What are the primary uses of famciclovir 500mg. How does famciclovir work against viral infections. What are the common side effects of famciclovir. How should famciclovir be taken for optimal effectiveness. What precautions should be considered when using famciclovir.

Understanding Famciclovir: An Antiviral Powerhouse

Famciclovir is a potent antiviral medication used to combat various herpes virus infections. This 500mg oral formulation is particularly effective in treating and managing several conditions caused by herpes simplex and herpes zoster viruses. While it doesn’t cure these viral infections, famciclovir plays a crucial role in reducing their severity and frequency.

Key Functions of Famciclovir

• Treats shingles (herpes zoster)
• Manages cold sores and genital herpes (herpes simplex)
• Reduces frequency of recurrent genital herpes outbreaks
• Decreases pain and itching associated with outbreaks
• Accelerates healing of sores
• Prevents new sores from forming

Is famciclovir a cure for herpes infections? No, famciclovir is not a cure. The viruses remain dormant in the body between outbreaks. However, famciclovir effectively manages symptoms and reduces the virus’s impact on the patient’s quality of life.

The Science Behind Famciclovir’s Effectiveness

Famciclovir belongs to a class of medications known as antiviral drugs. Its mechanism of action involves interfering with the virus’s ability to replicate, thereby limiting the spread and severity of the infection. This process is particularly beneficial for immunocompromised individuals, as it helps prevent the virus from causing more serious complications.

How does famciclovir compare to other antiviral medications? While famciclovir shares similarities with other antivirals like acyclovir and valacyclovir, it has unique properties that make it effective for certain patients. Its absorption and conversion to the active form in the body allow for less frequent dosing in some cases.

Proper Administration of Famciclovir 500mg

To maximize the benefits of famciclovir, it’s crucial to follow the prescribed dosage and timing. The medication is typically taken orally, with or without food, as directed by a healthcare provider.

Dosage Guidelines

1. Typically prescribed 2 to 3 times daily
2. Dosage based on specific medical condition and patient response
3. Best results achieved when started at the first sign of an outbreak
4. Continuous treatment until the full prescribed amount is finished

Why is timing important when taking famciclovir? Starting treatment at the earliest signs of an outbreak can significantly reduce the severity and duration of symptoms. Delaying treatment may result in diminished effectiveness.

Navigating Potential Side Effects

While famciclovir is generally well-tolerated, like all medications, it can cause side effects in some individuals. Understanding these potential effects can help patients manage their treatment more effectively.

Common Side Effects

• Headache
• Nausea
• Diarrhea

Serious Side Effects (Rare)

• Mental/mood changes (agitation, confusion, hallucinations)
• Dizziness or drowsiness
• Signs of kidney problems
• Yellowing of eyes/skin
• Easy bruising/bleeding

When should a patient seek medical attention for side effects? If any side effects persist or worsen, it’s important to consult a healthcare provider promptly. Severe allergic reactions, while rare, require immediate medical attention.

Essential Precautions and Interactions

Before starting famciclovir treatment, it’s crucial to inform your healthcare provider about your medical history, especially regarding kidney problems or allergies. This information helps in determining the appropriate dosage and identifying potential risks.

Key Considerations

• Inform healthcare providers about all medications and supplements being taken
• Avoid driving or operating machinery if experiencing dizziness or drowsiness
• Limit alcohol consumption
• Consult a doctor before receiving certain immunizations or vaccinations
• Use caution if you have lactose intolerance, as the medication may contain lactose

Can famciclovir interact with other medications? Yes, famciclovir can interact with various drugs. It’s essential to provide a complete list of all medications, including over-the-counter drugs and herbal supplements, to your healthcare provider to avoid potential interactions.

Famciclovir in Special Populations

The use of famciclovir may require special considerations in certain groups of patients. These include older adults, individuals with kidney problems, and those with weakened immune systems.

