Should You Take the Supplement Lysine? Learn About Lysine Benefits

Lysine is an essential amino acid and a building block of protein that is found in foods and supplements. The best food sources of Lysine are animal protein and legumes, but Lysine is also found in dairy products, nuts, and tofu. Lysine helps in calcium absorption, building muscle protein, recovering from surgery or sports injuries and the body’s production of hormones, enzymes, and antibodies.

Researchers have studied the impact of Lysine on a variety of conditions, including stress, metabolic disorders, strength enhancement, Aphthous ulcers (commonly known as canker sores) and the Herpes simplex virus. Most of the studies involving Lysine have been small, but here is some of the research that’s encouraging.

Herpes simplex virus (HSV-1) infections are common, with an estimated 90 percent of American adults having been exposed to HSV-1. HSV-1 is the main cause of herpes infections on the lips and mouth, including cold sores and fever blisters. In some, the virus is dormant, while others suffer from repeated flare-ups. While some studies suggest that regular use of Lysine can help prevent flare-ups of cold sores and herpes, others showed no benefit, potentially due to the amount of Lysine administered daily in each study.

In a double-blind placebo-controlled study of 52 participants with a history of HSV-1 flare-ups, the treatment group received 3,000 mg (three grams) of Lysine daily for six months. In comparison to the control group, the treatment group experienced an average of 2.4 fewer HSV-1 flare-ups than the placebo group. Also, the Lysine group’s flare-ups were significantly less severe and healed more quickly. While this study called for 3,000 mg of Lysine per day, in general, the studies that had subjects take a minimum of 1,000 mg per day had positive results.

Aphthous ulcers, or canker sores, are painful open sores in the mouth. While these mouth ulcers may be caused by a viral infection, canker sores have also been linked to stress, hormonal changes, and food allergies. About 10 percent of our population suffers regularly with canker sores, and women, more often than men, seem to have them. There’s a small study that suggests 500 mg of Lysine daily works well for ulcer prevention with 1,000 mg daily used for treatment.

Individuals who suffer from canker sores or herpes outbreaks may find the supplement Lysine helpful in managing their condition. However, high doses of Lysine have caused gallstones and elevated cholesterol levels, so if you have high cholesterol, heart disease or high triglycerides, you should talk with your physician before taking Lysine supplements.

Article provided by Jill Turner, President of Cooper Concepts

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May 1, 2019

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L-Lysine – two farm kids Natural Foods

One of the best nutritional treatments for the Herpes simplexvirus is L-Lysine, a well-known amino acid. L-Lysine is one of the nine essential amino acids that the body needs to manufacture proteins. It is considered “essential” because the body cannot manufacture L-Lysine.

As an amino acid it is involved in tissue repair, production of hormones and enzymes and in the synthesis of collagen and bone health. Most persons get adequate L-Lysine in their diet but those who have problems with the herpes virus may need supplemental L-Lysine to keep the virus in check.

This approach originally came from research showing that lysine has anti-viral activity against the Herpes simplex virus in test tube studies. L-Lysine works to inhibit the growth of the virus by blocking its use of another amino acid – arginine.

In order for L-Lysine therapy to really be effective in preventing cold sores and outbreaks of genital herpes it is important that the diet also is low in arginine. Avoid foods high in arginine like chocolate, peanuts, almonds and other nuts, and seeds. It is also a good idea to focus on foods that are high in L-Lysine such as most vegetables, legumes, fish, turkey, and chicken. Follow these dietary guidelines and take one gram of L-Lysine three times daily with meals for maximum benefit. In one double-blind study, after 6 months, L-Lysine was rated as effective or very effective in 74% of cases compared to only 28% for those receiving the placebo.

L-Lysine also plays a role in helping the body to absorb and conserve calcium, so it may also be important for those who have a predisposition to osteoporosis.

L-Lysine should be an essential part of a nutritional protocol to prevent flare-ups of the herpes simplex virus, in whatever form it may take. Combine therapeutic dosages of L-Lysine with a low-arginine diet and extra nutritional help from vitamin C and zinc for effective control of this virus.

8 Lysine Benefits + Foods High In Lysine

Lysine is an essential amino acid that plays a vital role in the body and is a necessary part of the diet. Find out what lysine is, what are its benefits and side effects, and which foods are great sources of this amino acid.

What Is Lysine?

Lysine is an essential amino acid that plays an important role in the creation of proteins in the body. The human body is unable to produce lysine itself. This means that lysine must come from external sources — primarily food.

Some biological functions of lysine include [1, 2, 3]:

• Serving as a building block for proteins
• Playing an important role in histone modification (which affects gene expression)
• Providing structure to collagen
• Regulation of calcium levels

Lysine, as an oral supplement or lip balm, is often used for treating and preventing cold sores. Some other popular purported health benefits include improving athletic performance, canker sore symptoms, and schizophrenia symptoms.

However, there is a lack of clinical studies to support most of these claims. We’ll dive into the research concerning lysine in the following sections.

Snapshot

Proponents

• May help prevent or treat cold sores
• May help prevent or treat canker sores
• May reduce anxiety
• May reduce schizophrenia symptoms
• May help improve diabetes

Skeptics

• Lack of strong clinical research to support health claims
• Diet usually provides more than enough lysine
• Supplements may cause diarrhea and stomach pain

Purported Health Benefits Of Lysine

Possibly Effective For:

1) Treatment and Prevention of Herpes (Cold Sores)

Herpes labialis, more commonly known as cold sores, are caused by an infection by the herpes simplex virus. There is some evidence that lysine, taken orally, is possibly effective for treating or preventing cold sores.

A number of older clinical trials have found that oral lysine supplements may help prevent the recurrence of cold sores as well as improve the severity and duration of symptoms [4, 5, 6, 7, 8].

According to a more recent pilot study of 30 people, a specific herbal-based product containing lysine and zinc may also reduce the duration of cold sore episodes [9].

However, all of these studies had relatively small sample sizes. In one systematic review looking at various treatments for the prevention of cold sores, the researchers suggest that the evidence supporting lysine is of very low quality [10].

Insufficient Evidence For:

The following purported benefits of lysine are only supported by limited, low-quality clinical studies. There is insufficient evidence to support the use of lysine for any of the uses listed below. Remember to speak with a doctor before taking lysine. It should never be used as a replacement for approved medical therapies.

2) Canker Sores

While they appear similar to cold sores, canker sores do not occur on the surface of the lips and are not contagious. There is also much less research on the effectiveness of lysine for canker sores.

Only one older study suggests that 500 mg of lysine daily may help prevent canker sores [11].

3) Anxiety

A 3-month randomized study performed in communities in Syria found that wheat fortified with lysine may reduce anxiety and stress [12].

According to a randomized placebo-controlled study of 108 healthy Japanese adults, oral supplementation with both lysine and arginine (another essential amino acid) may reduce anxiety and cortisol levels [13].

4) Schizophrenia

A small randomized placebo-controlled study of 10 patients with schizophrenia found that high dose supplementation of lysine at 6 g per day (in combination with conventional antipsychotic medication) may decrease the severity of positive symptoms [14].

