Colesevelam interactions. Colesevelam: Mechanism, Indications, and Interactions – A Comprehensive Guide

23.08.202317.07.2023 by alexxlab

How does colesevelam work to lower cholesterol. What are the approved indications for colesevelam. What are the potential side effects and drug interactions of colesevelam. How should colesevelam be administered for optimal effectiveness.

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Understanding Colesevelam: A Novel Antihyperlipidemic Drug

Colesevelam is an FDA-approved antihyperlipidemic medication that belongs to the class of drugs known as bile acid sequestrants. It is primarily used to lower elevated low-density lipoprotein cholesterol (LDL-C) levels in patients with primary hyperlipidemia and other conditions causing hyperlipidemia. Additionally, colesevelam has shown efficacy in improving glycemic control in adults with type 2 diabetes mellitus.

Key Indications for Colesevelam Use

Primary hyperlipidemia treatment
Lowering LDL-C in heterozygous familial hypercholesterolemia
Glycemic control in type 2 diabetes mellitus
Potential off-label use for irritable bowel syndrome with diarrhea

Can colesevelam be used as monotherapy? Yes, colesevelam can be used as monotherapy or in combination with other lipid-lowering agents such as statins, ezetimibe, or niacin. The flexibility in its usage allows healthcare providers to tailor treatment plans to individual patient needs.

Mechanism of Action: How Colesevelam Lowers Cholesterol

Colesevelam’s primary mechanism of action involves the formation of nonabsorbable complexes with bile acids in the gastrointestinal tract. This process is facilitated by the drug’s numerous hydrophobic side chains, which enhance its ability to bind bile acids.

The Cholesterol-Lowering Process

Colesevelam binds to bile acids in the GI tract
Bound bile acids are prevented from being reabsorbed
Reduction in total bile acid pool triggers upregulation of 7-alpha-hydroxylase enzyme
Increased conversion of intracellular cholesterol to bile acids
Upregulation of hepatic LDL receptors to meet cholesterol demand
Overall decrease in plasma LDL and total cholesterol levels

How does colesevelam affect glucose levels? While the exact mechanism is not fully understood, animal studies suggest that colesevelam may increase glucagon-like peptide-1 (GLP-1) and other incretins. This action appears to suppress hepatic glycogenolysis, potentially leading to reduced serum glucose levels in type 2 diabetic patients.

Administration and Formulations of Colesevelam

Colesevelam is available in multiple formulations to accommodate patient preferences and needs. The proper administration of colesevelam is crucial for its effectiveness and to minimize potential interactions with other medications or nutrients.

Available Formulations

Oral tablets
Prepared suspension
Chewable bar (recently approved)

What is the recommended dosing schedule for colesevelam? The medication is typically taken once or twice daily to achieve therapeutic effects. However, the specific dosing regimen may vary based on individual patient factors and the prescribing physician’s recommendations.

Important Administration Guidelines

Take fat-soluble vitamins and folic acid at least 4 hours after colesevelam
Administer statins at least 4 hours after colesevelam
Ensure adequate fluid intake when starting colesevelam therapy

Why is timing important when taking colesevelam with other medications? The timing is crucial to prevent potential interactions and ensure proper absorption of other medications and nutrients. Colesevelam can bind to certain substances in the gastrointestinal tract, potentially reducing their absorption if taken simultaneously.

Potential Adverse Effects of Colesevelam

While colesevelam is generally well-tolerated, like all medications, it can cause side effects in some patients. Understanding these potential adverse effects is essential for both healthcare providers and patients to ensure safe and effective use of the medication.

Common Side Effects

Constipation
Dyspepsia
Nausea
Abdominal pain
Flatulence

Are there any serious adverse effects associated with colesevelam? While rare, more serious side effects can occur. These may include severe gastrointestinal issues, vitamin deficiencies (particularly fat-soluble vitamins), and potential drug interactions. Patients should be monitored for these effects, especially during the initial phase of treatment.

