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What is a bad creatinine level: Symptoms, Signs, Stages & Diet

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Symptoms, Signs, Stages & Diet

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Sources:

National Institute of Diabetes and Digestive and Kidney Diseases. Your Kidneys and How They Work.
<https://www.niddk.nih.gov/health-information/health-topics/Anatomy/kidneys-how-they-work/Pages/anatomy.aspx>

NIH: The Kidneys and How They Work
<http://kidney.niddk.nih.gov/Kudiseases/pubs/yourkidneys/#kidneys>

National Kidney Foundation. 10 Signs You May Have Kidney Disease.
<https://www.kidney.org/news/ekidney/august14/10_Signs_You_May_Have_Kidney_Disease>

National Institute of Diabetes and Digestive and Kidney Disease. Kidney Failure: Choosing a Treatment That’s Right for You.
<https://www.niddk.nih.gov/health-information/health-topics/kidney-disease/kidney-failure-choosing-a-treatment-thats-right-for-you/Pages/facts.aspx>

The Renal Association. CKD Stages.
<http://www.renal.org/information-resources/the-uk-eckd-guide/ckd-stages>

NIH. Eat Right to Feel Right on Hemodialysis.
<http://kidney.niddk.nih.gov/Kudiseases/pubs/eatright/>

NIH: Acute Kidney Failure
<http://www.nlm.nih.gov/medlineplus/ency/article/000501.htm>

NIH: Kidney Disease of Diabetes
<http://kidney.niddk.nih.gov/Kudiseases/pubs/eatright/>

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Creatinine tests – Mayo Clinic

Overview

A creatinine test is a measure of how well your kidneys are performing their job of filtering waste from your blood.

Creatinine is a chemical compound left over from energy-producing processes in your muscles. Healthy kidneys filter creatinine out of the blood. Creatinine exits your body as a waste product in urine.

A measurement of creatinine in your blood or urine provides clues to help your doctor determine how well the kidneys are working.

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Why it’s done

Your doctor or other health care provider may order a creatinine test for the following reasons:

  • To make a diagnosis if you have signs or symptoms of kidney disease
  • To screen for kidney disease if you have diabetes, high blood pressure or other conditions that increase the risk of kidney disease
  • To monitor kidney disease treatment or progression
  • To monitor for side effects of drugs that may include kidney damage or altered kidney function
  • To monitor the function of a transplanted kidney

How you prepare

A standard blood test is used to measure creatinine levels in your blood (serum creatinine). Your doctor may ask you not to eat (fast) overnight before the test.

For a creatinine urine test, you may need to collect urine over 24 hours in containers provided by the clinic.

For either test, you may need to avoid eating meat for a certain period before the test. If you take a creatine supplement, you’ll likely need to stop use.

What you can expect

For a serum creatinine test, a member of your health care team takes a blood sample by inserting a needle into a vein in your arm.

For a urine test, you’ll need to provide a single sample in the clinic or collect samples at home over 24 hours and return them to the clinic.

Results

Results from creatinine in blood or urine are measured and interpreted in many ways, including the following:

Serum creatinine level

Creatinine usually enters your bloodstream and is filtered from the bloodstream at a generally constant rate. The amount of creatinine in your blood should be relatively stable. An increased level of creatinine may be a sign of poor kidney function.

Serum creatinine is reported as milligrams of creatinine to a deciliter of blood (mg/dL) or micromoles of creatinine to a liter of blood (micromoles/L). The typical range for serum creatinine is:

  • For adult men, 0.74 to 1.35 mg/dL (65.4 to 119.3 micromoles/L)
  • For adult women, 0.59 to 1.04 mg/dL (52.2 to 91.9 micromoles/L)

Glomerular filtration rate (GFR)

The measure of serum creatinine may also be used to estimate how quickly the kidneys filter blood (glomerular filtration rate). Because of variability in serum creatinine from one person to another, the GFR may provide a more accurate reading on kidney function.

The formula for calculating GFR takes into account the serum creatinine count and other factors, such as age and sex. A GFR score below 60 suggests kidney disease. The range of scores below 60 may be used to monitor treatment and disease progression.