Considerations for Older Adults

• May be more sensitive to side effects
• Increased risk of dizziness, drowsiness, and confusion
• Potential for changes in kidney function affecting drug clearance

Patients with Kidney Issues

• May require dose adjustments
• Closer monitoring of kidney function during treatment

Immunocompromised Individuals

• May benefit from famciclovir’s ability to prevent virus spread to other body parts
• Might require different dosing strategies

How does kidney function affect famciclovir dosing? Kidney function plays a crucial role in the elimination of famciclovir from the body. Patients with impaired kidney function may require lower doses or less frequent administration to prevent drug accumulation and potential side effects.

Famciclovir’s Role in Managing Chronic Herpes Infections

For individuals with frequent outbreaks of genital herpes, famciclovir can play a significant role in suppressive therapy. This approach involves taking the medication regularly to reduce the frequency and severity of future episodes.

Benefits of Suppressive Therapy

• Fewer outbreaks over time
• Reduced viral shedding
• Improved quality of life
• Potential reduction in transmission risk to partners

Is suppressive therapy with famciclovir suitable for everyone with recurrent herpes? While many patients benefit from suppressive therapy, the decision to use this approach should be made in consultation with a healthcare provider. Factors such as outbreak frequency, severity, and overall health are considered when determining the appropriateness of suppressive therapy.

Comparing Famciclovir to Other Antiviral Treatments

Famciclovir is one of several antiviral medications used to treat herpes infections. Understanding how it compares to other options can help patients and healthcare providers make informed treatment decisions.

Famciclovir vs. Acyclovir

• Famciclovir often requires less frequent dosing
• May have better bioavailability
• Both effective against various herpes viruses

Famciclovir vs. Valacyclovir

• Similar efficacy in treating herpes infections
• Dosing frequency may differ depending on the specific condition
• Both are prodrugs, converted to active forms in the body

Which antiviral is most effective for treating herpes infections? The effectiveness of antiviral medications can vary among individuals. Factors such as the specific virus, outbreak frequency, and patient characteristics influence the choice of treatment. Healthcare providers consider these factors when recommending the most suitable antiviral therapy.

Future Perspectives: Advancements in Antiviral Therapy

As research in antiviral treatments continues to evolve, new approaches to managing herpes infections are being explored. While famciclovir remains a valuable treatment option, ongoing studies aim to enhance its efficacy and develop novel therapies.

Emerging Research Areas

• Combination therapies with other antivirals
• Development of longer-acting formulations
• Exploration of immune-modulating approaches
• Investigation of potential herpes vaccines

How might future advancements impact the use of famciclovir? While famciclovir continues to be an effective treatment, future developments could lead to more targeted therapies, reduced dosing frequencies, or even preventive measures against herpes infections. Ongoing research aims to improve patient outcomes and quality of life for those affected by herpes viruses.

In conclusion, famciclovir 500mg stands as a powerful tool in the management of herpes virus infections. Its ability to reduce outbreak severity, accelerate healing, and prevent recurrences makes it a valuable option for many patients. While not a cure, famciclovir significantly improves the quality of life for those affected by herpes infections. As with any medication, it’s crucial to use famciclovir under the guidance of a healthcare provider, adhering to prescribed dosages and being aware of potential side effects and interactions. The ongoing advancements in antiviral research promise even more effective treatments in the future, but for now, famciclovir remains a cornerstone in herpes management strategies.

Famciclovir Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

Famciclovir is used to treat infections caused by certain types of viruses. It treats shingles caused by herpes zoster. It also treats outbreaks of herpes simplex that cause cold sores around the mouth, sores around the anus, and genital herpes. In people with frequent outbreaks of genital herpes, famciclovir is used to help reduce the number of future episodes.Famciclovir is an antiviral drug. However, it is not a cure for these infections. The viruses that cause these infections continue to live in the body even between outbreaks. Famciclovir decreases the severity and length of these outbreaks. It helps the sores heal faster, keeps new sores from forming, and decreases pain/itching. This medication may also help reduce how long pain remains after the sores heal. In addition, in people with a weakened immune system, famciclovir can decrease the risk of the virus spreading to other parts of the body and causing serious infections.

How to use Famciclovir

Read the Patient Information Leaflet if available from your pharmacist before you start taking famciclovir and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually 2 to 3 times a day.