Precautions and Monitoring

Regular monitoring of lipid profiles
Assessment of vitamin D and K levels in long-term use
Caution in patients with a history of bowel obstruction or severe gastrointestinal motility disorders
Monitoring of blood glucose levels in diabetic patients

How can patients minimize the risk of adverse effects? Patients can reduce the risk of side effects by following the prescribed dosing regimen, maintaining adequate hydration, and promptly reporting any unusual symptoms to their healthcare provider. Additionally, adhering to a balanced diet rich in fruits and vegetables can help mitigate potential vitamin deficiencies.

Clinically Significant Drug-Drug Interactions

Colesevelam has the potential to interact with various medications due to its mechanism of action and its effect on gastrointestinal absorption. Understanding these interactions is crucial for healthcare providers to ensure safe and effective treatment.

Common Drug Interactions

Statins (e.g., atorvastatin, rosuvastatin)
Thyroid hormones (e.g., levothyroxine)
Oral contraceptives
Warfarin
Certain antibiotics (e.g., ciprofloxacin)

How can drug interactions with colesevelam be managed? The primary strategy for managing these interactions is to separate the administration times of colesevelam and the interacting drugs. Generally, other medications should be taken at least 4 hours before or after colesevelam to minimize the risk of reduced absorption.

Strategies to Minimize Interactions

Careful medication reconciliation
Patient education on proper timing of medications
Regular monitoring of drug levels and therapeutic effects
Consideration of alternative medications when necessary

What role do healthcare providers play in managing colesevelam interactions? Healthcare providers, including physicians and pharmacists, play a crucial role in identifying potential drug interactions, educating patients on proper medication administration, and monitoring for any signs of reduced efficacy or increased side effects due to interactions.

Colesevelam in Special Populations

The use of colesevelam in certain patient populations requires special consideration. These populations may have unique needs or risks that necessitate adjustments in dosing, monitoring, or overall treatment approach.

Pediatric Use

Colesevelam is approved for use in boys and postmenarchal girls aged 10-17 years with heterozygous familial hypercholesterolemia. However, its use should be initiated only after an adequate trial of diet and exercise has failed to achieve the desired LDL-C reduction.

Geriatric Use

Elderly patients may be more susceptible to certain side effects, such as constipation. Careful monitoring and potential dose adjustments may be necessary in this population.

Pregnancy and Lactation

Limited data are available on the use of colesevelam in pregnant or breastfeeding women. The potential benefits and risks should be carefully weighed before prescribing colesevelam in these populations.

How should colesevelam be approached in patients with renal or hepatic impairment? While no specific dose adjustments are required for patients with renal or hepatic impairment, caution should be exercised, and these patients should be monitored closely for any adverse effects or changes in efficacy.

Improving Outcomes: Interprofessional Team Strategies

Optimal management of patients on colesevelam therapy requires a coordinated effort from an interprofessional healthcare team. This collaborative approach can enhance patient care, improve medication adherence, and minimize the risk of adverse effects and drug interactions.

Key Team Members and Their Roles

Physicians: Diagnosis, treatment planning, and overall management
Pharmacists: Medication review, interaction checks, and patient education
Nurses: Patient monitoring, education, and communication
Dietitians: Nutritional counseling and support
Laboratory technicians: Regular lipid profile and glucose monitoring

How can team communication be enhanced to improve patient outcomes? Regular team meetings, shared electronic health records, and clear communication channels can facilitate better information exchange among team members. This improved communication can lead to more coordinated care and better patient outcomes.

Strategies for Improving Care Coordination

Implement standardized protocols for colesevelam therapy
Develop patient education materials for consistent messaging
Establish a system for regular patient follow-ups and monitoring
Create a feedback mechanism for reporting and addressing adverse effects
Utilize technology for real-time communication among team members

What role does patient education play in the success of colesevelam therapy? Patient education is crucial for ensuring medication adherence, proper administration, and timely reporting of side effects. A well-informed patient is more likely to adhere to the treatment plan and achieve better outcomes.

Future Directions and Research in Colesevelam Use

As our understanding of colesevelam’s mechanisms and potential applications continues to evolve, ongoing research is exploring new possibilities for its use and ways to optimize its effectiveness.

