Where are lymph nodes located in the body. How does the lymphatic system work. What causes lymph nodes to swell. How does cancer spread to lymph nodes. How is cancer in lymph nodes detected.

The Lymphatic System: A Crucial Component of Immune Defense

The lymphatic system plays a vital role in our body’s immune defense mechanism. It comprises a network of lymph vessels and nodes that work together to filter out harmful substances and maintain fluid balance. But how exactly does this complex system function?

The lymphatic system consists of:

• Lymph vessels
• Lymph nodes
• Lymph fluid
• White blood cells

Lymph vessels, similar to veins in the circulatory system, transport a clear, watery fluid called lymph throughout the body. This fluid contains white blood cells, which are crucial for fighting infections. The lymphatic system prevents fluid buildup and swelling by draining excess fluid from tissues and returning it to the bloodstream.

The Journey of Lymph Fluid

How does lymph fluid travel through the body? The process is quite fascinating:

1. Lymph vessels collect excess fluid from around cells
2. The fluid is directed towards the chest
3. It accumulates in a large vessel
4. Finally, it drains into a blood vessel near the heart

This continuous circulation ensures that our tissues remain healthy and free from excess fluid accumulation.

Lymph Nodes: The Body’s Natural Filtration System

Lymph nodes are small, bean-shaped structures scattered throughout the body. They act as filters, trapping foreign substances, including cancer cells and infectious agents. But where are these important structures located?

Lymph nodes can be found in various parts of the body, including:

• Neck
• Armpit
• Chest
• Abdomen
• Groin

Some lymph nodes are located deep inside the body, such as between the lungs or around the bowel. These nodes filter fluid in those specific areas, ensuring comprehensive coverage of the entire body.

The Filtering Process

How do lymph nodes filter out harmful substances? Each node contains immune cells that attack and destroy germs carried in the lymph fluid. As the fluid passes through these nodes, it’s cleansed of potential threats before continuing its journey through the body.

Swollen Lymph Nodes: A Sign of the Body’s Defense Mechanism

When lymph nodes swell, it’s often a sign that the body is fighting off an infection or dealing with an injury. This swelling, known as lymphadenopathy, occurs as the nodes work harder to filter out harmful cells. But what causes lymph nodes to swell?

Common causes of swollen lymph nodes include:

• Infections (e.g., ear infections, strep throat)
• Injuries
• Certain medications
• Immune system diseases
• Cancer (in some cases)

It’s important to note that swollen lymph nodes don’t always indicate a serious condition. In most cases, the swelling is localized to one area. However, when multiple areas of lymph nodes swell simultaneously (generalized lymphadenopathy), it may suggest a more systemic issue.

Cancer and the Lymphatic System: Understanding the Connection

The relationship between cancer and the lymphatic system is complex and multifaceted. Cancer can affect lymph nodes in two primary ways:

1. It can originate in the lymph nodes (lymphoma)
2. It can spread to the lymph nodes from another part of the body (metastasis)

Lymphoma, a cancer that starts in the lymphatic system, is less common than cancers that spread to the lymph nodes from other parts of the body. But how does this spread occur?

The Process of Cancer Metastasis to Lymph Nodes

Cancer cells can break away from the primary tumor and travel through the body via the bloodstream or lymphatic system. When they travel through the lymph system, these cells may end up in lymph nodes. The process of cancer spreading to a new part of the body is called metastasis.

For cancer cells to successfully metastasize, they must undergo several changes:

1. Break away from the original tumor
2. Attach to the outside wall of a lymph or blood vessel
3. Move through the vessel wall
4. Travel with the blood or lymph to a new organ or lymph node
5. Begin growing in the new location

It’s worth noting that most cancer cells that escape the primary tumor die before they can establish themselves elsewhere. However, even a small number of surviving cells can potentially form new tumors.

Detecting Cancer in Lymph Nodes: Challenges and Methods

Identifying cancer in lymph nodes can be challenging, especially in the early stages. Normal lymph nodes are typically small and difficult to detect. However, when affected by cancer, inflammation, or infection, these nodes can enlarge and become more noticeable.

How can cancer in lymph nodes be detected? Several methods are employed:

• Physical examination: Enlarged nodes near the body’s surface may be felt or even seen
• Imaging tests: CT scans, MRIs, or PET scans can reveal enlarged internal nodes
• Biopsy: A sample of the lymph node is examined under a microscope
• Sentinel lymph node biopsy: Used to determine if cancer has spread beyond the primary site

It’s important to note that not all enlarged lymph nodes contain cancer cells. A thorough examination and often a biopsy are necessary to confirm the presence of cancer.

The Impact of Lymph Node Removal in Cancer Treatment

In some cancer treatments, particularly for breast cancer and melanoma, lymph nodes may need to be removed. This procedure, known as lymph node dissection, can have various effects on the body. But what are the potential consequences of lymph node removal?

Possible effects of lymph node removal include:

• Lymphedema: Swelling due to lymph fluid buildup
• Increased risk of infection in the affected area
• Numbness or tingling sensation
• Limited range of motion in the affected limb

These effects can vary depending on the number of lymph nodes removed and the location of the surgery. Healthcare providers often recommend specific exercises and precautions to minimize these potential complications.

