What is the side effect of cytotec. Cytotec (Misoprostol): Uses, Side Effects, and Crucial Precautions
What are the primary uses of Cytotec. How does misoprostol work to prevent stomach ulcers. What are the most common side effects of Cytotec. Why is Cytotec contraindicated during pregnancy. How should Cytotec be taken for optimal effectiveness. What precautions should be taken when using misoprostol. Who should avoid taking Cytotec.
Understanding Cytotec: A Comprehensive Overview
Cytotec, also known by its generic name misoprostol, is a medication that serves multiple purposes in medical practice. Its primary function is to prevent stomach ulcers in patients who are taking nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen. However, it’s crucial to understand the full scope of this medication, including its uses, side effects, and important precautions.
The Primary Uses of Cytotec (Misoprostol)
Cytotec is primarily prescribed for two main purposes:
- Prevention of stomach ulcers in patients taking NSAIDs
- Inducing labor or terminating pregnancy (in combination with mifepristone)
How does Cytotec work to prevent stomach ulcers? The medication protects the stomach lining by reducing the amount of acid that comes into contact with it. This mechanism of action is particularly beneficial for patients who are at high risk of developing ulcers or have a history of ulcers.
Proper Administration and Dosage of Cytotec
The correct administration of Cytotec is crucial for its effectiveness and safety. Here are the key points to remember:
- For ulcer prevention: Take orally, usually four times a day
- Timing: Take after meals and at bedtime to minimize diarrhea
- Dosage: Based on medical condition and response to therapy
- Duration: Continue taking for as long as you’re using NSAIDs
- Consistency: Use regularly at the same times each day for maximum benefit
Can Cytotec be used with antacids? It’s important to avoid antacids containing magnesium while using misoprostol, as they may exacerbate diarrhea. If you need an antacid, consult your healthcare provider for a suitable alternative.
Side Effects and Risks Associated with Cytotec
While Cytotec can be an effective medication for its intended purposes, it’s not without potential side effects. Common side effects may include:
- Diarrhea
- Abdominal pain
- Nausea
- Headache
- Dizziness
Are there any serious risks associated with Cytotec use? In rare cases, particularly when used to induce labor or terminate pregnancy, serious complications such as uterine rupture can occur. These complications can potentially harm both the mother and the unborn child.
Increased Risk Factors for Uterine Rupture
The risk of uterine rupture increases with:
- Advanced stages of pregnancy
- Prior uterine surgery (including Cesarean delivery)
- Five or more previous pregnancies
Crucial Precautions and Contraindications for Cytotec Use
The use of Cytotec comes with several important precautions and contraindications that must be strictly adhered to:
Pregnancy and Cytotec
Why is Cytotec strictly contraindicated during pregnancy? Misoprostol can cause serious harm to an unborn baby, including:
- Termination of pregnancy
- Premature birth
- Birth defects
It’s crucial to avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after stopping treatment. If pregnancy occurs during treatment, immediate medical consultation is necessary.
Special Precautions for Women of Childbearing Age
For women of childbearing age, specific requirements must be met before using Cytotec:
- Negative pregnancy test within two weeks before starting treatment
- Use of effective birth control methods
- Receipt of oral and written warnings about the dangers of misoprostol use
- Initiation of misoprostol only on the second or third day of the next normal menstrual period
Interactions and Contraindications with Other Medications
Cytotec may interact with other medications, potentially altering their effectiveness or increasing the risk of side effects. It’s important to inform your healthcare provider about all medications you’re taking, including over-the-counter drugs and supplements.