Emerging Areas of Research

Potential use in non-alcoholic fatty liver disease (NAFLD)
Exploration of colesevelam’s effects on gut microbiome
Investigation of long-term cardiovascular outcomes
Development of new formulations for improved tolerability

How might future research impact the clinical use of colesevelam? Ongoing studies may lead to expanded indications, improved dosing strategies, or novel combination therapies that could enhance the drug’s efficacy and safety profile.

Challenges and Opportunities

While colesevelam has proven to be an effective tool in managing hyperlipidemia and improving glycemic control, there are still challenges to overcome. These include enhancing patient adherence, minimizing side effects, and optimizing its use in combination with other lipid-lowering therapies.

What potential innovations could address current limitations of colesevelam therapy? Future developments may include extended-release formulations to reduce dosing frequency, improved binding specificity to minimize drug interactions, or novel delivery methods to enhance tolerability and effectiveness.

In conclusion, colesevelam represents a valuable addition to the armamentarium of lipid-lowering and glucose-controlling medications. Its unique mechanism of action, versatility in combination therapy, and potential for expanded indications make it an important subject for ongoing research and clinical optimization. As our understanding of colesevelam continues to grow, healthcare providers can look forward to more refined and effective strategies for its use in managing hyperlipidemia and type 2 diabetes mellitus.

Colesevelam – StatPearls – NCBI Bookshelf

Parth H. Patel; Ahmet S. Can.

Author Information and Affiliations

Last Update: May 1, 2023.

Continuing Education Activity

Colesevelam is an FDA-approved antihyperlipidemic drug. When treating hyperlipidemia, colesevelam should be used in conjunction with restriction of cholesterol and fat intake and exercise and can be used as a monotherapy or combined with an HMG-CoA reductase inhibitor ezetimibe, or niacin. It is approved for the treatment of hyperlipidemia from heterozygous familial hypercholesterolemia in adults and as well as in adolescents (10 to 17 years of age) patients. Colesevelam is also indicated to improve glycemic control in adults with type 2 diabetes mellitus along with diet and exercise.

Objectives:

Identify the mechanism of action of colesevelam.
Describe the potential adverse effects of colesevelam.
Review the potential clinically significant drug-drug interactions of colesevelam.
Outline some interprofessional team strategies for improving care coordination and communication when using colesevelam and improve outcomes.

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Indications

Colesevelam is a bile acid sequestrant that is an FDA-approved drug to be used in adjunct with diet and exercise for a variety of indications. The main indication is to lower an elevated low-density lipoprotein cholesterol (LDL-C) in patients with primary hyperlipidemia and other diseases that cause hyperlipidemia. It can be used as a monotherapy or with an HMG-CoA reductase inhibitor (statin), ezetimibe, or niacin, or a three- or four-drug combination. Another approved use is to reduce LDL-C levels in boys and postmenarchal girls ages 10-17 who have heterozygous familial hypercholesterolemia. For this situation, colesevelam can be used as a monotherapy or with a statin only after a proper trial of diet and exercise has failed. Finally, the last FDA-approved indication is to improve glycemic control in type 2 diabetic adults.

While not an FDA-approved use, colesevelam has been shown to improve stool consistency in patients with irritable bowel syndrome with diarrhea, causing an overall improvement in bowel function.[1] Overall effects were consistent with increased hepatic bile synthesis and luminal bile acid sequestration by colesevelam.[1]

Mechanism of Action

Colesevelam is a novel drug created to help patients lower their LDL cholesterol levels. Its primary mechanism of action is to create nonabsorbable complexes when exposed to bile acids in the GI tract. It forms these complexes due to its numerous hydrophobic side chains, which enhance the binding of bile acids.[2] Once it forms the complexes, the bile acids are no longer able to be reabsorbed to participate in the enterohepatic bile acid recirculation system. This activity causes a reduction in the total amount of bile acids in the body, causing an upregulation of the 7-alpha-hydroxylase enzyme responsible for converting intracellular cholesterol into bile acids. With the need for bile acids increased, hepatic LDL receptors become upregulated to provide enough cholesterol for bile acid synthesis. As more and more cholesterol diverts into creating bile acids, there is an overall decrease in the plasma LDL cholesterol level, along with a decrease in total cholesterol levels.[3]