Advances in Lymph Node Cancer Research and Treatment

The field of lymph node cancer research is rapidly evolving, with new discoveries and treatment approaches emerging regularly. What are some of the latest developments in this area?

Recent advances include:

• Improved imaging techniques for more accurate detection of affected lymph nodes
• Targeted therapies that specifically attack cancer cells in lymph nodes
• Immunotherapy approaches that boost the body’s natural defenses against cancer
• Minimally invasive surgical techniques for lymph node removal
• Personalized treatment plans based on genetic profiling of tumors

These advancements are improving both the accuracy of diagnosis and the effectiveness of treatments for lymph node cancers and metastases.

The Promise of Immunotherapy

Immunotherapy has shown particular promise in treating lymph node cancers. By enhancing the body’s own immune response, these treatments can potentially target cancer cells more effectively while minimizing damage to healthy tissues.

Some immunotherapy approaches being studied include:

• Checkpoint inhibitors
• CAR T-cell therapy
• Cancer vaccines
• Monoclonal antibodies

While these treatments are still being refined, they offer hope for more effective and less toxic cancer therapies in the future.

Living with Lymph Node Cancer: Coping Strategies and Support

A diagnosis of lymph node cancer or metastasis can be overwhelming. However, there are numerous strategies and resources available to help patients cope with the physical and emotional challenges. How can individuals best navigate this difficult journey?

Effective coping strategies include:

• Seeking support from family, friends, and support groups
• Maintaining open communication with the healthcare team
• Engaging in stress-reduction techniques like meditation or yoga
• Staying physically active as much as possible
• Eating a nutritious diet to support overall health
• Considering counseling or therapy to address emotional concerns

It’s important to remember that everyone’s experience with cancer is unique. What works for one person may not be the best approach for another. Patients should work closely with their healthcare providers to develop a personalized coping strategy.

The Role of Palliative Care

Palliative care can play a crucial role in managing symptoms and improving quality of life for patients with lymph node cancer. This specialized medical care focuses on providing relief from the symptoms and stress of a serious illness.

Palliative care can help with:

• Pain management
• Emotional and psychological support
• Assistance with treatment decisions
• Coordination of care among different healthcare providers
• Support for family members and caregivers

Contrary to common misconceptions, palliative care is not just for end-of-life situations. It can be beneficial at any stage of illness, alongside curative treatments.

Prevention and Early Detection: Safeguarding Lymph Node Health

While not all lymph node cancers can be prevented, there are steps individuals can take to reduce their risk and catch potential issues early. What preventive measures can be taken to maintain lymph node health?

Preventive strategies include:

• Regular health check-ups and screenings
• Maintaining a healthy lifestyle (balanced diet, regular exercise, avoiding tobacco)
• Practicing good hygiene to prevent infections
• Being aware of family history and genetic risk factors
• Knowing the signs of swollen lymph nodes and when to seek medical attention

Early detection is crucial in improving outcomes for lymph node cancers. Individuals should be vigilant about any persistent swelling or lumps and consult a healthcare provider promptly if they notice any concerning changes.

Self-Examination Techniques

While not a substitute for professional medical care, self-examination can be a valuable tool in monitoring lymph node health. How can individuals effectively check their lymph nodes at home?

Steps for self-examination include:

1. Use fingertips to gently press along the sides of the neck, under the jaw, and behind the ears
2. Check the lymph nodes in the armpits
3. Feel for nodes in the groin area
4. Note any swelling, tenderness, or changes in size or texture

It’s important to become familiar with what’s normal for your body so that you can more easily detect any changes. Any persistent swelling or lumps should be evaluated by a healthcare professional.

The Future of Lymph Node Cancer Research: Emerging Trends and Possibilities

The landscape of lymph node cancer research is constantly evolving, with new discoveries and technologies paving the way for improved diagnosis and treatment. What are some of the most promising areas of research in this field?

Emerging trends in lymph node cancer research include:

• Liquid biopsies for non-invasive cancer detection
• Artificial intelligence for more accurate image analysis
• Nanotechnology for targeted drug delivery
• Gene editing techniques for personalized treatments
• Combination therapies that target multiple aspects of cancer growth

These innovative approaches hold the potential to revolutionize how we detect, treat, and manage lymph node cancers in the future.

The Promise of Precision Medicine

Precision medicine, which tailors treatment to the individual characteristics of each patient, is becoming increasingly important in lymph node cancer care. How might this approach change the landscape of cancer treatment?

Potential benefits of precision medicine include:

• More effective treatments with fewer side effects
• Better prediction of treatment outcomes
• Identification of patients most likely to benefit from specific therapies
• Development of new targeted therapies based on genetic profiles
• Improved quality of life for patients undergoing treatment

As our understanding of the genetic and molecular basis of cancer continues to grow, precision medicine approaches are likely to become increasingly refined and effective.

Global Perspectives on Lymph Node Cancer: Challenges and Opportunities

Lymph node cancer is a global health concern, but its impact and the resources available for diagnosis and treatment vary widely around the world. What are some of the key challenges and opportunities in addressing lymph node cancer on a global scale?