NSAIDs and Cytotec
While Cytotec is often prescribed to prevent ulcers caused by NSAIDs, there are specific considerations:
- Pregnant women should not take Cytotec to reduce the risk of stomach ulcers due to NSAID use
- Women of childbearing age should only use Cytotec with NSAIDs if they’re at high risk of ulcers or ulcer complications
Monitoring and Follow-up During Cytotec Treatment
Regular monitoring and follow-up are essential components of Cytotec treatment. This may include:
- Periodic check-ups with your healthcare provider
- Regular pregnancy tests for women of childbearing age
- Monitoring for side effects and complications
- Adjusting dosage as needed based on response to treatment
How often should follow-up appointments be scheduled? The frequency of follow-up appointments will depend on individual circumstances and should be determined by your healthcare provider.
Alternative Treatments and Considerations
While Cytotec can be an effective medication for its intended purposes, it’s not suitable for everyone. Alternative treatments may be considered in certain cases:
Alternatives for Ulcer Prevention
- Proton pump inhibitors (PPIs)
- H2 receptor antagonists
- Lifestyle modifications (e.g., dietary changes, stress reduction)
Alternatives for Labor Induction
- Oxytocin
- Mechanical methods (e.g., balloon catheter)
- Prostaglandin E2
What factors should be considered when choosing between Cytotec and alternative treatments? The choice of treatment should be based on individual medical history, risk factors, and the specific medical condition being addressed. Always consult with a healthcare professional to determine the most appropriate treatment option.
Long-term Implications and Considerations of Cytotec Use
Understanding the long-term implications of Cytotec use is crucial for patients and healthcare providers alike. While the medication can be highly effective for its intended purposes, it’s important to consider potential long-term effects and ongoing management strategies.
Long-term Effects on Gastrointestinal Health
For patients using Cytotec to prevent NSAID-induced ulcers, long-term use may have implications for overall gastrointestinal health:
- Potential changes in gut microbiome
- Alterations in stomach acid production
- Possible impacts on nutrient absorption
How can patients mitigate potential long-term gastrointestinal effects? Regular check-ups, maintaining a balanced diet, and discussing any persistent symptoms with a healthcare provider are key strategies for managing long-term gastrointestinal health while on Cytotec.
Reproductive Health Considerations
For women who have used Cytotec for labor induction or pregnancy termination, there may be considerations regarding future reproductive health:
- Potential impact on future pregnancies
- Possible changes in menstrual cycles
- Need for additional monitoring in subsequent pregnancies
It’s crucial for women who have used Cytotec to discuss their medical history with healthcare providers when planning future pregnancies or experiencing reproductive health concerns.
Patient Education and Empowerment
Empowering patients with knowledge about Cytotec is essential for ensuring safe and effective use of the medication. Key aspects of patient education include:
Understanding the Medication
- Mechanism of action
- Expected benefits and potential risks
- Proper administration and dosage
Recognizing Warning Signs
Patients should be educated on recognizing signs that may indicate complications or adverse reactions, such as:
- Severe abdominal pain
- Prolonged or heavy bleeding
- Signs of allergic reaction
- Unexpected changes in menstrual cycle
Importance of Adherence and Communication
Emphasizing the importance of medication adherence and open communication with healthcare providers is crucial. Patients should be encouraged to:
- Take the medication as prescribed
- Report any side effects or concerns promptly
- Discuss any changes in their medical history or other medications
- Ask questions about their treatment plan
How can healthcare providers effectively educate patients about Cytotec? Utilizing a combination of verbal explanations, written materials, and follow-up discussions can help ensure patients fully understand their medication regimen and associated considerations.
Navigating Ethical and Legal Considerations
The use of Cytotec, particularly for pregnancy termination, can involve complex ethical and legal considerations. It’s important for both healthcare providers and patients to be aware of these aspects:
Ethical Considerations
- Balancing patient autonomy with medical ethics
- Addressing cultural and religious perspectives
- Ensuring informed consent
Legal Framework
The legal status of Cytotec use, especially for pregnancy termination, can vary significantly between jurisdictions. Key points to consider include:
- Local and national laws regarding pregnancy termination
- Regulations on off-label use of medications
- Reporting requirements for healthcare providers
How can healthcare providers navigate these ethical and legal considerations? Staying informed about current laws and regulations, maintaining open communication with patients, and consulting with ethics committees when necessary are crucial steps in navigating these complex issues.
