish (salmon, halibut, herring, sardine) in the diet 2-3 times a week or get omega-3 from supplements.

But carbohydrates in the diet should be limited. First of all, this applies to simple carbohydrates obtained by an industrial method: sweets, baked goods. Abuse of them leads to increased oiliness of the scalp and the fact that hair falls out a lot. To normalize carbohydrate metabolism and with the concomitant loss of curls, the following additives are shown: taurine, alpha-lipoic acid, berberine, chromium, manganese, zinc, biotin.

This diagnostic method was popular in the 90s. To date, it is almost never used in progressive trichology. Numerous studies have shown the inconsistency of the method: often the level of some element in the hair is high, while its deficiency is found in the blood.And vice versa. In addition, the analysis is not able to establish whether the content of elements in the hair is associated with processes in the body or with environmental factors. Meanwhile, the balance of minerals can vary depending on the color, thickness and rate of hair growth, as well as on age and gender, on the season and geographic location, and on cosmetics.

On the one hand, complex vitamins are very convenient: they have everything you need for hair loss.But often the dosages of vitamins and minerals in complex supplements significantly exceed the daily norms (sometimes dozens of times!) Or, conversely, do not replenish them. Differences in assimilation cannot be discounted. So, vitamins C and B6 are less absorbed from vitamin-mineral complexes in comparison with monocomponent preparations. In addition, complex supplements sometimes contain iodine, which is contraindicated in some thyroid diseases.

I am for a reasonable approach and targeted assistance to the body. To begin with, it is worth checking the hair and taking a blood test, and then selecting supplements to fill deficiencies, taking into account synergy (strengthening of each other’s action) and antagonism (incompatibility) of active substances. For comparison: iron is better absorbed when taken together with vitamin C, copper, manganese and group B drugs, and is less absorbed when taken together with zinc or calcium.

The most important thing for a doctor before an examination is anamnesis (medical history). A thoroughly collected anamnesis allows one to suspect the causes of the loss (genetics, stress, medication, deficiencies, hormonal disorders, etc.) and avoid unnecessary examination. Further, trichoscopy, phototrichogram are important – these methods make it possible to understand the type of loss.And only then analyzes take place in trichology.

There are also parenteral forms of drugs – intravenous and intramuscular injections. They give a quick effect: in a matter of minutes, the active substance enters the bloodstream and begins to work.But the use of injections is limited and justified only in a number of cases: the need to quickly fill deficiencies, with intolerance to enteral drugs, in the presence of active inflammatory bowel diseases, when the pill simply cannot be absorbed. Naturally, only a doctor can prescribe injectable forms.

According to trichologists, the best vitamins that can be taken by those experiencing hair loss are bioavailable folate (5-L methyltetrahydrofolate), but not folic acid (B9).Methylcobalamin (methyl B12) is indicated for replenishing a B12 deficiency, rather than cyanocobalamin, which is less well absorbed. This also applies to vitamin B6: choose pyridoxal-5′-phosphate (PLP or P-5′-P) over pyridoxine hydrochloride.

Of the complex preparations, the good ones are RidgeCrest Herbals Hair ReVive, NOW Solutions Vegan Hair, Skin & Nails, Famvital. However, I still have not found a single complex with an ideal composition, which I could confidently deign with an enthusiastic review from a trichologist. The vast majority leave much to be desired. This is another argument in favor of taking monocomponent vitamins and minerals with quality forms.

From prenatal complexes, Thorne Research Basic Prenatal, Garden of Life mykind Organics Prenatal Multi, Emerald Labs Prenatal have a good composition.These vitamins for pregnant women, for hair growth of non-pregnant women are equally suitable. The listed complexes can be taken both at the planning stage of maternity and during feeding, since they contain all the necessary vitamins and minerals for the active work of the hair follicle.