Global challenges include:

• Disparities in access to diagnostic tools and treatments
• Variations in cancer awareness and education across different cultures
• Limited resources for cancer research in many developing countries
• Differences in environmental and lifestyle risk factors across regions
• Barriers to implementing standardized treatment protocols globally

Despite these challenges, there are also significant opportunities for global collaboration in lymph node cancer research and care. International partnerships, telemedicine, and knowledge sharing initiatives are helping to bridge gaps and improve outcomes worldwide.

The Role of Global Health Organizations

International health organizations play a crucial role in addressing lymph node cancer on a global scale. How are these organizations contributing to the fight against cancer?

Key contributions include:

• Funding for research in underserved regions
• Development of global guidelines for cancer diagnosis and treatment
• Implementation of cancer awareness and prevention programs
• Coordination of international clinical trials
• Advocacy for policies that support cancer research and patient care

By fostering collaboration and sharing resources, these organizations are helping to reduce the global burden of lymph node cancer and improve outcomes for patients worldwide.

Lymph Nodes & Cancer | What are Lymph Nodes?

• What is the lymph system?
• Cancer in the lymph nodes
• Effects of removing lymph nodes

What is the lymph system?

The lymph (or lymphatic) system is a part of your body’s immune system. It includes a network of lymph vessels and lymph nodes. Lymph vessels are a lot like the veins that collect and carry blood through the body. But instead of carrying blood, these vessels carry the clear watery fluid called lymph. Lymph fluid also contains white blood cells, which help fight infections.

Lymph fluid would build up and cause swelling if it were not drained in some way. Lymph vessels draw up the lymph fluid from around the cells to send it towards the chest. There, lymph fluid collects into a large vessel that drains into a blood vessel near the heart.

Lymph nodes and what they do

Lymph vessels send lymph fluid through nodes throughout the body. Lymph nodes are small structures that work as filters for foreign substances, such as cancer cells and infections. They contain immune cells that can help fight infection by attacking and destroying germs that are carried in through the lymph fluid. Lymph nodes are located in many parts of the body, including the neck, armpit, chest, abdomen (belly), and groin. They contain immune cells that can help fight infection by attacking and destroying germs that are carried in through the lymph fluid.

There are hundreds of lymph nodes throughout the body. Each lymph node filters the fluid and substances picked up by the vessels that lead to it. Lymph fluid from the fingers, for instance, works its way toward the chest, joining fluid from the arm. This fluid may filter through lymph nodes at the elbow, or those under the arm. Fluid from the head, scalp, and face flows down through lymph nodes in the neck. Some lymph nodes are deep inside the body, such as between the lungs or around the bowel, to filter fluid in those areas.

Swollen lymph nodes

When there’s a problem, such as infection, injury, or cancer, lymph nodes in that area may swell or enlarge as they work to filter out the “bad” cells. Swollen lymph nodes (lymphadenopathy) tell you that something is not right, but other symptoms help pinpoint the problem. For instance, ear pain, fever, and enlarged lymph nodes near your ear are clues that you may have an ear infection or cold.

Some areas where lymph nodes commonly swell are in the neck, groin, and underarms. In most cases, only one area of nodes swells at a time. When more than one area of lymph nodes is swollen it’s called generalized lymphadenopathy. Some infections (such as strep throat and chicken pox), certain medicines, immune system diseases, and cancers like lymphoma and leukemia can cause this kind of swelling. Your health care provider will look for more information to figure out the cause of the swelling. Lymph node swelling is often caused by something other than cancer.

Cancer in the lymph nodes

Cancer can appear in the lymph nodes in 2 ways: it can either start there or it can spread there from somewhere else.

Cancer that starts in the lymph nodes is called lymphoma. You can read more about lymphoma in Hodgkin Lymphoma and Non-Hodgkin Lymphoma.

More often, cancer starts somewhere else and then spreads to lymph nodes. That is the focus of this section.

How does cancer spread to lymph nodes?

Cancer can spread from where it started (the primary site) to other parts of the body.

When cancer cells break away from a tumor, they can travel to other areas through either the bloodstream or the lymph system. If they travel through the lymph system, the cancer cells may end up in lymph nodes. Most of the escaped cancer cells die or are killed before they can start growing somewhere else. But one or two might settle in a new area, begin to grow, and form new tumors. This spread of cancer to a new part of the body is called metastasis.

In order for cancer cells to spread to new parts of the body, they have to go through several changes. They must become able to break away from the original tumor and attach to the outside wall of a lymph or blood vessel. Then they must move through the vessel wall to flow with the blood or lymph to a new organ or lymph node.

When cancer does spread to lymph nodes, it usually spreads to nodes near the tumor itself. These are the nodes that have been doing most of the work to filter out or kill the cancer cells.

How is cancer in lymph nodes found?

Normal lymph nodes are tiny and can be hard to find, but when there’s infection, inflammation, or cancer, the nodes can get larger. Those near the body’s surface often get big enough to feel with your fingers, and some can even be seen. But if there are only a few cancer cells in a lymph node, it may look and feel normal. Lymph nodes deep in the body cannot be felt or seen. So doctors may use scans or other imaging tests to look for enlarged nodes that are deep in the body. Often, enlarged lymph nodes near a cancer are assumed to contain cancer.

The only way to know whether there is cancer in a lymph node is to do a biopsy. Doctors may remove lymph nodes or take samples of one or more nodes using needles. The tissue that’s removed is looked at under the microscope by a pathologist (a doctor who diagnoses illness using tissue samples) to find out if there are cancer cells in it. The pathologist prepares a report, which details what was found. If a node has cancer in it, the report describes what it looks like and how much was seen.