This medication works best when started at the first sign of an outbreak, as directed by your doctor. It may not work as well if you delay treatment.

The dosage is based on your medical condition and response to treatment.

This medication works best when the amount of drug in your body is kept at a constant level. Take this drug at evenly spaced intervals. To help you remember, take it at the same times each day.

Continue to take this medication until the full prescribed amount is finished. Do not change your dose, skip any doses, or stop this medication early without your doctor’s approval.

Tell your doctor if your condition lasts or gets worse.

Side Effects

Headache, nausea, and diarrhea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as agitation, slowed thinking, confusion, hallucinations), dizziness, drowsiness, signs of kidney problems (such as change in the amount of urine), yellowing eyes/skin, easy bruising/bleeding.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking famciclovir, tell your doctor or pharmacist if you are allergic to it; or to penciclovir; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems.

This drug may rarely make you dizzy or drowsy. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

This medication may contain lactose. If you have certain conditions such as galactose intolerance, severe lactase deficiency (not lactose or milk intolerance), or glucose-galactose malabsorption that require you to restrict your intake of lactose, consult your doctor or pharmacist before taking this medication.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Do not have certain immunizations/vaccinations (such as vaccines against the varicella virus) without the consent of your doctor.

Older adults may be more sensitive to the side effects of this drug, especially dizziness, drowsiness, confusion, and change in the amount of urine (kidney problems).

Famciclovir does not protect against the spread of genital herpes. To lower the chance of giving herpes to your partner, do not have sexual contact during an outbreak or if you have symptoms. You can spread genital herpes even if you do not have symptoms. Always use an effective barrier method (latex or polyurethane condoms/dental dams) during all sexual activity. Consult your doctor or pharmacist for more details.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. It may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.

Does Famciclovir interact with other drugs you are taking?

Enter your medication into the WebMD interaction checker

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

This medication has been prescribed for your current condition only. Do not use it later for another infection unless your doctor tells you to.

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

famciclovir 500 mg tablet

Color: whiteShape: ovalImprint: APO FAM 500

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 125 mg tablet

Color: whiteShape: roundImprint: APO FAM 125

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 500 mg tablet

Color: whiteShape: oblongImprint: C272

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 125 mg tablet

Color: whiteShape: roundImprint: C 269

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 250 mg tablet

Color: whiteShape: roundImprint: C 271

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 250 mg tablet

Color: whiteShape: roundImprint: APO FAM 250

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 500 mg tablet

Color: whiteShape: oblongImprint: 8119 93

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 250 mg tablet

Color: whiteShape: roundImprint: X 49

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 250 mg tablet

Color: whiteShape: roundImprint: 8118 93

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 125 mg tablet

Color: whiteShape: roundImprint: 8117 93

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 500 mg tablet

Color: whiteShape: ovalImprint: ML 72

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 125 mg tablet

Color: whiteShape: roundImprint: ML 67

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 250 mg tablet

Color: whiteShape: roundImprint: ML 70

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 500 mg tablet

Color: off-whiteShape: ovalImprint: I 48

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 250 mg tablet

Color: off-whiteShape: roundImprint: I 49

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 125 mg tablet

Color: off-whiteShape: roundImprint: I 50

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 500 mg tablet

Color: whiteShape: ovalImprint: X 34

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

famciclovir 125 mg tablet

Color: whiteShape: roundImprint: X 48

This medicine is a white, oval, film-coated, tablet imprinted with “APO” and “FAM 500”.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

Famciclovir Uses, Side Effects & Warnings

Generic name: famciclovir [ fam-SYE-klo-veer ]
Brand name: Famvir
Dosage form: oral tablet (125 mg; 250 mg; 500 mg)
Drug class: Purine nucleosides

Medically reviewed by Drugs. com on Jun 3, 2022. Written by Cerner Multum.

What is famciclovir?

Famciclovir is an antiviral medicine that is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles.

Famciclovir is sometimes used in people with human immunodeficiency virus (HIV) who develop herpes outbreaks around the mouth, genitals, or anal area.

