What Is Promethazine? | Promethazine Effects & Abuse

Reviewed by: Sophie Stein, MSN

Updated: Apr 19, 2023

Promethazine is a prescription antihistamine with a known potential for abuse, especially when combined with substances like codeine or alcohol. Read on to learn more about promethazine side effects, the dangers of promethazine misuse, and how to get help if you or someone you know has developed a promethazine addiction.

What Is Promethazine?

Promethazine is a prescription medication developed in the mid-1940s, when a team of scientists from the French chemical manufacturing company Rhône-Poulenc combined phenothiazine and a diamine side chain of diphenhydramine to create a new drug. Their creation, promethazine, is a synthetic medication that belongs to a pharmaceutical family known as phenothiazines.

More recently, promethazine has gained a reputation as a potential drug of abuse, popularized in rap songs and on social media as an ingredient in what’s sometimes called “purple drank,” “sizzurp,” or “lane. ”

What Is Promethazine Used For?

As a medication, promethazine has several uses, including the treatment of allergies, motion sickness, and more. It is also a strong sedative sometimes prescribed during labor, before and after surgery, and at other times.

Promethazine is a first-generation antihistamine only available by prescription. It effectively treats several conditions, such as:

• Allergies.
• Motion sickness.
• Nausea/vomiting.
• Hives.

Promethazine may also be used with other medicines to treat symptoms of the common cold, including sneezing, cough, and runny nose.

Promethazine Side Effects

Even though promethazine is a useful medicine, it is not without risks. Common side effects of promethazine include:

• Drowsiness.
• Blurred vision.
• Sedation.
• Confusion.
• Dizziness.

Rare but serious side effects of promethazine include:

• Respiratory depression.
• Seizures.
• Hallucinations.
• Changes in heart rate.
• Yellow skin and/or eyes.
• Fever.
• Rigid muscles.

Is Promethazine Abused?

Yes, although it is not a controlled substance, promethazine does have the potential to be abused. Research has drawn links between promethazine misuse and people with a history of opioid addiction or other substance use disorders.

Promethazine misuse may also be more common among adolescents, due to the spread of popular music and social media content glamorizing the use of promethazine in concoctions like purple drank.

While it is clear that promethazine abuse can be dangerous, there is not much research that offers a clear picture of its addictive potential.

Promethazine Mixed With Other Substances

The risk of misuse and addiction heightens when promethazine is combined with codeine and other addictive substances like alcohol. A formulation of promethazine mixed with codeine was previously available in the U. S. as a prescription cough and cold medicine.

Although the prescription version of promethazine with codeine has since been discontinued—due to rising misuse—the drug is still being found on the black market and purchased illicitly.

Codeine is a type of prescription opioid that can alleviate coughing and pain. However, all opioids are federally controlled substances with a known potential for misuse, addiction, and overdose.

Additionally, both codeine and promethazine can have sedative effects and cause respiratory depression (i.e., slowed or stopped breathing). Mixing promethazine with codeine or any other sedatives (e.g., alcohol or benzodiazepines like Xanax) is very dangerous.

Promethazine Abuse & Overdose

Promethazine abuse can lead to side effects that range from inconvenient and uncomfortable to incredibly dangerous and life-threatening. Overdosing on promethazine may cause symptoms such as:

• Trouble breathing.
• Decreased or stopped breathing.
• Dizziness/fainting.
• Increased heart rate.
• Tense muscles.
• Incoordination.
• Dilated pupils.
• Flushing.
• Excessive agitation or excitement.
• Lost of consciousness.

Promethazine Withdrawal Symptoms

People who frequently use codeine (with or without promethazine) may develop a dependence on opioids. If they stop using it or drastically decrease their use, they may experience withdrawal. Withdrawal can be very uncomfortable and last several days, with symptoms that may include:

• Dilated pupils.
• Sweating.
• Runny nose.
• Restlessness/irritability/anxiety.
• Trouble sleeping.
• Increased heart rate.
• Increased breathing rate.
• Chills.
• Nausea/vomiting.
• Stomach cramps.
• Diarrhea.
• Muscle aches.