Another randomized placebo-controlled trial of 72 schizophrenia patients also examined the effects of high dose (6 g per day) lysine supplements as an add on to conventional treatment. In contrast to the previously mentioned study, researchers found potential improvements to negative and general symptoms, but not for positive symptoms [15].

5) Diabetes

A small study of 8 patients with type 2 diabetes found that oral lysine supplements may lower blood glucose levels [16].

Another pilot study of 77 diabetic patients also found that oral supplementation with lysine may decrease blood glucose levels and improve insulin sensitivity [17].

In addition, a small study of 13 healthy subjects shows that lysine may decrease blood glucose levels while increasing glucagon and insulin levels [18].

6) Muscle Strength

According to a study of 40 healthy men, 8 weeks of a high lysine diet (defined as 80 mg/kg each day) may improve muscle strength compared to a low lysine diet [19].

7) Bone Health

Two studies of 30 and 45 patients with osteoporosis found that dietary supplementation with lysine may improve the absorption of calcium. According to researchers, this may be helpful for those with osteoporosis [3].

8) Pressure Ulcers

Pressure ulcers, also known as bedsores, are caused by prolonged pressure on the skin, usually from staying in one position for too long. This type of ulcer is especially a concern in patients that are hospitalized for long periods of time [20].

A study of 50 hospitalized patients found that a specific cream containing lysine and hyaluronic acid may help reduce the size of ulcers and healing time [20].

Safety of Lysine

Lysine is generally considered possibly safe. Studies have used oral lysine supplements for up to a year without any safety concerns. Topical forms of lysine have only been studied in short-term trials — their long-term safety is unclear [4].

There is also insufficient evidence to determine if lysine supplements are safe to use during pregnancy or breastfeeding.

Side Effects

The most commonly reported side effects of lysine supplementation include stomach pain and diarrhea.

Precautions

Calcium Absorption

There is some evidence that lysine may increase calcium absorption. Those with too much calcium in the blood (hypercalcemia) may need to avoid lysine supplements [3].

Kidney Disease

There is one case report of a person developing chronic renal failure after taking high amounts of lysine over a five-year period [21]

Intolerance to Lysinuric Protein

Lysinuric protein intolerance is a genetic condition that impairs the absorption of amino acids like lysine. Supplementation with lysine in people with this condition may cause diarrhea and stomach cramps [22, 23].

Supplementation

In the following sections, we’ll discuss the common forms and dosages of lysine supplements that are commercially available. Lysine supplements are not approved by the FDA for medical use. Regulations set manufacturing standards for supplements, but that does not guarantee that they are safe or effective. Speak with your doctor before supplementing.

Forms

Lysine is commercially available as capsules, tablets, ointments, lip balms, and as a powder.

Most products refer to lysine as L-lysine, which is the biologically active form of the amino acid.

Dosage

There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions.

For cold sores, clinical trials have used doses that range from 500 to 3,000 mg total each day [7].

The strength of commercially available oral lysine supplements typically ranges from 500 to 1,000 mg per dose. Manufacturers usually recommend taking 1 to 3 doses each day.

Natural Sources of Lysine

The body is unable to produce lysine, so it is important to get enough lysine in the diet. Luckily, in countries like the U.S., most people get more than enough lysine from meat and vegetable sources [24].

The recommended intake of lysine for adults is 30 mg/kg. According to some studies, most people in the Western world get about 40-180 mg/kg of lysine [24].

Some great sources of lysine include:

• Lean beef and lamb – 3582 mg/100g
• Parmesan cheese – 3306 mg/100g
• Poultry (turkey, chicken) – 3110 mg/100g
• Pork – 2757 mg/100g
• Soya beans and products (tofu, protein powder, flour) – 2634 mg/100g
• Tuna – 2590 mg/100g
• Shrimp – 2172 mg/100g
• Pumpkin seeds – 1386 mg/100g
• Eggs – 912 mg/100g
• White beans – 668 mg/100g [25]
• Other fish (cod, sardine) and shellfish
• Nuts, seeds, eggs, beans, and lentils
• Spirulina and fenugreek seeds [26]

Lysine for FHV? Researchers Say Don’t Bother

By Ken Niedziela, News Editor

Originally published in the January 2016 issue of Veterinary Practice News.

Two virologists are urging veterinarians to immediately stop lysine supplementation in cats suffering from feline herpesvirus-1 because they say the therapy is ineffective.

Their conclusion, published Nov. 16 in the online journal BMC Veterinary Research, drew a measured response from two experts in the field who said anecdotal reports of successful lysine use leave open the possibility that the therapy does work.

Husband-and-wife virologists Sebastiaan Bol, MS, Ph.D., and Evelien M. Bunnik, MS, Ph.D., reached the conclusion after conducting a systematic review—essentially a study of previous lysine studies.

Bol, who like his wife is employed at the University of California, Riverside, began the review after their 8-year-old cat, Aguereberry, was diagnosed with FHV-1, a highly contagious infection of the upper respiratory system. Their veterinarian recommended lysine nutritional supplements to treat and manage the disease.

“With my background in biology and nutrition, I was very suspicious, and I started clicking—doing some searches online—and I was not very convinced,” Bol said. “So I started looking into more and more of the publications, and it was really shocking to see that there’s absolutely no evidence [that lysine is effective in cats].”

Bol and Bunnik’s research article looked at seven studies of lysine and FHV-1—two in vitro studies and five involving cats—as well as 10 studies of human herpesvirus-1. Examining papers dating to the 1970s, Bol found that the lysine recommendation originated with a human study.

The veterinary studies offered no scientific proof of lysine’s efficacy in cats, he said. Those papers, he discovered, all stopped short of advocating an end to lysine supplementation in FHV-1 cases.

What Bol didn’t know at first was how often veterinarians prescribed lysine to FHV-1 cats. Did Aguereberry’s doctor follow the crowd or was she an exception?

“So I did a survey and found that over 90 percent of the veterinarians are recommending it,” Bol said.

He asked 68 cat hospitals spread across the United States, Australia and the United Kingdom whether they prescribed lysine. Of the 23 hospitals that replied, 21 of them, or 91 percent, did.

FHV researcher David Maggs, BVSc, Dipl. ACVO, a professor of veterinary ophthalmology at the University of California, Davis, School of Veterinary Medicine, complimented Bol for that additional research and for Bol and Bunnik’s overall work.

“The authors have done a tremendous review of the literature,” Dr. Maggs said. “It seems to be very comprehensive, very complete. They turned up one or two articles that I wasn’t aware of, and then they certainly turned up all the articles that I am aware of.”

Five of the seven veterinary studies were co-authored by Maggs. But none of Maggs’ studies reached the same conclusion as Bol’s: a recommended “immediate stop of lysine supplementation because of the complete lack of any scientific evidence for its efficacy.”

“I was surprised by the conclusion,” Maggs said. “The conclusion seems to be, at least for science, very boldly stated. Scientists are well known for not really stating things very boldly, and that’s one of the criticisms we get.

“To say that there was no evidence strikes me as a little bit odd because they point out in their own manuscript that there has been at least one study that suggested a benefit.”

Bol responded that of the clinical feline studies he examined, “maybe one study” found something, “but that was only after they very narrowly looked at one specific thing.”

He also noted that the clinical studies had small sample sizes and that one study showing some effectiveness “only compared four cats to four other cats.”

