How does long-term Wellbutrin use affect the brain. Can Wellbutrin become habit-forming over time. What are drug-free alternatives to avoid long-term Wellbutrin effects. Discover evidence-based insights on Wellbutrin’s long-term impact and recovery options.

The Impact of Long-Term Wellbutrin Use on Brain Structure

Understanding the long-term effects of Wellbutrin (bupropion) on the brain is crucial for patients and healthcare providers alike. While extensive studies are limited, some research provides insights into potential changes in brain structure associated with prolonged use.

A case report involving a female patient who took bupropion for six weeks revealed intriguing results. The study noted increases in:

• Grey matter volume
• White matter volume
• Overall brain volume

These findings, though limited to a single case, suggest that Wellbutrin may influence brain structure even in a relatively short period. However, it’s important to note that more comprehensive studies are needed to draw definitive conclusions.

Comparative Studies on Brain Volume Changes

Research on other dopaminergic drugs provides additional context for understanding Wellbutrin’s potential effects. A study published in the German Journal of Psychopharmacology examined the impact of amphetamines on monkey brains. The results showed increased grey matter volume in specific brain areas, mirroring some of the changes observed in the human case study.

Human studies focusing on recovery from dopaminergic drug use, such as heroin and amphetamines, have also yielded interesting results. These studies demonstrated that both drug use and subsequent abstinence can alter brain volume. Specifically:

• Some brain areas showed increased volume during drug use
• Other areas experienced decreased volume
• Similar alterations were observed during periods of abstinence

While these studies didn’t directly examine Wellbutrin, they offer valuable insights into how dopaminergic drugs can influence brain structure. As Wellbutrin also affects dopamine levels, these findings may have implications for its long-term use.

The Habit-Forming Potential of Long-Term Wellbutrin Use

Is Wellbutrin habit-forming when used long-term? This question is crucial for patients considering or currently using the medication. To understand the potential for habit formation, it’s essential to examine the drug’s stimulant properties and the concept of drug tolerance.

Wellbutrin as a Stimulant

Wellbutrin belongs to the class of stimulant medications, which are known to have habit-forming tendencies. Like other stimulants, including caffeine, Wellbutrin can potentially lead to dependence over time.

Drug Tolerance and Its Role in Habit Formation

Drug tolerance is a key factor in the development of habits and addiction. As the body becomes accustomed to a substance, its effects may diminish, leading to:

1. The need for higher doses to achieve similar effects
2. A desire to avoid discontinuation syndrome

Over time, these factors can contribute to the development of dependence or addiction. At a cellular level, chronic drug use can lead to complex changes, known as plasticity, affecting various organs and tissues, including the brain.

Recreational Use and Abuse Potential

While most Wellbutrin users take the medication as prescribed, it’s important to note its potential for abuse. Studies have reported instances of Wellbutrin being crushed and snorted or used intravenously as a substitute for cocaine or crack. This has led to the nickname “poor man’s cocaine” in some circles.

The addictive potential of Wellbutrin has been documented in research published in the Journal of Addictions Nursing and the Journal of Addictive Medicine. Of particular concern is its widespread use in prison populations, where it’s relatively easy to obtain.

Health Risks Associated with Wellbutrin Abuse

Abusing Wellbutrin can lead to severe health consequences:

• Intravenous users risk developing abscesses at injection sites, potentially leading to deep tissue injuries and even spinal damage
• Those who snort crushed Wellbutrin are particularly vulnerable to seizures due to high doses
• A significant rise in emergency department visits has been observed among young people (ages 13-29) abusing the drug

Importantly, the risk of seizures doesn’t appear to be strongly correlated with the length or method of use, making Wellbutrin abuse particularly dangerous.

Safe Discontinuation of Long-Term Wellbutrin Use

For those who have been using Wellbutrin long-term, it’s crucial to approach discontinuation carefully. Abruptly stopping the medication can lead to severe withdrawal symptoms. Instead, patients should seek medical assistance for a gradual, well-supervised reduction in dosage.

The Importance of Medical Supervision

Why is medical supervision crucial when discontinuing Wellbutrin? A healthcare provider can:

• Create a personalized tapering plan
• Monitor for potential withdrawal symptoms
• Adjust the plan as needed to ensure patient comfort and safety
• Provide support and resources throughout the process

This approach minimizes the risk of severe discontinuation symptoms and increases the likelihood of a successful transition off the medication.

Drug-Free Alternatives to Long-Term Wellbutrin Use

Is it possible to address depression without relying on long-term medication use? While Wellbutrin and other antidepressants play a crucial role in mental health treatment, there are indeed drug-free alternatives worth considering.

The Role of Nutrition in Mental Health

Nutritional neuroscience has emerged as a promising field, demonstrating the profound impact of diet on mental health. Research has shown that nutrition can influence:

• Emotions
• Behavior
• Cognitive function

By optimizing nutrition, it may be possible to address the root causes of depression and other mental health conditions, potentially reducing or eliminating the need for long-term medication use.

Holistic Approaches to Mental Health

Beyond nutrition, a range of holistic therapies can complement or, in some cases, replace traditional medication-based treatments. These may include:

• Psychotherapy and counseling
• Mindfulness and meditation practices
• Regular exercise and physical activity
• Sleep optimization
• Stress reduction techniques

These approaches focus on addressing the underlying factors contributing to depression, rather than simply managing symptoms.

