What are the common side effects of Lipitor. How can patients manage potential risks while taking atorvastatin. Is weight gain a concern for those prescribed Lipitor. What should you know about muscle pain and liver damage risks.

Understanding Lipitor and Its Uses

Lipitor, known generically as atorvastatin, is a widely prescribed medication used to treat high cholesterol and reduce certain cardiovascular risks. As a member of the statin drug class, Lipitor works by inhibiting an enzyme involved in cholesterol production in the liver. This helps lower levels of LDL (“bad”) cholesterol and triglycerides while potentially raising HDL (“good”) cholesterol.

Doctors typically prescribe Lipitor in conjunction with lifestyle modifications such as a heart-healthy diet and regular exercise. The medication is approved for use in adults and some children to:

• Lower cholesterol levels
• Reduce the risk of heart attack, stroke, and certain heart procedures in patients with multiple risk factors
• Treat patients with existing coronary heart disease to lower the risk of heart attack, stroke, and cardiac events

Lipitor comes as a tablet taken orally, usually once daily. Available dosages include 10 mg, 20 mg, 40 mg, and 80 mg strengths. The appropriate dose is determined by a healthcare provider based on individual patient factors and treatment goals.

Common Side Effects of Lipitor

While Lipitor is generally well-tolerated, it can cause side effects in some patients. Understanding these potential adverse effects is crucial for patients to recognize issues and seek appropriate medical attention if needed. Common side effects reported with Lipitor use include:

• Infections (e.g., common cold, urinary tract infections)
• Nausea
• Pain in arms or legs
• Joint pain
• Diarrhea
• Mild muscle pain

Are these side effects typically long-lasting? In most cases, these common side effects are temporary and may resolve on their own as the body adjusts to the medication. However, if any symptoms persist or become bothersome, it’s important to consult with a healthcare provider. They can assess whether dosage adjustments or other interventions may be necessary.

Serious Side Effects and Risks

While less common, Lipitor can potentially cause more serious adverse effects that require immediate medical attention. These include:

• Severe muscle pain or weakness
• Rhabdomyolysis (breakdown of muscle tissue)
• Immune-mediated necrotizing myopathy (a rare muscle condition)
• Liver damage
• Severe allergic reactions

How can patients recognize signs of these serious side effects? Symptoms that may indicate a severe reaction include:

• Unexplained muscle pain, tenderness, or weakness
• Dark-colored urine
• Yellowing of the skin or eyes (jaundice)
• Unusual fatigue or weakness
• Loss of appetite
• Upper stomach pain
• Flu-like symptoms

If any of these symptoms occur, it’s crucial to seek immediate medical care. Prompt intervention can help prevent complications and determine whether Lipitor should be discontinued or the treatment plan adjusted.

Managing Muscle-Related Side Effects

Muscle pain and weakness are among the most commonly reported side effects of statins like Lipitor. While often mild, in rare cases these symptoms can indicate a more serious condition.

Can muscle pain from Lipitor be managed? In many cases, yes. Strategies may include:

• Dose adjustment: Lowering the Lipitor dose may help alleviate symptoms in some patients.
• CoQ10 supplementation: Some studies suggest coenzyme Q10 supplements may help reduce statin-related muscle pain, though more research is needed.
• Exercise modifications: Gradually increasing physical activity and avoiding sudden intense workouts may help minimize muscle discomfort.
• Adequate hydration: Staying well-hydrated can support muscle health and potentially reduce pain.

It’s essential to communicate any muscle symptoms to your healthcare provider. They can determine if the pain is likely related to Lipitor and recommend appropriate management strategies or alternative treatments if necessary.

Liver Health and Lipitor

Lipitor and other statins can potentially affect liver function. While serious liver damage is rare, monitoring liver health is an important aspect of Lipitor treatment.

How is liver health monitored in patients taking Lipitor? Doctors typically order liver function tests before starting Lipitor and periodically during treatment. These blood tests measure levels of certain enzymes that can indicate liver stress or damage.

To support liver health while taking Lipitor, patients should:

• Avoid excessive alcohol consumption
• Maintain a healthy diet rich in fruits, vegetables, and whole grains
• Exercise regularly
• Inform their doctor of all medications and supplements they’re taking, as some may interact with Lipitor and affect the liver

If liver function tests show elevated enzyme levels or if symptoms of liver problems develop, the healthcare provider may adjust the Lipitor dose or consider alternative treatments.

Lipitor and Diabetes Risk

Research has identified a small increased risk of developing type 2 diabetes in patients taking statins like Lipitor. This risk appears to be higher in certain groups, including older adults and those with existing risk factors for diabetes.

Does this mean patients should avoid Lipitor if they’re at risk for diabetes? Not necessarily. The cardiovascular benefits of Lipitor often outweigh the small increased diabetes risk for many patients. However, it’s important to discuss individual risk factors with a healthcare provider.

For patients taking Lipitor, especially those at higher risk for diabetes, monitoring blood sugar levels is crucial. Lifestyle measures such as maintaining a healthy weight, following a balanced diet, and engaging in regular physical activity can help mitigate diabetes risk.