Treatment for Promethazine Addiction

If you or a loved one is struggling with an addiction to cough syrup or cold medicine, it is important to get treatment as soon as possible. At our inpatient drug rehab in Orange County, we provide whole-person, addiction-focused healthcare to help you find meaningful recovery from substance use disorders. We offer different types of addiction treatment, including inpatient residential treatment and medical detox.

For more information about our facility and programs, such as how to start addiction treatment or what to expect in inpatient rehab, please contact our caring admissions navigators at . They can also answer your questions about using your insurance to pay for rehab or other rehab payment options.

You aren’t alone. You deserve to get help.

We are here to help you get sober and learn how to stay that way. Laguna Treatment Hospital is located in Orange County within easy reach of the entire Los Angeles metro. We are the premier chemical dependency recovery hospital in the OC. We offer safe medical detox, mental health support, and wellness programs.

What Is Promethazine? | Promethazine Effects & Abuse

Reviewed by: Sophie Stein, MSN

Updated: Apr 19, 2023

Promethazine is a prescription antihistamine with a known potential for abuse, especially when combined with substances like codeine or alcohol. Read on to learn more about promethazine side effects, the dangers of promethazine misuse, and how to get help if you or someone you know has developed a promethazine addiction.

What Is Promethazine?

Promethazine is a prescription medication developed in the mid-1940s, when a team of scientists from the French chemical manufacturing company Rhône-Poulenc combined phenothiazine and a diamine side chain of diphenhydramine to create a new drug. Their creation, promethazine, is a synthetic medication that belongs to a pharmaceutical family known as phenothiazines.

More recently, promethazine has gained a reputation as a potential drug of abuse, popularized in rap songs and on social media as an ingredient in what’s sometimes called “purple drank,” “sizzurp,” or “lane.”

What Is Promethazine Used For?

As a medication, promethazine has several uses, including the treatment of allergies, motion sickness, and more. It is also a strong sedative sometimes prescribed during labor, before and after surgery, and at other times.

Promethazine is a first-generation antihistamine only available by prescription. It effectively treats several conditions, such as:

• Allergies.
• Motion sickness.
• Nausea/vomiting.
• Hives.

Promethazine may also be used with other medicines to treat symptoms of the common cold, including sneezing, cough, and runny nose.

Promethazine Side Effects

Even though promethazine is a useful medicine, it is not without risks. Common side effects of promethazine include:

• Drowsiness.
• Blurred vision.
• Sedation.
• Confusion.
• Dizziness.

Rare but serious side effects of promethazine include:

• Respiratory depression.
• Seizures.
• Hallucinations.
• Changes in heart rate.
• Yellow skin and/or eyes.
• Fever.
• Rigid muscles.

Is Promethazine Abused?

Yes, although it is not a controlled substance, promethazine does have the potential to be abused. Research has drawn links between promethazine misuse and people with a history of opioid addiction or other substance use disorders.

Promethazine misuse may also be more common among adolescents, due to the spread of popular music and social media content glamorizing the use of promethazine in concoctions like purple drank.

While it is clear that promethazine abuse can be dangerous, there is not much research that offers a clear picture of its addictive potential.

Promethazine Mixed With Other Substances

The risk of misuse and addiction heightens when promethazine is combined with codeine and other addictive substances like alcohol. A formulation of promethazine mixed with codeine was previously available in the U.S. as a prescription cough and cold medicine.

Although the prescription version of promethazine with codeine has since been discontinued—due to rising misuse—the drug is still being found on the black market and purchased illicitly.

Codeine is a type of prescription opioid that can alleviate coughing and pain. However, all opioids are federally controlled substances with a known potential for misuse, addiction, and overdose.

Additionally, both codeine and promethazine can have sedative effects and cause respiratory depression (i.e., slowed or stopped breathing). Mixing promethazine with codeine or any other sedatives (e.g., alcohol or benzodiazepines like Xanax) is very dangerous.

Promethazine Abuse & Overdose

Promethazine abuse can lead to side effects that range from inconvenient and uncomfortable to incredibly dangerous and life-threatening. Overdosing on promethazine may cause symptoms such as:

• Trouble breathing.
• Decreased or stopped breathing.
• Dizziness/fainting.
• Increased heart rate.
• Tense muscles.
• Incoordination.
• Dilated pupils.
• Flushing.
• Excessive agitation or excitement.
• Lost of consciousness.