Anecdotal evidence should not be discarded, Maggs said.

“I have clients who tell me that every time they take the cat off lysine the problem returns,” he said. “Now that’s totally anecdotal evidence, but … I’m using it as an example that we should not recommend a blanket immediate cessation of therapy in all cats.

“There are clearly some cats who respond well in a disease that sometimes has very subtle signs,” he added. “Maybe it’s just as well to leave those cats on lysine if the clients genuinely feel that it’s making a difference.”

Maggs’ comment was supported by Texas feline practitioner Gary D. Norsworthy, DVM, Dipl. ABVP, who co-edited “The Feline Patient, 4th Edition.”

“[Lysine] is used frequently by many of my clients at the recommendation of Dr. Google,” Dr. Norsworthy said. “Some cats have a very convincing response in spite of what the science says.

“I do not recommend it as a first-line treatment for feline herpesvirus-1,” he said, “but I also do not discourage it. Cats are not very conversant with the literature. Its use should be based on response, whether scientific or not.”

The textbook “The Feline Patient” acknowledges some uncertainty about lysine. One part states:

“For several years, lysine (250-500 mg/cat q12h PO) has been thought to have activity against the acute and chronic phases of FHV-1 infection. However, two recent studies failed to demonstrate efficacy of lysine against upper respiratory infections in groups of shelter cats. In one of these studies, lysine therapy was associated with worsening of clinical signs and increased detection of FHV-1 viral DNA in oropharyngeal and conjunctiva mucosal samples. As such, use of lysine for treating FVH-1 must be reconsidered.”

Bol suggested that practitioners swayed by anecdotal evidence should consider another possible reason for improvements in FHV cats: the passage of time.

“When people bring their cats to the clinic … the symptoms are pretty severe and [veterinarians] prescribe the lysine,” Bol said. “Over time, with or without treatment, symptoms will improve. When you give the cat lysine, symptoms will improve. Is it because of the lysine?

“They have absolutely no way to say that it is because of the lysine,” he added. “They have no way to say that the same improvement would occur if they would not have treated the cat with lysine. That’s why you need a control group [in studies]. Anecdotal evidence is no evidence. … Anecdotal evidence is a contradiction in terms.”

Bol and Bunnik’s paper, available at http://bit.ly/1O666oi, noted that scientists believe lysine does not possess antiviral properties. Rather, some researchers propose that lysine works by lowering arginine levels.

And therein lies another issue, Bol stated.

“Lowering arginine levels is highly undesirable since cats cannot synthesize this amino acid themselves,” he and Bunnik wrote. “Arginine deficiency will result in hyperammonemia, which may be fatal.”

Having studied FHV himself and after reading the virologists’ systematic review, Maggs remained wary.

“[I] recommend perhaps a moderation of the final conclusion because I don’t think we can say that this drug should be stopped in all cats with herpesvirus,” Maggs said. “I think they’ve introduced a useful cautionary note of whether it should be initiated in every cat, but recommending an immediate cessation is probably a stronger conclusion that I would have drawn from the same data.”

Going by the Book

An industry authority, The Merck Veterinary Manual, has backed away from endorsing lysine therapy in feline herpesvirus cases. The most recent print edition, published in 2010, suggested lysine’s use.

The online version has since been updated to read: “Previously, lifelong oral L-lysine (250-500 mg/day) was recommended to help prevent or reduce the severity of recurrent feline herpesvirus infections. However, recent work has shown that oral L-lysine can actually exacerbate feline herpesvirus infections.”

The 11th edition of the manual, due out in February, will reflect the change, an editor told virologist Sebastiaan Bol in an email. 

Hitting Herpes Hard – POZ

Infection with herpes simplex virus is like having an obnoxious relative come to visit but never leave: You can’t get rid of him, so you learn to cope. Oral or topical antiviral drugs, particularly acyclovir (brand name Zovirax), are the standard treatments for herps simplex virus 1 (which causes eruptions on the face and mouth) and 2 (which causes genital sores). Acyclovir is highly effective and only rarely has side effects-but if you lack health insurance, it costs a bundle.

So for some PWAs, alternative remedies may be worth trying. Supplements such as zinc, iron, calcium and vitamins B-12 and C may help resolve deficiencies common in people with herpes, and external vitamin E oil may help soothe the sores. But the nutrient with the best track record remains the amino acid lysine. The few studies conducted on lysine have found it effective in controlling the occurrence, severity and healing time of herpes outbreaks. In two studies, an average dose of 500 milligrams of lysine daily kept herpes in long-term remission; during flare-ups, one to six grams daily (taken between meals) hastened healing.

James Scutero, a PWA living in New York City who developed an Internet newsgroup called misc.health.aids, says, “My face clears up whenever I use a lysine supplement, I can pop up to six grams a day without side effects.” (You might experiment to find the most effective dose; studies indicate that at least eight grams daily can be taken safely.) Scutero also applies lysine cream to genital lesions with good results.

Some alternative practitioners maintain the supplement is most effective at treating the early stages of oral, rather than genital, herpes. Others claim it has broader benefits. John Harris, a herbalist and radio health-program producer in New York City, finds that lysine can reduce the frequency of herpes outbreaks among its clients. He also recommends a dietary approach, both for treatment and prevention of future attacks: Eating foods higher in lysine than in arginine, another amino acid. Arginine promotes replication of the herpes simplex virus, while lysine suppresses it-and decreases the body’s uptake of arginine.

Lysine-rich foods include fish, chicken, beef, lamb, cheese, beans, brewer’s yeast, mung bean sprouts and most fruits and vegetables. Avoid foods high in arginine: Chocolate, in particular, and also nuts and seeds.

But as always with nutrition, there’s a twist. Lark Lands, a Georgetown, Colorado-based HIV-nutrition educator and author of Positively Well, cautions, “Taking lysine supplements long-term [as a prophylactic] is not advisable, since it might cause an imbalance or deficiency in other amino acids-particularly arginine, which is required for several important functions in the body, including production of growth hormone.” Lands does agree with Harris’ dietary guidelines, since adequate amounts of arginine can be derived from other foods, and lysine at dietary levels will not block all uptake of arginine.

Any self-medication for serious or persistent conditions should be done in consultation with a qualified health practitioner. Send your home remedies to POZ Partner, 349 West 12th Street, New York, NY 10014.

L-Lysine, 500 mg, 50 Capsules

L-Lysine is an essential amino acid that cannot be manufactured by the body so must be consumed in the diet. It improves calcium absorption and is needed to support proper growth and bone development. L-Lysine also supports the immune system and can assist the body to decrease the occurence and severity of seasonal symptoms.

Amino acids are needed by the body to rebuild and repair tissues and muscles, as well as to assist in making enzymes, proteins, and antibodies. L-Lysine is one of the eight essential amino acids that cannot be manufactured by the body. Not only is it needed to support proper growth and bone development, but L-Lysine also improves calcium absorption and helps maintain nitrogen balance in the body.