The Alternative to Meds Center Approach

The Alternative to Meds Center offers a comprehensive program for those seeking to recover from long-term Wellbutrin use or explore alternatives to medication. Their approach includes:

• Personalized treatment plans
• Nutritional therapy and supplementation
• Detoxification protocols
• Holistic therapies such as yoga and meditation
• Counseling and psychological support

By addressing both the physical and psychological aspects of mental health, this approach aims to provide lasting relief without relying solely on medication.

Understanding the Risks and Benefits of Long-Term Wellbutrin Use

While Wellbutrin can be an effective treatment for depression, it’s essential to weigh the potential long-term risks against the benefits. What factors should patients and healthcare providers consider when evaluating long-term Wellbutrin use?

Potential Benefits of Long-Term Use

• Sustained relief from depressive symptoms
• Improved quality of life and daily functioning
• Reduced risk of depressive episode recurrence

Potential Risks and Side Effects

• Changes in brain structure and function
• Development of drug tolerance and potential dependence
• Increased risk of seizures, particularly at higher doses
• Potential for abuse and misuse

It’s crucial for patients to have open, ongoing discussions with their healthcare providers about the long-term implications of Wellbutrin use. Regular check-ins and assessments can help ensure that the benefits continue to outweigh the risks over time.

The Future of Depression Treatment: Integrating Medication and Holistic Approaches

As our understanding of depression and its treatment evolves, what does the future hold for patients and healthcare providers? The trend appears to be moving towards a more integrated approach, combining the best of traditional medication-based treatments with evidence-based holistic therapies.

Personalized Treatment Plans

The future of depression treatment is likely to focus on highly personalized approaches. This may include:

• Genetic testing to determine the most effective medications
• Individualized nutritional plans based on metabolic profiles
• Tailored combination therapies incorporating medication and holistic approaches

Advances in Nutritional Psychiatry

As research in nutritional neuroscience progresses, we can expect to see more targeted dietary interventions for mental health. This may involve:

• Specific nutrient supplementation protocols
• Gut microbiome optimization for mental health
• Dietary plans designed to support brain health and neurotransmitter function

Technology-Assisted Treatments

Emerging technologies are likely to play an increasing role in depression treatment. This could include:

• AI-powered mood tracking and early intervention systems
• Virtual reality therapy for cognitive behavioral interventions
• Wearable devices for real-time monitoring of physiological markers associated with depression

By combining these advanced approaches with traditional medication-based treatments, healthcare providers may be able to offer more effective, sustainable solutions for depression management.

Empowering Patients: Making Informed Decisions About Long-Term Wellbutrin Use

Given the potential long-term effects of Wellbutrin use, how can patients take an active role in their treatment decisions? Empowering patients with knowledge and resources is crucial for optimal mental health outcomes.

Education and Self-Advocacy

Patients can take several steps to become more informed and engaged in their treatment:

• Research reputable sources on Wellbutrin and its effects
• Keep a detailed log of symptoms, side effects, and overall well-being
• Prepare questions for healthcare providers before appointments
• Seek second opinions when considering long-term medication use

Exploring Complementary Therapies

While continuing prescribed medication, patients may benefit from exploring complementary approaches:

• Cognitive-behavioral therapy or other forms of psychotherapy
• Mindfulness and stress reduction techniques
• Nutritional counseling and dietary modifications
• Regular exercise and physical activity

By incorporating these strategies, patients may be able to enhance the effectiveness of their medication while potentially reducing the need for long-term use.

Building a Support Network

A strong support network can play a crucial role in managing depression and making informed treatment decisions. This may include:

• Joining support groups for individuals using antidepressants
• Engaging with mental health advocacy organizations
• Involving trusted friends and family members in treatment discussions

By taking an active role in their treatment and leveraging available resources, patients can work towards optimal mental health outcomes while minimizing the potential risks associated with long-term Wellbutrin use.

Recover from long-term effects of Wellbutrin

Alternative to Meds News & Blog Articles

Does Taking Wellbutrin Long-term Change the Brain?

We could find no published long-term or extensive studies on the effects of Wellbutrin on the human brain. A case report of one female given bupropion for 6 weeks showed an increased volume of grey matter, white matter, and overall brain volume compared to pre-treatment. In a study published in the German Journal of Psychopharmacology, monkeys were given amphetamines over a period of time, and then their brains were scanned. Their brain images showed similar increases in grey matter volume in one specified area of the brain. Other studies on humans who were recovering from dopaminergic drug use showed that brain volume is altered both during drug use and after a period of abstinence. Dopaminergic drugs such as heroin and amphetamines, but not Wellbutrin, were studied. The results were inconclusive beyond demonstrating that drug use was associated with increased volume in some areas of the brain, and decreased volume in other areas of brain tissue, and that drug abstinence was also associated with similar alterations of brain volume. As Wellbutrin is also a dopaminergic drug, these results are of some interest here, but researchers will have to test further to determine any information that would be helpful to drug regulators, prescribers, and consumers.^7-9

Does Wellbutrin Taken Long-term Become Habit-forming?