Future Directions and Research
As medical science continues to advance, ongoing research into Cytotec and its uses may lead to new insights and applications. Some areas of current and future research include:
Optimizing Dosage and Administration
- Exploring alternative dosing regimens
- Investigating new delivery methods
- Studying combination therapies
Expanding Applications
Researchers are exploring potential new uses for Cytotec, including:
- Treatment of postpartum hemorrhage
- Management of certain gynecological conditions
- Potential applications in other medical fields
Long-term Safety Studies
Ongoing research is focusing on the long-term safety profile of Cytotec, particularly for extended use in ulcer prevention. These studies aim to provide more comprehensive data on:
- Long-term gastrointestinal effects
- Potential impacts on overall health
- Safety in specific patient populations
What potential advancements in Cytotec use can we expect in the coming years? While it’s difficult to predict specific outcomes, continued research may lead to more targeted applications, improved safety profiles, and potentially new formulations or delivery methods for this versatile medication.
Global Perspectives on Cytotec Use
The use of Cytotec varies significantly across different countries and healthcare systems. Understanding these global perspectives can provide valuable insights into the medication’s role in various contexts:
Availability and Regulation
- Variations in approval status across countries
- Differences in regulatory frameworks
- Impact of cultural and social factors on availability
Clinical Practice Variations
The use of Cytotec in clinical practice can differ based on regional guidelines and healthcare systems:
- Variations in prescribing patterns
- Differences in monitoring protocols
- Alternative treatments preferred in certain regions
Access and Affordability
Global disparities in access to Cytotec and alternative treatments can have significant implications:
- Availability in low-resource settings
- Impact of cost on treatment decisions
- Role of international organizations in improving access
How do these global variations impact patient care and outcomes? Understanding these differences can help inform policy decisions, improve global health strategies, and promote equitable access to essential medications like Cytotec.
Cytotec in the Context of Women’s Health
While Cytotec has applications beyond women’s health, its use in obstetrics and gynecology warrants special attention:
Reproductive Health Applications
- Management of miscarriage
- Cervical ripening before gynecological procedures
- Treatment of postpartum hemorrhage
Balancing Benefits and Risks
The use of Cytotec in women’s health requires careful consideration of potential benefits and risks:
- Efficacy in various gynecological applications
- Potential impacts on future fertility
- Psychological considerations, particularly in pregnancy termination
Patient-Centered Care
Emphasizing patient-centered care is crucial when using Cytotec in women’s health contexts:
- Importance of informed decision-making
- Providing comprehensive counseling and support
- Addressing individual patient needs and preferences
How can healthcare providers ensure that the use of Cytotec in women’s health is both effective and patient-centered? By combining evidence-based practice with compassionate care, providers can optimize the use of Cytotec while prioritizing patient well-being and autonomy.
Cytotec Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing
Warnings:
Do not take this medication if you think that you may be pregnant. It may cause a pregnancy to end, premature birth, or birth defects. In rare cases, serious complications (such as uterine rupture) have occurred when misoprostol was used to start labor or end a pregnancy. These complications have resulted in harm to the unborn baby and mother. The risk for uterine rupture increases as your pregnancy advances and if you had prior uterine surgery (including Cesarean delivery) or if you had five or more previous pregnancies.
Avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after you have stopped treatment. If you become pregnant while taking misoprostol, contact your doctor right away.
If you are pregnant, do not take this medication to reduce the risk of stomach ulcers due to aspirin or other related drugs (non-steroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Also, if you are of childbearing age, do not use this drug to reduce the risk of ulcers from NSAIDs unless you are at high risk of having an ulcer or ulcer complications.
Female patients must meet the following four requirements in order to use this drug: 1) test negative for pregnancy within two weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) receive oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking misoprostol only on the second or third day of the next normal menstrual period.