L-Lysine:

• Convenient, easy-to-swallow capsules.
• Suggest selling with calcium; promotes optimal absorption.
• CONTAINS NO artificial colors, flavors or preservatives; no wheat, gluten, milk, eggs, peanuts, tree nuts, soy, crustacean shellfish or fish. Suitable for vegans.
• Vegetarian Formula
• Supports growth and bone development
• Decreases severity and occurrence of cold sores
• One of the eight Essential Amino Acids – must be ingested

Used For:

• Immune Support
• Amino Acid

Interferes with the replication of herpes virus, helpful for those with cold sores or genital herpes. Lysine deficiency can occur by inadequate diatary intake, it is one of the 8 essential amino acids that must be ingested. The body cannot manufacture it. Lysine defiency is also caused by exessive arginine intake, found in nuts, chocolate, peanutbutter, gelatin, wheat, soy and caffeine.

Calcium increases absorption of Lysine and helps maintain nitrogen balance, imprtant for protein retention and muscular repair.

View Product Information Sheet (PDF)

Surgical And Cosmetic Dermatology – Lysine hydrochloride use in the prophylaxis of herpes simplex in facial technology-aided procedures

Original Article

http://www.dx.doi.org/10.5935/scd1984-8773.20191111273

Lysine hydrochloride use in the prophylaxis of herpes simplex in facial technology-aided procedures

Uso do cloridrato de lisina na profilaxia do herpes simples nos procedimentos faciais com tecnologias

Victor Bechara de Castro; Maria Eduarda Pires; Paula Regazzi de Gusmão; Alexandre de Almeida Filippo; Manuela da Silva

Department of Laser, Santa Casa de Misericórdia – Rio de Janeiro (RJ), Brazil

Received on: 22/10/2018
Approved on: 22/12/2018
Study conducted at the Dermatologia Professor Rubem David Azulay, Santa Casa de Misericórdia do Rio de Janeiro – Rio de Janeiro (RJ), Brazil.
Financial support: None
Conflict of interests: None

Correspondence:

Dr. Victor Bechara de Castro
R. Santa Luzia, 206 Centro
20020-022, Rio de Janeiro, RJ Brasil
E-mail: [email protected]

Abstract

INTRODUCTION: Lysine is one of the essential amino acids, with a role in the prophylaxis of recurrent orolabial herpes simplex that has been demonstrated in scientific studies. Facial resurfacing procedures with laser and other technologies can reactive herpes simplex.
OBJECTIVE: To evaluate the incidence of cases of orolabial herpes in patients submitted to treatments with fractional ablative and non-ablative lasers and robotic microneedling, under prophylactic l-lysine.
METHODS: A sample of 100 was selected to have prophylactic l-lysine for herpes simplex. A re-evaluation of all patients was conducted seven days after laser treatment. If herpes infection was detected, doses of oral antiviral similar to those used for herpes-zoster treatment would be prescribed, guided by the literature.
RESULTS: Only 2% of the sample demonstrated herpes simplex after the procedure with prophylactic l-lysine. Both patients underwent ablative fractional laser treatment and had past history of herpes simplex infection.
CONCLUSIONS: Besides the low cost, l-lysine is a natural product that proved to be safe and effective for the prophylaxis of herpes simplex in resurfacing procedures, with a similar or lower rate of viral activation to the use of antivirals.

Keywords: Herpes Simplex; Herpes Labialis; Lysine; Laser Therapy; Lasers

INTRODUCTION

A L-lysine is one of the eight essential amino acids, and its activity in the prophylaxis of recurrent orolabial herpes simplex and shortening of the course of this infection has been demonstrated in scientific studies.¹ The mechanism of action involved is a result from the interaction of lysine with arginine, an essential amino acid for the replication of the herpes virus. Lysine increases renal and intestinal clearance of arginine and competes with its cell transport, besides inducing the activation of the enzyme arginase.¹

The cycle of viral replication of herpes simplex ranges from four to 12 hours and usually results in cell death. However, the virus remains latent in neuronal cells, until the moment of its reactivation, such as in treatments of laser resurfacing.²

Griffith et al demonstrated reduction of the recurrences and of the recovery time in cases of herpes simplex when they submitted 45 patients with recurrent orolabial herpes to treatment with daily doses of lysine, 312-1200mg.³

Patients submitted to procedures of facial laser resurfacing are susceptible of HSV reactivation. One study with 907 patients undergoing this procedure with CO₂ laser reported an incidence of acute HSV infection of 3%, which dropped to 1% after prophylaxis with aciclovir. Data published in 2001 regarding rates of herpes simplex before the use of antivirals in these procedures are from a retrospective analysis and clinical trial with historical control. In the first, six (50%) out of 12 patients with history of orofacial herpes simplex submitted to dermabrasion or phenol chemical peel developed lesions after the procedure. In the clinical trial, prophylaxis with famciclovir was conducted in 121 patients submitted to facial CO₂ laser, using historical control of 127 patients with the same procedure, without prophylaxis, that showed a reactivation rate of 9.4%.^4,5

The exact dose and time of treatment with l-lysine necessary to reduce episodes of orolabial herpes simplex have not been established. We must take into consideration in prophylactic treatment the time needed for reepithelization, which, after ablative fractional treatments, usually lasts from 5.5 days (Erbium-Yag) to 8.5 days (CO₂ laser).⁶

Griffith RS et al, in a multicentric, double-blind, case-control study, demonstrated that a daily dose of 3000 mg of L-lysine for 6 months was capable of reducing the number of episodes of orolabial herpes and the recovery time, besides reducing he severity of the symptoms.⁷ In their study, Mc Cune MA et al saw a similar result in patients on a daily dose of 1248mg of L-lysine, even though they have not noticed reduced recovery time.⁸

The objective of this study is to evaluate the incidence of cases of orolabial herpes in patients submitted to treatments with fractional, ablative and non-ablative laser and robotic microneedling and the prophylactic use of L-lysine.

METHODS

Patients older than 18 years, who would be electively submitted to resurfacing with fractional ablative and non-ablative laser or robotic microneedling (with or without radiofrequency), that had a previous history of infection by herpes simplex virus or not, performed prophylaxis with one capsule of L-lysine 500mg three times daily with meals, starting seven days before and continuing for seven days after the procedure. A reevaluation of patients was performed seven days after the laser session. In cases where herpetic infection was detected, doses of oral antivirals equivalent to those used for the treatment of herpes-zoster were prescribed, as advised in the literature.

Exclusion criteria: Pregnancy or breastfeeding, current prophylaxis for herpes simplex with other medications, hypersensitivity to any of the components of the L-lysine formulation, those with kidney and/or liver diseases.

Local: Sector of Laser, Instituto de Dermatologia Prof. Rubem David Azulay, Santa Casa de Misericórdia do Rio de Janeiro. The research was approved by the Committee of Ethics in Research, with a sample of 100 patients.

Description of the methods used to evaluate results: The evaluation of results was conducted through the clinical analysis of the cases of orolabial herpes activation, comparing them according to the procedure performed and previous history of herpes

simplex.

RESULTS

One hundred patients were submitted to procedures with technologies on the face and instructed to have prophylactic L-lysine. Most of the sample was composed by females (Graph 1).

The procedure most often performed was fractional ablative laser, followed by microneedle radiofrequency and fractional non-ablative laser (Graph 2).

A previous history of labial herpes simplex was reported by 21% of patients.