In drug terminology, habit-forming means having addictive characteristics. Stimulants, including coffee, all have a tendency to become habit-forming.  Drug tolerance is a factor in the architecture of addiction. Drug tolerance means reduced or diminished effect, therefore as a result of prolonged exposure, one is led to take a higher dose to get similar effects, and to avoid discontinuation syndrome.  At the cellular and biological level, a complex set of changes occurs, referred to as plasticity, that results from the chronic effects of daily ingestion of the substance on the internal organs and tissues, including the brain. Over time, these changes become chronic, and addiction or dependence develops. ¹⁵ 

Studies have reported on crushing and snorting bupropion, and intravenous use for recreational users as a substitute drug for cocaine or crack. Wellbutrin has been nicknamed “poor man’s cocaine” in news stories, and its addictive potential has been reported in research published in the Journal of Addictions Nursing and the Journal of Addictive Medicine.^10,11 Bupropion has become extensively used in the prison population as it is legal and easy to procure. Users who inject are particularly vulnerable to abscesses that form at the injection site due to the caustic nature of the drug which can cause deep tissue injuries that extend right down to the bone and also can cause spinal injury. Users who snort the crushed powder have been shown particularly vulnerable to seizures, due to the high doses that are involved. Bupropion has seen a significant rise in the number of people between the ages of 13 and 29 who abuse the drug and may end up at the emergency department suffering from seizures, hallucinations, tremors, tachycardia, agitation, and many other unmanageable reactions, including death. It is worth noting that the length or chronicity or method of use did not significantly determine the frequency of patients presenting with seizures. ^12,13,16

However, most users of Wellbutrin are not recreational users but are taking it as prescribed. Nonetheless, any dopaminergic or stimulant drug can become habit-forming, especially after it has been used for a long time and tolerance or dependence has developed.  Never abruptly stop taking Wellbutrin, but seek medical assistance for a well-supervised, gradual reduction to avoid severe discontinuation symptoms.¹

Are There Drug-free Options to Avoid Long-term effects of Wellbutrin?

In the best of all worlds, holistic remedies for depression would be considered first-line treatments. But we live in an imperfect world, and many become tangled up in prescription drug treatments that have the potential to worsen rather than improve conditions.

In contrast, nutrition is a highly effective, though largely overlooked, therapy for preventing and reversing mental health sub-optimum conditions. Nutritional neuroscience has demonstrated how factors such as emotions, behavior, and cognition are reliant on nutrition.²³

Whether one has not yet begun drug treatment or is in a recovery phase that likely includes cessation, holistic therapies exist that can help eliminate the original symptoms that led to a prescribed drug regimen.

Alternative to Meds Center uses an extensive palette of drug-free treatments for recovery after Wellbutrin or other drugs failed to achieve the desired results. You can view these in great detail on our services overview pages.

Because of complications that can arise from abrupt dopaminergic drug cessation, medical oversight and a gradual discontinuation approach are strongly advised.

Is Wellbutrin Safe for Pregnancy?

Safety studies have shown that bupropion is excreted into breast milk. Wellbutrin is classed as a C drug for pregnancy, which indicates the drug should be avoided unless there is strong medical justification to take the drug. ²

A long-term study conducted on 136 pregnant women discovered that there were significantly more spontaneous abortions (miscarriages) in the women who were taking bupropion in the first trimester — 20 in total, from a group of 136 women.¹⁷ 

These are safety concerns that should be discussed with caregivers so that healthy decisions can be made well before any negative consequences may arise for the mother or child.

Recovery from Long-term Effects of Wellbutrin at Alternative to Meds Center

Orthomolecular medicine provides a foundation for a successful transition to becoming drug-free and achieving improvements in mental well-being. There are many aspects to recovery that include testing for nutritional deficiencies, neurotoxin removal, correction of diet, as well as an enormous number of therapies that can bring about positive changes that can be sustained for the rest of one’s life without relying on prescription drugs for relief.

Please contact us for more information on our holistic, medically supervised recovery programs and any other information that may be useful such as insurance coverage, length of programs, and other questions you may have. Alternative to Meds Center has been focused for nearly 2 decades on helping people recover from diverse conditions including successful recovery from the long-term effects of Wellbutrin and other mental health concerns.

Side effects and how to manage them

Wellbutrin (bupropion hydrochloride) is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it for the following uses in adults:

• treat major depressive disorder (also called depression)
• prevent seasonal affective disorder*

Wellbutrin is meant to be used as a long-term treatment.

Here are some fast facts about Wellbutrin:

• Active ingredient: bupropion hydrochloride
• Drug class: antidepressants
• Drug form: sustained-release (SR) tablets, extended-release (XL) tablets
• FDA approval year: 1985

As with other drugs, Wellbutrin can cause side effects. Read on to learn about potential common, mild, and serious side effects. For a general overview of Wellbutrin, including details about its uses, see this article.

* Wellbutrin XL is approved to treat depression and help prevent seasonal affective disorder. Wellbutrin SR is only approved to treat depression.

Wellbutrin can cause certain side effects, some of which are more common than others. These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

These are just a few of the more common side effects reported in clinical trials by people who took Wellbutrin SR and Wellbutrin XL:

• dry mouth
• anxiety
• constipation
• nausea
• sleep problems, such as insomnia
• headache*

* For more information about this side effect, see “Side effect specifics” below.