Promethazine Withdrawal Symptoms

People who frequently use codeine (with or without promethazine) may develop a dependence on opioids. If they stop using it or drastically decrease their use, they may experience withdrawal. Withdrawal can be very uncomfortable and last several days, with symptoms that may include:

• Dilated pupils.
• Sweating.
• Runny nose.
• Restlessness/irritability/anxiety.
• Trouble sleeping.
• Increased heart rate.
• Increased breathing rate.
• Chills.
• Nausea/vomiting.
• Stomach cramps.
• Diarrhea.
• Muscle aches.

Treatment for Promethazine Addiction

If you or a loved one is struggling with an addiction to cough syrup or cold medicine, it is important to get treatment as soon as possible. At our inpatient drug rehab in Orange County, we provide whole-person, addiction-focused healthcare to help you find meaningful recovery from substance use disorders. We offer different types of addiction treatment, including inpatient residential treatment and medical detox.

For more information about our facility and programs, such as how to start addiction treatment or what to expect in inpatient rehab, please contact our caring admissions navigators at . They can also answer your questions about using your insurance to pay for rehab or other rehab payment options.

You aren’t alone. You deserve to get help.

We are here to help you get sober and learn how to stay that way. Laguna Treatment Hospital is located in Orange County within easy reach of the entire Los Angeles metro. We are the premier chemical dependency recovery hospital in the OC. We offer safe medical detox, mental health support, and wellness programs.

The action of the drink “Lin” from codeine and sprite

Pharmacy drug addiction has received an impetus to development in our country in the 70s of the last century. Cheap pills and syrups replaced expensive illegal drugs. Drug addicts used completely legal pharmaceutical preparations as precursors (the basis for creating a drug). Among the common drugs that came out of pharmacies, Lin can be distinguished.

What is a leen, lin drink?

Lin – what is it? A lean or leen drink is a purple narcotic cocktail that came to us from abroad. The classic composition is based on codeine and sprite. What is codeine? This is the basis for the creation of painkillers and antitussive drugs. Among the drugs that were previously distributed without a doctor’s prescription, one can single out the well-known Codelac (cough remedy), Nurofen, Pentalgin, Sedalgin-Neo, etc. All of them contain on average 8mg/tab. The active ingredient is codeine.

Sprite and cough syrup (lean with codeine syrup) – this is the basis of the drug cocktail, which is a frequenter of nightclubs and parties. Quite often, in order to enhance the narcotic effect, the creators mix lin and alcohol. In this case, the human body receives a double blow of toxins, which threatens with dangerous health consequences.

Origin of Lean

How was Lean created? The idea to combine a popular carbonated drink with a pharmacy drug came up with the American DJ Skru (DJ Screw), known among hip-hop fans. The cocktail stood out quite strongly from the rest both in color and in effect, so it quickly attracted the attention of young people and spread to nightclubs. A feature of the mixture of codeine syrup with sprite is a bright, rich, attractive color. It was he who became the hallmark of a narcotic cocktail.

The lin drink has a relaxing effect, as it affects the human nervous system. It was this effect of codeine syrup with sprite that caught the attention of DJ Screw. Under the influence of this narcotic substance, the DJ created a new direction in the world of music. A distinctive feature of the musical genre was slow-motion inserts, under which you could relax, relieve stress and get the maximum enjoyment from the drink. Hip-hop rhythms combined with viscous compositions only contributed to the spread of the cocktail, which later led to the emergence of a whole subculture.

It is important to understand that lean is not a drug. Despite the fact that medications are in the composition of the drink, it carries great harm to the body. Later in the article, you will learn what dangers are fraught with a common drink based on sprite and codeine cough syrup.

Other names and legal analogues

The narcotic cocktail has a lot of names and analogues, which differ both in appearance and composition. Among them:

• Sizzrp;
• Purp, erp;
• dirty sprite;
• shingle;
• Purple drank.