This medication must not be shared with others.
Warnings:
Do not take this medication if you think that you may be pregnant. It may cause a pregnancy to end, premature birth, or birth defects. In rare cases, serious complications (such as uterine rupture) have occurred when misoprostol was used to start labor or end a pregnancy. These complications have resulted in harm to the unborn baby and mother. The risk for uterine rupture increases as your pregnancy advances and if you had prior uterine surgery (including Cesarean delivery) or if you had five or more previous pregnancies.
Avoid pregnancy while taking misoprostol and for at least one month or one completed menstrual cycle after you have stopped treatment. If you become pregnant while taking misoprostol, contact your doctor right away.
If you are pregnant, do not take this medication to reduce the risk of stomach ulcers due to aspirin or other related drugs (non-steroidal anti-inflammatory drugs-NSAIDs such as ibuprofen). Also, if you are of childbearing age, do not use this drug to reduce the risk of ulcers from NSAIDs unless you are at high risk of having an ulcer or ulcer complications.
Female patients must meet the following four requirements in order to use this drug: 1) test negative for pregnancy within two weeks before starting treatment; 2) use effective birth control to prevent pregnancy; 3) receive oral and written warnings on the dangers of using misoprostol while of childbearing age and the risks of possible birth control failure; 4) start taking misoprostol only on the second or third day of the next normal menstrual period.
This medication must not be shared with others.
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Uses
This medication is used to prevent stomach ulcers while you take NSAIDs (such as aspirin, ibuprofen, naproxen), especially if you are at risk for developing ulcers or have a history of ulcers. Misoprostol helps to decrease your risk of serious ulcer complications such as bleeding. This medication protects your stomach lining by lowering the amount of acid that comes in contact with it.This medication is also used in combination with another drug (mifepristone) to end a pregnancy.
How to use Cytotec
This medicine comes with a patient information leaflet. Read it carefully. If you have any questions about this drug, ask your doctor, nurse, or pharmacist.
Dosage is based on your medical condition and response to therapy.
If you are taking this drug to prevent stomach ulcers, take it by mouth as directed by your doctor, usually four times a day. Take it after meals and at bedtime to minimize diarrhea.
If you are taking this medication to end a pregnancy, take it by mouth exactly as directed by your doctor.
If you are using this medication to start labor, your healthcare professional will insert it into your vagina.
Avoid taking antacids that contain magnesium while using misoprostol because they may make the diarrhea it causes worse. If you need an antacid, consult your doctor or pharmacist to help you choose a product.
For ulcer prevention, continue to take this drug for as long as you take NSAIDs. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.
Inform your doctor if your condition lasts or gets worse.
Side Effects
Nausea or stomach cramps may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.
Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.
Diarrhea is common with misoprostol and usually occurs about two weeks after you start taking it, and lasts for about a week. Be sure to keep up your intake of fluids and minerals/electrolytes to prevent dehydration. Diarrhea that doesn’t stop may sometimes lead to a large loss of your body’s water and minerals. Tell your doctor right away if you develop any of these serious signs of dehydration and mineral imbalance: dizziness, decreased urination, mental/mood changes, muscle weakness, slow/irregular heartbeat.
Tell your doctor right away if you have any serious side effects, including: menstrual problems or irregularities, unusual/heavy vaginal bleeding.
A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.
This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.
In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Precautions
Before taking misoprostol, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Before using this medication, tell your doctor or pharmacist your medical history, especially of: stomach/intestinal disease (such as inflammatory bowel disease).
Daily use of alcohol and tobacco may increase your risk for stomach bleeding. Limit alcohol beverages and stop smoking. Consult your doctor or pharmacist for more information.
If you are taking this medication in combination with mifepristone to end a pregnancy, rarely the pregnancy may not end. It is very important for you to be closely monitored by your doctor and to keep your scheduled appointments to follow your progress. Be sure to have clear instructions from your doctor about who to call and what to do in case of an emergency. Expect vaginal bleeding after you take the combined medicine, however tell your doctor right away if you develop any unlikely symptoms such as severe/prolonged vaginal bleeding, signs of infection (including fever, chills), or fainting.