The main mechanism through which colesevelam reduces plasma glucose levels is not entirely understood. In animal studies, researchers have observed colesevelam increasing the hormone glucagon-like peptide-1, GLP-1, and other incretins. Mice models show that this occurs through the activation of TGR5 secondary to the binding of bile acids in the GI tract. Once GLP1 and other incretins are activated, overall hepatic glycogenolysis becomes suppressed. This suppression occurs because patients with type 2 diabetes have increased hepatic glucose production, contributing to elevated fasting serum glucose levels. By decreasing hepatic glycogenolysis, one can expect a reduction in serum glucose levels. [2][4]

Administration

Colesevelam comes in three major forms that are available to patients. Healthcare providers have the option of choosing an oral tablet formulation, a prepared suspension, as well as a recently approved chewable bar form. The recommendation is to take either once or twice daily to achieve therapeutic effects. Also, patients with susceptibility to fat-soluble vitamin and folic acid deficiencies should take the vitamins at least 4 hours after taking colesevelam to allow for proper absorption of the vitamins. This principle also applies to statins. Statins need to be taken at least 4 hours after taking colesevelam. Patients should be counseled on proper fluid intake once started on colesevelam.

Colesevelam comes in the following formulations:

Adverse Effects

Colesevelam is part of the drug class known as bile acid sequestrants. While overall, very effective and safe to use as a nonsystemic approach to lower cholesterol, tolerability and compliance issues are not uncommon. Colesevelam has the lowest rate of side effects associated with its use, but it still shares the same side effects as the rest of the drugs in its class. Due to the mechanism of action and causing increased bile acid in the gastrointestinal tract, the predominant side effects are gastrointestinal. Symptoms like constipation, diarrhea, gas, as well as nausea, abdominal pain, and weakness are common. Patients have also noted muscle pain to be a side effect of colesevelam.[5] Another notable side effect associated with the use of colesevelam is a significant increase in triglycerides.[6] Also, steatorrhea is a common side effect of these drugs as well. Due to this, patients should receive counsel that they should take this drug at least four hours before ingesting vitamin supplements and statins.[7]

Colesevelam may decrease the bioavailability of many drugs, including but not limited to: amiodarone, oral corticosteroids, cyclosporine (systemic), estrogen derivatives, progesterone, oral contraceptives, ezetimibe, glimepiride, glipizide, glyburide, leflunomide, lomitapide, loop diuretics like furosemide, thiazides, methotrexate, mycophenolate, nonsteroidal anti-inflammatory drugs, olmesartan, phenytoin, pravastatin, niacin, propranolol, raloxifene, tetracyclines, levothyroxine, ursodiol, oral vancomycin, warfarin and fat-soluble multivitamins A, E, D, K. If these drugs are on the treatment regimen of the patient, monitor therapy or consider therapy modification. These drugs require administration either one to two hours before or four hours after colesevelam administration (see product information of the medications mentioned above).

Contraindications

While a generally well-tolerated drug with relatively mild side effects, colesevelam still has a few side effects that healthcare providers should be aware of before prescribing a patient the medication. Clinicians should not give colesevelam to patients with a history of bowel obstruction. Additionally, patients with a history of serum triglyceride concentrations greater than 500mg/dL or a history of hypertriglyceridemia-induced pancreatitis should not be given this drug due to its ability to increase triglyceride levels.[5][8]

Monitoring

Colesevelam has relatively few monitoring needs. While the drug’s desired effect is easily attainable without monitoring, the real monitoring that is necessary is with concomitantly administered drugs. Colesevelam primarily has been shown to decrease levels of fat-soluble vitamins as the drug tends to cause steatorrhea and the malabsorption of these vitamins. Patients with known deficiencies of these vitamins should understand to take their supplements either an hour before or about four hours after the administration of colesevelam.[5]

In addition to fat-soluble vitamins, studies have shown that patients with hypothyroidism that get started on colesevelam show an increase in TSH levels. This increase indicates that colesevelam causes a decreased absorption of levothyroxine. To counter this, healthcare providers should monitor the patient’s TSH levels while on this drug and advise patients to take their levothyroxine four hours after taking colesevelam.[9] Lastly, patients with triglycerides above 300 mg/dL should be given this drug with caution. Due to colesevelam’s side effect of increasing triglyceride levels, patients with already elevated levels above 300 mg/dL are at risk for increased adverse events like triglyceride-induced pancreatitis and other adverse effects associated with high triglyceride levels. [10]