Famciclovir may not be effective in treating your first episode of genital herpes, but may help prevent future episodes. Famciclovir also may not be effective in Black or African-American people with genital herpes, and may not be effective in any person with shingles (herpes zoster) affecting the eyes.

There is no cure for herpes and famciclovir will not prevent you from developing symptoms in the future.

Famciclovir may also be used for purposes not listed in this medication guide.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Before taking this medicine

You should not use famciclovir if you are allergic to famciclovir or penciclovir cream (Denavir).

Tell your doctor if you have ever had:

• liver disease;

• kidney disease;

• a weak immune system;

• galactose intolerance;

• severe lactase deficiency; or

• glucose-galactose malabsorption.

Tell your doctor if you are pregnant or plan to become pregnant. Herpes can be passed to your baby during childbirth if you have a genital lesion when your baby is born. If you have genital herpes, it is very important to prevent herpes lesions during pregnancy. Take your medicine as directed to best control your infection.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of famciclovir on the baby.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

Famciclovir is not approved for use by anyone younger than 18 years old.

How should I take famciclovir?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Taking more famciclovir than prescribed will not make this medicine more effective

For cold sores or genital herpes, you should start taking famciclovir as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

You may take famciclovir with or without food.

Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions.

To prevent recurrent genital herpes, you may need to take famciclovir for up to 1 year. Follow your doctor’s instructions.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses may increase the risk of your virus becoming resistant to medication.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking famciclovir?

Taking famciclovir will not prevent you from passing genital herpes to other people. Herpes infections are contagious and you can infect other people even while you are taking famciclovir.

Avoid driving or hazardous activity until you know how this medicine will affect you. Your reactions could be impaired.

Avoid sexual intercourse or use a latex condom to help keep you from spreading the virus to others. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent the spread of infection.

Famciclovir side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Famciclovir may cause serious side effects. Call your doctor at once if you have:

Common side effects of famciclovir may include:

• headache; or

• nausea.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Famciclovir dosing information

Usual Adult Dose for Herpes Simplex — Mucocutaneous/Immunocompetent Host:

Genital herpes:
Initial episode: 250 mg orally 3 times a day for 7 to 10 days has been recommended by the US Centers for Disease Control and Prevention (CDC)

Recurrent episodes: 1000 mg orally twice a day for 1 day; alternatively, 125 mg orally twice a day for 5 days has been recommended by the CDC

Famciclovir should be started at the first sign or symptom of a recurrent episode (such as tingling, burning, itching, pain, or lesion). The efficacy has not been established if started more than 6 hours after onset of symptoms or lesions.

Usual Adult Dose for Herpes Simplex — Mucocutaneous/Immunocompromised Host:

Recurrent episodes of orolabial or genital herpes in HIV-infected patients: 500 mg orally twice a day for 7 days (5 to 10 days recommended by the CDC)

Famciclovir should be started at the first sign or symptom of a recurrent episode (such as tingling, burning, itching, pain, or lesion). The efficacy has not been established if started more than 48 hours after onset of symptoms or lesions.

Usual Adult Dose for Herpes Simplex — Suppression:

Chronic suppression of recurrent genital herpes:
Immunocompetent patients: 250 mg orally twice a day
HIV-infected patients: 500 mg orally twice a day has been recommended by the CDC

Therapy should be continued as clinically appropriate, although the safety and efficacy of famciclovir therapy beyond 1 year have not been established.

Usual Adult Dose for Herpes Zoster:

500 mg orally every 8 hours for 7 days

Famciclovir is most effective if started within 48 hours of onset of rash. The efficacy has not been established if started more than 72 hours after onset of rash.

Usual Adult Dose for Herpes Simplex Labialis:

Recurrent herpes labialis: 1500 mg orally as a single dose

Famciclovir is most effective if started at the earliest sign or symptom of a cold sore (such as tingling, burning, itching, pain, or lesion).

What other drugs will affect famciclovir?