In many names, the basis “purple” is clearly traced, which means “purple” in English.

Today it is impossible to buy or make your own Lean drink. First of all, because in our country all codeine-containing drugs and syrups are dispensed from pharmacies only by prescription. However, despite the fight against illegal trade, drugs seep into the hands of drug addicts illegally. In the wake of the popular cocktail and its ban, in 2008 foreign companies created legal analogues of the drink, which did not contain narcotic substances at all, and soothing herbs were the basis of their composition. However, Drank was similar to the original only in color, so it did not find a response among young people and ceased to exist. However, the manufacturers did not stop there and soon released a drink called Lean, which, by the way, had a similar success.

Dirty sprite – what is it?

This is how purple cough syrup began to be called in our country, which interferes with sprite. In fact, this is a complete analogue of Lin, which was created to lift the mood and relax the effect. Beer and vodka have been replaced in many clubs by drug cocktails, which were created not only from safe ingredients, but also mixed with harder drugs, synthetic cannabinoids and spirits to enhance the effect.

What is codeine syrup?

Codeine syrup or codeine syrup – what is it? This is the basis of the notorious cocktail, which is a cough medicine. Among them are Kofeks, Codelac Neo and Fito, Tussamag, Neo-kodin, Codesan, Kodarin, Terpinkod. In some cases, pharmacy addicts use painkillers such as Pentalgin, Caffetin as euphoretics.

What is a codeine cocktail? It’s a combination of cough syrup and sprite. In this case, a harmless cough medicine (syrup) acts as a drug. It is impossible to say one hundred percent that the syrup is narcotic, since when used in therapeutic doses according to a doctor’s prescription, it is not dangerous and causes drug dependence. Habituation can only be caused by regular abuse in large doses for recreational purposes.

Purple Drunk (drink) – what is it?

Purple drink or Purple drink is the same purple club drug that is common abroad in the form of a purple drink. At one time, he became an integral part of the Hip-Hop movement, which was distributed throughout America. Sprite and codeine are still the same Lean, while Mountain Dew could have been the basis.

Ingredients of Lean and Purple drunk

What is the composition of the popular drink, and can it be made at home? How to make a purple drink or lean drink? To prepare a cocktail, codeine and promethazine are used. However, if earlier it was not difficult to create a narcotic drink Lin, today it is impossible to get codeine syrup without a doctor’s prescription.

Where can I get a prescription for codeine syrup?

Codeine-based drugs were banned from being sold without a prescription in 2012. However, drug addicts always find ways to get what they want, often they steal from pharmacies or try to fake a doctor’s prescription.

In addition to the base and carbonated drink, there is often a sweet candy in the composition. The created drink carries a huge health hazard. It gives a person an unforgettable and unusual euphoric effect, which is very quickly addictive. The addict drinks glass after glass without realizing the danger. And the danger, at least, is that various components that a person does not even know about can be added to the composition of the Lean and Purple drunk drink. This is both alcohol and other drugs.

Promethazine with codeine

Promethazine with codeine syrup – this is the inscription on the label of dangerous syrups containing codeine and promethazine. Promethazine (an antihistamine) is a phenothiazine derivative that looks like a white crystalline powder. The substance is perfectly soluble in water and alcohol, due to which it was these syrups that were used to create the drink perp.

Promethazine and codeine syrup

In combination with codeine, it gives a mild euphoric effect. The weak opiate effect is explained by the fact that codeine is an opium alkaloid and belongs to opioid drugs along with heroin and methadone. However, if heroin addicts inject the mixture intravenously, codeine addicts have found an easier way to consume. What is the effect of codeine syrup? Read further in the article.

How does Lean affect the human body?

Codeine causes a trip almost immediately after use. As soon as a person drinks a cocktail, he begins to feel its narcotic effect. Codeine is a euphoretic. Therefore, the effect of codeine syrup is euphoric. A person is immersed in a feeling of calmness, peace and relaxation. The drug allows him to forget about all the problems and complexes, cheers up.

The pleasure from the Lean drink is quite strong, a person longs to use another cocktail again and again, but do not forget that it contains a medical preparation that has its own therapeutic doses. The main danger of regular use is an overdose. A person can no longer refuse the next dose of the substance, a persistent psychological dependence is formed.