– Exclude anemia (iron deficiency, vitamin B12 deficiency) To do this, you need to do a blood test for the level of hemoglobin, iron, ferritin (the main element that is the cause of latent anemia, even with normal hemoglobin levels) and vitamin B12
– To identify abnormalities in the thyroid gland, to be tested for thyroid hormones, the level of vitamin D3, which affects not only the absorption of calcium, but also the hormonal background.
– Disorders in the gastrointestinal tract, dysbiosis (after a course of antibiotics, chemotherapy). Restore the work of the digestive tract with lacto and bifido bacteria.
– Stress, hormonal disruptions (hormone imbalance, cancellation of OC, menopause, HS)

Hair loss due to HS is the most common problem, but this is an absolutely normal physiological process. During pregnancy, the hormonal background changes, the hair practically ceases to fall out. Childbirth is a kind of stress to the body, plus a changed hormonal background – the hair begins to crawl in “bundles” just 3-6 months after childbirth.This is fine. Then a new coat will climb 🙂

There are 2 problems: not all drugs can be taken with hepatitis B and not all of them will be effective due to the hormonal cause of the loss. You can only slightly improve the situation with external masks, sprays, taking prenatal and postnatal vitamins. There are no special complexes for HV loss, you can only consult with your doctor which ones you can take.
I will tell you a secret that not a single manufacturer will write that the product can be consumed by hepatitis B or pregnant women, simply because no one is conducting experiments.Therefore, some supplements are drunk on their own responsibility.
But the problem will be finally solved only after the completion of hepatitis B, when the body returns to normal.

For more information, consult a trichologist who examines the hair and scalp under a microscope. The main thing here is to find a good specialist, since often trichologists promote products of a brand or skip to expensive procedures. Like it was with me. At the age of 26, the trichologist prescribed me a course of plasmolifting, without even checking my analyzes.I did not trust the opinion of such a “doctor” and rather quickly solved my problem with the help of supplements.

I have previously taken vitamins to reduce hair loss, I noticed a good effect in terms of reducing hair loss, increasing hair volume and growth. The longest course was six months, my review can be read HERE
But by nature, having thin hair, I never believed that you can get a wow effect with the help of additives and deceive nature a little.
After talking with my master, I was finally convinced that it is very possible.Now I am aiming for a long course of at least a year in order to improve the structure, increase the density and grow the desired hair length.

Separately, I would like to note biotin . This element is produced in the body on its own, but is destroyed under the influence of various factors. In the body of a pregnant woman, its maximum amount, so the hair during pregnancy twig and shine like never before.
The intake of biotin brings good results to many, it does not give anything to some, but I will say one thing: everyone’s favorite dosage of biotin 10.000mg is excessive and can negatively affect the results of some tests.It is recommended to take biotin at a dosage of 5000mg along with other B vitamins.
By the way, biotin is the main complement of the popular Sugar Bear Hair vitamins, which contain very, very little of it.

Sulfur – in additions usually comes in the form of methylsulfonyl methane or MSM . It has a positive effect on the hair structure, elasticity, helps the absorption of B vitamins
Keratin is a building material for hair, usually obtained from animal hair.
Calcium – Important for the formation of strong bones and for the strength of skin, hair and nails. It is recommended to take it with vitamin D3 for proper absorption.
Zinc is a building material, an element that affects all processes in the body, zinc deficiency affects the health of hair, skin and nails, therefore zinc is part of almost all hair complexes

Amino acids- irreplaceable helpers for protein synthesis, which do their job gently and responsibly without disrupting the work of other organs.
L-Cysteine  – good for hair structure, liver and brain detoxifier. It is part of the famous Pantovigar, but in a lower dosage.
Proline, Lysine, Glycine are also important for the formation of the hair shaft. They are usually included in the complex in the form of protein

One of the most popular and effective complexes on Iherb. Contains vitamin C, zinc, copper, silicon, amino acids l-proline and l-lysine.The main focus here is on the Opti-MSM complex or methylsulfonyl methane, which has a good effect on the hair structure, making it dense, giving strength to new hair. Since there are no B vitamins, this complex is recommended to be taken with multivitamins or with a B-complex

Perhaps the most popular vitamin complex, which I simply cannot ignore. I will not accept it) Personally, it did not suit me, I wrote about this HERE . But for many people it is great and solves the problem of hair loss, new hair growth and improvement of their structure.
The complex also contains B vitamins in high dosages, silicon, sulfur, copper, inositol, choline, l-cysteine, horsetail extract and para-aminobenzoic acid
The complex is undoubtedly effective, but too heavy for the body and has a number of common side effects (heartburn, change body odor, stress on the kidneys, subcutaneous acne, etc.)