Only 2% of the sample developed herpes simplex after the procedure with the use of prophylactic lysine hydrochloride. These patients underwent treatment with fractional ablative laser and reported previous infection by herpes simplex (Graph 3).

DISCUSSION

Griffit et al, as well as Pedrazini et al, showed positive results in the reduction of incidence and recurrence of herpes simplex with the administration of L-lysine for 6 months and 1 month, respectively.^7,9

Despite the common occurrence of reactivation of herpes simplex virus after procedures of facial resurfacings, there still are no protocols in the literature for the use of L-lysine as a prophylactic agent.

In this study, with the use of prophylactic L-lysine, we demonstrated that 2% of the patients had lesions of labial herpes simplex after procedures with technologies. These cases were mild, treated with antiviral, progressing with no unsightly scars or other complications.

Our study is in accordance with the results by Wall et al, where 1.1% of the patient sample that underwent sessions of CO₂ fractional ablative laser had lesions of herpes simplex even while using prophylactic famciclovir 250mg/day, started two days before and maintained for five days after the procedure. These patients had no previous history of orofacial infection by herpes simplex.⁵

The studies by Alster & Nanni and Naouri et al, show higher rates of complications with the appearance of herpetic lesions after fractional ablative laser. In the first, 10.1% of patients had clinical lesions consistent with herpes simplex during prophylactic famciclovir for 11 days. The second demonstrated incidence of herpes in 10.6% of patients using valaciclovir during seven days.^10,11

In an analysis involving 730 patients submitted to sessions of fractional ablative and non-ablative lasers with prophylactic valaciclovir 500mg/day initiated 48 hours before the procedure, Cohen et al demonstrated the occurrence of only five cases of viral reactivation, that progressed with no formation of scars or unaesthetic outcomes.¹²

In the studies by Gilbert & McBurney, as opposed to most studies found in the literature, there were no reports of the occurrence of herpetic lesions after the procedure. However, it is worth highlighting that in this case, only laboratory criteria were used to detect the viral infection, even if there had been clinical lesions consistent with the condition. Of 84 patients analyzed by Gilbert & McBurney, 16 showed pustules/vesicles, erosions, pruritus or burning sensation after the procedure. Four of these cases grew Staphylococcus in culture, four had the presence of gram-negative organisms and one individual grew Candida albicans in culture. The other eight cases had negative viral, fungal and bacterial cultures.¹³

Most authors argument that clinically suspicious cases should be considered herpes simplex, since characteristic signs and symptoms of herpetic lesions are not found in the damaged epithelium. Moreover, traditional laboratory methods used to detect HSV (Tzanck smear, culture) might be less accurate in this scenario.¹⁰

No adverse events were reported associated to the use of lysine hydrochloride in our cases. On the other hand, the occurrence of nausea and headaches associated to the prophylactic use of valaciclovir and famciclovir is relatively frequent.⁵

CONCLUSION

Besides the low cost, lysine used in this study is a natural product that proved to be safe for the use as pre-procedure prophylaxis, with lower or similar rates of herpetic lesions found in the literature. Our study is pioneer, and randomized controlled clinical trials are needed to confirm the efficacy of this drug for this purpose. However, we can conclude that L-lysine showed positive results, being a new option in the therapeutic arsenal of the dermatologist.

ACKNOWLEDGEMENTS

We thank the patients who committed to finishing the protocol.

CONTRIBUIÇÃO DOS AUTORES:

Victor Bechara de Castro | ORCID 0000-0003-1651-2919

Statistical analysis, approval of the final version of the original, design and planning of the study, preparation and writing of the original, data collection, analysis and interpretation, active participation in mentoring the research, intellectual participation in propaedeutics and/or therapeutics of the cases studied, critical review of the literature, critical review of the original.

Maria Eduarda Pires | ORCID 0000-0002-5755-5328

Statistical analysis, approval of the final version of the original, design and planning of the study, preparation and writing of the original, data collection, analysis and interpretation, intellectual participation in propaedeutics and/or therapeutics of the cases studied, critical review of the literature, critical review of the original.

Paula Regazzi de Gusmão | ORCID 0000-0002-7060-6062

Statistical analysis, approval of the final version of the original, design and planning of the study, preparation and writing of the original, data collection, analysis and interpretation, active participation in mentoring the research, intellectual participation in propaedeutics and/or therapeutics of the cases studied, critical review of the literature, critical review of the original.

Alexandre de Almeida Filippo | ORCID 0000-0001-9550-5156

Statistical analysis, approval of the final version of the original, design and planning of the study, preparation and writing of the original, data collection, analysis and interpretation, active participation in mentoring the research, intellectual participation in propaedeutics and/or therapeutics of the cases studied, critical review of the literature, critical review of the original.

Manuela da Silva | ORCID 000-003-4419-5722

Preparation and writing of the original.

REFERENCES

1. Miller CS, Foulke CN. Use of lysine in treating recurrent oral herpes simplex infections. Gen Dent. 1984; 32(6):490-3.

2. Corey, L., 2005. Herpes simplex virus. In: Mandell, G.L., Bennett, J.E., Dolan, R. (Eds.), Mandell’s Principles and Practice of Infectious Diseases, sixth ed. Churchill Livingstone, New York, pp. 1762-1780.

3. Griffith RS, Norins AL, Kagan C. A multicentered study of lysine therapy in Herpes simplex infection. Dermatologica. 1978;156(5):257-67.

4. Gilbert S; Improving the outcome of facial resurfacing-prevention of herpes simplex virus type 1 reactivation, J Antimic Chemother. 2001; 47(suppl T1): 29-34.

5. Wall SH., Ramey SJ, Wall F. Famciclovir as antiviral prophylaxis in laser resurfacing procedures. Plast Reconstr Surg. 1999; 104(4):1103-8.

6. Buthani T., Batra SR, Dermatologia Cosmética, 1 edição, Rio de Janeiro, Elsevier Editora, 2009. Dispositivos ablativos, cap 7, pp 238-242

7. Griffith RS, Walsh DE, Myrmel KH, Thompson RW, Behforooz A. Success of L-lysine therapy in frequently recurrent herpes simplex infection. Treatment and prophylaxis. Dermatologica. 1987; 175(4):183-90.

8. McCune MA, Perry HO, Muller SA, O’Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis. 1984; 34(4):366-73.

9. Pedrazini MC, Cury PR, Araújo VC, Wassall T. Efeito da lisina na incidência e duração das lesões de herpes labial recorrente. RGO. 2007; 55(1): 7-10.

10. Nanni CA, Alster TS. Complications of carbon dioxide laser resurfacing: an evaluation of 500 pts. Dermatol Surg. 1998; 24(3):315-20.

11. Naouri M, Delage M, Khallouf R, Georgesco G, Atlan M. CO2 fractional resurfacing: Side effects and immediate complications. Ann Dermatol Venereol. 2011; 138(1):7-10.

12. Cohen SR, Goodacre A, Lim S, Johnston J, Henssler C, Jeffers B, et al. Clinical Outcomes and Complications Associated with Fractional Lasers: A Review of 730 Patients. Aesthetic Plast Surg. 2017;41(1):171-78.