Mild side effects can occur with Wellbutrin use. This list doesn’t include all possible mild side effects of the drug. For more information, you can refer to the prescribing information for Wellbutrin SR and Wellbutrin XL.

Mild side effects that have been reported with Wellbutrin include:

• anxiety
• constipation
• nausea
• sweating
• skin rash
• sleep problems, such as insomnia
• loss of appetite
• abdominal pain
• tremor
• agitation (restlessness)
• heart palpitations
• ringing in the ears
• muscle aches
• memory loss
• sore throat
• dry mouth
• dizziness
• hot flashes
• increased or decreased libido
• headache*
• changes in body weight, such as weight loss* and weight gain*
• mild allergic reaction*

These side effects may be temporary, lasting a few days to weeks. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you develop a side effect while taking Wellbutrin and want to tell the FDA about it, visit MedWatch.

* For more information about this side effect, see “Side effect specifics” below.

Wellbutrin may cause serious side effects. Serious side effects are rare and are less likely to occur if Wellbutrin is taken exactly as prescribed. The list below may not include all possible serious side effects of the drug. For more information, you can refer to the prescribing information for Wellbutrin SR and Wellbutrin XL.

If you develop serious side effects while taking Wellbutrin, call your doctor right away. If the side effects seem life threatening or you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Serious side effects that have been reported and their symptoms include:

• Closed-angle glaucoma. Symptoms can include:
  • dilated pupils
  • blurry vision
  • loss of vision
  • eye pain
  • halos around lights
• Mania and hypomania episodes. Symptoms can include:
  • changes in mood
  • feeling more irritated
  • talking faster than normal
  • aggressive behavior
  • intense increases or decreases in energy levels
• Mental health changes. Symptoms can include:
  • delusions (untrue beliefs or thoughts)
  • hallucinations
  • changes in concentration
  • paranoia
  • confusion
• High blood pressure.*
• Seizures.*
• Risk of suicidal thoughts and behaviors.*†
• Severe allergic reaction.*

* For more information about this side effect, see “Side effect specifics” below.
† Wellbutrin SR and Wellbutrin XL have a boxed warning for this side effect. This is a serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effect specifics” section below.

Wellbutrin may cause several side effects. Here are some frequently asked questions about the drug’s side effects and their answers.

How does Wellbutrin XL’s side effects compare with those of Wellbutrin SR?

Wellbutrin XL and Wellbutrin SR have similar side effects. This is because they have the same active ingredient, bupropion hydrochloride. Common side effects of both drugs include dry mouth, abdominal pain, insomnia, and nausea.

The main difference between these drug forms is that Wellbutrin XL is released slower in your body. There shouldn’t be any major difference in the type of side effects between the two forms when used to treat depression. However, since only Wellbutrin XL is approved to treat seasonal affective disorder (SAD), different side effects may occur in people with SAD compared to depression.

If you have questions about the side effects from Wellbutrin XL and Wellbutrin SR, talk with your doctor or pharmacist.

Does Wellbutrin cause sexual side effects?

It’s possible that Wellbutrin may cause sexual side effects.

In clinical trials of Wellbutrin XL and Wellbutrin SR, increased and decreased libido were reported during treatment. Libido is the feeling of sexual drive or sexual desire. Sexual side effects caused by Wellbutrin were rare in these trials.

Many antidepressants, such as Zoloft (sertraline) and Effexor XR (venlafaxine), can cause sexual side effects. Wellbutrin is typically regarded as one of the antidepressants that are least likely to cause sexual side effects.

If you have questions about sexual side effects and Wellbutrin, talk with your doctor or pharmacist.

If my dose of Wellbutrin is increased from 150 mg to 300 mg, will I experience certain side effects?

It’s possible that you may experience more side effects if your dose of Wellbutrin is increased.

They typical maintenance dose for treating depression and SAD is 300 milligrams (mg) per day. With most medications, there’s a risk of more frequent side effects as you increase the dose. So, if you were experiencing side effects when taking the 150 mg dose of Wellbutrin, it’s possible that you’ll experience more frequent side effects when your dose is increased to 300 mg. These side effects can include nausea, dizziness, and abdominal pain.

Talk with your doctor if you experience side effects with the 150 mg dose of Wellbutrin. Since side effects are similar between 150 mg and 300 mg, a larger dose may increase severity or frequency of side effects. However, side effects at the 150 mg dose may indicate that you might not be able to tolerate Wellbutrin long-term.

If you have questions about side effects with your dose of Wellbutrin, talk with your doctor of pharmacist.

To learn more about Wellbutrin’s dosage, see this article.

Can Wellbutrin cause long-term side effects?

Yes, it’s possible for Wellbutrin to cause long-term side effects, such as weight changes, seizures, and episodes of mania and hypomania.

However, most side effects that people taking this medication experiences were short-term. Or they went away after stopping Wellbutrin treatment.

Talk with your doctor if you have questions about long-term side effects with Wellbutrin. They can discuss the risk of side effects with you.

Will stopping Wellbutrin cause withdrawal symptoms?