Addressing Concerns About Weight Gain

Weight gain is not typically listed as a common side effect of Lipitor in clinical studies. However, some patients report experiencing weight changes while taking the medication.

Is weight gain a direct side effect of Lipitor? The relationship between Lipitor and weight gain is complex. Several factors may contribute to weight changes in patients taking statins:

• Reduced physical activity due to muscle pain or fatigue
• Changes in diet or lifestyle habits
• Age-related metabolic changes
• Other medications or health conditions

If weight gain occurs while taking Lipitor, it’s important to discuss this with a healthcare provider. They can help determine if the weight change is related to the medication or other factors and recommend appropriate strategies to manage weight.

To maintain a healthy weight while taking Lipitor, patients should:

• Follow a balanced, calorie-appropriate diet
• Engage in regular physical activity as tolerated
• Monitor portion sizes and keep a food diary if needed
• Seek support from a registered dietitian if significant dietary changes are necessary

Drug Interactions and Lipitor Side Effects

Lipitor can interact with various medications and substances, potentially increasing the risk of side effects or reducing the drug’s effectiveness. Understanding these interactions is crucial for safe and effective treatment.

What types of drugs may interact with Lipitor? Common interactions include:

• Other cholesterol-lowering medications (e.g., fibrates, niacin)
• Certain antibiotics and antifungal medications
• Some HIV medications
• Cyclosporine (an immunosuppressant)
• Certain heart medications (e.g., digoxin, amiodarone)
• Grapefruit juice

To minimize the risk of interactions, patients should:

• Provide a complete list of all medications, supplements, and herbal products to their healthcare provider
• Avoid consuming large amounts of grapefruit or grapefruit juice
• Consult with a pharmacist or doctor before starting any new medications or supplements
• Never adjust their Lipitor dose or stop taking the medication without medical guidance

Healthcare providers may need to adjust dosages or recommend alternative treatments if significant drug interactions are identified.

Managing Side Effects Through Lifestyle Modifications

While medication management is crucial, lifestyle factors can play a significant role in minimizing side effects and optimizing Lipitor treatment. Patients can take several steps to support their overall health and potentially reduce the risk of adverse effects:

1. Maintain a heart-healthy diet:
   • Emphasize fruits, vegetables, whole grains, and lean proteins
   • Limit saturated fats, trans fats, and cholesterol
   • Incorporate omega-3 fatty acids from sources like fatty fish or plant-based options
2. Stay physically active:
   • Aim for at least 150 minutes of moderate-intensity aerobic activity per week
   • Include strength training exercises 2-3 times per week
   • Start slowly and gradually increase intensity to avoid muscle strain
3. Manage stress:
   • Practice relaxation techniques such as deep breathing or meditation
   • Engage in stress-reducing activities like yoga or tai chi
   • Seek support from friends, family, or a mental health professional if needed
4. Get adequate sleep:
   • Aim for 7-9 hours of quality sleep per night
   • Establish a consistent sleep schedule
   • Create a relaxing bedtime routine
5. Stay hydrated:
   • Drink plenty of water throughout the day
   • Limit alcohol consumption
   • Monitor caffeine intake, especially if it affects sleep

By incorporating these lifestyle modifications, patients may improve their overall health, potentially enhance the effectiveness of Lipitor, and reduce the likelihood of experiencing certain side effects.

The Importance of Regular Monitoring and Follow-up

Ongoing medical supervision is essential for patients taking Lipitor to ensure the medication’s effectiveness and monitor for potential side effects. Regular check-ups and laboratory tests allow healthcare providers to assess treatment progress and make necessary adjustments.

What should patients expect during follow-up appointments? Typical monitoring may include:

• Lipid panel tests to measure cholesterol levels
• Liver function tests
• Muscle enzyme (CK) tests if muscle symptoms occur
• Blood glucose monitoring, especially for patients at risk of diabetes
• Blood pressure checks
• Discussion of any side effects or concerns

Patients should prepare for these appointments by:

• Keeping a record of any symptoms or side effects experienced
• Noting any changes in other medications or supplements
• Preparing questions about their treatment or concerns
• Bringing a list of current medications and dosages

Open communication with healthcare providers is crucial. Patients should feel comfortable discussing any issues or concerns related to their Lipitor treatment, as this information helps guide optimal care and management of potential side effects.

Alternative Treatments and Lipitor

While Lipitor is an effective medication for many patients, some individuals may not tolerate it well or may prefer to explore alternative treatments. It’s important to discuss options with a healthcare provider before making any changes to a prescribed treatment plan.

What alternatives might be considered for patients who cannot take Lipitor? Options may include:

• Other statin medications (e.g., rosuvastatin, pravastatin)
• Non-statin cholesterol-lowering drugs (e.g., ezetimibe, PCSK9 inhibitors)
• Bile acid sequestrants
• Fibrates
• Niacin
• Omega-3 fatty acid supplements

In some cases, a combination of different medications may be recommended to achieve cholesterol-lowering goals while minimizing side effects. Additionally, intensive lifestyle modifications may be sufficient for some patients with mild to moderate cholesterol elevations.