With regular use, addiction occurs, both psychological and physiological, which leads to serious consequences for the organism of the addict. Each medicine has not only a permitted dosage, but also a number of contraindications that a person who is addicted to cocktails does not think about.

Being at a party or in a club, a person does not notice how he drinks glass after glass, he wants to prolong the pleasure, but rather soon the effect of the narcotic cocktail subsides, side effects of use appear: clouding of consciousness, poisoning and overdose. A person’s condition worsens, he feels sick, dizzy, gastrointestinal disorders occur. In case of poisoning or overdose, it is necessary to urgently seek help. Emergency narcological assistance is provided by specialists of the Healthy Krasnodar drug addiction treatment clinic. Call our toll-free hotline to call a doctor or get advice on chemical dependency issues. You will be answered within 2 minutes and will have a detailed consultation, as well as come to the rescue to eliminate drug intoxication.

Codeine and Sprite – effects on the body and consequences of use

Naturally, the combination of soda and pharmacy drugs has negative consequences for the addict’s body. With regular systematic use of Lin based on codeine, a person develops a number of pathologies. These are, first of all, diseases of the cardiovascular system, as well as the central nervous system. Euphoretic has a very negative effect on the central nervous system of a person, which leads to a violation of cognitive functions, thinking, logic, intelligence, memory, etc.

Codeine drinks destroy internal organs, disrupt the functioning of the gastrointestinal tract, contribute to the development and exacerbation of a number of life-threatening diseases. Already after the first use, the drug begins to destroy the human body, it has depression of the respiratory center, which can lead to suffocation and death during subsequent doses.

Side effects and overdose

With regular use of lin and purple shingles, the risk of overdose is quite high. The addict ceases to control the amount of alcohol consumed, which provokes the development of severe intoxication. Among the symptoms of an overdose, suffocation, pallor of the skin, increased respiration, weakness, loss of strength can be distinguished. Pleasant sensations are replaced by fatigue, decreased performance, hand tremors. The addict’s heart rate decreases, blood pressure drops, limbs tremble. In case of an overdose, a person may faint. If you lose consciousness, you should immediately consult a doctor. You can call emergency drug treatment in Krasnodar by phone: 8 (800) 770-00-95.

A lethal outcome from purple or lin is not a fairy tale, but a fact proven by narcologists. An unusual drug in the form of a drink attracts attention and makes you want to try it. A person feels pleasant sensations and does not want them to end. It is at this point that the addiction trap closes. A person with addiction cannot stop using codeine-containing drugs and drinks based on syrup and codeine on his own. Quite often, an overdose of codeine and promethazine becomes fatal if help is not called in time.

Fun fact: Lean’s creator, DJ Skru, died from his own invention in 2000.

How to deal with addiction?

It is important to understand that there are many cases in history that an overdose from purple shingles is possible even after drinking just one glass. Quite after one evening spent with cocktails, a person has severe intoxication. How to get rid of drug addiction? How to quit using drugs?

Doctors of the Healthy Krasnodar Narcological Rehabilitation Center can help an addict cope with addiction to codeine. This is a comprehensive treatment for drug addiction.

1. Complete cleansing of the body and elimination of toxins. The procedures are carried out with the use of drugs that accelerate the metabolism and withdrawal of drugs. If the condition of the addict is severe, help is required urgently, droppers are installed, medicines are infused intravenously.
2. Elimination of physical dependence. The drugs help restore the addict’s body and normalize the functions of internal organs, eliminating the consequences of codeine addiction.
3. Rehabilitation. It is the psychological craving for euphoria and narcotic high that does not allow a person to give up this or that drug. It arises due to subconscious problems that the addict will have to deal with together with the doctors of the Healthy Krasnodar center in individual and group sessions. A course of psychosocial rehabilitation gives a person guarantees for recovery.

Treatment of dependence on codeine and codeine-containing drugs, as well as drugs created on their basis, is carried out by experienced specialists using modern medicines and equipment. If you or your loved one has an addiction, don’t put off solving the problem until tomorrow, seek drug treatment today!

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