Other drugs may affect famciclovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

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Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Copyright 1996-2023 Cerner Multum, Inc. Version: 5.01.

film-coated tablets, 500 mg

1 tab. Active ingredient: famciclovir 125 mg 250 mg 500 mg excipients: sodium starch glycolate – 8.26 / 16.52 / 27.35 mg; hydroxypropylcellulose – 3.86 / 7.73 / 15.48 mg; anhydrous lactose — 26.85/53.69/- mg; magnesium stearate – 1.24 / 2.48 / 4.1 mg shell (Opadry OY-S-28924): hypromellose 2.42/4.84/8.01 mg; titanium dioxide – 0.99 / 1.98 / 3.28 mg; polyethylene glycol 4000 – 0.36 / 0.72 / 1.2 mg; polyethylene glycol 6000 – 0.36 / 0.72 / 1.2 mg

Inside, regardless of the meal, without chewing, drinking water. Treatment with the drug should be started as early as possible, immediately after the first symptoms of the disease appear (tingling, itching and burning).

Varicella zoster virus (shingles) infection in immunocompetent patients. The recommended dose is 500 mg 3 times a day for 7 days. This method of application can reduce the duration of postherpetic neuralgia. In the acute phase of the disease, to resolve skin manifestations, the recommended dose is 250 mg 3 times a day or 500 mg 2 times a day or 750 mg 1 time a day for 7 days.

Varicella zoster virus ophthalmoherpes in immunocompetent patients. The recommended dose is 500 mg 3 times a day for 7 days.

Varicella zoster virus (shingles) infection in immunocompromised patients. The recommended dose is 500 mg 3 times a day for 10 days.

Herpes simplex virus infection (labial or genital herpes) in immunocompetent patients. For primary genital herpes, the recommended dose is 250 mg 3 times a day for 5 days. For recurrences of genital herpes, 1000 mg 2 times a day for 1 day or 125 mg 2 times a day for 5 days or 500 mg once, followed by 3 doses of 250 mg every 12 hours are prescribed. For relapses of labial herpes – 1500 mg once within 1 day or 750 mg 2 times a day for 1 day.

Herpes simplex virus infection (labial or genital herpes) in immunocompromised patients. The recommended dose is 500 mg twice daily for 7 days.

For the prevention of exacerbations of recurrent Herpes simplex infection – suppressive therapy – 250 mg 2 times a day. The duration of therapy depends on the severity of the disease. Periodic assessment of possible changes in the course of the disease after 12 months is recommended. In HIV-infected patients, the effective dose is 500 mg 2 times a day.

Patients ≥65 years of age. Elderly patients with normal renal function do not require dose adjustment of famciclovir.

Patients with impaired renal function. In patients with impaired renal function, there is a decrease in the clearance of penciclovir. Correction of the dosing regimen depending on Cl creatinine is presented in the tables.

Table 1

Correction of dosing regimen depending on creatinine Cl in infection caused by virus Varicella zoster (herpes zoster), in immunocompetent patients

Dosing regimen for 7 days	Cl creatinine, ml/min	Adjusted dosing schedule for 7 days
500 mg 3 times a day	?60	500 mg 3 times a day
	40-59	500 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session
250 mg 3 times a day	?40	250 mg 3 times a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session
500 mg twice daily	?40	500 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session
750 mg once a day	?40	750 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session

Table 2

Correction of dosing regimen depending on creatinine Cl in case of infection caused by the virus Varicella zoster (herpes zoster), in immunocompromised patients

Dosing schedule for 10 days	Cl creatinine, ml/min	Adjusted dosing regimen for 10 days
500 mg 3 times a day	?60	500 mg 3 times a day
	40-59	500 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session

Table 3

Correction of dosing regimen depending on creatinine Cl in case of infection caused by Herpes simplex virus in patients with normal immunity