It’s crucial to work closely with a healthcare provider to determine the most appropriate treatment approach based on individual health status, risk factors, and personal preferences.

Understanding the Long-term Benefits and Risks of Lipitor

When considering Lipitor treatment, it’s important to weigh the potential long-term benefits against the risks of side effects. Numerous studies have demonstrated the effectiveness of statins like Lipitor in reducing cardiovascular events and mortality in at-risk populations.

What are the long-term benefits of taking Lipitor? Research has shown that consistent statin use can lead to:

• Significant reductions in LDL cholesterol levels
• Decreased risk of heart attack and stroke
• Reduced need for coronary revascularization procedures
• Potential slowing of atherosclerosis progression
• Improved overall cardiovascular outcomes

While the risk of side effects is real, for many patients, the cardiovascular benefits of Lipitor outweigh the potential risks. However, individual risk-benefit analysis is crucial, and treatment decisions should be made in consultation with a healthcare provider.

Long-term use of Lipitor requires ongoing monitoring and periodic reassessment of treatment goals. As patients age or their health status changes, the balance of benefits and risks may shift, necessitating adjustments to the treatment plan.

Empowering Patients: Education and Self-Advocacy

Patient education plays a vital role in the successful management of Lipitor treatment and potential side effects. Informed patients are better equipped to recognize issues, communicate effectively with their healthcare team, and make decisions about their care.

How can patients become more informed about their Lipitor treatment? Strategies include:

• Asking questions during medical appointments
• Researching reputable sources for information about Lipitor and cholesterol management
• Joining support groups or online communities for patients with similar conditions
• Attending educational seminars or workshops on heart health
• Utilizing resources provided by healthcare institutions or pharmaceutical companies

Patients should feel empowered to advocate for their health by:

• Discussing concerns openly with their healthcare provider
• Requesting explanations of test results and treatment recommendations
• Seeking second opinions when appropriate
• Participating actively in treatment decisions

By taking an active role in their care, patients can work collaboratively with their healthcare team to optimize Lipitor treatment while minimizing the risk of side effects.

Lipitor Side Effects and How to Manage Them

Lipitor (atorvastatin) is a prescription drug that’s used to treat high cholesterol and reduce certain heart risks. Lipitor can cause side effects, also called adverse effects, that range from mild to serious. Examples include muscle pain and liver damage.

Lipitor is used along with diet and exercise to:

• lower cholesterol levels in adults and some children
• reduce other heart risks in adults with high cholesterol

The active ingredient in Lipitor is atorvastatin. (An active ingredient is what makes a drug work.) The drug comes as a tablet that you swallow.

Keep reading to learn about the common, mild, and serious side effects that Lipitor can cause. For a general overview of the drug, including details about its uses, see this article.

Some people may experience mild to serious side effects during Lipitor treatment. Examples of Lipitor’s commonly reported side effects include:

• infections, such as the common cold or urinary tract infection (UTI)
• nausea
• pain in your arms or legs
• joint pain*
• diarrhea*

* To learn more about this side effect, see the “Side effects explained” section below.

Examples of mild side effects that have been reported with Lipitor include:

• infections, such as the common cold or urinary tract infection (UTI)
• pain in the legs or arms
• nausea
• mild muscle pain*
• joint pain*
• diarrhea*
• mild allergic reaction*

* To learn more about this side effect, see the “Side effects explained” section below.

In most cases, these side effects are temporary. And some may be easily managed. But if you have any symptoms that are ongoing or bother you, talk with your doctor or pharmacist. And, do not stop taking Lipitor unless your doctor recommends it.

Lipitor may cause mild side effects other than the ones listed above. See the drug’s prescribing information for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Lipitor, visit MedWatch.

Serious side effects that have been reported with Lipitor include:

• serious muscle pain
• rhabdomyolysis, a serious condition caused by the breakdown of muscle
• immune-mediated necrotizing myopathy, a rare muscle condition
• liver damage*
• severe allergic reaction*†

* To learn more about this side effect, see the “Side effects explained” section below.
† An allergic reaction is possible after using Lipitor. But it’s unclear whether this side effect occurred in studies.

If you develop serious side effects while taking Lipitor, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Get answers to some frequently asked questions about Lipitor’s side effects.

Do Lipitor and atorvastatin (generic name for Lipitor) have similar side effects?

Yes. Lipitor and its generic version, atorvastatin, typically have the same side effects. Both drugs contain the same active ingredient, which is atorvastatin. An active ingredient is what makes a drug work.

But the inactive ingredients in Lipitor and atorvastatin may be different. So it’s possible to have different side effects due to the inactive ingredients in these drugs.

If you’re interested in switching between the brand-name and generic forms of Lipitor, talk with your doctor or pharmacist. They can discuss with you possible differences in the generic’s side effects compared with Lipitor’s.

Is there any difference between the side effects Lipitor may cause in females and males?

No, Lipitor should not cause different side effects in females and males.* In studies of Lipitor, there weren’t differences in side effects in men compared with side effects in women.