When a surgeon operates to remove a primary cancer, they may remove one or more of the nearby (regional) lymph nodes as well. Removal of one lymph node is considered a biopsy, but when many lymph nodes are removed, it’s called lymph node dissection. When cancer has spread to lymph nodes, there’s a higher risk that the cancer might come back after surgery. This information helps the doctor decide whether more treatment, like chemo, immunotherapy, targeted therapy or radiation, might be needed after surgery.

What does it mean if there’s cancer in my lymph node?

If cancer is found in one or more lymph nodes, it could mean that more tests are needed to know how far the cancer has spread. This information is used to determine the stage of your cancer and the best treatment options.

For more information on staging, see Cancer Staging, or find your cancer type for more detailed information.

Effects of removing lymph nodes

When lymph nodes are removed, it can leave the affected area without a way to drain off the lymph fluid. Many of the lymph vessels now run into a dead end where the node used to be, and fluid can back up. This is called lymphedema, which can become a life-long problem. The more lymph nodes that are removed, the more likely it is to occur. To learn more about what to look for, ways reduce your risk, and how to manage this side effect, see Lymphedema.

Removing lymph nodes during cancer surgery is highly unlikely to weaken a person’s immune system, since the immune system is large and complex and is located throughout the body.

The American Cancer Society medical and editorial content team

Our team is made up of doctors and oncology certified nurses with deep knowledge of cancer care as well as journalists, editors, and translators with extensive experience in medical writing.

American Joint Committee on Cancer. AJCC Cancer Staging Manual, 8th ed. New York: Springer 2017: 715-725.

Liao S, von der Weid PY. Lymphatic system: an active pathway for immune protection. Semin Cell Dev Biol. 2015;38:83–89.

National Institute of Allergy and Infectious Diseases. Overview of the Immune System. Updated December 30, 2013. Accessed at https://www.niaid.nih.gov/research/immune-system-overview on February 23, 2021. 

Last Revised: March 2, 2021

American Cancer Society medical information is copyrighted material. For reprint requests, please see our Content Usage Policy.

Purpose, location, and disease warning signs

Lymph nodes are small, bean-shaped glands that play a crucial role in the immune system. They filter lymphatic fluid, which helps rid the body of germs and remove waste products. During an infection, a person may notice swollen lymph nodes, for instance, around the neck.

The body contains hundreds of lymph nodes. They form clusters around the body and are particularly prominent in areas such as the neck, armpit and groin and behind the ears.

The body’s cells and tissues dispose of waste products in lymphatic fluid, which lymph nodes then filter. During this process, they catch bacteria and viruses that could harm the rest of the body.

Lymph nodes are an essential part of the body’s immune system. Due to their function, they come into contact with toxins, which can cause them to swell. Although swollen lymph nodes are common, they may occasionally indicate lymph node cancer, or lymphoma.

Keep on reading to learn more about lymph nodes and their function within the immune system.

Lymph nodes are part of the lymphatic system, which is a complex network of nodes and vessels.

In certain areas of the body, such as the neck, armpit, and groin, lymph nodes sit close to the skin. This means a person may feel them swell when an infection develops.

Lymph nodes are also present in the stomach and between the lungs. However, there are no lymph nodes in the brain or spinal cord.

The name of a lymph node depends on its location in the body.

Lymph nodes form clusters throughout the body. Their main function is to filter out potentially harmful substances.

All tissues and cells in the body excrete lymphatic fluid, or lymph, in order to eliminate waste products. The lymph then travels through vessels in the lymphatic system and passes through lymph nodes for filtering.

Lymph nodes contain lymphocytes. These are a type of white blood cells that help destroy pathogens, such as bacteria, viruses, and fungi. When lymph nodes detect a pathogen in the lymph, they produce more lymphocytes, which causes them to swell.

Upon encountering bacteria or damaged cells, lymph nodes destroy them and turn them into a waste product.

When the lymph reenters the bloodstream, waste products travel to the kidneys and liver. The body then excretes waste products in the urine and feces.

Learn more about how the lymphatic system works here.

Swollen lymph nodes do not always indicate cancer. Below, we list some of many conditions that can cause lymph node swelling.

Lymphadenitis

Lymphadenitis occurs when bacteria, viruses, or fungi in the lymph infect lymph nodes. When this happens, lymph nodes swell and are painful to the touch.

If multiple clusters of nodes become infected, a person may feel pain and swelling in both their neck and groin.

The most common type of lymphadenitis is localized lymphadenitis. This means the condition only affects a few nodes. If the infection occurs in several node clusters, a doctor will likely diagnose generalized lymphadenitis.

The condition usually results from an infection elsewhere in the body.

Symptoms

Symptoms of lymphadenitis include:

• sore, swollen nodes
• soft or matted nodes
• skin streaking around the nodes
• abscesses around the nodes
• fluid seeping from the skin

Treatment

Lymphadenitis treatments include:

• antibiotics
• pain relief medication
• anti-inflammatories
• surgery

The type of treatment necessary will depend on a variety of factors, such as the severity of the disease and a person’s underlying conditions and allergies. A doctor will help a person choose the most suitable treatment based on these factors.