Creatinine clearance

Creatinine clearance is a measure of how well the kidneys filter creatinine out of the bloodstream for excretion in urine.

Creatinine clearance is usually determined from a measurement of creatinine in a 24-hour urine sample and from a serum sample taken during the same time period. However, shorter time periods for urine samples may be used. Accurate timing and collection of the urine sample is important.

Creatinine clearance is reported as milliliters of creatinine per minute per body surface area (mL/min/BSA). The typical range for men, 19 to 75 years old, is 77 to 160 mL/min/BSA.

The typical range, by age, for creatinine clearance in women is as follows:

  • 18 to 29 years: 78 to 161 mL/min/BSA
  • 30 to 39 years: 72 to 154 mL/min/BSA
  • 40 to 49 years: 67 to 146 mL/min/BSA
  • 50 to 59 years: 62 to 139 mL/min/BSA
  • 60 to 72 years: 56- to 131 mL/min/BSA

Standard measures have not been determined for older adults.

Results lower than the typical range for your age group may be a sign of poor kidney function or conditions that affect blood flow to your kidneys.

Albumin/creatinine ratio

Another interpretation of urine creatinine count is called the albumin/creatinine ratio. Albumin is a protein in blood. Healthy kidneys generally don’t filter it out of the blood, so there should be little to no albumin found in the urine.

Albumin/creatinine ratio describes how much albumin is in a urine sample relative to how much creatinine there is. The results are reported as the number of milligrams (mg) of albumin for every gram (g) of creatinine. Results indicating a healthy kidney are:

  • For adult men, less than 17 mg/g
  • For adult women, less than 25 mg/g

A higher than typical result may be a sign of kidney disease. In particular, the result may indicate a complication of diabetes called diabetic nephropathy, or diabetic kidney disease.

Your doctor or other health care provider will discuss the results of a creatinine test with you and help you understand what the information means for a diagnosis or treatment plan.


Feb. 25, 2021

Test, Range & Symptoms of High Creatinine

Overview

What is the creatinine clearance test?

The creatinine clearance test is an older test used to check your kidney function. This test allows your healthcare provider to look at samples of your urine and blood to see how much of the waste product — creatinine — is filtered out by your kidneys. Abnormal levels of creatinine in your urine and blood could point to an issue like kidney disease.

Done in two parts, the creatinine clearance test involves collecting your urine over a 24-hour period of time and then having your blood drawn. These samples are then tested to see how much creatinine was filtered through your kidneys over the 24-hour window. The results of the test will be used in a mathematic formula that figures out your creatinine clearance. Creatinine clearance is one way to estimate your glomerular filtration rate (GFR), or how well the kidneys are filtering your blood. The GFR is the main number used by your provider to determine how well your kidneys are working.

The creatinine clearance test is not used very often any more. It has largely been replaced by the estimated GFR (eGFR) equations using creatinine levels in the blood — which means a 24-hour urine collection is not needed.

What is creatinine?

Creatinine is actually a waste product of creatine. Creatine is a chemical that your body uses to supply your muscles with energy. As you muscles use energy the tissue that makes up your muscles breaks down. This natural breakdown of muscle tissue causes creatinine to be released into your bloodstream. This is when creatine becomes creatinine.

Normally, creatinine is filtered out of your blood by your kidneys. If you think of each organ in your body as having a job, the kidneys are the filters. They’re responsible for cleaning your blood. The material that’s removed from your blood leaves your body in your urine. If your kidneys aren’t working properly, than you may have higher levels of creatinine in your blood than you should.

Why do I need to have the creatinine clearance test?

Anyone can be at risk for a kidney disease at some point in their life. However, some people have a higher risk of developing a kidney problem than others. These risks can include:

  • Age (you could be at a higher risk after age 60).
  • Diabetes.
  • High blood pressure (hypertension).
  • Family history of kidney disorders.
  • Heritage (there’s a higher risk for people of an African-American, Asian, Native American or Pacific Islander background).

When is the creatinine clearance test done?