It’s important to note that doctors may not prescribe Lipitor during pregnancy or breastfeeding. This is because the drug may cause other side effects while pregnant and breastfeeding. For more information, see the “Warnings for Lipitor” section below.

* In this article, we use the terms “male,” “female,” “men,” and “women” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

Does my risk of side effects depend on what dose of Lipitor I take (10 mg, 20 mg, 40 mg, and 80 mg)?

It’s possible that the strength of Lipitor you take may change your risk of side effects. Lipitor is available in four strengths:

• 10 milligrams (mg)
• 20 mg
• 40 mg
• 80 mg

Taking a higher dose of Lipitor may increase the risk of side effects. So, if you’re taking a dose of 80 mg per day, your risk of side effects may be higher than that of someone taking a 10-mg dose.

If you’re having side effects from taking Lipitor, talk with your doctor. They can check whether your dose of Lipitor needs adjusting.

For more information about Lipitor’s dosages, see this article.

Are weight gain and hair loss side effects of Lipitor?

No, weight gain and hair loss are not side effects of Lipitor.

But there may be a link between taking statin medications such as Lipitor and an increase in appetite. An older study showed that people taking statins consumed more calories and fat than people not taking such drugs. So it is possible that this increase in appetite may lead to weight gain. But this was not reported in studies of the drug.

If you’re taking Lipitor to reduce your risk of heart problems due to type 2 diabetes, you may notice hair loss. This is because diabetes may increase the risk of hair loss in females and males.*

If you have weight gain or hair loss during your treatment with Lipitor, talk with your doctor or pharmacist. They may be able to recommend ways to manage your weight gain or hair loss.

* In this article, we use the term “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

Does Lipitor cause any eye-related side effects?

Although rare, it’s possible for Lipitor to cause blurry vision. This side effect was reported in studies of Lipitor.

In addition, eye-related side effects may be a symptom of another side effect that Lipitor causes. Lipitor can increase your risk of liver problems. One side effect of liver problems is yellowing of the eyes or skin.

If you have yellowing of the eyes or other eye-related changes while you’re taking Lipitor, contact your doctor. They can find out what may be causing your eye-related side effects and the best way to treat them.

Learn more about some of the side effects Lipitor may cause.

Muscle pain

You may develop muscle pain during treatment with Lipitor. Muscle pain was a common side effect reported in studies of the drug.

This side effect can be mild or severe. In some cases, muscle pain can also be a sign of a more serious side effect. Examples include rhabdomyolysis, a condition caused by the breakdown of muscle, and immune-mediating necrotizing myopathy, a rare muscle condition.

What might help

If you have muscle pain while taking Lipitor, talk with your doctor. They can determine what may be causing it.

If your muscle pain is mild, your doctor may recommend decreasing your Lipitor dose to see if the side effect lessens.

If you have severe muscle pain, contact your doctor as soon as possible. This may be a sign of a more serious condition. Your doctor might recommend that you stop taking Lipitor right away. And they’ll likely check you for rhabdomyolysis or immune-mediating necrotizing myopathy.

Liver damage

It’s possible to develop liver damage from taking statin medications such as Lipitor. Although liver damage was not a common side effect, it may still occur during Lipitor treatment.

Lipitor may cause increases in liver enzymes, which may indicate liver damage. Symptoms of liver damage include:

• yellowing of the eyes or skin
• belly pain
• nausea or vomiting

What might help

If you have any symptoms of liver damage during your treatment with Lipitor, tell your doctor right away. They can order blood tests to see how well your liver is working.

Your doctor will also check your liver function by ordering blood tests before you start taking Lipitor and throughout treatment.

If you develop increased liver enzymes or liver damage during treatment with Lipitor, your doctor may recommend decreasing your dose of Lipitor. Or they may pause your treatment until your liver enzyme levels increase to the point that it’s safe to resume treatment.

In more severe cases, your doctor may recommend that you take a different medication instead of Lipitor to treat your condition.

Joint pain

Lipitor can cause joint pain. This was one of the more common side effects reported in studies of Lipitor.

What might help

If you experience joint pain during your treatment with Lipitor, tell your doctor. They may be able to recommend ways to decrease this side effect. For example, they may suggest taking an over-the-counter pain medication, such as Tylenol (acetaminophen) or Advil (ibuprofen).

Diarrhea

It’s possible that you may have diarrhea during Lipitor treatment. Diarrhea was a common side effect reported in studies of the drug.

Symptoms of diarrhea include:

• belly pain or cramping
• bloating
• watery stools
• having frequent bowel movements

What might help

If you have diarrhea while taking Lipitor, tell your doctor. They can determine whether Lipitor is causing your diarrhea and the best ways to treat it.

If you have diarrhea, it is important to stay hydrated. Your doctor or pharmacist may also be able to recommend other ways to treat your diarrhea. For example, they may recommend taking an over-the-counter medication such as Imodium (loperamide).

Allergic reaction

Like most drugs, Lipitor can cause an allergic reaction in some people. But it’s not clear whether this side effect occurred in studies.