Learn more about swollen lymph nodes in the neck here.

Viral or bacterial throat infections

Swollen lymph nodes in the neck may be due to a viral or bacterial throat infection, such as strep throat.

Viral infections

Viral throat infections, such as colds, can present with swollen lymph nodes, a runny nose, and pinkeye.

These infections usually resolve on their own. However, a person can take over-the-counter pain relievers to alleviate pain they may experience when swallowing.

Strep throat

Strep throat is a bacterial infection that develops in the throat and tonsils due to group A streptococcus. People may contract strep throat if they come into contact with droplets containing the strep bacteria.

A person with strep throat may experience swollen lymph nodes on the neck, a sore throat, a fever, and red spots on the roof of the mouth.

Doctors treat strep throat with antibiotics.

Impetigo

Impetigo is an infection that develops due to group A streptococcus and may cause lymph nodes in the armpits and groin to swell.

A person can contract impetigo when the bacteria enter the body through a break in the skin. This can happen through sharing a towel, razor, or yoga mat.

Symptoms

Symptoms of impetigo include:

• itchy spots or sores around the nose or mouth that occur with change in skin color
• swollen lymph nodes
• painful sores
• blisters

Treatment

If a person has impetigo, they should seek medical attention to address their symptoms and prevent the condition from spreading to others.

Treatment will usually involve antibiotics.

Ringworm

Ringworm, or jock itch, is a fungal infection that can affect many areas of the body. If the fungus develops in the groin, a person may experience lymph node swelling in that area.

Typically, ringworm starts as a fungal lesion. The fungus often transmits when people share towels or razors.

Ringworm thrives in moist environments, and therefore a person should take care to dry thoroughly after a wash and try not to stay in damp clothes.

Symptoms

Common ringworm symptoms include:

• a patchy rash with a ring-like appearance and clear borders
• itchiness
• stinging
• flaky skin

Treatment

A doctor will prescribe an antifungal treatment to address ringworm.

The best way to prevent ringworm is to wear breathable fabrics, avoid sharing towels and razors, and dry thoroughly after bathing.

Learn more about swollen lymph nodes in the groin here.

Lymphoma is a type of cancer that affects the lymphatic system. The two main types of lymphoma are Hodgkin lymphoma and non-Hodgkin lymphoma.

Hodgkin lymphoma occurs when cancer cells spread from one cluster of lymph nodes to another. By contrast, in non-Hodgkin lymphoma, there is no order in how cancer cells spread throughout the lymphatic system.

Symptoms

Typical symptoms of lymphoma include:

• swollen lymph nodes
• fever
• night sweats
• fatigue
• unexplained weight loss

These are also common symptoms of viral infections, which can make lymphoma hard to diagnose. However, in people with lymphoma, symptoms tend to persist for longer periods of time.

It is of note that these symptoms do not clearly indicate cancer. If a person experiences any of these, they should contact a doctor to identify the cause of their symptoms.

Treatment

Treatment options for lymphoma include:

• CAR T cell therapy: This is a type of immunotherapy that uses a person’s own immune system to attack cancer cells.
• Chemotherapy: This therapy uses medication to destroy cancer cells.
• Radiation therapy: This treatment uses high energy beams to destroy cancer cells and shrink tumors.
• Stem cell transplant: A person receives stem cells from a donor. After they undergo high doses of chemotherapy, which destroys cancer cells and unhealthy blood cells, doctors implant stem cells, which start to produce new, healthy blood cells.

A person should contact a healthcare professional if they are experiencing persistent swelling of lymph nodes.

Swelling usually indicates an infection, and therefore a person should not immediately worry about lymphoma.

After reaching a diagnosis, a doctor will recommend the appropriate course of treatment.

Lymph nodes are a part of the lymphatic system. They filter lymph, which contains pathogens and damaged cells, and send the dead cells to the kidneys and liver.

Lymph node swelling usually results from an infection. In rare cases, however, it may be due to lymphoma.

If a person is concerned about swelling and other symptoms they have, they should contact a doctor.

What are lymph nodes and what to do if they are enlarged?

Lymph nodes allow lymph to pass through, retaining and destroying bacteria, viruses and malignant cells. Sometimes they increase, which raises many questions.

Let’s figure out what lymph nodes are, how they are arranged and why it is impossible to follow the advice from the Internet when they increase.

What are lymph nodes and why are they needed?

Lymph node is a peripheral organ of the immune system, located on the path of lymphatic vessels from organs and tissues.

Lymph is the liquid part of the blood that is filtered into the intercellular space through the walls of the capillaries. It is rich in proteins, electrolytes and water. It is impossible to lose these valuable substances, and it is impossible to return them back to the blood vessels through the wall. The “filtrate” of the blood enters the lymphatic system, from where it enters the superior vena cava through a network of vessels, that is, it returns to the bloodstream.

Along the course of the lymphatic vessels there are lymph nodes – rounded formations the size of a pea. At its core, a lymph node is an accumulation of protective cells – lymphocytes and macrophages – on a “frame” of connective tissue. Lymph nodes allow the flow of lymph through them, and the protective cells that make up them delay and destroy foreign agents (bacteria, parasites, viruses, tumor cells) that have entered the human body.