Dosing regimen 9 0010	Cl creatinine, ml/min	Adjusted dosage regimen
First episode
250 mg 3 times daily for 5 days	?40	250 mg 3 times a day for 5 days
	20-39	250 mg twice daily for 5 days
	<20	250 mg once daily for 5 days
	Hemodialysis patients	250 mg after each dialysis session for 5 days
For recurrent genital herpes
1000 mg twice daily for 1 day	?60	1000 mg twice daily for 1 day
	40-59	500 mg twice daily for 1 day
	20-39	500 mg single dose
	<20	250 mg single dose
	Hemodialysis patients	250 mg once after dialysis session
125 mg twice a day for 5 days	?20	125 mg twice daily for 5 days
	<20	125 mg single dose
	Hemodialysis patients	125 mg after each dialysis session for 5 days
500 mg once followed by 3 doses of 250 mg every 12 hours	?40	500 mg once followed by 3 doses of 250 mg every 12 hours
	20-39	250 mg once followed by 3 doses of 250 mg every 12 hours
	<20	250 mg once followed by 250 mg every other day
	Hemodialysis patients	250 mg once after dialysis session
For relapses of herpes labialis
1500 mg once	?60	1500 mg single dose
	40-59	750 mg single dose
	20-39	500 mg single dose
	<20	250 mg single dose
	Hemodialysis patients	250 mg once after dialysis session
750 mg twice a day	?60	750 mg twice daily for 1 day
	40-59	750 mg single dose
	20-39	500 mg single dose
	<20	250 mg single dose
	Hemodialysis patients	250 mg once after dialysis session

Table 4

Correction of the dosing regimen depending on creatinine Cl in the prevention of exacerbations of recurrent infection caused by the Herpes simplex virus (suppressive therapy)

Dosing regimen	Cl creatinine, ml/min	Adjusted dosage regimen
250 mg twice daily	?40	250 mg twice daily
	20-39	125 mg twice a day
	<20	125 mg once daily
	Hemodialysis patients	125 mg after each dialysis session

Table 5

Correction of dosing regimen depending on creatinine Cl in infection caused by the Herpes simplex virus (labial or genital herpes), in immunocompromised patients

Dosing schedule for 7 days	Cl creatinine, ml/min	Adjusted dosing schedule for 7 days
500 mg twice daily	?40	500 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session

Renal failure patients on hemodialysis. Since plasma concentrations of penciclovir are reduced by 75% after 4 hours of hemodialysis, famciclovir should be taken immediately after hemodialysis. The recommended dose is 250 mg (for patients with herpes zoster) and 125 mg (for patients with genital herpes).

Patients with impaired liver function. For patients with mild to moderate hepatic impairment, dose adjustment is not required.

Black patients. The effectiveness of one-day administration of Famvir ^® at a dose of 1000 mg 2 times a day for the treatment of recurrence of genital herpes in immunocompetent patients of the black race did not exceed that for placebo. Clinical significance of dosing regimens for the treatment of both recurrence of genital herpes (within 2 or 5 days) and other infectious lesions caused by viruses Varicella zoster and Herpes simplex unknown.

At a temperature not exceeding 25 °C, in the original packaging.

Keep out of reach of children.

Famvir, 500 mg, coated tablets, 3 pcs.

Inside, regardless of the meal, without chewing, drinking water. Treatment with the drug should be started as early as possible, immediately after the first symptoms of the disease appear (tingling, itching and burning).

Varicella zoster virus (shingles) infection in immunocompetent patients. The recommended dose is 500 mg 3 times a day for 7 days. This method of application can reduce the duration of postherpetic neuralgia. In the acute phase of the disease, to resolve skin manifestations, the recommended dose is 250 mg 3 times a day or 500 mg 2 times a day or 750 mg 1 time a day for 7 days.

Varicella zoster virus ophthalmoherpes in immunocompetent patients. The recommended dose is 500 mg 3 times a day for 7 days.

Varicella zoster virus (shingles) infection in immunocompromised patients. The recommended dose is 500 mg 3 times a day for 10 days.

Herpes simplex virus infection (labial or genital herpes) in immunocompetent patients. For primary genital herpes, the recommended dose is 250 mg 3 times a day for 5 days. For recurrences of genital herpes, 1000 mg 2 times a day for 1 day or 125 mg 2 times a day for 5 days or 500 mg once, followed by 3 doses of 250 mg every 12 hours are prescribed. For relapses of labial herpes – 1500 mg once within 1 day or 750 mg 2 times a day for 1 day.

Herpes simplex virus infection (labial or genital herpes) in immunocompromised patients. The recommended dose is 500 mg twice daily for 7 days.