Symptoms can be mild to serious and can include:

• skin rash
• itchiness
• flushing (temporary warmth, redness, or deepening of skin color)
• swelling under your skin, usually in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What might help

If you have mild symptoms of an allergic reaction, such as a mild rash, call your doctor right away. They may suggest a treatment to manage your symptoms. Examples include:

• an antihistamine you take by mouth, such as Benadryl (diphenhydramine)
• a product you apply to your skin, such as hydrocortisone cream

If your doctor confirms you’ve had a mild allergic reaction to Lipitor, they’ll decide if you should continue using it.

If you have symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care.

If your doctor confirms you’ve had a serious allergic reaction to Lipitor, they may have you switch to a different treatment.

Keeping track of side effects

During your Lipitor treatment, consider taking notes on any side effects you’re having. You can then share this information with your doctor. This is especially helpful when you start taking new drugs or using a combination of treatments.

Your side effect notes can include things such as:

• what dose of the drug you were taking when you had the side effect
• how soon you had the side effect after starting that dose
• what your symptoms were
• how it affected your daily activities
• what other medications you were taking
• any other information you feel is important

Keeping notes and sharing them with your doctor will help them learn more about how Lipitor affects you. They can then use this information to adjust your treatment plan if needed.

Lipitor may not be right for you if you have certain medical conditions. These are known as drug-condition interactions. Other factors may also affect whether Lipitor is a good treatment option for you.

Talk with your doctor about your health history before starting Lipitor. The list below includes factors to consider.

Allergic reaction. If you’ve had an allergic reaction to Lipitor or any of its ingredients, your doctor will likely not prescribe Lipitor. Ask them what other medications are better options for you.

Diabetes. It’s possible that Lipitor may worsen diabetes. If you have diabetes, tell your doctor before starting treatment with Lipitor. Your doctor can determine if it’s safe for you to take the drug. Or they may recommend a different treatment option for you.

Thyroid problems. People with certain thyroid problems may have an increased risk of side effects, such as muscle pain, from taking Lipitor. Before you start taking Lipitor, tell your doctor about any thyroid problems that you have. Your doctor can help treat your thyroid condition before Lipitor treatment.

Kidney problems. Lipitor can cause muscle problems, which in rare cases may lead to kidney problems. If you already have kidney problems, taking this medication may worsen your condition. Your doctor can determine if it’s safe for you to take Lipitor with your kidney condition.

Stroke or mini-stroke in the last 6 months. Taking Lipitor after having a stroke or mini-stroke in the last 6 months may increase your risk of having another stroke. If you’ve had a recent stroke or mini-stroke, tell your doctor before starting treatment with Lipitor.

Liver problems. People with liver problems should not use Lipitor due to the risk of harm. Lipitor may cause liver problems to occur. If you already have a liver problem, taking this drug may worsen your condition. Due to this risk, your doctor will likely recommend a different treatment option for you.

Alcohol and Lipitor

There aren’t any known interactions between Lipitor and alcohol. But alcohol and Lipitor can both cause liver damage. So drinking alcohol while taking Lipitor may further increase the risk of liver problems.

If you drink alcohol, talk with your doctor about how much alcohol, if any, may be safe to drink during Lipitor treatment.

Pregnancy and breastfeeding while taking Lipitor

Lipitor may not be safe to take during pregnancy or while breastfeeding.

Currently, there is not enough information to determine if Lipitor affects a developing fetus, but it is possible. So, your doctor may not prescribe the drug during pregnancy.

It’s also unknown if Lipitor passes into breast milk or affects a child who is breastfed. Due to the possible risks, your doctor may advise you to avoid breastfeeding while taking Lipitor.

If you’re pregnant or breastfeeding or planning to become pregnant or breastfeed, tell your doctor before starting Lipitor treatment. They can help you understand the risks of taking Lipitor during these times. They may also recommend a different treatment option for you.

You may have side effects during your treatment with Lipitor. In most cases, its side effects are mild. But it’s possible to develop serious side effects from this medication.

Before you start treatment with Lipitor, talk with your doctor about side effects that could occur. Here are some questions to help get you started:

• Can Lipitor cause long-term side effects?
• Do I have an increased risk of Lipitor’s side effects due to my other medical conditions?
• How do the side effects of Lipitor compare with those of other drugs used to treat my condition?
• What should I do if I become pregnant during treatment with Lipitor?