Toxicity

Overall, colesevelam is a very safe drug to use with a long history of clinical use and study. The medication does not cause toxicity outside of the adverse effects mentioned above. Healthcare providers should be on the lookout for adverse effects patients may experience and work with the clinical care team as well as the patient to see if the medication needs to be adjusted or changed to help alleviate the adverse effects. Healthcare providers should also consider using an alternative formulation of the drug if there are side effects, especially gastrointestinal side effects.

Enhancing Healthcare Team Outcomes

Colesevelam is a very safe drug in the class of bile acid sequestrants used for the treatment of various illnesses. While very safe to use, adverse events are possible. As such, all interprofessional healthcare team members should be on the lookout for the adverse effects. Also, the team members should be knowledgeable on the drug and its properties to help advise the patient on the proper information they should know when taking the medication. Clinicians can utilize pharmacist expertise if there is a question on whether the patient can take the drug safely or not and verify if any contraindications or drug-to-drug interactions might exist. Nursing can provide essential information to patients as well as education on common side effects. Also, nursing can monitor the common adverse effects and serious side effects that patients may experience and may require medical attention. Every member of the interprofessional healthcare team has a responsibility to provide the best care to their patients and should be aware of therapies they might be on to help achieve the best possible outcome for the patient. [Level 5]

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References

1.: Camilleri M, Acosta A, Busciglio I, Boldingh A, Dyer RB, Zinsmeister AR, Lueke A, Gray A, Donato LJ. Effect of colesevelam on faecal bile acids and bowel functions in diarrhoea-predominant irritable bowel syndrome. Aliment Pharmacol Ther. 2015 Mar;41(5):438-48. [PMC free article: PMC4493894] [PubMed: 25594801]
2.: Nwose OM, Jones MR. Atypical mechanism of glucose modulation by colesevelam in patients with type 2 diabetes. Clin Med Insights Endocrinol Diabetes. 2013 Dec 08;6:75-9. [PMC free article: PMC3864737] [PubMed: 24348081]
3.: Sonnett T, Robinson J, Milani P, Campbell RK. Role of colesevelam in managing heterozygous familial hypercholesterolemia in adolescents and children. Adolesc Health Med Ther. 2010;1:53-60. [PMC free article: PMC3915789] [PubMed: 24600261]
4.: Brunetti L, DeSantis EH. Patient tolerance and acceptance of colesevelam hydrochloride: focus on type-2 diabetes mellitus. P T. 2015 Jan;40(1):62-7. [PMC free article: PMC4296594] [PubMed: 25628509]
5.: Zema MJ. Colesevelam hydrochloride: evidence for its use in the treatment of hypercholesterolemia and type 2 diabetes mellitus with insights into mechanism of action. Core Evid. 2012;7:61-75. [PMC free article: PMC3426253] [PubMed: 22936894]
6.: Aggarwal S, Loomba RS, Arora RR. Efficacy of colesevelam on lowering glycemia and lipids. J Cardiovasc Pharmacol. 2012 Feb;59(2):198-205. [PubMed: 21983746]
7.: Bays H, Jones PH. Colesevelam hydrochloride: reducing atherosclerotic coronary heart disease risk factors. Vasc Health Risk Manag. 2007;3(5):733-42. [PMC free article: PMC2291317] [PubMed: 18078024]
8.: Sekhri K, Saha L. Colesevelam hydrochloride: A novel agent in patients with type 2 diabetes. Int J Appl Basic Med Res. 2011 Jul;1(2):113-5. [PMC free article: PMC3657969] [PubMed: 23776789]
9.: Weitzman SP, Ginsburg KC, Carlson HE. Colesevelam hydrochloride and lanthanum carbonate interfere with the absorption of levothyroxine. Thyroid. 2009 Jan;19(1):77-9. [PMC free article: PMC2858370] [PubMed: 19119983]
10.: Kaufman MB. Drug-induced pancreatitis: A Potentially Serious and Underreported Problem. P T. 2013 Jun;38(6):349-51. [PMC free article: PMC3737994] [PubMed: 23946630]

: Disclosure: Parth Patel declares no relevant financial relationships with ineligible companies.
: Disclosure: Ahmet Can declares no relevant financial relationships with ineligible companies.