13. Gilbert S, McBurney E. Use of valacyclovir for herpes simplex virus-1 (HSV-1) prophylaxis after facial resurfacing: A randomized clinical trial of dosing regimens. Dermatol Surg. 2000; 26(1):50-4.

90,000 NOW L-Lysine 500 mg 100 cap.

Lysine is an essential amino acid that helps with genital herpes and herpes of the lips. It is an integral part in the formation of protein.

Lysine:

prevents herpes;
antioxidant;
fights migraines.

L-Lysine is the best drug that fights the herpes virus. When lysine enters the body, it replaces the amino acid arginine.If you look at the chemical structure, they are very similar. Therefore, the herpes virus makes a mistake and builds new viruses from lysine, and not from a similar amino acid – arginine. Therefore, the new viruses that have appeared, obtained from Lysin, immediately die and their spread stops. It is also scientifically proven that lysine fights migraines and has an antidepressant effect. Stress is one of the main causes of genital herpes. The increased level of steroid hormones under stress leads to the fact that the supply of l-lysine in our body is drastically consumed and depleted.On its basis, antibodies are created that protect the body. When the level of protective cells decreases, then this leads to a subsequent relapse. The relapse itself is even more stressful: you will not be able to live a normal sex life, the genitals will itch, you will quarrel with loved ones, you will not cope with prof. responsibilities, etc.
This amino acid does not cause drowsiness, does not reduce concentration and performance, mental or physical dependence. After consuming lysine, you will be able to drive a car.If it is not enough in the body, it can cause fatigue, dizziness, nervousness and much more. If you use this drug for a long time, then it accumulates in the body without causing toxic effects, and is used as energy storage. Excess comes out in the urine.

L-Lysine:
is an antiherpetic drug
is an antidepressant that fights stress – the main cause of herpes recurrence.
Lysine is found in dairy products, yogurt, fish, pork, cheese, meat protein, egg white, soy, potatoes, wheat, and lentils.

Used for:
increase in muscle volume;
increasing muscle strength;
increasing female libido;
improving erectile function in men;
improving short-term memory;
preventing the development of atherosclerosis;
preventing recurrence of genital herpes;
preventing the formation of “colds on the lips”;
thickening of the hair;
growth retardation of the fetus or newborn;
increasing calcium accumulation.
prevent osteoporosis.

MANUFACTURER:

USA.

BAA “L-Lysine monohydrochloride” (Nutricare, Argo)

Lysine is an essential amino acid that is part of almost any protein, it is found in meat, fish, potatoes, yeast and eggs and plays the role of a building material for all proteins, promotes the growth and restoration of collagen, participates in the production of antibodies, hormones and enzymes.Lack of lysine adversely affects protein synthesis, which leads to increased fatigue, poor appetite, weight loss, irritability, blurred vision, baldness, decreased libido and potency. With a deficiency of lysine in the body, the growth rate of children slows down, and early gray hair appears in adults.

Action : stimulating, rejuvenating, antiviral, regenerating, antidepressant, tonic.

Lysine stimulates the immune system, makes a person more resistant to diseases and helps to cope with existing diseases, has an effective antiviral effect against herpes and acute respiratory infections, which makes it indispensable for immunodeficiency states.The mechanism of the antiherpetic action of lysine is interesting: after penetration into the body, herpes viruses begin to multiply, the main building material for the construction of new viruses is the amino acid arginine, which is similar in structure to L-lysine. When L-lysine is injected into the body, the “deceived” herpes viruses begin to use it instead of Arginine, the newly formed viruses die and reproduction stops.

L-lysine improves the secretion of important hormones of a protein nature – hormones of the thyroid gland, pancreas, pituitary gland, stimulates the active synthesis of growth hormone, accelerates the breakdown of fats and promotes weight loss.Athletes use L-Lysine for muscle building, sports injury recovery, and fatigue and overtraining.

It has been proven that lysine has a mild antidepressant effect, stimulates mental performance, increases energy potential, relieves migraine-type headaches, increases libido and stabilizes erectile function in men. Lysine lowers low-density cholesterol, is a precursor of the amino acid carnitine, which is essential for heart health, and maintains the health of the cardiovascular system in coronary heart disease and diabetes mellitus, it also improves the absorption of calcium from the blood and its transport to bone tissue, therefore it is successfully used for prevention and the treatment of osteoporosis.Lysine also improves vision, prevents cataracts and other degenerative processes in the tissues of the eye.

Readings:

• Immunodeficiency conditions (viral and infectious diseases, hepatitis, herpes types 1 and 2),
• Cardiovascular diseases (ischemic heart disease, atherosclerosis),
• Nervous disorders (depression, anxiety, neurosis, frequent stress),
• Prevention of premature aging (osteoporosis, baldness, cataracts, decreased libido and potency, recovery from illness),
• Endocrine disorders (diabetes mellitus, prediabetes, hypothyroidism, obesity),
• Chronic fatigue syndrome (weakness, lethargy, apathy),
• Sports activities (high loads, fatigue).

Contraindications : individual intolerance to the components, pregnancy, breastfeeding. It is recommended to consult a doctor before use.

Instructions for use L-Lysine:

Adults take 2 tablets with meals 1 time per day with water. Duration of admission is 4-6 weeks with a break of 2 weeks. Compatible with dietary supplements Shark cartilage

Composition : L-lysine hydrochloride (L-lysine – 400.2 mg) 500 mg. Auxiliary components: carrier: microcrystalline cellulose (E460i) -82.5, stabilizer: stearic acid (E570) -45, stabilizer, baking powder, anti-caking agent, water-retaining agent: dicalcium phosphate (E341ii) -18.5, anti-caking additive and clumping: magnesium stearate – magnesium salt of fatty acids (E470b) -4.

Product form: tablets weighing 650 mg, 60 tablets in a plastic jar.

Shelf life – 2 years

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90,000 L-Lysine 500mg from Nutricare

L-lysine actively fights against viruses that cause herpes and acute respiratory infections.It helps to lengthen the recurrence gap in various types of herpes (including genital). Long-term and regular use of L-lysine has a mild antidepressant effect. In addition, the amino acid is recommended for people consuming low-calorie or insufficiently rich foods in protein.

L-lysine has antiviral effect, especially against viruses that cause herpes and acute respiratory infections. It is recommended to combine lysine with vitamin C for viral diseases.In the United States of America and some European countries, lysine-based dietary supplements are used to prevent frequently recurrent forms of genital herpes. Several decades ago, it was noticed that some people suffering from herpes, but following a certain diet, relapse less often.

Mechanism of action of lysine on the herpes virus

As soon as the herpes virus enters the body, it begins to multiply actively. For this, it needs particles of cells in our body, and the amino acid arginine is the main building material for new viruses.Once in the body, lysine simply replaces arginine. In terms of their chemical properties and structure, these two amino acids are identical. The herpes virus cannot distinguish them from each other, so it begins to grow new viruses not from arginine, but from lysine. Such “newborn” viruses die very quickly, and reproduction is suspended, since lysine is not suitable for them as a building material.