To learn more about Lipitor, see these articles:

• All About Lipitor
• Dosage for Lipitor: What You Need to Know
• Lipitor Interactions: Alcohol, Medications, and Others
• Lipitor vs. Crestor: What You Should Know

To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

Statins and Weight Gain | Cardiology | JAMA Internal Medicine

Statins and Weight Gain | Cardiology | JAMA Internal Medicine | JAMA Network










[Skip to Navigation]

• Academic Medicine
• Acid Base, Electrolytes, Fluids
• Allergy and Clinical Immunology
• Anesthesiology
• Anticoagulation
• Art and Images in Psychiatry
• Assisted Reproduction
• Bleeding and Transfusion
• Cardiology
• Caring for the Critically Ill Patient
• Challenges in Clinical Electrocardiography
• Climate and Health
• Clinical Challenge
• Clinical Decision Support
• Clinical Implications of Basic Neuroscience
• Clinical Pharmacy and Pharmacology
• Complementary and Alternative Medicine
• Consensus Statements
• Coronavirus (COVID-19)
• Critical Care Medicine
• Cultural Competency
• Dental Medicine
• Dermatology
• Diabetes and Endocrinology
• Diagnostic Test Interpretation
• Drug Development
• Electronic Health Records
• Emergency Medicine
• End of Life
• Environmental Health
• Equity, Diversity, and Inclusion
• Ethics
• Facial Plastic Surgery
• Gastroenterology and Hepatology
• Genetics and Genomics
• Genomics and Precision Health
• Geriatrics
• Global Health
• Guide to Statistics and Methods
• Guidelines
• Hair Disorders
• Health Care Delivery Models
• Health Care Economics, Insurance, Payment
• Health Care Quality
• Health Care Reform
• Health Care Safety
• Health Care Workforce
• Health Disparities
• Health Inequities
• Health Informatics
• Health Policy
• Hematology
• History of Medicine
• Humanities
• Hypertension
• Images in Neurology
• Implementation Science
• Infectious Diseases
• Innovations in Health Care Delivery
• JAMA Infographic
• Law and Medicine
• Leading Change
• Less is More
• LGBTQIA Medicine
• Lifestyle Behaviors
• Medical Coding
• Medical Devices and Equipment
• Medical Education
• Medical Education and Training
• Medical Journals and Publishing
• Melanoma
• Mobile Health and Telemedicine
• Narrative Medicine
• Nephrology
• Neurology
• Neuroscience and Psychiatry
• Notable Notes
• Nursing
• Nutrition
• Nutrition, Obesity, Exercise
• Obesity
• Obstetrics and Gynecology
• Occupational Health
• Oncology
• Ophthalmology
• Orthopedics
• Otolaryngology
• Pain Medicine
• Pathology and Laboratory Medicine
• Patient Care
• Patient Information
• Pediatrics
• Performance Improvement
• Performance Measures
• Perioperative Care and Consultation
• Pharmacoeconomics
• Pharmacoepidemiology
• Pharmacogenetics
• Pharmacy and Clinical Pharmacology
• Physical Medicine and Rehabilitation
• Physical Therapy
• Physician Leadership
• Poetry
• Population Health
• Professional Well-being
• Professionalism
• Psychiatry and Behavioral Health
• Public Health
• Pulmonary Medicine
• Radiology
• Regulatory Agencies
• Research, Methods, Statistics
• Resuscitation
• Rheumatology
• Risk Management
• Scientific Discovery and the Future of Medicine
• Shared Decision Making and Communication
• Sleep Medicine
• Sports Medicine
• Stem Cell Transplantation
• Substance Use and Addiction Medicine
• Surgery
• Surgical Innovation
• Surgical Pearls
• Teachable Moment
• Technology and Finance
• The Art of JAMA
• The Arts and Medicine
• The Rational Clinical Examination
• Tobacco and e-Cigarettes
• Toxicology
• Translational Medicine
• Trauma and Injury
• Treatment Adherence
• Ultrasonography
• Urology
• Users’ Guide to the Medical Literature
• Vaccination
• Venous Thromboembolism
• Veterans Health
• Violence
• Women’s Health
• Workflow and Process
• Wound Care, Infection, Healing

Save Preferences

Privacy Policy | Terms of Use

This Issue

View Metrics

• 
  Download PDF




• 
  Share

  
  Twitter
  Facebook
  Email
  LinkedIn

• 
  Cite This
• 
  Permissions

Editor’s Note

July 2014

Rita F.  Redberg, MD, MSc

JAMA Intern Med. 2014;174(7):1046. doi:10.1001/jamainternmed.2014.1994

There remains much controversy over the risks and benefits of statins for primary prevention. Besides the risks of muscle aches, diabetes, and cognitive dysfunction, I have observed over the years that for many patients, statins provide a false reassurance, as people seem to believe that statins can compensate for poor dietary choices and a sedentary life. In an elegantly performed analysis of NHANES data from 1999 to 2010, Sugiyama and colleagues¹ have documented exactly such behavior. They found that compared with statin nonusers, statin users significantly increased their fat intake and calorie consumption, along with their BMI, in the last decade. This article raises concerns of a potential moral hazard of statin use, in addition to the already known adverse effects. Focusing on cholesterol levels can be distracting from the more beneficial focus on healthy lifestyle to reduce heart disease risk.

References

1.