That is why the lymph nodes are called biological filters, and they themselves resemble knight’s castles, located in the most important directions of medieval states and protecting them from enemy attacks.

Classification of lymph nodes

There are approximately 500 lymph nodes in the human body. They are located mainly in groups. Each group receives lymph from a specific area of ​​the body or part of an organ. There are many classifications of lymph nodes, the simplest of them is a classification based on localization. There are no lymph nodes in the brain and spinal cord, bones, and the area of ​​the hands and feet.

Swollen lymph nodes: symptom or disease?

Swollen lymph nodes, or lymphadenopathy, is a symptom of a large number of diseases. This is not an independent disease, but only one of its signs, such as headache or fever.

Doctors have many classifications of lymphadenopathy. In this article, we will give only a couple of the main ones that will help in understanding the stated problem.

Depending on the extent of the process, lymph node enlargement can be local and generalized ¹ . In the first case, the lymph nodes of 1-2 adjacent anatomical regions increase. For example, submandibular and cervical. In the second case, there is an increase in lymph nodes in two or more non-adjacent, located far from each other, zones. For example, in the inguinal and axillary regions.

Duration of lymph node enlargement can be short (less than 2 months) and protracted (more than 2 months) ¹ .

Why do lymph nodes enlarge?

Swollen lymph nodes can be a symptom of both a relatively harmless disease and a very serious disease. Therefore, you need not to self-medicate, but to look for the cause. And this is the prerogative of the doctor.

Here are just some of the possible causes of swollen lymph nodes:

• infectious diseases . The entry of an infectious agent (virus, bacteria) into the lymph node leads to increased blood flow, active division of lymphocytes and enlargement of the lymph node. That is, this process is of a reciprocal protective nature. An increase in lymph nodes is observed with infections of the upper respiratory tract (adenoviral, tonsillitis), infectious mononucleosis, childhood infections (measles, rubella, mumps, chickenpox), cytomegalovirus infection, etc. In acute infectious diseases, an increase in lymph nodes is temporary and is accompanied by other symptoms (fever, general weakness, malaise, cough, runny nose). Also, swollen lymph nodes can be one of the symptoms of HIV infection;
• autoimmune connective tissue diseases . With these diseases, the human immune system does not work quite adequately, which is why the body begins to attack its own cells. An increase in lymph nodes can be observed with rheumatoid arthritis, systemic lupus erythematosus;
• pyoinflammatory processes of the skin, underlying structures and internal organs. Even panaritium or a bad tooth can cause an increase in lymph nodes;
• vaccination . The introduction of a killed pathogen or its parts into the body leads to the development of an immune response. An increase in lymph nodes is not at all uncommon;
• allergic reactions . Taking many medications (antibiotics, anti-inflammatory and lowering blood pressure) may be accompanied by an increase in lymph nodes;
• neoplastic diseases . Enlarged lymph nodes are a common and sometimes the only sign of cancer. In oncological diseases, it can be primary and secondary.

Primary enlargement of lymph nodes

It is observed in tumors that directly affect the lymphatic system – lymphomas. Usually in these cases, the lymph nodes are more than 2 cm in diameter, painless, and their increase occurs against the background of apparent health, which is why the person does not immediately turn to the doctor.

Secondary enlargement of lymph nodes

It is observed in a malignant neoplasm of any localization. For example, with breast cancer, the only sign may be an increase in the lymph nodes in the armpit.

The fact is that as soon as malignant cells find themselves in the intercellular space, they quickly enter the lymphatic capillaries, and from there to the nearest lymph node. There, some of them are destroyed, and some settle and begin to divide, forming a secondary tumor focus.

The division of tumor cells and the increase in the number of protective cells over time leads to an increase in the size of the lymph node. This is a kind of “price” for curbing the growth of a tumor and the spread of tumor cells throughout the body, because if there were no lymph nodes, tumor cells would very quickly enter the bloodstream and give distant metastases.

With local lymphadenopathy, the tumor is detected in about half of the cases, and with generalized lymphadenopathy – in almost 90% of cases ¹ ! Therefore, it is so important to exclude the tumor origin of lymphadenopathy and understand its causes. You should not waste precious time on self-treatment, and if enlarged lymph nodes appear, you should consult a doctor as soon as possible.

What should I do if my lymph nodes are enlarged and which doctor should I visit?

The adult needs to see a general practitioner and the child/teenager needs to be taken to see a pediatrician. Usually, a clinical examination and simple studies (general and biochemical blood tests, if necessary, X-ray examination or ultrasound of a certain area of ​​the body) are enough for a specialist to make a preliminary diagnosis and prescribe treatment or refer the patient to a narrower specialist (oncologist, surgeon, rheumatologist, infectious disease specialist) for further examination.

What not to do when the lymph nodes are “swollen”: breaking the stereotypes

Having discovered enlarged lymph nodes, many people, instead of going to the doctor and understanding the causes of what is happening, begin to self-medicate: heat the area of ​​the enlarged lymph node, drink antibiotics, use compresses, etc. You can find a great many similar tips on the Internet.

Should I do it? No way.

Warming up the area of ​​the lymph nodes

Many people use pan-calcined salt or a freshly boiled egg to warm up the area of ​​the enlarged lymph node. This is usually done to reduce pain. But for most patients, this is absolutely impossible. In the presence of an inflammatory process, thermal exposure will lead to vasodilation and increased inflammation, and in the case of a tumor process, it can accelerate cell division. Both will make the situation worse.