The creatinine clearance test is done when your healthcare provider thinks that the eGFR result given with your blood creatinine level may not be accurate. Examples includes when people have very little or a lot of muscle on their bodies. However, there are ways to check this, such as with the eGFR result using cystatin C, another blood test. As a result, creatinine clearance is rarely used in modern practice.

Are there any symptoms associated with a high creatinine level?

Kidney disease tends to be silent and, for many people, there are no symptoms in the early stages. However, as the disease progresses, you may experience a few symptoms. These can include:

  • Swelling.
  • Fatigue (feeling tired).
  • Changes in how often you urinate.
  • Loss of appetite.
  • Nausea.
  • Itching.

Why is the creatinine clearance test done?

The creatinine clearance test is to confirm the level of kidney function reported with the eGFR level. Your healthcare provider will want to know how well your kidneys are working. The results of this test can lead to a diagnosis of kidney disease.

Test Details

Is the creatinine clearance test done at home?

Part of the creatinine clearance test is done at home and the other part in a lab. You will collect your urine over a 24-hour period of time at home. During this time, you can still participate in your normal daily activities. You just need to stick to a schedule for collecting your urine samples and make sure not to miss any collections (do not flush any urine).

The second part of the test involves having your blood drawn. This will need to be done at a lab, healthcare facility or your provider’s office. Your provider will give you directions on where to go to for the blood test when you pick up your test materials. Often, you will drop off your urine collection when you go to get your blood drawn.

What do I need to do to prepare for the creatinine clearance test?

Before the creatinine clearance test, your healthcare provider will give you specific instructions. During the creatinine clearance test you will need to collect your urine for 24 hours and then your blood will be drawn.

Your provider will provide the container you will need to collect your urine sample and will tell you how to store it over the 24-hour period when you’re collecting it. It’s important to follow the instructions your provider gives you. Make sure you collect urine throughout the test. If you skip a few times or don’t follow the instructions, you may need to repeat the test.

You may also be asked to stop taking some medications. This will be done with your provider’s direct supervision. Some medications could affect the test’s accuracy, and so you might need to temporarily stop taking them. These medications could include:

  • Antibiotics (Bactrim).
  • Stomach acid pills (such as famotidine).

Make sure to let your provider know about any medication you are taking and make sure there is a complete list of all medications you are taking in your medical record. Never stop any medication without first talking to your healthcare provider.

Do I need to fast (not eat) before the creatinine clearance test?

In general, you can eat normally before and during the creatinine clearance test. However, you may be asked not to eat overnight. Your provider may also ask you not to eat meat before the test. This could change the results because there’s higher levels of creatine in meat, which would cause your body to have higher levels of creatinine during the test.

What happens during the creatinine clearance test?

You will do the creatinine clearance test over 24 hours. During this time, you will collect your urine each time you urinate. This will give your healthcare provider a good idea of your creatinine levels throughout the entire day.

Make sure to follow the directions from your healthcare provider closely. These instructions will include details about how to store your urine sample and where you will take it when the test is over.

After 24 hours of collecting your urine, you will need to have your blood drawn. This second part of the test looks at the amount of creatinine in your bloodstream. This is called serum creatinine. Your results from both of these tests will be plugged into a mathematic formula that determines your creatinine clearance. This rate tells your provider just how well your kidneys are filtering waste products out of your bloodstream.

What happens if I forget to collect one urine sample during collection?

It’s very important to collect urine samples throughout the entire day for the creatinine clearance test to be accurate. If you skip one urine collection, it could affect the test results. Call your healthcare provider’s office if you miss a collection to see if you should continue the test or stop and start over the next day.

Will I feel any pain during the creatinine clearance test?

The creatinine clearance test is generally painless. The first part of the test involves normal urination over a 24-hour period of time. You might experience some discomfort from the needle when you have your blood drawn. This is a necessary part of the test and happens quickly. Some people describe having their blood drawn as a stinging feeling. It’s possible to feel some throbbing or have a slight bruise after having your blood drawn. However, all of this discomfort goes away quickly.

Results and Follow-Up

Can the creatinine clearance test be wrong?