Keratin complex with additives to increase hair density. Additionally, there are collagen types 1 and 3, biotin at a dosage of 50% of the daily value, Amla or Indian gooseberry extract, which is effectively used to treat hair loss according to Ayurveda.There is also protein, which means amino acids.
The complex has a very good effect on the hair structure, gives strength to new vellus hairs. It is recommended to alternate it with the MSM complex.
There are also more than powerful keratin with biotin and resveratrol, in a double dosage, but it is also more expensive and often not available

Now I take Solgar and Keratin , 2 capsules for 3 months, I also drink collagen
Then I will start the course New Nordic – capsule per day 3 months
Then RidgeCrest Herbals – 2 capsules for 2 months, maybe add MSM sulfur separately
for the next 2 months Hair Renew + Keratin , according to instructions
I will evaluate the effect and again into battle
Throughout this time, I will take omega-3 and collagen as usual , alternating it with biosil.How to choose and take collagen wrote HERE

Also, the child’s body must receive a number of vitamins and minerals. It is vitamins A, B, C, E that restore hair structure and accelerate the production of melanin. It is also helpful to give your child fresh fruits and berries. You can treat the curls with fresh juice from vegetables and berries. How is the treatment of hair loss in women with vitamins is described in detail in this article.

Hair color is determined by the level of melanin (the higher it is, the darker the hair) depends on genetic and endocrine factors. Also, the amount of dye – pigment (black-brown and yellow-red) affects hair color.Their ratio is individual for each person, so we all have a different shade of hair. Over time, the activity of the pigment-producing cells decreases, the hair grows uncolored, that is, gray.

Aging of hair is associated with changes in hormonal levels. Usually, after 45 years, the level of estrogens decreases, which control the biological cycles of the body in general and skin and hair cells in particular.Because of this, hair growth slows down, and hair loss is not compensated by the growth of new ones. But recent research shows that this is not at all indicative of weakness or extinction!

Early gray hair can be associated with thyroid dysfunction, and this is a common consequence of iodine deficiency. If the cause is eliminated, the gray hair recedes and the natural hair color is restored. Iodine deficiency is almost always accompanied by a deficiency of selenium – our main “anti-aging”. And in the end, the conclusion follows: if you want to be and look young, replenish the supply of trace elements.

Hair pigmentation also depends on the presence of B vitamins: vitamin B6, folic and pantothenic acids. Sulfur, which is part of the sulfur-containing proteins cysteine and methionine, gives the hair a beautiful shine. Omega-3 fatty acid deficiency is one of the causes of hair follicle death, stunted hair growth and hair loss, so unsaturated fatty acids are generally beneficial for healthy hair.

One of the most unpleasant results of a modern lifestyle is gray hair.Nothing matches the horror you feel at the first gray hair. You know there will be more, and you are looking for remedies and treatments that can stop the inevitable. The appearance of gray hair in old age is obvious. But when you notice them at 30 or even 20 years old, it is very sad. Both gray and white hair are the result of your hair losing its pigment. When there is a significant reduction in pigment, the hair turns gray. When there is no pigment, the hair becomes white.The exact reason for this remains to be seen, but here are some tips from MedicForum to help you cut down on pure gray hair to a minimum.

1. Genetics This is the predominant factor in determining at what age your hair loses its pigment. For some people, this can happen even before they turn 20. For others, the first white streaks appear rather late.2. Melanin deficiency In most cases, a lack of melanin is the main cause of hair bleaching. Melanin production depends on adequate nutrition and protein supplementation. The lack of these nutrients causes melanin to fall below acceptable levels. 3. Hormones Your hormones have a huge impact on the pigmentation of your hair. An imbalance can cause your hair to turn white. 4. Medical Problems Some major medical problems can cause loss of pigment in the hair.These include vitamin B12 deficiency or thyroid and pituitary gland problems. 5. Stress Stress caused by a tight schedule is a major cause of premature gray hair, as well as excessive consumption of alcohol and unhealthy food. 6. Chemicals Sometimes the cause of early gray hair can be the use of chemical shampoos, soaps, hair dyes, etc. However, this can be due to some allergic reactions. 7. External factors Changes in hair color can occur due to external factors such as climate, pollution and exposure to certain chemicals.These factors accelerate the aging process.