For the prevention of exacerbations of recurrent Herpes simplex infection – suppressive therapy – 250 mg 2 times a day. The duration of therapy depends on the severity of the disease. Periodic assessment of possible changes in the course of the disease after 12 months is recommended. In HIV-infected patients, the effective dose is 500 mg 2 times a day.

Patients ≥65 years of age. Elderly patients with normal renal function do not require dose adjustment of famciclovir.

Patients with impaired renal function. In patients with impaired renal function, there is a decrease in the clearance of penciclovir. Correction of the dosing regimen depending on Cl creatinine is presented in the tables.

Table 1

Correction of dosing regimen depending on creatinine Cl in infection caused by virus Varicella zoster (herpes zoster), in immunocompetent patients

Dosing regimen for 7 days	Cl creatinine, ml/min	Adjusted dosing schedule for 7 days
500 mg 3 times a day	≥60	500 mg 3 times a day
	40-59	500 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session
250 mg 3 times a day	≥40	250 mg 3 times a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session
500 mg twice daily	≥40	500 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session
750 mg once a day	≥40	750 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session

Table 2

Correction of the dosing regimen depending on creatinine Cl in case of infection caused by the virus Varicella zoster (herpes zoster) in immunocompromised patients

Dosing schedule for 10 days	Cl creatinine, ml/min	Adjusted dosing regimen for 10 days
500 mg 3 times a day	≥60	500 mg 3 times a day
	40-59	500 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session

Table 3

Correction of dosing regimen depending on creatinine Cl in case of infection caused by Herpes simplex virus in patients with normal immunity

Dosing regimen 9 0010	Cl creatinine, ml/min	Adjusted dosage regimen
First episode
250 mg 3 times daily for 5 days	≥40	250 mg 3 times a day for 5 days
	20-39	250 mg twice daily for 5 days
	<20	250 mg once daily for 5 days
	Hemodialysis patients	250 mg after each dialysis session for 5 days
For recurrent genital herpes
1000 mg twice daily for 1 day	≥60	1000 mg twice daily for 1 day
	40-59	500 mg twice daily for 1 day
	20-39	500 mg single dose
	<20	250 mg single dose
	Hemodialysis patients	250 mg once after dialysis session
125 mg twice daily for 5 days	≥20	125 mg twice daily for 5 days
	<20	125 mg single dose
	Hemodialysis patients	125 mg after each dialysis session for 5 days
500 mg once followed by 3 doses of 250 mg every 12 hours	≥40	500 mg once followed by 3 doses of 250 mg every 12 hours
	20-39	250 mg once followed by 3 doses of 250 mg every 12 hours
	<20	250 mg once followed by 250 mg every other day
	Hemodialysis patients	250 mg once after dialysis session
For relapses of herpes labialis
1500 mg once	≥60	1500 mg single dose
	40-59	750 mg single dose
	20-39	500 mg single dose
	<20	250 mg single dose
	Hemodialysis patients	250 mg once after dialysis session
750 mg twice a day	≥60	750 mg twice daily for 1 day
	40-59	750 mg single dose
	20-39	500 mg single dose
	<20	250 mg single dose
	Hemodialysis patients	250 mg once after dialysis session

Table 4

Correction of the dosing regimen depending on creatinine Cl in the prevention of exacerbations of recurrent infection caused by virus Herpes simplex (suppressive therapy)

Dosing regimen	Cl creatinine, ml/min	Adjusted dosage regimen
250 mg twice daily	≥40	250 mg twice daily
	20-39	125 mg twice a day
	<20	125 mg once daily
	Hemodialysis patients	125 mg after each dialysis session

Table 5

Correction of the dosing regimen depending on creatinine Cl in infection caused by the Herpes simplex virus (labial or genital herpes), in immunocompromised patients

9000 8

Dosing schedule for 7 days	Cl creatinine, ml/min	Adjusted dosing schedule for 7 days
500 mg twice a day	≥40	500 mg twice a day
	20-39	500 mg once daily
	<20	250 mg once daily
	Hemodialysis patients	250 mg after each dialysis session

Renal failure patients on hemodialysis.