Sugiyama
 T, Tsugawa
 Y, Tseng
 C-H, Kobayashi
 Y, Shapiro
 MF.  Different time trends of caloric and fat intake between statin users and nonusers among US adults: gluttony in the time of statins? [published online April 24, 2014].  JAMA Intern Med. doi:10.1001/jamainternmed.2014.1927.Google Scholar

Lipitor tablets 20 mg, 30 pcs 10 Dosage form

Coated tablets

Indications for use

Primary hypercholesterolemia (heterozygous familial and non-familial hypercholesterolemia, Frederickson type IIa), combined (mixed) hyperlipidemia (Frederickson type IIb and III), dysbetalipoproteinemia (Frederickson type III) (as an adjunct to diet), familial endogenous hypertriglyceridemia (Frederickson type IV), resistant to dietary treatment.

Homozygous hereditary hypercholesterolemia (as an adjunct to lipid-lowering therapy, including autohemotransfusion of LDL-purified blood).

Also indications for treatment are cardiovascular diseases against the background of dyslipidemia, secondary prevention in order to reduce the overall risk of death, myocardial infarction and re-hospitalization for angina pectoris.

Contraindications

Hypersensitivity to the components of the drug, active liver diseases (including active chronic hepatitis, chronic alcoholic hepatitis), increased activity of “liver” transaminases (more than 3 times) of unknown origin, liver failure (severity A and B on the Child-Pugh scale), pregnancy, lactation.

Caution. Severe electrolyte imbalance, endocrine and metabolic disorders, alcoholism, history of liver disease, arterial hypotension, severe acute infections, uncontrolled seizures, major surgery, trauma, childhood (efficacy and safety of use have not been established).

How to use: dosage and course of treatment

By mouth, taken at any time of the day, with or without food. The initial dose is 10 mg 1 time per day. The dose should be changed at intervals of at least 4 weeks. The maximum daily dose is 80 mg in 1 dose.

For primary hypercholesterolemia and combined (mixed) hyperlipidemia, 10 mg once a day is prescribed. The effect of treatment is manifested within 2 weeks, the maximum effect is observed within 4 weeks.

In homozygous familial hypercholesterolemia, 80 mg is prescribed once a day (lowering LDL by 18-45%).

Before starting therapy, the patient must be prescribed a standard hypocholesterolemic diet, which he must follow during treatment.

Pharmacological action

Lipid-lowering drug from the statin group. Selective competitive inhibitor of HMG-CoA reductase, an enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonic acid, which is a precursor of sterols, including cholesterol.

TG and cholesterol in the liver are included in the composition of VLDL, enter the plasma and are transported to peripheral tissues. LDL is formed from VLDL during interaction with LDL receptors.

The drug reduces plasma cholesterol and lipoprotein levels by inhibiting HMG-CoA reductase, cholesterol synthesis in the liver and increasing the number of “liver” LDL receptors on the cell surface, which leads to increased uptake and catabolism of LDL.

Reduces the formation of LDL, causes a pronounced and persistent increase in the activity of LDL receptors. Reduces LDL levels in patients with homozygous familial hypercholesterolemia, which usually does not respond to lipid-lowering drugs.

Reduces total cholesterol by 30-46%, LDL – by 41-61%, apolipoprotein B – by 34-50% and TG – by 14-33%; causes an increase in the level of HDL-cholesterol (high density lipoprotein) and apolipoprotein A.

Taking the drug Lipitor dose-dependently reduces the level of LDL in patients with homozygous hereditary hypercholesterolemia, resistant to therapy with other lipid-lowering drugs.

Treatment with Lipitor significantly reduces the risk of ischemic complications (including the development of death from myocardial infarction) by 16%, the risk of re-hospitalization for angina pectoris accompanied by signs of myocardial ischemia – by 26%.

Atorvastatin is not carcinogenic or mutagenic.

Side effects

From the side of the nervous system: more often than 2% – insomnia, dizziness; less often 2% – headache, asthenia, malaise, drowsiness, unusual dreams, amnesia, paresthesia, peripheral neuropathy, amnesia, emotional lability, ataxia, facial paralysis, hyperkinesis, depression, hyperesthesia, loss of consciousness.

From the senses: less than 2% – amblyopia, ringing in the ears, dryness of the conjunctiva, disturbance of accommodation, hemorrhage in the eyes, deafness, glaucoma, parosmia, loss of taste, taste perversion.

From the digestive system: more often 2% – nausea; less than 2% – heartburn, constipation or diarrhea, flatulence, gastralgia, abdominal pain, anorexia, decreased or increased appetite, dry mouth, belching, dysphagia, vomiting, stomatitis, esophagitis, glossitis, erosive and ulcerative lesions of the oral mucosa, gastroenteritis, hepatitis, biliary colic, cheilitis, duodenal ulcer, pancreatitis, cholestatic jaundice, liver dysfunction, rectal bleeding, melena, bleeding gums, tenesmus.

From the respiratory system: more often than 2% – bronchitis, rhinitis; less than 2% – pneumonia, dyspnea, bronchial asthma, epistaxis.

From the CCC: more often than 2% – chest pain; less than 2% – palpitations, vasodilation, migraine, postural hypotension, increased blood pressure, phlebitis, arrhythmia, angina pectoris.

From the side of the hematopoietic system: rarely 2% – anemia, lymphadenopathy, thrombocytopenia.