The ability to change the color of the hair so that the white hair turns black depends to a large extent on the cause of the gray hair.If genetics are responsible, there is little that can be done to reverse the change. If an underlying health problem is the cause, see your doctor to find out what you can do about it. Once the problem is resolved, it can help restore the pigment in your hair. However, this cannot be guaranteed. Re-pigmentation is sometimes possible after hormone therapy. Vitamin B-12 tablets are another way to promote pigmentation. 1. Oil for White Hair Boil gooseberries with coconut oil to make an oil solution.Store this oil in a jar and take about 2 tablespoons for each use. Massage two tablespoons of the oil into your scalp and work the length of your hair. Leave the oil on for another 30 minutes after the massage. Alternatively, you can leave the oil on overnight. Wash off with mild sulfate-free shampoo and finish with conditioner. Gooseberry repairs damaged hair. It also works as a hair tonic to help give dark hair a shiny shine. It has a rich supply of vitamin C, which is an antioxidant that has anti-aging benefits and repairs pigment in hair follicles.You can also soak dry berries in water overnight and rinse your hair the next morning with this water. Alternatively, mix dried gooseberry powder with lemon and almond oil for a smooth blend that can be applied regularly to your scalp. 2. Black tea for gray hair Boil black tea in a cup of water to brew well. Let it cool down. After cooling, strain the liquid and apply it to your hair and scalp. Massage your scalp for a couple of minutes and wait about an hour with the tea in your hair.Wash your hair with a mild sulfate-free shampoo and finish with conditioner. Black tea replenishes hair with antioxidants and helps suppress white hair growth. It also helps darken hair color while adding shine.

3. Curry Leaves for White Hair Boil curry leaves with coconut oil to make an oil solution. Leave the oil to cool. Once it has cooled, strain the oil and massage it into the scalp and distribute it along the length of the hair. After massaging for about 15 minutes, leave the oil on for another 30 minutes.Alternatively, you can leave the oil on overnight. Wash off with a mild sulfate-free shampoo and finish with conditioner. Curry leaves help restore the melanin pigment in hair follicles. It is also a rich source of vitamin B, which is vital for hair growth. 4. Coconut oil and lemon juice for white hair Pour the lemon juice into the coconut oil and heat the mixture for a couple of seconds. Massage this mixture. Leave it on for 30 minutes. Wash your hair with a mild sulfate-free shampoo and finish with conditioner.Lemon contains vitamins B and C and is also a rich source of mineral phosphorus. They are vital for maintaining the pigment cells in your hair follicles. 5. Castor oil with mustard oil for white hair Combine the oils and heat the mixture for a couple of minutes until it becomes slightly warm. Apply the oil mixture to your scalp. After massaging the scalp for about 15 minutes, leave it on for another 30 minutes. Wash your hair with a mild sulfate-free shampoo and finish with conditioner.

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Gray Hair Reversal: Vitamins And Supplements

What Causes The Hair To Turn Gray?

1. Vitamin Deficiencies

2. Genetics

3. Medical Conditions

4. Stress

5. Smoking

6. Chemical Hair Dyes And Products

7. Pollution And UV Exposure

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The Takeaway

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Vitamins to REVERSE GREY HAIR

Vitamin B12, Vitamin B9, Vitamin B7, Vitamin B6, Vitamin B3

Vitamin D

Vitamin E

Vitamin C

Zinc & Copper

Iron

Magnesium

Catalase Enzyme

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Top 10 Best Vitamins For Gray Hairs 2020

1. HAIRFLUENCE – Hair Growth Formula For Longer, Stronger, Healthier Hair – Scientifically Formulated

2. Biotin Shampoo For Hair Loss – Extra Strength Hair Growth Treatment – Natural

3. BEARD GAINS No More Gray Beard Hairs Vitamin, Stop Premature Grey or White

4. Biotin Growth Support Vitamins- Grow Longer, Fuller, Thicker, Healthier Hair, Nails & Skin

5. HairAnew (Unique Hair Growth Vitamins with Biotin) – Tested – for Hair, Skin

6. Gray Hair Rescind by Life Vitality Makes Gray Hair Go Away, 60 caps

8.

10. FoliGROWTH Ultimate Hair Nutraceutical – Get Thicker Hair, Reverse Diffuse Thinning Guaranteed

Medication-Induced Repigmentation of Gray Hair: A Systematic Review – FullText – Skin Appendage Disorders 2020, Vol. 6, No. 1

Abstract

Introduction

Clinical Presentation

Pathophysiology

Methods

Results

Table 1.

Anti-Inflammatory Medications

Stimulators of Melanogenesis

Vitamin Supplementation

Accumulation in Tissues

Unknown Etiology

Discussion

Conclusions

Disclosure Statement

Funding Sources

References

Author Contacts

Article / Publication Details

Copyright / Drug Dosage / Disclaimer

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