Taking antibiotics

There are many people who uncontrollably “treat” any “suspicious” symptoms with antibiotics. Of course, this is wrong. Antibacterial drugs are prescribed only by a doctor and strictly according to indications. In most cases, with an increase in lymph nodes, taking antibiotics is simply not advisable and will not give a positive effect.

Use of compresses, ointments/gels

The result here is the same as when warming up – the situation only gets worse. In addition, there is the danger of chemical burns to the skin.

Cabbage leaf application

Cabbage, of course, contains many vitamins and microelements, but it is completely useless as an anti-inflammatory agent. But before the patient has time to be convinced of this, some time passes – and the delay in treatment can have an extremely adverse effect on the result, especially when it comes to malignant diseases such as lymphomas.

Do not waste time on self-treatment! In most cases, this leads to a loss of time and aggravates the situation. Swollen lymph nodes may be a symptom of a serious illness. Consult a doctor who will understand the causes of enlarged lymph nodes and determine further management tactics.

M-EN-00005757 December 2021

Sources (Electronic resource). URL: https://diseases.medelement.com/disease/%D0%B4%D0%B8%D0%B0%D0%B3%D0%BD%D0%BE%D1%81%D1%82%D0%B8 %D0%BA%D0%B0-%D0%BB%D0%B8%D0%BC%D1%84%D0%B0%D0%B4%D0%B5%D0%BD%D0%BE%D0%BF% D0%B0%D1%82%D0%B8%D0%B9-%D0%BA%D1%80-%D1%80%D1%84-2018/16754 (Accessed 11/21/2021).

#Life with oncology#Cancer alertness#Useful information

where they are, what functions they perform, under what diseases they increase

Inflammation and enlargement of the lymph nodes usually cause discomfort and pain. As a rule, this indicates that an inflammatory process is underway in the body.

What are lymph nodes

Lymph nodes are the most important organs that perform a barrier-filtration function ¹ . Their main function is the biological filter of lymph – a colorless liquid that washes all the tissues and cells of the body. It consists of plasma and formed elements. Interestingly, the lymph plasma has an almost similar chemical structure to the blood plasma, but contains fewer proteins ² .

Useful information about lymph nodes

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Where are the lymph nodes

Lymph nodes are located almost everywhere. They are arranged in such a way as to become an obstacle in the way of various “garbage”: toxins, viruses, bacteria, parasites, fungi, cancer cells.

Most lymph nodes are located deep under the skin and even near internal organs where they cannot be felt. But some lymph nodes – under the jaw, in the armpits, in the groin – can be palpated even in a healthy, non-inflamed state.

Photo: Shutterstock

Functions of the lymph nodes

As mentioned earlier, the main function of the lymph nodes is barrier-protective function. In these organs of the lymphatic system, protective cells of the body are formed, such as lymphocytes, antibodies, phagocytes. Lymph nodes protect against the penetration of infections, and also prevent the reproduction of malignant tumor cells and play a role in the immune response to substances foreign to the body.

The lymph nodes also perform the following functions:

• hematopoietic – after the lymph nodes, lymph enriched with lymphocytes enters the blood;
• drainage – promote the outflow of excess fluid;
• depositing (reserve) – lymph node is a temporary storage of lymphocytes and lymph. The latter lingers in the lymph node in order to ensure the unloading of the bloodstream in “emergency” situations, for example, during venous congestion;
• metabolic – lymph nodes are involved in the metabolism of fats, proteins, carbohydrates and other substances.

Causes of swollen lymph nodes

Lymph nodes have their own diseases, and most often their inflammation is a reaction to some other disease or condition. Completely different reasons can lead to an increase in lymph nodes (lymphadenopathy). Consider the most common of them.

Local infections

Infection is one of the most common causes of swollen lymph nodes.

— For example, it can be acute respiratory diseases, leading to an increase in regional lymph nodes associated with the area in which the inflammation occurs, says doctor-therapist Oksana Khamitseva.

As a rule, the focus of the disease is located near enlarged lymph nodes. So, with infections of the upper respiratory tract, the lymph nodes in the neck become inflamed, with a sexual infection – in the groin.

Generalized viral and bacterial infections

If only one category of lymph nodes is affected, then they speak of local inflammation. If the nodes that are not adjacent to each other increase, then we are talking about a generalized inflammation of the lymph nodes.

This widespread inflammation can be caused by infections – bacterial, viral, fungal, which affect the entire body. It can be tuberculosis, some infectious skin diseases, rubella, chickenpox, cytomegalovirus, mononucleosis, HIV and others.

Autoimmune diseases

Autoimmune connective tissue diseases such as arthritis and systemic lupus erythematosus can also cause swollen lymph nodes. In such diseases, the body begins to attack its own cells. Due to the increasing load on the lymph nodes, their inflammation occurs.

Tumor processes

Swollen lymph nodes can also signal tumor processes in the body. As we wrote above, lymph nodes prevent the reproduction of cancer cells, but in some cases, tumor cells can get stuck in them and multiply. Tumor processes can lead to the development of leukemia, lymphogranulomatosis, lymphoma.