Withdrawal symptoms after stopping treatment with Wellbutrin were not reported in clinical trials of Wellbutrin XL and Wellbutrin SR. Withdrawal symptoms refer to unpleasant side effects that occur when you stop taking a drug that your body is used to.

Although Wellbutrin was not reported to cause withdrawal symptoms in clinical trials, it’s recommended that the dosage for Wellbutrin XL should be tapered (lowered) before stopping the medication. You should never stop a medication without discussing with your doctor first.

If you’re thinking of stopping Wellbutrin, talk with your doctor. They can determine the safest way for your to stop treatment with Wellbutrin.

Is hair loss a side effect of Wellbutrin?

No, hair loss was not reported in clinical trials of Wellbutrin XL and Wellbutrin SR.

There are many factors that can contribute to hair loss, such as other medications, genetics, and hormone changes in your body.

Talk with your doctor if you experience hair loss while taking Wellbutrin. Your doctor will assess your symptoms and help you figure out what the possible cause could be.

Learn more about some of the side effects that Wellbutrin may cause. To find out how often side effects occurred in clinical trials, see the prescribing information for Wellbutrin SR and Wellbutrin XL.

Risk of suicidal thoughts and behaviors

Wellbutrin has a boxed warning for the risk of suicidal thoughts and behaviors. This is a serious warning from the Food and Drug Administration (FDA). Many antidepressants, including Wellbutrin, have a warning for the risk of suicidal thoughts and behaviors and the highest risk are typically in people ages 18 to 24 years old.

In clinical trials of Wellbutrin XL and Wellbutrin SR, suicidal thoughts and behaviors were not reported. However, the clinical trials for Zyban (bupropion) in smoking cessation showed that there were some people who experienced suicidal thoughts and behaviors. The active ingredient in Wellbutrin and Zyban is bupropion, so it’s possible that side effects may be similar.

Symptoms of suicidal thoughts and behaviors may include:

• frequently thinking about suicide
• having a plan for committing suicide
• thinking about what life would be like for others if you were not around
• changes in mood that are different than usual
• anger
• irritability

It’s important to note that the risk of suicidal thoughts and behavior is also a symptom of depression and seasonal affective disorder (SAD). If you experience suicidal thoughts and behaviors, it may be difficult to tell if your symptoms are being caused by Wellbutrin, depression, or SAD.

What you can do

Your doctor will assess your risk for suicidal thoughts and behaviors before you start taking Wellbutrin. They may also educate family members or caretakers on how to monitor and recognize signs and symptoms of suicidal thoughts and behaviors to help act as a support system for you.

Starting Wellbutrin on the lowest starting dose possible for treatment may help reduce your risk of suicidal thoughts and behaviors. Talk with your doctor right away if you feel like you have any signs or symptoms of suicidal thoughts or behaviors.

Weight gain or weight loss

In clinical trials of Wellbutrin XL and Wellbutrin SR, weight gain and weight loss were reported. Weight changes were common in clinical trials of Wellbutrin for treating depression, with weight loss being more common than weight gain.

Clinical trials showed that people were more likely to lose weight while taking Wellbutrin for depression or SAD.

What you can do

Talk with your doctor if you experience any changes in weight while taking Wellbutrin. Your doctor will assess the severity of your symptoms and recommend the best treatment option for you.

Headache

Headache was a common side effect reported in clinical trials of Wellbutrin XL and Wellbutrin SR. Headaches were mild to moderate in severity and most people did not have to stop taking Wellbutrin. Symptoms of headache include pain on both sides of your head, pain on the front and back of your head, and a dull pain intensity.

What you can do

Talk with your doctor if you start to experience headaches that are bothersome or interfere with your daily activities. Your doctor may recommend pain medications such as acetaminophen (Tylenol) or ibuprofen (Motrin) to help with your symptoms.

Seizure

In clinical trials of Wellbutrin SR, seizures were rare. Seizures were not studied in clinical trials of Wellbutrin XL. However, post marketing studies after Wellbutrin XL was approved reported that the side effect was also rare.

Symptoms of seizures can include:

• fainting
• uncontrollable movements in your arms and legs
• confusion
• stiffening of your arms and legs
• dizziness

There are other factors that can further increase your risk for seizures from Wellbutrin, such as using illicit drugs, severe head injuries, and severe liver damage.

What you can do

Your doctor will typically start you on the lowest effective dose of Wellbutrin for treating depression and SAD. If you need to increase your dose, it will be done slowly and over a longer period of time. This may help reduce the risk of seizures from Wellbutrin.

Clinical trials of Wellbutrin XL recommend a maximum dose of 450 milligrams (mg). And clinical trials for Wellbutrin SR recommend a maximum daily dose of 400 mg.

Call 911 or your local emergency number if you think you’re experiencing a seizure. Your doctor will likely stop treatment with Wellbutrin if you experience a seizure.

High Blood Pressure

High blood pressure may occur while you’re taking Wellbutrin. This side effect was common in clinical trials of Wellbutrin XL and Wellbutrin SR. Clinical trials showed that high blood pressure was serious enough in some people to where they had to stop taking Wellbutrin.

Symptoms of high blood pressure may include:

• headaches
• increased heart rate
• confusion
• chest pain

What you can do

Before you start treatment with Wellbutrin, your doctor will check your blood pressure. They’ll likely monitor your blood pressure throughout treatment with the drug. You should also regularly check your blood pressure to increase the likelihood of catching any blood pressure changes before they become severe.