Colesevelam Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Uses

This medication is used along with a proper diet and exercise to lower cholesterol in people with high levels of cholesterol in the blood. Lowering cholesterol decreases the risk of heart disease and helps prevent strokes and heart attacks.Colesevelam is also used along with a proper diet and exercise to lower high blood sugar in people with type 2 diabetes. Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke. Colesevelam belongs to a class of drugs called bile acid-binding resins. Bile acid is a natural substance the liver makes by using cholesterol. This medication works by removing bile acid from the body. This causes the liver to make more bile acid by using cholesterol, which reduces cholesterol levels in the blood. It is not known how colesevelam works in lowering blood sugar.

How to use Colesevelam HCL

Take this medication by mouth with a meal as directed by your doctor, usually 1 to 2 times daily. Take the tablet form with a liquid (such as water, milk). If you have trouble swallowing the tablet, talk to your doctor about switching to the powder form of this medication.

If you are using the powder form of this medication, pour the contents of one packet into a glass. Add one cup (8 ounces/240 milliliters) of water, fruit juice, or diet soda. Stir the mixture well and drink all of it. Do not take the powder without mixing it in liquid.

Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time(s) each day.

It may take several weeks before you get the full benefit of this drug.

Colesevelam may decrease the absorption of other products you may be taking. Some examples include cyclosporine, glipizide, glimepiride, glyburide, levothyroxine, and phenytoin, as well as birth control pills that contain ethinyl estradiol and norethindrone. Take other medications as directed by your doctor, usually at least 4 hours before taking your colesevelam dose. Ask your pharmacist if you are not sure when to take your medications.

Side Effects

Constipation and upset stomach may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

To prevent constipation, eat dietary fiber, drink enough water, and exercise. You may also need to take a laxative. Ask your pharmacist which type of laxative is right for you.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: nausea/vomiting, stomach/abdominal pain, trouble swallowing, unusual bleeding/bruising.

This medication does not usually cause low blood sugar (hypoglycemia). Low blood sugar may occur if this drug is prescribed with other diabetes medications, or if you do not consume enough calories from food, or if you do unusually heavy exercise.

Symptoms of low blood sugar include sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. It is a good habit to carry glucose tablets or gel to treat low blood sugar. If you don’t have these reliable forms of glucose, rapidly raise your blood sugar by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

Symptoms of high blood sugar (hyperglycemia) include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking colesevelam, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: pancreatitis (caused by high triglyceride levels), high triglyceride levels, trouble swallowing, stomach/intestinal disorders (such as constipation, blockage, gastroparesis), recent major intestinal surgery, hemorrhoids.

Because this drug can interfere with the absorption of certain vitamins (such as vitamins A, D, E, K) when used for a long period of time, your doctor may direct you to take a multivitamin supplement. Take the multivitamin at least 4 hours before taking your colesevelam dose.

The powder form of this medication may contain aspartame. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this medication safely.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Tell your doctor if you are pregnant before using this medication.

This medication is unlikely to pass into breast milk or harm a nursing infant. Consult your doctor before breast-feeding.

Interactions

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Do not share this medication with others.

Lab and/or medical tests (such as blood cholesterol levels, blood sugar) should be done while you are taking this medication. Keep all medical and lab appointments. Consult your doctor for more details.

Lifestyle changes that may help this medication work better include exercising, stopping smoking, and eating a low-cholesterol/low-fat diet. Consult your doctor for more details.

Attend a diabetes education program to learn more about how to manage your diabetes with medications, diet, exercise, and regular medical exams.

Learn the symptoms of high and low blood sugar and how to treat low blood sugar. Check your blood sugar regularly as directed and share the results with your doctor.

If you miss a dose, take it as soon as you remember with a meal. If it is near the time of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.