Hypersensitivity of the body

Allergic reactions can also provoke inflammation of the lymph nodes. In addition, their increase may be associated with hypersensitivity to certain drugs.

How lymph nodes are treated

The treatment of lymphadenopathy is varied and always depends on its cause. An increase in lymph nodes is a signal of inflammation, so you need to look for its source.

Most often, inflammation of the lymph nodes occurs as a secondary process, that is, a reaction to another disease:

• if this is associated with acute respiratory infections, then it is necessary to treat the respiratory tract infection itself, be it a bacterium or a virus;
• if it is associated with a generalized infection (mononucleosis, HIV), then long-term specific therapy is selected here;
• cat-scratch disease (felinosis) is treated with special antibiotics;
• Sepsis is stopped only in the hospital by intravenous administration of various drugs, including antibiotics, and ionic solutions.
• autoimmune diseases (systemic lupus erythematosus, Kawasaki disease, etc.) are treated by a rheumatologist, prescribing hormones or cytostatics in long courses under constant supervision.

Lymphadenopathy can also be caused by cancer. Conventionally, they can be divided into 3 sections:

1. leukemia, when the primary malignant focus is in the bone marrow;
2. lymphomas, when the foci are located directly in the lymph nodes;
3. metastases, when the focus is located in the internal organ, and cancer cells affect the lymph nodes in the path of lymph outflow.

— In the case of leukemia, bone marrow transplantation is possible. With lymphoma, it is useless to do this, you can only use various options for radiation, chemotherapy, genetic engineering methods. And if lymphadenopathy is caused by metastases, then, as a rule, the tumor of the corresponding organ is removed, entering healthy tissues and capturing the “package” of affected lymph nodes, says our expert Oksana Khamitseva.

How to maintain the health of the lymphatic system at home

According to physician Oksana Khamitseva, the health of the lymphatic system primarily depends on two components: good lymphatic drainage and normal functioning of the immune system. This is not difficult to achieve:

• regular physical activity;
• avoid tight, constricting clothing;
• smoking and alcohol cessation;
• courses of multivitamins 2 times a year;
• food high in protein and fiber in the diet;
• adequate fluid intake.

Popular questions and answers

General practitioner Oksana Khamitseva answers popular questions about lymph nodes.

Which lymph node is responsible for what?

– Each internal organ is supplied with lymph nodes, arteries and veins. If we talk about those lymph nodes that we can feel:

• Submandibular: increase with rhinitis, pharyngitis, tonsillitis, inflammation of the teeth and gums.
• Cervical: inflamed with acute respiratory infections, conjunctivitis, otitis media.
• Parotid: react to otitis media, acute respiratory infections.
• Occipital: increased with head and neck infections, acute tonsillitis, infectious mononucleosis.
• Axillary: may also be associated with mononucleosis, mastitis, breast cancer, HIV, cat scratch disease.
• Elbows: felinosis, HIV.
• Inguinal: mumps, generalized infections, inflammation of the urogenital organs.

What to do if the lymph nodes are inflamed?

— If you have lymphadenitis, you need to see a doctor, because you don’t know what it can be connected with. If you notice an increase in lymph nodes in the head and neck, there are signs of acute respiratory infections (runny nose, sore throat, cough, fever), then you can independently start taking vitamins, antiviral drugs, NSAIDs, symptomatic treatments for colds.

If you notice an increase in lymph nodes, which is objectively not related to the infectious process, then doing something without a doctor’s recommendation can be dangerous. Even taking vitamins, if the process is autoimmune, will spur the immune system to even more aggressive inflammation.

Why is inflammation of the lymph nodes dangerous?

— Complications of lymphadenitis include:

• transfer of infection to nearby tissues: bones, subcutaneous fat, skin;
• blockage by blood clots of veins adjacent to inflamed lymph nodes;
• violation of lymphatic drainage, edema, “elephantiasis” of the limbs.

What can not be done with enlarged lymph nodes?

– If you notice an increase in lymph nodes, then it is strongly not recommended to ignore it, heat or apply ice, make lotions without the permission of a doctor. Also, do not smear with anti-inflammatory ointments (you will reduce one lymph node and decide that you are cured, and if it is an oncology?), squeeze and massage the lymph node.

The patient does not know in which direction the lymph flows from this or that lymph node, and if you make the wrong movements, stagnation can be provoked.

Which doctor treats lymph nodes?

— All roads lead to a therapist. After examination and examination, a specialist can identify what lymphadenitis is associated with, treat acute respiratory infections or refer to an ENT doctor, an infectious disease specialist if an infectious process is detected. If an autoimmune disease is detected, your doctor is a rheumatologist, and in case of suspicion of leukemia or lymphoma, an oncologist.

Sources:

1. Semioshko N.V. Lymph nodes adjacent to the celiac trunk // BBC 28.706 Ya431 V 38. – 2014. – P. 111. http://sno.grsmu.by/conference/mk47.pdf#page=111
2. Pogrelchuk O.E., Danko E.S. Blood and lymph. Hematopoiesis // In the world of scientific discoveries. – 2018. – S. 219-221. https://www.elibrary.ru/download/elibrary_36443065_39723184.pdf
3. Dvoretsky L.I. Differential diagnosis in lymphadenopathy // Handbook of a polyclinic doctor. – 2005. – no. 2.