If you have any symptoms of high blood pressure during Wellbutrin treatment, tell your doctor right away. They may stop treatment with Wellbutrin.

Allergic reaction

As with most drugs, Wellbutrin can cause an allergic reaction in some people. It’s unknown if allergic reactions occurred in clinical trials of Wellbutrin XL and Wellbutrin SR.

Symptoms can be mild or serious and can include:

• skin rash
• itching
• flushing
• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your mouth, tongue, or throat, which can make it hard to breathe

What you can do

For mild symptoms of an allergic reaction, call your doctor right away. They may recommend ways to ease your symptoms and determine whether you should keep taking Wellbutrin. However, if your symptoms are serious and you think you’re having a medical emergency, immediately call 911 or your local emergency number.

Suicide prevention

If you know someone at immediate risk of self-harm, suicide, or hurting another person:

• Ask the tough question: “Are you considering suicide?”
• Listen to the person without judgment.
• Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.
• Stay with the person until professional help arrives.
• Try to remove any weapons, medications, or other potentially harmful objects.

If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988.

Click here for more links and local resources.

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Boxed warning: Risk of suicidal thoughts and behaviors

This drug has a boxed warning for the risk of suicidal thoughts and behaviors. This is a serious warning from the Food and Drug Administration (FDA). For details, see the “Side effect specifics” section above.

Other precautions

Be sure to talk with your doctor about your health history before you take Wellbutrin. This drug may not be the right treatment for you if you have certain medical conditions or other factors that affect your health. These are considered drug-condition or drug-factor interactions. The conditions and factors to consider include:

Seizure disorder. Wellbutrin is contraindicated in people who have a history of seizure disorder. A contraindication is a factor or condition that could prevent your doctor from prescribing a drug due to risk of harm. Make sure to let your doctor know if you have a history of seizures as they may recommend a different medication for you.

Allergic reaction. If you’ve had an allergic reaction to Wellbutrin or any of its ingredients, your doctor will likely not prescribe Wellbutrin. Ask your doctor what other medications may be better options for you.

Bulimia or anorexia. Talk with your doctor if you have or have had a history of bulimia or anorexia. These conditions may increase your risk of seizures from Wellbutrin. Ask your doctor what other medications may be safer for you.

Monoamine Oxidase Inhibitor (MAOI). If you’re taking an MAOI, such as Eldepryl (selegiline), your doctor will likely not prescribe Wellbutrin. They stop MAOI treatment for at least 14 days before starting Wellbutrin. Taking Wellbutrin in combination with an MAOI can significantly increase your risk of having life-threatening high blood pressure. Be sure to tell your doctor about every medication you’re taking before starting treatment with Wellbutrin.

Closed-angle glaucoma. If you have a history of untreated narrow eye angles you may have a higher risk of closed-angle glaucoma if you take Wellbutrin. Closed-angle glaucoma is a medical emergency that can cause vision loss if not treated right away. Talk with your doctor about your eye history before starting Wellbutrin. Your doctor may recommend an eye exam before starting treatment.

Alcohol with Wellbutrin

It’s recommended to avoid drinking alcohol while taking Wellbutrin. This drug is known to interact with alcohol.

Post marketing and clinical trials of Wellbutrin XL and Wellbutrin SR show that taking Wellbutrin and alcohol together may increase your risk of serious mental health side effects. These side effect can include hallucinations, paranoia, anxiety, and mood changes.

If you’d like to drink alcohol while taking Wellbutrin, talk with your doctor. They can help determine whether it’s safe for you and discuss the risks associated with alcohol use while taking Wellbutrin.

Also, be sure to tell your doctor if you have suddenly stopped drinking alcohol during your treatment with Wellbutrin. Doing so may increase your risk of seizures as a side effect. (For more information, refer to the “Side effect specifics” section above. )

Pregnancy and breastfeeding while taking Wellbutrin

It’s not known whether Wellbutrin is safe to take during pregnancy.

Animal studies have shown problems with fetal development in offspring born to animals that were given Wellbutrin during pregnancy. However, animal studies don’t always predict what will happen in humans.

Untreated depression or seasonal affective disorder also present risks to the fetus or unborn baby during pregnancy. Talk with your doctor if you’re pregnant or are planning to become pregnant. Your doctor will weigh the risks and benefits of taking Wellbutrin and determine the best treatment plan for you.

If you and your doctor decide to continue Wellbutrin treatment during pregnancy, there’s a registry that monitors your treatment. You may sign up for the registry by calling the National Pregnancy Registry for Antidepressants at 844-405-6185 or visit the registry website.

Wellbutrin is known to pass into breast milk. However, it’s not known if the drug may cause side effects in a breastfed child.

Talk with your doctor if you’re breastfeeding or are planning to breastfeed. They can help advise you on the risks and benefits of breastfeeding while taking Wellbutrin. They can also recommend healthy ways to feed your child.