This drug must not be used during pregnancy to prevent stomach ulcers because of possible harm to an unborn baby (see also Warnings). If you are of childbearing age, use effective birth control methods while taking misoprostol and for at least one month or one completed menstrual cycle after you stop taking it. If you become pregnant or think you may be pregnant, inform your doctor right away.
This medication passes into breast milk. However, this drug is unlikely to harm a nursing infant. Consult your doctor before breast-feeding.
Interactions
See also the How to Use section.
Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval.
Does Cytotec interact with other drugs you are taking?
Enter your medication into the WebMD interaction checker
Overdose
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: severe drowsiness, seizures, severe dizziness, slow/irregular heartbeats.
Do not share this medication with others.
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.
Store at or below 77 degrees F (25 degrees C) in a dry place away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.
Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.
Images
Cytotec 200 mcg tablet
Color: whiteShape: hexagonalImprint: SEARLE 1461 a double stomach
This medicine is a white, hexagonal, scored, tablet imprinted with “SEARLE 1461” and “a double stomach”.
Cytotec 100 mcg tablet
Color: whiteShape: roundImprint: SEARLE 1451
This medicine is a white, hexagonal, scored, tablet imprinted with “SEARLE 1461” and “a double stomach”.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Cytotec Uses, Side Effects & Warnings
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Generic name: misoprostol [ mye-so-PRAH-stole ]
Drug class: Miscellaneous GI agents
Medically reviewed by Drugs.com on Nov 30, 2022. Written by Cerner Multum.
What is Cytotec?
Cytotec is used to prevent stomach ulcers during treatment with nonsteroidal anti-inflammatory drugs (NSAID) such as aspirin, ibuprofen, naproxen, celecoxib, diclofenac, indomethacin, meloxicam, and others.
Cytotec may also be used for purposes not listed in this medication guide.
Warnings
Cytotec can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage and dangerous uterine bleeding. Do not use this medicine if you are pregnant.
If you are able to become pregnant, you will need to have a negative pregnancy test before starting this treatment. You will also need to use effective birth control to prevent pregnancy during treatment.
Before taking this medicine
You should not use Cytotec if you are allergic to Cytotec or other prostaglandins, or if you are pregnant.
Tell your doctor if you have ever had:
May cause birth defects. Do not use if you are pregnant. You must use effective birth control while using Cytotec and for at least 1 month after your last dose. Tell your doctor if you become pregnant.
You will need to have a negative pregnancy test before starting this treatment.
Stop taking this medicine and tell your doctor right away if you become pregnant during treatment.
Ask a doctor if it is safe to breastfeed while using this medicine.
How should I take Cytotec?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Do not share this medicine with another person, even if they have the same symptoms you have.
Cytotec is usually taken four times a day with meals. The last dose of the day should be at bedtime. Follow your doctor’s instructions.
You may have nausea, stomach cramps, or diarrhea while taking this medicine, especially during the first few weeks after you start taking Cytotec. These symptoms usually last for about a week.
Call your doctor if you have severe nausea, stomach pain, or diarrhea lasting longer than 8 days.
Store at room temperature away from moisture and heat.
What happens if I miss a dose?
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Cytotec?
Follow your doctor’s instructions about any restrictions on food, beverages, or activity.
Cytotec side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Cytotec may cause serious side effects. Call your doctor at once if you have:
severe ongoing stomach discomfort or diarrhea; or
dehydration–dizziness, confusion, feeling very thirsty, less urination.
Common side effects of Cytotec may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Cytotec?
Tell your doctor about all your other medicines, especially:
antacids.