The creatinine clearance test is generally a reliable test. Creatinine clearance is only an estimate of GFR, and in some cases can provide a result that is higher than what your GFR really is. In addition, there are a few reasons that the results could be wrong. These include:

  • If you didn’t collect all urine samples as directed.
  • If the math formula used to figure out your creatinine clearance isn’t done correctly.

Blood test, normal range, and how to lower levels

You’re on mile two of your afternoon run, or powering through a third set on the bench, or biking uphill on your daily commute. You’re breathing fast, and your muscles are on fire. Sweat drips off your chin. Heat flushes your cheeks. And when you’re done, nothing feels better than a warm shower, a cold glass of water, and a seat on the couch.

Like most people, you’re acutely aware of how physical activity makes your body feel—the breathing, sweat, and heat. You might even thrive on it. But there’s a whole lot more going on under the surface. When your muscles break down during exercise, they slowly build back up, increasing muscle mass, but this process also releases waste products into your blood, primarily creatinine. 

While it might be the last thing you think about while you’re timing your miles or hitting a one-rep max, your blood creatinine levels can be a key indicator of your renal health and kidney function. 

What is creatinine?

Everyone has certain serum creatinine levels in their bloodstream. Creatinine is a natural byproduct of muscle use, caused by the breakdown of a chemical called creatine. Creatinine itself doesn’t have a specific physiological function—it’s just a waste product. It simply stays in the blood until reaching the kidneys, where it’s filtered and eliminated through urination.  

So, how does your body generate creatinine? It starts with creatine, which is synthesized in the kidneys, pancreas, and liver, then transported via blood flow and stored in your skeletal muscles. During exertion, your muscles convert creatine to energy, which assists in muscle contraction. After serving its purpose, creatine becomes creatinine and re-enters the bloodstream en route to the kidneys. 

Even though creatinine doesn’t actively benefit (or harm) your body, the amount of creatinine in your blood can be measured to evaluate your kidney health. For this reason, physicians will often use a creatinine test—along with other lab tests, like a blood urea nitrogen (BUN) test—to monitor for chronic kidney disease (CKD) or renal failure.

What is a good creatinine level?

In most cases, the normal range for serum creatinine (found in the blood) for someone with healthy kidneys is 0.9 to 1.3 mg per deciliter for adult males and 0.6 to 1.1 mg per deciliter for adult females.

However, there are a lot of variables when it comes to levels of creatinine. “Normal” is a somewhat subjective term. Muscle breakdown creates creatinine, so your muscle mass and activity level can influence the amount in your blood. To accurately measure blood creatinine levels, a doctor will first assess these various factors to establish a baseline, according to Taylor Graber, MD, an anesthesiologist and founder of ASAP IVs. “Creatinine level assessment starts with getting a demographic baseline to assess what ‘normal levels’ should be,” Dr. Graber says. “This depends on age, race, gender, and body size. Once these values are normalized, changes from this range can signify abnormalities of the kidney.”

Healthcare providers like to keep an eye on creatinine levels for various reasons. If you had or currently have kidney disease, kidney damage, diabetes, or another illness that affects your kidneys, or are taking a medication that could affect your kidneys, your healthcare provider might order regular creatinine measurement to monitor your renal function. The most common test methods are via blood and urine. 

Blood tests

Creatinine that comes from your blood is called serum creatinine, and it can be measured by administering a routine blood test. “When kidney function becomes impaired, less creatinine is able to be cleared, which results in a higher level of creatinine in the blood,” Dr. Graber explains. “While this test does not directly tell you how well the kidney is functioning, it can be followed over time for changes.” Healthcare providers can use this creatinine blood test (along with factors like age, sex, race, etc.) to calculate your glomerular filtration rate (GFR), which is vital in diagnosing kidney failure or chronic kidney disease. 

​Urine tests

The other most common way to test creatinine levels is through a 24-hour urine collection. Why 24 hours? Exercise, diet, and hydration can all affect creatinine, so your levels could fluctuate throughout the day. Therefore, your healthcare provider will need multiple urine samples to evaluate your creatinine clearance effectively. As you might imagine, this test involves collecting all of your urine over 24 hours, then delivering it to your healthcare provider. Based on the results, your healthcare provider can determine how well your kidneys are filtering creatinine into the urinary tract. 