As you know, stress is one of the main causes of recurrence of genital herpes.The increase in the level of steroid hormones during stress leads to a sharp consumption and depletion of lysine reserves in the body. On the basis of lysine, protective antibodies and other important cells of the immune system are built. A decrease in the level of protective cells leads to another strong relapse. The relapse itself is even more stressful for the nervous system and the body: you cannot live a normal sex life, your genitals itch and sore, you quarrel with loved ones, do not cope with professional duties, etc.Therefore, in order to prevent relapses and similar situations, you need to consume sufficient amounts of lysine.

For tissue repair and shaping

Lysine is a component of almost every protein in the human body. This means that it is simply irreplaceable in the synthesis of muscle fibers and the formation of full-fledged muscle tissue, because it is known how much protein it contains.

Lysine can be recommended for people who want to gain muscle mass, for example, bodybuilders.In this case, it is simply irreplaceable. Lysine is involved in collagen formation and tissue repair. It is used in the recovery period after surgery and sports injuries.

Lysine is a powerful source of energy, as it accelerates the breakdown of fats, which are an effective “fuel” for the body. With prolonged consumption, lysine does not accumulate and does not have a toxic effect on the human body. The excess is excreted by the kidneys in the urine.

Scientific experiments have shown that with prolonged use, lysine has a mild antidepressant effect, and while taking lysine, some people have gone away from headaches and migraines that torment them.Lysine does not cause drowsiness, decreased concentration and performance, mental or physical dependence. After taking lysine, you can safely drive a car.

On the contrary, a lack of lysine in the diet can be the cause of increased fatigue, nausea, dizziness, lethargy, decreased appetite, nervousness, the appearance of blood vessels on the white membrane of the eye (symptom of “red eyes”), menstrual dysfunction.

Lysine in combination with proline and vitamin C prevents the formation of lipoproteins that cause blockage of the arteries, therefore, it will be useful in cardiovascular pathologies.

This essential amino acid improves the absorption of calcium from the blood and its transport to the bone tissue, so it can be an integral part of the program for the treatment and prevention of osteoporosis.

Main properties of L-Lysine:

• prevents recurrence of herpes;
• increases muscle strength and endurance;
• helps to increase muscle volume;
• improves short-term memory;
• enhances female libido;
• improves erection;
• prevents the development of atherosclerosis;
• prevents the development of osteoporosis;
• improves hair structure.

BAA is not a medicine.

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90,000 L-lysine.Publications 1998 – 2014

13713

In the United States of America and some European countries, dietary supplements based on L – lysine are used to prevent frequently recurrent forms of genital herpes. Several decades ago, people noticed that some fellow tribesmen suffering from herpes, but following a certain diet, had less relapses.The true reason for this phenomenon was understood only at the end of the 20th century, when amino acids were discovered and studied. It turned out that lysine contributes to the lengthening of the recurrence interval for herpes on the lips and genital herpes.

So what is this substance?

Lysine / Ch3 (Nh3) (Ch3) 3CH (Nh3) COOH / is an aliphatic amino acid with pronounced base properties. An essential amino acid. It is the basis for the formation of protein.

Synthetic lysine is used for the preparation of animal feed and food products.

Mechanism of action: After entering the body or at the time of the onset of relapse, the herpes virus type I or II begins to replicate (multiply). The virus uses parts of the cell to assemble new particles. The main building blocks for the construction of a new virus is the amino acid ARGININE. When L-LYSINE is introduced into the diet, which is similar to ARGININE in chemical structure like a twin brother, it (lysine) accumulates in excess amounts in the cell. The herpes virus “makes a mistake” and begins to build new viruses not from ARGIN, but from LYSIN, which can be figuratively compared with the construction of houses from concrete (building material ARGININ) and sand (LYSIN).Naturally, “newborn” viruses, built from LYSIN, immediately die, reproduction stops. The key enzyme in the destruction of the virus is L-lysine-alpha-oxidase.
It is known that under severe stress the lysine stores in the cell are quickly depleted, and the virus “rears its head”. Therefore, people who are often nervous or take everything to heart more often than others are exposed to herpes attacks.

Natural sources of lysine:
– Dairy products, yoghurt (casein and lactalbumin)
– Fish
– Pork
– Cheese
– Meat protein
– Egg white
– Soy
– Potato
– Wheat germ
– Lentil

Biological effects of lysine:
1.Anabolic, increases muscle volume;
2. Increases muscle strength;
3. Increases female libido;
4. Improves erectile function in men;
5. Improves short-term memory;
6. Prevents the development of atherosclerosis;
7. Prevents recurrence of genital herpes;
9. Prevents the formation of “colds on the lips”;
10. Thickens hair;
11. Inhibits the growth of the fetus or newborn (proven in animal embryos).
12. Increases the accumulation of calcium in the body.Prevents the development of osteoporosis (bone loss).

Treatment:
L-Lysine has been studied in no less than 4 interclinical studies conducted around the world. The most objective results were obtained at the Mayo Clinic (Mayo is a large clinical center in the USA, six 22-storey clinics). Doctors McCume M., Perry H., Muller S., and O’Fallon W. found that ingestion of 1248 mg of lysine 1 time per day leads to a 2.4-fold reduction in the recurrence of herpes.

Pregnancy:
During pregnancy, it is better to refrain from using lysine.Since there is evidence that the drug inhibits the growth of the fetus.

Use in children:
Children are better off refraining from taking L-lysine, as animal studies have shown that elevated concentrations can inhibit growth.

Dose:
– To increase the relapse-free period of herpes infection – 1250 mg daily on an empty stomach (2.5 tablets of 500 mg) or 1.5 tablets of 1000 mg
– To stop relapse, under the supervision and as prescribed by a doctor – 2000 – 4000 mg / day.

For greater effectiveness of treatment, seeds, chocolate, all types of nuts should be excluded from the diet.

Where to buy:
Unfortunately, not all food supplements based on L-Lysine, sold in Russia, such as Aviton Lysin-Active, Lysivit C, Yeast with Lysine, are suitable for the treatment of herpes, because. , firstly, they contain a very small amount of lysine (300 mg per tablet). Let me remind you that you need to take at least 1250 mg per day in the relapse-free period and 2000 – 4000 mg during a relapse.Second, the lysine-based dietary supplements sold in sports nutrition stores contain the wrong lysine: there are two stereoisomers of lysine: right-handed and levogyrate. For the prevention of genital herpes, only the levorotatory isomer or L-Lysine is suitable.

Lysine is registered as a food supplement, and its medicinal properties are being studied by science. Perhaps, over time, new drugs will be created on the basis of L-lysine for the effective treatment of herpes.

Kokotkin Ivan Yurievich, doctor

90,000 L-lysine application, beneficial properties and contraindications.For sports and health.

For the normal functioning of the body, vitamins, nutrients are required, and these are not only vitamins and minerals, but also biologically active compounds. Most of them are synthesized by the body, and some come from the outside, along with food. These include lysine, which belongs to amino acids, is included in the structure of proteins in the human body.

The main source of the essential amino acid L-Lysine is food products, including fish, meat, milk, vegetables, fruits, soybeans.The use of these products will help to ensure the smooth functioning of internal organs and systems. What is the use of the supplement, how to take it, and what are the consequences of its deficiency?