From the musculoskeletal system: more often 2% – arthritis; less than 2% – leg muscle cramps, bursitis, tendosynovitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, torticollis, muscle hypertonicity, joint contractures.

From the genitourinary system: more often 2% – urogenital infections, peripheral edema; less often 2% – dysuria (including pollakiuria, nocturia, urinary incontinence or urinary retention, imperative urge to urinate), nephritis, hematuria, vaginal bleeding, nephrourolithiasis, metrorrhagia, epididymitis, decreased libido, impotence, impaired ejaculation.

On the part of the skin: more than 2% – alopecia, xeroderma, increased sweating, eczema, seborrhea, ecchymosis, petechiae.

Allergic reactions to the components of the drug: less than 2% – pruritus, skin rash, contact dermatitis, rarely – urticaria, angioedema, facial edema, photosensitivity, anaphylaxis, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell’s syndrome).

Laboratory indicators: less than 2% – hyperglycemia, hypoglycemia, increased serum CPK, albuminuria.

Other: less than 2% – weight gain, gynecomastia, mastodynia, exacerbation of gout.

Overdose.

Treatment of overdose: there is no specific antidote, symptomatic therapy is carried out. Hemodialysis is ineffective.

Special instructions

Treatment may cause an increase in serum CPK, which should be taken into account in the differential diagnosis of retrosternal pain.

It is necessary to regularly monitor liver function indicators before starting treatment, 6 and 12 weeks after the start of the drug or after increasing the dose, and periodically during the entire period of use (until the condition of patients with transaminase levels exceeding normal is completely normalized). An increase in “liver” transaminases is observed mainly in the first 3 months of using the drug.

It is recommended to stop the drug or reduce the dose if the increase in AST and ALT values ​​is more than 3 times. The use of the drug should be temporarily discontinued with the development of clinical symptoms suggesting the presence of acute myopathy, or in the presence of factors predisposing to the development of acute renal failure against the background of rhabdomyolysis (severe infections, hypotension, traumatic surgery, trauma, metabolic, endocrine or severe electrolyte disturbances). Patients should be warned that they should immediately consult a doctor if unexplained pain or weakness in the muscles occurs, especially if they are accompanied by malaise or fever.

Women of reproductive age should use reliable methods of contraception.

Limited experience with 80 mg/day in children. Controlled studies in children have not been conducted, however, adverse reactions when using the drug in 8 children older than 9 years with familial homozygous hypercholesterolemia at a dose of up to 80 mg / day for 1 year were not detected.

Use in pregnancy and lactation

The drug is contraindicated in pregnancy and lactation.

Interactions

Co-administration of cyclosporine, fibrates, erythromycin, clarithromycin, immunosuppressive, antifungal drugs (related to azoles) and nicotinamide with atorvastatin increases plasma concentrations of atorvastatin (and the risk of myopathy).

Antacids reduce concentration by 35% (the effect on LDL cholesterol does not change).

Simultaneous use of atorvastatin with protease inhibitors, known as inhibitors of cytochrome CYP3A4, is accompanied by an increase in plasma concentrations of the drug.

When digoxin is used in combination with atorvastatin at a dose of 80 mg/day, the concentration of digoxin increases by approximately 20%.

Increases the concentration by 20% (when administered with the drug at a dose of 80 mg / day) of oral contraceptives containing norethindrone and ethinyl estradiol.

The lipid-lowering effect of the combination with colestipol is superior to that of either drug alone.

Storage conditions

Keep out of reach of children at temperatures up to 25°C.

Shelf life

2 years.

Terms of dispensing from pharmacies

By prescription.

Brand:

Phizer

Brand:

Turkey

Active ingredient ENG:

atorvastatin

Barcode:

8 699532095015

Video playback:

Weight gain preparations – indications and contraindications

To improve physical indicators bodybuilders, bodybuilders and athletes buy drugs for weight gain. One of the most popular varieties of such drugs are drugs that contain peptides. The class of medical devices in most cases is effective when an athlete needs a quick and high-quality weight gain.

Weight gain preparations with peptides

Peptides in weight gain preparations consist of protein fragments. Depending on the type of peptide preparation, the protein can be of both artificial and natural origin. Amino acid residues in the composition of medical products are linked by a peptide bond, which is why they are called so. Otherwise, weight gain drugs with peptides are called “information agents.” The active substance is responsible for the transfer of data between the smallest particles of the body.

Peptide weight gainers have the following effects on the body:

• gain muscle mass;
• balance of body functioning;
• stress reduction;
• Increase endurance and strength.

The advantage of weight gain products with peptides is that they are easily absorbed, and the risk of negative effects on the body during the course is minimized.

The best weight gain drugs with peptides

In sports pharmacology, there are 10 weight gain drugs with peptides that are in consistently high demand among athletes:

• Thymosin beta-4;
• Sermorelin;
• PEG-MGF;
• Melanotan 1;
• Melanotan 2;
• Ipamorelin;
• IGF1-LR3;
• GH FRAG 176-191;
• Hexarelin;
• GHRP-6 and GHRP-2;
• CJC-1295 DAC.