Healthcare providers will order both tests to get a comprehensive look at your kidney function by comparing your estimated GFR (eGFR) with the amount of urine creatinine present. If your doctor suspects kidney disease or damage, he or she may also order a blood urea nitrogen (BUN) test to confirm their diagnosis. This test measures the amount of urea nitrogen—another type of waste filtered by the kidneys—in a blood sample.

What do abnormal creatinine levels mean?

So, you went to the doctor, did the tests, and the results are in: You have high creatinine levels. Now what? Step one—don’t panic. Elevated creatinine doesn’t necessarily mean your kidneys are in a downward spiral. Anything outside the normal range (0. 9 to 1.3 mg per deciliter for adult males and 0.6 to 1.1 mg per deciliter for adult females) may cause a healthcare provider to investigate further, but doesn’t always spell danger. Numerous factors can influence your test results. Here are just a few:

  • Increased exercise: Have you been on a fitness kick? In the gym every day? This spike in muscle breakdown will increase the production of creatinine.
  • Increased protein consumption: Cooked meats contain creatinine, so if you’re feasting on steak and roast chicken every night, you could see higher levels. 
  • Urinary tract blockage: If you can’t urinate, your body can’t eliminate creatinine, so kidney stones and other urinary disruptions will allow it to remain in your bloodstream.
  • Certain medications: Sometimes, drugs can be the culprit. The antibiotic trimethoprim (find trimethoprim coupons | trimethoprim details) and Cimetidine (find Cimetidine coupons | Cimetidine details), a stomach ulcer and heartburn medication, can inhibit creatinine secretion. Sometimes, non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can also be a cause.
  • High blood pressure: Studies have also shown that hypertension, heart failure, and other heart conditions can cause increased creatinine levels.

Likewise, low creatinine isn’t always dangerous. It could be the result of low muscle mass (or a muscle disease like muscular dystrophy), pregnancy, a low-protein diet, or certain liver conditions. 

Can creatinine levels change quickly?

Creatinine levels can change rapidly, even throughout the day, which is why healthcare providers monitor them for an extended period of time. One blood test that returns high creatinine in blood could be a fluke. However, several tests in a row that show elevated levels could indicate chronic kidney disease. A sudden spike in creatinine levels could be a warning sign for acute kidney damage or other conditions, depending on symptoms. 

What is the connection between cancer and creatinine levels?

Abnormal creatinine levels could also indicate kidney or prostate cancer. Although, high or low creatinine on its own doesn’t necessarily mean you have cancer.

How to lower creatinine levels

How your healthcare provider treats your abnormal creatinine levels depends entirely on the underlying cause. Changes in lifestyle and diet can be a simple and effective treatment for minor cases. But chronic kidney disease, kidney damage, or kidney failure require more robust procedures. Medications to control symptoms, dialysis, or in the most extreme cases, a kidney transplant may be necessary. Here are a few potential methods for lowering creatinine levels:

What to do

  • Stay hydrated
  • Reduce protein intake
  • Reduce vigorous activity (but don’t cut out exercise altogether!)
  • Get more fiber in your diet (specifically from fruits and vegetables)

What to avoid

Natural remedies

Medications

There are no medications that specifically reduce the amount of creatinine in your blood. If a doctor determines kidney disease is causing abnormal creatinine levels, he or she might prescribe medication to alleviate symptoms. Prescription drugs include:

  • Angiotensin-converting enzyme (ACE) inhibitors like Lotensin (benazepril) and Capoten (captopril) to lower high blood pressure.
  • Angiotensin II Receptor Blockers (ARBs) like Edarbi (azilsartan) and Teveten (eprosartan) also treat high blood pressure and can reduce the amount of protein in your urine.
  • Erythropoiesis-stimulating agents (ESAs) to help increase your red blood cell count.
  • Phosphate or potassium binders to help eliminate extra phosphate and potassium that your kidneys can’t filter.