Useful properties of lysine

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L-Lysine (lysine) – an essential amino acid (protein) that the body cannot produce on its own, it gets only from food. The additive acts as the basis of protein compounds, participates in many body processes:

• increases the density of connective and bone tissue
• Accelerates recovery from injuries and operations
• normalizes blood cholesterol levels
• enhances immune defense, protects against viruses, fungi and bacteria
• maintains nitrogen balance
• promotes the absorption of calcium
• reduces the risk of developing cardiovascular pathologies
• helps build muscle
• strengthens nails, hair
• stimulates collagen production
• increases stamina
• normalizes fat metabolism

L-lysine is an important building material that benefits humans, is also indispensable for athletes, accelerates muscle gain, and provides energy.

If an insufficient amount of an amino acid enters the body, this leads to the development of a number of disorders: increased fatigue, decreased appetite, impaired potency, hair loss, growth retardation in children. Imbalance affects the functioning of the whole organism, increasing the risk of pathological changes in the immune, cardiovascular, musculoskeletal and digestive systems. To eliminate such consequences for the body, it is important to ensure proper and nutritious nutrition, or to take L-lysine in the form of dietary supplements, which are provided in a wide range, allow you to provide the daily requirement of the amino acid in the body.

IMPORTANT !!!
Before taking a dietary supplement, it is important to study the instructions for use and consult a doctor. This article on hvastik.com is informational, intended to broaden the general horizons, can not serve as a prescription for treatment and does not replace the consultation of a doctor in any way. We warned you!

Lysine for immunity

The amino acid lysine has the ability to stimulate the production of neutrophils, which are essential for the proper functioning of the immune system.According to the results of studies carried out on animals, L-Lysine deficiency leads to immunodeficiency conditions, increases the risk of developing viral and bacterial infections.

The additive has the ability to increase the number of lymphocytes, improves the globulin fraction of the blood protein, thereby having a pronounced immune-correcting (improving immunity) effect.

Lysine increases the body’s defenses, enhances the production of interferon. It is recommended to include it in the program of comprehensive rehabilitation with an increased risk of viral infections.This substance is used in complex therapy against the herpes virus, reduces the risk of developing diseases of the respiratory and genitourinary system.

Lysine in cardiology

The amino acid lysine brings benefits in diseases of the heart and blood vessels. It is known that 80% of such pathologies are associated with an increased level of cholesterol in the blood, which contributes to the development of vascular atherosclerosis. The German scientist and doctor conducted a number of clinical trials that proved that taking lysine supplements together with vitamins, macro- and microelements can reduce the risk of atherosclerosis by 50%, which acts as a trigger for the development of stroke and heart attack.

Studies have shown that lysine blocks the action of lipoproteins, which are classified as complex protein-fat complexes that are part of all living organisms. The supplement eliminates the formation of lipoproteins that cause blockage of the arteries, normalizes blood pressure levels, and stabilizes the heart rate.

Lysine for sports

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Lysine is widely used in amateur and professional sports.The amino acid helps to recover faster after exercise, has a corrective effect, and takes part in building muscle tissue and muscles.

Taking lysine allows:

1. reduces the likelihood of sports injuries
2. restores ligaments and muscles after strength loads
3. strengthens the cartilage and bone system
4. stimulates the production and assimilation of complete protein
5. sells clear contours to the figure.

Lysine is especially popular among bodybuilders.The additive is added to sports nutrition, protein shakes are prepared on its basis or taken as capsules for oral administration.

What else is the additive used for?

In medicine, the amino acid lysine is not used as a medicine, but its effectiveness has been proven in many biological processes. The supplement helps in solving the following health problems:

• accelerates recovery from injuries and operations
• promotes rapid resorption of hematoma
• reduces the risk of developing pathologies of the heart and blood vessels
• is an excellent anti-cancer agent
• strengthens bone tissue, reduces the development of osteoporosis
• slows down the process of destruction of the tissue of the lens of the eye
• participates in the formation of collagen
• lowers blood sugar
• helps in the treatment of herpes

The supplement is unable to replace the intake of pharmaceutical medicines in the treatment of certain diseases, but its use will reduce the risks of their complications.Lysine is involved in almost all processes of the body, therefore it is very important that it enters the body every day, and it does not matter in what form – food or food additives.

Application and dosage of L-lysine

The daily intake of L-Lysine depends on age, gender, degree of physical activity, on average 23 mg / kg per day. Men who are involved in active sports are recommended to take 30-50% more.

Dosage 500 mg L-Lysine Supplement from Now Foods

The recommended dosage is 800-3000 mg per day.It is recommended to take the supplement immediately after waking up, before training, or after physical exertion. The supplement is contraindicated for children under 12 years of age. Adults take 1 capsule 3-4 times a day.

In sports supplements, the amino acid is in the form of hydrochloride, a soluble salt of hydrochloric acid. After entering the body, the salt breaks down with the release of lysine, which is well absorbed by the body.

L-lysine escinate in medicine

The drug L-lysine escinate solution for injection 1 mg / ml, 5 ml is provided on the pharmaceutical market.It belongs to the group of vasoprotectors, it is used as part of the complex therapy of cerebral edema of various origins. It has a pronounced anti-inflammatory, decongestant and analgesic effect.

L-lysine escinate does not belong to dietary supplements, it is a registered drug , which is dispensed in a pharmacy, is often used in a hospital setting, and is prescribed only by a doctor strictly according to indications.

Side and contraindications

L-lysine supplements are safe products, but in order to get the maximum effect from the intake, it is important to strictly adhere to the recommended doses, study the instructions, and, if possible, consult a doctor.Side effects from taking are observed rarely and only if the composition of the supplement is intolerant or the dosage is exceeded.

Review of side effects to L-Lysine from Now Foods on Iherb

You can recognize side effects after taking a dietary supplement by the following symptoms:

• Stool disorder: diarrhea, flatulence
• nausea, retching
• discomfort, abdominal pain

Lysine is completely safe for use, but supplements have some contraindications, including:

• pregnancy, lactation
• individual intolerance to the composition of a specific dietary supplement with lysine
• severe pathologies of the liver, kidneys

90,059 children under 12 years old

L-lysine increases the absorption of calcium , therefore, care must be taken when taking supplements and calcium supplements at the same time.Prolonged and uncontrolled intake of the amino acid in the form of a dietary supplement increases the risk of gallstones and may impair liver function.

Table of applicability of drugs with L-lysine

• Herpes
  1 to 3 grams daily
  Supplementing with lysine may reduce recurrences by suppressing the virus that causes sores.
• Genital herpes
  1000 mg / day
  Taking lysine may speed healing and help prevent future outbreaks.
• Postherpetic neuralgia
  On the recommendation of a doctor
  Because shingles is caused by a herpes virus, some doctors believe that lysine could help, since it inhibits replication of herpes simplex, a related virus.

Background: green – scientifically proven, orange – insufficient evidence, White – no research

Most Popular Zinc Supplements

Conclusion

The effectiveness of the amino acid L-lysine has been proven by numerous clinical studies that have been conducted in different countries of the world.Preparations with its content are often recommended by doctors as a prophylactic agent or as part of complex therapy. You can buy lysine supplements at online pharmacies or sports nutrition stores.

But before taking them, it is imperative to study the instructions, if possible, consult a doctor. The doctors’ comments on drugs with lysine are positive. The supplement is popular among athletes and people who care about their health and lead an active lifestyle.

.