Wellbutrin XL is FDA approved to treat depression and seasonal affective disorder. And Wellbutrin SR is FDA approved to treated depression. If you’re prescribed Wellbutrin by your doctor, there’s a chance you may experience side effects. These side effects are mostly mild to moderate in severity, however serious side effects can occur. If you’d like to learn more about Wellbutrin, talk with your doctor or pharmacist. They can help answer any questions you have about side effects from taking the drug.

Besides talking with your doctor, you can do some research on your own. These articles might help:

• More information about Wellbutrin. For details about other aspects of Wellbutrin, refer to this article.
• Dosage. For information about the dosage of Wellbutrin, view this article.
• Interactions. To find out about Wellbutrin’s interactions, see this article.
• A look at your condition. For details about the conditions Wellbutrin’s used to treat, see our depression and mental health hubs.

Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

EMA recommended for approval drug for weight loss

The European Medicines Agency (EMA) granted marketing approval for Mysimba (naltrexone + bupropion) for weight loss in overweight or obese adults. This remedy is recommended for use in combination with a low-calorie diet and physical activity.

Mysimba is a combination of two active ingredients – bupropion and naltrexone, which were previously approved for use in EU countries for other diseases: Wellbutrin (bupropion) – for depression, Zyban (bupropion) – for the treatment of nicotine addiction, Nalorex (naltrexone) – for the treatment drug addiction. The active ingredients in Mysimba affect two areas of the brain responsible for controlling food intake and energy expenditure, as well as the food reward system.

The drug is a prescription drug and is recommended for use in adults with a body mass index of 30 kg/m ² and above (obesity) or 27-30 kg/m ² (overweight), with one or more complications associated with overweight, such as type II diabetes, high blood cholesterol or blood pressure.

The efficacy of Mysimba was evaluated in 4 clinical studies that included obese and overweight patients with or without complications associated with overweight. All patients participating in the studies had to change their lifestyle: follow a low-calorie diet and exercise regularly. The results showed a clinically significant loss of body weight in participants taking Mysimba compared to participants in the control group who used placebo.

The study of the safety profile of the drug showed the possible occurrence of adverse reactions associated with disorders of the central nervous system and the gastrointestinal tract, as well as the possible development of cardiovascular outcomes in the long term. Interim results of a study conducted to determine the risks from the cardiovascular system, when taking the drug, did not show the development of serious side effects. In the future, a second study is planned in order to continue monitoring serious cardiovascular outcomes associated with Mysimba in the long term.

The EMA Committee for Medicinal Products for Human Use (CHMP) recommends evaluating drug efficacy 16 weeks after initiation of therapy. If during this period the patient does not experience at least a 5% decrease in initial body weight, treatment with Mysimba should be discontinued.

Being overweight or obese is a major risk factor for a range of chronic diseases, including type II diabetes and cardiovascular disease. Currently, pharmacological treatments for obesity are rather limited.

Based on www.ema.europa.eu

Wellbutrin and Zoloft prescription depression treatment: differences and side effects

• Are Wellbutrin and Zoloft the same thing?
• What are the possible side effects of Wellbutrin?
• What are the possible side effects of Zoloft?
• What is Wellbutrin?
• What is Zoloft?
• What drugs interact with wellbutrin?
• What medicines interact with Zoloft?
• How should I take Wellbutrin?
• How should I take Zoloft?

Are Wellbutrin and Zoloft the same thing?

Wellbutrin (bupropion) and Zoloft (sertraline) are antidepressants used to treat major depression. Wellbutrin is also used to treat seasonal affective disorder.

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Zoloft is also used to treat obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).

The brand name Zyban bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects.

Wellbutrin and Zoloft are different types of antidepressants. Wellbutrin is an aminoketone and Zoloft is a selective serotonin reuptake inhibitor (SSRI).

What are the possible side effects of Wellbutrin?

Common side effects of Wellbutrin include:

• anxiety
• dry mouth,
• insomnia,
• headache,
• nausea,
• vomiting,
• constipation,
• abdominal pain,
• dizziness,

9002 5 ringing in the ears,

• vision problems or blurred vision,
• loss of interest to sex,
• sore throat,
• muscle pain,
• itching or skin rash,
• increased sweating,
• frequent urination,
• tremor,
• appetite changes,
• weight loss or gain,
• joint pain,
• strange taste in the mouth,
• diarrhea and
• convulsions (especially at higher doses).

What are the possible side effects of Zoloft?

Common side effects of Zoloft include:

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• drowsiness
• drowsiness
• tired feeling
• nervousness
• trouble sleeping (insomnia)
• dizziness
• nausea
• skin rash
• headache
• diarrhea
• constipation

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• abdominal pain
• dry mouth
• changes in appetite
• abnormal ejaculation
• impotence
• decreased libido
• difficulty with orgasm
• dry mouth and
• weight loss.

Tell your doctor if you have any serious side effects of Zoloft, including:

• very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeat, feeling like you might pass out;
• agitation, hallucinations, fever, hyperactive reflexes, tremor;
• nausea, vomiting, loss of appetite, unsteadiness, loss of coordination;
• trouble concentrating, memory problems, weakness, fainting, convulsions, shallow breathing or breathing that stops.

What is Wellbutrin?

Wellbutrin is a prescription medicine used to treat adults with a specific type of depression called major depressive disorder.

Talk to your doctor if you do not think your condition is improving after treatment with Wellbutrin.