RELATED: Lotensin details | Captopril details

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In the end, the best medical advice for optimizing kidney function is living a consistently healthy lifestyle. Dr. Graber says: “Minimizing unhealthy foods high in processed ingredients, increasing fruit and vegetable intake, regular exercise (150 minutes of moderate-intensity or 75 minutes of vigorous-intensity aerobic exercise per week), staying hydrated, and maintaining body weight in a healthy range (body mass index of 20 to 25) are things to focus on over time to make sure you are giving the body the tools it needs to be successful.”

What to Expect with a Kidney Disease Diagnosis

Since you can have kidney disease without any symptoms, your doctor may first detect the condition through routine blood and urine tests.

The National Kidney Foundation recommends 3 simple tests to screen for kidney disease:

  1. Blood pressure measurement
  2. Spot check for protein or albumin in the urine (proteinuria) 
  3. Calculation of glomerular filtration rate (GFR) based on a serum creatinine measurement

Measuring urea nitrogen in the blood provides additional information.

Blood Pressure Measurement

High blood pressure can lead to kidney disease. It can also be a sign that your kidneys are already impaired. The only way to know whether your blood pressure is high is to have a health professional measure it with a blood pressure cuff.

The result is expressed as two numbers. The top number, which is called the systolic pressure, represents the pressure when your heart is beating. The bottom number, which is called the diastolic pressure, shows the pressure when your heart is resting between beats. Your blood pressure is considered normal if it stays below 120/80 (expressed as “120 over 80”).

The National Heart, Lung, and Blood Institute (NHLBI) recommends that people with kidney disease use whatever therapy is necessary, including lifestyle changes and medicines, to keep their blood pressure below 130/80.

Microalbuminuria and Proteinuria

Healthy kidneys take wastes out of the blood but leave protein. Impaired kidneys may fail to separate a blood protein called albumin from the wastes. At first, only small amounts of albumin may leak into the urine, a condition known as microalbuminuria, a sign of deteriorating kidney function.

As kidney function worsens, the amount of albumin and other proteins in the urine increases, and the condition is called proteinuria. Your doctor may test for protein using a dipstick in a small sample of your urine taken in the doctor’s office. The color of the dipstick indicates the presence or absence of proteinuria.

A more sensitive test for protein or albumin in the urine involves laboratory measurement and calculation of the protein-to-creatinine or albumin-to-creatinine ratio. This test should be used to detect kidney disease in people at high risk, especially those with diabetes.

If your first laboratory test shows high levels of protein, another test should be done 1 to 2 weeks later. If the second test also shows high levels of protein, you have persistent proteinuria and should have additional tests to evaluate your kidney function.

Glomerular Filtration Rate (GFR) Based on Creatinine Measurement

GFR is a calculation of how efficiently the kidneys are filtering wastes from the blood. A traditional GFR calculation requires an injection into the bloodstream of a substance that is later measured in a 24-hour urine collection. Recently, scientists found they could calculate GFR without an injection or urine collection. The new calculation requires only a measurement of the creatinine in a blood sample.

Creatinine is a waste product in the blood created by the normal breakdown of muscle cells during activity. Healthy kidneys take creatinine out of the blood and put it into the urine to leave the body. When kidneys are not working well, creatinine builds up in the blood.

In the lab, your blood will be tested to see how many milligrams of creatinine are in one deciliter of blood (mg/dL). Creatinine levels in the blood can vary, and each laboratory has its own normal range, usually 0.6 to 1. 2 mg/dL. If your creatinine level is only slightly above this range, you probably will not feel sick, but the elevation is a sign that your kidneys are not working at full strength.

One formula for estimating kidney function equates a creatinine level of 1.7 mg/dL for most men and 1.4 mg/dL for most women to 50 percent of normal kidney function. But because creatinine values are so variable and can be affected by diet, a GFR calculation is more accurate for determining whether a person has reduced kidney function.

The new GFR calculation uses the patient’s creatinine measurement along with weight, age, and values assigned for sex and race. Some medical laboratories may make the GFR calculation when a creatinine value is measured and include it on their lab report.