This list is not complete. Other drugs may affect Cytotec, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
More about Cytotec (misoprostol)
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Related treatment guides
- Duodenal Ulcer
- NSAID-Induced Ulcer Prophylaxis
- Stomach Ulcer
Further information
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medical Disclaimer
Copyright 1996-2023 Cerner Multum, Inc. Version: 10.01.
💊 Composition of Cytotec ✅ Use of Cytotec Save Search for analogues ⚠️ The state registration of this drug has been canceled Description of the active ingredients of the preparation Cytotec The scientific information provided is general and cannot be used to make decisions. Update date: 2020.05.01 Marketing authorization holder: SEARLE division of Monsanto, pls ATX code: A02BB01 (misoprostol) Active substance: Rec.INN registered by WHO Dosage form
Release form, packaging and composition |
K25 | Gastric ulcer |
K26 | Duodenal ulcer |
K27 | Peptic ulcer |
O04 | Medical abortion |
Y45 | Analgesics, antipyretics and anti-inflammatory drugs |
Dosage regimen
The method of administration and dosing regimen of a particular drug depends on its form of release and other factors. The optimal dosage regimen is determined by the doctor. Compliance of the dosage form of a particular drug with indications for use and dosing regimen should be strictly observed.
Taken orally. A single dose – 200-400 mcg, with hypersensitivity and renal failure – 100 mcg. The frequency of administration and duration of use depend on the indications and the effectiveness of treatment.
Side effects
From the digestive system: abdominal pain, flatulence, nausea, vomiting, diarrhea, constipation.
From the reproductive system: pain in the lower abdomen associated with contractions of the myometrium, dysmenorrhea, polymenorrhea, menorrhagia, metrorrhagia.
Allergic reactions: skin rash, itching, angioedema.
Other: change in body weight, asthenia, increased fatigue; extremely rarely – convulsions (in women in the pre- or postmenopausal period).
Contraindications for use
Severe liver dysfunction, inflammatory bowel disease, pregnancy, lactation, severe renal failure, enteritis, children and adolescents under 18 years of age, hypersensitivity to misoprostol.
Use during pregnancy and lactation
Use during pregnancy and lactation (breastfeeding) is contraindicated.
Be aware that misoprostol increases uterine tone and may cause miscarriage when used as a gastroprotective agent.
If use in women of childbearing potential is necessary, a serum pregnancy test should be performed and remain negative for 2 weeks prior to initiation of misoprostol therapy. Treatment can be started only on the 2-3rd day of normal menstruation. During the entire course of treatment, reliable methods of contraception should be used.
Use in hepatic impairment
Contraindicated in severe hepatic impairment.
Use in impaired renal function
Contraindicated in severe renal impairment.
Use in children
Contraindicated in children and adolescents under 18 years of age.
Special instructions
Use with caution in patients with arterial hypotension, ischemic heart disease, cerebrovascular accident, coronary cardiosclerosis, epilepsy, enterocolitis, diarrhea, hypersensitivity to prostaglandins or their analogues.
Use for termination of pregnancy is carried out only in combination with mifepristone and only in specialized medical institutions with appropriately trained medical personnel and with the ability to provide emergency surgical gynecological and blood transfusion care.
Acetylsalicylic acid and other NSAIDs should not be given for 1 week after taking misoprostol.
Drug interactions
Concomitant use with antacids reduces the concentration of misoprostol in blood plasma.
Simultaneous use with magnesium-containing antacids may increase diarrhea.
When used simultaneously with acenocoumarol, a case of a decrease in the anticoagulant effect of acenocoumarol has been described.
When used simultaneously with diclofenac, indomethacin, the side effects of diclofenac and indomethacin increase.
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Cytotec . Description of the drug in the reference book Vidal.
Cytotec :: Instructions :: Price :: Description of the drug Additive components: MCC, aerosil, sodium CMC, hypromellose, castor oil.
The active substance of Cytotec tablets is a synthesized analogue of prostaglandin E1 produced by the body. This molecule enhances the protective properties of the gastrointestinal mucosa by stimulating the production of mucus by the glandular cells of the stomach, enhancing the natural secretion of bicarbonate molecules.