What is Zoloft?

Zoloft (sertraline) is an SSRI (Selective Serotonin Reuptake Inhibitor) antidepressant drug indicated for the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder. (PMDR).

What drugs interact with wellbutrin?

Do not take Wellbutrin if you:

• have or have had a seizure disorder or epilepsy.
• are taking Zyban (used to help people stop smoking) or any other medicines that contain bupropion hydrochloride, such as Wellbutrin SR Extended Release Tablets or Wellbutrin XL Extended Release Tablets. Bupropion is the same ingredient found in Wellbutrin.
• drink a lot of alcohol and stop drinking abruptly, or use drugs called sedatives (they make you sleepy) or benzodiazepines and you suddenly stop using them.
• have taken a depression medicine called a monoamine oxidase inhibitor (MAOI) such as Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate) or Marplan (isocarboxazid) for depression in the last 14 days.
• have or have had an eating disorder such as anorexia nervosa or bulimia.
• you are allergic to the active ingredient Wellbutrin, bupropion, or any of the inactive ingredients. You will find a complete list of Wellbutrin ingredients at the end of this leaflet.

What medicines interact with Zoloft?

Zoloft may interact with cold or allergy medications, sedatives, narcotics, sleeping pills, muscle relaxants, seizure or anxiety medications, other antidepressants, non-steroidal anti-inflammatory drugs (NSAIDs), anticoagulants, cimetidine, fentanyl, St. John’s wort, tramadol, L- tryptophan, heart medications, or migraine medicines.

Zoloft may also interact with digoxin, linezolid, lithium, or valproate.

Do not take Zoloft if you:

• are taking a monoamine oxidase inhibitor (MAOI). If you are not sure if you are taking an MAOI, including the antibiotic linezolid, ask your doctor or pharmacist.
• have taken an MAOI within 2 weeks of stopping Zoloft, unless advised by your healthcare professional.
• have stopped taking an MAOI within the last 2 weeks, unless instructed by your healthcare provider.
• take any other medicines containing sertraline (eg sertraline HCl or sertraline hydrochloride).
• take the antipsychotic drug pimozide (Orap) because it can cause serious heart problems.
• you are allergic to sertraline or any of the ingredients of Zoloft. See the end of this medication guide for a complete list of Zoloft ingredients.
• take Antabuse (disulfiram) (if you are taking liquid Zoloft) because of the alcohol content.

When Zoloft is stopped abruptly, side effects of withdrawal may include abdominal cramps, flu-like symptoms, fatigue, and memory impairment.

How should I take Wellbutrin?

Take Wellbutrin exactly as directed by your doctor.

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• Take Wellbutrin at the same time each day.
• Take doses of Wellbutrin at least 6 hours apart.
• You can take Wellbutrin with or without food.
• If you miss a dose, do not take an extra tablet to make up for the forgotten dose. Wait and take the next tablet at the usual time. It is very important. Too much Wellbutrin can increase the chance of an attack.
• If you take too much Wellbutrin or overdose, call your local emergency room or poison control center right away.
• Do not take any other medicines while using Wellbutrin unless your doctor has told you that this is normal.
• It may take a few weeks before you feel Wellbutrin is working. Once you feel better, it is important to continue taking Wellbutrin exactly as directed by your doctor. Call your doctor if you don’t feel Wellbutrin is right for you.
• Do not change your dose or stop taking Wellbutrin without first talking to your doctor.

How should I take Zoloft?

Take Zoloft exactly as directed. Your doctor may need to change your dose of Zoloft until it is right for you.

Zoloft tablets can be taken with or without food.

Zoloft Oral Solution may look cloudy or cloudy after mixing, this is normal.

Zoloft oral solution must be diluted before use:

Do not mix Zoloft until you are ready to take it.

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When diluting Zoloft Oral Solution, use only water, ginger ale, lemon/lime soda, lemonade, or orange juice.

Oral drip contains latex. If you have a sensitivity or allergy to latex, ask your doctor or pharmacist about the best way to measure your dose.

If you miss a dose of Zoloft, take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose at the usual time. Do not take two doses of Zoloft at the same time.

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If you have taken too much Zoloft, call your doctor or poison control center right away, or go to the nearest hospital right away.

Disclaimer

All drug information provided on RxList.com is obtained directly from drug monographs published by the US Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug use, dosage, etc. is taken from the original drug documentation contained in his FDA drug monograph.

The drug information contained in the drug comparisons published on RxList.com is primarily derived from the FDA drug information. The drug comparison information contained in this article does not contain data from human or animal clinical trials conducted by any of the drug manufacturers comparing drugs.

The drug comparison information provided does not cover all potential uses, warnings, drug interactions, side effects, adverse or allergic reactions. RxList.com is not responsible for the health care provided to a person based on the information posted on this site.

Because drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the fact that drug information is time dependent, RxList.com makes no guarantee that the information provided is the latest.

The absence of drug warnings or information does not in any way guarantee the safety, efficacy or absence of side effects of any medicine. The medication information provided is for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding drug safety, side effects, uses, warnings, etc., you should ask your doctor or pharmacist or refer to specific drug details found on the FDA websites .gov or RxList.com for more information. .

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You can also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or by calling 1-800-FDA-1088.