Blood Urea Nitrogen (BUN)

Blood carries protein to cells throughout the body. After the cells use the protein, the remaining waste product is returned to the blood as urea, a compound that contains nitrogen. Healthy kidneys take urea out of the blood and put it in the urine. If your kidneys are not working well, the urea will stay in the blood.

A deciliter of normal blood contains 7 to 20 milligrams of urea. If your BUN is more than 20 mg/dL, your kidneys may not be working at full strength. Other possible causes of an elevated BUN include dehydration and heart failure.

Additional Tests for Kidney Disease

If blood and urine tests indicate reduced kidney function, your doctor may recommend additional tests to help identify the cause of the problem:

Renal Imaging

Methods of renal imaging (taking pictures of the kidneys) include ultrasound, computed tomography (CT scan), and magnetic resonance imaging (MRI). These tools are most helpful in finding unusual growths or blockages to the flow of urine.

Renal Biopsy

Your doctor may want to see a tiny piece of your kidney tissue under a microscope. To obtain this tissue sample, the doctor will perform a renal biopsy — a hospital procedure in which the doctor inserts a needle through your skin into the back of the kidney. The needle retrieves a strand of tissue about 1/2 to 3/4 of an inch long.

For the procedure, you will lie on your stomach on a table and receive local anesthetic to numb the skin. The sample tissue will help the doctor identify problems at the cellular level.

The above information is from the National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC), a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health of the U.S. Department of Health and Human Services. Publications produced by the Clearinghouse are carefully reviewed by both NIDDK scientists and outside experts.

Creatinine Stages and Risks at Each Stage

Creatinine is a metabolic waste product produced by the metabolic activity of the body muscles. Creatinine is the determining factor to detect whether the kidneys are a function or not. The kidney functions to eliminate most of the creatinine out of the body via urine. When the kidneys are working well they efficiently excrete creatinine but high creatinine levels in the blood show chronic kidney disease (CKD).

CKD is a kidney disease that gradually shows its symptoms and is classified into 5 stages according to the severity of kidney failure (the ability to eliminate waste from the body). The kidney function is measured by Glomerular Filtration Rate (GFR). A mathematical formula involving the age, gender, race, and serum creatinine levels is used to calculate GFR. Blood tests are thus ordered to detect the stages of CKD.

Five Stages Of CKD And GFR For Each Stage

  • Stage 1 with normal or high GFR (GFR > 90 mL/min)
  • Stage 2 Mild CKD (GFR = 60-89 mL/min)
  • Stage 3A Moderate CKD (GFR = 45-59 mL/min)
  • Stage 3B Moderate CKD (GFR = 30-44 mL/min)
  • Stage 4 Severe CKD (GFR = 15-29 mL/min)
  • Stage 5 End Stage CKD (GFR

Creatinine Normal Range

The normal levels of creatinine in the blood are 0. 6 to 1.2 milligrams (mg) per deciliter (dL) in adult males and 0.5 to 1.1 mg/dL in adult females. You can find the level of creatinine in the blood high at times.

High Creatinine Levels

A very high creatinine level may require kidney transplantation or dialysis treatment.

Different symptoms of kidney dysfunction associated with high serum creatinine levels include fatigue, feeling dehydrated, edema, nausea, vomiting, confusion, dry skin, and neuropathy.

Low Creatinine Levels

Having low levels of blood creatinine levels is uncommon but it can occur due to conditions causing muscle loss. There is nothing much to worry about lower levels of blood creatinine.

Kidney health is an important factor that should be taken into consideration while performing master health checkup or opting for complete body checkup package. Serum creatinine levels play an important role in the detection of the stages of CKD. So get in touch with our Indus Health Plus experts and learn more about the health checkup packages that include creatinine tests.

Kidney health is an important factor that should be taken into consideration while performing master health checkup or opting for complete body checkup package. Serum creatinine levels play an important role in the detection of the stages of CKD. So get in touch with our Indus Health Plus experts and learn more about the health checkup packages that include creatinine tests.

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