It increases the resistance of the gastrointestinal mucosa, preventing aggressive components from food, alcoholic beverages, therapeutic drugs from harming the cells that form the gastrointestinal mucosa. Cytotec has the following effects:
– causes acid neutralization by enhancing the synthesis of bicarbonates;
– protects the walls of the stomach from aggressive molecules by increasing the production of mucus, improving its qualitative composition;
– improves blood supply to the gastrointestinal mucosa with stimulation of regenerative processes.
The misoprostol molecule reduces the production of pepsi molecules. The therapeutic effect starts 30 minutes after the use of the dosage form, lasts about 180 minutes. Misoprostol provokes contraction of the myometrium, increases the intensity of contractions.
Cytotec is prescribed for:
- the need to use NSAIDs;
- peptic ulcer of any localization;
- duodenal ulcer with or without bleeding;
- gastric ulcer with or without bleeding.
Cytotec tablet is taken by mouth. It is indicated to use the dosage form directly with food, after meals and before going to bed. For the treatment of ulcerative lesions of the gastrointestinal tract, gastritis with mucosal erosions, the daily dose is 0.8 mg divided into 2-4 doses.
In order to prevent the development of ulcerative lesions of the gastrointestinal tract, 0.4-0.8 mg / day is prescribed with a dose divided into 2-4 doses. If necessary, therapy with drugs of the NSAID group is indicated to take Cytotec during the entire treatment. During the period of exacerbation of duodenal ulcer, the drug should be taken for 1 month. A month later, endoscopy is done. If incomplete scarring is detected, the course is extended for another month.
The use of Cytotec tablets may be accompanied by:
- constipation;
- dysmenorrhea;
- diarrhea;
- skin rashes;
- pain in the lower abdomen;
- asthenia;
- gagging;
- headaches;
- hypermenorrhea;
- bloody vaginal discharge;
- bouts of nausea;
- change in body weight;
- convulsions;
- flatulence;
- epigastric pains.
Cytotec is not prescribed for:
- severe liver pathologies;
- arterial hypotension;
- acute renal failure;
- disorders of cerebral circulation;
- intestinal pathologies associated with inflammation;
- pregnancy;
- pregnancy planning;
- indications in premenopausal patients;
- indications in nursing;
- hypersensitivity to misoprostol;
- indications in patients under 17 years of age.
Caution is required when prescribing Cytotec tablets for:
- organic pathologies of cerebral vessels;
- acute peripheral circulatory disorders;
- epilepsy.
Cytotec tablets may cause self-abortion. The use of misoprostol-containing agents during pregnancy and suspected pregnancy is contraindicated.
Drug, drug group | Possible interaction result with misoprostol |
---|---|
Antacids | Significant reduction in the bioavailability of misoprostol |
Magnesium-containing antacids, aluminum-containing antacids | Occurrence or aggravation of diarrhea |
The use of the drug in dosages that exceed therapeutic may be accompanied by the following symptoms:
It is indicated to carry out the therapy corresponding to the appeared symptomatology.
Cytotec is available in tablet form. Packing: 50 tablets/package.
Storage temperature of Cytotec tablets is up to 30 degrees Celsius. The shelf life of the drug is 3 years.
Misoprostol, Mirolut, Misoprostol-HPMC, Cytotec.
See also Cytotec analogue list.
Misoprostol
A02BB01
Dose adjustment for geriatric patients is not required. For patients with diseases of the kidneys, liver and violation of their functions, standard dosing regimens are prescribed.
Pregnancy tests should be ordered for patients of childbearing age. Misoprostol is indicated to be administered a few days after the onset of normal menstruation. It is shown to use reliable contraceptive methods during therapy with Cytotec. This therapeutic agent can provoke an abortion due to a stimulating effect on the tone of the uterus.